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FCRLB Gene

protein-coding   GIFtS: 46
GCID: GC01P161691

Fc Receptor-Like B

(Previous name: Fc receptor-like and mucin-like 2)
(Previous symbol: FCRLM2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Receptor-Like B1 2     FcRY2 3
FCRLM21 2 3     Fc Receptor-Like And Mucin-Like 21
Fc Receptor-Like And Mucin-Like Protein 22 3     FCRLY2
Fc Receptor-Like Protein 22 3     Fc Receptor Homolog Expressed In B Cells Protein 22
Fc Receptor-Related Protein Y2 3     FCRY3
FCRL22 3     FREB23
FREB-22 3     Fc Receptor Homolog Expressed In B-Cells Protein 23

External Ids:    HGNC: 264311   Entrez Gene: 1279432   Ensembl: ENSG000001627467   OMIM: 6092515   UniProtKB: Q6BAA43   

Export aliases for FCRLB gene to outside databases

Previous GC identifers: GC01P159958 GC01P132936


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCRLB Gene:
FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell
cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind
immunoglobulin (Ig) constant regions (Chikaev et al., 2005 (PubMed 15676285)).(supplied by OMIM, Mar 2008)

GeneCards Summary for FCRLB Gene:
FCRLB (Fc receptor-like B) is a protein-coding gene. An important paralog of this gene is FCGR1B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCRLB gene promoter:
         AhR   STAT5B   POU3F1   MyoD   STAT5A   Nkx2-5   LCR-F1   Arnt   FOXL1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCRLB promoter sequence
   Search Chromatin IP Primers for FCRLB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCRLB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

FCRLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCRLB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161691:  view genomic region     (about GC identifiers)

Start:
161,691,353 bp from pter      End:
161,697,933 bp from pter
Size:
6,581 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCRLB_HUMAN, Q6BAA4 (See protein sequence)
Recommended Name: Fc receptor-like B precursor  
Size: 426 amino acids; 46904 Da
Secondary accessions: A2A3J5 A2A3J7 Q5VXA6 Q6BAA0 Q6BAA1 Q6BAA2 Q6BAA3 Q8IXZ7
Alternative splicing: 5 isoforms:  Q6BAA4-1   Q6BAA4-2   Q6BAA4-3   Q6BAA4-4   Q6BAA4-5   

Explore the universe of human proteins at neXtProt for FCRLB: NX_Q6BAA4

Explore proteomics data for FCRLB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn152

  • See FCRLB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001002901.1  NP_001275758.1  NP_001275759.1  NP_001275760.1  NP_001275761.1  

    ENSEMBL proteins: 
     ENSP00000356925   ENSP00000356923   ENSP00000356922   ENSP00000338598   ENSP00000356921  
     ENSP00000375999  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q6BAA4

    ProtoNet protein and cluster: Q6BAA4

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: FCRLB_HUMAN, Q6BAA4
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCRLB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FCRLB           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fcrlb):
     hematopoietic system  immune system 

    Find genes that share phenotypes with FCRLB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fcrlbtm1Pdb for FCRLB

       genOway: Develop your customized and physiologically relevant rodent model for FCRLB

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    SwitchGear 3'UTR luciferase reporter plasmidFCRLB 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCRLB_HUMAN, Q6BAA4: Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol3
    extracellular3
    plasma membrane3
    endosome1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15815692
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with FCRLB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCRLB
    Interactions:

        Search GeneGlobe Interaction Network for FCRLB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FCRLB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCRLB gene (5 alternative transcripts): 
    NM_001002901.3  NM_001288829.1  NM_001288830.1  NM_001288831.1  NM_001288832.1  

    Unigene Cluster for FCRLB:

    Fc receptor-like B
    Hs.517422  [show with all ESTs]
    Unigene Representative Sequence: BC067080
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367948(uc001gbh.3 uc009wus.3 uc001gbi.3 uc001gbj.3 uc001gbk.3 uc001gbl.3 uc001gbm.3)
    ENST00000367946 ENST00000367945 ENST00000336830 ENST00000367944 ENST00000495397(uc001gbn.4)
    ENST00000392158
    miRNA
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    hsa-miR-138-1* hsa-miR-140-3p hsa-miR-548d-3p hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidFCRLB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK055614.1 AK290733.1 AY670683.1 AY670684.1 AY670685.1 AY670686.1 AY670687.1 AY786314.1 
    BC038564.2 BC067080.1 DQ021957.1 

    5 DOTS entries:

    DT.201600  DT.100811443  DT.121389680  DT.121389683  DT.100673387 

    Selected AceView cDNA sequences (see all 36):

    AY670686 BQ014028 NM_001002901 AY670684 AI817123 BC038564 BQ014014 AA746047 
    BX280522 AY670683 BI092705 BE895345 AA693721 BE965639 AY670687 BX443921 
    BQ232294 AY670685 AI393356 BC067080 AK055614 NM_152378 CA442500 AL519963 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FCRLB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:                                                      
    SP2:                                                      
    SP3:                                -                     
    SP4:                                -     -               


    ECgene alternative splicing isoforms for FCRLB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCRLB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCGCAGCC
    FCRLB Expression
    About this image

    FCRLB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCRLB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517422

    UniProtKB/Swiss-Prot: FCRLB_HUMAN, Q6BAA4
    Tissue specificity: Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen
    and placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein
    level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCRLB gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcrlb1 , 5 Fc receptor-like B1, 5 83.45(n)1
    83.61(a)1
      1 (77.56 cM)5
    4356531  NM_001029984.21  NP_001025155.21 
     1709072735 


    ENSEMBL Gene Tree for FCRLB (if available)
    TreeFam Gene Tree for FCRLB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCRLB gene
    FCGR1B2  FCGR2B2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  FCRL42  
    FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    11 SIMAP similar genes for FCRLB using alignment to 1 protein entry:     FCRLB_HUMAN:
    DKFZp686L20250    FCER1A    FCGR1B    FCGR2A    FCRL3    FCRL5
    FCGR1A    FCRLA    FCGR2B    FCGR3B    Fc-gamma receptor IIIB

    Find genes that share paralogs with FCRLB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCRLB (see all 207)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356956991,2
    C--132942561(+) GGGGG-/G/GGGG
            
    AATCA
    1 -- int11NA 2
    rs716349071,2
    C,F--161690593(+) TTTTTC/ATGCAT 1 -- us2k13Minor allele frequency- A:0.05NA 124
    rs1389521831,2
    --161690639(+) AGTCCC/TAGATG 1 -- us2k10--------
    rs1153898141,2
    F--161690704(+) TATTTC/TGTGGG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1492784671,2
    --161690705(+) ATTTCA/GTGGGA 1 -- us2k10--------
    rs1143208331,2
    F--161690764(+) TGGTTC/TCAGAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs64276221,2
    C,F,H--161690781(+) AGGGAA/CGACTA 1 -- us2k119Minor allele frequency- C:0.15NA NS EA WA CSA 927
    rs1896720171,2
    --161690829(+) TGAATC/TGAGTA 1 -- us2k10--------
    rs1444803851,2
    --161690932(+) TTACCA/GTTGAG 1 -- us2k10--------
    rs1484072821,2
    --161691091(+) ATCATC/TCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCRLB (161691353 - 161697933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FCRLB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718895CNV Deletion23290073
    nsv464195CNV Loss19166990
    nsv428257CNV Loss18775914
    nsv516773CNV Gain19592680
    nsv464184CNV Gain19166990
    esv33393CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609251    OMIM disorders: --


    Find genes that share disorders with FCRLB           About GenesLikeMe

    Genetic Association Database (GAD): FCRLB
    Human Genome Epidemiology (HuGE) Navigator: FCRLB (3 documents)

    Export disorders for FCRLB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCRLB gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with FCRLB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human FCRL2 gene. (PubMed id 15676285)1, 2, 3, 9 Chikaev N.A.... Taranin A.V. (Genomics 2005)
    2. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. (PubMed id 16263223)1, 2, 9 Masuda K.... Burrows P.D. (Gene 2005)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    5. A new Fc receptor homolog, FREB2, found in germinal center B cells. (PubMed id 15815692)1, 2 Wilson T.J. and Colonna M. (Genes Immun. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy. (PubMed id 23593433)1 Zhou X.J....Zhang H. (PLoS ONE 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. (PubMed id 17273841)1 Taylor A.I....Calvert R.A. (Immunogenetics 2007)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127943 HGNC: 26431 AceView: FLJ31052 Ensembl:ENSG00000162746 euGenes: HUgn127943
    ECgene: FCRLB H-InvDB: FCRLB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FCRLB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCRLB gene:
    Search GeneIP for patents involving FCRLB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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