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Aliases for FDCSP Gene

Aliases for FDCSP Gene

  • Follicular Dendritic Cell Secreted Protein 2 3 5
  • FDC Secreted Protein 3 4
  • C4orf7 3 4
  • FDC-SP 3 4
  • Follicular Dendritic Cell Secreted Peptide 3
  • Chromosome 4 Open Reading Frame 7 2

External Ids for FDCSP Gene

Previous HGNC Symbols for FDCSP Gene

  • C4orf7

Previous GeneCards Identifiers for FDCSP Gene

  • GC04P071091

Summaries for FDCSP Gene

Entrez Gene Summary for FDCSP Gene

  • This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]

GeneCards Summary for FDCSP Gene

FDCSP (Follicular Dendritic Cell Secreted Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FDCSP Gene

  • Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDCSP Gene

Genomics for FDCSP Gene

Regulatory Elements for FDCSP Gene

Enhancers for FDCSP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F070197 0.7 ENCODE 0.3 -28.0 -28021 0.5 GATAD2A NFIA TEAD1 CEBPB TEAD3 GATA3 SSRP1 ZNF652 ZBTB26 RXRB ODAM FDCSP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FDCSP on UCSC Golden Path with GeneCards custom track

Genomic Location for FDCSP Gene

Chromosome:
4
Start:
70,226,071 bp from pter
End:
70,235,252 bp from pter
Size:
9,182 bases
Orientation:
Plus strand

Genomic View for FDCSP Gene

Genes around FDCSP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDCSP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDCSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDCSP Gene

Proteins for FDCSP Gene

  • Protein details for FDCSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU4-FDSCP_HUMAN
    Recommended name:
    Follicular dendritic cell secreted peptide
    Protein Accession:
    Q8NFU4

    Protein attributes for FDCSP Gene

    Size:
    85 amino acids
    Molecular mass:
    9700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FDCSP Gene

Post-translational modifications for FDCSP Gene

Other Protein References for FDCSP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDCSP Gene

Domains & Families for FDCSP Gene

Protein Domains for FDCSP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FDCSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FDCSP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FDCSP Gene

Function for FDCSP Gene

Molecular function for FDCSP Gene

UniProtKB/Swiss-Prot Function:
Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
genes like me logo Genes that share phenotypes with FDCSP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FDCSP Gene

Localization for FDCSP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDCSP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FDCSP gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for FDCSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FDCSP: view

Pathways & Interactions for FDCSP Gene

SuperPathways for FDCSP Gene

No Data Available

Interacting Proteins for FDCSP Gene

Gene Ontology (GO) - Biological Process for FDCSP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FDCSP Gene

Transcripts for FDCSP Gene

mRNA/cDNA for FDCSP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDCSP Gene

Follicular dendritic cell secreted protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDCSP Gene

No ASD Table

Relevant External Links for FDCSP Gene

GeneLoc Exon Structure for
FDCSP
ECgene alternative splicing isoforms for
FDCSP

Expression for FDCSP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FDCSP Gene

mRNA differential expression in normal tissues according to GTEx for FDCSP Gene

This gene is overexpressed in Minor Salivary Gland (x52.1).

Protein differential expression in normal tissues from HIPED for FDCSP Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FDCSP Gene



Protein tissue co-expression partners for FDCSP Gene

NURSA nuclear receptor signaling pathways regulating expression of FDCSP Gene:

FDCSP

SOURCE GeneReport for Unigene cluster for FDCSP Gene:

Hs.733448

mRNA Expression by UniProt/SwissProt for FDCSP Gene:

Q8NFU4-FDSCP_HUMAN
Tissue specificity: Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.
genes like me logo Genes that share expression patterns with FDCSP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FDCSP Gene

Orthologs for FDCSP Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FDCSP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDCSP 34 35
  • 99.22 (n)
Species where no ortholog for FDCSP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FDCSP Gene

ENSEMBL:
Gene Tree for FDCSP (if available)
TreeFam:
Gene Tree for FDCSP (if available)

Paralogs for FDCSP Gene

(1) SIMAP similar genes for FDCSP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FDCSP: view

No data available for Paralogs for FDCSP Gene

Variants for FDCSP Gene

Sequence variations from dbSNP and Humsavar for FDCSP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10518072 -- 70,224,941(-) TCTCA(A/G)TGATT upstream-variant-2KB
rs10636672 -- 70,224,781(+) ATAAT(-/AC)ACACA upstream-variant-2KB
rs111261489 -- 70,233,681(+) TTTCC(A/T)ACATG intron-variant
rs111262325 -- 70,232,824(+) TACAT(A/G)TTAAG intron-variant
rs111364664 -- 70,233,659(+) AGATA(A/C)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FDCSP Gene

Variant ID Type Subtype PubMed ID
dgv5319n100 CNV loss 25217958
esv3303928 CNV mobile element insertion 20981092
esv3338971 CNV insertion 20981092
esv3386135 CNV insertion 20981092
nsv1012495 CNV gain 25217958
nsv829963 CNV gain 17160897
nsv998828 CNV gain 25217958

Variation tolerance for FDCSP Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FDCSP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FDCSP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDCSP Gene

Disorders for FDCSP Gene

Relevant External Links for FDCSP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FDCSP

No disorders were found for FDCSP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDCSP Gene

Publications for FDCSP Gene

  1. FDC-SP, a novel secreted protein expressed by follicular dendritic cells. (PMID: 12193705) Marshall A.J. … Clark E.A. (J. Immunol. 2002) 2 3 4 22 64
  2. C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion. (PMID: 20811673) Wang C. … Ma D. (Oncol. Rep. 2010) 2 3 64
  3. Follicular dendritic cell secreted protein (FDC-SP) regulates germinal center and antibody responses. (PMID: 17548624) Al-Alwan M. … Marshall A.J. (J. Immunol. 2007) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for FDCSP Gene

Sources for FDCSP Gene

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