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FCN2 Gene(Protein Coding)

Ficolin 2

GCID:
GC09P134864
GIFtS:
59
Genes Participants
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Aliases for FCN2 Gene

Aliases for FCN2 Gene

  • Ficolin 2 2 3 5
  • Collagen/Fibrinogen Domain-Containing Protein 2 2 3 4
  • Serum Lectin P35 2 3 4
  • L-Ficolin 2 3 4
  • 37 KDa Elastin-Binding Protein 3 4
  • Ficolin-Beta 3 4
  • Ficolin B 2 3
  • Hucolin 2 4
  • EBP-37 3 4
  • FCNL 3 4
  • Ficolin (Collagen/Fibrinogen Domain-Containing Lectin) 2 (Hucolin) 2
  • Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin) 3
  • Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 2
  • Ficolin-2 3
  • Ficolin-B 4
  • P35 3

External Ids for FCN2 Gene

Previous GeneCards Identifiers for FCN2 Gene

  • GC09P128922
  • GC09P129541
  • GC09P131295
  • GC09P133211
  • GC09P134998
  • GC09P136912
  • GC09P137772
  • GC09P107236

Summaries for FCN2 Gene

Entrez Gene Summary for FCN2 Gene

  • The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCN2 Gene

FCN2 (Ficolin 2) is a Protein Coding gene. Diseases associated with FCN2 include Adenoiditis and Progressive Relapsing Multiple Sclerosis. Among its related pathways are Innate Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is FCN1.

UniProtKB/Swiss-Prot for FCN2 Gene

  • May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.

Gene Wiki entry for FCN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCN2 Gene

Genomics for FCN2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FCN2 Gene

Enhancers for FCN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G134936 1.3 Ensembl ENCODE dbSUPER 11.7 +72.9 72945 2.2 PKNOX1 BMI1 GLIS2 RELB IKZF2 CREM MIER1 CBFB GATAD2B REST FCN2 COL5A1 FCN1 LOC105376314 LOC105376313
GH09G134669 1.4 Ensembl ENCODE dbSUPER 10.7 -193.4 -193389 2.8 PKNOX1 FOXA2 NFIB SIN3A BRCA1 ZNF121 GATA2 ZNF366 SMARCC2 RCOR1 COL5A1 FCN2 COL5A1-AS1 GC09P134726
GH09G134805 1.2 ENCODE dbSUPER 11.2 -54.8 -54758 7.7 HDGF PKNOX1 FEZF1 ZNF2 CBX5 ZNF202 TSHZ1 REST ZNF518A ZNF585B FCN2 FCN1 PPP1R26-AS1 COL5A1 RXRA MIR3689C GC09P134769
GH09G134922 1 FANTOM5 Ensembl dbSUPER 11.9 +58.6 58645 1.2 CEBPB MAX MYC FCN2 FCN1 LOC105376314
GH09G134800 0.8 ENCODE dbSUPER 11.5 -63.0 -62973 0.7 GATA3 ZNF687 POLR2A SMARCA4 FCN2 FCN1 PPP1R26-AS1 COL5A1 GC09P134769 MIR3689C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCN2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FCN2 gene promoter:

Genomic Location for FCN2 Gene

Chromosome:
9
Start:
134,864,156 bp from pter
End:
134,889,286 bp from pter
Size:
25,131 bases
Orientation:
Plus strand

Genomic View for FCN2 Gene

Genes around FCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCN2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FCN2 Gene

Proteins for FCN2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15485-FCN2_HUMAN
    Recommended name:
    Ficolin-2
    Protein Accession:
    Q15485
    Secondary Accessions:
    • A6NFG7
    • A8K478
    • Q6IS69
    • Q7M4P4
    • Q9UC57

    Protein attributes for FCN2 Gene

    Size:
    313 amino acids
    Molecular mass:
    34001 Da
    Quaternary structure:
    • Homotrimer (PubMed:17215869). Interacts with elastin. Interacts with MASP1 and MASP2.

    Three dimensional structures from OCA and Proteopedia for FCN2 Gene

    Alternative splice isoforms for FCN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCN2 Gene

Protein Expression for FCN2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FCN2 Gene

  • Glycosylation at isoforms=2240 and isoforms=2300

Other Protein References for FCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCN2 Gene

Domains & Families for FCN2 Gene

Gene Families for FCN2 Gene

HGNC:

Protein Domains for FCN2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15485

UniProtKB/Swiss-Prot:

FCN2_HUMAN :
  • The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.
  • Belongs to the ficolin lectin family.
Domain:
  • The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.
Family:
  • Belongs to the ficolin lectin family.
genes like me logo Genes that share domains with FCN2: view

Function for FCN2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FCN2 Gene

GENATLAS Biochemistry:
ficolin 2 (ficolin/opronin p35) lectin family,TGFB1 binding protein P35,expressed in liver
UniProtKB/Swiss-Prot Function:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.

Gene Ontology (GO) - Molecular Function for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IDA 8576206
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 19632990
GO:0030246 carbohydrate binding IEA --
GO:0043394 proteoglycan binding IDA 8576206
genes like me logo Genes that share ontologies with FCN2: view

Phenotypes for FCN2 Gene

GenomeRNAi human phenotypes for FCN2:
genes like me logo Genes that share phenotypes with FCN2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCN2 Gene

Localization for FCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCN2 gene
Compartment Confidence
extracellular 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0070062 extracellular exosome IDA 19056867
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with FCN2: view

Pathways & Interactions for FCN2 Gene

genes like me logo Genes that share pathways with FCN2: view

Gene Ontology (GO) - Biological Process for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006956 complement activation TAS --
GO:0008228 opsonization IDA 8576206
genes like me logo Genes that share ontologies with FCN2: view

No data available for SIGNOR curated interactions for FCN2 Gene

Drugs & Compounds for FCN2 Gene

Products:

  1. Drug

(2) Drugs for FCN2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(6) Additional Compounds for FCN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCN2: view

Transcripts for FCN2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FCN2 Gene

(6) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCN2 Gene

Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCN2 Gene

No ASD Table

Relevant External Links for FCN2 Gene

GeneLoc Exon Structure for
FCN2
ECgene alternative splicing isoforms for
FCN2

Expression for FCN2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCN2 Gene

mRNA expression in normal human tissues for FCN2 Gene
mRNA expression by BioGPS for FCN2 GenemRNA expression by GTEx for FCN2 Gene

mRNA differential expression in normal tissues according to GTEx for FCN2 Gene

This gene is overexpressed in Liver (x28.5) and Adrenal Gland (x9.1).

Protein differential expression in normal tissues from HIPED for FCN2 Gene

This gene is overexpressed in Serum (52.3) and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCN2 Gene



Protein tissue co-expression partners for FCN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCN2 Gene:

FCN2

SOURCE GeneReport for Unigene cluster for FCN2 Gene:

Hs.54517

mRNA Expression by UniProt/SwissProt for FCN2 Gene:

Q15485-FCN2_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for FCN2 Gene

  • Liver(4.5)
  • Bone marrow(4.1)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with FCN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCN2 Gene

Orthologs for FCN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FCN2 34 35
  • 98.4 (n)
dog
(Canis familiaris)
 Mammalia -- 35
  • 71 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Fcnb 35
  • 68 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 64 (a)
 ManyToMany
-- 35
  • 63 (a)
 ManyToMany
cow
(Bos Taurus)
 Mammalia FCNB 35
  • 60 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 53 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves -- 35
  • 57 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 41 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG30280 36
  • 44 (a)
CG30281 36
  • 44 (a)
CG5550 36
  • 44 (a)
CG1791 36
  • 42 (a)
CG8642 36
  • 42 (a)
CG9500 36
  • 42 (a)
sca 36
  • 42 (a)
CG10359 36
  • 37 (a)
CG41520 35
  • 16 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 49 (a)
 ManyToMany
-- 35
  • 46 (a)
 ManyToMany
-- 35
  • 44 (a)
 ManyToMany
-- 35
  • 43 (a)
 ManyToMany
Species where no ortholog for FCN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCN2 Gene

ENSEMBL:
Gene Tree for FCN2 (if available)
TreeFam:
Gene Tree for FCN2 (if available)

Paralogs for FCN2 Gene

Paralogs for FCN2 Gene

(39) SIMAP similar genes for FCN2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FCN2 Gene

genes like me logo Genes that share paralogs with FCN2: view

Variants for FCN2 Gene

Sequence variations from dbSNP and Humsavar for FCN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036342 A colorectal cancer sample
rs1000145286 -- 134,865,027(+) GCTGG(C/T)GGGCA intron-variant
rs1000219027 -- 134,867,538(+) TAATG(A/C)TAGAT intron-variant
rs1000245704 -- 134,862,723(+) TCCAC(A/G)GTATT intron-variant, upstream-variant-2KB
rs1000264962 -- 134,886,694(+) TCTCT(A/G)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCN2 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1043726 CNV gain 25217958
nsv1125319 OTHER inversion 24896259
nsv831753 CNV loss 17160897
nsv951815 CNV deletion 24416366

Variation tolerance for FCN2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.58; 94.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCN2 Gene

Human Gene Mutation Database (HGMD)
FCN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCN2 Gene

Disorders for FCN2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FCN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adenoiditis
  • chronic adenoiditis
progressive relapsing multiple sclerosis
  • prms
rheumatic fever
  • acute rheumatic fever
- elite association - COSMIC cancer census association via MalaCards
Search FCN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCN2

Genetic Association Database (GAD)
FCN2
Human Genome Epidemiology (HuGE) Navigator
FCN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCN2
genes like me logo Genes that share disorders with FCN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCN2 Gene

Publications for FCN2 Gene

  1. Cloning and characterization of the human lectin P35 gene and its related gene. (PMID: 8884275) Endo Y. … Fujita T. (Genomics 1996) 2 3 4 22 64
  2. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. (PMID: 19664148) Messias-Reason I.J. … Kun J.F. (Clin. Exp. Immunol. 2009) 3 22 46 64
  3. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PMID: 19220833) Ruskamp J.M. … Sanders E.A. (Clin. Exp. Immunol. 2009) 3 22 46 64
  4. Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (PMID: 19434912) de Messias-Reason I. … Kun J.F. (J. Infect. Dis. 2009) 3 22 46 64
  5. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PMID: 18032536) Vander Cruyssen B. … De Keyser F. (Rheumatology (Oxford) 2007) 3 22 46 64

Products for FCN2 Gene

Sources for FCN2 Gene

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