Aliases for FCN1 Gene
External Ids for FCN1 Gene
Previous GeneCards Identifiers for FCN1 Gene
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for FCN1 Gene
FCN1 (Ficolin 1) is a Protein Coding gene. Diseases associated with FCN1 include Progressive Relapsing Multiple Sclerosis and Mannose-Binding Lectin Deficiency. Among its related pathways are Creation of C4 and C2 activators and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and antigen binding. An important paralog of this gene is FCN2.
UniProtKB/Swiss-Prot for FCN1 Gene
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.