FCRL4 Gene
protein-coding GIFtS: 50
GCID: GC01M157543
|
|
Fc receptor-like 4
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Aliases
for FCRL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fc Receptor-Like 41 2 | | IFGP Family Protein 22 3 | | IRTA11 2 3 5 | | Fc Receptor-Like Protein 42 | | FCRH41 2 3 | | Immunoglobulin Superfamily Fc Receptor, Gp422 | | CD307d1 2 | | Immunoglobulin Superfamily Receptor Translocation Associated 12 | | IGFP21 2 | | FcRH43 | | Fc Receptor Homolog 42 3 | | FcRL43 | | FcR-Like Protein 42 3 | | IFGP23 | | Immune Receptor Translocation-Associated Protein 12 3 | | CD307d Antigen3 | | HIFGP21 | | |
Export aliases for FCRL4 gene to outside databasesPrevious GC identifers: GC01M154357 GC01M155811 GC01M128901 |
Summaries
for FCRL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FCRL4:
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-likeglycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-typeimmunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptortyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia.Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiplemyeloma. (provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: FCRL4_HUMAN, Q96PJ5Function: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immuneresponse
Gene Wiki entry for FCRL4
|
Genomic Views
for FCRL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCRL4 gene promoter:
NRSF form 1 FOXO4 FOXO1a SEF-1 (1) NRSF form 2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCRL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21FCRL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M157543: view genomic region
(about GC identifiers)
Start:
|
157,543,539 bp from pter |
End:
|
157,567,870 bp from pter |
Size:
|
24,332 bases |
Orientation:
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minus strand |
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Proteins
for FCRL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCRL4_HUMAN, Q96PJ5 (See
protein sequence)Recommended Name: Fc receptor-like protein 4 precursor Size: 515 amino acids; 57224 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q96PJ3 Q96RE0Alternative splicing: 2 isoforms: Q96PJ5-1 Q96PJ5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FCRL4: NX_Q96PJ5
Post-translational modifications:
Phosphorylated on cytoplasmic tyrosines upon activation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PJ5
FCRL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112572.1
ENSEMBL proteins: ENSP00000271532
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FCRL4 for ontologies About GeneDecksing
FCRL4 Antibody Products:
Assay Products for FCRL4: |
Protein
Domains /
Families
for FCRL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCRL4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PJ5ProtoNet protein and cluster: Q96PJ5 1 Blocks protein family: IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: FCRL4_HUMAN, Q96PJ5Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains |
Function
for FCRL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FCRL4_HUMAN, Q96PJ5Function: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immuneresponse
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0005515 | protein binding |
IPI | -- |
FCRL4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FCRL4:
|
Pathways & Interactions
for FCRL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCRL4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FCRL4 (Q96PJ51 ENSP000002715324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FCRL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FCRL4
Search CenterWatch for drugs/clinical trials and news about FCRL4
|
Transcripts
for FCRL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCRL4 gene: NM_031282.2 Unigene Cluster for FCRL4: Fc receptor-like 4 Hs.120260 [show with all ESTs]Unigene Representative Sequence: AF3436613 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000271532(uc001fqw.3 uc010phy.2) ENST00000448509 ENST00000479869
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FCRL4 (NM_031282) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCRL4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCRL4 |
Additional cDNA sequence: AF329490.1 AF329492.1 AF343659.1 AF343660.1 AF343661.1 AF397452.1 BC125173.1 BC125174.1 BC143628.1 2 DOTS entries: DT.95363149 DT.409251 23 AceView cDNA sequences: AF329492 AF329490 AA923455 AA830638 AA832065 AA830107 AA731532 AF343661 BF513503 AA811806 AF343659 AF397452 NM_031282 AF343660 AA904824 CF138171 AA419565 BX282909 CD633096 CD633089 CD633095 CD633093 CD633090
GeneLoc Exon Structure
|
Expression
for FCRL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCRL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATATGCATT
About this image
See FCRL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCRL4
SOURCE GeneReport for Unigene cluster: Hs.120260
UniProtKB/Swiss-Prot: FCRL4_HUMAN, Q96PJ5Tissue specificity: Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes.Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level)
SABiosciences Custom PCR Arrays for FCRL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCRL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FCRL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCRL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCRL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL4 |
Orthologs
for FCRL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FCRL4 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
-- |
27(a) |
1 → many |
25(1707231-1709870) |
ENSEMBL Gene Tree for FCRL4 (if available)
TreeFam Gene Tree for FCRL4 (if available) |
Paralogs
for FCRL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCRL4 gene
- FCGR2B2 FCGR1B2 FCGR3B2 FCRL22 FCRLB2 FCRL12 FCRL52 FCRLA2
- FCGR1A2 FCGR2A2 FCGR3A2 FCRL32 FCER1A2 FCRL62
4 SIMAP similar genes for FCRL4 using alignment to 1 protein entry: FCRL4_HUMAN:FCRL3 FCRL5 FCRL2 FCER1A
FCRL4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FCRL4
PGOHUM00000245022
|
Genomic Variants
for FCRL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCRL4 (157543539 - 157567870 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FCRL4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCRL4 |
|
Disorders
/ Diseases
for FCRL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCRL4 for disorders About GeneDecksing
OMIM gene information: 605876
OMIM disorders: --
UniProtKB/Swiss-Prot: FCRL4_HUMAN, Q96PJ5
Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocationt(1;1)(p36.3; q21.1-2) Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocationt(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein
12  diseases for FCRL4: About MalaCardsnon-hodgkin lymphoma hodgkin's lymphoma multiple myeloma myeloma
acute lymphoblastic leukemia chronic lymphocytic leukemia lymphoblastic leukemia lymphocytic leukemia
hepatitis b leukemia hepatitis malaria
Human Genome Epidemiology (HuGE) Navigator: FCRL4 (3 documents)
Export disorders for FCRL4 gene to outside databases
|
Publications
for FCRL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCRL4 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with FCRL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PubMed id 11290337)1, 2, 3 Hatzivassiliou G....Dalla-Favera R. (2001)
- Identification of a family of Fc receptor homologs with preferential B cell expression. (PubMed id 11493702)1, 2, 3 Davis R.S....Cooper M.D. (2001)
- IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PubMed id 11929751)1, 2, 9 Miller I....Dalla-Favera R. (2002)
- Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). (PubMed id 12881317)1, 2, 9 Falini B....Cattoretti G. (2003)
- Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (PubMed id 16849395)1, 2 Polson A.G.... Ebens A. (2006)
- T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution. (PubMed id 16079106)1, 2 Joehrens K.... Stein H. (2005)
- Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells. (PubMed id 16157685)1, 2 Ehrhardt G.R....Cooper M.D. (2005)
- Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis. (PubMed id 12619161)1, 2 Lestou V.S....Horsman D.E. (2003)
- The inhibitory potential of Fc receptor homolog 4 on memory B cells. (PubMed id 14597715)1, 2 Ehrhardt G.R.A....Cooper M.D. (2003)
- A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1. (PubMed id 12037601)1, 2 Guselnikov S.V.... Taranin A.V. (2002)
|
External Searches for FCRL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCRL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCRL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCRL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FCRL4 gene:
Search GeneIP for patents involving FCRL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCRL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL4 |
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