Aliases for FCHO1 Gene
External Ids for FCHO1 Gene
- HGNC: 29002
- Entrez Gene: 23149
- Ensembl: ENSG00000130475
- OMIM: 613437
- UniProtKB: O14526
Previous GeneCards Identifiers for FCHO1 Gene
- GC19P017723
- GC19P017599
- GC19P017862
- GC19P017423
- GC19P017956
- GC19P017748
- GC19P018221
- GC19P018326
- GC19P018698
Summaries for FCHO1 Gene
GeneCards Summary for FCHO1 Gene
FCHO1 (FCH Domain Only 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. GO annotations related to this gene include AP-2 adaptor complex binding. An important paralog of this gene is FCHO2.
UniProtKB/Swiss-Prot for FCHO1 Gene
-
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCHO1 Gene
Genomics for FCHO1 Gene
Regulatory Elements for FCHO1 Gene
- Transcription factor binding sites by QIAGEN in the FCHO1 gene promoter:
Regulatory Element Products
Genomic Location for FCHO1 Gene
- Chromosome:
- 19
- Start:
- 17,747,718 bp from pter
- End:
- 17,788,568 bp from pter
- Size:
- 40,851 bases
- Orientation:
- Plus strand
Genomic View for FCHO1 Gene
- Cytogenetic band:
-
- 19p13.11 by Ensembl
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCHO1 Gene
Proteins for FCHO1 Gene
-
Protein details for FCHO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14526-FCHO1_HUMAN
- Recommended name:
- F-BAR domain only protein 1
- Protein Accession:
- O14526
- A6NHE6
- A8K5U5
- B4E120
- Q05C93
- Q8IW22
Protein attributes for FCHO1 Gene
- Size:
- 889 amino acids
- Molecular mass:
- 96861 Da
- Quaternary structure:
-
- May oligomerize and form homotetramer (By similarity). Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2. Interacts with DAB2. Interacts with clathrin (CLTC or CLTCL1). Interacts with EPS15, EPS15R and ITSN1. Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis.
- SequenceCaution:
-
- Sequence=BAA22959.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FCHO1 Gene
Post-translational modifications for FCHO1 Gene
Other Protein References for FCHO1 Gene
- ENSEMBL proteins:
-
- ENSP00000469075
- ENSP00000469425
- ENSP00000469458
- ENSP00000469511
- ENSP00000469711
- ENSP00000469967
- ENSP00000470068
- ENSP00000470493
- ENSP00000470495
- ENSP00000470511
- ENSP00000470568
- ENSP00000470578
- ENSP00000470730
- ENSP00000470731
- ENSP00000471003
- ENSP00000471450
- ENSP00000471563
- ENSP00000471935
- ENSP00000472417
- ENSP00000472623
- ENSP00000472668
- ENSP00000473001
- ENSP00000473169
- ENSP00000473173
- ENSP00000252771
- REFSEQ proteins:
-
- NP_001154829.1
- NP_001154830.1
- NP_001154831.1
- NP_055937.1
- XP_005259888.1
- XP_006722764.1
- XP_006722765.1
- XP_011526126.1
- XP_011526127.1
- XP_011526128.1
- XP_011526129.1
- XP_011526130.1
- XP_016882008.1
- XP_016882009.1
- XP_016882010.1
- XP_016882011.1
- XP_016882012.1
- XP_016882013.1
- XP_016882014.1
- XP_016882015.1
- XP_016882016.1
- XP_016882017.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FCHO1
- Novus Biologicals Antibodies for FCHO1
-
Abcam antibodies for FCHO1
- Invitrogen Antibodies for FCHO1
- antibodies-online Antibodies for FCHO1: See all 23
- GeneTex FCHO1 antibody for FCHO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FCHO1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FCHO1
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- Search GeneTex for Proteins for FCHO1
Assay Products
No data available for DME Specific Peptides for FCHO1 Gene
Domains & Families for FCHO1 Gene
Gene Families for FCHO1 Gene
Protein Domains for FCHO1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCHO1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14526- Family:
-
- Belongs to the FCHO family.
Function for FCHO1 Gene
Molecular function for FCHO1 Gene
- UniProtKB/Swiss-Prot Function:
- Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19713939 |
| GO:0035612 | AP-2 adaptor complex binding | IDA | 22484487 |
Phenotypes for FCHO1 Gene
- GenomeRNAi human phenotypes for FCHO1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FCHO1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCHO1 gene
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CRISPR Products
-
OriGene CRISPR knockouts for FCHO1
-
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miRNA Products
- Search ViGene Biosciences for FCHO1
Inhibitory RNA Products
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-
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Cell Line Products
-
Horizon Cell Lines for FCHO1
-
ViGene Biosciences adenoviral particle packaged cDNA for FCHO1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCHO1 gene
-
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Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12028) for FCHO1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCHO1 Gene
Localization for FCHO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCHO1 Gene
- Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005886 | plasma membrane | IDA | 20448150 |
| GO:0005905 | clathrin-coated pit | IEA,IDA | 20448150 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for FCHO1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Clathrin-mediated endocytosis | ||
| 2 | Vesicle-mediated transport | ||
Pathways by source for FCHO1 Gene
4 Reactome pathways for FCHO1 Gene
Interacting Proteins for FCHO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0048268 | clathrin coat assembly | IMP | 20448150 |
| GO:0061024 | membrane organization | TAS | -- |
| GO:0072583 | clathrin-dependent endocytosis | IEA,IMP | 20448150 |
No data available for SIGNOR curated interactions for FCHO1 Gene
Transcripts for FCHO1 Gene
mRNA/cDNA for FCHO1 Gene
- (22) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (96) Selected AceView cDNA sequences:
- (36) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCHO1 Gene
- FCH domain only 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FCHO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCHO1
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miRNA Products
- Search ViGene Biosciences for FCHO1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCHO1
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-
ViGene Biosciences ready-to-package AAV shRNAs for FCHO1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12028) for FCHO1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||
| SP11: |
Expression for FCHO1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for FCHO1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FCHO1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FCHO1 Gene:
FCHO1SOURCE GeneReport for Unigene cluster for FCHO1 Gene:
Hs.96485Evidence on tissue expression from TISSUES for FCHO1 Gene
- Nervous system(4.7)
- Blood(4.2)
Primer Products
-
OriGene qPCR primer pairs for FCHO1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCHO1 Gene
Orthologs for FCHO1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCHO1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCHO1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCHO1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcho1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FCHO1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FCHO1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FCHO1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fcho1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.26150 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fcho1 34 |
|
||
| FCHO1 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8176 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | fcho-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FCHO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FCHO1 Gene
(3) SIMAP similar genes for FCHO1 Gene using alignment to 19 proteins:
Variants for FCHO1 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000051042 | -- | 17,768,992(+) | AAAAA(A/T)AAGCT | intron-variant | |
| rs1000140049 | -- | 17,779,262(+) | CACGG(A/G)AGGAG | intron-variant | |
| rs1000296448 | -- | 17,785,647(+) | GTTAA(C/T)ATGGT | intron-variant | |
| rs1000321446 | -- | 17,755,928(+) | CAGAG(A/G)TGTGA | intron-variant | |
| rs1000393067 | -- | 17,785,975(+) | AAAAA(-/T)TTTAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv50n68 | CNV | loss | 17160897 |
| nsv1071918 | CNV | deletion | 25765185 |
| nsv1138674 | CNV | deletion | 24896259 |
Relevant External Links for FCHO1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCHO1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCHO1 Gene
Disorders for FCHO1 Gene
Relevant External Links for FCHO1
No disorders were found for FCHO1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCHO1 Gene
Publications for FCHO1 Gene
- Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. (PMID: 22484487) Umasankar P.K. … Traub L.M. (Nat. Cell Biol. 2012) 3 4 64
- FCHo proteins are nucleators of clathrin-mediated endocytosis. (PMID: 20448150) Henne W.M. … McMahon H.T. (Science 2010) 3 4 64
- Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation. (PMID: 17617719) Sakaushi S. … Sugimoto K. (Biosci. Biotechnol. Biochem. 2007) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
Products for FCHO1 Gene
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- VectorBuilder custom plasmid, inducible vectors for FCHO1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCHO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




