Aliases for FCRL5 Gene
Aliases for FCRL5 Gene
External Ids for FCRL5 Gene
- HGNC: 18508
- Entrez Gene: 83416
- Ensembl: ENSG00000143297
- OMIM: 605877
- UniProtKB: Q96RD9
Previous GeneCards Identifiers for FCRL5 Gene
- GC01M154297
- GC01M155752
- GC01M128841
Summaries for FCRL5 Gene
-
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
GeneCards Summary for FCRL5 Gene
FCRL5 (Fc Receptor Like 5) is a Protein Coding gene. Diseases associated with FCRL5 include Hairy Cell Leukemia and Burkitt Lymphoma. An important paralog of this gene is FCRL3.
UniProtKB/Swiss-Prot for FCRL5 Gene
-
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL5 Gene
Genomics for FCRL5 Gene
Regulatory Elements for FCRL5 Gene
Enhancers for FCRL5 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G157562 | 0.8 | FANTOM5 | 40 | -10.2 | -10155 | 0.3 | PKNOX1 TBL1XR1 ARID3A ELK1 ZSCAN29 RELB IKZF2 CHD2 MAZ MTA2 | FCRL5 FCRL4 |
| GH01G157566 | 0.7 | ENCODE | 36.2 | -14.4 | -14436 | 1.7 | MAZ MTA2 MAFG TBX21 EP300 RELA PBX2 IKZF1 NFE2 RELB | FCRL5 ENSG00000227217 FCRL3 FCRL4 |
| GH01G157552 | 0.7 | ENCODE | 35.4 | 0.0 | -46 | 1.0 | PKNOX1 MTA2 CBFB NR2F1 GATAD2B DPF2 TBX21 RELA POLR2A IKZF1 | FCRL5 FCRL4 |
| GH01G157519 | 0.7 | ENCODE | 31 | +32.8 | 32784 | 1.3 | CTCF RB1 ZNF133 ZNF384 ZNF2 ZIC2 RAD21 FOXK2 SMC3 ZNF362 | FCRL5 FCRL1 PIR33564 |
| GH01G157510 | 1.1 | ENCODE dbSUPER | 17.2 | +40.5 | 40500 | 2.5 | HDGF PKNOX1 TBL1XR1 BMI1 ZBTB40 RELB ETV6 IKZF2 CREM EGR2 | FCRL5 FCRL1 PIR33564 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCRL5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCRL5 gene promoter:
Regulatory Element Products
Genomic Location for FCRL5 Gene
- Chromosome:
- 1
- Start:
- 157,513,377 bp from pter
- End:
- 157,552,520 bp from pter
- Size:
- 39,144 bases
- Orientation:
- Minus strand
Genomic View for FCRL5 Gene
Genes around FCRL5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.1 by Ensembl
- 1q23.1 by Entrez Gene
- 1q23.1 by HGNC
FCRL5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCRL5 Gene
Proteins for FCRL5 Gene
-
Protein details for FCRL5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RD9-FCRL5_HUMAN
- Recommended name:
- Fc receptor-like protein 5
- Protein Accession:
- Q96RD9
- A0N0M2
- B7WNT9
- B7WP94
- Q495Q2
- Q495Q4
- Q5VYK9
- Q6UY46
Protein attributes for FCRL5 Gene
- Size:
- 977 amino acids
- Molecular mass:
- 106437 Da
- Quaternary structure:
- No Data Available
Protein Expression for FCRL5 Gene
Post-translational modifications for FCRL5 Gene
Other Protein References for FCRL5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FCRL5 (FCRL5/FcRH5)
-
Custom Antibody ServicesOriGene Antibodies for FCRL5
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-
Abcam antibodies for FCRL5
- Invitrogen Antibodies for FCRL5
- antibodies-online Antibodies for FCRL5: See all 4
- GeneTex FCRL5 antibody for FCRL5
Protein Products
- R&D Systems Proteins and Enzymes for FCRL5 (FCRL5/FcRH5)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FCRL5
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-
Abcam proteins for FCRL5
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for FCRL5 (FCRL5/FcRH5)
No data available for DME Specific Peptides for FCRL5 Gene
Domains & Families for FCRL5 Gene
Gene Families for FCRL5 Gene
Protein Domains for FCRL5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCRL5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96RD9UniProtKB/Swiss-Prot:
FCRL5_HUMAN :- Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).
- Domain:
-
- Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).
Function for FCRL5 Gene
Molecular function for FCRL5 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
Phenotypes for FCRL5 Gene
- GenomeRNAi human phenotypes for FCRL5:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
Animal Model Products
-
Taconic Biosciences Mouse Models for FCRL5
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRL5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL5 gene
- Search ViGene Biosciences for FCRL5
CRISPR Products
-
OriGene CRISPR knockouts for FCRL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRL5
- GenScript: Design CRISPR guide RNA sequences for FCRL5
miRNA Products
- Search ViGene Biosciences for FCRL5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCRL5
- Browse OriGene Inhibitory RNA Products For FCRL5
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL5 gene
Clone Products
- Sino Biological Human cDNA Clone for FCRL5
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Cell Line Products
-
Horizon Cell Lines for FCRL5
-
ViGene Biosciences adenoviral particle packaged cDNA for FCRL5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRL5 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL5 Gene
Localization for FCRL5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCRL5 Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043235 | receptor complex | IDA | 23382219 |
Pathways & Interactions for FCRL5 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for FCRL5 Gene
Transcripts for FCRL5 Gene
mRNA/cDNA for FCRL5 Gene
- (6) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (81) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FCRL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRL5
- GenScript: Design CRISPR guide RNA sequences for FCRL5
miRNA Products
- Search ViGene Biosciences for FCRL5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCRL5
- Browse OriGene Inhibitory RNA Products For FCRL5
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL5 gene
Clone Products
- Sino Biological Human cDNA Clone for FCRL5
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Expression for FCRL5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for FCRL5 Gene
This gene is overexpressed in Spleen (x12.2) and Small Intestine - Terminal Ileum (x4.3).
This gene is overexpressed in Plasma (67.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FCRL5 Gene:
FCRL5SOURCE GeneReport for Unigene cluster for FCRL5 Gene:
Hs.415950mRNA Expression by UniProt/SwissProt for FCRL5 Gene:
Q96RD9-FCRL5_HUMAN
Tissue specificity:
Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).
Evidence on tissue expression from TISSUES for FCRL5 Gene
- Lymph node(4.3)
Primer Products
-
OriGene qPCR primer pairs for FCRL5
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL5 Gene
Orthologs for FCRL5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCRL5 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCRL5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCRL5 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcrl5 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcrl3 34 |
|
||
| chicken (Gallus gallus) |
Aves | FCRL2 35 |
|
OneToMany |
- Species where no ortholog for FCRL5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCRL5 Gene
Paralogs for FCRL5 Gene
(10) SIMAP similar genes for FCRL5 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for FCRL5 Gene
Variants for FCRL5 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035514 | A breast cancer sample | ||||
| rs1000047883 | -- | 157,531,420(+) | TCTCA(A/G)TAAAA | intron-variant | |
| rs1000436157 | -- | 157,548,355(+) | ATACC(A/C)TTCAG | intron-variant | |
| rs1000577338 | -- | 157,548,094(+) | GCCAT(G/T)GAGTT | intron-variant | |
| rs1000620773 | -- | 157,553,134(+) | ATACT(A/G)GTCAA | upstream-variant-2KB |
Residual Variation Intolerance Score:
90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.09;
75.38% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCRL5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCRL5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL5 Gene
Disorders for FCRL5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hairy cell leukemia |
|
|
| burkitt lymphoma |
|
|
Search FCRL5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FCRL5_HUMAN- Note=A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32). {ECO:0000269 PubMed:11290337}.
Relevant External Links for FCRL5
No data available for Genatlas for FCRL5 Gene
Publications for FCRL5 Gene
- IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells. (PMID: 11929751) Miller I. … Dalla-Favera R. (Blood 2002) 3 4 22 64
- IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PMID: 11290337) Hatzivassiliou G. … Dalla-Favera R. (Immunity 2001) 2 3 4 64
- Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. (PMID: 20626413) Simmonds M.J. … Gough S.C. (Clin. Endocrinol. (Oxf) 2010) 3 46 64
- A single-nucleotide polymorphism marker within the FCRL5 gene and HLA-B27 positive Han Chinese ankylosing spondylitis patients. (PMID: 19775371) Tang X. … Xu J. (Tissue Antigens 2009) 3 46 64
- Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera. (PMID: 16681430) Ise T. … Nagata S. (Clin. Chem. Lab. Med. 2006) 3 22 64
Products for FCRL5 Gene
- R&D Systems Antibodies for FCRL5 (FCRL5/FcRH5)
- R&D Systems Proteins and Enzymes for FCRL5 (FCRL5/FcRH5)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for FCRL5 (FCRL5/FcRH5)
- R&D Systems cDNA Clones for FCRL5 (FCRL5/FcRH5)
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- Custom Antibody ServicesOriGene Antibodies for FCRL5
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- Novus Biologicals Antibodies for FCRL5
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- Abcam proteins for FCRL5
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- Search knockout validated antibodies
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- Taconic Biosciences Mouse Models for FCRL5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for FCRL5 gene
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- Horizon Cell Lines for FCRL5
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCRL5
- VectorBuilder custom plasmid, inducible vectors for FCRL5
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCRL5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer