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FCRL3 Gene

protein-coding   GIFtS: 57
GCID: GC01M157646

Fc Receptor-Like 3

  See FCRL3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Receptor-Like 31 2     IFGP Family Protein 32 3
FCRH32 3 5     SH2 Domain-Containing Phosphatase Anchor Protein 22 3
FcR-Like Protein 32 3     CD307c2
Immune Receptor Translocation-Associated Protein 32 3     Fc Receptor-Like Protein 32
IFGP32 3     Immunoglobulin Superfamily Receptor Translocation Associated Protein 32
IRTA32 3     FcRH33
SPAP22 3     FcRL33
Fc Receptor Homolog 32 3     CD307c Antigen3
hIFGP32 3     

External Ids:    HGNC: 185061   Entrez Gene: 1153522   Ensembl: ENSG000001608567   OMIM: 6065105   UniProtKB: Q96P313   

Export aliases for FCRL3 gene to outside databases

Previous GC identifers: GC01M154460 GC01M155912 GC01M129005


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCRL3 Gene:
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like
glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine
activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in
regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis,
autoimmune thyroid disease, and systemic lupus erythematosus. (provided by RefSeq, Jul 2008)

GeneCards Summary for FCRL3 Gene:
FCRL3 (Fc receptor-like 3) is a protein-coding gene. Diseases associated with FCRL3 include autoimmune pancreatitis, and juvenile rheumatoid arthritis. An important paralog of this gene is FCGR1B.

Gene Wiki entry for FCRL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCRL3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCRL3 promoter sequence
   Search Chromatin IP Primers for FCRL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCRL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21-q22

FCRL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCRL3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M157646:  view genomic region     (about GC identifiers)

Start:
157,644,111 bp from pter      End:
157,670,647 bp from pter
Size:
26,537 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCRL3_HUMAN, Q96P31 (See protein sequence)
Recommended Name: Fc receptor-like protein 3 precursor  
Size: 734 amino acids; 80856 Da
Subunit: Interacts with PTPN6, PTPN11, SYK and ZAP70
Secondary accessions: A0N0M4 A8MTH7 D3DVD2 Q5VXZ8 Q8N6S2 Q96LA4 Q96P27 Q96P28 Q96P29 Q96P30
Alternative splicing: 7 isoforms:  Q96P31-1   Q96P31-2   Q96P31-3   Q96P31-4   Q96P31-5   Q96P31-6   Q96P31-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCRL3: NX_Q96P31

Explore proteomics data for FCRL3 at MOPED

Post-translational modifications: 

  • Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein
    tyrosine kinases1
  • Glycosylation2 at Asn561
  • Modification sites at PhosphoSitePlus

  • See FCRL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443171.2  
    ENSEMBL proteins: 
     ENSP00000433430   ENSP00000435487   ENSP00000357169   ENSP00000434331   ENSP00000357167  
     ENSP00000473680  

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    Cloud-Clone Corp. Proteins for FCRL3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96P31

    ProtoNet protein and cluster: Q96P31

    2 Blocks protein domains:
    IPB002052 N-6 Adenine-specific DNA methylase
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: FCRL3_HUMAN, Q96P31
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCRL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FCRL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FCRL3:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Fcrl5 (no phenotypes)

    Find genes that share phenotypes with FCRL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fcrl5tm1Lex for FCRL3

       genOway: Develop your customized and physiologically relevant rodent model for FCRL3

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    hsa-miR-4261
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCRL3_HUMAN, Q96P31: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FCRL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCRL3
    Interactions:

        Search GeneGlobe Interaction Network for FCRL3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for FCRL3 (Q96P313 ENSP000003571674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    SYKP434053, ENSP000003648984I2D: score=1 STRING: ENSP00000364898
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCRL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCRL3 gene (2 alternative transcripts): 
    NM_052939.3  NM_001024667.1  

    Unigene Cluster for FCRL3:

    Fc receptor-like 3
    Hs.292449  [show with all ESTs]
    Unigene Representative Sequence: NM_052939
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457799 ENST00000477837 ENST00000492769 ENST00000480682 ENST00000494724
    ENST00000368186 ENST00000485028 ENST00000368184(uc001fqx.4 uc001fqy.4 uc001fqz.4 uc009wsn.3 uc009wso.3 uc001frb.3)
    ENST00000473231(uc001fra.3) ENST00000468507 ENST00000478179 ENST00000496769

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate FCRL3:
    hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidFCRL3 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat FCRL3

    Additional mRNA sequence: 

    AF459027.1 AK098122.1 AK125622.1 AK301257.1 AY043466.1 BC013698.1 BC028933.1 

    11 DOTS entries:

    DT.97839192  DT.99936266  DT.99956633  DT.92325152  DT.100017548  DT.95156352  DT.97839193  DT.97839190 
    DT.95090097  DT.95156353  DT.97839195 

    Selected AceView cDNA sequences (see all 55):

    AK098122 BM455913 NM_052939 BM458414 BC028933 AF459027 AA765694 BM458374 
    AW403530 AA972108 AL833391 AW576446 AA485705 AI357107 AA485839 BF514552 
    AF416905 AF416902 BX496349 CF121924 AF416901 AF416904 AW504347 BG105889 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FCRL3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                                      
    SP2:                                      -                                                               
    SP3:                                            -     -     -                                             
    SP4:                                                                                                      
    SP5:        -                                                                                             


    ECgene alternative splicing isoforms for FCRL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCRL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTGCTCTA
    FCRL3 Expression
    About this image


    FCRL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
    FCRL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCRL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292449

    UniProtKB/Swiss-Prot: FCRL3_HUMAN, Q96P31
    Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in
    spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and
    uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at
    protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FCRL3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcrl55 Fc receptor-like 5   --   3 (38.19 cM) 87435885 
    chicken
    (Gallus gallus)
    Aves FCRL21 Fc receptor-like 2 49.73(n)
    39.04(a)
      425592  NM_001097529.2  NP_001090998.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004941321 Fc receptor-like protein 5-like 46.75(n)
    37.34(a)
      100494132  XM_002940480.2  XP_002940526.2 


    ENSEMBL Gene Tree for FCRL3 (if available)
    TreeFam Gene Tree for FCRL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCRL3 gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  
    FCRL42  FCGR2A2  FCGR1A2  FCGR3A2  FCER1A2  FCRL62  
    13 SIMAP similar genes for FCRL3 using alignment to 4 protein entries:     FCRL3_HUMAN (see all proteins):
    FCRL1    FCRL2    FLJ00333    FCRL4    FCGR3A    FCGR3B
    FCRLB    DKFZp686L20250    FCGR2A    FCGR2B    FCGR1A    Fc-gamma receptor IIIB
    FCRL6

    Find genes that share paralogs with FCRL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCRL3 (see all 627)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0429264
    A breast cancer sample4--see VAR_0429262 H N mis40--------
    rs120693701,2
    C,F,A--157651482(+) gtgccG/Acaata 1 -- int13Minor allele frequency- A:0.33NA 6
    rs341236361,2
    C--157656054(+) AAATT-/AAAAAA 1 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs357730731,2
    C,F--157656868(-) TTTGTC/TTAAGT 1 -- int14Minor allele frequency- T:0.50NA WA 8
    rs748013301,2
    C--157657363(-) TATACC/TGCATT 1 -- int17Minor allele frequency- T:0.00WA NA CSA 11
    rs608729221,2
    C--157671559(+) ATTAT-/TATGTTCT 1 -- us2k10--------
    rs112647931,2
    C,F,A,H--164146785(+) AAAAAA/TTTATC 1 -- ds500124Minor allele frequency- N:0.01NS EA NA WA 2560
    rs1126557611,2
    C,F--164146870(+) AATATG/AATAGA 1 -- ds50012Minor allele frequency- A:0.09CSA WA 120
    rs1400707951,2
    C--164146950(+) GAAGAG/TAATGG 1 -- ds50010--------
    rs1871869081,2
    --164146989(+) TGTCTC/TGGGGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FCRL3 (157644111 - 157670647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FCRL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520011CNV Loss19592680

    Human Gene Mutation Database (HGMD): FCRL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCRL3
    DNA2.0 Custom Variant and Variant Library Synthesis for FCRL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606510    OMIM disorders: --

    UniProtKB/Swiss-Prot: FCRL3_HUMAN, Q96P31
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex
    genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial
    membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal
    tissues, and by atrophy and rarefaction of bony structures. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry
  • Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves
    disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and
    hyperthyroidism

  • 9 diseases for FCRL3:    
    About MalaCards
    autoimmune pancreatitis    juvenile rheumatoid arthritis    alopecia areata    rheumatoid arthritis
    autoimmune hepatitis    lupus erythematosus    systemic lupus erythematosus    arthritis
    primary biliary cirrhosis

    2 diseases from the University of Copenhagen DISEASES database for FCRL3:
    Rheumatoid arthritis     Graves' disease

    Find genes that share disorders with FCRL3           About GenesLikeMe

    5 Novoseek inferred disease relationships for FCRL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune thyroid disease 74.6 5 17117947 (1), 17133579 (1), 17462505 (1)
    autoimmune diseases 71.8 19 17200162 (2), 17462505 (2), 17389014 (1), 17868046 (1) (see all 14)
    rheumatoid arthritis 62.2 16 15838509 (2), 16859508 (1), 17117947 (1), 17200162 (1) (see all 11)
    lupus erythematosus systemic 55.2 7 17117947 (1), 18556175 (1), 19690864 (1), 17462505 (1) (see all 5)
    autoimmunity 42 7 17200162 (2), 15838509 (2), 17462505 (2)

    Genetic Association Database (GAD): FCRL3
    Human Genome Epidemiology (HuGE) Navigator: FCRL3 (38 documents)

    Export disorders for FCRL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCRL3 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with FCRL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. (PubMed id 17133579)1, 2, 4, 9 Newman W.G.... Siminovitch K.A. (Arthritis Rheum. 2006)
    2. FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians. (PubMed id 17179172)1, 2, 4, 9 Thabet M.M.... Huizinga T.W.J. (Ann. Rheum. Dis. 2007)
    3. Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis. (PubMed id 16476711)1, 2, 4, 9 Martinez A....Martin J. (Ann. Rheum. Dis. 2006)
    4. Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? (PubMed id 16859508)1, 2, 4, 9 Eyre S.... Barton A. (Arthritis Res. Ther. 2006)
    5. Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis. (PubMed id 16176992)1, 2, 4, 9 Ikari K....Kamatani N. (Ann. Rheum. Dis. 2006)
    6. Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. (PubMed id 16384851)1, 2, 4 Simmonds M.J....Gough S.C.L. (J. Clin. Endocrinol. Metab. 2006)
    7. Identification of a family of Fc receptor homologs with preferential B cell expression. (PubMed id 11493702)1, 2, 3 Davis R.S.... Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    8. Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association. (PubMed id 17200162)1, 4, 9 Owen C.J....Merriman T.R. (J. Clin. Endocrinol. Metab. 2007)
    9. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. (PubMed id 15838509)1, 2, 9 Kochi Y.... Yamamoto K. (Nat. Genet. 2005)
    10. Investigation of the functional variant c.-169T &gt; C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata. (PubMed id 17117947)1, 4, 9 SchAofer N....Betz R.C. (Int. J. Immunogenet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115352 HGNC: 18506 AceView: FCRH3 Ensembl:ENSG00000160856 euGenes: HUgn115352
    ECgene: FCRL3 H-InvDB: FCRL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FCRL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCRL3 gene:
    Search GeneIP for patents involving FCRL3

    GeneCards and IP:
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