FCRL6 Gene
protein-coding GIFtS: 46
GCID: GC01P159771
|
|
Fc receptor-like 6
| |
Aliases
for FCRL6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fc Receptor-Like 61 2 | | Fc Receptor-Like Protein 62 | | FcRH61 2 3 | | Fc Receptor-Like Protein 72 | | IFGP61 2 3 | | IgSF Type I Transmembrane Receptor2 | | Fc Receptor Homolog 62 3 | | Leukocyte Receptor2 | | FcR-Like Protein 62 3 | | FCRH63 | | FLJ160561 | | FcRL63 |
Export aliases for FCRL6 gene to outside databasesPrevious GC identifers: GC01P156584 GC01P158036 GC01P131128 |
Summaries
for FCRL6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FCRL6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCRL6 gene promoter:
LHX3b/Lhx3b Pbx1a FOXF2 GATA-3 POU3F2 GATA-1 GATA-2 LHX3a/Lhx3a Cart-1 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCRL6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRL6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.2 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q23.2FCRL6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P159771: view genomic region
(about GC identifiers)
Start:
|
159,770,301 bp from pter |
End:
|
159,786,047 bp from pter |
Size:
|
15,747 bases |
Orientation:
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plus strand |
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Proteins
for FCRL6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCRL6_HUMAN, Q6DN72 (See
protein sequence)Recommended Name: Fc receptor-like protein 6 precursor Size: 434 amino acids; 47748 Da
Subunit: Interacts with PTPN11
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A1KXW6 A2A4D6 Q6DN73 Q6XRC3 Q6ZNI1Alternative splicing: 4 isoforms: Q6DN72-1 Q6DN72-2 Q6DN72-3 Q6DN72-4 Explore the universe of human proteins at neXtProt for FCRL6: NX_Q6DN72
Post-translational modifications:
Phosphorylated on Tyr residue, inducing association with PTPN111
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6DN72
FCRL6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004310.2
ENSEMBL proteins: ENSP00000440712 ENSP00000320625 ENSP00000340949 ENSP00000376068 ENSP00000357086
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FCRL6 for ontologies About GeneDecksing
FCRL6 Antibody Products:
Assay Products for FCRL6: |
Protein
Domains /
Families
for FCRL6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCRL6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6DN72ProtoNet protein and cluster: Q6DN72 1 Blocks protein family: IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: FCRL6_HUMAN, Q6DN72Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif(ITIM). The phosphorylated ITIM motif is involved in PTPN11 bindingSimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains |
Function
for FCRL6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FCRL6 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FCRL6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019903 | protein phosphatase binding |
IEA | -- |
FCRL6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FCRL6:
|
Pathways & Interactions
for FCRL6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCRL6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/15 Interacting proteins for FCRL6 (ENSP000003570864) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
|
Drugs & Compounds
for FCRL6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FCRL6
Search CenterWatch for drugs/clinical trials and news about FCRL6
|
Transcripts
for FCRL6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCRL6 gene: NM_001004310.2 Unigene Cluster for FCRL6: Fc receptor-like 6 Hs.196955 [show with all ESTs]Unigene Representative Sequence: AK1312017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000540741(uc010pix.1) ENST00000536257 ENST00000321935(uc001fuc.2 uc009wsz.1 uc001fud.4 uc009wta.3)
ENST00000541729 ENST00000339348 ENST00000392235 ENST00000368106
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FCRL6 (NM_001004310) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCRL6 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FCRL6 |
Additional cDNA sequence: AK131201.1 AK301270.1 AY212514.1 AY513661.1 AY654627.1 AY654628.1 3 DOTS entries: DT.65287761 DT.121432953 DT.75160742 4 AceView cDNA sequences: AK131201 AY212514 AI631310 AI677739
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FCRL6 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FCRL6
|
Expression
for FCRL6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCRL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCGCATAA
About this image
See FCRL6 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.196955
UniProtKB/Swiss-Prot: FCRL6_HUMAN, Q6DN72Tissue specificity: Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells.Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector andeffector-memory CD8+ T-cells but also populations of CD4+ T-cells
SABiosciences Custom PCR Arrays for FCRL6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCRL6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCRL6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCRL6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCRL6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL6 |
Orthologs
for FCRL6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FCRL6 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
-- |
22(a) |
1 → many |
25(1707231-1709870) |
ENSEMBL Gene Tree for FCRL6 (if available)
TreeFam Gene Tree for FCRL6 (if available) |
Paralogs
for FCRL6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCRL6 gene
- FCGR2B2 FCGR1B2 FCGR3B2 FCRL22 FCRLB2 FCRL12 FCRL42 FCRL52
- FCRLA2 FCGR1A2 FCGR2A2 FCGR3A2 FCRL32 FCER1A2
3 SIMAP similar genes for FCRL6 using alignment to 2 protein entries: FCRL6_HUMAN (see all proteins):FCRLA DKFZp686L20250 FCGR1A
FCRL6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FCRL6
PGOHUM00000244306
|
Genomic Variants
for FCRL6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCRL6 (159770301 - 159786047 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FCRL6: --
Human Gene Mutation Database (HGMD): FCRL6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCRL6 |
|
Disorders
/ Diseases
for FCRL6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCRL6 for disorders About GeneDecksing
OMIM gene information: 613562
OMIM disorders: --
16  diseases for FCRL6: About MalaCardsguillain-barre syndrome pre-eclampsia severe combined immunodeficiency combined immunodeficiency
viral pneumonia chronic lymphocytic leukemia lymphocytic leukemia osteomyelitis
spondyloarthropathy eclampsia pneumonia vasculitis
asthma liver disease immunodeficiency leukemia
3 Novoseek disease relationships for FCRL6 gene About this table
Export disorders for FCRL6 gene to outside databases
|
Publications
for FCRL6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCRL6 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with FCRL6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. (PubMed id 17213291)1, 2 Wilson T.J....Colonna M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cutting edge: FcR-like 6 is an MHC class II receptor. (PubMed id 20519654)1 Schreeder D.M....Davis R.S. (2010)
- FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia. (PubMed id 18991291)1 Schreeder D.M....Davis R.S. (2008)
- The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. (PubMed id 17273841)1 Taylor A.I....Calvert R.A. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Recognition of classical and heavy chain forms of HLA-B27 by leukocyte receptors. (PubMed id 15011960)9 Allen R.L. and Trowsdale J. (2004)
- The interaction of Fc alpha RI with IgA and its implications for ligand binding by immunoreceptors of the leukocyte receptor cluster. (PubMed id 11160224)9 Wines B.D....Hogarth P.M. (2001)
- Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)9 Wende H.... Ziegler A. (2000)
|
External Searches for FCRL6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCRL6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCRL6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCRL6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCRL6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCRL6 gene:
Search GeneIP for patents involving FCRL6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCRL6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | FCRL6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL6 |
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