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Aliases for FCRL5 Gene

Aliases for FCRL5 Gene

  • Fc Receptor-Like 5 2 3
  • IRTA2 3 4 6
  • Immune Receptor Translocation-Associated Protein 2 3 4
  • Fc Receptor Homolog 5 3 4
  • FcR-Like Protein 5 3 4
  • BXMAS1 3 4
  • FCRH5 3 4
  • Immunoglobulin Superfamily Receptor Translocation Associated 2 (IRTA2) 3
  • Fc Receptor-Like Protein 5 3
  • CD307e Antigen 4
  • CD307e 3
  • PRO820 3
  • CD307 3
  • FcRL5 4

External Ids for FCRL5 Gene

Previous GeneCards Identifiers for FCRL5 Gene

  • GC01M154297
  • GC01M155752
  • GC01M128841

Summaries for FCRL5 Gene

Entrez Gene Summary for FCRL5 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for FCRL5 Gene

FCRL5 (Fc Receptor-Like 5) is a Protein Coding gene. Diseases associated with FCRL5 include chronic lymphocytic leukemia. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCRL5 Gene

  • May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

Gene Wiki entry for FCRL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL5 Gene

Genomics for FCRL5 Gene

Regulatory Elements for FCRL5 Gene

Genomic Location for FCRL5 Gene

Start:
157,513,377 bp from pter
End:
157,552,520 bp from pter
Size:
39,144 bases
Orientation:
Minus strand

Genomic View for FCRL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCRL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL5 Gene

Proteins for FCRL5 Gene

  • Protein details for FCRL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD9-FCRL5_HUMAN
    Recommended name:
    Fc receptor-like protein 5
    Protein Accession:
    Q96RD9
    Secondary Accessions:
    • A0N0M2
    • B7WNT9
    • B7WP94
    • Q495Q2
    • Q495Q4
    • Q5VYK9
    • Q6UY46

    Protein attributes for FCRL5 Gene

    Size:
    977 amino acids
    Molecular mass:
    106437 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCRL5 Gene

Proteomics data for FCRL5 Gene at MOPED

Post-translational modifications for FCRL5 Gene

  • Glycosylation at Asn383
  • Modification sites at PhosphoSitePlus

Other Protein References for FCRL5 Gene

Antibody Products

No data available for DME Specific Peptides for FCRL5 Gene

Domains for FCRL5 Gene

Gene Families for FCRL5 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCRL5 Gene

Suggested Antigen Peptide Sequences for FCRL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RD9

UniProtKB/Swiss-Prot:

FCRL5_HUMAN :
  • Q96RD9
Domain:
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).
  • Contains 8 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCRL5: view

Function for FCRL5 Gene

Molecular function for FCRL5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

Gene Ontology (GO) - Molecular Function for FCRL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FCRL5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCRL5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FCRL5 Gene

Localization for FCRL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL5 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCRL5 Gene COMPARTMENTS Subcellular localization image for FCRL5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FCRL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with FCRL5: view

Pathways for FCRL5 Gene

SuperPathways for FCRL5 Gene

No Data Available

Interacting Proteins for FCRL5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354691%0d%0a9606.ENSP00000364650%0d%0a9606.ENSP00000364467%0d%0a
Selected Interacting proteins: ENSP00000354691 for FCRL5 Gene via STRING

Gene Ontology (GO) - Biological Process for FCRL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050859 negative regulation of B cell receptor signaling pathway IEA --
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol IEA --
genes like me logo Genes that share ontologies with FCRL5: view

No data available for Pathways by source for FCRL5 Gene

Transcripts for FCRL5 Gene

Unigene Clusters for FCRL5 Gene

Fc receptor-like 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCRL5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7:
SP8:
SP9: - -

Relevant External Links for FCRL5 Gene

GeneLoc Exon Structure for
FCRL5
ECgene alternative splicing isoforms for
FCRL5

Expression for FCRL5 Gene

mRNA expression in normal human tissues for FCRL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL5 Gene

This gene is overexpressed in Spleen (12.2) and Small Intestine - Terminal Ileum (4.3).

Protein differential expression in normal tissues for FCRL5 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCRL5 Gene

SOURCE GeneReport for Unigene cluster for FCRL5 Gene Hs.415950

mRNA Expression by UniProt/SwissProt for FCRL5 Gene

Q96RD9-FCRL5_HUMAN
Tissue specificity: Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).
genes like me logo Genes that share expressions with FCRL5: view

Expression partners for FCRL5 Gene

In Situ Assay Products

Orthologs for FCRL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCRL5 35
  • 66.81 (n)
  • 53.89 (a)
FCRL5 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCRL5 35
  • 72.58 (n)
  • 58.73 (a)
FCRL5 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcrl5 35
  • 62.82 (n)
  • 44.66 (a)
Fcrl5 36
  • 45 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FCRL5 35
  • 98.5 (n)
  • 97.34 (a)
FCRL5 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcrl3 35
  • 60.48 (n)
  • 44.98 (a)
chicken
(Gallus gallus)
Aves FCRL2 36
  • 30 (a)
OneToMany
Species with no ortholog for FCRL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL5 Gene

ENSEMBL:
Gene Tree for FCRL5 (if available)
TreeFam:
Gene Tree for FCRL5 (if available)

Paralogs for FCRL5 Gene

Selected SIMAP similar genes for FCRL5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FCRL5 Gene

genes like me logo Genes that share paralogs with FCRL5: view

Variants for FCRL5 Gene

Sequence variations from dbSNP and Humsavar for FCRL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs849835 -- 157,552,924(+) AAATA(A/G)GATAT upstream-variant-2KB
rs849836 -- 157,550,701(-) GTGAA(C/T)ATTAA intron-variant
rs914724 -- 157,538,194(+) TTGAT(A/G)ACTCC intron-variant
rs914725 -- 157,538,195(+) TGATG(A/T)CTCCC intron-variant
rs1002967 -- 157,515,930(+) CCTTG(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL5 Gene

Variant ID Type Subtype PubMed ID
nsv831681 CNV Gain+Loss 17160897
esv275399 CNV Loss 21479260
esv2718507 CNV Deletion 23290073
nsv3143 CNV Insertion 18451855

Relevant External Links for FCRL5 Gene

HapMap Linkage Disequilibrium report
FCRL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL5 Gene

Disorders for FCRL5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FCRL5 Gene in MalaCards »

(1) Diseases for FCRL5 Gene including...

UniProtKB/Swiss-Prot

FCRL5_HUMAN
  • Note=A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32). {ECO:0000269 PubMed:11290337}.

(2) Novoseek inferred disease relationships for FCRL5 Gene

Disease -log(P) Hits PubMed IDs
leukemia hairy cell 71.9 1
lymphoma 27.1 4

Relevant External Links for FCRL5

Genetic Association Database (GAD)
FCRL5
Human Genome Epidemiology (HuGE) Navigator
FCRL5
genes like me logo Genes that share disorders with FCRL5: view

No data available for OMIM , University of Copenhagen DISEASES and Genatlas for FCRL5 Gene

Publications for FCRL5 Gene

  1. IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells. (PMID: 11929751) Miller I. … Dalla-Favera R. (Blood 2002) 3 4 23
  2. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PMID: 11290337) Hatzivassiliou G. … Dalla-Favera R. (Immunity 2001) 2 3 4
  3. BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells. (PMID: 11453668) Nakayama Y. … Bothwell A.L.M. (Biochem. Biophys. Res. Commun. 2001) 3 4
  4. Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis R.S. … Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  5. Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies. (PMID: 15671532) Ise T. … Nagata S. (Clin. Cancer Res. 2005) 3 23

Products for FCRL5 Gene

Sources for FCRL5 Gene

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