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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FCN3 Gene

protein-coding GIFtS: 62
GCID: GC01M027695

ficolin (collagen/fibrinogen domain containing) 3 (Hakata...

(Previous name: ficolin (collagen/fibrinogen domain-containing) 3 (Hakata...)

Explore 17 diseases affiliated with
FCN3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ficolin (Collagen/Fibrinogen Domain Containing) 3 (Hakata Antigen)¹ ²		Ficolin (Collagen/Fibrinogen Domain-Containing) 3 (Hakata Antigen)¹
HAKA1¹ ² ³ ⁵		H-Ficolin¹
FCNH¹ ² ³		Ficolin 3²
Collagen/Fibrinogen Domain-Containing Lectin 3 P35² ³		Ficolin-3¹
Collagen/Fibrinogen Domain-Containing Protein 3² ³		Hakata Antigen³

External Ids:	HGNC: 3625¹	Entrez Gene: 8547²	Ensembl: ENSG00000142748⁷	OMIM: 604973⁵	UniProtKB: O75636³

Export aliases for FCN3 gene to outside databases

Previous GC identifers: GC01P027890 GC01M026727 GC01M026928 GC01M027300 GC01M027379 GC01M027568 GC01M025951

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCN3:

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum,

there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a

thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin

family. The protein, which was initially identified based on its reactivity with sera from patients with systemic

lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the

complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the

lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have

been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636

Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and

GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides

from S.typhimurium and S.minnesota

Gene Wiki entry for FCN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FCN3 gene promoter:
Elk-1 NRSF form 1 STAT5A NRSF form 2 Ik-3 E2F E2F-1 HOXA5 NF-kappaB1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCN3 promoter sequence

Search SABiosciences Chromatin IP Primers for FCN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11

FCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCN3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M027695: view genomic region (about GC identifiers)

Start:	27,695,601 bp from pter	End:	27,701,315 bp from pter
Size:	5,715 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636 (See protein sequence)

Recommended Name: Ficolin-3 precursor

Size: 299 amino acids; 32903 Da

Subunit: Homopolymer; disulfide-linked. May be an octadecamer consisting of an elementary trimer unit. Does not

interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2

Subcellular location: Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct

4 PDB 3D structures from and Proteopedia for FCN3:

1LA5 (3D)

2J5Z (3D)

2J60 (3D)

2J64 (3D)

Secondary accessions: Q6IBJ5 Q8WW86

Alternative splicing: 2 isoforms: O75636-1 O75636-2

Explore the universe of human proteins at neXtProt for FCN3: NX_O75636

Post-translational modifications:

The N-terminus is blocked¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75636

FCN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003656.2 NP_775628.1

ENSEMBL proteins:

ENSP00000270879 ENSP00000347077 ENSP00000420809

Human Recombinant Protein Products for FCN3:

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	Novus Biologicals FCN3 Protein Novus Biologicals FCN3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FCN3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005581	collagen	IEA	--
GO:0005615	extracellular space	IEA	--

FCN3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FCN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FCN3 for domains About GeneDecksing

5 InterPro domains/families:

IPR014715 Fibrinogen_a/b/g_C_2

IPR014716 Fibrinogen_a/b/g_C_1

IPR020837 Fibrinogen_CS

IPR002181 Fibrinogen_a/b/g_C_dom

IPR008160 Collagen

Graphical View of Domain Structure for InterPro Entry O75636

ProtoNet protein and cluster: O75636

2 Blocks protein families:

IPB002181 Fibrinogen

IPB008160 Collagen triple helix repeat

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636

Similarity: Belongs to the ficolin lectin family

Similarity: Contains 1 collagen-like domain

Similarity: Contains 1 fibrinogen C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FCN3_HUMAN, O75636

Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and

GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides

from S.typhimurium and S.minnesota

Genatlas biochemistry entry for FCN3:

ficolin 3 (collagen/fibrinogen domain-containing),TGF1 binding protein,Hakata antigen,present in the serum as

homopolymers,reactin with the serum from patients with systemic lupus erythromatous,expressed in the lung,produced by

both ciliated bronchial epithelial cells and Type II alveolar epithelial cells and was secreted into the bronchus and

alveolus,also expressed in liver,Hakata antigen is produced by bile duct epithelial cells and hepatocytes and secreted

into the bile duct

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005515	protein binding	IPI	11907111
GO:0030246	carbohydrate binding	TAS	9694814

FCN3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for FCN3:

Synthetic lethal with imatinib

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FCN3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_Alternative complement pathway

Immune response_Lectin induced complement pathway

0.56

Immune response Lectin Induced complement pathway

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FCN3

Immune response Lectin Induced complement pathway

1 GeneGo (Thomson Reuters) Pathway for FCN3

Immune response Lectin induced complement pathway

FCN3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FCN3

1 Interacting protein for FCN3 (O75636³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTX3	P26022³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001867	complement activation, lectin pathway	IDA	11907111
GO:0007165	signal transduction	IEA	--

FCN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FCN3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FCN3
3 Novoseek chemical compound relationships for FCN3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	64.8	8	19699205 (1), 16305643 (1), 16644773 (1), 15950722 (1) (see all 8)
mannan	64	3	17303612 (1), 19234189 (1)
polysaccharide	24.9	1	11907111 (1)

Search CenterWatch for drugs/clinical trials and news about FCN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FCN3 gene (2 alternative transcripts):

NM_003665.2 NM_173452.1

Unigene Cluster for FCN3:

Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

Hs.333383 [show with all ESTs]

Unigene Representative Sequence: AL557853

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000270879(uc001boa.3) ENST00000354982(uc001bob.3) ENST00000498393

ENST00000481748

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FCN3 Browse OriGene MicroRNA Expression Plasmids
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCN3

Additional cDNA sequence:

AK075140.1 AK309540.1 AK309576.1 AY358081.1 AY358283.1 BC020731.1 CR456808.1

4 DOTS entries:

DT.95113865 DT.441573 DT.91869506 DT.121386911

24/81 AceView cDNA sequences (see all 81):

CR604997 AI589209 BM313732 AA298470 BM971320 AA345852 AL557854 NM_003665

AK075140 AV653375 NM_173452 BM725707 BM985127 AL557853 AA666363 BU689396

T92148 AI364974 BG548010 BI824643 BQ186384 AY358283 AY358081 BU678151

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FCN3 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8
SP1:							-				-
SP2:							-				-		-
SP3:
SP4:

ECgene alternative splicing isoforms for FCN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FCN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACACCGAGG

About this image

FCN3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FCN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCN3

SOURCE GeneReport for Unigene cluster: Hs.333383

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636

Tissue specificity: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it

is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FCN3 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
fruit fly (Drosophila melanogaster)	Insecta	CG30280³	--	44(a) (best of 4)		--

ENSEMBL Gene Tree for FCN3 (if available)
TreeFam Gene Tree for FCN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FCN3 gene

TNR² FIBCD1² FCN1² FCN2² TNXB² TNN² MFAP4² FN1²

TNC² ANGPTL5²

18/27 SIMAP similar genes for FCN3 using alignment to 3 protein entries: FCN3_HUMAN (see all proteins) (see all similar genes):

ANGPTL2 TNR ANGPT4 TNC ANGPTL3 TNC variant protein

FCN1 ANGPT2 ANGPTL7 FCN2 TNXB ANGPT1

TNN FIBCD1 FGL1 MFAP4 ANGPTL1 FGL2

FCN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28385728^1,2	C,F	--	25951404(-)	`GGCTGG/AAGTGC`	2	--	ds500¹		3		NS CSA	96
rs112502361^1,2	F	--	25951636(+)	`AGGCTC/GTCCTT`	2	--	ds500¹		1		CSA	5
rs34295487^1,2	C	--	25951917(+)	`ACGGCC/TTGAGG`	4	S G	mis¹		1		NA	2
rs28385651^1,2	C,F	--	25952470(-)	`GCCTCA/GGGGAA`	2	--	int¹		3		NS NA	214
rs28385650^1,2	C,F	--	25952691(-)	`TCACTG/ACACTC`	2	--	int¹		2		NS	92
rs113797761^1,2	C	--	25953470(+)	`GAACTC/G/TACCCT`	2	--	int¹		1		CSA	1
rs41291100^1,2		--	25953683(+)	`TGGGTA/GGATAC`	2	--	int¹		0	--	--	--	--
rs12405299^1,2	C,H	--	25953879(+)	`CGCTGC/TTGGGT`	2	--	int¹		0	--	--	--	--
rs28362807^1,2	C,F	--	25953927(-)	`AGCGT-/GGC CAAATATCTTG`	2	--	int¹		3		NS CSA	96
rs29001532^1,2	C,F	--	25953972(-)	`CGCCTC/TGGCCT`	2	--	int¹		2		NS	94

HapMap Linkage Disequilibrium report for FCN3 (27695601 - 27701315 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FCN3
1 CNV: 48306
Human Gene Mutation Database (HGMD): FCN3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCN3

DNA2.0 Custom Variant and Variant Library Synthesis for FCN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FCN3 for disorders About GeneDecksing

OMIM gene information: 604973 OMIM disorders: --

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636

Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:613860]. FCN3D is a disorder characterized

by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals

have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody

response to pneumococcal polysaccharide vaccine

17 diseases for FCN3: About MalaCards

systemic lupus erythematosus lupus erythematosus proliferative diabetic retinopathy diabetic retinopathy

rheumatic fever rheumatoid arthritis neutropenia crohn's disease

hepatitis b hepatoblastoma gout sarcoidosis

hepatocellular carcinoma arthritis hepatitis immunodeficiency

carcinoma

1 disease from the University of Copenhagen DISEASES database for FCN3:

Autistic disorder

Human Genome Epidemiology (HuGE) Navigator: FCN3 (4 documents)

Export disorders for FCN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FCN3 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with FCN3)

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Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. (PubMed id 10330454)^{1, 2, 3} Akaiwa M....Hamasaki N. (1999)
Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. (PubMed id 9694814)^{1, 2, 3} Sugimoto R.... Hamasaki N. (1998)
Activation of the lectin complement pathway by H-ficolin (Hakata antigen). (PubMed id 11907111)^{1, 2, 9} Matsushita M....Fujita T. (2002)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state. (PubMed id 18261799)^{1, 9} Munthe-Fog L....Garred P. (2008)
Immunodeficiency associated with FCN3 mutation and fi colin-3 deficiency. (PubMed id 19535802)^{2, 9} Munthe-Fog L....Garred P. (2009)
Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen). (PubMed id 18006063)^{1, 9} Hummelshoej T.... Garred P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8547	HGNC: 3625	AceView: FCN3	Ensembl:ENSG00000142748	euGenes: HUgn8547
ECgene: FCN3	H-InvDB: FCN3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FCN3	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/fcn3/

Intellectual Property for FCN3 gene
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Patent Information for FCN3 gene:
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