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Aliases for FCN3 Gene

Aliases for FCN3 Gene

  • Ficolin 3 2 3 5
  • Collagen/Fibrinogen Domain-Containing Lectin 3 P35 3 4
  • Collagen/Fibrinogen Domain-Containing Protein 3 3 4
  • Hakata Antigen 2 4
  • HAKA1 3 4
  • FCNH 3 4
  • Ficolin (Collagen/Fibrinogen Domain-Containing) 3 (Hakata Antigen) 2
  • Ficolin (Collagen/Fibrinogen Domain Containing) 3 (Hakata Antigen) 3
  • Ficolin (Collagen/Fibrinogen Domain Containing) 3 2
  • H-Ficolin 3

External Ids for FCN3 Gene

Previous GeneCards Identifiers for FCN3 Gene

  • GC01P027890
  • GC01M026727
  • GC01M026928
  • GC01M027300
  • GC01M027568
  • GC01M027695
  • GC01M025951

Summaries for FCN3 Gene

Entrez Gene Summary for FCN3 Gene

  • Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCN3 Gene

FCN3 (Ficolin 3) is a Protein Coding gene. Diseases associated with FCN3 include immunodeficiency due to ficolin 3 deficiency and rheumatic fever. Among its related pathways are Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include carbohydrate binding and antigen binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for FCN3 Gene

  • May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.

Gene Wiki entry for FCN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCN3 Gene

Genomics for FCN3 Gene

Regulatory Elements for FCN3 Gene

Genomic Location for FCN3 Gene

Chromosome:
1
Start:
27,369,110 bp from pter
End:
27,374,825 bp from pter
Size:
5,716 bases
Orientation:
Minus strand

Genomic View for FCN3 Gene

Genes around FCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCN3 Gene

Proteins for FCN3 Gene

  • Protein details for FCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75636-FCN3_HUMAN
    Recommended name:
    Ficolin-3
    Protein Accession:
    O75636
    Secondary Accessions:
    • Q6IBJ5
    • Q8WW86

    Protein attributes for FCN3 Gene

    Size:
    299 amino acids
    Molecular mass:
    32903 Da
    Quaternary structure:
    • Homotrimer (PubMed:17215869). May form an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.

    Three dimensional structures from OCA and Proteopedia for FCN3 Gene

    Alternative splice isoforms for FCN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCN3 Gene

Proteomics data for FCN3 Gene at MOPED

Post-translational modifications for FCN3 Gene

Other Protein References for FCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FCN3 Gene

Domains & Families for FCN3 Gene

Gene Families for FCN3 Gene

Suggested Antigen Peptide Sequences for FCN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75636

UniProtKB/Swiss-Prot:

FCN3_HUMAN :
  • Contains 1 collagen-like domain.
  • Belongs to the ficolin lectin family.
Domain:
  • Contains 1 collagen-like domain.
  • Contains 1 fibrinogen C-terminal domain.
Family:
  • Belongs to the ficolin lectin family.
genes like me logo Genes that share domains with FCN3: view

Function for FCN3 Gene

Molecular function for FCN3 Gene

GENATLAS Biochemistry:
ficolin 3 (collagen/fibrinogen domain-containing),TGF1 binding protein,Hakata antigen,present in the serum as homopolymers,reactin with the serum from patients with systemic lupus erythromatous,expressed in the lung,produced by both ciliated bronchial epithelial cells and Type II alveolar epithelial cells and was secreted into the bronchus and alveolus,also expressed in liver,Hakata antigen is produced by bile duct epithelial cells and hepatocytes and secreted into the bile duct
UniProtKB/Swiss-Prot Function:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.

Gene Ontology (GO) - Molecular Function for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with FCN3: view
genes like me logo Genes that share phenotypes with FCN3: view

Human Phenotype Ontology for FCN3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for FCN3

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCN3 Gene

Localization for FCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCN3 Gene

Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCN3 Gene COMPARTMENTS Subcellular localization image for FCN3 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with FCN3: view

Pathways & Interactions for FCN3 Gene

genes like me logo Genes that share pathways with FCN3: view

Pathways by source for FCN3 Gene

Interacting Proteins for FCN3 Gene

Gene Ontology (GO) - Biological Process for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0006508 proteolysis TAS --
GO:0006956 complement activation TAS --
GO:0045087 innate immune response TAS --
GO:0051607 defense response to virus IDA 22851708
genes like me logo Genes that share ontologies with FCN3: view

No data available for SIGNOR curated interactions for FCN3 Gene

Drugs & Compounds for FCN3 Gene

(1) Drugs for FCN3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FCN3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCN3: view

Transcripts for FCN3 Gene

Unigene Clusters for FCN3 Gene

Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for FCN3 Gene

GeneLoc Exon Structure for
FCN3
ECgene alternative splicing isoforms for
FCN3

Expression for FCN3 Gene

mRNA expression in normal human tissues for FCN3 Gene

mRNA differential expression in normal tissues according to GTEx for FCN3 Gene

This gene is overexpressed in Lung (x26.4) and Liver (x6.5).

Protein differential expression in normal tissues from HIPED for FCN3 Gene

This gene is overexpressed in Serum (35.7), Plasma (20.6), and Synovial fluid (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCN3 Gene



SOURCE GeneReport for Unigene cluster for FCN3 Gene Hs.333383

mRNA Expression by UniProt/SwissProt for FCN3 Gene

O75636-FCN3_HUMAN
Tissue specificity: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.
genes like me logo Genes that share expression patterns with FCN3: view

Protein tissue co-expression partners for FCN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FCN3 Gene

Orthologs for FCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCN3 35
  • 96.65 (n)
  • 94.42 (a)
FCN3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCN3 35
  • 77.45 (n)
  • 66.79 (a)
mouse
(Mus musculus)
Mammalia Fcna 36
  • 44 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG41520 36
  • 13 (a)
OneToMany
CG30280 37
  • 44 (a)
CG30281 37
  • 44 (a)
CG5550 37
  • 41 (a)
sca 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea T15B7.1 35
  • 44.91 (n)
  • 38.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
Species with no ortholog for FCN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FCN3 Gene

ENSEMBL:
Gene Tree for FCN3 (if available)
TreeFam:
Gene Tree for FCN3 (if available)

Paralogs for FCN3 Gene

Paralogs for FCN3 Gene

genes like me logo Genes that share paralogs with FCN3: view

Variants for FCN3 Gene

Sequence variations from dbSNP and Humsavar for FCN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4134410 -- 27,376,554(-) TTCCA(C/T)ACTGA upstream-variant-2KB
rs4582825 -- 27,375,918(-) GAGAC(A/G)GGGTT upstream-variant-2KB
rs6699625 -- 27,374,293(+) GACAA(A/G)AATTG intron-variant
rs10794501 -- 27,372,958(+) TCAAA(A/T)GGCAC intron-variant
rs11247642 -- 27,372,521(+) GGGAT(C/T)ATAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCN3 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680
dgv204n71 CNV Loss 21882294
nsv870665 CNV Loss 21882294
esv1006916 CNV Deletion 20482838

Variation tolerance for FCN3 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCN3 Gene

HapMap Linkage Disequilibrium report
FCN3
Human Gene Mutation Database (HGMD)
FCN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCN3 Gene

Disorders for FCN3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FCN3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency due to ficolin 3 deficiency
  • ficolin 3 deficiency
rheumatic fever
  • acute rheumatic fever
hereditary angioedema
  • c1 inhibitor deficiency
rheumatic heart disease
  • rhd
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards
Search FCN3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FCN3_HUMAN
  • Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. {ECO:0000269 PubMed:19535802}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FCN3

Genetic Association Database (GAD)
FCN3
Human Genome Epidemiology (HuGE) Navigator
FCN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCN3
genes like me logo Genes that share disorders with FCN3: view

No data available for Genatlas for FCN3 Gene

Publications for FCN3 Gene

  1. Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. (PMID: 10330454) Akaiwa M. … Hamasaki N. (J. Histochem. Cytochem. 1999) 2 3 4 67
  2. Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin. (PMID: 19109177) Lacroix M. … Thielens N.M. (J. Immunol. 2009) 3 23
  3. Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus. (PMID: 19208603) Andersen T. … Jacobsen S. (J. Rheumatol. 2009) 3 23
  4. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PMID: 19220833) Ruskamp J.M. … Sanders E.A. (Clin. Exp. Immunol. 2009) 3 23
  5. Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen). (PMID: 18006063) Hummelshoej T. … Garred P. (Mol. Immunol. 2008) 3 23

Products for FCN3 Gene

Sources for FCN3 Gene

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