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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCN2 Gene

protein-coding   GIFtS: 65
GCID: GC09P137772

Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2

(Previous name: ficolin (collagen/fibrinogen domain-containing lectin) 2...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 21 2     hucolin1
L-ficolin1 2 3     P352
Collagen/Fibrinogen Domain-Containing Protein 21 2 3     Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin)2
Serum Lectin P351 2 3     ficolin-22
Ficolin B1 2     ficolin-B2
37 KDa Elastin-Binding Protein2 3     ficolin-beta2
EBP-372 3     Ficolin-B3
FCNL2 3     Ficolin-beta3
Ficolin (Collagen/Fibrinogen Domain-Containing Lectin) 2 (Hucolin)1     Hucolin3

External Ids:    HGNC: 36241   Entrez Gene: 22202   Ensembl: ENSG000001603397   OMIM: 6016245   UniProtKB: Q154853   

Export aliases for FCN2 gene to outside databases

Previous GC identifers: GC09P128922 GC09P129541 GC09P131295 GC09P133211 GC09P134998 GC09P136912 GC09P107236


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCN2 Gene:
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence
of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal
fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have
carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different
isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FCN2 Gene: 
FCN2 (ficolin (collagen/fibrinogen domain containing lectin) 2) is a protein-coding gene. Diseases associated with FCN2 include rheumatic fever, and bronchiectasis, and among its related super-pathways are Immune response Alternative complement pathway and Classical antibody-mediated complement activation. GO annotations related to this gene include carbohydrate binding and calcium ion binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485
Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect
via the collagen region

Gene Wiki entry for FCN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_019501.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCN2 gene promoter:
         AREB6   USF1   p53   USF-1   YY1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FCN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

FCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCN2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P137772:  view genomic region     (about GC identifiers)

Start:
137,772,654 bp from pter      End:
137,779,924 bp from pter
Size:
7,271 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485 (See protein sequence)
Recommended Name: Ficolin-2 precursor  
Size: 313 amino acids; 34001 Da
Subunit: Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2
Subcellular location: Secreted
6/10 PDB 3D structures from and Proteopedia for FCN2 (see all 10):
2J0G (3D)        2J0H (3D)        2J0Y (3D)        2J1G (3D)        2J2P (3D)        2J3F (3D)    
Secondary accessions: A6NFG7 A8K478 Q6IS69 Q7M4P4 Q9UC57
Alternative splicing: 2 isoforms:  Q15485-1   Q15485-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCN2: NX_Q15485

Explore proteomics data for FCN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15485

  • FCN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FCN2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004099.2  NP_056652.1  

    ENSEMBL proteins: 
     ENSP00000291744   ENSP00000291741  
    Reactome Protein details: Q15485
    Human Recombinant Protein Products for FCN2: 
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    Novus Biologicals FCN2 Protein
    Novus Biologicals FCN2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FCN2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--

    FCN2 for ontologies           About GeneDecksing



    FCN2 Antibody Products: 
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    Abcam antibodies for FCN2
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    ThermoFisher Antibodies for FCN2
    LSBio Antibodies in human, mouse, rat for FCN2 

    Assay Products for FCN2: 
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    Cloud-Clone Corp. ELISAs for FCN2 
    Cloud-Clone Corp. CLIAs for FCN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q15485

    ProtoNet protein and cluster: Q15485

    2 Blocks protein domains:
    IPB002181 Fibrinogen
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485
    Domain: The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in
    carbohydrate binding
    Similarity: Belongs to the ficolin lectin family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 fibrinogen C-terminal domain


    FCN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCN2_HUMAN, Q15485
    Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent
    and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect
    via the collagen region

         Genatlas biochemistry entry for FCN2:
    ficolin 2 (ficolin/opronin p35) lectin family,TGFB1 binding protein P35,expressed in liver

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS8576206
    GO:0005509calcium ion binding TAS8576206
    GO:0005515protein binding IPI--
    GO:0030246carbohydrate binding TAS8576206
    GO:0048306calcium-dependent protein binding IPI12421953
         
    FCN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FCN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FCN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCN2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FCN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Lectin Induced complement pathway0.56
    2Classical antibody-mediated complement activation
    Creation of C4 and C2 activators0.88
    Complement cascade0.76
    Initial triggering of complement0.86
    3Ficolins bind to repetitive carbohydrate structures on the target cell surface
    Ficolins bind to repetitive carbohydrate structures on the target cell surface0.83
    Lectin pathway of complement activation0.83
    4Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FCN2
        Immune response Lectin Induced complement pathway


    1 GeneGo (Thomson Reuters) Pathway for FCN2
        Immune response Lectin induced complement pathway


    5/7        Reactome Pathways for FCN2 (see all 7)
        Creation of C4 and C2 activators
    Ficolins bind to repetitive carbohydrate structures on the target cell surface
    Lectin pathway of complement activation
    Complement cascade
    Immune System



    FCN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCN2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for FCN2 (Q154852, 3 ENSP000002917444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP1Q079542, 3, ENSP000002430774MINT-8040880 MINT-8040690 I2D: score=1 STRING: ENSP00000243077
    CRPP027412, 3, ENSP000002550304MINT-5223188 I2D: score=2 STRING: ENSP00000255030
    MASP1P487403, ENSP000002962804I2D: score=2 STRING: ENSP00000296280
    MASP2O001873, ENSP000003836904I2D: score=2 STRING: ENSP00000383690
    PTX3P260223I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001867complement activation, lectin pathway TAS--
    GO:0006956complement activation TAS--
    GO:0008228opsonization TAS8576206
    GO:0045087innate immune response TAS--

    FCN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCN2

    1 HMDB Compound for FCN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 Novoseek inferred chemical compound relationships for FCN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 62.3 10 19699205 (1), 16305643 (1), 16644773 (1), 19334557 (1) (see all 9)
    mannan 59.7 4 10232391 (2), 19234189 (1)
    n-acetylglucosamine 51.6 4 15879437 (1), 20032467 (1), 15611266 (1)
    1,3-beta-d-glucan 49.9 1 15078867 (1)
    polysaccharide 39.7 6 17680820 (1), 20032467 (1), 18486240 (1)
    sialic acid 29.5 6 20032467 (2), 17938215 (2)
    fibrinogen 12.4 1 20032467 (1)

    Search CenterWatch for drugs/clinical trials and news about FCN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCN2 gene (4 alternative transcripts): 
    NM_004108.2  NM_015837.2  NM_015838.1  NM_015839.1  

    Unigene Cluster for FCN2:

    Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
    Hs.54517  [show with all ESTs]
    Unigene Representative Sequence: AK096112
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291744(uc004cfg.1) ENST00000350339(uc004cfh.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FCN2 (NM_004108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCN2
    Sirion Biotech Customized lentivirus for stable overexpression of FCN2 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCN2

    Additional mRNA sequence: 

    AK096112.1 AK290843.1 AK308476.1 BC069572.1 BC069825.1 BC113935.1 D49353.1 

    3 DOTS entries:

    DT.100655023  DT.40257785  DT.91752978 

    18 AceView cDNA sequences:

    BC069825 BC069572 BX098225 BX489605 D49353 NM_015837 AK096112 AI052239 
    BX494192 NM_004108 BX104860 NM_015839 NM_015838 AI078046 H62841 H62842 
    AI056206 H62781 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGTGATTCT
    FCN2 Expression
    About this image


    See FCN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCN2

    SOURCE GeneReport for Unigene cluster: Hs.54517

    UniProtKB/Swiss-Prot: FCN2_HUMAN, Q15485
    Tissue specificity: Expressed by the liver and secreted in plasma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FCN2 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FCN21 ficolin (collagen/fibrinogen domain containing lectin) more 66.54(n)
    64.09(a)
      417298  XM_415571.3  XP_415571.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    46(a)
    45(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    1(77130430-77139418)
    1(77119042-77127931)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB091342.12   -- 75.54(n)    AB091342.1 
            Species with no ortholog for FCN2

    ENSEMBL Gene Tree for FCN2 (if available)
    TreeFam Gene Tree for FCN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCN2 gene
    FGL22  ANGPT42  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN12  ANGPT12  
    ANGPTL12  ANGPTL72  ANGPT22  MFAP42  
    18/39 SIMAP similar genes for FCN2 using alignment to 2 protein entries:     FCN2_HUMAN (see all proteins) (see all similar genes):
    FCN1    DKFZp781B1032    ANGPTL7    FCN3    FIBCD1    TNN
    TNR    TNC    TNC variant protein    ANGPT1    ANGPT4    ANGPTL2
    COL9A1    TNXB    MFAP4    FGL1    LFIRE1    COL1A2

    FCN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FCN2
    PGOHUM00000236787


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/360 SNPs in FCN2 are shown (see all 360)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363424
    A colorectal cancer sample4--see VAR_0363422 P L mis40--------
    rs679111891,2
    C--137775448(+) GTGTAG/-GGGGG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs114451301,2
    C--137775825(+) GGGGGG/-ATTGT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1389826631,2
    C--137805453(+) AACTCC/TGTCTC 2 -- us2k10--------
    rs43500501,2
    C,F,H--137805486(+) AGCTGC/TATTCT 2 -- us2k110Minor allele frequency- T:0.10NS EA NA 1156
    rs747064121,2
    C,F--137805615(+) AAACAT/CTGTTA 2 -- us2k11Minor allele frequency- C:0.13WA 118
    rs1814295991,2
    --137805647(+) AACCAA/CATTTA 2 -- us2k10--------
    rs1147543311,2
    C,F--137805672(+) GTCTAA/TCTTTA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs31286281,2
    C,F,A,H--137805708(-) TTACAT/CTTCTA 2 -- us2k123Minor allele frequency- C:0.33NA NS EA CSA WA 2479
    rs1859111211,2
    --137805849(+) AGTTAC/TCCTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCN2 (137772654 - 137779924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FCN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv894199CNV Loss21882294
    nsv831753CNV Loss17160897
    nsv894195CNV Gain21882294


    Human Gene Mutation Database (HGMD): FCN2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FCN2
    DNA2.0 Custom Variant and Variant Library Synthesis for FCN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601624    OMIM disorders: --

    19 diseases for FCN2:    About MalaCards
    rheumatic fever    bronchiectasis    gout    leprosy
    behcet's disease    cutaneous leishmaniasis    pemphigus    peritonitis
    schistosomiasis    sarcoidosis    leishmaniasis    malaria
    cystic fibrosis    pre-eclampsia    eclampsia    hepatitis b
    rheumatoid arthritis    arthritis    hepatitis


    FCN2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): FCN2
    Human Genome Epidemiology (HuGE) Navigator: FCN2 (13 documents)

    Export disorders for FCN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCN2 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with FCN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human lectin P35 gene and its related gene. (PubMed id 8884275)1, 2, 3, 9 Endo Y.... Fujita T. (1996)
    2. Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. (PubMed id 17680820)1, 4, 9 Cedzynski M....Kilpatrick D.C. (2007)
    3. Ficolin 2 (FCN2) functional polymorphisms and the ris k of rheumatic fever and rheumatic heart disease. (PubMed id 19664148)1, 4, 9 Messias-Reason I.J....Kun J.F. (2009)
    4. Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease. (PubMed id 17382393)1, 4, 9 Chapman S.J....Hill A.V. (2007)
    5. A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. (PubMed id 8576206)1, 2, 9 Matsushita M.... Mizuochi T. (1996)
    6. Single nucleotide polymorphisms of Ficolin 2 gene in Behcet's disease. (PubMed id 16839748)1, 4, 9 Chen X....Mizuki N. (2006)
    7. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PubMed id 19220833)1, 4, 9 Ruskamp J.M....Sanders E.A. (2009)
    8. Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (PubMed id 19434912)1, 4, 9 de Messias-Reason I....Kun J.F. (2009)
    9. Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins. (PubMed id 7498469)1, 2, 9 Edgar P.F. (1995)
    10. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PubMed id 18032536)1, 4, 9 Vander Cruyssen B....De Keyser F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2220 HGNC: 3624 AceView: FCN2 Ensembl:ENSG00000160339 euGenes: HUgn2220
    ECgene: FCN2 H-InvDB: FCN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCN2 gene:
    Search GeneIP for patents involving FCN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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