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Aliases for FCMR Gene

Aliases for FCMR Gene

  • Fc Fragment Of IgM Receptor 2 3 5
  • Regulator Of Fas-Induced Apoptosis Toso 3 4
  • IgM Fc Fragment Receptor 3 4
  • FAIM3 3 4
  • TOSO 3 4
  • Fas Apoptotic Inhibitory Molecule 3 2
  • Immunoglobulin Mu Fc Receptor 3
  • IgM Fc Receptor 3
  • Fc Mu Receptor 3

External Ids for FCMR Gene

Previous HGNC Symbols for FCMR Gene

  • FAIM3

Summaries for FCMR Gene

Entrez Gene Summary for FCMR Gene

  • Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

GeneCards Summary for FCMR Gene

FCMR (Fc Fragment Of IgM Receptor) is a Protein Coding gene. Diseases associated with FCMR include chronic lymphocytic leukemia. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot for FCMR Gene

  • May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCMR Gene

Genomics for FCMR Gene

Regulatory Elements for FCMR Gene

Promoters for FCMR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FCMR on UCSC Golden Path with GeneCards custom track

Genomic Location for FCMR Gene

Chromosome:
1
Start:
206,903,285 bp from pter
End:
206,923,247 bp from pter
Size:
19,963 bases
Orientation:
Minus strand

Genomic View for FCMR Gene

Genes around FCMR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCMR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCMR Gene

Proteins for FCMR Gene

  • Protein details for FCMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60667-FAIM3_HUMAN
    Recommended name:
    Fas apoptotic inhibitory molecule 3
    Protein Accession:
    O60667
    Secondary Accessions:
    • A8K7J2
    • B7Z6Z0
    • D9MWM3

    Protein attributes for FCMR Gene

    Size:
    390 amino acids
    Molecular mass:
    43146 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Toso is a Japanese liquor drunk on New Years day to celebrate long life and eternal youth.

    Alternative splice isoforms for FCMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCMR Gene

Proteomics data for FCMR Gene at MOPED

Post-translational modifications for FCMR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FCMR Gene

Domains & Families for FCMR Gene

Gene Families for FCMR Gene

Protein Domains for FCMR Gene

Graphical View of Domain Structure for InterPro Entry

O60667

UniProtKB/Swiss-Prot:

FAIM3_HUMAN :
  • The Ig-like domain is required for the anti-apoptotic ability.
Domain:
  • The Ig-like domain is required for the anti-apoptotic ability.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with FCMR: view

Function for FCMR Gene

Molecular function for FCMR Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
UniProtKB/Swiss-Prot Induction:
By T-cell activation.
genes like me logo Genes that share phenotypes with FCMR: view

Animal Models for FCMR Gene

MGI Knock Outs for FCMR:

Animal Model Products

  • Taconic Biosciences Mouse Models for FCMR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCMR Gene

Localization for FCMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCMR Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 3: Secreted. Note=Detected in the serum. {ECO:0000269 PubMed:21908424}.

Gene Ontology (GO) - Cellular Components for FCMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCMR: view

No data available for Subcellular locations from COMPARTMENTS for FCMR Gene

Pathways & Interactions for FCMR Gene

SuperPathways for FCMR Gene

No Data Available

Interacting Proteins for FCMR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356058%0d%0a9606.ENSP00000249499%0d%0a9606.ENSP00000306163%0d%0a
Selected Interacting proteins: O60667-FAIM3_HUMAN ENSP00000356058 for FCMR Gene via I2D STRING

Gene Ontology (GO) - Biological Process for FCMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process TAS 9586636
genes like me logo Genes that share ontologies with FCMR: view

No data available for Pathways by source and SIGNOR curated interactions for FCMR Gene

Drugs & Compounds for FCMR Gene

No Compound Related Data Available

Transcripts for FCMR Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FCMR Gene

No ASD Table

Relevant External Links for FCMR Gene

GeneLoc Exon Structure for
FCMR
ECgene alternative splicing isoforms for
FCMR

Expression for FCMR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for FCMR Gene

O60667-FAIM3_HUMAN
Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.
genes like me logo Genes that share expression patterns with FCMR: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FCMR Gene

Orthologs for FCMR Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCMR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAIM3 35
  • 77.92 (n)
  • 67.01 (a)
FAIM3 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAIM3 35
  • 79.67 (n)
  • 67.96 (a)
FAIM3 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faim3 35
  • 72.95 (n)
  • 60.72 (a)
Fcmr 16
Faim3 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAIM3 35
  • 99.4 (n)
  • 99.74 (a)
FAIM3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faim3 35
  • 72.38 (n)
  • 59.22 (a)
oppossum
(Monodelphis domestica)
Mammalia FAIM3 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAIM3 36
  • 46 (a)
OneToOne
Species with no ortholog for FCMR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCMR Gene

ENSEMBL:
Gene Tree for FCMR (if available)
TreeFam:
Gene Tree for FCMR (if available)

Paralogs for FCMR Gene

Paralogs for FCMR Gene

genes like me logo Genes that share paralogs with FCMR: view

Variants for FCMR Gene

Sequence variations from dbSNP and Humsavar for FCMR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs94872 -- 206,913,500(-) GGAGT(A/G)GAGGC intron-variant
rs182364 -- 206,923,523(+) CACAG(C/G)TGGGC upstream-variant-2KB
rs188334 -- 206,906,270(-) GGAAA(C/T)TTTAT intron-variant
rs189752 -- 206,906,437(-) CTTTT(C/T)TCAAA intron-variant
rs167082 -- 206,914,090(-) GTATC(A/G/T)GGGGC intron-variant, nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime

Variation tolerance for FCMR Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCMR Gene

HapMap Linkage Disequilibrium report
FCMR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FCMR Gene

Disorders for FCMR Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCMR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search FCMR in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCMR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCMR
genes like me logo Genes that share disorders with FCMR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCMR Gene

Publications for FCMR Gene

  1. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. (PMID: 9586636) Hitoshi Y. … Nolan G.P. (Immunity 1998) 2 3 4 67
  2. Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR. (PMID: 25888699) Kubagawa H. … Coligan J.E. (J. Immunol. 2015) 2 3
  3. Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers. (PMID: 1563211) Rainsford K.D. … Hantsbarger G. (Clin. Pharmacol. Ther. 1992) 2 3
  4. Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. (PMID: 21264533) Hancer V.S. … Aktan M. (Med. Oncol. 2012) 3
  5. Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. (PMID: 22675200) Murakami Y. … Coligan J.E. (J. Immunol. 2012) 3

Products for FCMR Gene

Sources for FCMR Gene

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