Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FCN3 Gene

protein-coding   GIFtS: 62
GCID: GC01M027695

Ficolin (Collagen/Fibrinogen Domain Containing) 3

(Previous name: ficolin (collagen/fibrinogen domain-containing) 3 (Hakata...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ficolin (Collagen/Fibrinogen Domain Containing) 31 2     Ficolin (Collagen/Fibrinogen Domain-Containing) 3 (Hakata Antigen)1
HAKA12 3 5     H-ficolin2
Hakata Antigen1 3     Ficolin (Collagen/Fibrinogen Domain Containing) 3 (Hakata Antigen)2
Collagen/Fibrinogen Domain-Containing Lectin 3 P352 3     Ficolin 32
Collagen/Fibrinogen Domain-Containing Protein 32 3     ficolin-32
FCNH2 3     

External Ids:    HGNC: 36251   Entrez Gene: 85472   Ensembl: ENSG000001427487   OMIM: 6049735   UniProtKB: O756363   

Export aliases for FCN3 gene to outside databases

Previous GC identifers: GC01P027890 GC01M026727 GC01M026928 GC01M027300 GC01M027379 GC01M027568 GC01M025951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FCN3 Gene:
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human
serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a
thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin
family. The protein, which was initially identified based on its reactivity with sera from patients with systemic
lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the
complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of
the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform,
have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FCN3 Gene:
FCN3 (ficolin (collagen/fibrinogen domain containing) 3) is a protein-coding gene. Diseases associated with FCN3 include immunodeficiency due to ficolin 3 deficiency, and mannose-binding lectin deficiency. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and
lipopolysaccharides from S.typhimurium and S.minnesota

Gene Wiki entry for FCN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCN3 gene promoter:
         Elk-1   NRSF form 1   STAT5A   NRSF form 2   Ik-3   E2F   E2F-1   HOXA5   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCN3 promoter sequence
   Search Chromatin IP Primers for FCN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

FCN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCN3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027695:  view genomic region     (about GC identifiers)

Start:
27,695,601 bp from pter      End:
27,701,315 bp from pter
Size:
5,715 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636 (See protein sequence)
Recommended Name: Ficolin-3 precursor  
Size: 299 amino acids; 32903 Da
Subunit: Homopolymer; disulfide-linked. May be an octadecamer consisting of an elementary trimer unit. Does not
interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2
4 PDB 3D structures from and Proteopedia for FCN3:
1LA5 (3D)        2J5Z (3D)        2J60 (3D)        2J64 (3D)    
Secondary accessions: Q6IBJ5 Q8WW86
Alternative splicing: 2 isoforms:  O75636-1   O75636-2   

Explore the universe of human proteins at neXtProt for FCN3: NX_O75636

Explore proteomics data for FCN3 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Glycosylation2 at Asn189

  • See FCN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003656.2  NP_775628.1  

    ENSEMBL proteins: 
     ENSP00000270879   ENSP00000347077  
    Reactome Protein details: O75636

    FCN3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCN3 (Ficolin-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FCN3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FCN3
    GenScript Custom Purified and Recombinant Proteins Services for FCN3
    Novus Biologicals FCN3 Protein
    Novus Biologicals FCN3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FCN3

    FCN3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FCN3 (Ficolin-3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FCN3
    Novus Biologicals FCN3 Antibodies
    Abcam antibodies for FCN3
    Cloud-Clone Corp. Antibodies for FCN3
    Search ThermoFisher Antibodies for FCN3
    LSBio Antibodies in human, mouse, rat for FCN3

    FCN3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FCN3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FCN3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FCN3
    Cloud-Clone Corp. CLIAs for FCN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry O75636

    ProtoNet protein and cluster: O75636

    2 Blocks protein domains:
    IPB002181 Fibrinogen
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
    Similarity: Belongs to the ficolin lectin family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 fibrinogen C-terminal domain


    FCN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCN3_HUMAN, O75636
    Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
    and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and
    lipopolysaccharides from S.typhimurium and S.minnesota

         Genatlas biochemistry entry for FCN3:
    ficolin 3 (collagen/fibrinogen domain-containing),TGF1 binding protein,Hakata antigen,present in the serum as
    homopolymers,reactin with the serum from patients with systemic lupus erythromatous,expressed in the
    lung,produced by both ciliated bronchial epithelial cells and Type II alveolar epithelial cells and was secreted
    into the bronchus and alveolus,also expressed in liver,Hakata antigen is produced by bile duct epithelial cells
    and hepatocytes and secreted into the bile duct

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11907111
    GO:0030246carbohydrate binding TAS9694814
         
    FCN3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FCN3:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCN3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FCN3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FCN3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FCN3
    Predesigned siRNA for gene silencing in human, mouse, rat FCN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCN3

    Clone
    Products:
         
    OriGene clones in human, mouse for FCN3 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FCN3 (NM_003665)
    Sino Biological Human cDNA Clone for FCN3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCN3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCN3
    Browse ESI BIO Cell Lines and PureStem Progenitors for FCN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FCN3_HUMAN, O75636: Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0072562blood microparticle IDA--

    FCN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FCN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Ficolins bind to repetitive carbohydrate structures on the target cell surface0.00
    Initial triggering of complement0.85
    Lectin pathway of complement activation0.00
    Complement cascade0.68
    2Complement Pathway
    Immune response Lectin Induced complement pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FCN3
        Immune response Lectin induced complement pathway


    3 Reactome Pathways for FCN3
        Ficolins bind to repetitive carbohydrate structures on the target cell surface
    Lectin pathway of complement activation
    Initial triggering of complement



    FCN3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCN3
    Interactions:

        GeneGlobe Interaction Network for FCN3

    1 Interacting protein for FCN3 (O756363) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTX3P260223I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001867complement activation, lectin pathway TAS--
    GO:0006956complement activation TAS--
    GO:0045087innate immune response TAS--

    FCN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCN3

    3 Novoseek inferred chemical compound relationships for FCN3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 64.8 8 19699205 (1), 16305643 (1), 16644773 (1), 15950722 (1) (see all 8)
    mannan 64 3 17303612 (1), 19234189 (1)
    polysaccharide 24.9 1 11907111 (1)



    FCN3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FCN3 gene (2 alternative transcripts): 
    NM_003665.2  NM_173452.1  

    Unigene Cluster for FCN3:

    Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
    Hs.333383  [show with all ESTs]
    Unigene Representative Sequence: AL557853
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270879(uc001boa.3) ENST00000354982(uc001bob.3) ENST00000498393
    ENST00000481748
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FCN3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FCN3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FCN3
    Predesigned siRNA for gene silencing in human, mouse, rat FCN3
    Clone
    Products:
         
    OriGene clones in human, mouse for FCN3 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FCN3 (NM_003665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCN3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FCN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FCN3
      QuantiTect SYBR Green Assays in human, mouse, rat FCN3
      QuantiFast Probe-based Assays in human, mouse, rat FCN3

    Additional mRNA sequence: 

    AK075140.1 AK309540.1 AK309576.1 AY358081.1 AY358283.1 BC020731.1 CR456808.1 

    4 DOTS entries:

    DT.95113865  DT.441573  DT.91869506  DT.121386911 

    Selected AceView cDNA sequences (see all 81):

    BM971320 BM725707 CR604997 AI589209 AA345852 AV653375 AA298470 BM985127 
    BM313732 AK075140 NM_173452 AL557854 NM_003665 AL557853 BU680746 BI824643 
    BX110478 AI765545 BC020731 AV656789 T64253 BM924811 BI819603 AI346745 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FCN3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                    -           -                                 
    SP2:                    -           -     -                           
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for FCN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FCN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACCGAGG
    FCN3 Expression
    About this image

    FCN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333383

    UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
    Tissue specificity: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung
    it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells

        Custom PCR Arrays for FCN3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FCN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FCN3
    QuantiTect SYBR Green Assays in human, mouse, rat FCN3
    QuantiFast Probe-based Assays in human, mouse, rat FCN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FCN3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    42(a)
    many ↔ many
    1(77130430-77139418)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG302803   -- 44(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea T15B7.11 T15B7.1 44.91(n)
    38.43(a)
      188512  NM_072342.5  NP_504743.3 
            Species with no ortholog for FCN3

    ENSEMBL Gene Tree for FCN3 (if available)
    TreeFam Gene Tree for FCN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FCN3 gene
    FGL22  ANGPT42  FGG2  FIBCD12  ANGPTL62  ANGPTL22  FCN22  FCN12  
    ANGPT12  ANGPTL12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    Selected SIMAP similar genes for FCN3 using alignment to 3 protein entries:     FCN3_HUMAN (see all proteins) (see all similar genes):
    ANGPTL2    TNR    ANGPT4    TNC    ANGPTL3    TNC variant protein
    FCN1    ANGPT2    ANGPTL7    FCN2    ANGPT1    TNN
    TNXB    FIBCD1    MFAP4    FGL1    ANGPTL1    FGL2

    FCN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FCN3 (see all 232)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283628071,2
    C,F--25953927(-) AGCGT-/GGC   
      CAAATA
    TCTTG
    2 -- cds13Minor allele frequency- GGCCAAATA:0.37NS CSA 96
    rs675080141,2
    C--25953928(+) AAGAA-/T/TATC/
    TATTTGGCC
    CGCTT
    4 -- int1 cds10--------
    rs345600381,2
    C,F--27696501(+) TTTTT-/TCTGAG 2 -- int13Minor allele frequency- T:0.33NA CSA 6
    rs283856491,2
    C,F--27699266(-) AAAAAA/TATAGG 2 -- int1 trp33Minor allele frequency- T:0.02NS NA 96
    rs283570921,2
    C,F--27699671(-) CAGGGC/-CCTCC 4 /S /L fra12Minor allele frequency- -:0.02NS 94
    rs283857281,2
    C,F--27914546(-) GGCTGG/AAGTGC 2 -- ds50013Minor allele frequency- A:0.07NS CSA 96
    rs1125023611,2
    F--27914778(+) AGGCTC/GTCCTT 2 -- ds50011Minor allele frequency- G:0.40CSA 5
    rs2022306641,2
    C--27915026(+) CATCCA/GAACCC 4 R W mis10--------
    rs558631541,2
    C,F--27915049(-) TGGTGT/CGGGCC 4 /A /V mis11Minor allele frequency- C:0.00NA 4550
    rs342954871,2
    C--27915059(+) ACGGCC/TTGAGG 4 S G mis11Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for FCN3 (27695601 - 27701315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FCN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1006916CNV Deletion20482838
    nsv516766CNV Loss19592680
    nsv870665CNV Loss21882294
    dgv204n71CNV Loss21882294
    dgv203n71CNV Loss21882294
    nsv526051CNV Gain19592680

    Human Gene Mutation Database (HGMD): FCN3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCN3
    DNA2.0 Custom Variant and Variant Library Synthesis for FCN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604973   
    OMIM disorders: 613860  
    UniProtKB/Swiss-Prot: FCN3_HUMAN, O75636
  • Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent
    infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of
    lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to
    pneumococcal polysaccharide vaccine. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for FCN3 (see all 27):    About MalaCards
    immunodeficiency due to ficolin 3 deficiency    mannose-binding lectin deficiency    rheumatic fever    autistic disorder
    systemic lupus erythematosus    lupus erythematosus    proliferative diabetic retinopathy    gout
    diabetic retinopathy    eclampsia    hepatoblastoma    pre-eclampsia
    neutropenia    sarcoidosis    essential hypertension    crohn's disease
    influenza    hypertension    hepatitis b    rheumatoid arthritis

    1 disease from the University of Copenhagen DISEASES database for FCN3:
    Autistic disorder

    FCN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FCN3
    Human Genome Epidemiology (HuGE) Navigator: FCN3 (4 documents)

    Export disorders for FCN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FCN3 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with FCN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. (PubMed id 10330454)1, 2, 3 Akaiwa M....Hamasaki N. (J. Histochem. Cytochem. 1999)
    2. Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. (PubMed id 9694814)1, 2, 3 Sugimoto R.... Hamasaki N. (J. Biol. Chem. 1998)
    3. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). (PubMed id 11907111)1, 2, 9 Matsushita M....Fujita T. (J. Immunol. 2002)
    4. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PubMed id 19220833)1, 4, 9 Ruskamp J.M....Sanders E.A. (Clin. Exp. Immunol. 2009)
    5. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PubMed id 18032536)1, 4, 9 Vander Cruyssen B....De Keyser F. (Rheumatology (Oxford) 2007)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state. (PubMed id 18261799)1, 9 Munthe-Fog L....Garred P. (Mol. Immunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8547 HGNC: 3625 AceView: FCN3 Ensembl:ENSG00000142748 euGenes: HUgn8547
    ECgene: FCN3 H-InvDB: FCN3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FCN3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/fcn3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCN3 gene:
    Search GeneIP for patents involving FCN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for FCN3 (Ficolin-3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FCN3 (Ficolin-3)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FCN3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FCN3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FCN3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FCN3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCN3   OriGene Custom Protein Services for FCN3  

     
     
     Block miRNA regulation of human, mouse, rat FCN3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FCN3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCN3 Predesigned siRNA for gene silencing in human, mouse, rat FCN3
     QuantiFast Probe-based Assays in human, mouse, rat FCN3 QuantiTect SYBR Green Assays in human, mouse, rat FCN3
     Custom PCR Arrays for FCN3 Search Chromatin IP Primers for FCN3
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FCN3  GeneGlobe Interaction Network for FCN3
     Regulatory tfbs in FCN3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FCN3 GenScript cDNA clones with any tag delivered in your preferred vector for FCN3
     GenScript Custom Assay Services for FCN3 GenScript Custom overexpressing Cell Line Services for FCN3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FCN3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FCN3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FCN3 antibodies
     FCN3 proteins
     FCN3 lysates
     Antibodies for FCN3
     See all of Abcam's Antibodies, Kits and Proteins for FCN3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FCN3
     Antibodies for FCN3
     ELISAs for FCN3
     CLIAs for FCN3



     Browse ESI BIO Cell Lines and PureStem Progenitors for FCN3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FCN3
     SwitchGear Promoter luciferase reporter plasmids for FCN3
     Search ThermoFisher Antibodies for FCN3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCN3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCN3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCN3
     LSBio Antibodies in human, mouse, rat for FCN3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FCN3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4