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Aliases for FCRLA Gene

Aliases for FCRLA Gene

  • Fc Receptor Like A 2 3 5
  • Fc Receptor-Like And Mucin-Like Protein 1 3 4
  • Fc Receptor Homolog Expressed In B-Cells 3 4
  • Fc Receptor-Like And Mucin-Like 1 2 3
  • Fc Receptor-Related Protein X 3 4
  • Fc Receptor-Like Protein 3 4
  • Fc Receptor-Like A 2 3
  • FCRLM1 3 4
  • FcRL1 3 4
  • FCRL 3 4
  • FCRX 3 4
  • FREB 3 4
  • Fc Receptor Homolog Expressed In B Cells (FREB) 3
  • Fc Receptor Related Protein X 3
  • FCRLc1 3
  • FCRLc2 3
  • FCRLX 3
  • FCRLb 3
  • FCRLd 3
  • FCRLe 3

External Ids for FCRLA Gene

Previous HGNC Symbols for FCRLA Gene

  • FCRLM1

Previous GeneCards Identifiers for FCRLA Gene

  • GC01P159944
  • GC01P161676
  • GC01P132921

Summaries for FCRLA Gene

Entrez Gene Summary for FCRLA Gene

  • This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for FCRLA Gene

FCRLA (Fc Receptor Like A) is a Protein Coding gene. An important paralog of this gene is FCRLB.

UniProtKB/Swiss-Prot for FCRLA Gene

  • May be implicated in B-cell differentiation and lymphomagenesis.

Gene Wiki entry for FCRLA Gene

Additional gene information for FCRLA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRLA Gene

Genomics for FCRLA Gene

Regulatory Elements for FCRLA Gene

Enhancers for FCRLA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H161738 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16 +33.2 33170 3 PKNOX1 ATF1 ARNT YBX1 ZNF2 YY1 TCF12 ZNF143 ATF7 RUNX3 FCRLA FCGR2A DUSP12 ATF6 HSPA6 FCGR3A RN7SL466P
GH01H161725 1.3 ENCODE dbSUPER 21 +20.4 20412 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF143 FCRLA USP21 DUSP12 FCRLB PPOX ATF6 DEDD B4GALT3 FCGR2B RN7SL466P
GH01H161528 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -175.8 -175813 4 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 FOS DEK USP21 DUSP12 FCGR2C DEDD FCGR2A B4GALT3 PPOX FCRLA ATF6 FCGR2B
GH01H161729 1.3 Ensembl ENCODE dbSUPER 16.6 +23.4 23379 1 LEF1 TBL1XR1 JUN ETV1 ZNF175 BATF FOSL1 ZFHX2 EED ZSCAN29 FCRLA FCRLB DUSP12 RN7SL466P
GH01H161705 1.2 Ensembl ENCODE 17.5 +0.2 174 3 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 FOS ATF7 RUNX3 JUNB FCRLA FCRLB FCGR2B HSPA7 GC01M161708
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCRLA on UCSC Golden Path with GeneCards custom track

Genomic Location for FCRLA Gene

Chromosome:
1
Start:
161,706,972 bp from pter
End:
161,714,352 bp from pter
Size:
7,381 bases
Orientation:
Plus strand

Genomic View for FCRLA Gene

Genes around FCRLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRLA Gene

Proteins for FCRLA Gene

neXtProt entry for FCRLA Gene

Post-translational modifications for FCRLA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FCRLA Gene

Domains & Families for FCRLA Gene

Gene Families for FCRLA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCRLA Gene

Suggested Antigen Peptide Sequences for FCRLA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCRLA: view

No data available for UniProtKB/Swiss-Prot for FCRLA Gene

Function for FCRLA Gene

Molecular function for FCRLA Gene

UniProtKB/Swiss-Prot Function:
May be implicated in B-cell differentiation and lymphomagenesis.

Phenotypes From GWAS Catalog for FCRLA Gene

genes like me logo Genes that share phenotypes with FCRLA: view

Animal Models for FCRLA Gene

MGI Knock Outs for FCRLA:

Animal Model Products

  • Taconic Biosciences Mouse Models for FCRLA

CRISPR Products

miRNA for FCRLA Gene

miRTarBase miRNAs that target FCRLA

Clone Products

  • Applied Biological Materials Clones for FCRLA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCRLA Gene

Localization for FCRLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRLA Gene

Cytoplasm. Note=Seems not to be secreted. {ECO:0000269 PubMed:11891275}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRLA gene
Compartment Confidence
plasma membrane 4
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for FCRLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15815692
genes like me logo Genes that share ontologies with FCRLA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRLA Gene

Pathways & Interactions for FCRLA Gene

SuperPathways for FCRLA Gene

No Data Available

Interacting Proteins for FCRLA Gene

Gene Ontology (GO) - Biological Process for FCRLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with FCRLA: view

No data available for Pathways by source and SIGNOR curated interactions for FCRLA Gene

Drugs & Compounds for FCRLA Gene

No Compound Related Data Available

Transcripts for FCRLA Gene

Unigene Clusters for FCRLA Gene

Fc receptor-like A:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for FCRLA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FCRLA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6:
SP7: - - - -

Relevant External Links for FCRLA Gene

GeneLoc Exon Structure for
FCRLA
ECgene alternative splicing isoforms for
FCRLA

Expression for FCRLA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRLA Gene

This gene is overexpressed in Spleen (x10.7) and Small Intestine - Terminal Ileum (x4.9).

Protein differential expression in normal tissues from HIPED for FCRLA Gene

This gene is overexpressed in Blymphocyte (49.1) and Peripheral blood mononuclear cells (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRLA Gene



Protein tissue co-expression partners for FCRLA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCRLA Gene:

FCRLA

SOURCE GeneReport for Unigene cluster for FCRLA Gene:

Hs.266331

mRNA Expression by UniProt/SwissProt for FCRLA Gene:

Q7L513-FCRLA_HUMAN
Tissue specificity: Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.

Evidence on tissue expression from TISSUES for FCRLA Gene

  • Skin(4.5)
  • Blood(2.4)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with FCRLA: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRLA Gene

Orthologs for FCRLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRLA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCRLA 33 34
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia FCRLA 33 34
  • 83.24 (n)
dog
(Canis familiaris)
Mammalia FCRLA 33 34
  • 82.76 (n)
mouse
(Mus musculus)
Mammalia Fcrla 33 16 34
  • 77.48 (n)
rat
(Rattus norvegicus)
Mammalia Fcrla 33
  • 75.2 (n)
oppossum
(Monodelphis domestica)
Mammalia FCRLA 34
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FCRL2 34
  • 21 (a)
OneToMany
Species where no ortholog for FCRLA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRLA Gene

ENSEMBL:
Gene Tree for FCRLA (if available)
TreeFam:
Gene Tree for FCRLA (if available)

Paralogs for FCRLA Gene

genes like me logo Genes that share paralogs with FCRLA: view

Variants for FCRLA Gene

Sequence variations from dbSNP and Humsavar for FCRLA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000559520 -- 161,712,904(+) TTTCA(A/G)ACAGA intron-variant
rs1000930126 -- 161,712,590(+) ACTTG(A/G)CCTGA intron-variant
rs1001016103 -- 161,708,733(+) GGTAC(C/T)CCTAA intron-variant
rs1001401873 -- 161,707,537(+) CATCC(C/T)GAAAG intron-variant
rs1001880931 -- 161,712,382(+) GACAG(A/C)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRLA Gene

Variant ID Type Subtype PubMed ID
esv2758972 CNV gain+loss 17122850
esv33393 CNV gain+loss 17666407
nsv428257 CNV loss 18775914
nsv464184 CNV gain 19166990
nsv524449 CNV loss 19592680
nsv548075 CNV gain 21841781

Variation tolerance for FCRLA Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCRLA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCRLA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRLA Gene

Disorders for FCRLA Gene

Relevant External Links for FCRLA

Genetic Association Database (GAD)
FCRLA
Human Genome Epidemiology (HuGE) Navigator
FCRLA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCRLA

No disorders were found for FCRLA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCRLA Gene

Publications for FCRLA Gene

  1. FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. (PMID: 11754007) Mechetina LV … Taranin AV (European journal of immunology 2002) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients. (PMID: 15551350) Inozume T … Kawakami Y (International journal of cancer 2005) 3 4 60
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for FCRLA Gene

Sources for FCRLA Gene

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