Aliases for FCRL6 Gene
Aliases for FCRL6 Gene
External Ids for FCRL6 Gene
- HGNC: 31910
- Entrez Gene: 343413
- Ensembl: ENSG00000181036
- OMIM: 613562
- UniProtKB: Q6DN72
Previous GeneCards Identifiers for FCRL6 Gene
- GC01P156584
- GC01P158036
- GC01P131128
Summaries for FCRL6 Gene
GeneCards Summary for FCRL6 Gene
FCRL6 (Fc Receptor Like 6) is a Protein Coding gene. Diseases associated with FCRL6 include Viral Pneumonia. GO annotations related to this gene include protein phosphatase binding. An important paralog of this gene is FCRL3.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL6 Gene
Genomics for FCRL6 Gene
Regulatory Elements for FCRL6 Gene
Enhancers for FCRL6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCRL6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCRL6 gene promoter:
Regulatory Element Products
Genomic Location for FCRL6 Gene
- Chromosome:
- 1
- Start:
- 159,800,511 bp from pter
- End:
- 159,816,257 bp from pter
- Size:
- 15,747 bases
- Orientation:
- Plus strand
Genomic View for FCRL6 Gene
Genes around FCRL6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.2 by Ensembl
- 1q23.2 by Entrez Gene
- 1q23.2 by HGNC
FCRL6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCRL6 Gene
Proteins for FCRL6 Gene
-
Protein details for FCRL6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6DN72-FCRL6_HUMAN
- Recommended name:
- Fc receptor-like protein 6
- Protein Accession:
- Q6DN72
- A1KXW6
- A2A4D6
- Q6DN73
- Q6XRC3
- Q6ZNI1
Protein attributes for FCRL6 Gene
- Size:
- 434 amino acids
- Molecular mass:
- 47748 Da
- Quaternary structure:
-
- Interacts with PTPN11.
Protein Expression for FCRL6 Gene
Post-translational modifications for FCRL6 Gene
- Phosphorylated on Tyr residue, inducing association with PTPN11.
- Glycosylation at Asn65 and isoforms=2, 3, 4273
- Modification sites at PhosphoSitePlus
Other Protein References for FCRL6 Gene
Antibody Products
- R&D Systems Antibodies for FCRL6 (FCRL6/FcRH6)
- Novus Biologicals Antibodies for FCRL6
- Invitrogen Antibodies for FCRL6
- GeneTex FCRL6 antibody for FCRL6
Protein Products
-
OriGene Purified Proteins for FCRL6
- Search Origene for MassSpec and Protein Over-expression Lysates for FCRL6
- Origene Custom Protein Services for FCRL6
- Search GeneTex for Proteins for FCRL6
Assay Products
No data available for DME Specific Peptides for FCRL6 Gene
Domains & Families for FCRL6 Gene
Gene Families for FCRL6 Gene
Protein Domains for FCRL6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCRL6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6DN72UniProtKB/Swiss-Prot:
FCRL6_HUMAN :- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
- Domain:
-
- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
Function for FCRL6 Gene
Phenotypes for FCRL6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRL6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL6 gene
- Search ViGene Biosciences for FCRL6
CRISPR Products
-
OriGene CRISPR knockouts for FCRL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRL6
- GenScript: Design CRISPR guide RNA sequences for FCRL6
miRNA Products
- Search ViGene Biosciences for FCRL6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCRL6
- Browse OriGene Inhibitory RNA Products For FCRL6
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL6 gene
Clone Products
- Sino Biological Human cDNA Clone for FCRL6
- R&D Systems cDNA Clones for FCRL6 (FCRL6/FcRH6)
Cell Line Products
-
Horizon Cell Lines for FCRL6
-
ViGene Biosciences adenoviral particle packaged cDNA for FCRL6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRL6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL6 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL6 Gene
Localization for FCRL6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCRL6 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| peroxisome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009897 | external side of plasma membrane | IDA | 17213291 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for FCRL6 Gene
No data available for Pathways by source and SIGNOR curated interactions for FCRL6 Gene
Transcripts for FCRL6 Gene
mRNA/cDNA for FCRL6 Gene
- (10) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FCRL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRL6
- GenScript: Design CRISPR guide RNA sequences for FCRL6
miRNA Products
- Search ViGene Biosciences for FCRL6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCRL6
- Browse OriGene Inhibitory RNA Products For FCRL6
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL6 gene
Clone Products
- Sino Biological Human cDNA Clone for FCRL6
- R&D Systems cDNA Clones for FCRL6 (FCRL6/FcRH6)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: |
Expression for FCRL6 Gene
mRNA differential expression in normal tissues according to GTEx for FCRL6 Gene
This gene is overexpressed in Whole Blood (x28.5) and Spleen (x6.5).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FCRL6 Gene:
FCRL6SOURCE GeneReport for Unigene cluster for FCRL6 Gene:
Hs.196955mRNA Expression by UniProt/SwissProt for FCRL6 Gene:
Q6DN72-FCRL6_HUMAN
Tissue specificity:
Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells.
Evidence on tissue expression from TISSUES for FCRL6 Gene
- Spleen(4.2)
Primer Products
-
OriGene qPCR primer pairs for FCRL6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL6 Gene
Orthologs for FCRL6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCRL6 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCRL6 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcrl6 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcrl6 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCRL6 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FCRL6 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | FCRL2 35 |
|
OneToMany |
- Species where no ortholog for FCRL6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCRL6 Gene
Paralogs for FCRL6 Gene
(4) SIMAP similar genes for FCRL6 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for FCRL6 Gene
Variants for FCRL6 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000197082 | -- | 159,813,977(+) | TTTTA(C/T)AGAAA | intron-variant | |
| rs1000226973 | -- | 159,800,697(+) | AAAAA(A/T)GCCTG | intron-variant, upstream-variant-2KB | |
| rs1000436174 | -- | 159,803,650(+) | AGGAA(C/T)AGCCC | intron-variant, nc-transcript-variant | |
| rs1000440258 | -- | 159,803,334(+) | TTTTT(A/G)TTTAA | intron-variant, nc-transcript-variant | |
| rs1000564714 | -- | 159,814,933(+) | CTGGG(C/T)CTAAT | intron-variant |
Residual Variation Intolerance Score:
90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.17;
80.79% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCRL6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL6 Gene
Disorders for FCRL6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| viral pneumonia |
|
|
Search FCRL6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FCRL6
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FCRL6
No data available for UniProtKB/Swiss-Prot and Genatlas for FCRL6 Gene
Publications for FCRL6 Gene
- FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. (PMID: 17213291) Wilson T.J. … Colonna M. (Blood 2007) 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 64
- Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PMID: 22939635) Reiner A.P. … Tang H. (Am. J. Hum. Genet. 2012) 3 64
Products for FCRL6 Gene
- R&D Systems Antibodies for FCRL6 (FCRL6/FcRH6)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for FCRL6 (FCRL6/FcRH6)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FCRL6
- Search Origene for MassSpec and Protein Over-expression Lysates for FCRL6
- Origene Custom Protein Services for FCRL6
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCRL6
- Browse OriGene Inhibitory RNA Products For FCRL6
- OriGene qPCR primer pairs for FCRL6
- OriGene CRISPR knockouts for FCRL6
- OriGene ORF clones in human for FCRL6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FCRL6
- GenScript: Next-day shipping cDNA ORF clone for FCRL6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FCRL6
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- GenScript Custom overexpressing Cell Line Services for FCRL6
- GenScript: Design CRISPR guide RNA sequences for FCRL6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Sino Biological Human cDNA Clone for FCRL6
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FCRL6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for FCRL6
- ViGene Biosciences adenoviral particle packaged cDNA for FCRL6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FCRL6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FCRL6 gene
- Search ViGene Biosciences for FCRL6
- Horizon Cell Lines for FCRL6
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCRL6
- VectorBuilder custom plasmid, inducible vectors for FCRL6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCRL6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCRL6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer