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Aliases for FCRL6 Gene

Aliases for FCRL6 Gene

  • Fc Receptor Like 6 2 3 5
  • Fc Receptor Homolog 6 3 4
  • FcR-Like Protein 6 3 4
  • FcRH6 3 4
  • IFGP6 3 4
  • IgSF Type I Transmembrane Receptor 3
  • Fc Receptor-Like Protein 6 3
  • Fc Receptor-Like Protein 7 3
  • Fc Receptor-Like 6 2
  • Leukocyte Receptor 3
  • FcRL6 4

External Ids for FCRL6 Gene

Previous GeneCards Identifiers for FCRL6 Gene

  • GC01P156584
  • GC01P158036
  • GC01P131128

Summaries for FCRL6 Gene

GeneCards Summary for FCRL6 Gene

FCRL6 (Fc Receptor Like 6) is a Protein Coding gene. Diseases associated with FCRL6 include Viral Pneumonia. GO annotations related to this gene include protein phosphatase binding. An important paralog of this gene is FCRL3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL6 Gene

Genomics for FCRL6 Gene

Regulatory Elements for FCRL6 Gene

Enhancers for FCRL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G159888 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +90.0 89973 3.0 HDGF ATF1 SIN3A ZNF2 GLIS2 GATA2 ZNF207 ZNF143 FOS DEK ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01G159908 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.6 +117.0 116973 18.5 FEZF1 YBX1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ZNF610 GLIS1 SNHG28 ENSG00000272668 RPSAP18 ENSG00000228606 VSIG8 PIGM SLAMF8 CADM3 TAGLN2 FCRL6
GH01G159868 1.1 ENCODE dbSUPER 10.6 +68.9 68938 1.3 SREBF2 TCF12 CBX5 FOS ETV6 IKZF2 EGR2 SMARCC1 CBFB JUNB ENSG00000272668 SLAMF8 FCRL6 ENSG00000256029
GH01G159751 1.1 Ensembl ENCODE 10.4 -47.9 -47898 3.2 TBP RAD21 YY1 CBX5 SCRT2 RCOR1 SMARCC1 USF2 CEBPB NR2F2 CRP FCRL6 DUSP23 ENSG00000212161 AIM2 RPL27P2
GH01G159778 1 ENCODE 10.4 -20.1 -20131 3.3 HDGF PKNOX1 ATF1 CREB3L1 SIN3A YY1 GATA2 ZNF143 FOS KLF13 FCRL6 DUSP23 LOC101928264 RPL27P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCRL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for FCRL6 Gene

159,800,511 bp from pter
159,816,257 bp from pter
15,747 bases
Plus strand

Genomic View for FCRL6 Gene

Genes around FCRL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL6 Gene

Proteins for FCRL6 Gene

  • Protein details for FCRL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 6
    Protein Accession:
    Secondary Accessions:
    • A1KXW6
    • A2A4D6
    • Q6DN73
    • Q6XRC3
    • Q6ZNI1

    Protein attributes for FCRL6 Gene

    434 amino acids
    Molecular mass:
    47748 Da
    Quaternary structure:
    • Interacts with PTPN11.

    Alternative splice isoforms for FCRL6 Gene


neXtProt entry for FCRL6 Gene

Post-translational modifications for FCRL6 Gene

  • Phosphorylated on Tyr residue, inducing association with PTPN11.
  • Glycosylation at Asn65 and isoforms=2, 3, 4273
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCRL6 Gene

Domains & Families for FCRL6 Gene

Gene Families for FCRL6 Gene

Protein Domains for FCRL6 Gene

Suggested Antigen Peptide Sequences for FCRL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
genes like me logo Genes that share domains with FCRL6: view

Function for FCRL6 Gene

genes like me logo Genes that share phenotypes with FCRL6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL6 Gene

Localization for FCRL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL6 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FCRL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 17213291
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCRL6: view

Pathways & Interactions for FCRL6 Gene

SuperPathways for FCRL6 Gene

No Data Available

Interacting Proteins for FCRL6 Gene

Selected Interacting proteins: Q6DN72-FCRL6_HUMAN for FCRL6 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FCRL6 Gene


No data available for Pathways by source and SIGNOR curated interactions for FCRL6 Gene

Drugs & Compounds for FCRL6 Gene

No Compound Related Data Available

Transcripts for FCRL6 Gene

mRNA/cDNA for FCRL6 Gene

(10) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCRL6 Gene

Fc receptor-like 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -
SP3: - -

Relevant External Links for FCRL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL6 Gene

mRNA differential expression in normal tissues according to GTEx for FCRL6 Gene

This gene is overexpressed in Whole Blood (x28.5) and Spleen (x6.5).

Protein differential expression in normal tissues from HIPED for FCRL6 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL6 Gene

Protein tissue co-expression partners for FCRL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCRL6 Gene:


SOURCE GeneReport for Unigene cluster for FCRL6 Gene:


mRNA Expression by UniProt/SwissProt for FCRL6 Gene:

Tissue specificity: Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells.

Evidence on tissue expression from TISSUES for FCRL6 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with FCRL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL6 Gene

Orthologs for FCRL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCRL6 34 35
  • 95.79 (n)
(Bos Taurus)
Mammalia FCRL6 34 35
  • 76.65 (n)
(Rattus norvegicus)
Mammalia Fcrl6 34
  • 66.04 (n)
(Mus musculus)
Mammalia Fcrl6 34 16 35
  • 63.53 (n)
(Canis familiaris)
Mammalia FCRL6 35
  • 53 (a)
(Monodelphis domestica)
Mammalia FCRL6 35
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
-- 35
  • 25 (a)
-- 35
  • 16 (a)
(Gallus gallus)
Aves FCRL2 35
  • 18 (a)
Species where no ortholog for FCRL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL6 Gene

Gene Tree for FCRL6 (if available)
Gene Tree for FCRL6 (if available)

Paralogs for FCRL6 Gene

(4) SIMAP similar genes for FCRL6 Gene using alignment to 2 proteins: Pseudogenes for FCRL6 Gene

genes like me logo Genes that share paralogs with FCRL6: view

Variants for FCRL6 Gene

Sequence variations from dbSNP and Humsavar for FCRL6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000197082 -- 159,813,977(+) TTTTA(C/T)AGAAA intron-variant
rs1000226973 -- 159,800,697(+) AAAAA(A/T)GCCTG intron-variant, upstream-variant-2KB
rs1000436174 -- 159,803,650(+) AGGAA(C/T)AGCCC intron-variant, nc-transcript-variant
rs1000440258 -- 159,803,334(+) TTTTT(A/G)TTTAA intron-variant, nc-transcript-variant
rs1000564714 -- 159,814,933(+) CTGGG(C/T)CTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL6 Gene

Variant ID Type Subtype PubMed ID
esv991387 CNV insertion 20482838
nsv1005195 CNV gain 25217958
nsv521503 CNV loss 19592680

Variation tolerance for FCRL6 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCRL6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL6 Gene

Disorders for FCRL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCRL6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
viral pneumonia
  • pneumonia, viral
- elite association - COSMIC cancer census association via MalaCards
Search FCRL6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCRL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FCRL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCRL6 Gene

Publications for FCRL6 Gene

  1. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. (PMID: 17213291) Wilson T.J. … Colonna M. (Blood 2007) 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 64
  5. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PMID: 22939635) Reiner A.P. … Tang H. (Am. J. Hum. Genet. 2012) 3 64

Products for FCRL6 Gene

Sources for FCRL6 Gene

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