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Aliases for FCRLB Gene

Aliases for FCRLB Gene

  • Fc Receptor Like B 2 3 5
  • Fc Receptor-Like And Mucin-Like Protein 2 3 4
  • Fc Receptor-Related Protein Y 3 4
  • Fc Receptor-Like Protein 2 3 4
  • Fc Receptor-Like B 2 3
  • FCRLM2 3 4
  • FREB-2 3 4
  • FcRL2 3 4
  • FREB2 3 4
  • FcRY 3 4
  • Fc Receptor Homolog Expressed In B Cells Protein 2 3
  • Fc Receptor Homolog Expressed In B-Cells Protein 2 4
  • Fc Receptor-Like And Mucin-Like 2 2
  • FCRLY 3

External Ids for FCRLB Gene

Previous HGNC Symbols for FCRLB Gene

  • FCRLM2

Previous GeneCards Identifiers for FCRLB Gene

  • GC01P159958
  • GC01P161691
  • GC01P132936

Summaries for FCRLB Gene

Entrez Gene Summary for FCRLB Gene

  • FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FCRLB Gene

FCRLB (Fc Receptor Like B) is a Protein Coding gene. An important paralog of this gene is FCRL3.

Additional gene information for FCRLB Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRLB Gene

Genomics for FCRLB Gene

GeneHancer (GH) Regulatory Elements for FCRLB Gene

Promoters and enhancers for FCRLB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I161721 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 564.5 +0.4 441 1.7 PKNOX1 ATF1 ARNT TCF12 ZNF766 FOS ATF7 NCOA1 REST ZNF592 FCRLB FCGR2B RN7SL466P
GH01I161725 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 14 +5.8 5839 3.5 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 FCRLA FCRLB ATF6 DEDD B4GALT3 FCGR2B RN7SL466P
GH01I161705 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11 -14.4 -14399 3.2 PKNOX1 ATF1 ARNT IRF4 TCF12 ZNF766 FOS ATF7 RUNX3 JUNB FCRLA FCRLB FCGR2B HSPA7 GC01M161708
GH01I161736 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +15.0 15043 0.9 SRF ARNT JUNB FOXA1 SP1 FOSL1 IKZF1 FOS FOSL2 ZZZ3 RN7SL466P FCRLB ENSG00000272574 DDR2 FCRLA FCGR2A FCGR2B DUSP12 ATF6 HSPA6
GH01I161539 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.8 -179.7 -179749 4.8 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 POLR2B GC01P161541 TRN-GTT1-1 DUSP12 FCGR2C USP21 ARHGAP30 FCGR2A FCRLB SLAMF7 LY9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FCRLB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCRLB gene promoter:

Genomic Locations for FCRLB Gene

Genomic Locations for FCRLB Gene
6,600 bases
Plus strand

Genomic View for FCRLB Gene

Genes around FCRLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRLB Gene

Proteins for FCRLB Gene

  • Protein details for FCRLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like B
    Protein Accession:
    Secondary Accessions:
    • A2A3J5
    • A2A3J7
    • Q5VXA6
    • Q6BAA0
    • Q6BAA1
    • Q6BAA2
    • Q6BAA3
    • Q8IXZ7

    Protein attributes for FCRLB Gene

    426 amino acids
    Molecular mass:
    46904 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRLB Gene


neXtProt entry for FCRLB Gene

Post-translational modifications for FCRLB Gene

No data available for DME Specific Peptides for FCRLB Gene

Domains & Families for FCRLB Gene

Gene Families for FCRLB Gene

Protein Domains for FCRLB Gene

Suggested Antigen Peptide Sequences for FCRLB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCRLB: view

No data available for UniProtKB/Swiss-Prot for FCRLB Gene

Function for FCRLB Gene

Phenotypes From GWAS Catalog for FCRLB Gene

Phenotypes for FCRLB Gene

genes like me logo Genes that share phenotypes with FCRLB: view

Animal Models for FCRLB Gene

MGI Knock Outs for FCRLB:

Animal Model Products

CRISPR Products

miRNA for FCRLB Gene

miRTarBase miRNAs that target FCRLB

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCRLB Gene

Localization for FCRLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRLB Gene

Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted. {ECO:0000269 PubMed:15676285}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRLB gene
Compartment Confidence
plasma membrane 3
extracellular 3
endoplasmic reticulum 3
cytosol 2
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FCRLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15815692
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with FCRLB: view

Pathways & Interactions for FCRLB Gene

SuperPathways for FCRLB Gene

No Data Available

Interacting Proteins for FCRLB Gene

Gene Ontology (GO) - Biological Process for FCRLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050777 negative regulation of immune response IEA --
genes like me logo Genes that share ontologies with FCRLB: view

No data available for Pathways by source and SIGNOR curated interactions for FCRLB Gene

Drugs & Compounds for FCRLB Gene

No Compound Related Data Available

Transcripts for FCRLB Gene

Unigene Clusters for FCRLB Gene

Fc receptor-like B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRLB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP3: -
SP4: - -

Relevant External Links for FCRLB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRLB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRLB Gene

Protein differential expression in normal tissues from HIPED for FCRLB Gene

This gene is overexpressed in Heart (34.5) and Peripheral blood mononuclear cells (34.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRLB Gene

Protein tissue co-expression partners for FCRLB Gene

NURSA nuclear receptor signaling pathways regulating expression of FCRLB Gene:


SOURCE GeneReport for Unigene cluster for FCRLB Gene:


mRNA Expression by UniProt/SwissProt for FCRLB Gene:

Tissue specificity: Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein level).

Evidence on tissue expression from TISSUES for FCRLB Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with FCRLB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRLB Gene

Orthologs for FCRLB Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCRLB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCRLB 33 34
  • 99.61 (n)
(Canis familiaris)
Mammalia FCRLB 33 34
  • 86.67 (n)
(Bos Taurus)
Mammalia FCRLB 33 34
  • 86.33 (n)
(Rattus norvegicus)
Mammalia Fcrlb 33
  • 83.77 (n)
(Mus musculus)
Mammalia Fcrlb 33 16 34
  • 83.45 (n)
(Monodelphis domestica)
Mammalia FCRLB 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia FCRLB 34
  • 52 (a)
Species where no ortholog for FCRLB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRLB Gene

Gene Tree for FCRLB (if available)
Gene Tree for FCRLB (if available)

Paralogs for FCRLB Gene

(11) SIMAP similar genes for FCRLB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FCRLB: view

Variants for FCRLB Gene

Sequence variations from dbSNP and Humsavar for FCRLB Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000292347 -- 161,727,799(+) G/C 3_prime_UTR_variant
rs1000600589 -- 161,726,144(+) A/G intron_variant
rs1001056069 -- 161,726,511(+) C/T intron_variant
rs1001151862 -- 161,724,570(+) T/C intron_variant
rs1001245698 -- 161,721,833(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FCRLB Gene

Variant ID Type Subtype PubMed ID
esv2718895 CNV deletion 23290073
esv33393 CNV gain+loss 17666407
nsv428257 CNV loss 18775914
nsv464184 CNV gain 19166990
nsv464195 CNV loss 19166990
nsv516773 CNV gain 19592680
nsv548075 CNV gain 21841781
nsv548076 CNV loss 21841781

Variation tolerance for FCRLB Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.95; 83.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCRLB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRLB Gene

Disorders for FCRLB Gene

Additional Disease Information for FCRLB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FCRLB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCRLB Gene

Publications for FCRLB Gene

  1. Cloning and characterization of the human FCRL2 gene. (PMID: 15676285) Chikaev NA … Taranin AV (Genomics 2005) 2 3 4 22 58
  2. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. (PMID: 16263223) Masuda K … Burrows PD (Gene 2005) 3 4 22 58
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58
  5. A new Fc receptor homolog, FREB2, found in germinal center B cells. (PMID: 15815692) Wilson TJ … Colonna M (Genes and immunity 2005) 3 4 58

Products for FCRLB Gene

Sources for FCRLB Gene

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