FCN1 Gene
protein-coding GIFtS: 55
GCID: GC09M137801
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ficolin (collagen/fibrinogen domain containing) 1(Previous name: ficolin (collagen/fibrinogen domain-containing) 1 )
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Aliases
for FCN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ficolin (Collagen/Fibrinogen Domain Containing) 11 2 | | Ficolin-11 | | FCNM1 2 3 | | Ficolin-A3 | | Ficolin (Collagen/Fibrinogen Domain-Containing) 11 2 | | Ficolin-Alpha1 | | Collagen/Fibrinogen Domain-Containing Protein 12 3 | | Ficolin-A3 | | M-Ficolin1 | | Ficolin-Alpha1 |
Export aliases for FCN1 gene to outside databasesPrevious GC identifers: GC09M128951 GC09M129570 GC09M131324 GC09M133240 GC09M135027 GC09M136940 GC09M107265 |
Summaries
for FCN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FCN1:
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment,followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-likedomains are also found separately in other proteins such as complement protein C1q, C-type lectins known ascollectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct.Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated tofunction as a plasma protein with elastin-binding activity. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602Function: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3linkage
Gene Wiki entry for FCN1
|
Genomic Views
for FCN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_019501.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCN1 gene promoter:
TBP STAT5B RP58 RREB-1 FOXD3 POU6F1 (c2) POU2F1 POU2F1a HSF2 SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34FCN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M137801: view genomic region
(about GC identifiers)
Start:
|
137,801,431 bp from pter |
End:
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137,809,809 bp from pter |
Size:
|
8,379 bases |
Orientation:
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minus strand |
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Proteins
for FCN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602 (See
protein sequence)Recommended Name: Ficolin-1 precursor Size: 326 amino acids; 35078 Da
Subunit: Homotrimer. Interacts with elastin
Subcellular location: Secreted. Note=Found on the monocyte and granulocyte surface
Sequence caution: Sequence=BAA12120.1; Type=Erroneous initiation;
6/7 PDB 3D structures from  and Proteopedia  for FCN1 (see all 7):2D39 (3D)
2JHH (3D)
2JHI (3D)
2JHK (3D)
2JHL (3D)
2JHM (3D)
Secondary accessions: Q5VYV5 Q92596Explore the universe of human proteins at neXtProt for FCN1: NX_O00602
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00602
FCN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001994.2
ENSEMBL proteins: ENSP00000360871
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FCN1 for ontologies About GeneDecksing
FCN1 Antibody Products:
Assay Products for FCN1: |
Protein
Domains /
Families
for FCN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCN1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00602ProtoNet protein and cluster: O00602 3 Blocks protein families: IPB002181 Fibrinogen IPB008160 Collagen triple helix repeat IPB008161 Collagen helix repeat
UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602Domain: The Fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cellsurface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses itscarbohydrate-binding abilitySimilarity: Belongs to the ficolin lectin familySimilarity: Contains 1 collagen-like domainSimilarity: Contains 1 fibrinogen C-terminal domain |
Function
for FCN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602Function: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3linkage Genatlas biochemistry entry for FCN1:ficolin 1,TGFB1 binding protein,expressed in peripheral leukocytes and lung
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCN1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
FCN1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Fcnatm1Tefu for FCN1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Fcna):
FCN1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FCN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCN1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/7 Interacting proteins for FCN1 (O006022, 3 ENSP000003608714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FCN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FCN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FCN1 for compounds About GeneDecksing
 Browse Tocris compounds for FCN1
3 Novoseek chemical compound relationships for FCN1 gene About this table
Search CenterWatch for drugs/clinical trials and news about FCN1
|
Transcripts
for FCN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCN1 gene: NM_002003.3 Unigene Cluster for FCN1: Ficolin (collagen/fibrinogen domain containing) 1 Hs.440898 [show with all ESTs]Unigene Representative Sequence: CR7494521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000371806(uc004cfi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCN1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FCN1 (NM_002003) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCN1 |
Additional cDNA sequence: AK314867.1 BC020635.1 CR749452.1 D83920.1 7 DOTS entries: DT.310006 DT.100750082 DT.121207883 DT.101970600 DT.91819193 DT.100737210 DT.99946928 24/131 AceView cDNA sequences (see all 131): AL597481 AI823478 BQ334624 AA496792 AI690204 CR615246 BM708133 BI030857 CA418940 BG236116 CD743208 BC020635 BF901668 AI765115 AL583593 BX643968 NM_002003 BG058611 AL708875 CA426283 BF899506 BQ184033 BX644677 BI763323
GeneLoc Exon Structure
|
Expression
for FCN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACAACCT
About this image
See FCN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCN1
SOURCE GeneReport for Unigene cluster: Hs.440898
UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602Tissue specificity: Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus,may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes
SABiosciences Expression via Pathway-Focused PCR Array including FCN1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCN1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN1 |
Orthologs
for FCN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FCN1 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FCN36 |
Uncharacterized protein |
59(a) |
1 → many |
17(656051-663265) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BQ734819.12 |
-- |
74.93(n) |
|
BQ734819.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG302803 |
-- |
42(a)
(best of 7) |
|
-- |
ENSEMBL Gene Tree for FCN1 (if available)
TreeFam Gene Tree for FCN1 (if available) |
Paralogs
for FCN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCN1 gene
- TNR2 FIBCD12 FCN32 FCN22 TNXB2 TNN2 MFAP42 FN12
- TNC2 ANGPTL52
18/23 SIMAP similar genes for FCN1 using alignment to 2 protein entries: FCN1_HUMAN (see all proteins)
(see all similar genes):DKFZp781B1032 FCN2 ANGPTL7 ANGPT1 ANGPTL2 FCN3
ANGPT4 LFIRE1 FGL1 TNXB TNR TNC
TNC variant protein ANGPT2 TNN FGG MFAP4 ANGPTL4
FCN1 for paralogs About GeneDecksing
|
Genomic Variants
for FCN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCN1 (137801431 - 137809809 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FCN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCN1 |
|
Disorders
/ Diseases
for FCN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCN1 for disorders About GeneDecksing
OMIM gene information: 601252
OMIM disorders: --
7  diseases for FCN1: About MalaCardschronic fatigue syndrome rheumatic fever rheumatoid arthritis hepatitis b
gout arthritis hepatitis
Human Genome Epidemiology (HuGE) Navigator: FCN1 (2 documents)
Export disorders for FCN1 gene to outside databases
|
Publications
for FCN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCN1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with FCN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. (PubMed id 8573080)1, 2, 3 Lu J.... Reid K.B. (1996)
- Carbohydrate recognition properties of human ficolins : glycan array screening reveals the sialic acid binding specificity of M-ficol in. (PubMed id 20032467)1, 2, 9 Gout E....Thielens N.M. (2010)
- Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. (PubMed id 8947836)1, 2, 9 Harumiya S.... Ichijo H. (1996)
- Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. (PubMed id 17148457)1, 2, 9 Tanio M....Kohno T. (2007)
- Tethering of Ficolin-1 to cell surfaces through recog nition of sialic acid by the fibrinogen-like domain. (PubMed id 20400674)1, 2 HonorAc C....Garred P. (2010)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of the human lectin P35 gene and its related gene. (PubMed id 8884275)1, 3 Endo Y.... Fujita T. (1996)
- Ficolin-1 is present in a highly mobilizable subset o f human neutrophil granules and associates with the cell surface after stimulat ion with fMLP. (PubMed id 19741154)1, 9 RA...Borregaard N. (2009)
- The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma. (PubMed id 18343499)1, 9 Honore C....Garred P. (2008)
|
External Searches for FCN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCN1 gene:
Search GeneIP for patents involving FCN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCN1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCN1 |
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