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Aliases for FCHSD1 Gene

Aliases for FCHSD1 Gene

  • FCH And Double SH3 Domains 1 2 3 5
  • F-BAR And Double SH3 Domains Protein 1 3
  • FCH And Double SH3 Domains Protein 1 3
  • Nervous Wreck Homolog 2 3
  • NWK2 3

External Ids for FCHSD1 Gene

Previous GeneCards Identifiers for FCHSD1 Gene

  • GC05M141048
  • GC05M140999
  • GC05M136163
  • GC05M141018

Summaries for FCHSD1 Gene

GeneCards Summary for FCHSD1 Gene

FCHSD1 (FCH And Double SH3 Domains 1) is a Protein Coding gene. An important paralog of this gene is FCHSD2.

Gene Wiki entry for FCHSD1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCHSD1 Gene

Genomics for FCHSD1 Gene

Regulatory Elements for FCHSD1 Gene

Enhancers for FCHSD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F142388 1.5 FANTOM5 Ensembl ENCODE 14.4 -738.9 -738911 4.3 ATF1 KLF17 FEZF1 ZNF155 ZNF366 SCRT2 CREM ZNF263 ZNF680 ZNF623 LOC102723915 HDAC3 LINC01844 FCHSD1 KIAA0141 LOC105378203 GC05M142394 GC05P142356
GH05F141597 1.7 FANTOM5 Ensembl ENCODE 12.2 +47.5 47528 13.8 PKNOX1 ARNT ARID4B SIN3A YY1 CBX5 ZNF143 ZNF263 JUNB TBX21 RELL2 HDAC3 FCHSD1 DIAPH1 LOC100505658 PCDHGA6 PCDHGB6 KIAA0141 PCDHGA8 PCDHB17P
GH05F141319 1.2 ENCODE 16.5 +330.8 330779 1.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PCDHB15 FCHSD1 MRPL11P2 VTRNA1-1 PCDHGB4 PCDHB11 PCDHB13 HDAC3 PCDHGB3 PCDHB12
GH05F140725 1.1 ENCODE 16.5 +925.4 925446 1.1 PKNOX1 ARNT ARID4B SIN3A ZNF2 FOS KLF13 DEK ZNF263 SP3 HDAC3 LOC102723915 PCDHA4 TMCO6 PCDHA3 FCHSD1 HARS LOC101929719 PCDHB19P PCDHB17P
GH05F141592 1 Ensembl ENCODE 17.6 +59.1 59128 0.6 CTCF SAP130 ARID4B RAD21 ZNF121 ZNF664 NCOR1 GATAD1 ZNF143 SMC3 FCHSD1 LOC102723915 DIAPH1 RELL2 HDAC3 PCDHGA1 GC05P141898 RPS27AP10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCHSD1 on UCSC Golden Path with GeneCards custom track

Promoters for FCHSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001292084 128 1401 TBP HDAC1 ARID4B EGR1 SCRT2 CREM EGR2 SP3 SP5 SMAD5

Genomic Location for FCHSD1 Gene

Chromosome:
5
Start:
141,639,302 bp from pter
End:
141,651,428 bp from pter
Size:
12,127 bases
Orientation:
Minus strand

Genomic View for FCHSD1 Gene

Genes around FCHSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCHSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCHSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCHSD1 Gene

Proteins for FCHSD1 Gene

  • Protein details for FCHSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WN1-FCSD1_HUMAN
    Recommended name:
    F-BAR and double SH3 domains protein 1
    Protein Accession:
    Q86WN1
    Secondary Accessions:
    • Q6UX75
    • Q86Y77
    • Q9NXX8

    Protein attributes for FCHSD1 Gene

    Size:
    690 amino acids
    Molecular mass:
    76942 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92232.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FCHSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCHSD1 Gene

Post-translational modifications for FCHSD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FCHSD1 Gene

Domains & Families for FCHSD1 Gene

Gene Families for FCHSD1 Gene

Protein Domains for FCHSD1 Gene

Suggested Antigen Peptide Sequences for FCHSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WN1

UniProtKB/Swiss-Prot:

FCSD1_HUMAN :
  • Contains 1 F-BAR domain.
Domain:
  • Contains 1 F-BAR domain.
  • Contains 2 SH3 domains.
genes like me logo Genes that share domains with FCHSD1: view

Function for FCHSD1 Gene

Phenotypes for FCHSD1 Gene

genes like me logo Genes that share phenotypes with FCHSD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FCHSD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCHSD1 Gene

Localization for FCHSD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCHSD1 gene
Compartment Confidence
nucleus 3
cytosol 3
endosome 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FCHSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031594 neuromuscular junction IBA --
GO:0055037 recycling endosome IBA --
genes like me logo Genes that share ontologies with FCHSD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FCHSD1 Gene

Pathways & Interactions for FCHSD1 Gene

SuperPathways for FCHSD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCHSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007274 neuromuscular synaptic transmission IBA --
GO:0030833 regulation of actin filament polymerization IBA --
genes like me logo Genes that share ontologies with FCHSD1: view

No data available for Pathways by source and SIGNOR curated interactions for FCHSD1 Gene

Transcripts for FCHSD1 Gene

Unigene Clusters for FCHSD1 Gene

FCH and double SH3 domains 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCHSD1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5: - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:

Relevant External Links for FCHSD1 Gene

GeneLoc Exon Structure for
FCHSD1
ECgene alternative splicing isoforms for
FCHSD1

Expression for FCHSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCHSD1 Gene

mRNA differential expression in normal tissues according to GTEx for FCHSD1 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for FCHSD1 Gene

This gene is overexpressed in Heart (45.4) and Lung (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FCHSD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FCHSD1 Gene:

FCHSD1

SOURCE GeneReport for Unigene cluster for FCHSD1 Gene:

Hs.591257
genes like me logo Genes that share expression patterns with FCHSD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FCHSD1 Gene

Orthologs for FCHSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCHSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCHSD1 34 35
  • 98.29 (n)
cow
(Bos Taurus)
Mammalia FCHSD1 34
  • 90.72 (n)
dog
(Canis familiaris)
Mammalia FCHSD1 34 35
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Fchsd1 34 16 35
  • 88.13 (n)
rat
(Rattus norvegicus)
Mammalia Fchsd1 34
  • 87.63 (n)
oppossum
(Monodelphis domestica)
Mammalia FCHSD1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves FCHSD1 34 35
  • 61.44 (n)
lizard
(Anolis carolinensis)
Reptilia FCHSD1 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fchsd1 34
  • 58.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta nwk 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10491 35
  • 33 (a)
OneToMany
Species where no ortholog for FCHSD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCHSD1 Gene

ENSEMBL:
Gene Tree for FCHSD1 (if available)
TreeFam:
Gene Tree for FCHSD1 (if available)

Paralogs for FCHSD1 Gene

Paralogs for FCHSD1 Gene

(1) SIMAP similar genes for FCHSD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FCHSD1: view

Variants for FCHSD1 Gene

Sequence variations from dbSNP and Humsavar for FCHSD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10059833 -- 141,651,987(+) GATGC(A/G)CAGGA upstream-variant-2KB
rs1048452 -- 141,641,194(-) TAGTT(C/T)TGGCC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1048453 -- 141,641,175(-) TCCCC(A/C)CCCTG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1048455 -- 141,641,157(-) GACCC(A/C)CCCCA intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1048456 -- 141,641,152(-) ACCCC(A/C)CTCTG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FCHSD1 Gene

Variant ID Type Subtype PubMed ID
nsv1154058 CNV deletion 26484159
nsv5034 CNV insertion 18451855

Variation tolerance for FCHSD1 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCHSD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCHSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCHSD1 Gene

Disorders for FCHSD1 Gene

Relevant External Links for FCHSD1

Genetic Association Database (GAD)
FCHSD1
Human Genome Epidemiology (HuGE) Navigator
FCHSD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCHSD1

No disorders were found for FCHSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCHSD1 Gene

Publications for FCHSD1 Gene

  1. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. (PMID: 15067381) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for FCHSD1 Gene

Sources for FCHSD1 Gene

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