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Aliases for FCRLB Gene

Aliases for FCRLB Gene

  • Fc Receptor-Like B 2 3
  • Fc Receptor-Like And Mucin-Like Protein 2 3 4
  • Fc Receptor-Related Protein Y 3 4
  • Fc Receptor-Like Protein 2 3 4
  • FCRLM2 3 4
  • FREB-2 3 4
  • FCRL2 3 4
  • FcRY 3 4
  • Fc Receptor Homolog Expressed In B Cells Protein 2 3
  • Fc Receptor Homolog Expressed In B-Cells Protein 2 4
  • Fc Receptor-Like And Mucin-Like 2 2
  • FCRLY 3
  • FREB2 4

External Ids for FCRLB Gene

Previous HGNC Symbols for FCRLB Gene

  • FCRLM2

Previous GeneCards Identifiers for FCRLB Gene

  • GC01P159958
  • GC01P161691
  • GC01P132936

Summaries for FCRLB Gene

Entrez Gene Summary for FCRLB Gene

  • FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FCRLB Gene

FCRLB (Fc Receptor-Like B) is a Protein Coding gene. An important paralog of this gene is FCRL2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRLB Gene

Genomics for FCRLB Gene

Regulatory Elements for FCRLB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FCRLB Gene

Start:
161,721,544 bp from pter
End:
161,728,143 bp from pter
Size:
6,600 bases
Orientation:
Plus strand

Genomic View for FCRLB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCRLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRLB Gene

Proteins for FCRLB Gene

  • Protein details for FCRLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6BAA4-FCRLB_HUMAN
    Recommended name:
    Fc receptor-like B
    Protein Accession:
    Q6BAA4
    Secondary Accessions:
    • A2A3J5
    • A2A3J7
    • Q5VXA6
    • Q6BAA0
    • Q6BAA1
    • Q6BAA2
    • Q6BAA3
    • Q8IXZ7

    Protein attributes for FCRLB Gene

    Size:
    426 amino acids
    Molecular mass:
    46904 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCRLB Gene

Proteomics data for FCRLB Gene at MOPED

Post-translational modifications for FCRLB Gene

  • Glycosylation at Asn152
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FCRLB Gene

Domains for FCRLB Gene

Gene Families for FCRLB Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCRLB Gene

Suggested Antigen Peptide Sequences for FCRLB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6BAA4

UniProtKB/Swiss-Prot:

FCRLB_HUMAN :
  • Q6BAA4
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCRLB: view

Function for FCRLB Gene

Gene Ontology (GO) - Molecular Function for FCRLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FCRLB: view

Phenotypes for FCRLB Gene

genes like me logo Genes that share phenotypes with FCRLB: view

Animal Models for FCRLB Gene

MGI Knock Outs for FCRLB:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FCRLB Gene

Localization for FCRLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRLB Gene

Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCRLB Gene COMPARTMENTS Subcellular localization image for FCRLB gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
extracellular 3
plasma membrane 3
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FCRLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15815692
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with FCRLB: view

Pathways for FCRLB Gene

SuperPathways for FCRLB Gene

No Data Available

Interacting Proteins for FCRLB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356925%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000356925 for FCRLB Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for FCRLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050777 negative regulation of immune response IEA --
genes like me logo Genes that share ontologies with FCRLB: view

No data available for Pathways by source for FCRLB Gene

Transcripts for FCRLB Gene

Unigene Clusters for FCRLB Gene

Fc receptor-like B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCRLB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRLB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for FCRLB Gene

GeneLoc Exon Structure for
FCRLB
ECgene alternative splicing isoforms for
FCRLB

Expression for FCRLB Gene

mRNA expression in normal human tissues for FCRLB Gene

Protein differential expression in normal tissues for FCRLB Gene

This gene is overexpressed in Heart (34.5) and Peripheral blood mononuclear cells (34.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCRLB Gene

SOURCE GeneReport for Unigene cluster for FCRLB Gene Hs.517422

mRNA Expression by UniProt/SwissProt for FCRLB Gene

Q6BAA4-FCRLB_HUMAN
Tissue specificity: Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein level).
genes like me logo Genes that share expressions with FCRLB: view

Expression partners for FCRLB Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FCRLB Gene

Orthologs for FCRLB Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCRLB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCRLB 35
  • 86.33 (n)
  • 88.49 (a)
FCRLB 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCRLB 35
  • 86.67 (n)
  • 84.17 (a)
FCRLB 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcrlb 35
  • 83.45 (n)
  • 83.61 (a)
Fcrlb 16
Fcrlb 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FCRLB 35
  • 99.61 (n)
  • 99.53 (a)
FCRLB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcrlb 35
  • 83.77 (n)
  • 86.22 (a)
oppossum
(Monodelphis domestica)
Mammalia FCRLB 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FCRLB 36
  • 52 (a)
OneToOne
Species with no ortholog for FCRLB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRLB Gene

ENSEMBL:
Gene Tree for FCRLB (if available)
TreeFam:
Gene Tree for FCRLB (if available)

Paralogs for FCRLB Gene

Selected SIMAP similar genes for FCRLB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FCRLB: view

Variants for FCRLB Gene

Sequence variations from dbSNP and Humsavar for FCRLB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs905591 -- 161,722,137(-) ATCCT(C/G)CCACA intron-variant, upstream-variant-2KB
rs905592 -- 161,722,132(-) GCCAC(A/G)ATGAG intron-variant, upstream-variant-2KB
rs1417582 -- 161,726,298(+) GCACA(C/T)CCTGG intron-variant
rs1847382 -- 161,725,591(-) AAACT(C/G)GGTTC intron-variant
rs1875763 -- 161,727,208(+) AGAAC(C/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRLB Gene

Variant ID Type Subtype PubMed ID
nsv428257 CNV Loss 18775914
esv33393 CNV Gain+Loss 17666407
nsv464184 CNV Gain 19166990
nsv516773 CNV Gain 19592680
esv2718895 CNV Deletion 23290073
nsv464195 CNV Loss 19166990

Relevant External Links for FCRLB Gene

HapMap Linkage Disequilibrium report
FCRLB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRLB Gene

Disorders for FCRLB Gene

Relevant External Links for FCRLB

Genetic Association Database (GAD)
FCRLB
Human Genome Epidemiology (HuGE) Navigator
FCRLB

No disorders were found for FCRLB Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FCRLB Gene

Publications for FCRLB Gene

  1. Cloning and characterization of the human FCRL2 gene. (PMID: 15676285) Chikaev N.A. … Taranin A.V. (Genomics 2005) 2 3 4 23
  2. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. (PMID: 16263223) Masuda K. … Burrows P.D. (Gene 2005) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A new Fc receptor homolog, FREB2, found in germinal center B cells. (PMID: 15815692) Wilson T.J. … Colonna M. (Genes Immun. 2005) 3 4
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48

Products for FCRLB Gene

Sources for FCRLB Gene

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