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Aliases for FCHO2 Gene

Aliases for FCHO2 Gene

  • FCH Domain Only 2 2 3 5

External Ids for FCHO2 Gene

Previous GeneCards Identifiers for FCHO2 Gene

  • GC05P072287
  • GC05P067457

Summaries for FCHO2 Gene

GeneCards Summary for FCHO2 Gene

FCHO2 (FCH Domain Only 2) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. GO annotations related to this gene include phosphatidylinositol binding and phosphatidylserine binding. An important paralog of this gene is FCHO1.

UniProtKB/Swiss-Prot for FCHO2 Gene

  • Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.

Gene Wiki entry for FCHO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCHO2 Gene

Genomics for FCHO2 Gene

Regulatory Elements for FCHO2 Gene

Enhancers for FCHO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F072953 0.7 ENCODE 25.3 -0.4 -435 4.8 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP5 REST FCHO2 UTP15 PTCD2 RPL7P22 ENSG00000249085 ENSG00000272081 ENSG00000271926
GH05F072840 1.4 FANTOM5 Ensembl ENCODE 24.4 -113.1 -113077 4.0 TBP HDAC1 ATF1 PKNOX1 SIN3A BRCA1 RAD21 GTF3C2 GATA2 ELK1 FCHO2 ENSG00000249085 UTP15 TNPO1 PTCD2 ANKRA2 ARHGEF28 GC05P072869
GH05F072319 0.5 ENCODE 22.5 -635.6 -635613 2.7 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FCHO2 PTCD2 RPL7P22 RPL10AP8 MRPS27
GH05F072939 1.1 FANTOM5 Ensembl 22.1 -15.8 -15781 0.8 PKNOX1 MAFG ZNF843 GATA3 ZNF316 IKZF1 PBX2 KDM1A MAFK EMSY FCHO2 ENSG00000249085 ENSG00000272081 ENSG00000271926 GC05M072921
GH05F073495 1.1 ENCODE 19.7 +542.1 542143 5.1 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF207 UTP15 ANKRA2 FCHO2 ENSG00000272525 RPL7P22 BTF3 GC05M073449
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FCHO2 on UCSC Golden Path with GeneCards custom track

Promoters for FCHO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001282570 719 3401 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP5 REST
ENSR00001870305 -1281 201 ZNF740

Genomic Location for FCHO2 Gene

Chromosome:
5
Start:
72,955,981 bp from pter
End:
73,090,522 bp from pter
Size:
134,542 bases
Orientation:
Plus strand

Genomic View for FCHO2 Gene

Genes around FCHO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCHO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCHO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCHO2 Gene

Proteins for FCHO2 Gene

  • Protein details for FCHO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0JRZ9-FCHO2_HUMAN
    Recommended name:
    F-BAR domain only protein 2
    Protein Accession:
    Q0JRZ9
    Secondary Accessions:
    • A8K6W7
    • B2RNQ9
    • B4DHK0
    • E9PG79
    • Q0JTJ3
    • Q96CF5

    Protein attributes for FCHO2 Gene

    Size:
    810 amino acids
    Molecular mass:
    88924 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R, ITSN1 and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex AP-2 at the plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis.
    Miscellaneous:
    • Deforms liposomes into a range of tubule diameters from 20 to 130 nm in vitro.
    SequenceCaution:
    • Sequence=AAH14311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCHO2 Gene

    Alternative splice isoforms for FCHO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCHO2 Gene

Post-translational modifications for FCHO2 Gene

  • Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity).
  • Ubiquitination at Lys 58
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCHO2 Gene

Domains & Families for FCHO2 Gene

Gene Families for FCHO2 Gene

Protein Domains for FCHO2 Gene

Suggested Antigen Peptide Sequences for FCHO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0JRZ9

UniProtKB/Swiss-Prot:

FCHO2_HUMAN :
  • Contains 1 F-BAR domain.
  • Belongs to the FCHO family.
Domain:
  • Contains 1 F-BAR domain.
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the FCHO family.
genes like me logo Genes that share domains with FCHO2: view

Function for FCHO2 Gene

Molecular function for FCHO2 Gene

UniProtKB/Swiss-Prot Function:
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.

Gene Ontology (GO) - Molecular Function for FCHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding ISS --
GO:0005515 protein binding IPI 19380743
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
GO:0035091 phosphatidylinositol binding ISS --
genes like me logo Genes that share ontologies with FCHO2: view
genes like me logo Genes that share phenotypes with FCHO2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCHO2 Gene

Localization for FCHO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCHO2 Gene

Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCHO2 Gene COMPARTMENTS Subcellular localization image for FCHO2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FCHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005905 clathrin-coated pit IEA,IDA 21762413
GO:0016020 membrane IEA --
GO:0030136 clathrin-coated vesicle IDA 21762413
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with FCHO2: view

Pathways & Interactions for FCHO2 Gene

genes like me logo Genes that share pathways with FCHO2: view

Gene Ontology (GO) - Biological Process for FCHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0010324 membrane invagination ISS --
GO:0048268 clathrin coat assembly IMP 20448150
GO:0048488 synaptic vesicle endocytosis IEA --
GO:0072583 clathrin-dependent endocytosis IMP 20448150
genes like me logo Genes that share ontologies with FCHO2: view

No data available for SIGNOR curated interactions for FCHO2 Gene

Transcripts for FCHO2 Gene

Unigene Clusters for FCHO2 Gene

FCH domain only 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCHO2 Gene

No ASD Table

Relevant External Links for FCHO2 Gene

GeneLoc Exon Structure for
FCHO2
ECgene alternative splicing isoforms for
FCHO2

Expression for FCHO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCHO2 Gene

Protein differential expression in normal tissues from HIPED for FCHO2 Gene

This gene is overexpressed in Cervix (23.0), Plasma (9.4), Spleen (7.4), and Serum (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FCHO2 Gene



NURSA nuclear receptor signaling pathways regulating expression of FCHO2 Gene:

FCHO2

SOURCE GeneReport for Unigene cluster for FCHO2 Gene:

Hs.165762
genes like me logo Genes that share expression patterns with FCHO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FCHO2 Gene

Orthologs for FCHO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCHO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCHO2 34 35
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia FCHO2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCHO2 34 35
  • 93.84 (n)
rat
(Rattus norvegicus)
Mammalia Fcho2 34
  • 90.94 (n)
mouse
(Mus musculus)
Mammalia Fcho2 34 16 35
  • 90.03 (n)
oppossum
(Monodelphis domestica)
Mammalia FCHO2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FCHO2 34
  • 82.24 (n)
lizard
(Anolis carolinensis)
Reptilia FCHO2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fcho2 34
  • 74.78 (n)
Str.1488 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33576 34
zebrafish
(Danio rerio)
Actinopterygii fcho2 34
  • 66.54 (n)
si:dkey-24m12.3 35
  • 33 (a)
ManyToMany
sbcb304 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002024 34
  • 52.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8176 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fcho-1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for FCHO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FCHO2 Gene

ENSEMBL:
Gene Tree for FCHO2 (if available)
TreeFam:
Gene Tree for FCHO2 (if available)

Paralogs for FCHO2 Gene

Paralogs for FCHO2 Gene

Pseudogenes.org Pseudogenes for FCHO2 Gene

genes like me logo Genes that share paralogs with FCHO2: view

Variants for FCHO2 Gene

Sequence variations from dbSNP and Humsavar for FCHO2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035287 -- 73,028,449(+) tagta(C/G)ctcca intron-variant
rs10043312 -- 73,061,493(+) TAGAG(C/T)AGAGT intron-variant
rs10043933 -- 72,993,902(+) attca(A/G)taaat intron-variant
rs10054236 -- 73,038,851(+) ATCTG(A/C)TCAAT intron-variant
rs10062008 -- 73,077,681(+) aaaaa(A/G)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCHO2 Gene

Variant ID Type Subtype PubMed ID
esv2730298 CNV deletion 23290073
esv2730299 CNV deletion 23290073
esv27712 CNV loss 19812545
esv3310324 CNV mobile element insertion 20981092
esv3358480 CNV insertion 20981092
esv3394174 CNV insertion 20981092
esv3605410 CNV loss 21293372
nsv525479 CNV loss 19592680
nsv830343 CNV loss 17160897
nsv980683 CNV duplication 23825009

Variation tolerance for FCHO2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCHO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCHO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCHO2 Gene

Disorders for FCHO2 Gene

Relevant External Links for FCHO2

Genetic Association Database (GAD)
FCHO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCHO2

No disorders were found for FCHO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCHO2 Gene

Publications for FCHO2 Gene

  1. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. (PMID: 22323290) Mulkearns E.E. … Cooper J.A. (Mol. Biol. Cell 2012) 3 4 64
  2. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. (PMID: 22484487) Umasankar P.K. … Traub L.M. (Nat. Cell Biol. 2012) 3 4 64
  3. Characterization of the EFC/F-BAR domain protein, FCHO2. (PMID: 21762413) Uezu A. … Nakanishi H. (Genes Cells 2011) 3 4 64
  4. FCHo proteins are nucleators of clathrin-mediated endocytosis. (PMID: 20448150) Henne W.M. … McMahon H.T. (Science 2010) 3 4 64
  5. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. (PMID: 17540576) Henne W.M. … McMahon H.T. (Structure 2007) 3 4 64

Products for FCHO2 Gene

Sources for FCHO2 Gene

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