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Aliases for FCGRT Gene

Aliases for FCGRT Gene

  • Fc Fragment Of IgG, Receptor, Transporter, Alpha 2 3
  • IgG Fc Fragment Receptor Transporter Alpha Chain 3 4
  • Neonatal Fc Receptor 3 4
  • FCRN 3 4
  • Major Histocompatibility Complex Class I-Like Fc Receptor 3
  • Immunoglobulin Receptor, Intestinal, Heavy Chain 3
  • IgG Receptor FcRn Large Subunit P51 3
  • Neonatal Fc-Receptor For Ig 3
  • FcRn Alpha Chain 3
  • Alpha-Chain 3

External Ids for FCGRT Gene

Previous GeneCards Identifiers for FCGRT Gene

  • GC19P050674
  • GC19P050384
  • GC19P054691
  • GC19P054707
  • GC19P054708
  • GC19P050015
  • GC19P046393
  • GC19P050028
  • GC19P050047

Summaries for FCGRT Gene

Entrez Gene Summary for FCGRT Gene

  • This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCGRT Gene

FCGRT (Fc Fragment Of IgG, Receptor, Transporter, Alpha) is a Protein Coding gene. Diseases associated with FCGRT include persistent fetal circulation syndrome and hypoproteinemia, hypercatabolic. GO annotations related to this gene include antigen binding and beta-2-microglobulin binding. An important paralog of this gene is MR1.

UniProtKB/Swiss-Prot for FCGRT Gene

  • Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus

Gene Wiki entry for FCGRT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGRT Gene

Genomics for FCGRT Gene

Regulatory Elements for FCGRT Gene

Genomic Location for FCGRT Gene

Start:
49,506,816 bp from pter
End:
49,526,428 bp from pter
Size:
19,613 bases
Orientation:
Plus strand

Genomic View for FCGRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGRT Gene

Proteins for FCGRT Gene

  • Protein details for FCGRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55899-FCGRN_HUMAN
    Recommended name:
    IgG receptor FcRn large subunit p51
    Protein Accession:
    P55899
    Secondary Accessions:
    • Q5HYM5
    • Q9HBV7
    • Q9NZ19

    Protein attributes for FCGRT Gene

    Size:
    365 amino acids
    Molecular mass:
    39743 Da
    Quaternary structure:
    • FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity).

    Three dimensional structures from OCA and Proteopedia for FCGRT Gene

neXtProt entry for FCGRT Gene

Proteomics data for FCGRT Gene at MOPED

Post-translational modifications for FCGRT Gene

  • Glycosylation at Asn125
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FCGRT Gene

Domains for FCGRT Gene

Gene Families for FCGRT Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing

Suggested Antigen Peptide Sequences for FCGRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55899

UniProtKB/Swiss-Prot:

FCGRN_HUMAN :
  • P55899
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with FCGRT: view

Function for FCGRT Gene

Molecular function for FCGRT Gene

GENATLAS Biochemistry: MHC,class I-like FC receptor,FCGRT
UniProtKB/Swiss-Prot Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus

Gene Ontology (GO) - Molecular Function for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0005515 protein binding --
GO:0019770 IgG receptor activity IBA --
GO:0019864 IgG binding IDA 7964511
GO:0030881 beta-2-microglobulin binding IBA --
genes like me logo Genes that share ontologies with FCGRT: view
genes like me logo Genes that share phenotypes with FCGRT: view

Animal Models for FCGRT Gene

MGI Knock Outs for FCGRT:

Animal Model Products

CRISPR Products

miRNA for FCGRT Gene

miRTarBase miRNAs that target FCGRT

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FCGRT Gene

Localization for FCGRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGRT Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGRT Gene COMPARTMENTS Subcellular localization image for FCGRT gene
Compartment Confidence
plasma membrane 5
endosome 2
extracellular 2
lysosome 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCGRT: view

Pathways for FCGRT Gene

SuperPathways for FCGRT Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS 7964511
GO:0006955 immune response IEA --
GO:0019882 antigen processing and presentation IBA --
GO:0038094 Fc-gamma receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with FCGRT: view

No data available for Pathways by source for FCGRT Gene

Compounds for FCGRT Gene

(5) Novoseek inferred chemical compound relationships for FCGRT Gene

Compound -log(P) Hits PubMed IDs
ivig 35.7 4
histidine 13.1 5
lipid 0 1
iron 0 3
methionine 0 3
genes like me logo Genes that share compounds with FCGRT: view

Transcripts for FCGRT Gene

Unigene Clusters for FCGRT Gene

Fc fragment of IgG, receptor, transporter, alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGRT

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGRT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - - - - -
SP13: - - - - -
SP14: -
SP15: - - - - -
SP16: - - - - -
SP17:
SP18: - - - - - - - - - - - - - - - -
SP19: - - - - -

ExUns: 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b
SP1: - - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: - -
SP14:
SP15:
SP16: - - - - - - -
SP17:
SP18: - - - - - -
SP19: -

Relevant External Links for FCGRT Gene

GeneLoc Exon Structure for
FCGRT
ECgene alternative splicing isoforms for
FCGRT

Expression for FCGRT Gene

mRNA expression in normal human tissues for FCGRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGRT Gene

This gene is overexpressed in Whole Blood (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FCGRT Gene

SOURCE GeneReport for Unigene cluster for FCGRT Gene Hs.111903

genes like me logo Genes that share expressions with FCGRT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FCGRT Gene

Orthologs for FCGRT Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCGRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGRT 35
  • 99.42 (n)
  • 99.71 (a)
FCGRT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCGRT 35
  • 81.21 (n)
  • 77.34 (a)
FCGRT 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCGRT 35
  • 84.42 (n)
  • 83.29 (a)
FCGRT 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcgrt 35
  • 70.09 (n)
  • 66.94 (a)
Fcgrt 16
Fcgrt 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCGRT 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fcgrt 35
  • 69.88 (n)
  • 66.08 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 25 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
BF1 36
  • 24 (a)
ManyToMany
BFIV21 36
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for FCGRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGRT Gene

ENSEMBL:
Gene Tree for FCGRT (if available)
TreeFam:
Gene Tree for FCGRT (if available)

Paralogs for FCGRT Gene

Paralogs for FCGRT Gene

genes like me logo Genes that share paralogs with FCGRT: view

Variants for FCGRT Gene

Sequence variations from dbSNP and Humsavar for FCGRT Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1132990 -- 49,524,906(+) ACCTC(A/G)CGCCT intron-variant
rs1142904 -- 49,517,498(+) agaaa(G/T)aagga intron-variant
rs1997594 -- 49,515,533(+) acctc(A/C)gcctc intron-variant
rs2335534 -- 49,511,720(+) gcagc(A/G)gctgt upstream-variant-2KB
rs2878342 -- 49,514,467(-) TTTCC(A/G)CGGCC reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGRT Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv912264 CNV Loss 21882294
nsv833862 CNV Loss 17160897
nsv912265 CNV Loss 21882294
nsv833863 CNV Loss 17160897

Relevant External Links for FCGRT Gene

HapMap Linkage Disequilibrium report
FCGRT
Human Gene Mutation Database (HGMD)
FCGRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGRT Gene

Disorders for FCGRT Gene

(1) University of Copenhagen DISEASES for FCGRT Gene

(5) Novoseek inferred disease relationships for FCGRT Gene

Disease -log(P) Hits PubMed IDs
hypoproteinemia, hypercatabolic 89.2 2
igg deficiency 71.7 1
autoimmune diseases 26.8 5
hemochromatosis 20.6 2
tumors 2.54 4

Relevant External Links for FCGRT

Genetic Association Database (GAD)
FCGRT
Human Genome Epidemiology (HuGE) Navigator
FCGRT
genes like me logo Genes that share disorders with FCGRT: view

No data available for UniProtKB/Swiss-Prot for FCGRT Gene

Publications for FCGRT Gene

  1. The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. (PMID: 8646894) Kandil E. … Miyosi O. (Cytogenet. Cell Genet. 1996) 2 3 23
  2. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. (PMID: 10933786) West A.P. Jr. … Bjorkman P.J. (Biochemistry 2000) 3 4 23
  3. Cloning and analysis of the gene encoding the human neonatal Fc receptor. (PMID: 10998088) Mikulska J.E. … Simister N.E. (Eur. J. Immunogenet. 2000) 3 4 23
  4. Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients. (PMID: 19772792) Zhou X.J. … Zhang H. (Clin. Exp. Rheumatol. 2009) 3 23 48
  5. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. (PMID: 7964511) Story C.M. … Simister N.E. (J. Exp. Med. 1994) 2 3 4

Products for FCGRT Gene

Sources for FCGRT Gene

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