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Aliases for FCN3 Gene

Aliases for FCN3 Gene

  • Ficolin (Collagen/Fibrinogen Domain Containing) 3 2 3
  • HAKA1 3 4 6
  • Collagen/Fibrinogen Domain-Containing Lectin 3 P35 3 4
  • Collagen/Fibrinogen Domain-Containing Protein 3 3 4
  • Hakata Antigen 2 4
  • FCNH 3 4
  • Ficolin (Collagen/Fibrinogen Domain-Containing) 3 (Hakata Antigen) 2
  • Ficolin (Collagen/Fibrinogen Domain Containing) 3 (Hakata Antigen) 3
  • Ficolin 3 3
  • H-Ficolin 3
  • Ficolin-3 3

External Ids for FCN3 Gene

Summaries for FCN3 Gene

Entrez Gene Summary for FCN3 Gene

  • Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCN3 Gene

FCN3 (Ficolin (Collagen/Fibrinogen Domain Containing) 3) is a Protein Coding gene. Diseases associated with FCN3 include immunodeficiency due to ficolin 3 deficiency and rheumatic fever. Among its related pathways are Complement Pathway and Creation of C4 and C2 activators. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for FCN3 Gene

  • May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.

Gene Wiki entry for FCN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCN3 Gene

Genomics for FCN3 Gene

Genomic Location for FCN3 Gene

Start:
27,369,110 bp from pter
End:
27,374,824 bp from pter
Size:
5,715 bases
Orientation:
Minus strand

Genomic View for FCN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCN3 Gene

Regulatory Elements for FCN3 Gene

Proteins for FCN3 Gene

  • Protein details for FCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75636-FCN3_HUMAN
    Recommended name:
    Ficolin-3
    Protein Accession:
    O75636
    Secondary Accessions:
    • Q6IBJ5
    • Q8WW86

    Protein attributes for FCN3 Gene

    Size:
    299 amino acids
    Molecular mass:
    32903 Da
    Quaternary structure:
    • Homopolymer; disulfide-linked. May be an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.

    Three dimensional structures from OCA and Proteopedia for FCN3 Gene

    Alternative splice isoforms for FCN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCN3 Gene

Proteomics data for FCN3 Gene at MOPED

Post-translational modifications for FCN3 Gene

Other Protein References for FCN3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FCN3 Gene

Domains for FCN3 Gene

Gene Families for FCN3 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for FCN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75636

UniProtKB/Swiss-Prot:

FCN3_HUMAN
Domain:
  • Contains 1 collagen-like domain.:
    • O75636
  • Contains 1 fibrinogen C-terminal domain.:
    • O75636
Family:
  • Belongs to the ficolin lectin family.:
    • O75636
genes like me logo Genes that share domains with FCN3: view

Function for FCN3 Gene

Molecular function for FCN3 Gene

GENATLAS Biochemistry: ficolin 3 (collagen/fibrinogen domain-containing),TGF1 binding protein,Hakata antigen,present in the serum as homopolymers,reactin with the serum from patients with systemic lupus erythromatous,expressed in the lung,produced by both ciliated bronchial epithelial cells and Type II alveolar epithelial cells and was secreted into the bronchus and alveolus,also expressed in liver,Hakata antigen is produced by bile duct epithelial cells and hepatocytes and secreted into the bile duct
UniProtKB/Swiss-Prot Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.

Gene Ontology (GO) - Molecular Function for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IDA 22851708
GO:0005515 protein binding IPI 11907111
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with FCN3: view

Phenotypes for FCN3 Gene

GenomeRNAi human phenotypes for FCN3:
genes like me logo Genes that share phenotypes with FCN3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FCN3 Gene

Localization for FCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCN3 Gene

Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCN3 Gene COMPARTMENTS Subcellular localization image for FCN3 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with FCN3: view

Pathways for FCN3 Gene

genes like me logo Genes that share pathways with FCN3: view

Interacting Proteins for FCN3 Gene

Gene Ontology (GO) - Biological Process for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0006956 complement activation TAS --
GO:0043654 recognition of apoptotic cell IDA 15804047
GO:0045087 innate immune response TAS --
GO:0046597 negative regulation of viral entry into host cell IMP 22851708
genes like me logo Genes that share ontologies with FCN3: view

Compounds for FCN3 Gene

(3) Novoseek inferred chemical compound relationships for FCN3 Gene

Compound -log(P) Hits PubMed IDs
serine 64.8 8
mannan 64 2
polysaccharide 24.9 1
genes like me logo Genes that share compounds with FCN3: view

Transcripts for FCN3 Gene

Unigene Clusters for FCN3 Gene

Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for FCN3 Gene

GeneLoc Exon Structure for
FCN3
ECgene alternative splicing isoforms for
FCN3

Expression for FCN3 Gene

mRNA expression in normal human tissues for FCN3 Gene

mRNA differential expression in normal tissues according to GTEx for FCN3 Gene

This gene is overexpressed in Lung (26.4) and Liver (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCN3 Gene

SOURCE GeneReport for Unigene cluster for FCN3 Gene Hs.333383

mRNA Expression by UniProt/SwissProt for FCN3 Gene

O75636-FCN3_HUMAN
Tissue specificity: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.
genes like me logo Genes that share expressions with FCN3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FCN3 Gene

Orthologs for FCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCN3 35
  • 96.65 (n)
  • 94.42 (a)
FCN3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCN3 35
  • 77.45 (n)
  • 66.79 (a)
mouse
(Mus musculus)
Mammalia Fcna 36
  • 44 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG41520 36
  • 13 (a)
OneToMany
CG30281 37
  • 44 (a)
sca 37
  • 38 (a)
CG30280 37
  • 44 (a)
CG5550 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea T15B7.1 35
  • 44.91 (n)
  • 38.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
Species with no ortholog for FCN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FCN3 Gene

ENSEMBL:
Gene Tree for FCN3 (if available)
TreeFam:
Gene Tree for FCN3 (if available)

Paralogs for FCN3 Gene

genes like me logo Genes that share paralogs with FCN3: view

Variants for FCN3 Gene

Sequence variations from dbSNP and Humsavar for FCN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15544 -- 27,374,380(-) CTGGG(G/T)AGAAG reference, stop-gained
rs1127691 -- 27,373,164(-) TTGTG(A/T)CATGG reference, missense
rs3813800 -- 27,370,983(+) GGAGG(C/G/T)GGGGC intron-variant
rs4134410 -- 27,376,554(-) TTCCA(C/T)ACTGA upstream-variant-2KB
rs4494157 -- 27,370,346(-) CTCCA(A/C)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCN3 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680
dgv204n71 CNV Loss 21882294
nsv870665 CNV Loss 21882294
esv1006916 CNV Deletion 20482838

Relevant External Links for FCN3 Gene

HapMap Linkage Disequilibrium report
FCN3
Human Gene Mutation Database (HGMD)
FCN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCN3 Gene

Disorders for FCN3 Gene

(1) OMIM Diseases for FCN3 Gene (604973)

UniProtKB/Swiss-Prot

FCN3_HUMAN
  • Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. {ECO:0000269 PubMed:19535802}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FCN3 Gene

Relevant External Links for FCN3

Genetic Association Database (GAD)
FCN3
Human Genome Epidemiology (HuGE) Navigator
FCN3
genes like me logo Genes that share disorders with FCN3: view

Publications for FCN3 Gene

  1. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). (PMID: 11907111) Matsushita M. … Fujita T. (J. Immunol. 2002) 3 4 23
  2. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PMID: 18032536) Vander Cruyssen B. … De Keyser F. (Rheumatology (Oxford) 2007) 3 23 48
  3. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PMID: 19220833) Ruskamp J.M. … Sanders E.A. (Clin. Exp. Immunol. 2009) 3 23 48
  4. Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. (PMID: 9694814) Sugimoto R. … Hamasaki N. (J. Biol. Chem. 1998) 2 3 4
  5. Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. (PMID: 10330454) Akaiwa M. … Hamasaki N. (J. Histochem. Cytochem. 1999) 2 3 4

Products for FCN3 Gene

Sources for FCN3 Gene

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