Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCRL2 Gene

protein-coding   GIFtS: 49
GCID: GC01M157715

Fc Receptor-Like 2

(Previous name: SH2 domain-containing phosphatase anchor protein 1)
(Previous symbol: SPAP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fc Receptor-Like 21 2     SPAP1B2 5
SPAP11 2 3 5     SPAP1C2 5
SH2 Domain-Containing Phosphatase Anchor Protein 11 2 3     CD307b2
Fc Receptor Homolog 22 3     Fc Receptor-Like Protein 22
FcR-Like Protein 22 3     Immune Receptor Translocation-Associated Protein 42
Immunoglobulin Receptor Translocation-Associated Protein 42 3     Immunoglobulin Superfamily Fc Receptor, Gp422
FCRH22 3     SH2 Domain Containing Phosphatase Anchor Protein 12
IFGP42 3     FcRH23
IRTA42 3     FcRL23
IFGP Family Protein 42 3     CD307b Antigen3
SPAP1A2 5     

External Ids:    HGNC: 148751   Entrez Gene: 793682   Ensembl: ENSG000001327047   OMIM: 6065095   UniProtKB: Q96LA53   

Export aliases for FCRL2 gene to outside databases

Previous GC identifers: GC01P158425 GC01M154530 GC01M155982 GC01M129073


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCRL2 Gene:
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like
glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type
immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine
activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for
chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological
validity has not been determined. (provided by RefSeq, Apr 2009)

GeneCards Summary for FCRL2 Gene: 
FCRL2 (Fc receptor-like 2) is a protein-coding gene. Diseases associated with FCRL2 include chronic lymphocytic leukemia, and hiv type 1. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
Function: May have an regulatory role in normal and neoplastic B cell development

Gene Wiki entry for FCRL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCRL2 gene promoter:
         SRF   SRF (504 AA)   Meis-1b   GATA-1   NF-AT4   NF-AT2   NF-AT3   Meis-1a   Meis-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCRL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FCRL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

FCRL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCRL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M157715:  view genomic region     (about GC identifiers)

Start:
157,715,523 bp from pter      End:
157,746,922 bp from pter
Size:
31,400 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5 (See protein sequence)
Recommended Name: Fc receptor-like protein 2 precursor  
Size: 508 amino acids; 55542 Da
Subunit: The tyrosine-phosphorylated isoform 2 interacts with PTPN6
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: A0N0M5 A1L307 A6NMS0 Q6NTA1 Q9BZI4 Q9BZI5 Q9BZI6
Alternative splicing: 5 isoforms:  Q96LA5-1   Q96LA5-2   Q96LA5-3   Q96LA5-4   Q96LA5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCRL2: NX_Q96LA5

Explore proteomics data for FCRL2 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 2 is N- and O-glycosylated, and phosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LA5

  • FCRL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FCRL2 Protein Expression
    REFSEQ proteins: NP_110391.2  
    ENSEMBL proteins: 
     ENSP00000355157   ENSP00000357163   ENSP00000417393   ENSP00000376100  

    Human Recombinant Protein Products for FCRL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCRL2 (FCRL2/FcRH2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FCRL2
    OriGene Protein Over-expression Lysate for FCRL2
    OriGene MassSpec for FCRL2 
    OriGene Custom Protein Services for FCRL2
    GenScript Custom Purified and Recombinant Proteins Services for FCRL2
    Novus Biologicals FCRL2 Protein
    Novus Biologicals FCRL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FCRL2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane NAS11162587

    FCRL2 for ontologies           About GeneDecksing



    FCRL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FCRL2 (FCRL2/FcRH2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FCRL2
    GenScript Custom Superior Antibodies Services for FCRL2
    Novus Biologicals FCRL2 Antibody
    Abcam antibodies for FCRL2
    Cloud-Clone Corp. Antibodies for FCRL2 
    ThermoFisher Antibodies for FCRL2
    Search LSBio for Antibodies for FCRL2 

    Assay Products for FCRL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FCRL2
    R&D Systems Proteome Profiler Antibody Arrays for FCRL2 (FCRL2/FcRH2)
    GenScript Custom Assay Services for FCRL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FCRL2 
    Cloud-Clone Corp. CLIAs for FCRL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96LA5

    ProtoNet protein and cluster: Q96LA5

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
    Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    FCRL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCRL2_HUMAN, Q96LA5
    Function: May have an regulatory role in normal and neoplastic B cell development

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IPI11162587
    GO:0005515protein binding ----
         
    FCRL2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FCRL2:
     Decreased homologous recombina  Decreased number of cells in m  Increased G1 DNA content  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FCRL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FCRL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCRL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCRL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCRL2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate FCRL2:
    hsa-miR-145*
    SwitchGear 3'UTR luciferase reporter plasmidFCRL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FCRL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCRL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCRL2
    Sirion Biotech Customized adenovirus for overexpression of FCRL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FCRL2 (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FCRL2 (NM_030764)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCRL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCRL2
    Sirion Biotech Customized lentivirus for stable overexpression of FCRL2 
                         Customized lentivirus expression plasmids for stable overexpression of FCRL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCRL2
    Search LifeMap BioReagents cell lines for FCRL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCRL2

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling NAS11162587

    FCRL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCRL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCRL2

    1 Novoseek inferred chemical compound relationship for FCRL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37.2 6 18424727 (1), 10604985 (1), 11162587 (1)

    Search CenterWatch for drugs/clinical trials and news about FCRL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCRL2 gene (2 alternative transcripts): 
    NM_030764.3  NM_138738.3  

    Unigene Cluster for FCRL2:

    Fc receptor-like 2
    Hs.437393  [show with all ESTs]
    Unigene Representative Sequence: AL833194
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368178(uc001frd.2) ENST00000361516(uc001fre.2 uc010phz.1)
    ENST00000368181(uc009wsp.2) ENST00000469986 ENST00000462774(uc010pia.1)
    ENST00000392274
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCRL2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate FCRL2:
    hsa-miR-145*
    SwitchGear 3'UTR luciferase reporter plasmidFCRL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FCRL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCRL2
    Clone
    Products:
         
    OriGene clones in human, mouse for FCRL2 (see all 9)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FCRL2 (NM_030764)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCRL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCRL2
    Sirion Biotech Customized lentivirus for stable overexpression of FCRL2 
                         Customized lentivirus expression plasmids for stable overexpression of FCRL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FCRL2
    OriGene qSTAR qPCR primer pairs in human, mouse for FCRL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FCRL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCRL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCRL2

    Additional mRNA sequence: 

    AF319438.1 AF319439.1 AF319440.1 AF390037.1 AF459633.1 AK301113.1 AK303549.1 AL833194.1 
    AL833361.1 AY043465.1 AY358130.1 BC069185.1 BC129836.1 

    7 DOTS entries:

    DT.75158645  DT.97838279  DT.101980608  DT.100021225  DT.100021227  DT.303508  DT.121326230 

    24/40 AceView cDNA sequences (see all 40):

    AY043465 BQ882025 AW016722 AI968921 NM_138739 AF319439 BE466867 AA825460 
    AI630866 BQ059772 AL833361 AA808252 BQ056941 AF319440 NM_030764 BP345460 
    AF459633 AA830916 AA830105 AL833194 AW401599 AW085092 BQ016747 AY358130 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FCRL2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                          -     -                                         -                           
    SP2:                                                                          -                           
    SP3:                          -     -     -     -                                                         
    SP4:              -     -     -     -     -     -     -     -                 -                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for FCRL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCRL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCTGGAG
    FCRL2 Expression
    About this image


    See FCRL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCRL2

    SOURCE GeneReport for Unigene cluster: Hs.437393

    UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
    Tissue specificity: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to
    the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is
    expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines.
    Preferentially expressed in memory B-cells (at protein level)

        SABiosciences Custom PCR Arrays for FCRL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FCRL2
    OriGene qSTAR qPCR primer pairs in human, mouse for FCRL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FCRL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCRL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCRL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for FCRL2 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FCRL21 Fc receptor-like 2 78.15(n)
    66.73(a)
      612038  XM_849766.2  XP_854859.2 


    ENSEMBL Gene Tree for FCRL2 (if available)
    TreeFam Gene Tree for FCRL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCRL2 gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL12  FCRLA2  FCRL52  FCRL42  
    FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    6 SIMAP similar genes for FCRL2 using alignment to 2 protein entries:     FCRL2_HUMAN (see all proteins):
    FCRL1    FCRL3    FLJ00333    FCRL5    FCGR1A    FCRL4

    FCRL2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FCRL2
    PGOHUM00000244288 PGOHUM00000244289


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/883 SNPs in FCRL2 are shown (see all 883)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867214801,2
    --129072912(+) TAAAAG/TTTTTC 1 -- ds50010--------
    rs796014391,2
    C,F--129073001(+) ACCTAT/ATGAGG 1 -- ds50013Minor allele frequency- A:0.15WA CSA 121
    rs1916117951,2
    --157715085(+) GAGATC/TGAGAC 1 -- ds50010--------
    rs1841460071,2
    --157715106(+) AACACA/GGTGAA 1 -- ds50010--------
    rs1895756841,2
    C--157715145(+) TTAGCA/CGGGGG 1 -- ds50010--------
    rs1120740831,2
    C,F--157715177(+) CCAGCT/CACTTG 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1816753521,2
    --157715223(+) GGCGAA/GCTTGC 1 -- ds50010--------
    rs597445501,2
    C--157715253(+) ACTGCA/GCTCCA 1 -- ds50010--------
    rs1139286041,2
    C--157715285(+) CCGTC-/A/AA  
            
    AAAAA
    1 -- ds50011CSA 2
    rs1999626011,2
    C--157715295(+) AAAAA-/AGAAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FCRL2 (157715523 - 157746922 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FCRL2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FCRL2
    DNA2.0 Custom Variant and Variant Library Synthesis for FCRL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606509    OMIM disorders: --

    10 diseases for FCRL2:    About MalaCards
    chronic lymphocytic leukemia    hiv type 1    b-cell chronic lymphocytic leukemia    tonsillitis
    leukemia    acute lymphoblastic leukemia    lymphoblastic leukemia    hepatitis b
    hepatitis    endotheliitis


    FCRL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FCRL2
    Human Genome Epidemiology (HuGE) Navigator: FCRL2 (5 documents)

    Export disorders for FCRL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCRL2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with FCRL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PubMed id 11162587)1, 2, 3, 9 Xu M.-J.... Zhao Z.J. (2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PubMed id 11929751)1, 2 Miller I....Dalla-Favera R. (2002)
    7. A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1. (PubMed id 12037601)1, 2 Guselnikov S.V.... Taranin A.V. (2002)
    8. Identification of a family of Fc receptor homologs with preferential B cell expression. (PubMed id 11493702)1, 2 Davis R.S....Cooper M.D. (2001)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    10. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79368 HGNC: 14875 AceView: SPAP1 Ensembl:ENSG00000132704 euGenes: HUgn79368
    ECgene: FCRL2 H-InvDB: FCRL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCRL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCRL2 gene:
    Search GeneIP for patents involving FCRL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FCRL2 (FCRL2/FcRH2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for FCRL2 (FCRL2/FcRH2)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for FCRL2 (FCRL2/FcRH2)   Proteome Profiler Antibody Arrays for FCRL2 (FCRL2/FcRH2)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FCRL2  
     OriGene qPCR primer pairs and template standards for FCRL2   OriGene Protein Over-expression Lysate for FCRL2  
     OriGene MassSpec something-or-other for FCRL2   OriGene clones in human, mouse for FCRL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FCRL2   OriGene Purified Protein for FCRL2  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCRL2   OriGene Custom Protein Services for FCRL2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCRL2
     QIAGEN SeqTarget long-range PCR primers for resequencing FCRL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCRL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCRL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCRL2
     GenScript Custom Purified and Recombinant Proteins Services for FCRL2 GenScript cDNA clones with any tag delivered in your preferred vector for FCRL2
     GenScript Custom Assay Services for FCRL2 GenScript Custom Superior Antibodies Services for FCRL2
     GenScript Custom overexpressing Cell Line Services for FCRL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FCRL2 promoter
     Search Chromatin IP Primers for FCRL2
     RT2 qPCR Primer Assay in human, mouse / rat FCRL2
     Search GNC Networks for FCRL2
     SABiosciences Custom PCR Arrays for FCRL2
     Search Tocris compounds for FCRL2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FCRL2 antibodies
     FCRL2 proteins
     FCRL2 lysates
     Antibodies for FCRL2
     See all of Abcam's Antibodies, Kits and Proteins for FCRL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FCRL2
     Antibodies for FCRL2
     ELISAs for FCRL2
     CLIAs for FCRL2
     Search LifeMap BioReagents cell lines for FCRL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL2
     SwitchGear 3'UTR luciferase reporter plasmids for FCRL2
     SwitchGear Promoter luciferase reporter plasmids for FCRL2
     ThermoFisher Antibodies for FCRL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCRL2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FCRL2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FCRL2
    Customized:
     lentivirus for stable overexpression of FCRL2
     lentivirus expression plasmids for stable overexpression of FCRL2
     adenovirus for overexpression of FCRL2
     Search LSBio for Antibodies for FCRL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FCRL2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4