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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCN3 Gene

protein-coding   GIFtS: 63
GCID: GC01M027695

Ficolin (Collagen/Fibrinogen Domain Containing) 3

(Previous name: ficolin (collagen/fibrinogen domain-containing) 3 (Hakata...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ficolin (Collagen/Fibrinogen Domain Containing) 31 2     Ficolin (Collagen/Fibrinogen Domain-Containing) 3 (Hakata Antigen)1
HAKA12 3 5     H-ficolin2
Hakata Antigen1 3     Ficolin (Collagen/Fibrinogen Domain Containing) 3 (Hakata Antigen)2
Collagen/Fibrinogen Domain-Containing Lectin 3 P352 3     Ficolin 32
Collagen/Fibrinogen Domain-Containing Protein 32 3     ficolin-32
FCNH2 3     

External Ids:    HGNC: 36251   Entrez Gene: 85472   Ensembl: ENSG000001427487   OMIM: 6049735   UniProtKB: O756363   

Export aliases for FCN3 gene to outside databases

Previous GC identifers: GC01P027890 GC01M026727 GC01M026928 GC01M027300 GC01M027379 GC01M027568 GC01M025951


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCN3 Gene:
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human
serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a
thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin
family. The protein, which was initially identified based on its reactivity with sera from patients with systemic
lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the
complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of
the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform,
have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FCN3 Gene: 
FCN3 (ficolin (collagen/fibrinogen domain containing) 3) is a protein-coding gene. Diseases associated with FCN3 include immunodeficiency due to ficolin3 deficiency, and rheumatic fever, and among its related super-pathways are Immune response Alternative complement pathway and Classical antibody-mediated complement activation. GO annotations related to this gene include carbohydrate binding and receptor binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and
lipopolysaccharides from S.typhimurium and S.minnesota

Gene Wiki entry for FCN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCN3 gene promoter:
         Elk-1   NRSF form 1   STAT5A   NRSF form 2   Ik-3   E2F   E2F-1   HOXA5   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FCN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

FCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCN3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027695:  view genomic region     (about GC identifiers)

Start:
27,695,601 bp from pter      End:
27,701,315 bp from pter
Size:
5,715 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636 (See protein sequence)
Recommended Name: Ficolin-3 precursor  
Size: 299 amino acids; 32903 Da
Subunit: Homopolymer; disulfide-linked. May be an octadecamer consisting of an elementary trimer unit. Does not
interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2
Subcellular location: Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct
4 PDB 3D structures from and Proteopedia for FCN3:
1LA5 (3D)        2J5Z (3D)        2J60 (3D)        2J64 (3D)    
Secondary accessions: Q6IBJ5 Q8WW86
Alternative splicing: 2 isoforms:  O75636-1   O75636-2   

Explore the universe of human proteins at neXtProt for FCN3: NX_O75636

Explore proteomics data for FCN3 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75636

  • FCN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FCN3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003656.2  NP_775628.1  

    ENSEMBL proteins: 
     ENSP00000270879   ENSP00000347077  
    Reactome Protein details: O75636
    Human Recombinant Protein Products for FCN3: 
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    Novus Biologicals FCN3 Protein
    Novus Biologicals FCN3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FCN3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--

    FCN3 for ontologies           About GeneDecksing



    FCN3 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for FCN3 

    Assay Products for FCN3: 
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    Cloud-Clone Corp. ELISAs for FCN3 
    Cloud-Clone Corp. CLIAs for FCN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry O75636

    ProtoNet protein and cluster: O75636

    2 Blocks protein domains:
    IPB002181 Fibrinogen
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
    Similarity: Belongs to the ficolin lectin family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 fibrinogen C-terminal domain


    FCN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCN3_HUMAN, O75636
    Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
    and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and
    lipopolysaccharides from S.typhimurium and S.minnesota

         Genatlas biochemistry entry for FCN3:
    ficolin 3 (collagen/fibrinogen domain-containing),TGF1 binding protein,Hakata antigen,present in the serum as
    homopolymers,reactin with the serum from patients with systemic lupus erythromatous,expressed in the
    lung,produced by both ciliated bronchial epithelial cells and Type II alveolar epithelial cells and was secreted
    into the bronchus and alveolus,also expressed in liver,Hakata antigen is produced by bile duct epithelial cells
    and hepatocytes and secreted into the bile duct

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11907111
    GO:0030246carbohydrate binding TAS9694814
         
    FCN3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FCN3:
     Synthetic lethal with imatinib 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCN3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FCN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Lectin Induced complement pathway0.56
    2Classical antibody-mediated complement activation
    Creation of C4 and C2 activators0.88
    Complement cascade0.76
    Initial triggering of complement0.86
    3Ficolins bind to repetitive carbohydrate structures on the target cell surface
    Ficolins bind to repetitive carbohydrate structures on the target cell surface0.83
    Lectin pathway of complement activation0.83
    4Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FCN3
        Immune response Lectin Induced complement pathway


    1 GeneGo (Thomson Reuters) Pathway for FCN3
        Immune response Lectin induced complement pathway

    5/7        Reactome Pathways for FCN3 (see all 7)
        Creation of C4 and C2 activators
    Ficolins bind to repetitive carbohydrate structures on the target cell surface
    Lectin pathway of complement activation
    Complement cascade
    Immune System



    FCN3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCN3

    1 Interacting protein for FCN3 (O756363) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTX3P260223I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001867complement activation, lectin pathway TAS--
    GO:0006956complement activation TAS--
    GO:0045087innate immune response TAS--

    FCN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCN3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCN3

    3 Novoseek inferred chemical compound relationships for FCN3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 64.8 8 19699205 (1), 16305643 (1), 16644773 (1), 15950722 (1) (see all 8)
    mannan 64 3 17303612 (1), 19234189 (1)
    polysaccharide 24.9 1 11907111 (1)

    Search CenterWatch for drugs/clinical trials and news about FCN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCN3 gene (2 alternative transcripts): 
    NM_003665.2  NM_173452.1  

    Unigene Cluster for FCN3:

    Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
    Hs.333383  [show with all ESTs]
    Unigene Representative Sequence: AL557853
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270879(uc001boa.3) ENST00000354982(uc001bob.3) ENST00000498393
    ENST00000481748
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCN3

    Additional mRNA sequence: 

    AK075140.1 AK309540.1 AK309576.1 AY358081.1 AY358283.1 BC020731.1 CR456808.1 

    4 DOTS entries:

    DT.95113865  DT.441573  DT.91869506  DT.121386911 

    24/81 AceView cDNA sequences (see all 81):

    AA298470 CR604997 AK075140 BM971320 NM_173452 AA345852 NM_003665 BM985127 
    AV653375 BM725707 AI589209 AL557854 BM313732 BU681042 CR456808 AY358081 
    BX350307 BG546674 BM924811 AY358283 T92148 AI364974 AI346745 BU680746 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FCN3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                    -           -                                 
    SP2:                    -           -     -                           
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for FCN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCN3 expression in normal human tissues (normalized intensities)      FCN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACCGAGG
    FCN3 Expression
    About this image


    FCN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             PureStem endothelial progenitor 30-MV2-12
             Fetal Liver CD34+ Cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             PureStem ES-335, Meso-latp Progenitor
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
     
     Adrenal Gland (Endocrine System)
             adrenal cortex   
     
     Lung (Respiratory System)

    See FCN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCN3

    SOURCE GeneReport for Unigene cluster: Hs.333383

    UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
    Tissue specificity: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung
    it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for FCN3 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia FCN36
    ficolin (collagen/fibrinogen domain containing) 3 ...
    49(a)
    1 ↔ 1
    4(364958428-364968842)


    ENSEMBL Gene Tree for FCN3 (if available)
    TreeFam Gene Tree for FCN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCN3 gene
    FGL22  ANGPT42  FIBCD12  ANGPTL62  ANGPTL22  FCN22  FCN12  ANGPT12  
    ANGPTL12  ANGPTL72  ANGPT22  MFAP42  
    18/27 SIMAP similar genes for FCN3 using alignment to 3 protein entries:     FCN3_HUMAN (see all proteins) (see all similar genes):
    ANGPTL2    TNR    ANGPT4    TNC    ANGPTL3    TNC variant protein
    FCN1    ANGPT2    ANGPTL7    FCN2    ANGPT1    TNN
    FIBCD1    TNXB    MFAP4    FGL1    ANGPTL1    FGL2

    FCN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/232 SNPs in FCN3 are shown (see all 232)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283628071,2
    C,F--25953927(-) AGCGT-/GGC   
      CAAATA
    TCTTG
    2 -- cds13Minor allele frequency- GGCCAAATA:0.37NS CSA 96
    rs675080141,2
    C--25953928(+) AAGAA-/T/TATC/
    TATTTGGCC
    CGCTT
    4 -- int1 cds10--------
    rs345600381,2
    C,F--27696501(+) TTTTT-/TCTGAG 2 -- int13Minor allele frequency- T:0.33NA CSA 6
    rs283856491,2
    C,F--27699266(-) AAAAAA/TATAGG 2 -- int1 trp33Minor allele frequency- T:0.02NS NA 96
    rs283570921,2
    C,F--27699671(-) CAGGGC/-CCTCC 4 /S /L fra12Minor allele frequency- -:0.02NS 94
    rs283857281,2
    C,F--27914546(-) GGCTGG/AAGTGC 2 -- ds50013Minor allele frequency- A:0.07NS CSA 96
    rs1125023611,2
    F--27914778(+) AGGCTC/GTCCTT 2 -- ds50011Minor allele frequency- G:0.40CSA 5
    rs2022306641,2
    C--27915026(+) CATCCA/GAACCC 4 R W mis10--------
    rs558631541,2
    C,F--27915049(-) TGGTGT/CGGGCC 4 /A /V mis11Minor allele frequency- C:0.00NA 4550
    rs342954871,2
    C--27915059(+) ACGGCC/TTGAGG 4 S G mis11Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for FCN3 (27695601 - 27701315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FCN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1006916CNV Deletion20482838
    nsv516766CNV Loss19592680
    nsv870665CNV Loss21882294
    dgv204n71CNV Loss21882294
    dgv203n71CNV Loss21882294
    nsv526051CNV Gain19592680


    Human Gene Mutation Database (HGMD): FCN3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FCN3
    DNA2.0 Custom Variant and Variant Library Synthesis for FCN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604973    OMIM disorders: --

    UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
  • Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent
    infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of
    lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to
    pneumococcal polysaccharide vaccine. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 20/21 diseases for FCN3 (see all 21):    About MalaCards
    immunodeficiency due to ficolin3 deficiency    rheumatic fever    systemic lupus erythematosus    lupus erythematosus
    gout    proliferative diabetic retinopathy    diabetic retinopathy    hepatoblastoma
    neutropenia    sarcoidosis    crohn's disease    pre-eclampsia
    eclampsia    essential hypertension    hepatitis b    influenza
    rheumatoid arthritis    arthritis    hepatocellular carcinoma    hepatitis

    1 disease from the University of Copenhagen DISEASES database for FCN3:
    Autistic disorder

    FCN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FCN3
    Human Genome Epidemiology (HuGE) Navigator: FCN3 (4 documents)

    Export disorders for FCN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCN3 gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with FCN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. (PubMed id 10330454)1, 2, 3 Akaiwa M....Hamasaki N. (1999)
    2. Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. (PubMed id 9694814)1, 2, 3 Sugimoto R.... Hamasaki N. (1998)
    3. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). (PubMed id 11907111)1, 2, 9 Matsushita M....Fujita T. (2002)
    4. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PubMed id 19220833)1, 4, 9 Ruskamp J.M....Sanders E.A. (2009)
    5. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PubMed id 18032536)1, 4, 9 Vander Cruyssen B....De Keyser F. (2007)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state. (PubMed id 18261799)1, 9 Munthe-Fog L....Garred P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8547 HGNC: 3625 AceView: FCN3 Ensembl:ENSG00000142748 euGenes: HUgn8547
    ECgene: FCN3 H-InvDB: FCN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCN3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/fcn3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCN3 gene:
    Search GeneIP for patents involving FCN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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