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Aliases for FCN1 Gene

Aliases for FCN1 Gene

  • Ficolin (Collagen/Fibrinogen Domain Containing) 1 2 3
  • Ficolin (Collagen/Fibrinogen Domain-Containing) 1 2 3
  • Collagen/Fibrinogen Domain-Containing Protein 1 3 4
  • Ficolin-Alpha 3 4
  • Ficolin-A 3 4
  • M-Ficolin 3 4
  • FCNM 3 4
  • Ficolin-1 3

External Ids for FCN1 Gene

Previous GeneCards Identifiers for FCN1 Gene

  • GC09M128951
  • GC09M129570
  • GC09M131324
  • GC09M133240
  • GC09M135027
  • GC09M136940
  • GC09M137801
  • GC09M107265

Summaries for FCN1 Gene

Entrez Gene Summary for FCN1 Gene

  • The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCN1 Gene

FCN1 (Ficolin (Collagen/Fibrinogen Domain Containing) 1) is a Protein Coding gene. Among its related pathways are Creation of C4 and C2 activators and Creation of C4 and C2 activators. GO annotations related to this gene include calcium ion binding and antigen binding. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for FCN1 Gene

  • Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Gene Wiki entry for FCN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCN1 Gene

Genomics for FCN1 Gene

Regulatory Elements for FCN1 Gene

Genomic Location for FCN1 Gene

Start:
134,905,865 bp from pter
End:
134,918,003 bp from pter
Size:
12,139 bases
Orientation:
Minus strand

Genomic View for FCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCN1 Gene

Proteins for FCN1 Gene

  • Protein details for FCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00602-FCN1_HUMAN
    Recommended name:
    Ficolin-1
    Protein Accession:
    O00602
    Secondary Accessions:
    • Q5VYV5
    • Q92596

    Protein attributes for FCN1 Gene

    Size:
    326 amino acids
    Molecular mass:
    35078 Da
    Quaternary structure:
    • Homotrimer. Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.
    SequenceCaution:
    • Sequence=BAA12120.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCN1 Gene

neXtProt entry for FCN1 Gene

Proteomics data for FCN1 Gene at MOPED

Post-translational modifications for FCN1 Gene

  • Glycosylation at Asn305
  • Modification sites at PhosphoSitePlus

Other Protein References for FCN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FCN1 Gene

Domains for FCN1 Gene

Gene Families for FCN1 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for FCN1 Gene

Graphical View of Domain Structure for InterPro Entry

O00602

UniProtKB/Swiss-Prot:

FCN1_HUMAN :
  • O00602
Domain:
  • The Fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability
  • Contains 1 collagen-like domain.
  • Contains 1 fibrinogen C-terminal domain.
Family:
  • Belongs to the ficolin lectin family.
genes like me logo Genes that share domains with FCN1: view

Function for FCN1 Gene

Molecular function for FCN1 Gene

GENATLAS Biochemistry: ficolin 1,TGFB1 binding protein,expressed in peripheral leukocytes and lung
UniProtKB/Swiss-Prot Function: Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Gene Ontology (GO) - Molecular Function for FCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 21037097
GO:0003823 antigen binding --
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 17581635
GO:0008329 signaling pattern recognition receptor activity IMP 21037097
genes like me logo Genes that share ontologies with FCN1: view

Phenotypes for FCN1 Gene

genes like me logo Genes that share phenotypes with FCN1: view

Animal Models for FCN1 Gene

MGI Knock Outs for FCN1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FCN1 Gene

Localization for FCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCN1 Gene

Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCN1 Gene COMPARTMENTS Subcellular localization image for FCN1 gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0031232 extrinsic component of external side of plasma membrane IDA 21037097
genes like me logo Genes that share ontologies with FCN1: view

Pathways for FCN1 Gene

genes like me logo Genes that share pathways with FCN1: view

Gene Ontology (GO) - Biological Process for FCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0002752 cell surface pattern recognition receptor signaling pathway IMP 21037097
GO:0006956 complement activation TAS --
GO:0007186 G-protein coupled receptor signaling pathway IDA 21037097
GO:0008228 opsonization --
genes like me logo Genes that share ontologies with FCN1: view

Compounds for FCN1 Gene

(3) Novoseek inferred chemical compound relationships for FCN1 Gene

Compound -log(P) Hits PubMed IDs
n-acetylglucosamine 71.5 2
serine 52.8 3
fibrinogen 22.1 1
genes like me logo Genes that share compounds with FCN1: view

Transcripts for FCN1 Gene

mRNA/cDNA for FCN1 Gene

(131) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCN1 Gene

Ficolin (collagen/fibrinogen domain containing) 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCN1 Gene

No ASD Table

Relevant External Links for FCN1 Gene

GeneLoc Exon Structure for
FCN1
ECgene alternative splicing isoforms for
FCN1

Expression for FCN1 Gene

mRNA expression in normal human tissues for FCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCN1 Gene

This gene is overexpressed in Whole Blood (46.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCN1 Gene

SOURCE GeneReport for Unigene cluster for FCN1 Gene Hs.440898

mRNA Expression by UniProt/SwissProt for FCN1 Gene

O00602-FCN1_HUMAN
Tissue specificity: Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes.
genes like me logo Genes that share expressions with FCN1: view

Orthologs for FCN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCN1 35
  • 98.26 (n)
  • 97.55 (a)
FCN1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCN1 35
  • 80.86 (n)
  • 77.78 (a)
FCNB 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
LOC608247 35
  • 78.34 (n)
  • 74.13 (a)
mouse
(Mus musculus)
Mammalia Fcna 16
Fcnb 35
  • 76.82 (n)
  • 75 (a)
Fcnb 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fcnb 35
  • 76.87 (n)
  • 76.97 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
FCN2 35
  • 64.04 (n)
  • 60.57 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC108470 35
  • 60.82 (n)
  • 60.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG41520 36
  • 16 (a)
OneToMany
CG5550 35
  • 52.82 (n)
  • 43.72 (a)
CG30281 37
  • 42 (a)
CG1791 37
  • 42 (a)
CG8642 37
  • 42 (a)
sca 37
  • 39 (a)
CG30280 37
  • 42 (a)
CG9500 37
  • 41 (a)
CG5550 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
Species with no ortholog for FCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCN1 Gene

ENSEMBL:
Gene Tree for FCN1 (if available)
TreeFam:
Gene Tree for FCN1 (if available)

Paralogs for FCN1 Gene

genes like me logo Genes that share paralogs with FCN1: view

Variants for FCN1 Gene

Sequence variations from dbSNP and Humsavar for FCN1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1071583 -- 134,909,954(+) GCTCC(C/T)TGGAA reference, synonymous-codon, intron-variant
rs1105323 -- 134,910,567(-) CACGC(A/G)TGACC intron-variant
rs1105324 -- 134,910,356(-) AGCGG(C/T)GCAGG intron-variant
rs1105325 -- 134,910,306(-) TGACA(C/G)TTTGC intron-variant
rs1128428 -- 134,909,834(-) TATAG(C/G)TACAA reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCN1 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894195 CNV Gain 21882294
nsv894199 CNV Loss 21882294
nsv831753 CNV Loss 17160897
nsv894203 CNV Gain 21882294
nsv825155 CNV Loss 20364138

Relevant External Links for FCN1 Gene

HapMap Linkage Disequilibrium report
FCN1
Human Gene Mutation Database (HGMD)
FCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCN1 Gene

Disorders for FCN1 Gene

Relevant External Links for FCN1

Genetic Association Database (GAD)
FCN1
Human Genome Epidemiology (HuGE) Navigator
FCN1
genes like me logo Genes that share disorders with FCN1: view

No data available for UniProtKB/Swiss-Prot for FCN1 Gene

Publications for FCN1 Gene

  1. Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. (PMID: 8947836) Harumiya S. … Ichijo H. (J. Biochem. 1996) 3 4 23
  2. Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. (PMID: 17148457) Tanio M. … Kohno T. (J. Biol. Chem. 2007) 3 4 23
  3. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PMID: 18032536) Vander Cruyssen B. … De Keyser F. (Rheumatology (Oxford) 2007) 3 23 48
  4. Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. (PMID: 20032467) Gout E. … Thielens N.M. (J. Biol. Chem. 2010) 3 4 23
  5. Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. (PMID: 8573080) Lu J. … Reid K.B. (Biochem. J. 1996) 2 3 4

Products for FCN1 Gene

Sources for FCN1 Gene

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