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Aliases for FCGRT Gene

Aliases for FCGRT Gene

  • Fc Fragment Of IgG Receptor And Transporter 2 3 5
  • Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor 2 3
  • Transmembrane Alpha Chain Of The Neonatal Receptor 2 3
  • Fc Fragment Of IgG, Receptor, Transporter, Alpha 2 3
  • IgG Fc Fragment Receptor Transporter Alpha Chain 3 4
  • Neonatal Fc Receptor 3 4
  • FCRN 3 4
  • Major Histocompatibility Complex Class I-Like Fc Receptor 3
  • Immunoglobulin Receptor, Intestinal, Heavy Chain 3
  • IgG Receptor FcRn Large Subunit P51 3
  • Neonatal Fc-Receptor For Ig 3
  • FcRn Alpha Chain 3
  • Alpha-Chain 3

External Ids for FCGRT Gene

Previous GeneCards Identifiers for FCGRT Gene

  • GC19P050674
  • GC19P050384
  • GC19P054691
  • GC19P054707
  • GC19P054708
  • GC19P050015
  • GC19P046393
  • GC19P050028
  • GC19P050047

Summaries for FCGRT Gene

Entrez Gene Summary for FCGRT Gene

  • This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCGRT Gene

FCGRT (Fc Fragment Of IgG Receptor And Transporter) is a Protein Coding gene. Diseases associated with FCGRT include Hypoproteinemia, Hypercatabolic and Immunoglobulin G Deficiency. GO annotations related to this gene include antigen binding and beta-2-microglobulin binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot for FCGRT Gene

  • Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).

Gene Wiki entry for FCGRT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGRT Gene

Genomics for FCGRT Gene

Regulatory Elements for FCGRT Gene

Enhancers for FCGRT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049552 1.4 Ensembl ENCODE dbSUPER 19.3 +48.5 48534 5.7 PKNOX1 CBX3 NFRKB ARID4B ZBTB40 GATA2 CBX5 FOS MIXL1 EGR2 NOSIP PRR12 FCGRT RCN3 PRRG2 MIR150 RPS11 SNORD35B SNORD35A SNORD34
GH19G049921 1.6 FANTOM5 ENCODE dbSUPER 12.9 +416.2 416206 3.4 WRNIP1 YY1 ZNF121 ZNF766 ELK1 ZNF143 FOS KLF7 SP3 CAVIN1 FCGRT NUP62 FLT3LG IL4I1 NR1H2 PTOV1-AS1 ATF5 RPS11 PIR32099
GH19G049532 1.3 Ensembl ENCODE 15.8 +27.0 27017 2.3 HDGF PKNOX1 ATF1 CREB3L1 SIN3A GLIS2 ZNF143 KLF13 ZNF263 SP3 RCN3 FCGRT PRR12 GC19M049536
GH19G050356 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +851.7 851676 3.0 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF766 NAPSB KCNC3 POLD1 FLT3LG LINC01869 C19orf48 SNORD88C FCGRT PNKP NR1H2
GH19G049567 1.5 Ensembl ENCODE dbSUPER 12.4 +62.8 62750 4.6 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF121 ZNF143 PRR12 NOSIP PRRG2 FCGRT MIR150 RPS11 SNORD35B RCN3 FLT3LG IRF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCGRT on UCSC Golden Path with GeneCards custom track

Genomic Location for FCGRT Gene

Chromosome:
19
Start:
49,506,816 bp from pter
End:
49,526,428 bp from pter
Size:
19,613 bases
Orientation:
Plus strand

Genomic View for FCGRT Gene

Genes around FCGRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGRT Gene

Proteins for FCGRT Gene

  • Protein details for FCGRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55899-FCGRN_HUMAN
    Recommended name:
    IgG receptor FcRn large subunit p51
    Protein Accession:
    P55899
    Secondary Accessions:
    • Q5HYM5
    • Q9HBV7
    • Q9NZ19

    Protein attributes for FCGRT Gene

    Size:
    365 amino acids
    Molecular mass:
    39743 Da
    Quaternary structure:
    • FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer.

    Three dimensional structures from OCA and Proteopedia for FCGRT Gene

neXtProt entry for FCGRT Gene

Post-translational modifications for FCGRT Gene

  • Glycosylation at Asn125
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for FCGRT

No data available for DME Specific Peptides for FCGRT Gene

Domains & Families for FCGRT Gene

Gene Families for FCGRT Gene

Suggested Antigen Peptide Sequences for FCGRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55899

UniProtKB/Swiss-Prot:

FCGRN_HUMAN :
  • Belongs to the immunoglobulin superfamily.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with FCGRT: view

Function for FCGRT Gene

Molecular function for FCGRT Gene

GENATLAS Biochemistry:
MHC,class I-like FC receptor,FCGRT
UniProtKB/Swiss-Prot Function:
Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).

Gene Ontology (GO) - Molecular Function for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0019770 IgG receptor activity IBA --
GO:0019864 IgG binding IDA,IEA 7964511
GO:0030881 beta-2-microglobulin binding IBA --
GO:0042605 NOT peptide antigen binding ISS --
genes like me logo Genes that share ontologies with FCGRT: view
genes like me logo Genes that share phenotypes with FCGRT: view

Animal Models for FCGRT Gene

MGI Knock Outs for FCGRT:

Animal Model Products

CRISPR Products

miRNA for FCGRT Gene

miRTarBase miRNAs that target FCGRT

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGRT Gene

Localization for FCGRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGRT Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGRT gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
lysosome 2
endosome 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCGRT: view

Pathways & Interactions for FCGRT Gene

SuperPathways for FCGRT Gene

No Data Available

Interacting Proteins for FCGRT Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000221466%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000399168%0d%0a9606.ENSP00000365817%0d%0a9606.ENSP00000366662%0d%0a9606.ENSP00000295897%0d%0a
Selected Interacting proteins: P55899-FCGRN_HUMAN ENSP00000221466 for FCGRT Gene via IID STRING MINT

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
B2M

Gene Ontology (GO) - Biological Process for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS 7964511
GO:0019882 antigen processing and presentation IBA --
GO:0038094 Fc-gamma receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FCGRT: view

No data available for Pathways by source and SIGNOR curated interactions for FCGRT Gene

Drugs & Compounds for FCGRT Gene

(3) Drugs for FCGRT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FCGRT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGRT: view

Transcripts for FCGRT Gene

Unigene Clusters for FCGRT Gene

Fc fragment of IgG, receptor, transporter, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGRT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - - - - -
SP13: - - - - -
SP14: -
SP15: - - - - -
SP16: - - - - -
SP17:
SP18: - - - - - - - - - - - - - - - -
SP19: - - - - -

ExUns: 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b
SP1: - - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: - -
SP14:
SP15:
SP16: - - - - - - -
SP17:
SP18: - - - - - -
SP19: -

Relevant External Links for FCGRT Gene

GeneLoc Exon Structure for
FCGRT
ECgene alternative splicing isoforms for
FCGRT

Expression for FCGRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCGRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGRT Gene

This gene is overexpressed in Whole Blood (x6.6).

Protein differential expression in normal tissues from HIPED for FCGRT Gene

This gene is overexpressed in Spleen (10.1) and Nasopharynx (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FCGRT Gene



Protein tissue co-expression partners for FCGRT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCGRT Gene:

FCGRT

SOURCE GeneReport for Unigene cluster for FCGRT Gene:

Hs.111903

mRNA Expression by UniProt/SwissProt for FCGRT Gene:

P55899-FCGRN_HUMAN
Tissue specificity: Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.

Evidence on tissue expression from TISSUES for FCGRT Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Liver(4.5)
  • Intestine(3.5)
  • Blood(3.1)
  • Kidney(2.9)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Heart(2.4)
  • Gall bladder(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with FCGRT: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGRT Gene

Orthologs for FCGRT Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCGRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGRT 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia FCGRT 34 35
  • 84.42 (n)
cow
(Bos Taurus)
Mammalia FCGRT 34 35
  • 81.21 (n)
mouse
(Mus musculus)
Mammalia Fcgrt 34 16 35
  • 70.09 (n)
rat
(Rattus norvegicus)
Mammalia Fcgrt 34
  • 69.88 (n)
oppossum
(Monodelphis domestica)
Mammalia FCGRT 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 25 (a)
OneToMany
chicken
(Gallus gallus)
Aves BFIV21 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
BF1 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
Species where no ortholog for FCGRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGRT Gene

ENSEMBL:
Gene Tree for FCGRT (if available)
TreeFam:
Gene Tree for FCGRT (if available)

Paralogs for FCGRT Gene

Variants for FCGRT Gene

Sequence variations from dbSNP and Humsavar for FCGRT Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000021938 -- 49,513,479(+) GTGAG(A/G)GCCGC intron-variant
rs1000499647 -- 49,522,207(+) CTCCA(A/G)AGTAG intron-variant
rs1000512107 -- 49,518,578(+) GCCCA(C/G)ACTGG intron-variant
rs1000910403 -- 49,511,136(+) TGTGG(A/C)TTCTG upstream-variant-2KB
rs1000946663 -- 49,518,197(+) CATCA(C/T)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGRT Gene

Variant ID Type Subtype PubMed ID
esv3644626 CNV loss 21293372
nsv1160655 CNV deletion 26073780
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for FCGRT Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGRT Gene

Human Gene Mutation Database (HGMD)
FCGRT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGRT Gene

Disorders for FCGRT Gene

MalaCards: The human disease database

(6) MalaCards diseases for FCGRT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypoproteinemia, hypercatabolic
  • immunodeficiency 43
immunoglobulin g deficiency
  • igg deficiency
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
epidermolysis bullosa acquisita
  • acquired epidermolysis bullosa
hemochromatosis
  • hfe hemochromatosis, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search FCGRT in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCGRT

Genetic Association Database (GAD)
FCGRT
Human Genome Epidemiology (HuGE) Navigator
FCGRT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGRT
genes like me logo Genes that share disorders with FCGRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGRT Gene

Publications for FCGRT Gene

  1. Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients. (PMID: 19772792) Zhou X.J. … Zhang H. (Clin. Exp. Rheumatol. 2009) 3 22 46 64
  2. Cloning and analysis of the gene encoding the human neonatal Fc receptor. (PMID: 10998088) Mikulska J.E. … Simister N.E. (Eur. J. Immunogenet. 2000) 3 4 22 64
  3. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. (PMID: 10933786) West A.P. Jr. … Bjorkman P.J. (Biochemistry 2000) 3 4 22 64
  4. The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. (PMID: 8646894) Kandil E. … Miyosi O. (Cytogenet. Cell Genet. 1996) 2 3 22 64
  5. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. (PMID: 7964511) Story C.M. … Simister N.E. (J. Exp. Med. 1994) 2 3 4 64

Products for FCGRT Gene

Sources for FCGRT Gene

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