Aliases for FCRL4 Gene
Aliases for FCRL4 Gene
External Ids for FCRL4 Gene
- HGNC: 18507
- Entrez Gene: 83417
- Ensembl: ENSG00000163518
- OMIM: 605876
- UniProtKB: Q96PJ5
Previous GeneCards Identifiers for FCRL4 Gene
- GC01M154357
- GC01M155811
- GC01M128901
Summaries for FCRL4 Gene
-
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
GeneCards Summary for FCRL4 Gene
FCRL4 (Fc Receptor Like 4) is a Protein Coding gene. Diseases associated with FCRL4 include Hodgkin Lymphoma and Multiple Myeloma. An important paralog of this gene is FCRL3.
UniProtKB/Swiss-Prot for FCRL4 Gene
-
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL4 Gene
Genomics for FCRL4 Gene
Regulatory Elements for FCRL4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G157595 | 0.8 | ENCODE | 0.7 | +2.5 | 2545 | 0.1 | TBL1XR1 WRNIP1 BMI1 CBX5 EED ETV6 RELB IKZF2 CREM CHD2 | FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4 |
| GH01G157562 | 0.8 | FANTOM5 | 0.3 | +35.4 | 35406 | 0.3 | PKNOX1 TBL1XR1 ARID3A ELK1 ZSCAN29 RELB IKZF2 CHD2 MAZ MTA2 | FCRL5 FCRL4 |
| GH01G157566 | 0.7 | ENCODE | 0.3 | +31.1 | 31125 | 1.7 | MAZ MTA2 MAFG TBX21 EP300 RELA PBX2 IKZF1 NFE2 RELB | FCRL5 ENSG00000227217 FCRL3 FCRL4 |
| GH01G157552 | 0.7 | ENCODE | 0.2 | +45.5 | 45515 | 1.0 | PKNOX1 MTA2 CBFB NR2F1 GATAD2B DPF2 TBX21 RELA POLR2A IKZF1 | FCRL5 FCRL4 |
- Transcription factor binding sites by QIAGEN in the FCRL4 gene promoter:
Regulatory Element Products
Genomic Location for FCRL4 Gene
- Chromosome:
- 1
- Start:
- 157,573,749 bp from pter
- End:
- 157,598,080 bp from pter
- Size:
- 24,332 bases
- Orientation:
- Minus strand
Genomic View for FCRL4 Gene
- Cytogenetic band:
-
- 1q23.1 by Ensembl
- 1q23.1 by Entrez Gene
- 1q23.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCRL4 Gene
Proteins for FCRL4 Gene
-
Protein details for FCRL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PJ5-FCRL4_HUMAN
- Recommended name:
- Fc receptor-like protein 4
- Protein Accession:
- Q96PJ5
- Q96PJ3
- Q96RE0
Protein attributes for FCRL4 Gene
- Size:
- 515 amino acids
- Molecular mass:
- 57224 Da
- Quaternary structure:
- No Data Available
Protein Expression for FCRL4 Gene
Post-translational modifications for FCRL4 Gene
- Phosphorylated on cytoplasmic tyrosines upon activation.
- Glycosylation at Asn374
- Modification sites at PhosphoSitePlus
Other Protein References for FCRL4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FCRL4 (FCRL4/FcRH4)
-
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-
Abcam antibodies for FCRL4
- Invitrogen Antibodies for FCRL4
- GeneTex FCRL4 antibody for FCRL4
Protein Products
-
OriGene Purified Proteins for FCRL4
- Search Origene for MassSpec and Protein Over-expression Lysates for FCRL4
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- Search GeneTex for Proteins for FCRL4
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for FCRL4 (FCRL4/FcRH4)
No data available for DME Specific Peptides for FCRL4 Gene
Domains & Families for FCRL4 Gene
Gene Families for FCRL4 Gene
Protein Domains for FCRL4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCRL4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCRL4 Gene
Function for FCRL4 Gene
Molecular function for FCRL4 Gene
- UniProtKB/Swiss-Prot Function:
- May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21982860 |
Phenotypes for FCRL4 Gene
- GenomeRNAi human phenotypes for FCRL4:
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for FCRL4 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for FCRL4
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miRNA for FCRL4 Gene
- miRTarBase miRNAs that target FCRL4
-
- hsa-mir-335-5p (MIRT016840)
- hsa-mir-6830-3p (MIRT611799)
- hsa-mir-4659b-3p (MIRT611800)
- hsa-mir-6875-3p (MIRT611801)
- hsa-mir-4659a-3p (MIRT611802)
- hsa-mir-6867-3p (MIRT611803)
- hsa-mir-6749-3p (MIRT611804)
- hsa-mir-6792-3p (MIRT611805)
- hsa-mir-4691-5p (MIRT611806)
- hsa-mir-211-5p (MIRT611807)
- hsa-mir-204-5p (MIRT611808)
- hsa-mir-642a-5p (MIRT611809)
- hsa-mir-4778-3p (MIRT611810)
- hsa-mir-1236-3p (MIRT611811)
- hsa-mir-6515-3p (MIRT611812)
- hsa-mir-6845-3p (MIRT611813)
- hsa-mir-4685-3p (MIRT611814)
- hsa-mir-4287 (MIRT611815)
- hsa-mir-7113-3p (MIRT611816)
- hsa-mir-4469 (MIRT611817)
- hsa-mir-6769b-3p (MIRT611818)
- hsa-mir-4723-3p (MIRT611819)
- hsa-mir-3183 (MIRT611820)
- hsa-mir-2276-5p (MIRT611821)
- hsa-mir-6892-3p (MIRT611822)
- hsa-mir-6832-3p (MIRT616798)
- hsa-mir-627-3p (MIRT626692)
miRNA Products
- Search ViGene Biosciences for FCRL4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCRL4
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for FCRL4
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCRL4 Gene
Localization for FCRL4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCRL4 Gene
- Cell membrane; Single-pass type I membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for FCRL4 Gene
Interacting Proteins for FCRL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FCRL4 Gene
Transcripts for FCRL4 Gene
mRNA/cDNA for FCRL4 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FCRL4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRL4
- GenScript: Design CRISPR guide RNA sequences for FCRL4
miRNA Products
- Search ViGene Biosciences for FCRL4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCRL4
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-
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Clone Products
-
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Flow Cytometry Products
Expression for FCRL4 Gene
mRNA differential expression in normal tissues according to GTEx for FCRL4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL4 Gene
NURSA nuclear receptor signaling pathways regulating expression of FCRL4 Gene:
FCRL4SOURCE GeneReport for Unigene cluster for FCRL4 Gene:
Hs.120260mRNA Expression by UniProt/SwissProt for FCRL4 Gene:
Q96PJ5-FCRL4_HUMANEvidence on tissue expression from TISSUES for FCRL4 Gene
- Lymph node(4.3)
- Spleen(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for FCRL4
-
OriGene qPCR primer pairs for FCRL4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL4 Gene
Orthologs for FCRL4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCRL4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCRL4 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FCRL4 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | FCRL2 35 |
|
OneToMany |
- Species where no ortholog for FCRL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCRL4 Gene
Paralogs for FCRL4 Gene
(4) SIMAP similar genes for FCRL4 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for FCRL4 Gene
Variants for FCRL4 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000125837 | -- | 157,599,491(+) | TGGAT(G/T)AAGAG | upstream-variant-2KB | |
| rs1000463315 | -- | 157,578,446(+) | GTTTG(A/C)AGCCA | intron-variant | |
| rs1000655940 | -- | 157,594,124(+) | TCTAT(A/C)ATAGG | intron-variant | |
| rs1000657728 | -- | 157,594,918(+) | ATTTT(C/T)CAGAT | intron-variant | |
| rs1000743145 | -- | 157,588,698(+) | GAAGT(G/T)ACCAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2661330 | CNV | deletion | 23128226 |
| esv2718507 | CNV | deletion | 23290073 |
| esv3587653 | CNV | loss | 21293372 |
| nsv3154 | CNV | insertion | 18451855 |
Relevant External Links for FCRL4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL4 Gene
Disorders for FCRL4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hodgkin lymphoma |
|
|
| multiple myeloma |
|
|
UniProtKB/Swiss-Prot
FCRL4_HUMAN- Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. {ECO:0000269 PubMed:11290337}.
- Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). {ECO:0000269 PubMed:12619161}.
Relevant External Links for FCRL4
No data available for Genatlas for FCRL4 Gene
Publications for FCRL4 Gene
- Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). (PMID: 12881317) Falini B. … Cattoretti G. (Blood 2003) 3 4 22 64
- IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells. (PMID: 11929751) Miller I. … Dalla-Favera R. (Blood 2002) 3 4 22 64
- Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis R.S. … Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 64
- IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PMID: 11290337) Hatzivassiliou G. … Dalla-Favera R. (Immunity 2001) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
Products for FCRL4 Gene
- R&D Systems Antibodies for FCRL4 (FCRL4/FcRH4)
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- Novus Biologicals Antibodies for FCRL4
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- Horizon Cell Lines for FCRL4
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- VectorBuilder custom plasmid, inducible vectors for FCRL4
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCRL4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




