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FCRL2 Gene

protein-coding   GIFtS: 51
GCID: GC01M157715

Fc Receptor-Like 2

(Previous name: SH2 domain-containing phosphatase anchor protein 1)
(Previous symbol: SPAP1)
  See FCRL2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Receptor-Like 21 2     SPAP1B2 5
SPAP11 2 3 5     SPAP1C2 5
SH2 Domain-Containing Phosphatase Anchor Protein 11 2 3     CD307b2
Fc Receptor Homolog 22 3     Fc Receptor-Like Protein 22
FcR-Like Protein 22 3     Immune Receptor Translocation-Associated Protein 42
Immunoglobulin Receptor Translocation-Associated Protein 42 3     Immunoglobulin Superfamily Fc Receptor, Gp422
FCRH22 3     SH2 Domain Containing Phosphatase Anchor Protein 12
IFGP42 3     FcRH23
IRTA42 3     FcRL23
IFGP Family Protein 42 3     CD307b Antigen3
SPAP1A2 5     

External Ids:    HGNC: 148751   Entrez Gene: 793682   Ensembl: ENSG000001327047   OMIM: 6065095   UniProtKB: Q96LA53   

Export aliases for FCRL2 gene to outside databases

Previous GC identifers: GC01P158425 GC01M154530 GC01M155982 GC01M129073


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCRL2 Gene:
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like
glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type
immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine
activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for
chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological
validity has not been determined. (provided by RefSeq, Apr 2009)

GeneCards Summary for FCRL2 Gene:
FCRL2 (Fc receptor-like 2) is a protein-coding gene. Diseases associated with FCRL2 include chronic lymphocytic leukemia. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
Function: May have an regulatory role in normal and neoplastic B cell development

Gene Wiki entry for FCRL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCRL2 gene promoter:
         SRF   SRF (504 AA)   Meis-1b   GATA-1   NF-AT4   NF-AT2   NF-AT3   Meis-1a   Meis-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCRL2 promoter sequence
   Search Chromatin IP Primers for FCRL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCRL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

FCRL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCRL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M157715:  view genomic region     (about GC identifiers)

Start:
157,715,523 bp from pter      End:
157,746,922 bp from pter
Size:
31,400 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5 (See protein sequence)
Recommended Name: Fc receptor-like protein 2 precursor  
Size: 508 amino acids; 55542 Da
Subunit: The tyrosine-phosphorylated isoform 2 interacts with PTPN6
Secondary accessions: A0N0M5 A1L307 A6NMS0 Q6NTA1 Q9BZI4 Q9BZI5 Q9BZI6
Alternative splicing: 5 isoforms:  Q96LA5-1   Q96LA5-2   Q96LA5-3   Q96LA5-4   Q96LA5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCRL2: NX_Q96LA5

Explore proteomics data for FCRL2 at MOPED

Post-translational modifications: 

  • Isoform 2 is N- and O-glycosylated, and phosphorylated1
  • Glycosylation2 at Asn204, Asn234, Asn343, Asn355, Asn365
  • Modification sites at PhosphoSitePlus

  • See FCRL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110391.2  
    ENSEMBL proteins: 
     ENSP00000355157   ENSP00000357163   ENSP00000417393   ENSP00000376100  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96LA5

    ProtoNet protein and cluster: Q96LA5

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
    Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCRL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCRL2_HUMAN, Q96LA5
    Function: May have an regulatory role in normal and neoplastic B cell development

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IPI11162587
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FCRL2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FCRL2:
     Decreased homologous recombina  Decreased number of cells in m  Increased G1 DNA content  Increased cell death HMECs cel 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCRL2_HUMAN, Q96LA5: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane NAS11162587

    Find genes that share ontologies with FCRL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCRL2
    Interactions:

        Search GeneGlobe Interaction Network for FCRL2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for FCRL2 (ENSP000003551574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNE1ENSP000002626434STRING: ENSP00000262643
    CCNE2ENSP000003091814STRING: ENSP00000309181
    EVX1ENSP000004192664STRING: ENSP00000419266
    EVX2ENSP000003123854STRING: ENSP00000312385
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling NAS11162587
    GO:0009967positive regulation of signal transduction IPI11162587

    Find genes that share ontologies with FCRL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCRL2

    1 Novoseek inferred chemical compound relationship for FCRL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37.2 6 18424727 (1), 10604985 (1), 11162587 (1)



    Find genes that share compounds with FCRL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCRL2 gene (2 alternative transcripts): 
    NM_030764.3  NM_138738.3  

    Unigene Cluster for FCRL2:

    Fc receptor-like 2
    Hs.437393  [show with all ESTs]
    Unigene Representative Sequence: AL833194
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368178(uc001frd.2) ENST00000361516(uc001fre.2 uc010phz.1)
    ENST00000368181(uc009wsp.2) ENST00000469986 ENST00000462774(uc010pia.1)
    ENST00000392274
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FCRL2
      QuantiFast Probe-based Assays in human, mouse, rat FCRL2

    Additional mRNA sequence: 

    AF319438.1 AF319439.1 AF319440.1 AF390037.1 AF459633.1 AK301113.1 AK303549.1 AL833194.1 
    AL833361.1 AY043465.1 AY358130.1 BC069185.1 BC129836.1 

    7 DOTS entries:

    DT.75158645  DT.97838279  DT.101980608  DT.100021225  DT.100021227  DT.303508  DT.121326230 

    Selected AceView cDNA sequences (see all 40):

    AI630866 NM_030764 AF459633 AW016722 AA808252 BP345460 BE466867 AY043465 
    NM_138739 AI968921 BQ059772 AA830105 BQ882025 AF319439 AA825460 AL833194 
    BQ056941 AF319440 AL833361 AA830916 NM_138738 BU941782 BQ016747 AW072367 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FCRL2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                          -     -                                         -                           
    SP2:                                                                          -                           
    SP3:                          -     -     -     -                                                         
    SP4:              -     -     -     -     -     -     -     -                 -                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for FCRL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCRL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCTGGAG
    FCRL2 Expression
    About this image


    FCRL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    FCRL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCRL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437393

    UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
    Tissue specificity: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to
    the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is
    expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines.
    Preferentially expressed in memory B-cells (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FCRL2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FCRL26
    Gallus gallus Fc receptor-like 2 (FCRL2), mRNA.
    27(a)
    1 → many
    25(1587904-1591630)
            Species with no ortholog for FCRL2

    ENSEMBL Gene Tree for FCRL2 (if available)
    TreeFam Gene Tree for FCRL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCRL2 gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL12  FCRLA2  FCRL52  FCRL42  
    FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    6 SIMAP similar genes for FCRL2 using alignment to 2 protein entries:     FCRL2_HUMAN (see all proteins):
    FCRL1    FCRL3    FLJ00333    FCRL5    FCGR1A    FCRL4

    Find genes that share paralogs with FCRL2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FCRL2
    PGOHUM00000244288 PGOHUM00000244289


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCRL2 (see all 883)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867214801,2
    --129072912(+) TAAAAG/TTTTTC 1 -- ds50010--------
    rs796014391,2
    C,F--129073001(+) ACCTAT/ATGAGG 1 -- ds50013Minor allele frequency- A:0.15WA CSA 121
    rs1916117951,2
    --157715085(+) GAGATC/TGAGAC 1 -- ds50010--------
    rs1841460071,2
    --157715106(+) AACACA/GGTGAA 1 -- ds50010--------
    rs1895756841,2
    C--157715145(+) TTAGCA/CGGGGG 1 -- ds50010--------
    rs1120740831,2
    C,F--157715177(+) CCAGCT/CACTTG 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1816753521,2
    --157715223(+) GGCGAA/GCTTGC 1 -- ds50010--------
    rs597445501,2
    C--157715253(+) ACTGCA/GCTCCA 1 -- ds50010--------
    rs1139286041,2
    C--157715285(+) CCGTC-/A/AA  
            
    AAAAA
    1 -- ds50011CSA 2
    rs1999626011,2
    C--157715295(+) AAAAA-/AGAAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FCRL2 (157715523 - 157746922 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FCRL2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCRL2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606509    OMIM disorders: --

    1 disease for FCRL2:    
    About MalaCards
    chronic lymphocytic leukemia


    Find genes that share disorders with FCRL2           About GenesLikeMe

    Genetic Association Database (GAD): FCRL2
    Human Genome Epidemiology (HuGE) Navigator: FCRL2 (5 documents)

    Export disorders for FCRL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCRL2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FCRL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PubMed id 11162587)1, 2, 3, 9 Xu M.-J.... Zhao Z.J. (Biochem. Biophys. Res. Commun. 2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells. (PubMed id 11929751)1, 2 Miller I....Dalla-Favera R. (Blood 2002)
    7. A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1. (PubMed id 12037601)1, 2 Guselnikov S.V.... Taranin A.V. (Immunogenetics 2002)
    8. Identification of a family of Fc receptor homologs with preferential B cell expression. (PubMed id 11493702)1, 2 Davis R.S.... Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    10. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79368 HGNC: 14875 AceView: SPAP1 Ensembl:ENSG00000132704 euGenes: HUgn79368
    ECgene: FCRL2 H-InvDB: FCRL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCRL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCRL2 gene:
    Search GeneIP for patents involving FCRL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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