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Aliases for FCRL4 Gene

Aliases for FCRL4 Gene

  • Fc Receptor Like 4 2 3
  • Fc Receptor-Like 4 2 3 5
  • Immune Receptor Translocation-Associated Protein 1 3 4
  • Fc Receptor Homolog 4 3 4
  • IFGP Family Protein 2 3 4
  • FcR-Like Protein 4 3 4
  • HIFGP2 3 4
  • FCRH4 3 4
  • IRTA1 3 4
  • Immunoglobulin Superfamily Receptor Translocation Associated 1 3
  • Immunoglobulin Superfamily Fc Receptor, Gp42 3
  • CD307d Antigen 4
  • CD307d 3
  • IGFP2 3
  • FcRL4 4
  • IFGP2 4

External Ids for FCRL4 Gene

Previous GeneCards Identifiers for FCRL4 Gene

  • GC01M154357
  • GC01M155811
  • GC01M128901

Summaries for FCRL4 Gene

Entrez Gene Summary for FCRL4 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCRL4 Gene

FCRL4 (Fc Receptor Like 4) is a Protein Coding gene. Diseases associated with FCRL4 include Hodgkin Lymphoma and Multiple Myeloma. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCRL4 Gene

  • May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Gene Wiki entry for FCRL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL4 Gene

Genomics for FCRL4 Gene

Regulatory Elements for FCRL4 Gene

Enhancers for FCRL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FCRL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FCRL4 Gene

157,573,749 bp from pter
157,598,080 bp from pter
24,332 bases
Minus strand

Genomic View for FCRL4 Gene

Genes around FCRL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL4 Gene

Proteins for FCRL4 Gene

  • Protein details for FCRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 4
    Protein Accession:
    Secondary Accessions:
    • Q96PJ3
    • Q96RE0

    Protein attributes for FCRL4 Gene

    515 amino acids
    Molecular mass:
    57224 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRL4 Gene


neXtProt entry for FCRL4 Gene

Proteomics data for FCRL4 Gene at MOPED

Post-translational modifications for FCRL4 Gene

Other Protein References for FCRL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FCRL4
  • Santa Cruz Biotechnology (SCBT) Antibodies for FCRL4

No data available for DME Specific Peptides for FCRL4 Gene

Domains & Families for FCRL4 Gene

Protein Domains for FCRL4 Gene

Suggested Antigen Peptide Sequences for FCRL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCRL4: view

Function for FCRL4 Gene

Molecular function for FCRL4 Gene

UniProtKB/Swiss-Prot Function:
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
genes like me logo Genes that share phenotypes with FCRL4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCRL4 Gene

Localization for FCRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FCRL4 Gene COMPARTMENTS Subcellular localization image for FCRL4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FCRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCRL4: view

Pathways & Interactions for FCRL4 Gene

SuperPathways for FCRL4 Gene

No Data Available

Interacting Proteins for FCRL4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000271532 Q96PJ5-FCRL4_HUMAN for FCRL4 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FCRL4 Gene


No data available for Pathways by source and SIGNOR curated interactions for FCRL4 Gene

Drugs & Compounds for FCRL4 Gene

No Compound Related Data Available

Transcripts for FCRL4 Gene

mRNA/cDNA for FCRL4 Gene

Unigene Clusters for FCRL4 Gene

Fc receptor-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL4 Gene

No ASD Table

Relevant External Links for FCRL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL4 Gene

mRNA expression in normal human tissues for FCRL4 Gene

mRNA differential expression in normal tissues according to GTEx for FCRL4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x14.2) and Spleen (x5.7).

Protein differential expression in normal tissues from HIPED for FCRL4 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL4 Gene

SOURCE GeneReport for Unigene cluster for FCRL4 Gene Hs.120260

mRNA Expression by UniProt/SwissProt for FCRL4 Gene

Tissue specificity: Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).
genes like me logo Genes that share expression patterns with FCRL4: view

Protein tissue co-expression partners for FCRL4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FCRL4 Gene

Orthologs for FCRL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FCRL4 35
  • 76.39 (n)
  • 64.19 (a)
(Canis familiaris)
Mammalia FCRL4 35
  • 76.12 (n)
  • 63.5 (a)
FCRL4 36
  • 63 (a)
(Pan troglodytes)
Mammalia FCRL4 35
  • 98.77 (n)
  • 97.86 (a)
FCRL4 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
-- 36
  • 36 (a)
-- 36
  • 36 (a)
-- 36
  • 37 (a)
-- 36
  • 44 (a)
-- 36
  • 30 (a)
(Gallus gallus)
Aves FCRL2 36
  • 36 (a)
Species with no ortholog for FCRL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL4 Gene

Gene Tree for FCRL4 (if available)
Gene Tree for FCRL4 (if available)

Paralogs for FCRL4 Gene

(4) SIMAP similar genes for FCRL4 Gene using alignment to 1 proteins: Pseudogenes for FCRL4 Gene

genes like me logo Genes that share paralogs with FCRL4: view

Variants for FCRL4 Gene

Sequence variations from dbSNP and Humsavar for FCRL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11582663 - 157,589,332(+) AGTGC(C/T)GATGA reference, missense
rs4561035 - 157,587,359(+) CTGAG(A/C/T)TTTCT reference, missense
rs2039401 - 157,578,533(-) CCCCA(A/G)AAAGG reference, missense
rs3811028 - 157,575,594(-) TGTCT(A/G/T)CTCTG reference, missense
rs14335 -- 157,575,060(-) TGGCT(A/G)CACAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FCRL4 Gene

Variant ID Type Subtype PubMed ID
esv2718507 CNV Deletion 23290073
nsv3154 CNV Insertion 18451855
esv2661330 CNV Deletion 23128226

Variation tolerance for FCRL4 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCRL4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL4 Gene

Disorders for FCRL4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FCRL4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
multiple myeloma
  • plasma cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search FCRL4 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. {ECO:0000269 PubMed:11290337}.
  • Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). {ECO:0000269 PubMed:12619161}.

Relevant External Links for FCRL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FCRL4: view

No data available for Genatlas for FCRL4 Gene

Publications for FCRL4 Gene

  1. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PMID: 11290337) Hatzivassiliou G. … Dalla-Favera R. (Immunity 2001) 2 3 4 67
  2. Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). (PMID: 12881317) Falini B. … Cattoretti G. (Blood 2003) 3 23
  3. IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells. (PMID: 11929751) Miller I. … Dalla-Favera R. (Blood 2002) 3 23
  4. Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis R.S. … Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  5. Case-only designs for exploring the interaction between FCRL4 gene and suspected environmental factors in patients with ankylosing spondylitis. (PMID: 25012527) Ding N. … Pan F. (Inflammation 2015) 3

Products for FCRL4 Gene

Sources for FCRL4 Gene