FDCSP Gene
protein-coding GIFtS: 38
GCID: GC04P071091
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follicular dendritic cell secreted protein(Previous name: chromosome 4 open reading frame 7 )
(Previous symbol: C4orf7)
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Aliases
for FDCSP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Follicular Dendritic Cell Secreted Protein1 2 | | C4orf71 2 3 | | FDC-SP1 2 3 | | FDC Secreted Protein2 3 | | Chromosome 4 Open Reading Frame 71 | | Follicular Dendritic Cell Secreted Peptide2 |
Export aliases for FDCSP gene to outside databases |
Summaries
for FDCSP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FDCSP:
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specificallybinds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute totumor metastases by promoting cancer cell migration and invasion. (provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: FDSCP_HUMAN, Q8NFU4Function: Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as asecreted mediator acting upon B-cells
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Genomic Views
for FDCSP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FDCSP
Other transcription factors
Search SABiosciences Chromatin IP Primers for FDCSP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDCSP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13|4q13 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13FDCSP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P071091: view genomic region
(about GC identifiers)
Start:
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71,091,788 bp from pter |
End:
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71,100,969 bp from pter |
Size:
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9,182 bases |
Orientation:
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plus strand |
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Proteins
for FDCSP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FDSCP_HUMAN, Q8NFU4 (See
protein sequence)Recommended Name: Follicular dendritic cell secreted peptide precursor Size: 85 amino acids; 9700 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for FDCSP: NX_Q8NFU4
Post-translational modifications:
O-glycosylated with core 1 or possibly core 8 glycans1
View neXtProt modification sites for NX_Q8NFU4
FDCSP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694542.1
ENSEMBL proteins: ENSP00000318437
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
FDCSP for ontologies About GeneDecksing
FDCSP Antibody Products:
Assay Products for FDCSP: |
Protein
Domains /
Families
for FDCSP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NFU4 |
Function
for FDCSP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FDSCP_HUMAN, Q8NFU4Function: Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as asecreted mediator acting upon B-cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDCSP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDCSP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for FDCSP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDCSP |
1 GenomeRNAi human phenotype for FDCSP:
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Pathways & Interactions
for FDCSP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FDCSP
|
Drugs & Compounds
for FDCSP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FDCSP
Search CenterWatch for drugs/clinical trials and news about FDCSP / FDSCP
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Transcripts
for FDCSP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FDCSP gene: NM_152997.3 Unigene Cluster for FDCSP: Follicular dendritic cell secreted protein Hs.733448 [show with all ESTs]Unigene Representative Sequence: CB9580281 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000317987(uc003hfd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDCSP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDCSP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FDCSP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FDCSP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDCSP |
Additional cDNA sequence: AF086120.1 AF435080.1 AY190326.1 AY358958.1 BC062213.1 2 DOTS entries: DT.92423340 DT.95180700 24/59 AceView cDNA sequences (see all 59): NM_152997 AY190326 AI862746 BG271408 AA507382 BG059093 AW276439 AW268642 AI391465 CB123365 CB130829 AA614722 BE041192 AI708198 AA719940 AF435080 AF086120 AI718421 AI719838 AI253742 BC062213 CB956150 AI510752 AW269501
GeneLoc Exon Structure
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Expression
for FDCSP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FDCSP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCAAAAA
About this image
See FDCSP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FDCSP
SOURCE GeneReport for Unigene cluster: Hs.733448
UniProtKB/Swiss-Prot: FDSCP_HUMAN, Q8NFU4Tissue specificity: Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lowerexpression in thyroid, stomach, and colon
SABiosciences Custom PCR Arrays for FDCSP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FDCSP
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FDCSP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDCSP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDCSP |
Orthologs
for FDCSP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for FDCSP (if available)
TreeFam Gene Tree for FDCSP (if available) |
Paralogs
for FDCSP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FDCSP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FDCSP |
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Disorders
/ Diseases
for FDCSP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FDCSP for disorders About GeneDecksing
OMIM gene information: 607241
OMIM disorders: --
5  diseases for FDCSP: About MalaCardstonsillitis periodontitis ovarian cancer thyroiditis
prostatitis
Export disorders for FDCSP gene to outside databases
|
Publications
for FDCSP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FDCSP gene integrated from 9 sources:
(articles sorted by number of sources associating them with FDCSP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FDC-SP, a novel secreted protein expressed by follicular dendritic cells. (PubMed id 12193705)1, 2, 3, 9 Marshall A.J....Clark E.A. (2002)
- C4orf7 contributes to ovarian cancer metastasis by pr omoting cancer cell migration and invasion. (PubMed id 20811673)1, 3 Wang C....Ma D. (2010)
- Follicular dendritic cell secreted protein (FDC-SP) regulates germinal center and antibody responses. (PubMed id 17548624)1, 3 Al-Alwan M....Marshall A.J. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of genes preferentially expressed in periodontal ligament: specific expression of a novel secreted protein, FDC-SP. (PubMed id 16259954)1 Nakamura S....Shinomura T. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FDCSP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FDCSP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FDCSP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FDCSP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FDCSP | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FDCSP gene:
Search GeneIP for patents involving FDCSP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FDCSP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FDCSP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FDCSP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FDCSP | | | OriGene Protein Over-expression Lysate for FDCSP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FDCSP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FDCSP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FDCSP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FDCSP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FDCSP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FDCSP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FDCSP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FDCSP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FDCSP |
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 | | | FDCSP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FDCSP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FDCSP |
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