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Aliases for FDCSP Gene

Aliases for FDCSP Gene

  • Follicular Dendritic Cell Secreted Protein 2 3
  • FDC Secreted Protein 3 4
  • C4orf7 3 4
  • FDC-SP 3 4
  • Follicular Dendritic Cell Secreted Peptide 3
  • Chromosome 4 Open Reading Frame 7 2

External Ids for FDCSP Gene

Previous HGNC Symbols for FDCSP Gene

  • C4orf7

Previous GeneCards Identifiers for FDCSP Gene

  • GC04P071091

Summaries for FDCSP Gene

Entrez Gene Summary for FDCSP Gene

  • This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]

GeneCards Summary for FDCSP Gene

FDCSP (Follicular Dendritic Cell Secreted Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FDCSP Gene

  • Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDCSP Gene

Genomics for FDCSP Gene

Genomic Location for FDCSP Gene

Start:
70,226,071 bp from pter
End:
70,235,252 bp from pter
Size:
9,182 bases
Orientation:
Plus strand

Genomic View for FDCSP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FDCSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDCSP Gene

No data available for Regulatory Elements for FDCSP Gene

Proteins for FDCSP Gene

  • Protein details for FDCSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU4-FDSCP_HUMAN
    Recommended name:
    Follicular dendritic cell secreted peptide
    Protein Accession:
    Q8NFU4
    Secondary Accessions:

    Protein attributes for FDCSP Gene

    Size:
    85 amino acids
    Molecular mass:
    9700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FDCSP Gene

Proteomics data for FDCSP Gene at MOPED

Post-translational modifications for FDCSP Gene

Other Protein References for FDCSP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDCSP Gene

Domains for FDCSP Gene

Protein Domains for FDCSP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FDCSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FDCSP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FDCSP Gene

Function for FDCSP Gene

Molecular function for FDCSP Gene

UniProtKB/Swiss-Prot Function: Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells

Phenotypes for FDCSP Gene

genes like me logo Genes that share phenotypes with FDCSP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDCSP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FDCSP Gene

Localization for FDCSP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDCSP Gene

Secreted.

Gene Ontology (GO) - Cellular Components for FDCSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FDCSP: view

No data available for Subcellular locations from COMPARTMENTS for FDCSP Gene

Pathways for FDCSP Gene

SuperPathways for FDCSP Gene

No Data Available

Interacting Proteins for FDCSP Gene

Gene Ontology (GO) - Biological Process for FDCSP Gene

None

No data available for Pathways by source for FDCSP Gene

Transcripts for FDCSP Gene

mRNA/cDNA for FDCSP Gene

(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDCSP Gene

Follicular dendritic cell secreted protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDCSP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDCSP Gene

No ASD Table

Relevant External Links for FDCSP Gene

GeneLoc Exon Structure for
FDCSP
ECgene alternative splicing isoforms for
FDCSP

Expression for FDCSP Gene

mRNA expression in normal human tissues for FDCSP Gene

mRNA differential expression in normal tissues according to GTEx for FDCSP Gene

This gene is overexpressed in Minor Salivary Gland (52.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FDCSP Gene

SOURCE GeneReport for Unigene cluster for FDCSP Gene Hs.733448

mRNA Expression by UniProt/SwissProt for FDCSP Gene

Q8NFU4-FDSCP_HUMAN
Tissue specificity: Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.
genes like me logo Genes that share expressions with FDCSP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FDCSP Gene

Orthologs for FDCSP Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FDCSP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDCSP 35
  • 99.22 (n)
  • 98.82 (a)
FDCSP 36
  • 99 (a)
OneToOne
Species with no ortholog for FDCSP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FDCSP Gene

ENSEMBL:
Gene Tree for FDCSP (if available)
TreeFam:
Gene Tree for FDCSP (if available)

Paralogs for FDCSP Gene

Selected SIMAP similar genes for FDCSP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FDCSP: view

No data available for Paralogs for FDCSP Gene

Variants for FDCSP Gene

Sequence variations from dbSNP and Humsavar for FDCSP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs777793 -- 70,235,216(+) TAAAC(A/T)TGAAA utr-variant-3-prime
rs777796 -- 70,229,616(-) tgggc(C/T)agtta intron-variant
rs777797 -- 70,227,456(-) CTATA(C/T)ATCTA intron-variant
rs810359 -- 70,227,816(-) ctgct(A/G)ttaca intron-variant
rs986497 -- 70,226,039(-) CTAGG(A/T)TCAGT upstream-variant-2KB

Relevant External Links for FDCSP Gene

HapMap Linkage Disequilibrium report
FDCSP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FDCSP Gene

Disorders for FDCSP Gene

No disorders were found for FDCSP Gene.

No data available for UniProtKB/Swiss-Prot for FDCSP Gene

Publications for FDCSP Gene

  1. FDC-SP, a novel secreted protein expressed by follicular dendritic cells. (PMID: 12193705) Marshall A.J. … Clark E.A. (J. Immunol. 2002) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Follicular dendritic cell secreted protein (FDC-SP) regulates germinal center and antibody responses. (PMID: 17548624) Al-Alwan M. … Marshall A.J. (J. Immunol. 2007) 2 3
  5. C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion. (PMID: 20811673) Wang C. … Ma D. (Oncol. Rep. 2010) 2 3

Products for FDCSP Gene

Sources for FDCSP Gene

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