Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FCRLA Gene

Aliases for FCRLA Gene

  • Fc Receptor-Like A 2 3
  • FREB 3 4 6
  • Fc Receptor-Like And Mucin-Like Protein 1 3 4
  • Fc Receptor Homolog Expressed In B-Cells 3 4
  • Fc Receptor-Like And Mucin-Like 1 2 3
  • Fc Receptor-Related Protein X 3 4
  • Fc Receptor-Like Protein 3 4
  • FCRLM1 3 4
  • FCRL1 3 4
  • FCRL 3 4
  • FCRX 3 4
  • Fc Receptor Homolog Expressed In B Cells (FREB) 3
  • Fc Receptor Related Protein X 3
  • FCRLc1 3
  • FCRLc2 3
  • FCRLX 3
  • FCRLb 3
  • FCRLd 3
  • FCRLe 3

External Ids for FCRLA Gene

Previous Symbols for FCRLA Gene

  • FCRLM1

Summaries for FCRLA Gene

Entrez Gene Summary for FCRLA Gene

  • This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for FCRLA Gene

FCRLA (Fc Receptor-Like A) is a Protein Coding gene. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCRLA Gene

  • May be implicated in B-cell differentiation and lymphomagenesis.

Gene Wiki entry for FCRLA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRLA Gene

Genomics for FCRLA Gene

Genomic Location for FCRLA Gene

Start:
161,706,972 bp from pter
End:
161,714,352 bp from pter
Size:
7,381 bases
Orientation:
Plus strand

Genomic View for FCRLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCRLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRLA Gene

Regulatory Elements for FCRLA Gene

Proteins for FCRLA Gene

neXtProt entry for FCRLA Gene

Proteomics data for FCRLA Gene at MOPED

Post-translational modifications for FCRLA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FCRLA Gene

Domains for FCRLA Gene

Gene Families for FCRLA Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCRLA Gene

Suggested Antigen Peptide Sequences for FCRLA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L513

UniProtKB/Swiss-Prot:

FCRLA_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q7L513
genes like me logo Genes that share domains with FCRLA: view

Function for FCRLA Gene

Molecular function for FCRLA Gene

UniProtKB/Swiss-Prot Function: May be implicated in B-cell differentiation and lymphomagenesis.

Gene Ontology (GO) - Molecular Function for FCRLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FCRLA: view
genes like me logo Genes that share phenotypes with FCRLA: view

miRNA for FCRLA Gene

miRTarBase miRNAs that target FCRLA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FCRLA Gene

Localization for FCRLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRLA Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCRLA Gene COMPARTMENTS Subcellular localization image for FCRLA gene
Compartment Confidence
extracellular 4
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for FCRLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 15815692
genes like me logo Genes that share ontologies with FCRLA: view

Pathways for FCRLA Gene

SuperPathways for FCRLA Gene

No Data Available

Interacting Proteins for FCRLA Gene

Selected Interacting proteins: Q7L513-FCRLA_HUMAN for FCRLA Gene via I2D

Symbol External ID(s) Details
TRAF2

Gene Ontology (GO) - Biological Process for FCRLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with FCRLA: view

No data available for Pathways by source for FCRLA Gene

Transcripts for FCRLA Gene

Unigene Clusters for FCRLA Gene

Fc receptor-like A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCRLA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6:
SP7: - - - -

Relevant External Links for FCRLA Gene

GeneLoc Exon Structure for
FCRLA
ECgene alternative splicing isoforms for
FCRLA

Expression for FCRLA Gene

mRNA expression in normal human tissues for FCRLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRLA Gene

This gene is overexpressed in Spleen (10.7) and Small Intestine - Terminal Ileum (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FCRLA Gene

SOURCE GeneReport for Unigene cluster for FCRLA Gene Hs.266331

mRNA Expression by UniProt/SwissProt for FCRLA Gene

Q7L513-FCRLA_HUMAN
Tissue specificity: Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.
genes like me logo Genes that share expressions with FCRLA: view

Orthologs for FCRLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRLA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCRLA 35
  • 99.38 (n)
  • 98.94 (a)
FCRLA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCRLA 35
  • 83.24 (n)
  • 75 (a)
FCRLA 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCRLA 35
  • 82.76 (n)
  • 74.93 (a)
FCRLA 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcrla 35
  • 77.48 (n)
  • 70.87 (a)
Fcrla 16
Fcrla 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCRLA 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fcrla 35
  • 75.2 (n)
  • 67.65 (a)
chicken
(Gallus gallus)
Aves FCRL2 36
  • 21 (a)
OneToMany
Species with no ortholog for FCRLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRLA Gene

ENSEMBL:
Gene Tree for FCRLA (if available)
TreeFam:
Gene Tree for FCRLA (if available)

Paralogs for FCRLA Gene

genes like me logo Genes that share paralogs with FCRLA: view

Variants for FCRLA Gene

Sequence variations from dbSNP and Humsavar for FCRLA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11746 - 161,713,346(+) CCACC(A/G)GAAGC missense, reference
rs13661 -- 161,713,547(+) GAGAA(C/T)TAGAG utr-variant-3-prime
rs14833 -- 161,714,251(-) TTTTG(G/T)TTCTC utr-variant-3-prime
rs1104911 -- 161,714,179(-) ctttt(C/T)aaata utr-variant-3-prime
rs1105238 -- 161,711,871(-) ATGCA(C/G/T)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRLA Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
dgv135e1 CNV Complex 17122850
esv33393 CNV Gain+Loss 17666407
dgv138e1 CNV Complex 17122850
nsv464184 CNV Gain 19166990
nsv524449 CNV Loss 19592680

Relevant External Links for FCRLA Gene

HapMap Linkage Disequilibrium report
FCRLA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRLA Gene

Disorders for FCRLA Gene

Relevant External Links for FCRLA

Genetic Association Database (GAD)
FCRLA
Human Genome Epidemiology (HuGE) Navigator
FCRLA
genes like me logo Genes that share disorders with FCRLA: view

No data available for UniProtKB/Swiss-Prot for FCRLA Gene

Publications for FCRLA Gene

  1. FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. (PMID: 11754007) Mechetina L.V. … Taranin A.V. (Eur. J. Immunol. 2002) 2 3 4
  2. An unusual Fc receptor-related protein expressed in human centroblasts. (PMID: 11891275) Facchetti F. … Colonna M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  3. Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells. (PMID: 12202404) Davis R.S. … Burrows P.D. (Int. Immunol. 2002) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for FCRLA Gene

Sources for FCRLA Gene

Back to Top

Content