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FCN2 Gene

protein-coding   GIFtS: 65
GCID: GC09P137772

Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2

(Previous name: ficolin (collagen/fibrinogen domain-containing lectin) 2...)
  See FCN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 21 2     hucolin1
L-ficolin1 2 3     P352
Collagen/Fibrinogen Domain-Containing Protein 21 2 3     Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin)2
Serum Lectin P351 2 3     ficolin-22
Ficolin B1 2     ficolin-B2
37 KDa Elastin-Binding Protein2 3     ficolin-beta2
EBP-372 3     Ficolin-B3
FCNL2 3     Ficolin-beta3
Ficolin (Collagen/Fibrinogen Domain-Containing Lectin) 2 (Hucolin)1     Hucolin3

External Ids:    HGNC: 36241   Entrez Gene: 22202   Ensembl: ENSG000001603397   OMIM: 6016245   UniProtKB: Q154853   

Export aliases for FCN2 gene to outside databases

Previous GC identifers: GC09P128922 GC09P129541 GC09P131295 GC09P133211 GC09P134998 GC09P136912 GC09P107236


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCN2 Gene:
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence
of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal
fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have
carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different
isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FCN2 Gene:
FCN2 (ficolin (collagen/fibrinogen domain containing lectin) 2) is a protein-coding gene. Diseases associated with FCN2 include cutaneous leishmaniasis, and rheumatic fever. GO annotations related to this gene include antigen binding and calcium ion binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485
Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect
via the collagen region

Gene Wiki entry for FCN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCN2 gene promoter:
         AREB6   USF1   p53   USF-1   YY1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCN2 promoter sequence
   Search Chromatin IP Primers for FCN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

FCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCN2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P137772:  view genomic region     (about GC identifiers)

Start:
137,772,654 bp from pter      End:
137,779,924 bp from pter
Size:
7,271 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485 (See protein sequence)
Recommended Name: Ficolin-2 precursor  
Size: 313 amino acids; 34001 Da
Subunit: Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2
Selected PDB 3D structures from and Proteopedia for FCN2 (see all 10):
2J0G (3D)        2J0H (3D)        2J0Y (3D)        2J1G (3D)        2J2P (3D)        2J3F (3D)    
Secondary accessions: A6NFG7 A8K478 Q6IS69 Q7M4P4 Q9UC57
Alternative splicing: 2 isoforms:  Q15485-1   Q15485-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCN2: NX_Q15485

Explore proteomics data for FCN2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn240, Asn300

  • See FCN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004099.2  NP_056652.1  

    ENSEMBL proteins: 
     ENSP00000291744   ENSP00000291741  
    Reactome Protein details: Q15485

    FCN2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q15485

    ProtoNet protein and cluster: Q15485

    2 Blocks protein domains:
    IPB002181 Fibrinogen
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485
    Domain: The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in
    carbohydrate binding
    Similarity: Belongs to the ficolin lectin family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 fibrinogen C-terminal domain


    Find genes that share domains with FCN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCN2_HUMAN, Q15485
    Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
    and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect
    via the collagen region

         Genatlas biochemistry entry for FCN2:
    ficolin 2 (ficolin/opronin p35) lectin family,TGFB1 binding protein P35,expressed in liver

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS8576206
    GO:0005509calcium ion binding TAS8576206
    GO:0005515protein binding IPI--
    GO:0030246carbohydrate binding TAS8576206
    GO:0048306calcium-dependent protein binding IPI12421953
         
    Find genes that share ontologies with FCN2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCN2
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    miRNA
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    hsa-mir-26b-5p (MIRT029624)

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    Sino Biological Human cDNA Clone for FCN2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCN2_HUMAN, Q15485: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with FCN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Ficolins bind to repetitive carbohydrate structures on the target cell surface0.00
    Initial triggering of complement0.85
    Lectin pathway of complement activation0.00
    Complement cascade0.68
    2Complement Pathway
    Immune response Lectin Induced complement pathway0.56


    Find genes that share SuperPaths with FCN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FCN2
        Immune response Lectin induced complement pathway


    3 Reactome Pathways for FCN2
        Ficolins bind to repetitive carbohydrate structures on the target cell surface
    Lectin pathway of complement activation
    Initial triggering of complement


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCN2
    Interactions:

        GeneGlobe Interaction Network for FCN2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for FCN2 (Q154851, 2, 3 ENSP000002917444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP1Q079541, 2, 3, ENSP000002430774EBI-7468784,EBI-1046087 MINT-8040880 MINT-8040690 I2D: score=1 STRING: ENSP00000243077
    CRPP027412, 3, ENSP000002550304MINT-5223188 I2D: score=2 STRING: ENSP00000255030
    MASP1P487403, ENSP000002962804I2D: score=2 STRING: ENSP00000296280
    MASP2O001873, ENSP000003836904I2D: score=2 STRING: ENSP00000383690
    PTX3P260223I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001867complement activation, lectin pathway TAS--
    GO:0006956complement activation TAS--
    GO:0008228opsonization TAS8576206
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with FCN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCN2

    1 HMDB Compound for FCN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 Novoseek inferred chemical compound relationships for FCN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 62.3 10 19699205 (1), 16305643 (1), 16644773 (1), 19334557 (1) (see all 9)
    mannan 59.7 4 10232391 (2), 19234189 (1)
    n-acetylglucosamine 51.6 4 15879437 (1), 20032467 (1), 15611266 (1)
    1,3-beta-d-glucan 49.9 1 15078867 (1)
    polysaccharide 39.7 6 17680820 (1), 20032467 (1), 18486240 (1)
    sialic acid 29.5 6 20032467 (2), 17938215 (2)
    fibrinogen 12.4 1 20032467 (1)



    Find genes that share compounds with FCN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCN2 gene (4 alternative transcripts): 
    NM_004108.2  NM_015837.2  NM_015838.1  NM_015839.1  

    Unigene Cluster for FCN2:

    Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
    Hs.54517  [show with all ESTs]
    Unigene Representative Sequence: AK096112
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291744(uc004cfg.1) ENST00000350339(uc004cfh.1)
    miRNA
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    Additional mRNA sequence: 

    AK096112.1 AK290843.1 AK308476.1 BC069572.1 BC069825.1 BC113935.1 D49353.1 

    3 DOTS entries:

    DT.100655023  DT.40257785  DT.91752978 

    18 AceView cDNA sequences:

    BC069572 BC069825 BX098225 D49353 BX489605 NM_015837 BX104860 AI052239 
    BX494192 AK096112 NM_004108 NM_015838 AI078046 NM_015839 H62841 H62842 
    AI056206 H62781 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGTGATTCT
    FCN2 Expression
    About this image

    FCN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.54517

    UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485
    Tissue specificity: Expressed by the liver and secreted in plasma

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FCN2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    57(a)
    1 → many
    17(276902-284362)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    41(a)
    many ↔ many
    1(77109117-77117483)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB091342.12   -- 75.54(n)    AB091342.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG302803   -- 44(a)
    (best of 8)
        --
            Species with no ortholog for FCN2

    ENSEMBL Gene Tree for FCN2 (if available)
    TreeFam Gene Tree for FCN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCN2 gene
    FGL22  ANGPT42  FGG2  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN12  
    ANGPT12  ANGPTL12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    Selected SIMAP similar genes for FCN2 using alignment to 2 protein entries:     FCN2_HUMAN (see all proteins) (see all similar genes):
    FCN1    DKFZp781B1032    ANGPTL7    FCN3    FIBCD1    TNN
    TNR    TNC    TNC variant protein    ANGPT1    ANGPT4    ANGPTL2
    COL9A1    TNXB    MFAP4    FGL1    LFIRE1    COL1A2

    Find genes that share paralogs with FCN2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FCN2
    PGOHUM00000236787


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCN2 (see all 360)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363424
    A colorectal cancer sample4--see VAR_0363422 P L mis40--------
    rs679111891,2
    C--137775448(+) GTGTAG/-GGGGG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs114451301,2
    C--137775825(+) GGGGGG/-ATTGT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1389826631,2
    C--137805453(+) AACTCC/TGTCTC 2 -- us2k10--------
    rs43500501,2
    C,F,H--137805486(+) AGCTGC/TATTCT 2 -- us2k110Minor allele frequency- T:0.10NS EA NA 1156
    rs747064121,2
    C,F--137805615(+) AAACAT/CTGTTA 2 -- us2k11Minor allele frequency- C:0.13WA 118
    rs1814295991,2
    --137805647(+) AACCAA/CATTTA 2 -- us2k10--------
    rs1147543311,2
    C,F--137805672(+) GTCTAA/TCTTTA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs31286281,2
    C,F,A,H--137805708(-) TTACAT/CTTCTA 2 -- us2k123Minor allele frequency- C:0.33NA NS EA CSA WA 2479
    rs1859111211,2
    --137805849(+) AGTTAC/TCCTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCN2 (137772654 - 137779924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FCN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv894199CNV Loss21882294
    nsv831753CNV Loss17160897
    nsv894195CNV Gain21882294

    Human Gene Mutation Database (HGMD): FCN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCN2
    DNA2.0 Custom Variant and Variant Library Synthesis for FCN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601624    OMIM disorders: --

    3 diseases for FCN2:    
    About MalaCards
    cutaneous leishmaniasis    rheumatic fever    rheumatic heart disease


    Find genes that share disorders with FCN2           About GenesLikeMe

    Genetic Association Database (GAD): FCN2
    Human Genome Epidemiology (HuGE) Navigator: FCN2 (13 documents)

    Export disorders for FCN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCN2 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with FCN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human lectin P35 gene and its related gene. (PubMed id 8884275)1, 2, 3, 9 Endo Y.... Fujita T. (Genomics 1996)
    2. Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. (PubMed id 17680820)1, 4, 9 Cedzynski M....Kilpatrick D.C. (Clin. Exp. Immunol. 2007)
    3. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. (PubMed id 19664148)1, 4, 9 Messias-Reason I.J....Kun J.F. (Clin. Exp. Immunol. 2009)
    4. Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease. (PubMed id 17382393)1, 4, 9 Chapman S.J....Hill A.V. (Mol. Immunol. 2007)
    5. A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. (PubMed id 8576206)1, 2, 9 Matsushita M.... Mizuochi T. (J. Biol. Chem. 1996)
    6. Single nucleotide polymorphisms of Ficolin 2 gene in BehAset's disease. (PubMed id 16839748)1, 4, 9 Chen X....Mizuki N. (J. Dermatol. Sci. 2006)
    7. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PubMed id 19220833)1, 4, 9 Ruskamp J.M....Sanders E.A. (Clin. Exp. Immunol. 2009)
    8. Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (PubMed id 19434912)1, 4, 9 de Messias-Reason I....Kun J.F. (J. Infect. Dis. 2009)
    9. Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins. (PubMed id 7498469)1, 2, 9 Edgar P.F. (FEBS Lett. 1995)
    10. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PubMed id 18032536)1, 4, 9 Vander Cruyssen B....De Keyser F. (Rheumatology (Oxford) 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2220 HGNC: 3624 AceView: FCN2 Ensembl:ENSG00000160339 euGenes: HUgn2220
    ECgene: FCN2 H-InvDB: FCN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FCN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FCN2 gene:
    Search GeneIP for patents involving FCN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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