Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FCHO1 Gene

protein-coding   GIFtS: 51
GCID: GC19P017956

FCH Domain Only 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
FCH Domain Only 11 2
FCH Domain Only Protein 12
KIAA02903

External Ids:    HGNC: 290021   Entrez Gene: 231492   Ensembl: ENSG000001304757   OMIM: 6134375   UniProtKB: O145263   

Export aliases for FCHO1 gene to outside databases

Previous GC identifers: GC19P017723 GC19P017599 GC19P017862 GC19P017423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for FCHO1 Gene:
FCHO1 (FCH domain only 1) is a protein-coding gene. GO annotations related to this gene include AP-2 adaptor complex binding. An important paralog of this gene is FCHO2.

UniProtKB/Swiss-Prot: FCHO1_HUMAN, O14526
Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending
activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May
regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCHO1 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   c-Ets-1   RORalpha2   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCHO1 promoter sequence
   Search Chromatin IP Primers for FCHO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCHO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.12

FCHO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCHO1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017956:  view genomic region     (about GC identifiers)

Start:
17,858,527 bp from pter      End:
17,899,377 bp from pter
Size:
40,851 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FCHO1_HUMAN, O14526 (See protein sequence)
Recommended Name: FCH domain only protein 1  
Size: 889 amino acids; 96861 Da
Subunit: May oligomerize and form homotetramer (By similarity). Interacts with AP2A2 and AP2B1; 2 subunits of the
adaptor protein complex AP-2. Interacts with DAB2. Interacts with clathrin (CLTC or CLTCL1). Interacts with
EPS15, EPS15R and ITSN1. Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to
clathrin-mediated endocytosis
Sequence caution: Sequence=BAA22959.1; Type=Erroneous initiation;
Secondary accessions: A6NHE6 A8K5U5 B4E120 Q05C93 Q8IW22
Alternative splicing: 3 isoforms:  O14526-1   O14526-2   O14526-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCHO1: NX_O14526

Explore proteomics data for FCHO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FCHO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001154829.1  NP_001154830.1  NP_001154831.1  NP_055937.1  

    ENSEMBL proteins: 
     ENSP00000473001   ENSP00000470493   ENSP00000469075   ENSP00000470511   ENSP00000469711  
     ENSP00000470730   ENSP00000471003   ENSP00000469458   ENSP00000470495   ENSP00000470731  
     ENSP00000470068   ENSP00000469425   ENSP00000471563   ENSP00000471935   ENSP00000469511  
     ENSP00000473169   ENSP00000472668   ENSP00000473173   ENSP00000471450   ENSP00000472623  
     ENSP00000469967   ENSP00000472417   ENSP00000470578   ENSP00000470568   ENSP00000252771  
     ENSP00000373785   ENSP00000437978  

    FCHO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FCHO1
    GenScript Custom Purified and Recombinant Proteins Services for FCHO1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FCHO1

     
    Search eBioscience for Proteins for FCHO1 

     
    Search antibodies-online for proteins for FCHO1 

     
    antibodies-online peptides for FCHO1

    FCHO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FCHO1
    Novus Biologicals FCHO1 Antibodies
    Abcam antibodies for FCHO1
    Cloud-Clone Corp. Antibodies for FCHO1
    ThermoFisher Antibody for FCHO1
    antibodies-online antibodies for FCHO1 (20 products) 

    FCHO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FCHO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FCHO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FCHO1
    Cloud-Clone Corp. CLIAs for FCHO1
    Search eBioscience for ELISAs for FCHO1 
    antibodies-online kits for FCHO1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR001060 FCH_dom
     IPR018808 Muniscin_C
     IPR028565 MHD

    Graphical View of Domain Structure for InterPro Entry O14526

    ProtoNet protein and cluster: O14526

    1 Blocks protein domain: IPB001060 Cdc15/Fes/CIP4

    UniProtKB/Swiss-Prot: FCHO1_HUMAN, O14526
    Similarity: Belongs to the FCHO family
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 MHD (mu homology) domain


    Find genes that share domains with FCHO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCHO1_HUMAN, O14526
    Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending
    activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May
    regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19713939
    GO:0035612AP-2 adaptor complex binding IDA--
         
    Find genes that share ontologies with FCHO1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FCHO1:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FCHO1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FCHO1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FCHO1:
    hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidFCHO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FCHO1
    Predesigned siRNA for gene silencing in human, mouse, rat FCHO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCHO1

    Clone
    Products:
         
    OriGene clones in human, mouse for FCHO1 (see all 23)
    OriGene ORF clones in mouse, rat for FCHO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): FCHO1 (NM_015122)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCHO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHO1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCHO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for FCHO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12028) for FCHO1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FCHO1_HUMAN, O14526: Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (Probable).
    Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the
    one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically
    associate with Golgi/TGN membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0005905coated pit IDA--
    GO:0030136NOT colocalizes with clathrin-coated vesicle IDA--

    Find genes that share ontologies with FCHO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCHO1
    Interactions:

        Search GeneGlobe Interaction Network for FCHO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FCHO1 (O145261, 2, 3 ENSP000002527714) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    ZBTB16Q055163, ENSP000003381574I2D: score=4 STRING: ENSP00000338157
    DVL2O146413I2D: score=1 
    TGFBR1P368973I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048268clathrin coat assembly IMP--
    GO:0072583clathrin-mediated endocytosis IMP--

    Find genes that share ontologies with FCHO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCHO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FCHO1 gene (4 alternative transcripts): 
    NM_001161357.1  NM_001161358.1  NM_001161359.1  NM_015122.2  

    Unigene Cluster for FCHO1:

    FCH domain only 1
    Hs.96485  [show with all ESTs]
    Unigene Representative Sequence: NM_001161357
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 38):
    ENST00000594202 ENST00000600676 ENST00000600209 ENST00000596309 ENST00000598539
    ENST00000597474 ENST00000593385 ENST00000600201 ENST00000598067 ENST00000599236
    ENST00000593833 ENST00000601247 ENST00000596536 ENST00000593870 ENST00000598086
    ENST00000598932 ENST00000595023 ENST00000594068
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FCHO1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FCHO1:
    hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidFCHO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FCHO1
    Predesigned siRNA for gene silencing in human, mouse, rat FCHO1
    Clone
    Products:
         
    OriGene clones in human, mouse for FCHO1 (see all 23)
    OriGene ORF clones in mouse, rat for FCHO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): FCHO1 (NM_015122)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCHO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHO1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FCHO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCHO1
      QuantiTect SYBR Green Assays in human, mouse, rat FCHO1
      QuantiFast Probe-based Assays in human, mouse, rat FCHO1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12028) for FCHO1 

    Additional mRNA sequence: 

    AB006628.1 AK291410.1 AK303623.1 AK309403.1 AK316458.1 BC028021.1 BC041130.1 

    13 DOTS entries:

    DT.100036023  DT.312545  DT.100766230  DT.100774514  DT.95347586  DT.92422992  DT.121431764  DT.121431840 
    DT.121431928  DT.95351460  DT.100774513  DT.121431826  DT.121432213 

    Selected AceView cDNA sequences (see all 96):

    BQ064888 CR620485 BM920233 AA574335 BX443350 CR625849 BM669314 BC028021 
    BU848765 BM473454 CR603801 BU159767 CR597235 BU187271 AA400186 CB117945 
    BM457736 BM767463 BM472444 BM193912 BE271942 BM477094 BI908379 AA400344 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FCHO1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:              -           -           -     -           -                                                                       -     -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:        -                       -     -                                                               
    SP2:                                -     -                                                               
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                  -                                                   


    ECgene alternative splicing isoforms for FCHO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FCHO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FCHO1 Expression
    About this image


    FCHO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Eye (Sensory Organs)
             Retina
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    FCHO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCHO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.96485
        Custom PCR Arrays for FCHO1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FCHO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCHO1
    QuantiTect SYBR Green Assays in human, mouse, rat FCHO1
    QuantiFast Probe-based Assays in human, mouse, rat FCHO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FCHO1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcho11 , 5 FCH domain only 11, 5 82.87(n)1
    87.96(a)1
      8 (34.43 cM)5
    740151  NM_028715.31  NP_082991.31 
     717083945 
    chicken
    (Gallus gallus)
    Aves FCHO16
    FCH domain only 1
    55(a)
    1 ↔ 1
    Z(24789435-24869928)
    lizard
    (Anolis carolinensis)
    Reptilia FCHO16
    FCH domain only 1
    62(a)
    1 ↔ 1
    AAWZ02040336(21-6884)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.261502 Xenopus laevis transcribed sequence with weak similarity more 73.04(n)    CD360181.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fcho11 FCH domain only 1 60.31(n)
    56.55(a)
      100913078  XM_005166937.1  XP_005166994.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81766
    --
    23(a)
    1 → many
    3R(5341758-5352964)
    worm
    (Caenorhabditis elegans)
    Secernentea fcho-16
    Protein F56D12.6, isoform a (F56D12.6) mRNA, compl...
    20(a)
    1 → many
    II(1310535-1320438) WBGene00018974


    ENSEMBL Gene Tree for FCHO1 (if available)
    TreeFam Gene Tree for FCHO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FCHO1 gene
    FCHO22  SGIP12  
    3 SIMAP similar genes for FCHO1 using alignment to 19 protein entries:     FCHO1_HUMAN (see all proteins):
    FCHO2    SGIP1    PACSIN3

    Find genes that share paralogs with FCHO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FCHO1 (see all 1137)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs610484041,2
    C--17453455(+) AAAAA-/A/AAA 
    A
    /AAAAAA
    GCAAA
    4 -- int11NA 2
    rs588075811,2
    --17856535(+) ATTGCC/TTGAGC 2 -- us2k10--------
    rs1136695601,2
    F--17856554(+) CAGAGG/CTTGCA 2 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1836169551,2
    --17856640(+) AATAAC/TAATAA 2 -- us2k10--------
    rs1904338901,2
    --17856661(+) CCGGGG/TGCAGT 2 -- us2k10--------
    rs283734751,2
    --17856791(+) TTAGCC/TGGGTG 2 -- us2k10--------
    rs287762941,2
    --17856803(+) GGTGGC/TGGGTG 2 -- us2k10--------
    rs2005549861,2
    C--17856928(+) TCTCA-/AAT/AAT
    AATAATAAT
    AATAA
    4 -- cds10--------
    rs1932219921,2
    --17856992(+) CCCAGC/GACTTT 2 -- us2k10--------
    rs1484984491,2
    --17857071(+) CCTGTC/TTCTAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCHO1 (17858527 - 17899377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FCHO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3764n71CNV Loss21882294
    dgv50n68CNV Loss17160897
    nsv911208CNV Loss21882294
    nsv911214CNV Loss21882294
    nsv911219CNV Loss21882294
    nsv911209CNV Loss21882294
    dgv3765n71CNV Loss21882294
    nsv911218CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCHO1
    DNA2.0 Custom Variant and Variant Library Synthesis for FCHO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613437    OMIM disorders: --


    Find genes that share disorders with FCHO1           About GenesLikeMe

    Genetic Association Database (GAD): FCHO1

    Export disorders for FCHO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FCHO1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FCHO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. (PubMed id 22484487)1, 2 Umasankar P.K.... Traub L.M. (Nat. Cell Biol. 2012)
    2. FCHo proteins are nucleators of clathrin-mediated endocytosis. (PubMed id 20448150)1, 2 Henne W.M.... McMahon H.T. (Science 2010)
    3. Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation. (PubMed id 17617719)1, 2 Sakaushi S....Sugimoto K. (Biosci. Biotechnol. Biochem. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (DNA Res. 1997)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. (PubMed id 19713939)1 Reider A....Wendland B. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23149 HGNC: 29002 AceView: FCHO1 Ensembl:ENSG00000130475 euGenes: HUgn23149
    ECgene: FCHO1 H-InvDB: FCHO1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0290

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FCHO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCHO1 gene:
    Search GeneIP for patents involving FCHO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FCHO1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FCHO1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FCHO1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FCHO1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCHO1   OriGene Custom Protein Services for FCHO1  

     
     
     Block miRNA regulation of human, mouse, rat FCHO1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FCHO1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCHO1 Predesigned siRNA for gene silencing in human, mouse, rat FCHO1
     QuantiFast Probe-based Assays in human, mouse, rat FCHO1 QuantiTect SYBR Green Assays in human, mouse, rat FCHO1
     Custom PCR Arrays for FCHO1 Search Chromatin IP Primers for FCHO1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCHO1  Search GeneGlobe Interaction Network for FCHO1
     Regulatory tfbs in FCHO1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FCHO1 GenScript cDNA clones with any tag delivered in your preferred vector for FCHO1
     GenScript Custom Assay Services for FCHO1 GenScript Custom overexpressing Cell Line Services for FCHO1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FCHO1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FCHO1 antibodies
     Antibodies for FCHO1
     See all of Abcam's Antibodies, Kits and Proteins for FCHO1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FCHO1
     Antibodies for FCHO1
     ELISAs for FCHO1
     CLIAs for FCHO1



     Browse ESI BIO Cell Lines and PureStem Progenitors for FCHO1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCHO1
     SwitchGear 3'UTR luciferase reporter plasmids for FCHO1
     SwitchGear Promoter luciferase reporter plasmids for FCHO1
     ThermoFisher Antibody for FCHO1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCHO1
     Browse compounds at ApexBio
     Search Addgene for plasmids for FCHO1
      Search eBioscience for proteins for FCHO1
      Search eBioscience for elisas for FCHO1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FCHO1
     antibodies-online antibodies for FCHO1 (20 products)
     antibodies-online kits for FCHO1 (4 products)
     antibodies-online peptides for FCHO1
      Search antibodies-online for proteins for FCHO1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FCHO1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4