Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCHO2 Gene

protein-coding   GIFtS: 47
GCID: GC05P072287

FCH domain only 2

  Search for FCHO2
in our new
 Human Malady Compendium 
Biological research products
for FCHO2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
FCH Domain Only 21 2
FCH Domain Only Protein 22

External Ids:    HGNC: 251801   Entrez Gene: 1155482   Ensembl: ENSG000001571077   OMIM: 6134385   UniProtKB: Q0JRZ93   

Export aliases for FCHO2 gene to outside databases

Previous GC identifer: GC05P067457


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FCHO2_HUMAN, Q0JRZ9
Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and
the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding
activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate)
like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and
adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis
of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor

Gene Wiki entry for FCHO2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCHO2 gene promoter:
         GR   Elk-1   Pbx1a   NF-YA   Roaz   FOXL1   Arnt   NF-YB   SRY   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCHO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FCHO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCHO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

FCHO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCHO2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072287:  view genomic region     (about GC identifiers)

Start:
72,251,808 bp from pter      End:
72,386,349 bp from pter
Size:
134,542 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCHO2_HUMAN, Q0JRZ9 (See protein sequence)
Recommended Name: FCH domain only protein 2  
Size: 810 amino acids; 88924 Da
Subunit: Homodimer; disulfide-linked. May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R, ITSN1
and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex AP-2 at the
plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis
Subcellular location: Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity).
Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one
of clathrin and the adaptor protein complex AP-2 (By similarity)
Miscellaneous: Deforms liposomes into a range of tubule diameters from 20 to 130 nm in vitro
Sequence caution: Sequence=AAH14311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for FCHO2:
2V0O (3D)    
Secondary accessions: A8K6W7 B2RNQ9 B4DHK0 E9PG79 Q0JTJ3 Q96CF5
Alternative splicing: 3 isoforms:  Q0JRZ9-1   Q0JRZ9-2   Q0JRZ9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCHO2: NX_Q0JRZ9

Post-translational modifications:

  • Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q0JRZ9

  • FCHO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139504.1  NP_620137.2  

    ENSEMBL proteins: 
     ENSP00000393776   ENSP00000427296   ENSP00000287761   ENSP00000426842   ENSP00000344034  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for FCHO2 
    GenScript Custom Purified and Recombinant Proteins Services for FCHO2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FCHO2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0005905coated pit IDA--
    GO:0030136clathrin-coated vesicle IDA--


    FCHO2 for ontologies           About GeneDecksing



    FCHO2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FCHO2 
    GenScript Custom Superior Antibodies Services for FCHO2
    Novus Biologicals FCHO2 Antibodies
    Search for Antibodies for FCHO2 at Abcam  
    Uscn Antibodies for FCHO2
    Search ThermoFisher Antibodies for FCHO2

    Assay Products for FCHO2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FCHO2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FCHO2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FCHO2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001060 FCH
     IPR018808 Muniscin_C-term_mu_dom

    Graphical View of Domain Structure for InterPro Entry Q0JRZ9

    ProtoNet protein and cluster: Q0JRZ9

    1 Blocks protein family: IPB001060 Cdc15/Fes/CIP4

    UniProtKB/Swiss-Prot: FCHO2_HUMAN, Q0JRZ9
    Similarity: Belongs to the FCHO family
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 MUHD (Muniscin C-terminal mu homology domain) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FCHO2_HUMAN, Q0JRZ9
    Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and
    the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding
    activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate)
    like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and
    adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis
    of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor

    miRNA
    Products:
        
    miRTarBase miRNAs that target FCHO2:
    hsa-mir-124 (MIRT002703)

    OriGene 3'-UTR Clone (see all 2): FCHO2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCHO2
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate FCHO2 (see all 40):
    hsa-miR-140-5p hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-124 hsa-miR-298 hsa-miR-4325 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidFCHO2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCHO2 (see all 4)
    OriGene siRNA: FCHO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCHO2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCHO2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCHO2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCHO2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FCHO2 (NM_138782)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCHO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHO2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCHO2
    Search LifeMap BioReagents cell lines for FCHO2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding ISS--
    GO:0005515protein binding IPI--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS--
    GO:0035091phosphatidylinositol binding ISS--


    FCHO2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FCHO2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCHO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for FCHO2 (Q0JRZ91, 3 ENSP000003937764) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS15P425661, 3, ENSP000003607984EBI-2609756,EBI-396684 I2D: score=1 STRING: ENSP00000360798
    ITSN2Q9NZM33I2D: score=1 
    AP2A1ENSP000003519264STRING: ENSP00000351926
    AP2A2ENSP000004132344STRING: ENSP00000413234
    ACVR1ENSP000002636404STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010324membrane invagination ISS--
    GO:0048268clathrin coat assembly IMP--
    GO:0072583clathrin-mediated endocytosis IMP--
    GO:0072659protein localization to plasma membrane ISS--


    FCHO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCHO2
    Search CenterWatch for drugs/clinical trials and news about FCHO2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCHO2 gene (2 alternative transcripts): 
    NM_001146032.1  NM_138782.2  

    Unigene Cluster for FCHO2:

    FCH domain only 2
    Hs.741336  [show with all ESTs]
    Unigene Representative Sequence: NM_138782
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430046(uc003kcl.3 uc011csl.2 uc010izb.3 uc011csn.2)
    ENST00000512348 ENST00000287761(uc011csk.1) ENST00000507345 ENST00000511264
    ENST00000503302 ENST00000508431 ENST00000341845

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): FCHO2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCHO2
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate FCHO2 (see all 40):
    hsa-miR-140-5p hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-124 hsa-miR-298 hsa-miR-4325 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidFCHO2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCHO2 (see all 4)
    OriGene siRNA: FCHO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCHO2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCHO2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCHO2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FCHO2 (NM_138782)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCHO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHO2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCHO2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCHO2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCHO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCHO2

    Additional cDNA sequence: 

    AK291782.1 AK293796.1 AK295141.1 AL831971.1 AL832928.1 AL833313.1 BC006004.1 BC014311.1 
    BC137070.1 

    9 DOTS entries:

    DT.99941281  DT.120837529  DT.111191  DT.91994474  DT.120837613  DT.91647753  DT.102834050  DT.40240803 
    DT.92033484 

    24/88 AceView cDNA sequences (see all 88):

    CD722583 AV708247 AI979184 AI673714 AI183688 BU682709 BX482737 AW150671 
    BX279825 AA577231 CA436243 BU509356 AL832928 BQ026097 BU684309 AL831971 
    BI772302 BX283153 BI754922 AW273301 AL833313 BM699071 BF431022 BX104706 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCHO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATATATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FCHO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCHO2

    SOURCE GeneReport for Unigene cluster: Hs.741336
        SABiosciences Custom PCR Arrays for FCHO2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCHO2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCHO2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCHO2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCHO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FCHO2 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcho21 , 5 FCH domain only 21, 5 90.23(n)1
    94.93(a)1
      13 (52.16 cM)5
    2185031  NM_172591.31  NP_766179.21 
     987234075 
    chicken
    (Gallus gallus)
    Aves FCHO21 FCH domain only 2 82.24(n)
    87.02(a)
      769464  XM_001232743.2  XP_001232744.2 
    lizard
    (Anolis carolinensis)
    Reptilia FCHO26
    --
    83(a)
    1 ↔ 1
    2(16166623-16235143)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.335762 Xenopus laevis transcribed sequence with weak similarity more 76.71(n)    BJ611998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3042 sbcb304 73.82(n)   321196  BC058060.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81761 CG8176 48.76(n)
    43.13(a)
      261329  NM_001104254.1  NP_001097724.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F56D12.61 Protein F56D12.6 44.2(n)
    31.77(a)
      173511  NM_061547.2  NP_493948.1 


    ENSEMBL Gene Tree for FCHO2 (if available)
    TreeFam Gene Tree for FCHO2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCHO2 gene
    FCHO12  SGIP12  
    18 SIMAP similar genes for FCHO2 using alignment to 5 protein entries:     FCHO2_HUMAN (see all proteins):
    NF2    C17orf86    FP1523    PTPLA    FCHO1    FAM175A
    SGIP1    PSTPIP1    AURA2    MED15    UTY    PSTPIP2
    SEPT2    LINC00596    LYRM4    TMEM14B    ZNF564    SHANK2

    FCHO2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FCHO2
    PGOHUM00000235245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1911 NCBI SNPs in FCHO2 are shown (see all 1911    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459653021,2
    --72250129(+) AGCCAC/TGCTAT 2 -- us2k10--------
    rs68656581,2
    C,F,--72250310(+) TTTTTT/AAAATT 2 -- us2k1 tfbs32Minor allele frequency- A:0.04WA NA 238
    rs1385663671,2
    --72250452(+) GGAATG/TTAATG 2 -- us2k10--------
    rs1154093141,2
    F,--72250539(+) ACCGAT/CAGCTT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1167090421,2
    F,--72250581(+) TTCCCT/CAAAAC 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1816983071,2
    --72250585(+) CTAAAA/GCTAAG 2 -- us2k10--------
    rs1145266311,2
    F,--72250609(+) GATATG/AAGGAC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1860924631,2
    --72250640(+) AGAAAC/GAAGAT 2 -- us2k10--------
    rs1915943561,2
    --72250667(+) ACTATA/GGCCAA 2 -- us2k10--------
    rs1416577561,2
    --72250766(+) TATATC/TTTTCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCHO2 (72251808 - 72386349 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FCHO2
         1 CNV: 69146

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCHO2
    DNA2.0 Custom Variant and Variant Library Synthesis for FCHO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FCHO2 for disorders           About MalaCards

    FCHO2 for disorders           About GeneDecksing

    OMIM gene information: 613438    OMIM disorders: --


    Export disorders for FCHO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCHO2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with FCHO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. (PubMed id 22323290)1, 2 Mulkearns E.E. and Cooper J.A. (2012)
    2. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. (PubMed id 22484487)1, 2 Umasankar P.K.... Traub L.M. (2012)
    3. Characterization of the EFC/F-BAR domain protein, FCH O2. (PubMed id 21762413)1, 2 Uezu A....Nakanishi H. (2011)
    4. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. (PubMed id 17540576)1, 2 Henne W.M.... McMahon H.T. (2007)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico. (PubMed id 15254787)1, 3 Katoh M. and Katoh M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115548 HGNC: 25180 AceView: FCHO2 Ensembl:ENSG00000157107 euGenes: HUgn115548
    ECgene: FCHO2 H-InvDB: FCHO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCHO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCHO2 gene:
    Search GeneIP for patents involving FCHO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCHO2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCHO2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FCHO2   OriGene 3'-UTR Clone for FCHO2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCHO2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCHO2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCHO2   OriGene Custom Protein Services for FCHO2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCHO2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCHO2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCHO2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCHO2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCHO2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCHO2
     GenScript Custom Purified and Recombinant Proteins Services for FCHO2 GenScript cDNA clones with any tag delivered in your preferred vector for FCHO2
     GenScript Custom Assay Services for FCHO2 GenScript Custom Superior Antibodies Services for FCHO2
     GenScript Custom overexpressing Cell Line Services for FCHO2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FCHO2 promoter
     Search Chromatin IP Primers for FCHO2
     RT2 qPCR Primer Assay in human, mouse, rat FCHO2
     Search GNC Networks for FCHO2
     SABiosciences Custom PCR Arrays for FCHO2
     Search Tocris compounds for FCHO2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FCHO2 antibodies
     Search for Antibodies for FCHO2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FCHO2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FCHO2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FCHO2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO2
     SwitchGear 3'UTR luciferase reporter plasmids for FCHO2
     SwitchGear Promoter luciferase reporter plasmids for FCHO2
     Search ThermoFisher Antibodies for FCHO2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHO2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FCHO2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4