Aliases for FDFT1 Gene
External Ids for FDFT1 Gene
Previous GeneCards Identifiers for FDFT1 Gene
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FDFT1 Gene
FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1) is a Protein Coding gene. Diseases associated with FDFT1 include keratolytic winter erythema and smith-lemli-opitz syndrome. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include oxidoreductase activity and squalene synthase activity.