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Aliases for FCHSD1 Gene

Aliases for FCHSD1 Gene

  • FCH And Double SH3 Domains 1 2 3
  • F-BAR And Double SH3 Domains Protein 1 3
  • FCH And Double SH3 Domains Protein 1 3
  • Nervous Wreck Homolog 2 3
  • NWK2 3

External Ids for FCHSD1 Gene

Previous GeneCards Identifiers for FCHSD1 Gene

  • GC05M141048
  • GC05M140999
  • GC05M136163
  • GC05M141018

Summaries for FCHSD1 Gene

GeneCards Summary for FCHSD1 Gene

FCHSD1 (FCH And Double SH3 Domains 1) is a Protein Coding gene. An important paralog of this gene is FCHSD2.

Gene Wiki entry for FCHSD1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCHSD1 Gene

Genomics for FCHSD1 Gene

Regulatory Elements for FCHSD1 Gene

Genomic Location for FCHSD1 Gene

Start:
141,639,302 bp from pter
End:
141,651,419 bp from pter
Size:
12,118 bases
Orientation:
Minus strand

Genomic View for FCHSD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCHSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCHSD1 Gene

Proteins for FCHSD1 Gene

  • Protein details for FCHSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WN1-FCSD1_HUMAN
    Recommended name:
    F-BAR and double SH3 domains protein 1
    Protein Accession:
    Q86WN1
    Secondary Accessions:
    • Q6UX75
    • Q86Y77
    • Q9NXX8

    Protein attributes for FCHSD1 Gene

    Size:
    690 amino acids
    Molecular mass:
    76942 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92232.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FCHSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCHSD1 Gene

Proteomics data for FCHSD1 Gene at MOPED

Post-translational modifications for FCHSD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FCHSD1 Gene

No data available for DME Specific Peptides for FCHSD1 Gene

Domains for FCHSD1 Gene

Protein Domains for FCHSD1 Gene

Suggested Antigen Peptide Sequences for FCHSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WN1

UniProtKB/Swiss-Prot:

FCSD1_HUMAN :
  • Q86WN1
Domain:
  • Contains 1 F-BAR domain.
  • Contains 2 SH3 domains.
genes like me logo Genes that share domains with FCHSD1: view

No data available for Gene Families for FCHSD1 Gene

Function for FCHSD1 Gene

Gene Ontology (GO) - Molecular Function for FCHSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FCHSD1: view

Phenotypes for FCHSD1 Gene

GenomeRNAi human phenotypes for FCHSD1:
genes like me logo Genes that share phenotypes with FCHSD1: view

Animal Model Products

CRISPR Products

miRNA for FCHSD1 Gene

miRTarBase miRNAs that target FCHSD1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCHSD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FCHSD1 Gene

Localization for FCHSD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCHSD1 Gene COMPARTMENTS Subcellular localization image for FCHSD1 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FCHSD1 Gene

Pathways for FCHSD1 Gene

SuperPathways for FCHSD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCHSD1 Gene

None

No data available for Pathways by source for FCHSD1 Gene

Transcripts for FCHSD1 Gene

Unigene Clusters for FCHSD1 Gene

FCH and double SH3 domains 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCHSD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FCHSD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCHSD1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5: - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:

Relevant External Links for FCHSD1 Gene

GeneLoc Exon Structure for
FCHSD1
ECgene alternative splicing isoforms for
FCHSD1

Expression for FCHSD1 Gene

mRNA expression in normal human tissues for FCHSD1 Gene

mRNA differential expression in normal tissues according to GTEx for FCHSD1 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FCHSD1 Gene

SOURCE GeneReport for Unigene cluster for FCHSD1 Gene Hs.591257

genes like me logo Genes that share expressions with FCHSD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FCHSD1 Gene

Orthologs for FCHSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCHSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCHSD1 35
  • 98.29 (n)
  • 97.95 (a)
FCHSD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCHSD1 35
  • 90.72 (n)
  • 93.19 (a)
dog
(Canis familiaris)
Mammalia FCHSD1 35
  • 89.23 (n)
  • 91.16 (a)
FCHSD1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fchsd1 35
  • 88.13 (n)
  • 91.28 (a)
Fchsd1 16
Fchsd1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCHSD1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fchsd1 35
  • 87.63 (n)
  • 90.72 (a)
chicken
(Gallus gallus)
Aves FCHSD1 35
  • 61.44 (n)
  • 50.62 (a)
FCHSD1 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FCHSD1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fchsd1 35
  • 58.16 (n)
  • 52.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta nwk 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10491 36
  • 33 (a)
OneToMany
Species with no ortholog for FCHSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCHSD1 Gene

ENSEMBL:
Gene Tree for FCHSD1 (if available)
TreeFam:
Gene Tree for FCHSD1 (if available)

Paralogs for FCHSD1 Gene

Paralogs for FCHSD1 Gene

Selected SIMAP similar genes for FCHSD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FCHSD1: view

Variants for FCHSD1 Gene

Sequence variations from dbSNP and Humsavar for FCHSD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs173683 -- 141,648,480(+) ctctg(C/G)aatgt intron-variant
rs251041 -- 141,648,321(+) cacca(C/G)gttca intron-variant
rs251177 -- 141,647,317(+) GACAA(C/T)GTGTG intron-variant
rs251180 -- 141,642,368(+) ggagt(A/G)gaggc intron-variant
rs374073 -- 141,643,863(+) aaaaa(A/G)aagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCHSD1 Gene

Variant ID Type Subtype PubMed ID
nsv5034 CNV Insertion 18451855

Relevant External Links for FCHSD1 Gene

HapMap Linkage Disequilibrium report
FCHSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCHSD1 Gene

Disorders for FCHSD1 Gene

Relevant External Links for FCHSD1

Genetic Association Database (GAD)
FCHSD1
Human Genome Epidemiology (HuGE) Navigator
FCHSD1
genes like me logo Genes that share disorders with FCHSD1: view

No data available for UniProtKB/Swiss-Prot for FCHSD1 Gene

Publications for FCHSD1 Gene

  1. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. (PMID: 15067381) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 23
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FCHSD1 Gene

Sources for FCHSD1 Gene

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