FCHSD2 Gene
protein-coding GIFtS: 50
GCID: GC11M072547
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FCH and double SH3 domains 2(Previous name: SH3 multiple domains 3 )
(Previous symbol: SH3MD3)
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Aliases
for FCHSD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FCH And Double SH3 Domains 21 2 | | NWK2 | | SH3MD31 2 3 | | Carom3 | | SH3 Multiple Domains 31 2 | | FCH And Double SH3 Domains Protein 22 | | KIAA07691 3 | | Nervous Wreck Homolog2 | | SH3 Multiple Domains Protein 32 3 | | Carom3 |
Export aliases for FCHSD2 gene to outside databasesPrevious GC identifers: GC11M072275 GC11M072225 GC11M068842 |
Summaries
for FCHSD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for FCHSD2
|
Genomic Views
for FCHSD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCHSD2 gene promoter:
TBP STAT1 NF-1/L NF-1 Sp1 HNF-3beta Egr-4 Gfi-1 AREB6 TFIID
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCHSD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCHSD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.3FCHSD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M072547: view genomic region
(about GC identifiers)
Start:
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72,547,790 bp from pter |
End:
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72,853,306 bp from pter |
Size:
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305,517 bases |
Orientation:
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minus strand |
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Proteins
for FCHSD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCSD2_HUMAN, O94868 (See
protein sequence)Recommended Name: FCH and double SH3 domains protein 2 Size: 740 amino acids; 84276 Da
Subunit: Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1
Sequence caution: Sequence=BAA34489.2; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for FCHSD2:2DL5 (3D)
2DL7 (3D)
Secondary accessions: B4DNI3 Q7L8J9 Q8WVM2 Q96FV7 Q9UF77Alternative splicing: 3 isoforms: O94868-1 O94868-2 O94868-3 Explore the universe of human proteins at neXtProt for FCHSD2: NX_O94868
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94868
FCHSD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055639.2
ENSEMBL proteins: ENSP00000308978 ENSP00000386987 ENSP00000386722 ENSP00000386903 ENSP00000402972 ENSP00000386314 ENSP00000406420 ENSP00000441616 ENSP00000408706
Human Recombinant Protein Products:
FCHSD2 Antibody Products:
Assay Products for FCHSD2: |
Protein
Domains /
Families
for FCHSD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCHSD2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94868ProtoNet protein and cluster: O94868 1 Blocks protein family: IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: FCSD2_HUMAN, O94868Similarity: Contains 1 FCH domainSimilarity: Contains 2 SH3 domains |
Function
for FCHSD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCHSD2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCHSD2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHSD2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FCHSD2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FCHSD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCHSD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/30 Interacting proteins for FCHSD2 (O948681, 2, 3 ENSP000003867224) via UniProtKB, MINT, STRING, and/or I2D (see all 30)About this table
|
Drugs & Compounds
for FCHSD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FCHSD2
Search CenterWatch for drugs/clinical trials and news about FCHSD2 / FCSD2
|
Transcripts
for FCHSD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCHSD2 gene: NM_014824.2 Unigene Cluster for FCHSD2: FCH and double SH3 domains 2 Hs.577053 [show with all ESTs]Unigene Representative Sequence: NM_01482410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311172(uc001oth.4) ENST00000409314(uc009ytl.3 uc010rrg.2)
ENST00000409418 ENST00000474099 ENST00000409263 ENST00000458644 ENST00000409853(uc001oti.2)
ENST00000432043 ENST00000543644 ENST00000422375
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCHSD2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCHSD2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FCHSD2 (NM_014824) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCHSD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHSD2 |
Additional cDNA sequence: AB018312.1 AK128381.1 AK296376.1 AK297928.1 AL080236.1 AL133567.1 BC010394.1 BC017751.1 14 DOTS entries: DT.97781938 DT.314665 DT.100026669 DT.95271420 DT.100780260 DT.95220639 DT.95271418 DT.120697616 DT.91818929 DT.91991910 DT.92465938 DT.120697444 DT.92465924 DT.92465971 24/167 AceView cDNA sequences (see all 167): AI655690 AI825771 AL046367 BQ720875 BE463795 AI623254 AI672421 BG541971 Z45480 AW025979 Z44181 BG388528 BC017751 CD722824 BU161639 BU621921 AI866699 AI201270 AI243845 BQ181350 AW504155 AA768713 BX643249 BQ021044
GeneLoc Exon Structure
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Expression
for FCHSD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCHSD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCCTTTTT
About this image
See FCHSD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCHSD2
SOURCE GeneReport for Unigene cluster: Hs.577053
UniProtKB/Swiss-Prot: FCSD2_HUMAN, O94868Tissue specificity: Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney
SABiosciences Custom PCR Arrays for FCHSD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCHSD2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHSD2 |
Orthologs
for FCHSD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FCHSD2 gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FCHSD21 |
FCH and double SH3 domains 2 |
80.63(n)
88.4(a) |
|
419068 XM_417258.3 XP_417258.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FCHSD26 |
-- |
87(a) |
1 ↔ 1 |
GL343298.1(595393-679417) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX688645.12 |
-- |
73.29(n) |
|
BX688645.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BI881946.12 |
-- |
74.15(n) |
|
BI881946.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nwk1 |
nervous wreck |
46.71(n)
36.73(a) |
|
39052 NM_140033.2 NP_648290.2 |
ENSEMBL Gene Tree for FCHSD2 (if available)
TreeFam Gene Tree for FCHSD2 (if available) |
Paralogs
for FCHSD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCHSD2 gene
- FCHSD12
4 SIMAP similar genes for FCHSD2 using alignment to 7 protein entries: FCSD2_HUMAN (see all proteins):ARHGEF7 FCHSD1 SH3GL1 SH3GL2
FCHSD2 for paralogs About GeneDecksing
|
Genomic Variants
for FCHSD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCHSD2 (72547790 - 72797790 bp, first 250kb of FCHSD2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FCHSD2
1 CNV: 5276 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCHSD2 |
|
Disorders
/ Diseases
for FCHSD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCHSD2 for disorders About GeneDecksing
4  diseases for FCHSD2: About MalaCardsgenital herpes pulmonary edema pancreatic cancer pancreatitis
Human Genome Epidemiology (HuGE) Navigator: FCHSD2 (1 document)
Export disorders for FCHSD2 gene to outside databases
|
Publications
for FCHSD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCHSD2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with FCHSD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. (PubMed id 15067381)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. (PubMed id 14627983)1, 2 Ohno H.... Hata Y. (2003)
- FCHSD2 predicts response to chemotherapy in acute myel oid leukemia patients. (PubMed id 22902056)1 Han Y....Minden M.D. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for FCHSD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCHSD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCHSD2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FCHSD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCHSD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCHSD2 gene:
Search GeneIP for patents involving FCHSD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCHSD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCHSD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCHSD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCHSD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCHSD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCHSD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCHSD2 |
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 | | | FCHSD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHSD2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHSD2 |
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