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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FCRLB Gene

protein-coding GIFtS: 47
GCID: GC01P161691

Fc receptor-like B

(Previous name: Fc receptor-like and mucin-like 2 )
(Previous symbol: FCRLM2)

Explore 2 diseases affiliated with
FCRLB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fc Receptor-Like B¹ ²		Fc Receptor-Related Protein Y² ³
FCRL2¹ ² ³		FcRY² ³
FCRLM2¹ ² ³		Fc Receptor Homolog Expressed In B-Cells Protein 2² ³
FREB-2¹ ² ³		FLJ31052¹
FCRLY¹ ²		Fc Receptor Homolog Expressed In B Cells Protein 2²
Fc Receptor-Like And Mucin-Like 2¹ ²		Fc Receptor Like 2²
Fc Receptor-Like And Mucin-Like Protein 2² ³		FCRY³
Fc Receptor-Like Protein 2² ³		FREB2³

External Ids:	HGNC: 26431¹	Entrez Gene: 127943²	Ensembl: ENSG00000162746⁷	OMIM: 609251⁵	UniProtKB: Q6BAA4³

Export aliases for FCRLB gene to outside databases

Previous GC identifers: GC01P159958 GC01P132936

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCRLB:

FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell

cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin

(Ig) constant regions (Chikaev et al., 2005 (PubMed 15676285)).(supplied by OMIM, Mar 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FCRLB gene promoter:
AhR STAT5B POU3F1 MyoD STAT5A Nkx2-5 LCR-F1 Arnt FOXL1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCRLB promoter sequence

Search SABiosciences Chromatin IP Primers for FCRLB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRLB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3

FCRLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCRLB gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P161691: view genomic region (about GC identifiers)

Start:	161,691,353 bp from pter	End:	161,697,933 bp from pter
Size:	6,581 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCRLB_HUMAN, Q6BAA4 (See protein sequence)

Recommended Name: Fc receptor-like B precursor

Size: 426 amino acids; 46904 Da

Subcellular location: Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted

Secondary accessions: A2A3J5 A2A3J7 Q5VXA6 Q6BAA0 Q6BAA1 Q6BAA2 Q6BAA3 Q8IXZ7

Alternative splicing: 5 isoforms: Q6BAA4-1 Q6BAA4-2 Q6BAA4-3 Q6BAA4-4 Q6BAA4-5

Explore the universe of human proteins at neXtProt for FCRLB: NX_Q6BAA4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6BAA4

FCRLB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001002901.1

ENSEMBL proteins:

ENSP00000356925 ENSP00000356923 ENSP00000356922 ENSP00000338598 ENSP00000356921

ENSP00000375999

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	Uscn Proteins for FCRLB

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	15815692
GO:0005783	endoplasmic reticulum	IEA	--

FCRLB for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FCRLB for domains About GeneDecksing

3 InterPro domains/families:

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q6BAA4

ProtoNet protein and cluster: Q6BAA4

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: FCRLB_HUMAN, Q6BAA4

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRLB

Animal Models:
Mouse knock-out Fcrlb^tm1Pdb for FCRLB
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fcrlb):

immune system

FCRLB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FCRLB

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FCRLB
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for FCRLB gene:

NM_001002901.2

Unigene Cluster for FCRLB:

Fc receptor-like B

Hs.517422 [show with all ESTs]

Unigene Representative Sequence: BC067080

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367948(uc001gbh.3 uc009wus.3 uc001gbi.3 uc001gbj.3 uc001gbk.3 uc001gbl.3 uc001gbm.3)

ENST00000367946 ENST00000367945 ENST00000336830 ENST00000367944 ENST00000495397(uc001gbn.4)

ENST00000392158

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Additional cDNA sequence:

AK055614.1 AK290733.1 AY670683.1 AY670684.1 AY670685.1 AY670686.1 AY670687.1 AY786314.1

BC038564.2 BC067080.1 DQ021957.1

5 DOTS entries:

DT.201600 DT.100811443 DT.121389680 DT.121389683 DT.100673387

24/36 AceView cDNA sequences (see all 36):

BI092705 BQ014028 BX280522 AY670686 BQ014014 AY670683 BC038564 AY670684

AI817123 AA746047 NM_001002901 AY670685 AY670687 CA442500 BE895345 NM_152378

BE965639 AI393356 BC067080 AL519963 BQ232294 AI432698 AK055614 AA693721

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FCRLB About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7
SP1:
SP2:
SP3:											-
SP4:											-		-

ECgene alternative splicing isoforms for FCRLB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FCRLB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCGCAGCC

About this image

FCRLB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FCRLB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCRLB

SOURCE GeneReport for Unigene cluster: Hs.517422

UniProtKB/Swiss-Prot: FCRLB_HUMAN, Q6BAA4

Tissue specificity: Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and

placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein level)

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FCRLB gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fcrlb^{1 , 5}	Fc receptor-like B^{1, 5}	83.45(n)¹ 83.61(a)¹		1 (77.56 cM)⁵ 435653¹ NM_001029984.2¹ NP_001025155.2¹ 170907273⁵
chicken (Gallus gallus)	Aves	--	--	27(a)	1 → many	25(1707231-1709870)

ENSEMBL Gene Tree for FCRLB (if available)
TreeFam Gene Tree for FCRLB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FCRLB gene

FCGR2B² FCGR1B² FCGR3B² FCRL2² FCRL1² FCRL4² FCRL5² FCRLA²

FCGR1A² FCGR2A² FCGR3A² FCRL3² FCER1A² FCRL6²

11 SIMAP similar genes for FCRLB using alignment to 1 protein entry: FCRLB_HUMAN:

DKFZp686L20250 FCER1A FCGR1B FCGR2A FCRL3 FCRL5

FCGR1A FCRLA FCGR2B FCGR3B Fc-gamma receptor IIIB

FCRLB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71634907^1,2	C,F,	--	161690593(+)	`NNNNTC/ATGCAT`	1	--	us2k¹		3		NA	124
rs138952183^1,2		--	161690639(+)	`AGTCCC/TAGATG`	1	--	us2k¹		0	--	--	--	--
rs115389814^1,2	F,	--	161690704(+)	`TATTTC/TGTGGG`	1	--	us2k¹		1		WA	118
rs149278467^1,2		--	161690705(+)	`ATTTCA/GTGGGA`	1	--	us2k¹		0	--	--	--	--
rs114320833^1,2		--	161690764(+)	`TGGTTC/TCAGAG`	1	--	us2k¹		1		WA	118
rs6427622^1,2	C,F,H,	--	161690781(+)	`AGGGAA/CGACTA`	1	--	us2k¹		19		NA NS EA WA CSA	927
rs189672017^1,2		--	161690829(+)	`TGAATC/TGAGTA`	1	--	us2k¹		0	--	--	--	--
rs144480385^1,2		--	161690932(+)	`TTACCA/GTTGAG`	1	--	us2k¹		0	--	--	--	--
rs148407282^1,2		--	161691091(+)	`ATCATC/TCCTGT`	1	--	us2k¹		0	--	--	--	--
rs141608559^1,2		--	161691155(+)	`ATGTCC/TCTACT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FCRLB (161691353 - 161697933 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FCRLB
1 CNV: 6791

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FCRLB for disorders           About GeneDecksing

OMIM gene information: 609251    OMIM disorders: --

2 diseases for FCRLB:    About MalaCards

tonsillitis melanoma

Human Genome Epidemiology (HuGE) Navigator: FCRLB (3 documents)

Export disorders for FCRLB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FCRLB gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FCRLB)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of the human FCRL2 gene. (PubMed id 15676285)^{1, 2, 3, 9} Chikaev N.A.... Taranin A.V. (2005)
FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. (PubMed id 16263223)^{1, 2, 9} Masuda K.... Burrows P.D. (2005)
A new Fc receptor homolog, FREB2, found in germinal center B cells. (PubMed id 15815692)^{1, 2} Wilson T.J. and Colonna M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)¹ Luke M.M....Psaty B.M. (2009)
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)¹ Shiffman D....Psaty B.M. (2008)
The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. (PubMed id 17273841)¹ Taylor A.I....Calvert R.A. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients. (PubMed id 15551350)² Inozume T.... Kawakami Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 127943	HGNC: 26431	AceView: FLJ31052	Ensembl:ENSG00000162746	euGenes: HUgn127943
ECgene: FCRLB	H-InvDB: FCRLB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FCRLB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FCRLB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FCRLB gene:
Search GeneIP for patents involving FCRLB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for FCRLB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCRLB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCRLB
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	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	OriGene Custom Antibody Services for FCRLB		OriGene Custom Protein Services for FCRLB
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCRLB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCRLB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRLB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCRLB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCRLB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCRLB

	GenScript Custom Purified and Recombinant Proteins Services for FCRLB		GenScript cDNA clones with any tag delivered in your preferred vector for FCRLB
	GenScript Custom Assay Services for FCRLB		GenScript Custom Superior Antibodies Services for FCRLB
	GenScript Custom overexpressing Cell Line Services for FCRLB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRLB

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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FCRLB Gene

Fc receptor-like B

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FCRLB Gene

Fc receptor-like B

Aliasesfor FCRLB gene

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Protein Domains /Familiesfor FCRLB gene

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for FCRLB gene

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for FCRLB gene

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for FCRLB gene

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