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Aliases for FCHO1 Gene

Aliases for FCHO1 Gene

  • FCH Domain Only 1 2 3
  • KIAA0290 4

External Ids for FCHO1 Gene

Summaries for FCHO1 Gene

GeneCards Summary for FCHO1 Gene

FCHO1 (FCH Domain Only 1) is a Protein Coding gene. GO annotations related to this gene include AP-2 adaptor complex binding. An important paralog of this gene is FCHO2.

UniProtKB/Swiss-Prot for FCHO1 Gene

  • Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCHO1 Gene

Genomics for FCHO1 Gene

Genomic Location for FCHO1 Gene

Start:
17,747,718 bp from pter
End:
17,788,568 bp from pter
Size:
40,851 bases
Orientation:
Plus strand

Genomic View for FCHO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCHO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCHO1 Gene

Proteins for FCHO1 Gene

  • Protein details for FCHO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14526-FCHO1_HUMAN
    Recommended name:
    F-BAR domain only protein 1
    Protein Accession:
    O14526
    Secondary Accessions:
    • A6NHE6
    • A8K5U5
    • B4E120
    • Q05C93
    • Q8IW22

    Protein attributes for FCHO1 Gene

    Size:
    889 amino acids
    Molecular mass:
    96861 Da
    Quaternary structure:
    • May oligomerize and form homotetramer (By similarity). Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2. Interacts with DAB2. Interacts with clathrin (CLTC or CLTCL1). Interacts with EPS15, EPS15R and ITSN1. Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis.
    SequenceCaution:
    • Sequence=BAA22959.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FCHO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCHO1 Gene

Proteomics data for FCHO1 Gene at MOPED

Post-translational modifications for FCHO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FCHO1 Gene

Domains for FCHO1 Gene

Protein Domains for FCHO1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FCHO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14526

UniProtKB/Swiss-Prot:

FCHO1_HUMAN
Domain:
  • Contains 1 F-BAR domain.:
    • O14526
  • Contains 1 MHD (mu homology) domain.:
    • O14526
Family:
  • Belongs to the FCHO family.:
    • O14526
genes like me logo Genes that share domains with FCHO1: view

No data available for Gene Families for FCHO1 Gene

Function for FCHO1 Gene

Molecular function for FCHO1 Gene

UniProtKB/Swiss-Prot Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.

Gene Ontology (GO) - Molecular Function for FCHO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19713939
GO:0035612 AP-2 adaptor complex binding IDA 22484487
genes like me logo Genes that share ontologies with FCHO1: view

Phenotypes for FCHO1 Gene

GenomeRNAi human phenotypes for FCHO1:
genes like me logo Genes that share phenotypes with FCHO1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FCHO1 Gene

Localization for FCHO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCHO1 Gene

Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCHO1 Gene COMPARTMENTS Subcellular localization image for FCHO1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FCHO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 20448150
GO:0005905 coated pit IDA 20448150
GO:0030136 NOT colocalizes_with clathrin-coated vesicle IDA 20448150
genes like me logo Genes that share ontologies with FCHO1: view

Pathways for FCHO1 Gene

SuperPathways for FCHO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCHO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048268 clathrin coat assembly IMP 20448150
GO:0072583 clathrin-mediated endocytosis IMP 20448150
genes like me logo Genes that share ontologies with FCHO1: view

No data available for Pathways by source for FCHO1 Gene

Transcripts for FCHO1 Gene

Unigene Clusters for FCHO1 Gene

FCH domain only 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCHO1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: - - - - -
SP7: - -
SP8: - -
SP9:
SP10: - -
SP11:

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for FCHO1 Gene

GeneLoc Exon Structure for
FCHO1
ECgene alternative splicing isoforms for
FCHO1

Expression for FCHO1 Gene

mRNA expression in normal human tissues for FCHO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCHO1 Gene

This gene is overexpressed in Whole Blood (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FCHO1 Gene

SOURCE GeneReport for Unigene cluster for FCHO1 Gene Hs.96485

genes like me logo Genes that share expressions with FCHO1: view

No data available for mRNA Expression by UniProt/SwissProt for FCHO1 Gene

Orthologs for FCHO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCHO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCHO1 35
  • 99.21 (n)
  • 99.55 (a)
FCHO1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCHO1 35
  • 87.67 (n)
  • 90.3 (a)
FCHO1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCHO1 35
  • 89.78 (n)
  • 94.3 (a)
FCHO1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcho1 35
  • 82.87 (n)
  • 87.96 (a)
Fcho1 16
Fcho1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FCHO1 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FCHO1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FCHO1 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26150 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fcho1 35
  • 57.44 (n)
  • 54.34 (a)
zebrafish
(Danio rerio)
Actinopterygii fcho1 35
  • 60.31 (n)
  • 56.55 (a)
FCHO1 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8176 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fcho-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for FCHO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FCHO1 Gene

ENSEMBL:
Gene Tree for FCHO1 (if available)
TreeFam:
Gene Tree for FCHO1 (if available)

Paralogs for FCHO1 Gene

Paralogs for FCHO1 Gene

genes like me logo Genes that share paralogs with FCHO1: view

Variants for FCHO1 Gene

Sequence variations from dbSNP and Humsavar for FCHO1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs123389 -- 17,785,979(+) aattt(A/T)aaaaa intron-variant
rs123390 -- 17,786,016(+) ACTTA(C/T)AGGAC intron-variant
rs265553 -- 17,787,908(+) GCCCC(A/G)GGGTG intron-variant
rs265554 -- 17,787,385(+) cagcc(A/T)gggca intron-variant
rs265555 -- 17,785,065(+) GTGAT(A/G)TTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCHO1 Gene

Variant ID Type Subtype PubMed ID
dgv50n68 CNV Loss 17160897
nsv911208 CNV Loss 21882294
nsv911209 CNV Loss 21882294
dgv3764n71 CNV Loss 21882294
nsv911214 CNV Loss 21882294
dgv3765n71 CNV Loss 21882294
nsv911218 CNV Gain 21882294
nsv911219 CNV Loss 21882294

Relevant External Links for FCHO1 Gene

HapMap Linkage Disequilibrium report
FCHO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCHO1 Gene

Disorders for FCHO1 Gene

Relevant External Links for FCHO1

Genetic Association Database (GAD)
FCHO1
genes like me logo Genes that share disorders with FCHO1: view

No data available for UniProtKB/Swiss-Prot for FCHO1 Gene

Publications for FCHO1 Gene

  1. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation. (PMID: 17617719) Sakaushi S. … Sugimoto K. (Biosci. Biotechnol. Biochem. 2007) 3 4
  5. FCHo proteins are nucleators of clathrin-mediated endocytosis. (PMID: 20448150) Henne W.M. … McMahon H.T. (Science 2010) 3 4

Products for FCHO1 Gene

  • antibodies-online peptides for FCHO1
  • antibodies-online antibodies for FCHO1
  • antibodies-online kits for FCHO1

Sources for FCHO1 Gene

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