Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FCRL1 Gene

Aliases for FCRL1 Gene

  • Fc Receptor Like 1 2 3 5
  • Immune Receptor Translocation-Associated Protein 5 3 4
  • Fc Receptor Homolog 1 3 4
  • IFGP Family Protein 1 3 4
  • FcR-Like Protein 1 3 4
  • HIFGP1 3 4
  • FCRH1 3 4
  • IFGP1 3 4
  • IRTA5 3 4
  • Immunoglobulin Superfamily Fc Receptor, Gp42 3
  • Fc Receptor-Like Protein 1 3
  • Fc Receptor-Like 1 2
  • CD307a Antigen 4
  • CD307a 3
  • FcRL1 4

External Ids for FCRL1 Gene

Previous GeneCards Identifiers for FCRL1 Gene

  • GC01M154579
  • GC01M156030
  • GC01M129122

Summaries for FCRL1 Gene

Entrez Gene Summary for FCRL1 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCRL1 Gene

FCRL1 (Fc Receptor Like 1) is a Protein Coding gene. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCRL1 Gene

  • May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.

Gene Wiki entry for FCRL1 Gene

Additional gene information for FCRL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL1 Gene

Genomics for FCRL1 Gene

Regulatory Elements for FCRL1 Gene

Enhancers for FCRL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H157721 1.2 Ensembl ENCODE dbSUPER 10 +95.7 95717 6.4 NR2F1 ZBTB7B RELA GABPA ZNF585B IKZF1 NBN RUNX3 IKZF2 SPI1 FCRL3 ENSG00000227217 FCRL2 FCRL1 VDAC1P9 SONP1
GH01H157510 1.1 ENCODE dbSUPER 9.3 +308.1 308130 2.5 HDGF PKNOX1 TBL1XR1 BACH1 RBBP5 BMI1 BATF EED ATF7 ETV6 FCRL5 PRCC FCRL1 PIR33564
GH01H157773 0.6 ENCODE 15.5 +46.0 45959 1.5 CTCF TARDBP TRIM22 NBN SMC3 RAD21 SPI1 FCRL3 FCRL1 FCRL5 FCRL2 PIR43091
GH01H157595 0.8 ENCODE 9.5 +224.6 224615 0.1 TBL1XR1 BMI1 BATF POLR2A EED ATF7 ETV6 RUNX3 IKZF2 CREM FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4
GH01H157733 0.6 ENCODE dbSUPER 10.2 +85.6 85575 2.1 RUNX3 FCRL3 FCRL2 ENSG00000227217 FCRL1 VDAC1P9 PIR43091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCRL1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FCRL1 Gene

Genomic Locations for FCRL1 Gene
27,902 bases
Minus strand

Genomic View for FCRL1 Gene

Genes around FCRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL1 Gene

Proteins for FCRL1 Gene

  • Protein details for FCRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RE05
    • Q8N759
    • Q8NDI0
    • Q96PJ6

    Protein attributes for FCRL1 Gene

    429 amino acids
    Molecular mass:
    46936 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRL1 Gene


neXtProt entry for FCRL1 Gene

Post-translational modifications for FCRL1 Gene

No data available for DME Specific Peptides for FCRL1 Gene

Domains & Families for FCRL1 Gene

Gene Families for FCRL1 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCRL1 Gene

Suggested Antigen Peptide Sequences for FCRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCRL1: view

No data available for UniProtKB/Swiss-Prot for FCRL1 Gene

Function for FCRL1 Gene

Molecular function for FCRL1 Gene

UniProtKB/Swiss-Prot Function:
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in activated B-cells.
genes like me logo Genes that share phenotypes with FCRL1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL1 Gene

Localization for FCRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCRL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRL1 Gene

Pathways & Interactions for FCRL1 Gene

SuperPathways for FCRL1 Gene

No Data Available

Interacting Proteins for FCRL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96LA6-FCRL1_HUMAN ENSP00000357158 for FCRL1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FCRL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FCRL1 Gene

Drugs & Compounds for FCRL1 Gene

No Compound Related Data Available

Transcripts for FCRL1 Gene

Unigene Clusters for FCRL1 Gene

Fc receptor-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -

Relevant External Links for FCRL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL1 Gene

This gene is overexpressed in Spleen (x22.5), Small Intestine - Terminal Ileum (x13.5), and Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for FCRL1 Gene

This gene is overexpressed in Testis (32.2), Heart (28.6), and Blymphocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCRL1 Gene

Protein tissue co-expression partners for FCRL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCRL1 Gene:


SOURCE GeneReport for Unigene cluster for FCRL1 Gene:


mRNA Expression by UniProt/SwissProt for FCRL1 Gene:

Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).

Evidence on tissue expression from TISSUES for FCRL1 Gene

  • Lymph node(4.5)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with FCRL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL1 Gene

Orthologs for FCRL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCRL1 34 33
  • 99.07 (n)
(Bos Taurus)
Mammalia FCRL1 34 33
  • 76.52 (n)
(Mus musculus)
Mammalia Fcrl1 34 16 33
  • 75.16 (n)
(Canis familiaris)
Mammalia FCRL1 34 33
  • 72.82 (n)
(Gallus gallus)
Aves FCRL2 34
  • 21 (a)
Species where no ortholog for FCRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL1 Gene

Gene Tree for FCRL1 (if available)
Gene Tree for FCRL1 (if available)

Paralogs for FCRL1 Gene

(4) SIMAP similar genes for FCRL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FCRL1: view

Variants for FCRL1 Gene

Sequence variations from dbSNP and Humsavar for FCRL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000044448 -- 157,793,340(+) AAAAA(A/T)GTCCA nc-transcript-variant, utr-variant-3-prime
rs1000133381 -- 157,816,348(+) AAACC(A/G)CATGA intron-variant
rs1000143651 -- 157,808,106(+) AAAAT(A/C)ATATT intron-variant, utr-variant-5-prime
rs1000202142 -- 157,794,231(+) AAAAC(-/TG)TAAGA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000522244 -- 157,811,776(+) TAGTA(C/T)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL1 Gene

Variant ID Type Subtype PubMed ID
esv3587657 CNV loss 21293372
esv3371841 CNV duplication 20981092

Variation tolerance for FCRL1 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCRL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL1 Gene

Disorders for FCRL1 Gene

Relevant External Links for FCRL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FCRL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCRL1 Gene

Publications for FCRL1 Gene

  1. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PMID: 11929751) Miller I … Dalla-Favera R (Blood 2002) 2 3 4 60
  2. Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis RS … Cooper MD (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. (PMID: 17895404) Du X … Pastan I (Blood 2008) 3 22 60
  5. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (PMID: 16849395) Polson AG … Ebens A (International immunology 2006) 3 4 60

Products for FCRL1 Gene

Sources for FCRL1 Gene

Loading form....