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Aliases for FCN2 Gene

Aliases for FCN2 Gene

  • Ficolin 2 2 3 5
  • Collagen/Fibrinogen Domain-Containing Protein 2 2 3 4
  • Serum Lectin P35 2 3 4
  • L-Ficolin 2 3 4
  • 37 KDa Elastin-Binding Protein 3 4
  • Ficolin-Beta 3 4
  • Ficolin B 2 3
  • Ficolin-B 3 4
  • Hucolin 2 4
  • EBP-37 3 4
  • FCNL 3 4
  • Ficolin (Collagen/Fibrinogen Domain-Containing Lectin) 2 (Hucolin) 2
  • Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin) 3
  • Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 2
  • Ficolin-2 3
  • P35 3

External Ids for FCN2 Gene

Previous GeneCards Identifiers for FCN2 Gene

  • GC09P128922
  • GC09P129541
  • GC09P131295
  • GC09P133211
  • GC09P134998
  • GC09P136912
  • GC09P137772
  • GC09P107236

Summaries for FCN2 Gene

Entrez Gene Summary for FCN2 Gene

  • The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCN2 Gene

FCN2 (Ficolin 2) is a Protein Coding gene. Diseases associated with FCN2 include progressive relapsing multiple sclerosis and rheumatic fever. Among its related pathways are Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for FCN2 Gene

  • May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.

Gene Wiki entry for FCN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCN2 Gene

Genomics for FCN2 Gene

Regulatory Elements for FCN2 Gene

Genomic Location for FCN2 Gene

Chromosome:
9
Start:
134,864,156 bp from pter
End:
134,889,286 bp from pter
Size:
25,131 bases
Orientation:
Plus strand

Genomic View for FCN2 Gene

Genes around FCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCN2 Gene

Proteins for FCN2 Gene

  • Protein details for FCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15485-FCN2_HUMAN
    Recommended name:
    Ficolin-2
    Protein Accession:
    Q15485
    Secondary Accessions:
    • A6NFG7
    • A8K478
    • Q6IS69
    • Q7M4P4
    • Q9UC57

    Protein attributes for FCN2 Gene

    Size:
    313 amino acids
    Molecular mass:
    34001 Da
    Quaternary structure:
    • Homotrimer (PubMed:17215869). Interacts with elastin. Interacts with MASP1 and MASP2.

    Three dimensional structures from OCA and Proteopedia for FCN2 Gene

    Alternative splice isoforms for FCN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCN2 Gene

Proteomics data for FCN2 Gene at MOPED

Post-translational modifications for FCN2 Gene

  • Glycosylation at Asn 240 and Asn 300

Other Protein References for FCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FCN2 Gene

Domains & Families for FCN2 Gene

Gene Families for FCN2 Gene

Suggested Antigen Peptide Sequences for FCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15485

UniProtKB/Swiss-Prot:

FCN2_HUMAN :
  • The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.
  • Belongs to the ficolin lectin family.
Domain:
  • The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.
  • Contains 1 collagen-like domain.
  • Contains 1 fibrinogen C-terminal domain.
Family:
  • Belongs to the ficolin lectin family.
genes like me logo Genes that share domains with FCN2: view

Function for FCN2 Gene

Molecular function for FCN2 Gene

GENATLAS Biochemistry:
ficolin 2 (ficolin/opronin p35) lectin family,TGFB1 binding protein P35,expressed in liver
UniProtKB/Swiss-Prot Function:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.

Gene Ontology (GO) - Molecular Function for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0043394 proteoglycan binding IDA 8576206
GO:0048306 calcium-dependent protein binding IPI 12421953
genes like me logo Genes that share ontologies with FCN2: view

Phenotypes for FCN2 Gene

GenomeRNAi human phenotypes for FCN2:
genes like me logo Genes that share phenotypes with FCN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FCN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCN2 Gene

Localization for FCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCN2 Gene COMPARTMENTS Subcellular localization image for FCN2 gene
Compartment Confidence
extracellular 5
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for FCN2 Gene

Pathways & Interactions for FCN2 Gene

genes like me logo Genes that share pathways with FCN2: view

Pathways by source for FCN2 Gene

Gene Ontology (GO) - Biological Process for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0006508 proteolysis TAS --
GO:0045087 innate immune response TAS --
GO:0050830 defense response to Gram-positive bacterium IDA 14707097
genes like me logo Genes that share ontologies with FCN2: view

No data available for SIGNOR curated interactions for FCN2 Gene

Drugs & Compounds for FCN2 Gene

(2) Drugs for FCN2 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(6) Additional Compounds for FCN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCN2: view

Transcripts for FCN2 Gene

mRNA/cDNA for FCN2 Gene

Unigene Clusters for FCN2 Gene

Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCN2 Gene

No ASD Table

Relevant External Links for FCN2 Gene

GeneLoc Exon Structure for
FCN2
ECgene alternative splicing isoforms for
FCN2

Expression for FCN2 Gene

mRNA expression in normal human tissues for FCN2 Gene

mRNA differential expression in normal tissues according to GTEx for FCN2 Gene

This gene is overexpressed in Liver (x28.5) and Adrenal Gland (x9.1).

Protein differential expression in normal tissues from HIPED for FCN2 Gene

This gene is overexpressed in Serum (52.3) and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCN2 Gene



SOURCE GeneReport for Unigene cluster for FCN2 Gene Hs.54517

mRNA Expression by UniProt/SwissProt for FCN2 Gene

Q15485-FCN2_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with FCN2: view

Protein tissue co-expression partners for FCN2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FCN2 Gene

Orthologs for FCN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCN2 35
  • 98.4 (n)
  • 97.44 (a)
FCN2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCNB 36
  • 60 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Fcnb 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10359 37
  • 37 (a)
CG1791 37
  • 42 (a)
CG30280 37
  • 44 (a)
CG30281 37
  • 44 (a)
CG5550 37
  • 44 (a)
CG8642 37
  • 42 (a)
CG9500 37
  • 42 (a)
sca 37
  • 42 (a)
CG41520 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for FCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCN2 Gene

ENSEMBL:
Gene Tree for FCN2 (if available)
TreeFam:
Gene Tree for FCN2 (if available)

Paralogs for FCN2 Gene

Paralogs for FCN2 Gene

Pseudogenes.org Pseudogenes for FCN2 Gene

genes like me logo Genes that share paralogs with FCN2: view

Variants for FCN2 Gene

Sequence variations from dbSNP and Humsavar for FCN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036342 A colorectal cancer sample
rs17549179 - 134,885,274(+) GAGGG(C/T)ACTTC reference, missense
rs12684476 - 134,885,286(+) TGAGC(A/C/G)GCTGG reference, missense
rs17549193 - 134,887,180(+) CCTGA(C/T)GTTCC reference, missense
rs7851696 - 134,887,245(+) ATTGT(C/G/T)CTGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FCN2 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894195 CNV Gain 21882294
nsv894199 CNV Loss 21882294
nsv831753 CNV Loss 17160897

Variation tolerance for FCN2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.58; 94.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCN2 Gene

HapMap Linkage Disequilibrium report
FCN2
Human Gene Mutation Database (HGMD)
FCN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCN2 Gene

Disorders for FCN2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FCN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
progressive relapsing multiple sclerosis
  • prms
rheumatic fever
  • acute rheumatic fever
rheumatic heart disease
  • rhd
bronchiectasis
  • kartagener syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FCN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCN2

Genetic Association Database (GAD)
FCN2
Human Genome Epidemiology (HuGE) Navigator
FCN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCN2
genes like me logo Genes that share disorders with FCN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCN2 Gene

Publications for FCN2 Gene

  1. Cloning and characterization of the human lectin P35 gene and its related gene. (PMID: 8884275) Endo Y. … Fujita T. (Genomics 1996) 2 3 4 23 67
  2. Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. (PMID: 18950864) Swierzko A.S. … Kilpatrick D.C. (Mol. Immunol. 2009) 3 23
  3. Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin. (PMID: 19109177) Lacroix M. … Thielens N.M. (J. Immunol. 2009) 3 23
  4. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PMID: 19220833) Ruskamp J.M. … Sanders E.A. (Clin. Exp. Immunol. 2009) 3 23
  5. Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (PMID: 19434912) de Messias-Reason I. … Kun J.F. (J. Infect. Dis. 2009) 3 23

Products for FCN2 Gene

Sources for FCN2 Gene

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