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FCRL2 Gene(Protein Coding)

Fc Receptor Like 2

GCID:
GC01M157715
GIFtS:
54
Genes Participants
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Aliases for FCRL2 Gene

Aliases for FCRL2 Gene

  • Fc Receptor Like 2 2 3 5
  • Immunoglobulin Receptor Translocation-Associated Protein 4 3 4
  • SH2 Domain-Containing Phosphatase Anchor Protein 1 2 4
  • Fc Receptor Homolog 2 3 4
  • IFGP Family Protein 4 3 4
  • SPAP1 3 4
  • FCRH2 3 4
  • IFGP4 3 4
  • IRTA4 3 4
  • SH2 Domain Containing Phosphatase Anchor Protein 1 3
  • Immune Receptor Translocation-Associated Protein 4 3
  • Immunoglobulin Superfamily Fc Receptor, Gp42 3
  • Fc Receptor-Like Protein 2 3
  • Fc Receptor-Like 2 2
  • FcR-Like Protein 2 4
  • CD307b Antigen 4
  • CD307b 3
  • SPAP1A 3
  • SPAP1B 3
  • SPAP1C 3
  • FcRL2 4

External Ids for FCRL2 Gene

Previous HGNC Symbols for FCRL2 Gene

  • SPAP1

Previous GeneCards Identifiers for FCRL2 Gene

  • GC01P158425
  • GC01M154530
  • GC01M155982
  • GC01M129073

Summaries for FCRL2 Gene

Entrez Gene Summary for FCRL2 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCRL2 Gene

FCRL2 (Fc Receptor Like 2) is a Protein Coding gene. Diseases associated with FCRL2 include Chronic Lymphocytic Leukemia. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is FCRL3.

UniProtKB/Swiss-Prot for FCRL2 Gene

  • May have an regulatory role in normal and neoplastic B cell development.

Gene Wiki entry for FCRL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL2 Gene

Genomics for FCRL2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FCRL2 Gene

Enhancers for FCRL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G157721 1.2 Ensembl ENCODE dbSUPER 10.6 +53.0 53006 6.4 CTCF ZBTB7B RAD21 RELA GATA3 POLR2A SMC3 RELB IKZF2 ZNF654 FCRL3 ENSG00000227217 FCRL2 FCRL1 VDAC1P9 SONP1
GH01G157806 1 ENCODE dbSUPER 10.7 -29.6 -29618 1.1 PKNOX1 USF1 CHD4 CBX5 POLR2A EED ETV6 RELB IKZF2 MTA2 FCRL2 FCRL1
GH01G157595 0.8 ENCODE 10 +181.9 181904 0.1 TBL1XR1 WRNIP1 BMI1 CBX5 EED ETV6 RELB IKZF2 CREM CHD2 FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4
GH01G157733 0.7 ENCODE dbSUPER 10.8 +42.9 42864 2.1 PKNOX1 TBX21 FCRL3 FCRL2 ENSG00000227217 FCRL1 VDAC1P9 PIR43091
GH01G157849 0.4 Ensembl 10.7 -72.3 -72262 1.0 ZZZ3 SPI1 FCRL1 CD5L FCRL2 FCRL3 MRPS21P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCRL2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FCRL2 gene promoter:

Genomic Location for FCRL2 Gene

Chromosome:
1
Start:
157,745,733 bp from pter
End:
157,777,439 bp from pter
Size:
31,707 bases
Orientation:
Minus strand

Genomic View for FCRL2 Gene

Genes around FCRL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FCRL2 Gene

Proteins for FCRL2 Gene

Products:

  1. Antibody
  2. Protein
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  • Protein details for FCRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LA5-FCRL2_HUMAN
    Recommended name:
    Fc receptor-like protein 2
    Protein Accession:
    Q96LA5
    Secondary Accessions:
    • A0N0M5
    • A1L307
    • A6NMS0
    • Q6NTA1
    • Q9BZI4
    • Q9BZI5
    • Q9BZI6

    Protein attributes for FCRL2 Gene

    Size:
    508 amino acids
    Molecular mass:
    55542 Da
    Quaternary structure:
    • The tyrosine-phosphorylated isoform 2 interacts with PTPN6.

    Alternative splice isoforms for FCRL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCRL2 Gene

Protein Expression for FCRL2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FCRL2 Gene

  • Isoform 2 is N- and O-glycosylated, and phosphorylated.
  • Glycosylation at Asn204, isoforms=234, isoforms=2, 3, 4343, Asn355, and Asn365
  • Modification sites at PhosphoSitePlus

Other Protein References for FCRL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCRL2 Gene

Domains & Families for FCRL2 Gene

Gene Families for FCRL2 Gene

HGNC:

Protein Domains for FCRL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FCRL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LA5

UniProtKB/Swiss-Prot:

FCRL2_HUMAN :
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.
Domain:
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.
genes like me logo Genes that share domains with FCRL2: view

Function for FCRL2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FCRL2 Gene

UniProtKB/Swiss-Prot Function:
May have an regulatory role in normal and neoplastic B cell development.

Gene Ontology (GO) - Molecular Function for FCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IPI 11162587
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FCRL2: view
genes like me logo Genes that share phenotypes with FCRL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL2 Gene

Localization for FCRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11162587
genes like me logo Genes that share ontologies with FCRL2: view

Pathways & Interactions for FCRL2 Gene

SuperPathways for FCRL2 Gene

PathCards logo More details on SuperPathways for FCRL2
No Data Available

Gene Ontology (GO) - Biological Process for FCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling NAS 11162587
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with FCRL2: view

No data available for Pathways by source and SIGNOR curated interactions for FCRL2 Gene

Drugs & Compounds for FCRL2 Gene

Products:

  1. Drug

(1) Drugs for FCRL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FCRL2: view

Transcripts for FCRL2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FCRL2 Gene

(11) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCRL2 Gene

Fc receptor-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - - - - - - - -
SP5:
SP6: - - - - -

Relevant External Links for FCRL2 Gene

GeneLoc Exon Structure for
FCRL2
ECgene alternative splicing isoforms for
FCRL2

Expression for FCRL2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL2 Gene

mRNA expression in normal human tissues for FCRL2 Gene
mRNA expression by BioGPS for FCRL2 GenemRNA expression by GTEx for FCRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL2 Gene

This gene is overexpressed in Spleen (x24.8), Small Intestine - Terminal Ileum (x17.5), and Whole Blood (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of FCRL2 Gene:

FCRL2

SOURCE GeneReport for Unigene cluster for FCRL2 Gene:

Hs.437393

mRNA Expression by UniProt/SwissProt for FCRL2 Gene:

Q96LA5-FCRL2_HUMAN
Tissue specificity: Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).

Evidence on tissue expression from TISSUES for FCRL2 Gene

  • Lymph node(4.4)
genes like me logo Genes that share expression patterns with FCRL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL2 Gene

Orthologs for FCRL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FCRL2 34 35
  • 99.15 (n)
dog
(Canis familiaris)
 Mammalia FCRL2 34 35
  • 78.15 (n)
cow
(Bos Taurus)
 Mammalia FCRL2 35
  • 40 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fcrls 35
  • 38 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FCRL2 35
  • 27 (a)
 OneToMany
Species where no ortholog for FCRL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL2 Gene

ENSEMBL:
Gene Tree for FCRL2 (if available)
TreeFam:
Gene Tree for FCRL2 (if available)

Paralogs for FCRL2 Gene

Paralogs for FCRL2 Gene

(6) SIMAP similar genes for FCRL2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FCRL2 Gene

genes like me logo Genes that share paralogs with FCRL2: view

Variants for FCRL2 Gene

Sequence variations from dbSNP and Humsavar for FCRL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000119805 -- 157,754,053(+) TACCT(A/G)TTGAA intron-variant
rs1000166808 -- 157,755,817(+) ATGAC(A/T)TCACA intron-variant
rs1000193249 -- 157,753,848(+) TCAAC(A/C)CTCAA intron-variant
rs1000392734 -- 157,764,614(+) ATCAT(A/G)TCAAG intron-variant
rs1000420311 -- 157,747,626(+) TGTCA(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL2 Gene

Variant ID Type Subtype PubMed ID
nsv946434 CNV duplication 23825009

Variation tolerance for FCRL2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCRL2 Gene

Human Gene Mutation Database (HGMD)
FCRL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCRL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL2 Gene

Disorders for FCRL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCRL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search FCRL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCRL2

Genetic Association Database (GAD)
FCRL2
Human Genome Epidemiology (HuGE) Navigator
FCRL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCRL2
genes like me logo Genes that share disorders with FCRL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCRL2 Gene

Publications for FCRL2 Gene

  1. Molecular cloning and characterization of SPAP1, an inhibitory receptor. (PMID: 11162587) Xu M.-J. … Zhao Z.J. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (PMID: 16849395) Polson A.G. … Ebens A. (Int. Immunol. 2006) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FCRL2 Gene

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