Aliases for FCMR Gene
Aliases for FCMR Gene
External Ids for FCMR Gene
- HGNC: 14315
- Entrez Gene: 9214
- Ensembl: ENSG00000162894
- OMIM: 606015
- UniProtKB: O60667
Previous HGNC Symbols for FCMR Gene
- FAIM3
Summaries for FCMR Gene
-
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
GeneCards Summary for FCMR Gene
FCMR (Fc Fragment Of IgM Receptor) is a Protein Coding gene. Diseases associated with FCMR include Chronic Lymphocytic Leukemia. An important paralog of this gene is PIGR.
UniProtKB/Swiss-Prot for FCMR Gene
-
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCMR Gene
Genomics for FCMR Gene
Regulatory Elements for FCMR Gene
Enhancers for FCMR Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCMR on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FCMR Gene
- Chromosome:
- 1
- Start:
- 206,903,285 bp from pter
- End:
- 206,923,247 bp from pter
- Size:
- 19,963 bases
- Orientation:
- Minus strand
Genomic View for FCMR Gene
Genes around FCMR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by Ensembl
- 1q32.1 by Entrez Gene
- 1q32.1 by HGNC
FCMR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCMR Gene
Proteins for FCMR Gene
-
Protein details for FCMR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60667-FAIM3_HUMAN
- Recommended name:
- Fas apoptotic inhibitory molecule 3
- Protein Accession:
- O60667
- A8K7J2
- B7Z6Z0
- D9MWM3
Protein attributes for FCMR Gene
- Size:
- 390 amino acids
- Molecular mass:
- 43146 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Toso is a Japanese liquor drunk on New Years day to celebrate long life and eternal youth.
Post-translational modifications for FCMR Gene
Other Protein References for FCMR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FCMR
-
Custom Antibody ServicesOriGene Antibodies for FCMR
- Novus Biologicals Antibodies for FCMR
- Invitrogen Antibodies for FCMR
- Invitrogen Antibodies for FCMR
- antibodies-online Antibodies for FCMR: See all 65
- GeneTex FCMR antibody for FCMR
-
Custom Antibody ServicesProSci Antibodies for FCMR
-
Santa Cruz Biotechnology (SCBT) Antibodies for FCMR
Protein Products
-
OriGene Purified Proteins for FCMR
- Search Origene for MassSpec and Protein Over-expression Lysates for FCMR
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- Sino Biological Recombinant Proteins for FCMR
- antibodies-online Proteins for FCMR: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FCMR
Assay Products
- antibodies-online Kits for FCMR: See all 10
No data available for DME Specific Peptides for FCMR Gene
Domains & Families for FCMR Gene
Gene Families for FCMR Gene
Protein Domains for FCMR Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCMR Gene
Graphical View of Domain Structure for InterPro Entry
O60667- Domain:
-
- The Ig-like domain is required for the anti-apoptotic ability.
Function for FCMR Gene
Molecular function for FCMR Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
- UniProtKB/Swiss-Prot Induction:
- By T-cell activation.
Phenotypes for FCMR Gene
- MGI mutant phenotypes for FCMR:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for FCMR:
-
- Mitotic spindle defects
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased G1 DNA content
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for FCMR Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for FCMR
-
ViGene Biosciences lentiviral particle packaged cDNA for FCMR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCMR gene
- Search ViGene Biosciences for FCMR
CRISPR Products
-
OriGene CRISPR knockouts for FCMR
- GenScript: Design CRISPR guide RNA sequences for FCMR
miRNA for FCMR Gene
- miRTarBase miRNAs that target FCMR
miRNA Products
- Search ViGene Biosciences for FCMR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCMR
- Browse OriGene Inhibitory RNA Products For FCMR
-
ViGene Biosciences ready-to-package AAV shRNAs for FCMR gene
Clone Products
- Sino Biological Human cDNA Clone for FCMR
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- R&D Systems cDNA Clones for FCMR (Fc mu R/FAIM3)
Cell Line Products
-
Horizon Cell Lines for FCMR
-
ViGene Biosciences adenoviral particle packaged cDNA for FCMR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCMR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCMR gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCMR Gene
Localization for FCMR Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCMR Gene
- Isoform 1: Membrane; Single-pass membrane protein.
- Isoform 3: Secreted. Note=Detected in the serum. {ECO:0000269 PubMed:21908424}.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 3 |
| cytosol | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for FCMR Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006968 | cellular defense response | TAS | 9586636 |
| GO:0043066 | negative regulation of apoptotic process | TAS | 9586636 |
No data available for Pathways by source and SIGNOR curated interactions for FCMR Gene
Transcripts for FCMR Gene
mRNA/cDNA for FCMR Gene
- (6) REFSEQ mRNAs :
- (154) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FCMR
- GenScript: Design CRISPR guide RNA sequences for FCMR
miRNA Products
- Search ViGene Biosciences for FCMR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCMR
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-
ViGene Biosciences ready-to-package AAV shRNAs for FCMR gene
Clone Products
- Sino Biological Human cDNA Clone for FCMR
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Flow Cytometry Products
Expression for FCMR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Adipose (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
NURSA nuclear receptor signaling pathways regulating expression of FCMR Gene:
FCMRmRNA Expression by UniProt/SwissProt for FCMR Gene:
O60667-FAIM3_HUMAN
Tissue specificity:
Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.
Evidence on tissue expression from TISSUES for FCMR Gene
- Spleen(4.8)
- Blood(3.3)
- Intestine(2.5)
- Lymph node(2.5)
Primer Products
-
OriGene qPCR primer pairs for FCMR
-
OriGene qPCR primer pairs and template standards for FCMR
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCMR Gene
Orthologs for FCMR Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAIM3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FAIM3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAIM3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Faim3 34 35 |
|
||
| Fcmr 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Faim3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAIM3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FAIM3 35 |
|
OneToOne |
- Species where no ortholog for FCMR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCMR Gene
Variants for FCMR Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000038588 | -- | 206,905,112(+) | GTCTT(C/T)AGAGA | nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime | |
| rs1000277069 | -- | 206,917,794(+) | CGAAT(-/G)TTTTT | intron-variant | |
| rs1000337753 | -- | 206,904,843(+) | AGACG(A/T)CCTGG | nc-transcript-variant, utr-variant-3-prime | |
| rs1000594936 | -- | 206,917,337(+) | ATCAA(A/T)CGGGG | intron-variant | |
| rs1000615249 | -- | 206,910,678(+) | CCTTC(C/T)GGTGT | intron-variant |
Residual Variation Intolerance Score:
67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.44;
28.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCMR Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCMR
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCMR Gene
Disorders for FCMR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic lymphocytic leukemia |
|
|
Search FCMR in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FCMR
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FCMR
No data available for UniProtKB/Swiss-Prot and Genatlas for FCMR Gene
Publications for FCMR Gene
- Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. (PMID: 9586636) Hitoshi Y. … Nolan G.P. (Immunity 1998) 2 3 4 64
- Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR. (PMID: 25888699) Kubagawa H. … Coligan J.E. (J. Immunol. 2015) 2 3 64
- Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. (PMID: 21908424) Li F.J. … Kubagawa H. (Blood 2011) 3 4 64
- Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers. (PMID: 1563211) Rainsford K.D. … Hantsbarger G. (Clin. Pharmacol. Ther. 1992) 2 3 64
- Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. (PMID: 21264533) Hancer V.S. … Aktan M. (Med. Oncol. 2012) 3 64
Products for FCMR Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for FCMR (Fc mu R/FAIM3)
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for FCMR
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- Sino Biological Antibodies
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- Novus Biologicals Antibodies for FCMR
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- Taconic Biosciences Mouse Models for FCMR
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- Invitrogen Antibodies for FCMR
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- antibodies-online Antibodies for FCMR: See all 65
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- antibodies-online Proteins for FCMR: See all 7
- Search antibodies-online for peptides
- GeneTex FCMR antibody for FCMR
- Search GeneTex for Proteins for FCMR
- ViGene Biosciences adenoviral particle packaged cDNA for FCMR gene
- ViGene Biosciences lentiviral particle packaged cDNA for FCMR gene
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- Search ViGene Biosciences for FCMR
- Santa Cruz Biotechnology (SCBT) Antibodies for FCMR
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- Search for FCMR Proteins at ProSci
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- Cyagen custom Knockout/knockin (KOKI) mouse models for FCMR
- VectorBuilder custom plasmid, inducible vectors for FCMR
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCMR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer