Aliases for FCRLB Gene
Aliases for FCRLB Gene
External Ids for FCRLB Gene
- HGNC: 26431
- Entrez Gene: 127943
- Ensembl: ENSG00000162746
- OMIM: 609251
- UniProtKB: Q6BAA4
Previous HGNC Symbols for FCRLB Gene
- FCRLM2
Previous GeneCards Identifiers for FCRLB Gene
- GC01P159958
- GC01P161691
- GC01P132936
Summaries for FCRLB Gene
-
FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FCRLB Gene
FCRLB (Fc Receptor Like B) is a Protein Coding gene. An important paralog of this gene is FCRL3.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRLB Gene
Genomics for FCRLB Gene
Regulatory Elements for FCRLB Gene
Enhancers for FCRLB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCRLB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FCRLB Gene
- Chromosome:
- 1
- Start:
- 161,721,544 bp from pter
- End:
- 161,728,143 bp from pter
- Size:
- 6,600 bases
- Orientation:
- Plus strand
Genomic View for FCRLB Gene
Genes around FCRLB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC
FCRLB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCRLB Gene
Proteins for FCRLB Gene
-
Protein details for FCRLB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6BAA4-FCRLB_HUMAN
- Recommended name:
- Fc receptor-like B
- Protein Accession:
- Q6BAA4
- A2A3J5
- A2A3J7
- Q5VXA6
- Q6BAA0
- Q6BAA1
- Q6BAA2
- Q6BAA3
- Q8IXZ7
Protein attributes for FCRLB Gene
- Size:
- 426 amino acids
- Molecular mass:
- 46904 Da
- Quaternary structure:
- No Data Available
Protein Expression for FCRLB Gene
Post-translational modifications for FCRLB Gene
Other Protein References for FCRLB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FCRLB (FCRLB/FCRY)
- Novus Biologicals Antibodies for FCRLB
-
Abcam antibodies for FCRLB
- Invitrogen Antibodies for FCRLB
- Search GeneTex for Antibodies for FCRLB
Protein Products
- R&D Systems Proteins and Enzymes for FCRLB (FCRLB/FCRY)
-
OriGene Purified Proteins for FCRLB
- Search Origene for MassSpec and Protein Over-expression Lysates for FCRLB
- Origene Custom Protein Services for FCRLB
- Search GeneTex for Proteins for FCRLB
-
Abcam proteins for FCRLB
Assay Products
No data available for DME Specific Peptides for FCRLB Gene
Domains & Families for FCRLB Gene
Gene Families for FCRLB Gene
Protein Domains for FCRLB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCRLB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCRLB Gene
Function for FCRLB Gene
Phenotypes for FCRLB Gene
- MGI mutant phenotypes for FCRLB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FCRLB:
Animal Models for FCRLB Gene
- MGI Knock Outs for FCRLB:
-
- Fcrlb tm1Pdb
Animal Model Products
-
Taconic Biosciences Mouse Models for FCRLB
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRLB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRLB gene
- Search ViGene Biosciences for FCRLB
CRISPR Products
-
OriGene CRISPR knockouts for FCRLB
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRLB
- GenScript: Design CRISPR guide RNA sequences for FCRLB
miRNA for FCRLB Gene
- miRTarBase miRNAs that target FCRLB
miRNA Products
- Search ViGene Biosciences for FCRLB
Inhibitory RNA Products
- Origene siRNA and shRNA products in human, mouse, rat for FCRLB
- Browse OriGene Inhibitory RNA Products For FCRLB
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRLB gene
Clone Products
Cell Line Products
-
Horizon Cell Lines for FCRLB
-
ViGene Biosciences adenoviral particle packaged cDNA for FCRLB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRLB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRLB gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCRLB Gene
Localization for FCRLB Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCRLB Gene
- Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted. {ECO:0000269 PubMed:15676285}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| extracellular | 3 |
| endoplasmic reticulum | 3 |
| cytosol | 2 |
| lysosome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 15815692 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for FCRLB Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0050777 | negative regulation of immune response | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FCRLB Gene
Transcripts for FCRLB Gene
mRNA/cDNA for FCRLB Gene
- (6) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FCRLB
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRLB
- GenScript: Design CRISPR guide RNA sequences for FCRLB
miRNA Products
- Search ViGene Biosciences for FCRLB
Inhibitory RNA Products
- Origene siRNA and shRNA products in human, mouse, rat for FCRLB
- Browse OriGene Inhibitory RNA Products For FCRLB
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRLB gene
Clone Products
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | - | ||||||||||||||||
| SP4: | - | - |
Expression for FCRLB Gene
This gene is overexpressed in Heart (34.5) and Peripheral blood mononuclear cells (34.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRLB Gene
NURSA nuclear receptor signaling pathways regulating expression of FCRLB Gene:
FCRLBSOURCE GeneReport for Unigene cluster for FCRLB Gene:
Hs.517422mRNA Expression by UniProt/SwissProt for FCRLB Gene:
Q6BAA4-FCRLB_HUMAN
Tissue specificity:
Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein level).
Evidence on tissue expression from TISSUES for FCRLB Gene
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs for FCRLB
-
OriGene qPCR primer pairs and template standards for FCRLB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRLB Gene
Orthologs for FCRLB Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCRLB 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCRLB 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCRLB 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcrlb 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcrlb 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FCRLB 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FCRLB 35 |
|
OneToOne |
- Species where no ortholog for FCRLB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCRLB Gene
Paralogs for FCRLB Gene
(11) SIMAP similar genes for FCRLB Gene using alignment to 1 proteins:
Variants for FCRLB Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000292347 | -- | 161,727,799(+) | GTGTA(C/G)TGGCT | utr-variant-3-prime | |
| rs1000600589 | -- | 161,726,144(+) | CTGGG(A/G)CAGGA | intron-variant | |
| rs1001056069 | -- | 161,726,511(+) | TTTCC(C/T)CGTCC | intron-variant | |
| rs1001151862 | -- | 161,724,570(+) | CACAA(C/T)TTGTA | intron-variant | |
| rs1001245698 | -- | 161,721,833(+) | ATGCA(A/G)TGACT | upstream-variant-2KB, utr-variant-5-prime |
Residual Variation Intolerance Score:
93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.95;
83.96% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCRLB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCRLB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRLB Gene
Disorders for FCRLB Gene
Relevant External Links for FCRLB
No disorders were found for FCRLB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCRLB Gene
Publications for FCRLB Gene
- Cloning and characterization of the human FCRL2 gene. (PMID: 15676285) Chikaev N.A. … Taranin A.V. (Genomics 2005) 2 3 4 22 64
- FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. (PMID: 16263223) Masuda K. … Burrows P.D. (Gene 2005) 3 4 22 64
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
- A new Fc receptor homolog, FREB2, found in germinal center B cells. (PMID: 15815692) Wilson T.J. … Colonna M. (Genes Immun. 2005) 3 4 64
Products for FCRLB Gene
- R&D Systems Antibodies for FCRLB (FCRLB/FCRY)
- R&D Systems Proteins and Enzymes for FCRLB (FCRLB/FCRY)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FCRLB
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FCRLB
- Search Origene for MassSpec and Protein Over-expression Lysates for FCRLB
- Origene Custom Protein Services for FCRLB
- Origene shRNA and siRNA products in human, mouse, rat for FCRLB
- Browse OriGene Inhibitory RNA Products For FCRLB
- OriGene qPCR primer pairs and template standards for FCRLB
- OriGene qPCR primer pairs for FCRLB
- OriGene CRISPR knockouts for FCRLB
- OriGene ORF clones in human for FCRLB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FCRLB
- GenScript: Next-day shipping cDNA ORF clone for FCRLB in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FCRLB
- GenScript Custom Assay Services for FCRLB
- GenScript Custom overexpressing Cell Line Services for FCRLB
- GenScript: Design CRISPR guide RNA sequences for FCRLB
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FCRLB
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FCRLB
- Novus Biologicals proteins and lysates for FCRLB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FCRLB
- Abcam proteins for FCRLB
- Search for Assays for FCRLB at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for FCRLB
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FCRLB
- ViGene Biosciences adenoviral particle packaged cDNA for FCRLB gene
- ViGene Biosciences lentiviral particle packaged cDNA for FCRLB gene
- ViGene Biosciences ready-to-package AAV shRNAs for FCRLB gene
- Search ViGene Biosciences for FCRLB
- Horizon Cell Lines for FCRLB
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCRLB
- VectorBuilder custom plasmid, inducible vectors for FCRLB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCRLB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCRLB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer