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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCGRT Gene

protein-coding   GIFtS: 56
GCID: GC19P050015

Fc fragment of IgG, receptor, transporter, alpha

 Explore 16 diseases affiliated with
FCGRT via our new
 Human Malady Compendium 
Biological research products
for FCGRT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fc Fragment Of IgG, Receptor, Transporter, Alpha1 2     IgG Receptor FcRn Large Subunit P512
FCRN1 2 3     Immunoglobulin Receptor, Intestinal, Heavy Chain2
Alpha-Chain1     Major Histocompatibility Complex Class I-Like Fc Receptor2
Neonatal Fc Receptor2 3     Neonatal Fc-Receptor For Ig2
IgG Fc Fragment Receptor Transporter Alpha Chain2 3     FcRn3
FcRn Alpha Chain2     

External Ids:    HGNC: 36211   Entrez Gene: 22172   Ensembl: ENSG000001048707   OMIM: 6014375   UniProtKB: P558993   

Export aliases for FCGRT gene to outside databases

Previous GC identifers: GC19P050674 GC19P050384 GC19P054691 GC19P054707 GC19P054708 GC19P046393


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCGRT:
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers
immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to
protect the antibody from degradation. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: FCGRN_HUMAN, P55899
Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible
role in transfer of immunoglobulin G from mother to fetus

Gene Wiki entry for FCGRT


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCGRT gene promoter:
         NF-1   NF-1/L   STAT3   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGRT promoter sequence
   Search SABiosciences Chromatin IP Primers for FCGRT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

FCGRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGRT gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050015:  view genomic region     (about GC identifiers)

Start:
50,015,536 bp from pter      End:
50,029,685 bp from pter
Size:
14,150 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCGRN_HUMAN, P55899 (See protein sequence)
Recommended Name: IgG receptor FcRn large subunit p51 precursor  
Size: 365 amino acids; 39743 Da
Subunit: FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an
MHC class I-like heterodimer (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
3 PDB 3D structures from and Proteopedia for FCGRT:
1EXU (3D)        3M17 (3D)        3M1B (3D)    
Secondary accessions: Q5HYM5 Q9HBV7 Q9NZ19

Explore the universe of human proteins at neXtProt for FCGRT: NX_P55899

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55899

  • FCGRT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129491.1  NP_004098.1  

    ENSEMBL proteins: 
     ENSP00000221466   ENSP00000410798   ENSP00000402665  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): FCGRT
    OriGene Protein Over-expression Lysate (see all 2): FCGRT
    OriGene Custom Protein Services for FCGRT 
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    Novus Biologicals FCGRT Protein
    Novus Biologicals FCGRT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FCGRT

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0042612MHC class I protein complex IEA--


    FCGRT for ontologies           About GeneDecksing



    FCGRT Antibody Products: 
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    Search for Antibodies for FCGRT at Abcam  
    Uscn Antibodies for FCGRT
    Search ThermoFisher Antibodies for FCGRT

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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FCGRT


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FCGRT for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P55899

    ProtoNet protein and cluster: P55899

    1 Blocks protein family: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: FCGRN_HUMAN, P55899
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FCGRN_HUMAN, P55899
    Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible
    role in transfer of immunoglobulin G from mother to fetus

         Genatlas biochemistry entry for FCGRT:
    MHC,class I-like FC receptor,FCGRT

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FCGRT:
    hsa-miR-516b hsa-miR-3919 hsa-miR-1827 hsa-miR-24 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidFCGRT 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCGRT (see all 7)
    OriGene shRNA RFP: FCGRT
    OriGene siRNA: FCGRT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCGRT

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGRT 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGRT

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7964511
    GO:0019864IgG binding IEA--
    GO:0030881beta-2-microglobulin binding IEA--


    FCGRT for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fcgrttm1Dcr for FCGRT
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fcgrt):
     homeostasis/metabolism  immune system 

    FCGRT for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCGRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for FCGRT (P558992, 3 ENSP000002214664) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617692, 3, ENSP000003408584MINT-24843 I2D: score=6 STRING: ENSP00000340858
    ALBP027683, ENSP000002958974I2D: score=2 STRING: ENSP00000295897
    CA6P232803, ENSP000003666624I2D: score=1 STRING: ENSP00000366662
    ELANEP082463I2D: score=1 
    AZGP1ENSP000002924014STRING: ENSP00000292401
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0007565female pregnancy TAS7964511
    GO:0019882antigen processing and presentation IEA--


    FCGRT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCGRT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCGRT
    5 Novoseek chemical compound relationships for FCGRT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ivig 35.7 8 19630809 (1), 20507387 (1), 15866704 (1), 16284651 (1)
    histidine 13.1 6 9493268 (2), 7889418 (1), 17048273 (1), 7578107 (1)
    lipid 0 1 9523114 (1)
    iron 0 3 11935295 (1), 9780177 (1), 9523114 (1)
    methionine 0 4 19165723 (2), 19269032 (1)

    Search CenterWatch for drugs/clinical trials and news about FCGRT / FCGRN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCGRT gene (2 alternative transcripts): 
    NM_001136019.2  NM_004107.4  

    Unigene Cluster for FCGRT:

    Fc fragment of IgG, receptor, transporter, alpha
    Hs.111903  [show with all ESTs]
    Unigene Representative Sequence: NM_001136019
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221466(uc002poe.2) ENST00000426395(uc002pog.2 uc002poi.2)
    ENST00000452439(uc002pof.2 uc010yax.2 uc002poh.2)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FCGRT:
    hsa-miR-516b hsa-miR-3919 hsa-miR-1827 hsa-miR-24 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidFCGRT 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCGRT (see all 7)
    OriGene shRNA RFP: FCGRT
    OriGene siRNA: FCGRT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCGRT
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FCGRT (NM_001136019)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGRT 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGRT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGRT

    Additional cDNA sequence: 

    AK075510.1 AK075532.1 AK299124.1 BC008734.2 BC091487.1 BT006828.1 BX647163.1 U12255.1 

    24/38 DOTS entries (see all 38):

    DT.87010493  DT.91765079  DT.91906150  DT.100888139  DT.87018106  DT.101985215  DT.91964308  DT.100833934 
    DT.99973456  DT.100888115  DT.100030336  DT.100888141  DT.91765054  DT.95297798  DT.100888125  DT.110632 
    DT.91765071  DT.100888137  DT.121477292  DT.87009659  DT.95256835  DT.100030335  DT.100888118  DT.100888134 

    24/31 AceView cDNA sequences (see all 31):

    CR603961 CR604068 CR599433 CR596741 CR591612 CR596557 CR622853 CR616651 
    CR622938 CR606505 CR614236 CR617299 AK075510 BC008734 CR625984 CR626832 
    CR609370 BX647163 CR597151 CR599170 CR622710 CR596606 CR609658 NM_004107 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for FCGRT (see all 19)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^
    SP1:                          -     -     -     -                                                                                   -     -     -     -     -   
    SP2:                          -     -     -     -                                                                                         -     -               
    SP3:                                                                                                                                -     -     -     -     -   
    SP4:                    -     -     -     -     -                                                                                                               
    SP5:                                      -     -                                                                                                               

    ExUns: 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b
    SP1:  -                       -     -                     
    SP2:                                                      
    SP3:  -                       -     -                     
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for FCGRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCGRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTGAGACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FCGRT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCGRT

    SOURCE GeneReport for Unigene cluster: Hs.111903
        SABiosciences Custom PCR Arrays for FCGRT
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FCGRT gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgrt1 , 5 Fc receptor, IgG, alpha chain transporter1, 5 70.09(n)1
    66.94(a)1
      7 (29.12 cM)5
    141321  NM_010189.31  NP_034319.21 
     450929935 
    chicken
    (Gallus gallus)
    Aves --
    F1NM79_CHICK6
    (see all 15)
    Uncharacterized protein
    (see all 15)
    29(a)
    29(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    Un(62829135-62830402)
    16(40458-41204)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 25)
    --
    34(a)
    29(a)
    (see all 25)
    many ↔ many
    many ↔ many
    (see all 25)
    GL344125.1(5283-12373)
    AAWZ02040156(3915-5955)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-287j19.66
    mhc1zel6
    (see all 7)
    si:ch211-287j19.6
    major histocompatibility complex class I ZE gene, ...
    (see all 7)
    23(a)
    22(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    1(47613228-47619236)
    3(1072354-1093229)


    ENSEMBL Gene Tree for FCGRT (if available)
    TreeFam Gene Tree for FCGRT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCGRT gene
    HLA-F2  MR12  HFE2  HLA-B2  HLA-E2  HLA-C2  HLA-A2  HLA-G2  
    15 SIMAP similar genes for FCGRT using alignment to 10 protein entries:     FCGRN_HUMAN (see all proteins):
    DKFZp686N10220    HLA-A*01    HLA-B*3512    HLA-B35    HLA-G    HLA-F
    HLA-E    HLA-A    HLA-B    HLA-A24AK    HLA-Cw    HLA-C
    HLAC    MHC    MR1

    FCGRT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/354 NCBI SNPs in FCGRT are shown (see all 354    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72462001,2
    C,--50013537(+) ttggaA/Cggctg 1 -- us2k10--------
    rs1390395591,2
    --50013540(+) GAAGGC/TTGAGG 1 -- us2k10--------
    rs1489999361,2
    --50013578(+) AGGCCA/GTCCTG 1 -- us2k10--------
    rs1895747551,2
    --50013633(+) AACCGA/GGTGTG 1 -- us2k10--------
    rs1438275181,2
    --50013686(+) AGGAGA/GATCGC 1 -- us2k10--------
    rs1924402921,2
    --50013699(+) GAACCC/TGGGAG 1 -- us2k10--------
    rs1481368101,2
    --50013740(+) ATTGCA/GCTCCA 1 -- us2k10--------
    rs1848519911,2
    --50013920(+) TCTGTC/TGCCCA 1 -- us2k10--------
    rs1889357701,2
    --50013942(+) AGTGGC/TGGGAT 1 -- us2k10--------
    rs1815630191,2
    --50013974(+) CCTCCC/TGGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCGRT (50015536 - 50029685 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for FCGRT
         3 CNVs: 5111 5110 32261
    Human Gene Mutation Database (HGMD): FCGRT

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FCGRT for disorders           About GeneDecksing

    OMIM gene information: 601437    OMIM disorders: --

    16 diseases for FCGRT:    About MalaCards
    hypoproteinemia, hypercatabolic    persistent fetal circulation syndrome    epidermolysis bullosa acquisita    epidermolysis bullosa
    common variable immunodeficiency    hemochromatosis    lupus nephritis    nephritis
    pemphigus    hepatitis b    purpura    meningioma
    immunodeficiency    hepatitis    arthritis    leukemia

    1 disease from the University of Copenhagen DISEASES database for FCGRT:
    Persistent fetal circulation syndrome

    5 Novoseek disease relationships for FCGRT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypoproteinemia, hypercatabolic 89.2 4 17046328 (1), 16549777 (1)
    igg deficiency 71.7 2 17046328 (1)
    autoimmune diseases 26.8 11 16284651 (1), 19772792 (1), 20092334 (1), 20432181 (1) (see all 5)
    hemochromatosis 20.6 2 11935295 (1), 9523114 (1)
    tumors 2.54 6 16818514 (2), 20354184 (1), 16546710 (1)

    Human Genome Epidemiology (HuGE) Navigator: FCGRT (6 documents)

    Export disorders for FCGRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCGRT gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with FCGRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. (PubMed id 7964511)1, 2, 3 Story C.M.... Simister N.E. (1994)
    2. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. (PubMed id 10933786)1, 2, 9 West A.P. Jr. and Bjorkman P.J. (2000)
    3. Cloning and analysis of the gene encoding the human neonatal Fc receptor. (PubMed id 10998088)1, 2, 9 Mikulska J.E.... Simister N.E. (2000)
    4. The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. (PubMed id 8646894)1, 3, 9 Kandil E....Miyosi O. (1996)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues. (PubMed id 18637944)1, 9 Andersen J.T....Sandlie I. (2008)
    8. N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG. (PubMed id 19164298)1, 9 Kuo T.T....Blumberg R.S. (2009)
    9. Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis. (PubMed id 15644205)1, 9 Zhou J....Ward E.S. (2005)
    10. Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G. (PubMed id 12972260)1, 9 Zhou J....Ward E.S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2217 HGNC: 3621 AceView: FCGRT Ensembl:ENSG00000104870 euGenes: HUgn2217
    ECgene: FCGRT H-InvDB: FCGRT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCGRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCGRT gene:
    Search GeneIP for patents involving FCGRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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