Aliases for FDFT1 Gene
External Ids for FDFT1 Gene
Previous GeneCards Identifiers for FDFT1 Gene
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FDFT1 Gene
FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1) is a Protein Coding gene. Diseases associated with FDFT1 include Congenital Disorder Of Glycosylation, Type Ij and Myasthenic Syndrome, Congenital, 13, With Tubular Aggregates. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and cholesterol biosynthesis I. GO annotations related to this gene include oxidoreductase activity and farnesyl-diphosphate farnesyltransferase activity.