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Aliases for FCHSD2 Gene

Aliases for FCHSD2 Gene

  • FCH And Double SH3 Domains 2 2 3
  • SH3 Multiple Domains Protein 3 3 4
  • SH3 Multiple Domains 3 2 3
  • SH3MD3 3 4
  • Carom 3 4
  • F-BAR And Double SH3 Domains Protein 2 3
  • FCH And Double SH3 Domains Protein 2 3
  • Nervous Wreck Homolog 3
  • KIAA0769 4
  • NWK 3

External Ids for FCHSD2 Gene

Previous HGNC Symbols for FCHSD2 Gene

  • SH3MD3

Previous GeneCards Identifiers for FCHSD2 Gene

  • GC11M072275
  • GC11M072225
  • GC11M072547
  • GC11M068842

Summaries for FCHSD2 Gene

GeneCards Summary for FCHSD2 Gene

FCHSD2 (FCH And Double SH3 Domains 2) is a Protein Coding gene. An important paralog of this gene is FCHSD1.

Gene Wiki entry for FCHSD2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCHSD2 Gene

Genomics for FCHSD2 Gene

Regulatory Elements for FCHSD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FCHSD2 Gene

72,836,745 bp from pter
73,142,261 bp from pter
305,517 bases
Minus strand

Genomic View for FCHSD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCHSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCHSD2 Gene

Proteins for FCHSD2 Gene

  • Protein details for FCHSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-BAR and double SH3 domains protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DNI3
    • Q7L8J9
    • Q8WVM2
    • Q96FV7
    • Q9UF77

    Protein attributes for FCHSD2 Gene

    740 amino acids
    Molecular mass:
    84276 Da
    Quaternary structure:
    • Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1.
    • Sequence=BAA34489.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCHSD2 Gene

    Alternative splice isoforms for FCHSD2 Gene


neXtProt entry for FCHSD2 Gene

Proteomics data for FCHSD2 Gene at MOPED

Post-translational modifications for FCHSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FCHSD2 Gene

Domains for FCHSD2 Gene

Protein Domains for FCHSD2 Gene


Suggested Antigen Peptide Sequences for FCHSD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O94868
  • Contains 1 F-BAR domain.
  • Contains 2 SH3 domains.
genes like me logo Genes that share domains with FCHSD2: view

No data available for Gene Families for FCHSD2 Gene

Function for FCHSD2 Gene

Gene Ontology (GO) - Molecular Function for FCHSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14627983
genes like me logo Genes that share ontologies with FCHSD2: view

Animal Model Products

miRNA for FCHSD2 Gene

miRTarBase miRNAs that target FCHSD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCHSD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FCHSD2 Gene

Localization for FCHSD2 Gene

Subcellular locations from

Jensen Localization Image for FCHSD2 Gene COMPARTMENTS Subcellular localization image for FCHSD2 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FCHSD2 Gene

Pathways for FCHSD2 Gene

SuperPathways for FCHSD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCHSD2 Gene


No data available for Pathways by source for FCHSD2 Gene

Transcripts for FCHSD2 Gene

Unigene Clusters for FCHSD2 Gene

FCH and double SH3 domains 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCHSD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCHSD2 Gene

No ASD Table

Relevant External Links for FCHSD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCHSD2 Gene

mRNA expression in normal human tissues for FCHSD2 Gene

Protein differential expression in normal tissues for FCHSD2 Gene

This gene is overexpressed in Lymph node (24.4), Blymphocyte (22.5), and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FCHSD2 Gene

SOURCE GeneReport for Unigene cluster for FCHSD2 Gene Hs.744959

mRNA Expression by UniProt/SwissProt for FCHSD2 Gene

Tissue specificity: Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.
genes like me logo Genes that share expressions with FCHSD2: view

Expression partners for FCHSD2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FCHSD2 Gene

Orthologs for FCHSD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCHSD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FCHSD2 35
  • 94.28 (n)
  • 97.03 (a)
  • 97 (a)
(Canis familiaris)
Mammalia FCHSD2 35
  • 94.55 (n)
  • 97.03 (a)
  • 97 (a)
(Mus musculus)
Mammalia Fchsd2 35
  • 91.8 (n)
  • 96.49 (a)
Fchsd2 16
Fchsd2 36
  • 93 (a)
(Pan troglodytes)
Mammalia FCHSD2 35
  • 99.23 (n)
  • 99.32 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Fchsd2 35
  • 91.26 (n)
  • 96.03 (a)
(Monodelphis domestica)
Mammalia FCHSD2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FCHSD2 36
  • 91 (a)
(Gallus gallus)
Aves FCHSD2 35
  • 80.48 (n)
  • 88.18 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia FCHSD2 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fchsd2 35
  • 74.41 (n)
  • 83.31 (a)
(Danio rerio)
Actinopterygii LOC100536596 35
  • 64.41 (n)
  • 61.1 (a)
CABZ01070631.1 36
  • 74 (a)
CU570791.5 36
  • 61 (a)
FCHSD2 (3 of 5) 36
  • 71 (a)
FCHSD2 (4 of 5) 36
  • 73 (a)
FCHSD2 (5 of 5) 36
  • 55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006774 35
  • 47.49 (n)
  • 40.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta nwk 35
  • 49.24 (n)
  • 41.46 (a)
nwk 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10491 36
  • 38 (a)
Species with no ortholog for FCHSD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FCHSD2 Gene

Gene Tree for FCHSD2 (if available)
Gene Tree for FCHSD2 (if available)

Paralogs for FCHSD2 Gene

Paralogs for FCHSD2 Gene

Selected SIMAP similar genes for FCHSD2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FCHSD2: view

Variants for FCHSD2 Gene

Sequence variations from dbSNP and Humsavar for FCHSD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1620 -- 73,009,815(+) ttctt(A/G)ctgtt intron-variant
rs152997 -- 72,909,380(-) gtagc(A/C/G/T)agccg intron-variant
rs429574 -- 72,909,351(+) GCCCA(A/G/T)GCTGG intron-variant
rs479093 -- 72,974,529(+) ttcaa(C/T)agagt intron-variant
rs493315 -- 72,970,906(+) CAAGA(A/G)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCHSD2 Gene

Variant ID Type Subtype PubMed ID
esv2422418 CNV Duplication 17116639
nsv386 CNV Loss 18451855

Relevant External Links for FCHSD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCHSD2 Gene

Disorders for FCHSD2 Gene

Relevant External Links for FCHSD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FCHSD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FCHSD2 Gene

Publications for FCHSD2 Gene

  1. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. (PMID: 15067381) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. (PMID: 14627983) Ohno H. … Hata Y. (Oncogene 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for FCHSD2 Gene

Sources for FCHSD2 Gene

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