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FCN1 Gene

protein-coding   GIFtS: 61
GCID: GC09M137801

Ficolin (Collagen/Fibrinogen Domain Containing) 1

(Previous name: ficolin (collagen/fibrinogen domain-containing) 1)
  See FCN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ficolin (Collagen/Fibrinogen Domain Containing) 11 2     ficolin-12
Ficolin (Collagen/Fibrinogen Domain-Containing) 11 2     ficolin-A2
Collagen/Fibrinogen Domain-Containing Protein 12 3     ficolin-alpha2
FCNM2 3     Ficolin-A3
M-ficolin2 3     Ficolin-alpha3

External Ids:    HGNC: 36231   Entrez Gene: 22192   Ensembl: ENSG000000852657   OMIM: 6012525   UniProtKB: O006023   

Export aliases for FCN1 gene to outside databases

Previous GC identifers: GC09M128951 GC09M129570 GC09M131324 GC09M133240 GC09M135027 GC09M136940 GC09M107265


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCN1 Gene:
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment,
followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the
fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type
lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are
functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes,
and has been postulated to function as a plasma protein with elastin-binding activity. (provided by RefSeq, Jul
2008)

GeneCards Summary for FCN1 Gene:
FCN1 (ficolin (collagen/fibrinogen domain containing) 1) is a protein-coding gene. Diseases associated with FCN1 include mannose-binding lectin deficiency. GO annotations related to this gene include antigen binding and calcium ion binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602
Function: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to
9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3
linkage

Gene Wiki entry for FCN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCN1 gene promoter:
         TBP   STAT5B   RP58   RREB-1   FOXD3   POU6F1 (c2)   POU2F1   POU2F1a   HSF2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCN1 promoter sequence
   Search Chromatin IP Primers for FCN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

FCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCN1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M137801:  view genomic region     (about GC identifiers)

Start:
137,801,431 bp from pter      End:
137,809,809 bp from pter
Size:
8,379 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602 (See protein sequence)
Recommended Name: Ficolin-1 precursor  
Size: 326 amino acids; 35078 Da
Subunit: Homotrimer. Interacts with elastin
Sequence caution: Sequence=BAA12120.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for FCN1 (see all 7):
2D39 (3D)        2JHH (3D)        2JHI (3D)        2JHK (3D)        2JHL (3D)        2JHM (3D)    
Secondary accessions: Q5VYV5 Q92596

Explore the universe of human proteins at neXtProt for FCN1: NX_O00602

Explore proteomics data for FCN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn305
  • Modification sites at PhosphoSitePlus

  • See FCN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001994.2  
    ENSEMBL proteins: 
     ENSP00000360871  
    Reactome Protein details: O00602

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry O00602

    ProtoNet protein and cluster: O00602

    3 Blocks protein domains:
    IPB002181 Fibrinogen
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602
    Domain: The Fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the
    cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and
    looses its carbohydrate-binding ability
    Similarity: Belongs to the ficolin lectin family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 fibrinogen C-terminal domain


    Find genes that share domains with FCN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCN1_HUMAN, O00602
    Function: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to
    9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3
    linkage

         Genatlas biochemistry entry for FCN1:
    ficolin 1,TGFB1 binding protein,expressed in peripheral leukocytes and lung

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS8576206
    GO:0005509calcium ion binding TAS8576206
    GO:0005515protein binding IPI17581635
    GO:0030246carbohydrate binding TAS8576206
         
    Find genes that share ontologies with FCN1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fcna):
     immune system  mortality/aging 

    Find genes that share phenotypes with FCN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fcnatm1Tefu for FCN1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCN1_HUMAN, O00602: Secreted. Note=Found on the monocyte and granulocyte surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--

    Find genes that share ontologies with FCN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Ficolins bind to repetitive carbohydrate structures on the target cell surface0.00
    Initial triggering of complement0.85
    Lectin pathway of complement activation0.00
    Complement cascade0.68


    Find genes that share SuperPaths with FCN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for FCN1
        Ficolins bind to repetitive carbohydrate structures on the target cell surface
    Lectin pathway of complement activation
    Initial triggering of complement


        Pathway & Disease-focused RT2 Profiler PCR Array including FCN1: 
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FCN1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for FCN1 (O006021, 2, 3 ENSP000003608714) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELNP155023, ENSP000002520344I2D: score=3 STRING: ENSP00000252034
    TGFB1P011373, ENSP000002219304I2D: score=3 STRING: ENSP00000221930
    ATG5Q9H1Y03I2D: score=1 
    MASP1P487403I2D: score=1 
    MASP2O001873I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001867complement activation, lectin pathway TAS--
    GO:0006956complement activation TAS--
    GO:0008228opsonization TAS8576206
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with FCN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCN1

    3 Novoseek inferred chemical compound relationships for FCN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglucosamine 71.5 2 18826375 (1), 19294702 (1)
    serine 52.8 7 20053996 (1), 19015737 (1), 16116205 (1)
    fibrinogen 22.1 1 20032467 (1)



    Find genes that share compounds with FCN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCN1 gene: 
    NM_002003.3  

    Unigene Cluster for FCN1:

    Ficolin (collagen/fibrinogen domain containing) 1
    Hs.440898  [show with all ESTs]
    Unigene Representative Sequence: CR749452
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371806(uc004cfi.3)
    miRNA
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    Additional mRNA sequence: 

    AK314867.1 BC020635.1 CR749452.1 D83920.1 

    7 DOTS entries:

    DT.310006  DT.100750082  DT.121207883  DT.101970600  DT.91819193  DT.100737210  DT.99946928 

    Selected AceView cDNA sequences (see all 131):

    AL597481 BM708133 CR615246 AI690204 AA496792 BI030857 AI823478 BQ334624 
    CA426283 BX644677 NM_002003 BQ184033 AL583593 BM974389 BI036760 CR749452 
    AI090205 AW449291 BV183652 BM923059 BI907191 AL543456 AI671619 BX644638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACAACCT
    FCN1 Expression
    About this image


    FCN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Spleen (Hematopoietic System)
    FCN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440898

    UniProtKB/Swiss-Prot: FCN1_HUMAN, O00602
    Tissue specificity: Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and
    thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on
    lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including FCN1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FCN1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcna5
    Fcnb1
    ficolin A5
    ficolin B1
    76.82(n)1
    75(a)1
      2 (17.58 cM)5
    141341  NM_010190.11  NP_034320.11 
     256246665 
    chicken
    (Gallus gallus)
    Aves FCN21 ficolin (collagen/fibrinogen domain containing lectin) more 64.04(n)
    60.57(a)
      417298  XM_004945743.1  XP_004945800.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    many ↔ many
    1(77119042-77127931)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ734819.12   -- 74.93(n)    BQ734819.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG302803
    CG55501
    CG55501 42(a)
    (best of 7)3
    52.82(n)1
    43.72(a)1
      368831  NM_137316.31  NP_611160.21 


    ENSEMBL Gene Tree for FCN1 (if available)
    TreeFam Gene Tree for FCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCN1 gene
    FGL22  ANGPT42  FGG2  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  
    ANGPT12  ANGPTL12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    Selected SIMAP similar genes for FCN1 using alignment to 2 protein entries:     FCN1_HUMAN (see all proteins) (see all similar genes):
    DKFZp781B1032    FCN2    ANGPTL7    ANGPT1    ANGPTL2    FCN3
    ANGPT4    LFIRE1    FGL1    TNR    TNXB    TNC
    TNC variant protein    ANGPT2    TNN    FGG    MFAP4    DKFZp779N0926

    Find genes that share paralogs with FCN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCN1 (see all 423)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363414
    A colorectal cancer sample4--see VAR_0363412 Y C mis40--------
    rs1858645351,2
    --137800936(+) GGTCCA/GCGGTC 1 -- ds50010--------
    rs785492591,2
    C,F--137801014(+) CAGGCG/ACTCAC 1 -- ds50012Minor allele frequency- A:0.03WA EU 527
    rs1381842841,2
    --137801122(+) CCCCCC/TTTTTA 1 -- ds50010--------
    rs2014468061,2
    C--137801215(+) TTGGGG/TTGGAG 1 -- ds50011Minor allele frequency- T:0.00EU 303
    rs608684781,2
    C--137801283(+) AACCTC/TCCTGA 1 -- ds50013Minor allele frequency- T:0.28CSA WA 120
    rs29897341,2
    C,F,O,A,H--137801314(+) TAAATG/AAGGGT 1 -- ds5001 ese330Minor allele frequency- A:0.31NA NS EA WA CSA 2757
    rs29897351,2
    C,F,A,H--137801416(+) ACACAC/TTGAAA 1 -- ds500124Minor allele frequency- T:0.45NS EA NA WA CSA EU 2921
    rs2011328461,2
    F--137801512(+) CTGAGC/TTGGGG 1 -- ut311Minor allele frequency- T:0.01EU 419
    rs1897885771,2
    --137801538(+) TGGGCA/GTCATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FCN1 (137801431 - 137809809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FCN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv894199CNV Loss21882294
    nsv825155CNV Loss20364138
    nsv831753CNV Loss17160897
    nsv894195CNV Gain21882294
    nsv894203CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601252    OMIM disorders: --

    1 disease for FCN1:    
    About MalaCards
    mannose-binding lectin deficiency


    Find genes that share disorders with FCN1           About GenesLikeMe

    Genetic Association Database (GAD): FCN1
    Human Genome Epidemiology (HuGE) Navigator: FCN1 (2 documents)

    Export disorders for FCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCN1 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with FCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. (PubMed id 8573080)1, 2, 3 Lu J.... Reid K.B. (Biochem. J. 1996)
    2. Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. (PubMed id 20032467)1, 2, 9 Gout E....Thielens N.M. (J. Biol. Chem. 2010)
    3. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PubMed id 18032536)1, 4, 9 Vander Cruyssen B....De Keyser F. (Rheumatology (Oxford) 2007)
    4. Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. (PubMed id 8947836)1, 2, 9 Harumiya S.... Ichijo H. (J. Biochem. 1996)
    5. Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. (PubMed id 17148457)1, 2, 9 Tanio M.... Kohno T. (J. Biol. Chem. 2007)
    6. Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain. (PubMed id 20400674)1, 2 Honore C....Garred P. (J. Leukoc. Biol. 2010)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Cloning and characterization of the human lectin P35 gene and its related gene. (PubMed id 8884275)1, 3 Endo Y.... Fujita T. (Genomics 1996)
    10. Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP. (PubMed id 19741154)1, 9 RA...Borregaard N. (J. Leukoc. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2219 HGNC: 3623 AceView: FCN1 Ensembl:ENSG00000085265 euGenes: HUgn2219
    ECgene: FCN1 H-InvDB: FCN1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FCN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCN1 gene:
    Search GeneIP for patents involving FCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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