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Aliases for FCRL2 Gene

Aliases for FCRL2 Gene

  • Fc Receptor Like 2 2 3
  • Fc Receptor-Like 2 2 3 5
  • Immunoglobulin Receptor Translocation-Associated Protein 4 3 4
  • SH2 Domain-Containing Phosphatase Anchor Protein 1 2 4
  • Fc Receptor Homolog 2 3 4
  • IFGP Family Protein 4 3 4
  • SPAP1 3 4
  • FCRH2 3 4
  • IFGP4 3 4
  • IRTA4 3 4
  • SH2 Domain Containing Phosphatase Anchor Protein 1 3
  • Immune Receptor Translocation-Associated Protein 4 3
  • Immunoglobulin Superfamily Fc Receptor, Gp42 3
  • FcR-Like Protein 2 4
  • CD307b Antigen 4
  • CD307b 3
  • SPAP1A 3
  • SPAP1B 3
  • SPAP1C 3
  • FcRL2 4

External Ids for FCRL2 Gene

Previous HGNC Symbols for FCRL2 Gene

  • SPAP1

Previous GeneCards Identifiers for FCRL2 Gene

  • GC01P158425
  • GC01M154530
  • GC01M155982
  • GC01M129073

Summaries for FCRL2 Gene

Entrez Gene Summary for FCRL2 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCRL2 Gene

FCRL2 (Fc Receptor Like 2) is a Protein Coding gene. Diseases associated with FCRL2 include Chronic Lymphocytic Leukemia. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is FCRL4.

UniProtKB/Swiss-Prot for FCRL2 Gene

  • May have an regulatory role in normal and neoplastic B cell development.

Gene Wiki entry for FCRL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL2 Gene

Genomics for FCRL2 Gene

Regulatory Elements for FCRL2 Gene

Enhancers for FCRL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FCRL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FCRL2 Gene

157,745,733 bp from pter
157,777,439 bp from pter
31,707 bases
Minus strand

Genomic View for FCRL2 Gene

Genes around FCRL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL2 Gene

Proteins for FCRL2 Gene

  • Protein details for FCRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A0N0M5
    • A1L307
    • A6NMS0
    • Q6NTA1
    • Q9BZI4
    • Q9BZI5
    • Q9BZI6

    Protein attributes for FCRL2 Gene

    508 amino acids
    Molecular mass:
    55542 Da
    Quaternary structure:
    • The tyrosine-phosphorylated isoform 2 interacts with PTPN6.

    Alternative splice isoforms for FCRL2 Gene


neXtProt entry for FCRL2 Gene

Proteomics data for FCRL2 Gene at MOPED

Post-translational modifications for FCRL2 Gene

  • Isoform 2 is N- and O-glycosylated, and phosphorylated.
  • Glycosylation at Asn 204, Asn 234, Asn 343, Asn 355, and Asn 365
  • Modification sites at PhosphoSitePlus

Other Protein References for FCRL2 Gene

No data available for DME Specific Peptides for FCRL2 Gene

Domains & Families for FCRL2 Gene

Protein Domains for FCRL2 Gene

Suggested Antigen Peptide Sequences for FCRL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCRL2: view

Function for FCRL2 Gene

Molecular function for FCRL2 Gene

UniProtKB/Swiss-Prot Function:
May have an regulatory role in normal and neoplastic B cell development.

Gene Ontology (GO) - Molecular Function for FCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IPI 11162587
genes like me logo Genes that share ontologies with FCRL2: view
genes like me logo Genes that share phenotypes with FCRL2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL2 Gene

Localization for FCRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FCRL2 Gene COMPARTMENTS Subcellular localization image for FCRL2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FCRL2 Gene

Pathways & Interactions for FCRL2 Gene

SuperPathways for FCRL2 Gene

No Data Available

Interacting Proteins for FCRL2 Gene

Gene Ontology (GO) - Biological Process for FCRL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FCRL2 Gene

Drugs & Compounds for FCRL2 Gene

(1) Drugs for FCRL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FCRL2: view

Transcripts for FCRL2 Gene

Unigene Clusters for FCRL2 Gene

Fc receptor-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - - - - - - - -
SP6: - - - - -

Relevant External Links for FCRL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL2 Gene

mRNA expression in normal human tissues for FCRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL2 Gene

This gene is overexpressed in Spleen (x24.8), Small Intestine - Terminal Ileum (x17.5), and Whole Blood (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL2 Gene

SOURCE GeneReport for Unigene cluster for FCRL2 Gene Hs.437393

mRNA Expression by UniProt/SwissProt for FCRL2 Gene

Tissue specificity: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).
genes like me logo Genes that share expression patterns with FCRL2: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for FCRL2 Gene

Orthologs for FCRL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FCRL2 35
  • 78.15 (n)
  • 66.73 (a)
FCRL2 36
  • 69 (a)
(Pan troglodytes)
Mammalia FCRL2 35
  • 99.15 (n)
  • 98.43 (a)
FCRL2 36
  • 98 (a)
(Bos Taurus)
Mammalia FCRL2 36
  • 40 (a)
(Mus musculus)
Mammalia Fcrls 36
  • 38 (a)
(Gallus gallus)
Aves FCRL2 36
  • 27 (a)
Species with no ortholog for FCRL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL2 Gene

Gene Tree for FCRL2 (if available)
Gene Tree for FCRL2 (if available)

Paralogs for FCRL2 Gene

(6) SIMAP similar genes for FCRL2 Gene using alignment to 2 proteins: Pseudogenes for FCRL2 Gene

genes like me logo Genes that share paralogs with FCRL2: view

Variants for FCRL2 Gene

Sequence variations from dbSNP and Humsavar for FCRL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16839100 - 157,768,692(+) TAGAG(A/G/T)TGGGG intron-variant, reference, missense
rs1999791 -- 157,757,100(+) ACACT(A/T)TTTCT intron-variant
rs1999792 -- 157,757,123(+) TTTGG(G/T)TATGA intron-variant
rs2210909 -- 157,775,058(+) TAGAA(C/T)AGTAA intron-variant
rs2275232 -- 157,748,640(+) AGAGT(G/T)CACAG intron-variant

Variation tolerance for FCRL2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FCRL2 Gene

Disorders for FCRL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCRL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search FCRL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCRL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FCRL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCRL2 Gene

Publications for FCRL2 Gene

  1. Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PMID: 11162587) Xu M.-J. … Zhao Z.J. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells. (PMID: 21068405) Jackson T.A. … Cooper M.D. (J. Immunol. 2010) 3
  5. Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia. (PMID: 18802695) Kazemi T. … Shokri F. (Cancer Immunol. Immunother. 2009) 3

Products for FCRL2 Gene

Sources for FCRL2 Gene