Aliases for FCN2 Gene
External Ids for FCN2 Gene
Previous GeneCards Identifiers for FCN2 Gene
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for FCN2 Gene
FCN2 (Ficolin 2) is a Protein Coding gene. Diseases associated with FCN2 include progressive relapsing multiple sclerosis and rheumatic fever. Among its related pathways are Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is TNC.
UniProtKB/Swiss-Prot for FCN2 Gene
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.