FCRL1 Gene
protein-coding GIFtS: 47
GCID: GC01M157764
|
|
Fc receptor-like 1
| |
Aliases
for FCRL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fc Receptor-Like 11 2 | | HIFGP11 | | FCRH11 2 3 5 | | IFGP Family Protein 12 3 | | IFGP11 2 3 | | Fc Receptor-Like Protein 12 | | IRTA51 2 3 | | Immunoglobulin Superfamily Fc Receptor, Gp422 | | CD307a1 2 | | FcRH13 | | Fc Receptor Homolog 12 3 | | FcRL13 | | FcR-Like Protein 12 3 | | CD307a Antigen3 | | Immune Receptor Translocation-Associated Protein 52 3 | | |
Export aliases for FCRL1 gene to outside databasesPrevious GC identifers: GC01M154579 GC01M156030 GC01M129122 |
Summaries
for FCRL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FCRL1:
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-likeglycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-likeimmunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activationmotifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: FCRL1_HUMAN, Q96LA6Function: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation
Gene Wiki entry for FCRL1
|
Genomic Views
for FCRL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCRL1 gene promoter:
RP58 USF1 AP-1 AML1a AP-4 Evi-1 RORalpha1 Max USF-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCRL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCRL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21-q22FCRL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M157764: view genomic region
(about GC identifiers)
Start:
|
157,764,193 bp from pter |
End:
|
157,789,940 bp from pter |
Size:
|
25,748 bases |
Orientation:
|
minus strand |
|
Proteins
for FCRL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCRL1_HUMAN, Q96LA6 (See
protein sequence)Recommended Name: Fc receptor-like protein 1 precursor Size: 429 amino acids; 46936 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: B2RE05 Q8N759 Q8NDI0 Q96PJ6Alternative splicing: 4 isoforms: Q96LA6-1 Q96LA6-2 Q96LA6-3 Q96LA6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FCRL1: NX_Q96LA6
Post-translational modifications:
Phosphorylated on tyrosines upon activation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96LA6
FCRL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001152869.1 NP_001152870.1 NP_443170.1
ENSEMBL proteins: ENSP00000351039 ENSP00000357158 ENSP00000418130
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FCRL1 for ontologies About GeneDecksing
FCRL1 Antibody Products:
Assay Products for FCRL1: |
Protein
Domains /
Families
for FCRL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCRL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96LA6ProtoNet protein and cluster: Q96LA6 UniProtKB/Swiss-Prot: FCRL1_HUMAN, Q96LA6Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains |
Function
for FCRL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FCRL1_HUMAN, Q96LA6Function: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiationInduction: Down-regulated in activated B-cells
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL1 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
FCRL1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Fcrl1tm1Lex for FCRL1
1 MGI phenotypic allele  for Fcrl1 (no phenotypes)
FCRL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FCRL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCRL1
|
Drugs & Compounds
for FCRL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FCRL1
Search CenterWatch for drugs/clinical trials and news about FCRL1
|
Transcripts
for FCRL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCRL1 gene (3 alternative transcripts): NM_001159397.1 NM_001159398.1 NM_052938.4 Unigene Cluster for FCRL1: Fc receptor-like 1 Hs.656112 [show with all ESTs]Unigene Representative Sequence: NM_0529388 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000463001(uc001frf.3) ENST00000358292(uc001frh.3 uc001frg.3 uc001fri.3 uc001frj.3)
ENST00000489998 ENST00000368175 ENST00000368176 ENST00000495126 ENST00000491942
ENST00000480310
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCRL1 (see all 3)
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Additional cDNA sequence: AF329488.1 AF459634.1 AK096690.1 AK315748.1 AL833674.1 AL833970.1 AY043464.1 BC021274.2 BC033690.1 6 DOTS entries: DT.311895 DT.40196801 DT.40201708 DT.100021758 DT.95370220 DT.100721783 24/51 AceView cDNA sequences (see all 51): AI572979 AA804243 NM_052938 BC021274 AF459634 AA766150 CB956381 AA810016 AA769152 AA278822 AY043464 BC033690 AL833674 AK096690 AA767265 AA813919 AI419925 AW294948 AA505047 AW198126 BP338112 AA279424 BG758135 AF329488
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FCRL1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | |
ECgene alternative splicing isoforms for FCRL1
|
Expression
for FCRL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCRL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACCAAACT
About this image
See FCRL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCRL1
SOURCE GeneReport for Unigene cluster: Hs.656112
UniProtKB/Swiss-Prot: FCRL1_HUMAN, Q96LA6Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen,lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells withhigher expression in naive versus memory B-cells (at protein level)
SABiosciences Custom PCR Arrays for FCRL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCRL1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCRL1 |
Orthologs
for FCRL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FCRL1 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
-- |
16(a) |
1 → many |
25(1707231-1709870) |
ENSEMBL Gene Tree for FCRL1 (if available)
TreeFam Gene Tree for FCRL1 (if available) |
Paralogs
for FCRL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCRL1 gene
- FCGR2B2 FCGR1B2 FCGR3B2 FCRL22 FCRLB2 FCRL42 FCRL52 FCRLA2
- FCGR1A2 FCGR2A2 FCGR3A2 FCRL32 FCER1A2 FCRL62
4 SIMAP similar genes for FCRL1 using alignment to 1 protein entry: FCRL1_HUMAN:FCRL2 FCRL3 FCRL5 FLJ00333
FCRL1 for paralogs About GeneDecksing
|
Genomic Variants
for FCRL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCRL1 (157764193 - 157789940 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FCRL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCRL1 |
|
Disorders
/ Diseases
for FCRL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCRL1 for disorders About GeneDecksing
OMIM gene information: 606508
OMIM disorders: --
12  diseases for FCRL1: About MalaCardsb-cell non-hodgkin lymphoma non-hodgkin lymphoma hodgkin's lymphoma hairy cell leukemia
acute lymphoblastic leukemia chronic lymphocytic leukemia lymphoblastic leukemia lymphocytic leukemia
t-cell leukemia leukemia hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: FCRL1 (2 documents)
Export disorders for FCRL1 gene to outside databases
|
Publications
for FCRL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCRL1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with FCRL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PubMed id 11929751)1, 2, 3 Miller I....Dalla-Favera R. (2002)
- Identification of a family of Fc receptor homologs with preferential B cell expression. (PubMed id 11493702)1, 2, 3 Davis R.S....Cooper M.D. (2001)
- Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (PubMed id 16849395)1, 2 Polson A.G.... Ebens A. (2006)
- FcRH1: an activation coreceptor on human B cells. (PubMed id 15479727)1, 2 Leu C.M....Cooper M.D. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1. (PubMed id 12037601)1, 2 Guselnikov S.V.... Taranin A.V. (2002)
- FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. (PubMed id 17895404)1, 9 Du X....Pastan I. (2008)
- [Expression of human B-cell specific receptor FCRL1 in normal individuals and in patients with autoimmune diseases]. (PubMed id 22888639)1 Baranov K.O....Naiakshin A.M. (2012)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for FCRL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCRL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCRL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCRL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCRL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCRL1 gene:
Search GeneIP for patents involving FCRL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCRL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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