FCN2 Gene
protein-coding GIFtS: 61
GCID: GC09P137772
|
|
ficolin (collagen/fibrinogen domain containing lectin) 2...(Previous name: ficolin (collagen/fibrinogen domain-containing lectin)...)
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Aliases
for FCN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin)1 2 | | L-Ficolin1 | | EBP-371 2 3 | | Ficolin (Collagen/Fibrinogen Domain-Containing Lectin) 2 (Hucolin)1 | | FCNL1 2 3 | | Ficolin B2 | | P351 2 | | Ficolin-B3 | | Ficolin-21 | | Ficolin-Beta1 | | Collagen/Fibrinogen Domain-Containing Protein 22 3 | | Ficolin-B3 | | Serum Lectin P352 3 | | Ficolin-Beta1 | | 37 KDa Elastin-Binding Protein2 3 | | Hucolin3 |
Export aliases for FCN2 gene to outside databasesPrevious GC identifers: GC09P128922 GC09P129541 GC09P131295 GC09P133211 GC09P134998 GC09P136912 GC09P107236 |
Summaries
for FCN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FCN2:
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of aleader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-likedomain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonicactivities. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent andGlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via thecollagen region
Gene Wiki entry for FCN2
|
Genomic Views
for FCN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_019501.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCN2 gene promoter:
AREB6 USF1 p53 USF-1 YY1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34FCN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P137772: view genomic region
(about GC identifiers)
Start:
|
137,772,654 bp from pter |
End:
|
137,779,924 bp from pter |
Size:
|
7,271 bases |
Orientation:
|
plus strand |
|
Proteins
for FCN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485 (See
protein sequence)Recommended Name: Ficolin-2 precursor Size: 313 amino acids; 34001 Da
Subunit: Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2
Subcellular location: Secreted
6/10 PDB 3D structures from  and Proteopedia  for FCN2 (see all 10):2J0G (3D)
2J0H (3D)
2J0Y (3D)
2J1G (3D)
2J2P (3D)
2J3F (3D)
Secondary accessions: A6NFG7 A8K478 Q6IS69 Q7M4P4 Q9UC57Alternative splicing: 2 isoforms: Q15485-1 Q15485-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FCN2: NX_Q15485
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15485
FCN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004099.2 NP_056652.1
ENSEMBL proteins: ENSP00000291744 ENSP00000291741
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FCN2 for ontologies About GeneDecksing
FCN2 Antibody Products:
Assay Products for FCN2: |
Protein
Domains /
Families
for FCN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCN2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15485ProtoNet protein and cluster: Q15485 2 Blocks protein families: IPB002181 Fibrinogen IPB008160 Collagen triple helix repeat
UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485Domain: The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydratebindingSimilarity: Belongs to the ficolin lectin familySimilarity: Contains 1 collagen-like domainSimilarity: Contains 1 fibrinogen C-terminal domain |
Function
for FCN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent andGlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via thecollagen region Genatlas biochemistry entry for FCN2:ficolin 2 (ficolin/opronin p35) lectin family,TGFB1 binding protein P35,expressed in liver
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCN2 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
FCN2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FCN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_Alternative complement pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for FCN2
1  GeneGo (Thomson Reuters) Pathway for FCN2
FCN2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCN2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for FCN2 (Q154852, 3 ENSP000002917444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FCN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FCN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FCN2 for compounds About GeneDecksing
 Browse Tocris compounds for FCN2
1 HMDB Compound for FCN2 About this table
7 Novoseek chemical compound relationships for FCN2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| serine |
62.3 |
10 |
19699205 (1), 16305643 (1), 16644773 (1), 19334557 (1) (see all 9) |
| mannan |
59.7 |
4 |
10232391 (2), 19234189 (1) |
| n-acetylglucosamine |
51.6 |
4 |
15879437 (1), 20032467 (1), 15611266 (1) |
| 1,3-beta-d-glucan |
49.9 |
1 |
15078867 (1) |
| polysaccharide |
39.7 |
6 |
17680820 (1), 20032467 (1), 18486240 (1) |
| sialic acid |
29.5 |
6 |
20032467 (2), 17938215 (2) |
| fibrinogen |
12.4 |
1 |
20032467 (1) |
Search CenterWatch for drugs/clinical trials and news about FCN2
|
Transcripts
for FCN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCN2 gene (4 alternative transcripts): NM_004108.2 NM_015837.2 NM_015838.1 NM_015839.1 Unigene Cluster for FCN2: Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) Hs.54517 [show with all ESTs]Unigene Representative Sequence: AK0961122 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000291744(uc004cfg.1) ENST00000350339(uc004cfh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCN2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCN2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FCN2 (NM_004108) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCN2 |
Additional cDNA sequence: AK096112.1 AK290843.1 AK308476.1 BC069572.1 BC069825.1 BC113935.1 D49353.1 3 DOTS entries: DT.100655023 DT.40257785 DT.91752978 18 AceView cDNA sequences: BC069825 BC069572 BX098225 AK096112 BX489605 AI052239 NM_015837 BX494192 NM_004108 D49353 BX104860 AI078046 NM_015838 NM_015839 H62841 H62842 H62781 AI056206
GeneLoc Exon Structure
|
Expression
for FCN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGTGATTCT
About this image
See FCN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCN2
SOURCE GeneReport for Unigene cluster: Hs.54517
UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485Tissue specificity: Expressed by the liver and secreted in plasma
SABiosciences Custom PCR Arrays for FCN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCN2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN2 |
Orthologs
for FCN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FCN2 gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FCN21 |
ficolin (collagen/fibrinogen domain containing lectin) more |
66.54(n)
64.09(a) |
|
417298 XM_415571.3 XP_415571.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
AB091342.12 |
-- |
75.54(n) |
|
AB091342.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG302803 |
-- |
44(a)
(best of 8) |
|
-- |
ENSEMBL Gene Tree for FCN2 (if available)
TreeFam Gene Tree for FCN2 (if available) |
Paralogs
for FCN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCN2 gene
- TNR2 FIBCD12 FCN32 FCN12 TNXB2 TNN2 MFAP42 FN12
- TNC2 ANGPTL52
18/40 SIMAP similar genes for FCN2 using alignment to 2 protein entries: FCN2_HUMAN (see all proteins)
(see all similar genes):FCN1 DKFZp781B1032 ANGPTL7 FCN3 FIBCD1 TNN
TNR TNC TNC variant protein ANGPT1 ANGPT4 ANGPTL2
COL9A1 TNXB MFAP4 FGL1 LFIRE1 ANGPTL4
FCN2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FCN2
PGOHUM00000236787
|
Genomic Variants
for FCN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCN2 (137772654 - 137779924 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FCN2: --
Human Gene Mutation Database (HGMD): FCN2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCN2 |
|
Disorders
/ Diseases
for FCN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCN2 for disorders About GeneDecksing
OMIM gene information: 601624
OMIM disorders: --
16  diseases for FCN2: About MalaCardsrheumatic fever bronchiectasis cystic fibrosis behcet's disease
pemphigus rheumatoid arthritis leprosy hepatitis b
gout sarcoidosis fibrosis arthritis
peritonitis nephropathy hepatitis malaria
Human Genome Epidemiology (HuGE) Navigator: FCN2 (13 documents)
Export disorders for FCN2 gene to outside databases
|
Publications
for FCN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCN2 gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with FCN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of the human lectin P35 gene and its related gene. (PubMed id 8884275)1, 2, 3, 9 Endo Y.... Fujita T. (1996)
- A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. (PubMed id 8576206)1, 2, 9 Matsushita M.... Mizuochi T. (1996)
- Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins. (PubMed id 7498469)1, 2, 9 Edgar P.F. (1995)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. (PubMed id 17680820)1, 9 Cedzynski M....Kilpatrick D.C. (2007)
- Ficolin 2 (FCN2) functional polymorphisms and the ris k of rheumatic fever and rheumatic heart disease. (PubMed id 19664148)1, 9 Messias-Reason I.J....Kun J.F. (2009)
- Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. (PubMed id 18950864)1, 9 St Swierzko A....Kilpatrick D.C. (2008)
- The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels. (PubMed id 17386030)1, 9 Munthe-Fog L....Garred P. (2007)
- Synergy between ficolin-2 and pentraxin 3 boosts inna te immune recognition and complement deposition. (PubMed id 19632990)1, 9 Ma Y.J....Garred P. (2009)
- Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease. (PubMed id 17382393)1, 9 Chapman S.J....Hill A.V. (2007)
|
External Searches for FCN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCN2 gene:
Search GeneIP for patents involving FCN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN2 |
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