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Aliases for FCHO2 Gene

Aliases for FCHO2 Gene

  • FCH Domain Only 2 2 3

External Ids for FCHO2 Gene

Previous GeneCards Identifiers for FCHO2 Gene

  • GC05P072287
  • GC05P067457

Summaries for FCHO2 Gene

GeneCards Summary for FCHO2 Gene

FCHO2 (FCH Domain Only 2) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding and phosphatidylserine binding. An important paralog of this gene is FCHO1.

UniProtKB/Swiss-Prot for FCHO2 Gene

  • Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.

Gene Wiki entry for FCHO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCHO2 Gene

Genomics for FCHO2 Gene

Regulatory Elements for FCHO2 Gene

Genomic Location for FCHO2 Gene

Start:
72,955,981 bp from pter
End:
73,090,522 bp from pter
Size:
134,542 bases
Orientation:
Plus strand

Genomic View for FCHO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCHO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCHO2 Gene

Proteins for FCHO2 Gene

  • Protein details for FCHO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0JRZ9-FCHO2_HUMAN
    Recommended name:
    F-BAR domain only protein 2
    Protein Accession:
    Q0JRZ9
    Secondary Accessions:
    • A8K6W7
    • B2RNQ9
    • B4DHK0
    • E9PG79
    • Q0JTJ3
    • Q96CF5

    Protein attributes for FCHO2 Gene

    Size:
    810 amino acids
    Molecular mass:
    88924 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R, ITSN1 and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex AP-2 at the plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis.
    Miscellaneous:
    • Deforms liposomes into a range of tubule diameters from 20 to 130 nm in vitro
    SequenceCaution:
    • Sequence=AAH14311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCHO2 Gene

    Alternative splice isoforms for FCHO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCHO2 Gene

Proteomics data for FCHO2 Gene at MOPED

Post-translational modifications for FCHO2 Gene

  • Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity).
  • Ubiquitination at Lys58
  • Modification sites at PhosphoSitePlus

Other Protein References for FCHO2 Gene

No data available for DME Specific Peptides for FCHO2 Gene

Domains for FCHO2 Gene

Protein Domains for FCHO2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FCHO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0JRZ9

UniProtKB/Swiss-Prot:

FCHO2_HUMAN :
  • Q0JRZ9
Domain:
  • Contains 1 F-BAR domain.
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the FCHO family.
genes like me logo Genes that share domains with FCHO2: view

No data available for Gene Families for FCHO2 Gene

Function for FCHO2 Gene

Molecular function for FCHO2 Gene

UniProtKB/Swiss-Prot Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.

Gene Ontology (GO) - Molecular Function for FCHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding ISS --
GO:0005515 protein binding IPI 19380743
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
GO:0035091 phosphatidylinositol binding ISS --
genes like me logo Genes that share ontologies with FCHO2: view

Phenotypes for FCHO2 Gene

genes like me logo Genes that share phenotypes with FCHO2: view

miRNA for FCHO2 Gene

miRTarBase miRNAs that target FCHO2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FCHO2 Gene

Localization for FCHO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCHO2 Gene

Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCHO2 Gene COMPARTMENTS Subcellular localization image for FCHO2 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FCHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005905 coated pit IDA 21762413
GO:0030136 clathrin-coated vesicle IDA 21762413
genes like me logo Genes that share ontologies with FCHO2: view

Pathways for FCHO2 Gene

SuperPathways for FCHO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010324 membrane invagination ISS --
GO:0048268 clathrin coat assembly IMP 20448150
GO:0072583 clathrin-mediated endocytosis IMP 20448150
GO:0072659 protein localization to plasma membrane ISS --
genes like me logo Genes that share ontologies with FCHO2: view

No data available for Pathways by source for FCHO2 Gene

Transcripts for FCHO2 Gene

Unigene Clusters for FCHO2 Gene

FCH domain only 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCHO2 Gene

No ASD Table

Relevant External Links for FCHO2 Gene

GeneLoc Exon Structure for
FCHO2
ECgene alternative splicing isoforms for
FCHO2

Expression for FCHO2 Gene

mRNA expression in normal human tissues for FCHO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FCHO2 Gene

SOURCE GeneReport for Unigene cluster for FCHO2 Gene Hs.165762

genes like me logo Genes that share expressions with FCHO2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FCHO2 Gene

Orthologs for FCHO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCHO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCHO2 35
  • 99.71 (n)
  • 99.63 (a)
FCHO2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCHO2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCHO2 35
  • 93.84 (n)
  • 96.82 (a)
FCHO2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcho2 35
  • 90.03 (n)
  • 94.81 (a)
Fcho2 16
Fcho2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCHO2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fcho2 35
  • 90.94 (n)
  • 95.18 (a)
chicken
(Gallus gallus)
Aves FCHO2 35
  • 82.24 (n)
  • 86.9 (a)
lizard
(Anolis carolinensis)
Reptilia FCHO2 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33576 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fcho2 35
  • 74.78 (n)
  • 79.23 (a)
Str.1488 35
zebrafish
(Danio rerio)
Actinopterygii fcho2 35
  • 66.54 (n)
  • 70.98 (a)
sbcb304 35
si:dkey-24m12.3 36
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002024 35
  • 52.01 (n)
  • 47.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8176 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fcho-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for FCHO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FCHO2 Gene

ENSEMBL:
Gene Tree for FCHO2 (if available)
TreeFam:
Gene Tree for FCHO2 (if available)

Paralogs for FCHO2 Gene

Paralogs for FCHO2 Gene

Pseudogenes.org Pseudogenes for FCHO2 Gene

genes like me logo Genes that share paralogs with FCHO2: view

Variants for FCHO2 Gene

Sequence variations from dbSNP and Humsavar for FCHO2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26575 -- 72,998,631(+) AGAGG(A/G)TTAAA intron-variant
rs26576 -- 73,002,429(+) CATGT(A/C)GTCAT intron-variant
rs26577 -- 73,003,212(+) TCTTG(C/T)TATGT intron-variant
rs27952 -- 73,020,610(-) CAACC(C/T)ATCAT intron-variant
rs30532 -- 73,039,881(+) CGAGA(C/T)GATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCHO2 Gene

Variant ID Type Subtype PubMed ID
nsv882180 CNV Loss 21882294
nsv525479 CNV Loss 19592680
nsv830343 CNV Loss 17160897
esv27712 CNV Loss 19812545
esv2730298 CNV Deletion 23290073
esv2730299 CNV Deletion 23290073
esv267630 CNV Insertion 20981092
esv274596 CNV Insertion 20981092

Relevant External Links for FCHO2 Gene

HapMap Linkage Disequilibrium report
FCHO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCHO2 Gene

Disorders for FCHO2 Gene

Relevant External Links for FCHO2

Genetic Association Database (GAD)
FCHO2
genes like me logo Genes that share disorders with FCHO2: view

No data available for UniProtKB/Swiss-Prot for FCHO2 Gene

Publications for FCHO2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico. (PMID: 15254787) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for FCHO2 Gene

  • antibodies-online peptides for FCHO2
  • antibodies-online antibodies for FCHO2
  • antibodies-online kits for FCHO2

Sources for FCHO2 Gene

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