Aliases for FDCSP Gene
Aliases for FDCSP Gene
External Ids for FDCSP Gene
- HGNC: 19215
- Entrez Gene: 260436
- Ensembl: ENSG00000181617
- OMIM: 607241
- UniProtKB: Q8NFU4
Previous HGNC Symbols for FDCSP Gene
- C4orf7
Previous GeneCards Identifiers for FDCSP Gene
- GC04P071091
Summaries for FDCSP Gene
-
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
GeneCards Summary for FDCSP Gene
FDCSP (Follicular Dendritic Cell Secreted Protein) is a Protein Coding gene.
UniProtKB/Swiss-Prot for FDCSP Gene
-
Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDCSP Gene
Genomics for FDCSP Gene
Regulatory Elements for FDCSP Gene
Enhancers for FDCSP Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G070197 | 0.7 | ENCODE | 0.3 | -28.0 | -28021 | 0.5 | GATAD2A NFIB TEAD1 NFIA CEBPB TEAD3 SSRP1 GATA3 ZNF652 ZBTB26 | ODAM FDCSP |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FDCSP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FDCSP Gene
- Chromosome:
- 4
- Start:
- 70,226,071 bp from pter
- End:
- 70,235,252 bp from pter
- Size:
- 9,182 bases
- Orientation:
- Plus strand
Genomic View for FDCSP Gene
Genes around FDCSP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13.3|4q13 by Entrez Gene
- 4q13.3 by HGNC
FDCSP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FDCSP Gene
Proteins for FDCSP Gene
-
Protein details for FDCSP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NFU4-FDSCP_HUMAN
- Recommended name:
- Follicular dendritic cell secreted peptide
- Protein Accession:
- Q8NFU4
Protein attributes for FDCSP Gene
- Size:
- 85 amino acids
- Molecular mass:
- 9700 Da
- Quaternary structure:
- No Data Available
Protein Expression for FDCSP Gene
Post-translational modifications for FDCSP Gene
- O-glycosylated with core 1 or possibly core 8 glycans.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FDCSP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FDCSP
- Invitrogen Antibodies for FDCSP
- antibodies-online Antibodies for FDCSP: See all 16
- Search GeneTex for Antibodies for FDCSP
Protein Products
-
OriGene Purified Proteins for FDCSP
- Search Origene for MassSpec and Protein Over-expression Lysates for FDCSP
- Origene Custom Protein Services for FDCSP
- ProSpec Recombinant Proteins for FDCSP
- antibodies-online Proteins for FDCSP: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FDCSP
Assay Products
No data available for DME Specific Peptides for FDCSP Gene
Domains & Families for FDCSP Gene
Suggested Antigen Peptide Sequences for FDCSP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for FDCSP Gene
Function for FDCSP Gene
Molecular function for FDCSP Gene
- UniProtKB/Swiss-Prot Function:
- Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
Phenotypes for FDCSP Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FDCSP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FDCSP gene
- Search ViGene Biosciences for FDCSP
CRISPR Products
-
OriGene CRISPR knockouts for FDCSP
-
Santa Cruz Biotechnology (SCBT) CRISPR for FDCSP
- GenScript: Design CRISPR guide RNA sequences for FDCSP
miRNA Products
- Search ViGene Biosciences for FDCSP
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FDCSP
- Browse OriGene Inhibitory RNA Products For FDCSP
-
ViGene Biosciences ready-to-package AAV shRNAs for FDCSP gene
Clone Products
-
OriGene ORF clones in human for FDCSP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FDCSP
-
ViGene Biosciences adenoviral particle packaged cDNA for FDCSP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FDCSP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FDCSP gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FDCSP Gene
Localization for FDCSP Gene
Subcellular locations from UniProtKB/Swiss-Prot for FDCSP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
Transcripts for FDCSP Gene
mRNA/cDNA for FDCSP Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (59) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FDCSP Gene
CRISPR Products
-
OriGene CRISPR knockouts for FDCSP
-
Santa Cruz Biotechnology (SCBT) CRISPR for FDCSP
- GenScript: Design CRISPR guide RNA sequences for FDCSP
miRNA Products
- Search ViGene Biosciences for FDCSP
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FDCSP
- Browse OriGene Inhibitory RNA Products For FDCSP
-
ViGene Biosciences ready-to-package AAV shRNAs for FDCSP gene
Clone Products
-
OriGene ORF clones in human for FDCSP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FDCSP Gene
mRNA differential expression in normal tissues according to GTEx for FDCSP Gene
This gene is overexpressed in Minor Salivary Gland (x52.1).
This gene is overexpressed in Salivary gland (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FDCSP Gene
NURSA nuclear receptor signaling pathways regulating expression of FDCSP Gene:
FDCSPSOURCE GeneReport for Unigene cluster for FDCSP Gene:
Hs.733448mRNA Expression by UniProt/SwissProt for FDCSP Gene:
Q8NFU4-FDSCP_HUMAN
Tissue specificity:
Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.
Evidence on tissue expression from TISSUES for FDCSP Gene
- Thyroid gland(4)
- Lymph node(3)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for FDCSP
-
OriGene qPCR primer pairs and template standards for FDCSP
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FDCSP Gene
Orthologs for FDCSP Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FDCSP 34 35 |
|
- Species where no ortholog for FDCSP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FDCSP Gene
(1) SIMAP similar genes for FDCSP Gene using alignment to 1 proteins:
No data available for Paralogs for FDCSP Gene
Variants for FDCSP Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000097984 | -- | 70,226,551(+) | GCCCC(A/G)CCAGA | intron-variant | |
| rs1000211549 | -- | 70,231,235(+) | GGCAG(C/T)GGCTG | reference, missense | |
| rs1000474341 | -- | 70,229,383(+) | TCTTT(C/T)GCTTT | intron-variant | |
| rs1000547534 | -- | 70,229,687(+) | GGGCA(C/T)GGCCA | intron-variant | |
| rs1000574027 | -- | 70,232,834(+) | GACTT(C/T)TTGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5319n100 | CNV | loss | 25217958 |
| esv3303928 | CNV | mobile element insertion | 20981092 |
| esv3338971 | CNV | insertion | 20981092 |
| esv3386135 | CNV | insertion | 20981092 |
| nsv1012495 | CNV | gain | 25217958 |
| nsv829963 | CNV | gain | 17160897 |
| nsv998828 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.91% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FDCSP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FDCSP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDCSP Gene
Disorders for FDCSP Gene
Relevant External Links for FDCSP
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FDCSP
No disorders were found for FDCSP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDCSP Gene
Publications for FDCSP Gene
- FDC-SP, a novel secreted protein expressed by follicular dendritic cells. (PMID: 12193705) Marshall A.J. … Clark E.A. (J. Immunol. 2002) 2 3 4 22 64
- C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion. (PMID: 20811673) Wang C. … Ma D. (Oncol. Rep. 2010) 2 3 64
- Follicular dendritic cell secreted protein (FDC-SP) regulates germinal center and antibody responses. (PMID: 17548624) Al-Alwan M. … Marshall A.J. (J. Immunol. 2007) 2 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
Products for FDCSP Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FDCSP
- Search Origene for MassSpec and Protein Over-expression Lysates for FDCSP
- Origene Custom Protein Services for FDCSP
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FDCSP
- Browse OriGene Inhibitory RNA Products For FDCSP
- OriGene qPCR primer pairs and template standards for FDCSP
- OriGene qPCR primer pairs for FDCSP
- OriGene CRISPR knockouts for FDCSP
- OriGene ORF clones in human for FDCSP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FDCSP
- GenScript: Next-day shipping cDNA ORF clone for FDCSP in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FDCSP
- GenScript Custom Assay Services for FDCSP
- GenScript Custom overexpressing Cell Line Services for FDCSP
- GenScript: Design CRISPR guide RNA sequences for FDCSP
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- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FDCSP
- Novus Biologicals proteins and lysates for FDCSP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for FDCSP
- antibodies-online Antibodies for FDCSP: See all 16
- Search antibodies-online for kits
- antibodies-online Proteins for FDCSP: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for FDCSP
- Search GeneTex for Proteins for FDCSP
- ViGene Biosciences adenoviral particle packaged cDNA for FDCSP gene
- ViGene Biosciences lentiviral particle packaged cDNA for FDCSP gene
- ViGene Biosciences ready-to-package AAV shRNAs for FDCSP gene
- Search ViGene Biosciences for FDCSP
- Horizon Cell Lines for FDCSP
- Cyagen custom Knockout/knockin (KOKI) mouse models for FDCSP
- VectorBuilder custom plasmid, inducible vectors for FDCSP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FDCSP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FDCSP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer