Aliases for FCRL1 Gene
Aliases for FCRL1 Gene
External Ids for FCRL1 Gene
- HGNC: 18509
- Entrez Gene: 115350
- Ensembl: ENSG00000163534
- OMIM: 606508
- UniProtKB: Q96LA6
Previous GeneCards Identifiers for FCRL1 Gene
- GC01M154579
- GC01M156030
- GC01M129122
Summaries for FCRL1 Gene
-
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
GeneCards Summary for FCRL1 Gene
FCRL1 (Fc Receptor Like 1) is a Protein Coding gene. An important paralog of this gene is FCRL2.
UniProtKB/Swiss-Prot for FCRL1 Gene
-
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL1 Gene
Genomics for FCRL1 Gene
Regulatory Elements for FCRL1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G157721 | 1.2 | Ensembl ENCODE dbSUPER | 10 | +95.7 | 95717 | 6.4 | CTCF ZBTB7B RAD21 RELA GATA3 POLR2A SMC3 RELB IKZF2 ZNF654 | FCRL3 ENSG00000227217 FCRL2 FCRL1 VDAC1P9 SONP1 |
| GH01G157510 | 1.1 | ENCODE dbSUPER | 9.3 | +308.1 | 308130 | 2.5 | HDGF PKNOX1 TBL1XR1 BMI1 ZBTB40 RELB ETV6 IKZF2 CREM EGR2 | FCRL5 FCRL1 PIR33564 |
| GH01G157773 | 0.6 | ENCODE | 15.5 | +46.0 | 45959 | 1.5 | CTCF TARDBP TRIM22 NBN SMC3 RAD21 SPI1 | FCRL3 FCRL1 FCRL5 FCRL2 PIR43091 |
| GH01G157595 | 0.8 | ENCODE | 9.5 | +224.6 | 224615 | 0.1 | TBL1XR1 WRNIP1 BMI1 CBX5 EED ETV6 RELB IKZF2 CREM CHD2 | FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4 |
| GH01G157733 | 0.7 | ENCODE dbSUPER | 10.2 | +85.6 | 85575 | 2.1 | PKNOX1 TBX21 | FCRL3 FCRL2 ENSG00000227217 FCRL1 VDAC1P9 PIR43091 |
Regulatory Element Products
Genomic Location for FCRL1 Gene
- Chromosome:
- 1
- Start:
- 157,792,249 bp from pter
- End:
- 157,820,150 bp from pter
- Size:
- 27,902 bases
- Orientation:
- Minus strand
Genomic View for FCRL1 Gene
- Cytogenetic band:
-
- 1q23.1 by Ensembl
- 1q23.1 by Entrez Gene
- 1q23.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCRL1 Gene
Proteins for FCRL1 Gene
-
Protein details for FCRL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96LA6-FCRL1_HUMAN
- Recommended name:
- Fc receptor-like protein 1
- Protein Accession:
- Q96LA6
- B2RE05
- Q8N759
- Q8NDI0
- Q96PJ6
Protein attributes for FCRL1 Gene
- Size:
- 429 amino acids
- Molecular mass:
- 46936 Da
- Quaternary structure:
- No Data Available
Protein Expression for FCRL1 Gene
Post-translational modifications for FCRL1 Gene
- Phosphorylated on tyrosines upon activation.
- Glycosylation at Asn293
- Modification sites at PhosphoSitePlus
Other Protein References for FCRL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FCRL1 (FCRL1/FcRH1)
- Novus Biologicals Antibodies for FCRL1
-
Abcam antibodies for FCRL1
- Invitrogen Antibodies for FCRL1
- antibodies-online Antibodies for FCRL1: See all 4
- Search GeneTex for Antibodies for FCRL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FCRL1
Protein Products
- R&D Systems Proteins and Enzymes for FCRL1 (FCRL1/FcRH1)
-
OriGene Purified Proteins for FCRL1
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- Sino Biological Cell Lysates for FCRL1
- Search GeneTex for Proteins for FCRL1
-
ProSci Proteins for FCRL1
-
Abcam proteins for FCRL1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for FCRL1 (FCRL1/FcRH1)
No data available for DME Specific Peptides for FCRL1 Gene
Domains & Families for FCRL1 Gene
Gene Families for FCRL1 Gene
Protein Domains for FCRL1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCRL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCRL1 Gene
Function for FCRL1 Gene
Molecular function for FCRL1 Gene
- UniProtKB/Swiss-Prot Function:
- May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in activated B-cells.
Phenotypes for FCRL1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for FCRL1
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL1 gene
- Search ViGene Biosciences for FCRL1
CRISPR Products
-
OriGene CRISPR knockouts for FCRL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRL1
- GenScript: Design CRISPR guide RNA sequences for FCRL1
miRNA Products
- Search ViGene Biosciences for FCRL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCRL1
- Browse OriGene Inhibitory RNA Products For FCRL1
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL1 gene
Clone Products
- Sino Biological Human cDNA Clone for FCRL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for FCRL1 (FCRL1/FcRH1)
Cell Line Products
-
Horizon Cell Lines for FCRL1
-
ViGene Biosciences adenoviral particle packaged cDNA for FCRL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCRL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL1 Gene
Localization for FCRL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCRL1 Gene
- Cell membrane; Single-pass type I membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for FCRL1 Gene
No data available for Pathways by source and SIGNOR curated interactions for FCRL1 Gene
Transcripts for FCRL1 Gene
mRNA/cDNA for FCRL1 Gene
- (20) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FCRL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCRL1
- GenScript: Design CRISPR guide RNA sequences for FCRL1
miRNA Products
- Search ViGene Biosciences for FCRL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCRL1
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-
ViGene Biosciences ready-to-package AAV shRNAs for FCRL1 gene
Clone Products
- Sino Biological Human cDNA Clone for FCRL1
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- R&D Systems cDNA Clones for FCRL1 (FCRL1/FcRH1)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||
| SP7: |
Expression for FCRL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Mature B-Cells Peripheral Blood
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for FCRL1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCRL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FCRL1 Gene:
FCRL1SOURCE GeneReport for Unigene cluster for FCRL1 Gene:
Hs.656112mRNA Expression by UniProt/SwissProt for FCRL1 Gene:
Q96LA6-FCRL1_HUMANEvidence on tissue expression from TISSUES for FCRL1 Gene
- Lymph node(4.5)
- Blood(4.2)
Primer Products
-
OriGene qPCR primer pairs for FCRL1
-
OriGene qPCR primer pairs and template standards for FCRL1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL1 Gene
Orthologs for FCRL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCRL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCRL1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcrl1 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCRL1 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | FCRL2 35 |
|
OneToMany |
- Species where no ortholog for FCRL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCRL1 Gene
Paralogs for FCRL1 Gene
(4) SIMAP similar genes for FCRL1 Gene using alignment to 1 proteins:
Variants for FCRL1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000044448 | -- | 157,793,340(+) | AAAAA(A/T)GTCCA | nc-transcript-variant, utr-variant-3-prime | |
| rs1000133381 | -- | 157,816,348(+) | AAACC(A/G)CATGA | intron-variant | |
| rs1000143651 | -- | 157,808,106(+) | AAAAT(A/C)ATATT | intron-variant, utr-variant-5-prime | |
| rs1000202142 | -- | 157,794,231(+) | AAAAC(-/TG)TAAGA | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1000522244 | -- | 157,811,776(+) | TAGTA(C/T)ACCAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3371841 | CNV | duplication | 20981092 |
| esv3587657 | CNV | loss | 21293372 |
Relevant External Links for FCRL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCRL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL1 Gene
Disorders for FCRL1 Gene
Relevant External Links for FCRL1
No disorders were found for FCRL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCRL1 Gene
Publications for FCRL1 Gene
- IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells. (PMID: 11929751) Miller I. … Dalla-Favera R. (Blood 2002) 2 3 4 64
- Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis R.S. … Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. (PMID: 17895404) Du X. … Pastan I. (Blood 2008) 3 22 64
- Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (PMID: 16849395) Polson A.G. … Ebens A. (Int. Immunol. 2006) 3 4 64
Products for FCRL1 Gene
- R&D Systems Antibodies for FCRL1 (FCRL1/FcRH1)
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- OriGene qPCR primer pairs and template standards for FCRL1
- OriGene qPCR primer pairs for FCRL1
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- GenScript: Design CRISPR guide RNA sequences for FCRL1
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- Novus Biologicals Antibodies for FCRL1
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- Abcam antibodies for FCRL1
- Abcam proteins for FCRL1
- Search for Assays for FCRL1 at Abcam
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- Taconic Biosciences Mouse Models for FCRL1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for FCRL1 gene
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- Search ViGene Biosciences for FCRL1
- Santa Cruz Biotechnology (SCBT) Antibodies for FCRL1
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- Horizon Cell Lines for FCRL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCRL1
- VectorBuilder custom plasmid, inducible vectors for FCRL1
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCRL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




