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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCRL2 Gene

protein-coding   GIFtS: 49
GCID: GC01M157715

Fc receptor-like 2

(Previous name: SH2 domain-containing phosphatase anchor protein 1 )
(Previous symbol: SPAP1)
 Explore 9 diseases affiliated with
FCRL2 via our new
 Human Malady Compendium 
Biological research products
for FCRL2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fc Receptor-Like 21 2     SPAP1A2 5
SPAP11 2 3 5     SPAP1B2 5
FCRH21 2 3     SPAP1C2 5
IRTA41 2 3     Fc Receptor-Like Protein 22
SH2 Domain-Containing Phosphatase Anchor Protein 11 2 3     Immune Receptor Translocation-Associated Protein 42
CD307b1 2     Immunoglobulin Superfamily Fc Receptor, Gp422
Fc Receptor Homolog 22 3     SH2 Domain Containing Phosphatase Anchor Protein 12
FcR-Like Protein 22 3     FcRH23
Immunoglobulin Receptor Translocation-Associated Protein 42 3     FcRL23
IFGP42 3     CD307b Antigen3
IFGP Family Protein 42 3     

External Ids:    HGNC: 148751   Entrez Gene: 793682   Ensembl: ENSG000001327047   OMIM: 6065095   UniProtKB: Q96LA53   

Export aliases for FCRL2 gene to outside databases

Previous GC identifers: GC01P158425 GC01M154530 GC01M155982 GC01M129073


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCRL2:
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like
glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type
immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine
activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for
chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological
validity has not been determined. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
Function: May have an regulatory role in normal and neoplastic B cell development

Gene Wiki entry for FCRL2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCRL2 gene promoter:
         SRF   SRF (504 AA)   Meis-1b   GATA-1   NF-AT4   NF-AT2   NF-AT3   Meis-1a   Meis-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCRL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FCRL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

FCRL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCRL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M157715:  view genomic region     (about GC identifiers)

Start:
157,715,523 bp from pter      End:
157,746,922 bp from pter
Size:
31,400 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5 (See protein sequence)
Recommended Name: Fc receptor-like protein 2 precursor  
Size: 508 amino acids; 55542 Da
Subunit: The tyrosine-phosphorylated isoform 2 interacts with PTPN6
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: A0N0M5 A1L307 A6NMS0 Q6NTA1 Q9BZI4 Q9BZI5 Q9BZI6
Alternative splicing: 5 isoforms:  Q96LA5-1   Q96LA5-2   Q96LA5-3   Q96LA5-4   Q96LA5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCRL2: NX_Q96LA5

Post-translational modifications:

  • Isoform 2 is N- and O-glycosylated, and phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96LA5

  • FCRL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_110391.2  
    ENSEMBL proteins: 
     ENSP00000355157   ENSP00000357163   ENSP00000417393   ENSP00000376100  

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    Uscn Proteins for FCRL2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane NAS11162587


    FCRL2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FCRL2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96LA5

    ProtoNet protein and cluster: Q96LA5

    1 Blocks protein family: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
    Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
    Function: May have an regulatory role in normal and neoplastic B cell development

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005070SH3/SH2 adaptor activity IPI11162587


    FCRL2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for FCRL2:
     Decreased homologous recombina  Decreased number of cells in m  Increased G1 DNA content  Increased cell death HMECs cel 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCRL2

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling NAS11162587


    FCRL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCRL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCRL2
    1 Novoseek chemical compound relationship for FCRL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37.2 6 18424727 (1), 10604985 (1), 11162587 (1)

    Search CenterWatch for drugs/clinical trials and news about FCRL2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCRL2 gene (2 alternative transcripts): 
    NM_030764.3  NM_138738.3  

    Unigene Cluster for FCRL2:

    Fc receptor-like 2
    Hs.437393  [show with all ESTs]
    Unigene Representative Sequence: AL833194
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368178(uc001frd.2) ENST00000361516(uc001fre.2 uc010phz.1)
    ENST00000368181(uc009wsp.2) ENST00000469986 ENST00000462774(uc010pia.1)
    ENST00000392274

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    Additional cDNA sequence: 

    AF319438.1 AF319439.1 AF319440.1 AF390037.1 AF459633.1 AK301113.1 AK303549.1 AL833194.1 
    AL833361.1 AY043465.1 AY358130.1 BC069185.1 BC129836.1 

    7 DOTS entries:

    DT.75158645  DT.97838279  DT.101980608  DT.100021225  DT.100021227  DT.303508  DT.121326230 

    24/40 AceView cDNA sequences (see all 40):

    AW016722 AA808252 AY043465 AL833361 AF319439 AL833194 AA825460 NM_138739 
    AF319440 BE466867 AF459633 BP345460 BQ059772 BQ056941 AI630866 BQ882025 
    AA830916 AI968921 AA830105 NM_030764 BQ055548 AW085092 AF319438 BQ016747 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FCRL2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                          -     -                                         -                           
    SP2:                                                                          -                           
    SP3:                          -     -     -     -                                                         
    SP4:              -     -     -     -     -     -     -     -                 -                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for FCRL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCRL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAGCTGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FCRL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCRL2

    SOURCE GeneReport for Unigene cluster: Hs.437393

    UniProtKB/Swiss-Prot: FCRL2_HUMAN, Q96LA5
    Tissue specificity: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the
    mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed
    in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially
    expressed in memory B-cells (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FCRL2 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    20(a)
    1 → many
    25(1707231-1709870)


    ENSEMBL Gene Tree for FCRL2 (if available)
    TreeFam Gene Tree for FCRL2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCRL2 gene
    FCGR2B2  FCGR1B2  FCGR3B2  FCRLB2  FCRL12  FCRL42  FCRL52  FCRLA2  
    FCGR1A2  FCGR2A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    6 SIMAP similar genes for FCRL2 using alignment to 2 protein entries:     FCRL2_HUMAN (see all proteins):
    FCRL1    FCRL3    FLJ00333    FCRL5    FCGR1A    FCRL4

    FCRL2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FCRL2
    PGOHUM00000244288 PGOHUM00000244289


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/727 NCBI SNPs in FCRL2 are shown (see all 727    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916117951,2
    --157715085(+) GAGATC/TGAGAC 1 -- ds50010--------
    rs1841460071,2
    --157715106(+) AACACA/GGTGAA 1 -- ds50010--------
    rs1895756841,2
    --157715145(+) TTAGCA/CGGGGG 1 -- ds50010--------
    rs1120740831,2
    --157715177(+) CCAGCT/CACTTG 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1816753521,2
    --157715223(+) GGCGAA/GCTTGC 1 -- ds50010--------
    rs597445501,2
    --157715253(+) ACTGCA/GCTCCA 1 -- ds50010--------
    rs777978571,2
    C,--157715344(+) ATGCTG/AATTAC 1 -- ds50013Minor allele frequency- A:0.15WA CSA 121
    rs1453451681,2
    --157715388(+) ACACCA/GAACCC 1 -- ds50010--------
    rs1852218551,2
    --157715431(+) CACACA/GTGTAC 1 -- ds50010--------
    rs784703621,2
    C,--157715434(+) ACATGT/AACCCC 1 -- ds50013Minor allele frequency- A:0.15WA CSA 121

    HapMap Linkage Disequilibrium report for FCRL2 (157715523 - 157746922 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FCRL2: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FCRL2 for disorders           About GeneDecksing

    OMIM gene information: 606509    OMIM disorders: --

    9 diseases for FCRL2:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    leukemia    acute lymphoblastic leukemia
    lymphoblastic leukemia    tonsillitis    hepatitis b    hepatitis
    hiv type 1

    Human Genome Epidemiology (HuGE) Navigator: FCRL2 (5 documents)

    Export disorders for FCRL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCRL2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with FCRL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PubMed id 11162587)1, 2, 3, 9 Xu M.-J.... Zhao Z.J. (2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PubMed id 11929751)1, 2 Miller I....Dalla-Favera R. (2002)
    7. A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1. (PubMed id 12037601)1, 2 Guselnikov S.V.... Taranin A.V. (2002)
    8. Identification of a family of Fc receptor homologs with preferential B cell expression. (PubMed id 11493702)1, 2 Davis R.S....Cooper M.D. (2001)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    10. FcR-like 2 Inhibition of B cell receptor-mediated act ivation of B cells. (PubMed id 21068405)1 Jackson T.A....Cooper M.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79368 HGNC: 14875 AceView: SPAP1 Ensembl:ENSG00000132704 euGenes: HUgn79368
    ECgene: FCRL2 H-InvDB: FCRL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCRL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCRL2 gene:
    Search GeneIP for patents involving FCRL2

    GeneCards and IP:
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