Aliases for FCRLA Gene
Aliases for FCRLA Gene
External Ids for FCRLA Gene
- HGNC: 18504
- Entrez Gene: 84824
- Ensembl: ENSG00000132185
- OMIM: 606891
- UniProtKB: Q7L513
Previous HGNC Symbols for FCRLA Gene
- FCRLM1
Previous GeneCards Identifiers for FCRLA Gene
- GC01P159944
- GC01P161676
- GC01P132921
Summaries for FCRLA Gene
-
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for FCRLA Gene
FCRLA (Fc Receptor Like A) is a Protein Coding gene. An important paralog of this gene is FCRL6.
UniProtKB/Swiss-Prot for FCRLA Gene
-
May be implicated in B-cell differentiation and lymphomagenesis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRLA Gene
Genomics for FCRLA Gene
Regulatory Elements for FCRLA Gene
Enhancers for FCRLA Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCRLA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FCRLA Gene
- Chromosome:
- 1
- Start:
- 161,706,972 bp from pter
- End:
- 161,714,352 bp from pter
- Size:
- 7,381 bases
- Orientation:
- Plus strand
Genomic View for FCRLA Gene
Genes around FCRLA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC
FCRLA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCRLA Gene
Proteins for FCRLA Gene
-
Protein details for FCRLA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L513-FCRLA_HUMAN
- Recommended name:
- Fc receptor-like A
- Protein Accession:
- Q7L513
- A0N0M1
- A6NC03
- A6NL20
- F5H720
- F8W743
- G3V1J2
- Q5VXA1
- Q5VXA2
- Q5VXA3
- Q5VXA4
- Q5VXB0
- Q5VXB1
- Q8NEW4
- Q8WXH3
- Q96PC6
- Q96PJ0
- Q96PJ1
- Q96PJ2
- Q96PJ4
- Q9BR57
Protein attributes for FCRLA Gene
- Size:
- 359 amino acids
- Molecular mass:
- 38927 Da
- Quaternary structure:
-
- Monomer or homodimer; disulfide-linked.
Protein Expression for FCRLA Gene
Post-translational modifications for FCRLA Gene
Other Protein References for FCRLA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FCRLA (FCRLA)
- Novus Biologicals Antibodies for FCRLA
-
Abcam antibodies for FCRLA
- Invitrogen Antibodies for FCRLA
- antibodies-online Antibodies for FCRLA: See all 20
- GeneTex FCRLA antibody for FCRLA
-
Santa Cruz Biotechnology (SCBT) Antibodies for FCRLA
Protein Products
-
OriGene Purified Proteins for FCRLA
- Search Origene for MassSpec and Protein Over-expression Lysates for FCRLA
- Origene Custom Protein Services for FCRLA
- antibodies-online Proteins for FCRLA: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FCRLA
-
Abcam proteins for FCRLA
Assay Products
No data available for DME Specific Peptides for FCRLA Gene
Domains & Families for FCRLA Gene
Gene Families for FCRLA Gene
Protein Domains for FCRLA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCRLA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCRLA Gene
Function for FCRLA Gene
Molecular function for FCRLA Gene
- UniProtKB/Swiss-Prot Function:
- May be implicated in B-cell differentiation and lymphomagenesis.
Phenotypes for FCRLA Gene
- MGI mutant phenotypes for FCRLA:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FCRLA:
Animal Model Products
-
Taconic Biosciences Mouse Models for FCRLA
CRISPR Products
-
OriGene CRISPR knockouts for FCRLA
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRLA
- GenScript: Design CRISPR guide RNA sequences for FCRLA
miRNA for FCRLA Gene
- miRTarBase miRNAs that target FCRLA
miRNA Products
- Search ViGene Biosciences for FCRLA
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FCRLA
- Browse OriGene Inhibitory RNA Products For FCRLA
Clone Products
-
OriGene ORF clones in human for FCRLA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for FCRLA
Cell Line Products
-
Horizon Cell Lines for FCRLA
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCRLA Gene
Localization for FCRLA Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCRLA Gene
- Cytoplasm. Note=Seems not to be secreted. {ECO:0000269 PubMed:11891275}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 15815692 |
Pathways & Interactions for FCRLA Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FCRLA Gene
Transcripts for FCRLA Gene
mRNA/cDNA for FCRLA Gene
- (11) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (146) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCRLA Gene
- Fc receptor-like A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FCRLA
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRLA
- GenScript: Design CRISPR guide RNA sequences for FCRLA
miRNA Products
- Search ViGene Biosciences for FCRLA
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FCRLA
- Browse OriGene Inhibitory RNA Products For FCRLA
Clone Products
-
OriGene ORF clones in human for FCRLA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for FCRLA
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | - | - | - | - |
Expression for FCRLA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Mature B-Cells Peripheral Blood
- Conventional Dendritic Cells I Spleen
- Spleen (Hematopoietic System)
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for FCRLA Gene
This gene is overexpressed in Spleen (x10.7) and Small Intestine - Terminal Ileum (x4.9).
This gene is overexpressed in Blymphocyte (49.1) and Peripheral blood mononuclear cells (19.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRLA Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FCRLA Gene:
FCRLASOURCE GeneReport for Unigene cluster for FCRLA Gene:
Hs.266331mRNA Expression by UniProt/SwissProt for FCRLA Gene:
Q7L513-FCRLA_HUMAN
Tissue specificity:
Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.
Evidence on tissue expression from TISSUES for FCRLA Gene
- Skin(4.5)
- Blood(2.4)
- Lymph node(2.3)
Primer Products
-
OriGene qPCR primer pairs for FCRLA
-
OriGene qPCR primer pairs and template standards for FCRLA
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRLA Gene
Orthologs for FCRLA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCRLA 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCRLA 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCRLA 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcrla 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcrla 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FCRLA 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | FCRL2 35 |
|
OneToMany |
- Species where no ortholog for FCRLA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCRLA Gene
Paralogs for FCRLA Gene
(4) SIMAP similar genes for FCRLA Gene using alignment to 9 proteins:
Variants for FCRLA Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000559520 | -- | 161,712,904(+) | TTTCA(A/G)ACAGA | intron-variant | |
| rs1000930126 | -- | 161,712,590(+) | ACTTG(A/G)CCTGA | intron-variant | |
| rs1001016103 | -- | 161,708,733(+) | GGTAC(C/T)CCTAA | intron-variant | |
| rs1001401873 | -- | 161,707,537(+) | CATCC(C/T)GAAAG | intron-variant | |
| rs1001880931 | -- | 161,712,382(+) | GACAG(A/C)ACAAA | intron-variant |
Residual Variation Intolerance Score:
84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.58;
65.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCRLA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCRLA
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRLA Gene
Disorders for FCRLA Gene
Relevant External Links for FCRLA
No disorders were found for FCRLA Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCRLA Gene
Publications for FCRLA Gene
- FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. (PMID: 11754007) Mechetina L.V. … Taranin A.V. (Eur. J. Immunol. 2002) 2 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients. (PMID: 15551350) Inozume T. … Kawakami Y. (Int. J. Cancer 2005) 3 4 64
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for FCRLA Gene
- R&D Systems Antibodies for FCRLA (FCRLA)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for FCRLA
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FCRLA
- Search Origene for MassSpec and Protein Over-expression Lysates for FCRLA
- Origene Custom Protein Services for FCRLA
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCRLA
- Browse OriGene Inhibitory RNA Products For FCRLA
- OriGene qPCR primer pairs and template standards for FCRLA
- OriGene qPCR primer pairs for FCRLA
- OriGene CRISPR knockouts for FCRLA
- OriGene ORF clones in human for FCRLA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FCRLA in any vector
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- GenScript Custom overexpressing Cell Line Services for FCRLA
- GenScript: Design CRISPR guide RNA sequences for FCRLA
- Design optimal peptide antigens
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FCRLA
- Novus Biologicals proteins and lysates for FCRLA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FCRLA
- Abcam proteins for FCRLA
- Search for Assays for FCRLA at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for FCRLA
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for FCRLA: See all 20
- Search antibodies-online for kits
- antibodies-online Proteins for FCRLA: See all 6
- Search antibodies-online for peptides
- GeneTex FCRLA antibody for FCRLA
- Search GeneTex for Proteins for FCRLA
- Search ViGene Biosciences for FCRLA
- Santa Cruz Biotechnology (SCBT) Antibodies for FCRLA
- Search Santa Cruz Biotechnology (SCBT) for FCRLA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FCRLA
- Horizon Cell Lines for FCRLA
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCRLA
- VectorBuilder custom plasmid, inducible vectors for FCRLA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCRLA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCRLA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer