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FCHO2 Gene

protein-coding   GIFtS: 52
GCID: GC05P072287

FCH Domain Only 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FCH Domain Only 21 2
FCH Domain Only Protein 22

External Ids:    HGNC: 251801   Entrez Gene: 1155482   Ensembl: ENSG000001571077   OMIM: 6134385   UniProtKB: Q0JRZ93   

Export aliases for FCHO2 gene to outside databases

Previous GC identifer: GC05P067457


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FCHO2 Gene:
FCHO2 (FCH domain only 2) is a protein-coding gene. Diseases associated with FCHO2 include pulmonary function, and malaria. GO annotations related to this gene include phosphatidylserine binding and phosphatidylinositol binding. An important paralog of this gene is SGIP1.

UniProtKB/Swiss-Prot: FCHO2_HUMAN, Q0JRZ9
Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending
activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a
lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides
(Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the
subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor
protein complex AP-2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent
endocytosis of the LDL receptor

Gene Wiki entry for FCHO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCHO2 gene promoter:
         GR   Elk-1   Pbx1a   NF-YA   Roaz   FOXL1   Arnt   NF-YB   SRY   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCHO2 promoter sequence
   Search Chromatin IP Primers for FCHO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCHO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

FCHO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCHO2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072287:  view genomic region     (about GC identifiers)

Start:
72,251,808 bp from pter      End:
72,386,349 bp from pter
Size:
134,542 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FCHO2_HUMAN, Q0JRZ9 (See protein sequence)
Recommended Name: FCH domain only protein 2  
Size: 810 amino acids; 88924 Da
Subunit: Homodimer; disulfide-linked. May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R,
ITSN1 and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex
AP-2 at the plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis
Miscellaneous: Deforms liposomes into a range of tubule diameters from 20 to 130 nm in vitro
Sequence caution: Sequence=AAH14311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for FCHO2:
2V0O (3D)    
Secondary accessions: A8K6W7 B2RNQ9 B4DHK0 E9PG79 Q0JTJ3 Q96CF5
Alternative splicing: 3 isoforms:  Q0JRZ9-1   Q0JRZ9-2   Q0JRZ9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCHO2: NX_Q0JRZ9

Explore proteomics data for FCHO2 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity)1
  • Ubiquitination2 at Lys58
  • Modification sites at PhosphoSitePlus

  • See FCHO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139504.1  NP_620137.2  

    ENSEMBL proteins: 
     ENSP00000393776   ENSP00000426842   ENSP00000427296   ENSP00000287761   ENSP00000344034  

    FCHO2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001060 FCH_dom
     IPR018808 Muniscin_C
     IPR028565 MHD

    Graphical View of Domain Structure for InterPro Entry Q0JRZ9

    ProtoNet protein and cluster: Q0JRZ9

    1 Blocks protein domain: IPB001060 Cdc15/Fes/CIP4

    UniProtKB/Swiss-Prot: FCHO2_HUMAN, Q0JRZ9
    Similarity: Belongs to the FCHO family
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 MHD (mu homology) domain


    FCHO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCHO2_HUMAN, Q0JRZ9
    Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending
    activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a
    lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides
    (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the
    subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor
    protein complex AP-2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent
    endocytosis of the LDL receptor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding ISS--
    GO:0005515protein binding IPI19380743
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS--
    GO:0035091phosphatidylinositol binding ISS--
         
    FCHO2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FCHO2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCHO2
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    miRNA
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    miRTarBase miRNAs that target FCHO2:
    hsa-mir-124-3p (MIRT002703), hsa-mir-181d-5p (MIRT041166), hsa-mir-93-5p (MIRT028083)

    Block miRNA regulation of human, mouse, rat FCHO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FCHO2 (see all 40):
    hsa-miR-140-5p hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-124 hsa-miR-298 hsa-miR-4325 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidFCHO2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FCHO2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCHO2_HUMAN, Q0JRZ9: Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (By
    similarity). Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits
    precede the one of clathrin and the adaptor protein complex AP-2 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0005905coated pit IDA--
    GO:0030136clathrin-coated vesicle IDA--

    FCHO2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCHO2
    Interactions:

        Search GeneGlobe Interaction Network for FCHO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FCHO2 (Q0JRZ91, 3 ENSP000003937764) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS15P425661, 3, ENSP000003607984EBI-2609756,EBI-396684 I2D: score=1 STRING: ENSP00000360798
    ITSN2Q9NZM33I2D: score=1 
    AP2A1ENSP000003519264STRING: ENSP00000351926
    AP2A2ENSP000004132344STRING: ENSP00000413234
    KYENSP000003975984STRING: ENSP00000397598
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010324membrane invagination ISS--
    GO:0048268clathrin coat assembly IMP--
    GO:0072583clathrin-mediated endocytosis IMP--
    GO:0072659protein localization to plasma membrane ISS--

    FCHO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCHO2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FCHO2 gene (2 alternative transcripts): 
    NM_001146032.1  NM_138782.2  

    Unigene Cluster for FCHO2:

    FCH domain only 2
    Hs.165762  [show with all ESTs]
    Unigene Representative Sequence: NM_138782
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430046(uc003kcl.3 uc011csl.2 uc010izb.3 uc011csn.2)
    ENST00000507345 ENST00000512348 ENST00000287761(uc011csk.1) ENST00000511264
    ENST00000503302 ENST00000508431 ENST00000341845
    miRNA
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    Block miRNA regulation of human, mouse, rat FCHO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FCHO2 (see all 40):
    hsa-miR-140-5p hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-124 hsa-miR-298 hsa-miR-4325 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidFCHO2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): FCHO2 (NM_138782)
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      QuantiTect SYBR Green Assays in human, mouse, rat FCHO2
      QuantiFast Probe-based Assays in human, mouse, rat FCHO2

    Additional mRNA sequence: 

    AK291782.1 AK293796.1 AK295141.1 AL831971.1 AL832928.1 AL833313.1 BC006004.1 BC014311.1 
    BC137070.1 

    9 DOTS entries:

    DT.99941281  DT.120837529  DT.111191  DT.91994474  DT.120837613  DT.91647753  DT.102834050  DT.40240803 
    DT.92033484 

    Selected AceView cDNA sequences (see all 88):

    BX279825 BX482737 AI673714 BU682709 AI183688 AI979184 CD722583 BU684309 
    AA577231 CA436243 AW150671 AV708247 BU509356 AL832928 BQ026097 BX447395 
    AI401505 BG482756 AI627666 BM848943 BG619166 AI520959 BE677935 BX452153 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCHO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATATATAA
    FCHO2 Expression
    About this image


    FCHO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    FCHO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCHO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.165762
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FCHO2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcho21 , 5 FCH domain only 21, 5 90.03(n)1
    94.81(a)1
      13 (52.16 cM)5
    2185031  NM_172591.31  NP_766179.21 
     987234075 
    chicken
    (Gallus gallus)
    Aves FCHO21 FCH domain only 2 82.24(n)
    86.9(a)
      769464  XM_001232743.3  XP_001232744.3 
    lizard
    (Anolis carolinensis)
    Reptilia FCHO26
    FCH domain only 2
    81(a)
    1 ↔ 1
    2(16170494-16252029)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.335762 Xenopus laevis transcribed sequence with weak similarity more 76.71(n)    BJ611998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3042 sbcb304 73.82(n)   321196  BC058060.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81766
    --
    24(a)
    1 → many
    3R(5341758-5352964)
    worm
    (Caenorhabditis elegans)
    Secernentea fcho-16
    Protein F56D12.6, isoform a (F56D12.6) mRNA, compl...
    22(a)
    1 → many
    II(1310535-1320438) WBGene00018974


    ENSEMBL Gene Tree for FCHO2 (if available)
    TreeFam Gene Tree for FCHO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCHO2 gene
    SGIP12  FCHO12  
    18 SIMAP similar genes for FCHO2 using alignment to 5 protein entries:     FCHO2_HUMAN (see all proteins):
    NF2    FCHO1    C17orf86    FP1523    PTPLA    FAM175A
    SGIP1    PSTPIP1    AURA2    MED15    UTY    PSTPIP2
    SEPT2    LINC00596    LYRM4    TMEM14B    ZNF564    SHANK2

    FCHO2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FCHO2
    PGOHUM00000235245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCHO2 (see all 2331)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs578204981,2
    C--67512388(+) AAAAA-/A/AA  
            
    GAGAG
    2 -- int11NA 2
    rs1459653021,2
    --72250129(+) AGCCAC/TGCTAT 2 -- us2k10--------
    rs68656581,2
    C,F--72250310(+) TTTTTT/AAAATT 2 -- us2k1 tfbs32Minor allele frequency- A:0.04WA NA 238
    rs1385663671,2
    C--72250452(+) GGAATG/TTAATG 2 -- us2k10--------
    rs1154093141,2
    C,F--72250539(+) ACCGAT/CAGCTT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1167090421,2
    C,F--72250581(+) TTCCCT/CAAAAC 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1816983071,2
    --72250585(+) CTAAAA/GCTAAG 2 -- us2k10--------
    rs1145266311,2
    F--72250609(+) GATATG/AAGGAC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1860924631,2
    --72250640(+) AGAAAC/GAAGAT 2 -- us2k10--------
    rs1915943561,2
    --72250667(+) ACTATA/GGCCAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCHO2 (72251808 - 72386349 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FCHO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730299CNV Deletion23290073
    esv2730298CNV Deletion23290073
    esv267630CNV Insertion20981092
    esv274596CNV Insertion20981092
    esv27712CNV Loss19812545
    nsv830343CNV Loss17160897
    nsv882180CNV Loss21882294
    nsv525479CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613438    OMIM disorders: --

    2 diseases for FCHO2:    
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    pulmonary function    malaria


    FCHO2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FCHO2

    Export disorders for FCHO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCHO2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with FCHO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. (PubMed id 22323290)1, 2 Mulkearns E.E. and Cooper J.A. (Mol. Biol. Cell 2012)
    2. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. (PubMed id 22484487)1, 2 Umasankar P.K.... Traub L.M. (Nat. Cell Biol. 2012)
    3. Characterization of the EFC/F-BAR domain protein, FCHO2. (PubMed id 21762413)1, 2 Uezu A.... Nakanishi H. (Genes Cells 2011)
    4. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. (PubMed id 17540576)1, 2 Henne W.M.... McMahon H.T. (Structure 2007)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico. (PubMed id 15254787)1, 3 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115548 HGNC: 25180 AceView: FCHO2 Ensembl:ENSG00000157107 euGenes: HUgn115548
    ECgene: FCHO2 H-InvDB: FCHO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCHO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCHO2 gene:
    Search GeneIP for patents involving FCHO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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