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Aliases for FCRL6 Gene

Aliases for FCRL6 Gene

  • Fc Receptor-Like 6 2 3
  • Fc Receptor Homolog 6 3 4
  • FcR-Like Protein 6 3 4
  • FcRH6 3 4
  • IFGP6 3 4
  • IgSF Type I Transmembrane Receptor 3
  • Fc Receptor-Like Protein 6 3
  • Fc Receptor-Like Protein 7 3
  • Leukocyte Receptor 3
  • FcRL6 4

External Ids for FCRL6 Gene

Previous GeneCards Identifiers for FCRL6 Gene

  • GC01P156584
  • GC01P158036
  • GC01P131128

Summaries for FCRL6 Gene

GeneCards Summary for FCRL6 Gene

FCRL6 (Fc Receptor-Like 6) is a Protein Coding gene. Diseases associated with FCRL6 include viral pneumonia and chronic lymphocytic leukemia. GO annotations related to this gene include protein phosphatase binding. An important paralog of this gene is FCRL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL6 Gene

Genomics for FCRL6 Gene

Regulatory Elements for FCRL6 Gene

Genomic Location for FCRL6 Gene

159,800,492 bp from pter
159,816,257 bp from pter
15,766 bases
Plus strand

Genomic View for FCRL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCRL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL6 Gene

Proteins for FCRL6 Gene

  • Protein details for FCRL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 6
    Protein Accession:
    Secondary Accessions:
    • A1KXW6
    • A2A4D6
    • Q6DN73
    • Q6XRC3
    • Q6ZNI1

    Protein attributes for FCRL6 Gene

    434 amino acids
    Molecular mass:
    47748 Da
    Quaternary structure:
    • Interacts with PTPN11.

    Alternative splice isoforms for FCRL6 Gene


neXtProt entry for FCRL6 Gene

Proteomics data for FCRL6 Gene at MOPED

Post-translational modifications for FCRL6 Gene

  • Phosphorylated on Tyr residue, inducing association with PTPN11.
  • Glycosylation at Asn65 and Asn273
  • Modification sites at PhosphoSitePlus

Other Protein References for FCRL6 Gene

No data available for DME Specific Peptides for FCRL6 Gene

Domains for FCRL6 Gene

Gene Families for FCRL6 Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCRL6 Gene

Suggested Antigen Peptide Sequences for FCRL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6DN72
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCRL6: view

Function for FCRL6 Gene

Gene Ontology (GO) - Molecular Function for FCRL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019903 protein phosphatase binding --
genes like me logo Genes that share ontologies with FCRL6: view

Phenotypes for FCRL6 Gene

genes like me logo Genes that share phenotypes with FCRL6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FCRL6 Gene

Localization for FCRL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FCRL6 Gene COMPARTMENTS Subcellular localization image for FCRL6 gene
Compartment Confidence
plasma membrane 5
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FCRL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 17213291
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCRL6: view

Pathways for FCRL6 Gene

SuperPathways for FCRL6 Gene

No Data Available

Interacting Proteins for FCRL6 Gene

Gene Ontology (GO) - Biological Process for FCRL6 Gene


No data available for Pathways by source for FCRL6 Gene

Transcripts for FCRL6 Gene

mRNA/cDNA for FCRL6 Gene

(4) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(8) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCRL6 Gene

Fc receptor-like 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCRL6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -
SP3: - -

Relevant External Links for FCRL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL6 Gene

mRNA expression in normal human tissues for FCRL6 Gene

mRNA differential expression in normal tissues according to GTEx for FCRL6 Gene

This gene is overexpressed in Whole Blood (28.5) and Spleen (6.5).

Protein differential expression in normal tissues for FCRL6 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FCRL6 Gene

SOURCE GeneReport for Unigene cluster for FCRL6 Gene Hs.196955

mRNA Expression by UniProt/SwissProt for FCRL6 Gene

Tissue specificity: Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells.
genes like me logo Genes that share expressions with FCRL6: view

Expression partners for FCRL6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FCRL6 Gene

Orthologs for FCRL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FCRL6 35
  • 76.65 (n)
  • 63.28 (a)
FCRL6 36
  • 63 (a)
(Mus musculus)
Mammalia Fcrl6 35
  • 63.53 (n)
  • 46.27 (a)
Fcrl6 16
Fcrl6 36
  • 45 (a)
(Pan troglodytes)
Mammalia FCRL6 35
  • 95.79 (n)
  • 93.94 (a)
FCRL6 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fcrl6 35
  • 66.04 (n)
  • 47.2 (a)
(Canis familiaris)
Mammalia FCRL6 36
  • 53 (a)
(Monodelphis domestica)
Mammalia FCRL6 36
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
-- 36
  • 16 (a)
-- 36
  • 32 (a)
(Gallus gallus)
Aves FCRL2 36
  • 18 (a)
Species with no ortholog for FCRL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL6 Gene

Gene Tree for FCRL6 (if available)
Gene Tree for FCRL6 (if available)

Paralogs for FCRL6 Gene

Selected SIMAP similar genes for FCRL6 Gene using alignment to 2 proteins: Pseudogenes for FCRL6 Gene

genes like me logo Genes that share paralogs with FCRL6: view

Variants for FCRL6 Gene

Sequence variations from dbSNP and Humsavar for FCRL6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3935782 -- 159,800,894(+) GGTGG(C/T)GCATG upstream-variant-2KB, intron-variant
rs4301626 -- 159,815,580(+) CCCAG(C/T)GAGGT synonymous-codon, reference, stop-lost
rs4411129 -- 159,815,494(+) CCTCT(C/G)TCTTA intron-variant
rs4443889 - 159,815,635(+) CCCTT(A/G)GCGAC reference, missense, utr-variant-3-prime
rs6656168 -- 159,808,782(+) TGGCT(A/G)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL6 Gene

Variant ID Type Subtype PubMed ID
nsv521503 CNV Loss 19592680
esv991387 CNV Insertion 20482838

Relevant External Links for FCRL6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL6 Gene

Disorders for FCRL6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FCRL6 Gene in MalaCards »

(2) Diseases for FCRL6 Gene including...

(3) Novoseek inferred disease relationships for FCRL6 Gene

Disease -log(P) Hits PubMed IDs
inflammation 11.3 5
asthma 0 2
pneumonia 0 1
genes like me logo Genes that share disorders with FCRL6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for FCRL6 Gene

Publications for FCRL6 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. (PMID: 17213291) Wilson T.J. … Colonna M. (Blood 2007) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. (PMID: 17273841) Taylor A.I. … Calvert R.A. (Immunogenetics 2007) 3

Products for FCRL6 Gene

Sources for FCRL6 Gene

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