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FCGRT Gene

protein-coding   GIFtS: 60
GCID: GC19P050047

Fc Fragment Of IgG, Receptor, Transporter, Alpha

  See FCGRT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fc Fragment Of IgG, Receptor, Transporter, Alpha1 2     IgG Receptor FcRn Large Subunit P512
Neonatal Fc Receptor2 3     Immunoglobulin Receptor, Intestinal, Heavy Chain2
FCRN2 3     Major Histocompatibility Complex Class I-Like Fc Receptor2
IgG Fc Fragment Receptor Transporter Alpha Chain2 3     Neonatal Fc-Receptor For Ig2
alpha-chain2     FcRn3
FcRn Alpha Chain2     

External Ids:    HGNC: 36211   Entrez Gene: 22172   Ensembl: ENSG000001048707   OMIM: 6014375   UniProtKB: P558993   
ORGUL members:         

Export aliases for FCGRT gene to outside databases

Previous GC identifers: GC19P050674 GC19P050384 GC19P054691 GC19P054707 GC19P054708 GC19P050015 GC19P046393 GC19P050028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCGRT Gene:
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers
immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to
protect the antibody from degradation. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Apr 2009)

GeneCards Summary for FCGRT Gene:
FCGRT (Fc fragment of IgG, receptor, transporter, alpha) is a protein-coding gene. Diseases associated with FCGRT include hypoproteinemia, hypercatabolic, and persistent fetal circulation syndrome. GO annotations related to this gene include antigen binding and beta-2-microglobulin binding. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: FCGRN_HUMAN, P55899
Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk.
Possible role in transfer of immunoglobulin G from mother to fetus

Gene Wiki entry for FCGRT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGRT gene promoter:
         NF-1   NF-1/L   STAT3   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGRT promoter sequence
   Search Chromatin IP Primers for FCGRT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

FCGRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGRT gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050047:  view genomic region     (about GC identifiers)

Start:
50,010,073 bp from pter      End:
50,029,685 bp from pter
Size:
19,613 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FCGRN_HUMAN, P55899 (See protein sequence)
Recommended Name: IgG receptor FcRn large subunit p51 precursor  
Size: 365 amino acids; 39743 Da
Subunit: FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms
an MHC class I-like heterodimer (By similarity)
4 PDB 3D structures from and Proteopedia for FCGRT:
1EXU (3D)        3M17 (3D)        3M1B (3D)        4K71 (3D)    
Secondary accessions: Q5HYM5 Q9HBV7 Q9NZ19

Explore the universe of human proteins at neXtProt for FCGRT: NX_P55899

Explore proteomics data for FCGRT at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn125
  • Modification sites at PhosphoSitePlus

  • See FCGRT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129491.1  NP_004098.1  

    ENSEMBL proteins: 
     ENSP00000221466   ENSP00000472350   ENSP00000472794   ENSP00000469968   ENSP00000410798  
     ENSP00000469933   ENSP00000471300   ENSP00000471118   ENSP00000472604   ENSP00000469949  
     ENSP00000472256   ENSP00000471232  

    FCGRT Human Recombinant Protein Products:

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    Novus Biologicals FCGRT Protein
    Novus Biologicals FCGRT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FCGRT 

    FCGRT Antibody Products:

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    Search ThermoFisher Antibodies for FCGRT
    LSBio Antibodies in human, mouse, rat for FCGRT

    FCGRT Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FCGRT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P55899

    ProtoNet protein and cluster: P55899

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: FCGRN_HUMAN, P55899
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with FCGRT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGRN_HUMAN, P55899
    Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk.
    Possible role in transfer of immunoglobulin G from mother to fetus

         Genatlas biochemistry entry for FCGRT:
    MHC,class I-like FC receptor,FCGRT

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IBA--
    GO:0005515protein binding ----
    GO:0019770IgG receptor activity IBA--
    GO:0019864IgG binding IDA7964511
    GO:0030881beta-2-microglobulin binding IBA--
         
    Find genes that share ontologies with FCGRT           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fcgrt):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with FCGRT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fcgrttm1Dcr for FCGRT

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCGRT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCGRT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCGRT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCGRT

    miRNA
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    miRTarBase miRNAs that target FCGRT:
    hsa-mir-335-5p (MIRT017375)

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    5 qRT-PCR Assays for microRNAs that regulate FCGRT:
    hsa-miR-516b hsa-miR-3919 hsa-miR-1827 hsa-miR-24 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidFCGRT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FCGRT

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): FCGRT (NM_001136019)
    Sino Biological Human cDNA Clone for FCGRT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGRT

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGRT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCGRN_HUMAN, P55899: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome2
    extracellular2
    lysosome2
    cytosol1
    endoplasmic reticulum1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IBA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FCGRT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCGRT
    Interactions:

        GeneGlobe Interaction Network for FCGRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FCGRT (P558992, 3 ENSP000002214664) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617692, 3, ENSP000003408584MINT-24843 I2D: score=6 STRING: ENSP00000340858
    ALBP027683, ENSP000002958974I2D: score=2 STRING: ENSP00000295897
    CA6P232803, ENSP000003666624I2D: score=1 STRING: ENSP00000366662
    ELANEP082463I2D: score=1 
    PSAPENSP000003783944STRING: ENSP00000378394
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002416IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS7964511
    GO:0006955immune response IEA--
    GO:0019882antigen processing and presentation IBA--
    GO:0038094Fc-gamma receptor signaling pathway IBA--

    Find genes that share ontologies with FCGRT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGRT (FCGRN)

    5 Novoseek inferred chemical compound relationships for FCGRT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ivig 35.7 8 19630809 (1), 20507387 (1), 15866704 (1), 16284651 (1)
    histidine 13.1 6 9493268 (2), 7889418 (1), 17048273 (1), 7578107 (1)
    lipid 0 1 9523114 (1)
    iron 0 3 11935295 (1), 9780177 (1), 9523114 (1)
    methionine 0 4 19165723 (2), 19269032 (1)



    Find genes that share compounds with FCGRT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCGRT gene (2 alternative transcripts): 
    NM_001136019.2  NM_004107.4  

    Unigene Cluster for FCGRT:

    Fc fragment of IgG, receptor, transporter, alpha
    Hs.111903  [show with all ESTs]
    Unigene Representative Sequence: NM_001136019
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000596147 ENST00000221466(uc002poe.2) ENST00000598491 ENST00000599701
    ENST00000598927 ENST00000426395(uc002pog.2 uc002poi.2) ENST00000595677
    ENST00000600273 ENST00000595881 ENST00000594823 ENST00000599988 ENST00000596975
    ENST00000598936 ENST00000452439(uc002pof.2 uc010yax.2 uc002poh.2)
    ENST00000593431 ENST00000598319 ENST00000598949 ENST00000593381
    miRNA
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    Block miRNA regulation of human, mouse, rat FCGRT using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate FCGRT:
    hsa-miR-516b hsa-miR-3919 hsa-miR-1827 hsa-miR-24 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidFCGRT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FCGRT
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FCGRT (NM_001136019)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGRT
    Primer
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    OriGene qPCR primer pairs and template standards for FCGRT
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCGRT
      QuantiTect SYBR Green Assays in human, mouse, rat FCGRT
      QuantiFast Probe-based Assays in human, mouse, rat FCGRT

    Additional mRNA sequence: 

    AK075510.1 AK075532.1 AK299124.1 BC008734.2 BC091487.1 BT006828.1 BX647163.1 U12255.1 

    Selected DOTS entries (see all 38):

    DT.87010493  DT.91765079  DT.91906150  DT.100888139  DT.87018106  DT.101985215  DT.91964308  DT.100833934 
    DT.99973456  DT.100888115  DT.100030336  DT.100888141  DT.91765054  DT.95297798  DT.100888125  DT.110632 
    DT.91765071  DT.100888137  DT.121477292  DT.87009659  DT.95256835  DT.100030335  DT.100888118  DT.100888134 

    Selected AceView cDNA sequences (see all 31):

    CR617299 CR626832 CR606505 CR604068 CR591612 CR599170 BC008734 BC020421 
    CR622938 CR616651 CR614236 AK075510 CR609370 CR597151 CR599433 BX647163 
    CR596741 CR622853 CR596606 NM_004107 CR626812 CR622710 CR625984 CR593355 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FCGRT (see all 19)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^
    SP1:                          -     -     -     -                                                                                   -     -     -     -     -   
    SP2:                          -     -     -     -                                                                                         -     -               
    SP3:                                                                                                                                -     -     -     -     -   
    SP4:                    -     -     -     -     -                                                                                                               
    SP5:                                      -     -                                                                                                               

    ExUns: 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b
    SP1:  -                       -     -                     
    SP2:                                                      
    SP3:  -                       -     -                     
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for FCGRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCGRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGAGACC
    FCGRT Expression
    About this image


    FCGRT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Blood (Hematopoietic System)
             Common Dendritic Cell Precursors Hematopoietic Bone Marrow
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    FCGRT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGRT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111903
        Custom PCR Arrays for FCGRT
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FCGRT gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgrt1 , 5 Fc receptor, IgG, alpha chain transporter1, 5 70.09(n)1
    66.94(a)1
      7 (29.12 cM)5
    141321  NM_010189.31  NP_034319.21 
     450929935 
    chicken
    (Gallus gallus)
    Aves BFIV216
    --
    (see all 17)
    Uncharacterized protein
    (see all 17)
    26(a)
    25(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    16(59616-62099)
    JH375197.1(5805-7031)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 20)
    Uncharacterized protein
    (see all 20)
    29(a)
    29(a)
    (see all 20)
    many ↔ many
    many ↔ many
    (see all 20)
    AAWZ02040156(3915-5955)
    AAWZ02039289(774-2823)


    ENSEMBL Gene Tree for FCGRT (if available)
    TreeFam Gene Tree for FCGRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCGRT gene
    HLA-F2  MR12  HFE2  HLA-B2  HLA-E2  HLA-C2  HLA-A2  HLA-G2  
    AZGP12  
    Selected SIMAP similar genes for FCGRT using alignment to 10 protein entries:     FCGRN_HUMAN (see all proteins) (see all similar genes):
    HLA-ABC    EA2.1    HLA-Cw2    HLA-DRB1    HLA-E    HFE
    HLA B    HLA C*    HLA-A*0201V3    HLA-DQB    HLA-DRB4    HLA-G2.2
    HLA-G    MICA    HLA-A*03    HLA-A*24    HLA-Cw*15P    HLA-B18

    Find genes that share paralogs with FCGRT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCGRT (see all 375)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880080591,2
    --46390776(+) AGATAA/CGCTCT 1 -- us2k10--------
    rs341656791,2
    C,F--46390881(+) TGAGAT/CTTATG 1 -- us2k13Minor allele frequency- C:0.10NA 124
    rs1925791381,2
    --46390925(+) CCCTTC/TCTGAA 1 -- us2k10--------
    rs1423400681,2
    --46390937(+) TGAGGC/GAGGCT 1 -- us2k10--------
    rs72462001,2
    C--50013537(+) ttggaA/Cggctg 1 -- us2k10--------
    rs1390395591,2
    --50013540(+) GAAGGC/TTGAGG 1 -- us2k10--------
    rs1489999361,2
    --50013578(+) AGGCCA/GTCCTG 1 -- us2k10--------
    rs1895747551,2
    --50013633(+) AACCGA/GGTGTG 1 -- us2k10--------
    rs1438275181,2
    C--50013686(+) AGGAGA/GATCGC 1 -- us2k10--------
    rs1924402921,2
    --50013699(+) GAACCC/TGGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCGRT (50010073 - 50029685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FCGRT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833862CNV Loss17160897
    nsv912262CNV Loss21882294
    nsv912264CNV Loss21882294
    nsv833863CNV Loss17160897
    nsv912261CNV Loss21882294
    nsv912265CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): FCGRT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCGRT
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGRT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601437    OMIM disorders: --

    3 diseases for FCGRT:    
    About MalaCards
    hypoproteinemia, hypercatabolic    persistent fetal circulation syndrome    epidermolysis bullosa acquisita

    1 disease from the University of Copenhagen DISEASES database for FCGRT:
    Persistent fetal circulation syndrome

    Find genes that share disorders with FCGRT           About GenesLikeMe

    5 Novoseek inferred disease relationships for FCGRT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypoproteinemia, hypercatabolic 89.2 4 17046328 (1), 16549777 (1)
    igg deficiency 71.7 2 17046328 (1)
    autoimmune diseases 26.8 11 16284651 (1), 19772792 (1), 20092334 (1), 20432181 (1) (see all 5)
    hemochromatosis 20.6 2 11935295 (1), 9523114 (1)
    tumors 2.54 6 16818514 (2), 20354184 (1), 16546710 (1)

    Genetic Association Database (GAD): FCGRT
    Human Genome Epidemiology (HuGE) Navigator: FCGRT (6 documents)

    Export disorders for FCGRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCGRT gene, integrated from 10 sources (see all 162):
    (articles sorted by number of sources associating them with FCGRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. (PubMed id 7964511)1, 2, 3 Story C.M.... Simister N.E. (J. Exp. Med. 1994)
    2. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. (PubMed id 10933786)1, 2, 9 West A.P. Jr. and Bjorkman P.J. (Biochemistry 2000)
    3. Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients. (PubMed id 19772792)1, 4, 9 Zhou X.J....Zhang H. (Clin. Exp. Rheumatol. 2009)
    4. Cloning and analysis of the gene encoding the human neonatal Fc receptor. (PubMed id 10998088)1, 2, 9 Mikulska J.E.... Simister N.E. (Eur. J. Immunogenet. 2000)
    5. The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. (PubMed id 8646894)1, 3, 9 Kandil E....Miyosi O. (Cytogenet. Cell Genet. 1996)
    6. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues. (PubMed id 18637944)1, 9 Andersen J.T....Sandlie I. (FEBS J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2217 HGNC: 3621 AceView: FCGRT Ensembl:ENSG00000104870 euGenes: HUgn2217
    ECgene: FCGRT H-InvDB: FCGRT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCGRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCGRT gene:
    Search GeneIP for patents involving FCGRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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