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Aliases for FCGR3B Gene

Aliases for FCGR3B Gene

  • Fc Fragment Of IgG, Low Affinity IIIb, Receptor (CD16b) 2 3
  • IgG Fc Receptor III-1 3 4
  • Fc-Gamma RIII-Beta 3 4
  • Fc-Gamma RIIIb 3 4
  • FCRIIIb 3 4
  • FCR-10 3 4
  • FCRIII 3 4
  • FCGR3 3 4
  • CD16b 3 4
  • FCG3 3 4
  • Fc Fragment Of IgG, Low Affinity IIIb, Receptor For (CD16) 2
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B 3
  • Fc-Gamma Receptor IIIb (CD 16) 3
  • Fc-Gamma RIII 4
  • CD16b Antigen 4
  • IGFR3 4
  • CD16 3

External Ids for FCGR3B Gene

Previous HGNC Symbols for FCGR3B Gene

  • FCGR3
  • FCG3

Previous GeneCards Identifiers for FCGR3B Gene

  • GC01U990046
  • GC01M157244
  • GC01M158289
  • GC01M158782
  • GC01M158783
  • GC01M158325
  • GC01M159859
  • GC01M161592

Summaries for FCGR3B Gene

Entrez Gene Summary for FCGR3B Gene

  • The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]

GeneCards Summary for FCGR3B Gene

FCGR3B (Fc Fragment Of IgG, Low Affinity IIIb, Receptor (CD16b)) is a Protein Coding gene. Diseases associated with FCGR3B include aggressive periodontitis and primary immunodeficiency disease. Among its related pathways are GPCR Pathway and Staphylococcus aureus infection. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR3B Gene

  • Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils

Gene Wiki entry for FCGR3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR3B Gene

Genomics for FCGR3B Gene

Regulatory Elements for FCGR3B Gene

Genomic Location for FCGR3B Gene

Start:
161,623,196 bp from pter
End:
161,631,963 bp from pter
Size:
8,768 bases
Orientation:
Minus strand

Genomic View for FCGR3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR3B Gene

Proteins for FCGR3B Gene

  • Protein details for FCGR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75015-FCG3B_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor III-B
    Protein Accession:
    O75015
    Secondary Accessions:

    Protein attributes for FCGR3B Gene

    Size:
    233 amino acids
    Molecular mass:
    26216 Da
    Quaternary structure:
    • Monomer. Interacts with INPP5D/SHIP1 (By similarity).
    Miscellaneous:
    • Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The Phe-203 in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring

    Three dimensional structures from OCA and Proteopedia for FCGR3B Gene

neXtProt entry for FCGR3B Gene

Proteomics data for FCGR3B Gene at MOPED

Post-translational modifications for FCGR3B Gene

  • Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3
  • The soluble form is produced by a proteolytic cleavage
  • Glycosylation at Asn56, Asn63, Asn82, Asn92, Asn180, and Asn187
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FCGR3B (Fc gamma RIIIB/CD16b)

No data available for DME Specific Peptides for FCGR3B Gene

Domains for FCGR3B Gene

Gene Families for FCGR3B Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCGR3B Gene

Suggested Antigen Peptide Sequences for FCGR3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75015

UniProtKB/Swiss-Prot:

FCG3B_HUMAN :
  • O75015
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCGR3B: view

Function for FCGR3B Gene

Molecular function for FCGR3B Gene

GENATLAS Biochemistry: immunoglobulin G,low affinity Fc receptor 3.2,neutrophil specific,including the allelic neutrophil antigens,with several isoforms,involved in blood transfusion reactions,immune-mediated neutropenia (NA1,NA2 and SH,with SH variant of NA2) (see IGFCR@)
UniProtKB/Swiss-Prot Function: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils

Gene Ontology (GO) - Molecular Function for FCGR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR3B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FCGR3B Gene

Localization for FCGR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR3B Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR3B Gene COMPARTMENTS Subcellular localization image for FCGR3B gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FCGR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCGR3B: view

Pathways for FCGR3B Gene

genes like me logo Genes that share pathways with FCGR3B: view

Interacting Proteins for FCGR3B Gene

Gene Ontology (GO) - Biological Process for FCGR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006955 immune response TAS 2139735
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with FCGR3B: view

Compounds for FCGR3B Gene

(19) Drugbank Compounds for FCGR3B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abciximab
  • 7E3
143653-53-6 target
Adalimumab
331731-18-1 target
Alefacept
222535-22-0 target
Alemtuzumab
216503-57-0 target
Basiliximab
  • chimeric mouse-human antiCD25
152923-56-3 target

(19) Novoseek inferred chemical compound relationships for FCGR3B Gene

Compound -log(P) Hits PubMed IDs
fmlp 64.8 18
cytochalasin b 33.2 5
phosphatidylinositol 29 10
genistein 29 3
superoxide 25.9 2
genes like me logo Genes that share compounds with FCGR3B: view

Transcripts for FCGR3B Gene

Unigene Clusters for FCGR3B Gene

Fc fragment of IgG, low affinity IIIb, receptor (CD16b):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR3B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR3B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for FCGR3B Gene

GeneLoc Exon Structure for
FCGR3B
ECgene alternative splicing isoforms for
FCGR3B

Expression for FCGR3B Gene

mRNA expression in normal human tissues for FCGR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR3B Gene

This gene is overexpressed in Whole Blood (50.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCGR3B Gene

SOURCE GeneReport for Unigene cluster for FCGR3B Gene Hs.694258

mRNA Expression by UniProt/SwissProt for FCGR3B Gene

O75015-FCG3B_HUMAN
Tissue specificity: Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils
genes like me logo Genes that share expressions with FCGR3B: view

In Situ Assay Products

Orthologs for FCGR3B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 88 (a)
OneToMany
FCGR3A 35
  • 98.14 (n)
  • 95.28 (a)
cow
(Bos Taurus)
Mammalia FCGR3A 35
  • 76.11 (n)
  • 62.23 (a)
FCGR3A 36
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
LOC478984 35
  • 75.76 (n)
  • 59.74 (a)
mouse
(Mus musculus)
Mammalia Fcgr4 35
  • 73.25 (n)
  • 62.72 (a)
Fcgr4 36
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fcgr3a 35
  • 71.2 (n)
  • 60.09 (a)
Species with no ortholog for FCGR3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR3B Gene

ENSEMBL:
Gene Tree for FCGR3B (if available)
TreeFam:
Gene Tree for FCGR3B (if available)

Paralogs for FCGR3B Gene

Selected SIMAP similar genes for FCGR3B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FCGR3B: view

Variants for FCGR3B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR3B Gene

O75015-FCG3B_HUMAN
There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides

Sequence variations from dbSNP and Humsavar for FCGR3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs377982 -- 161,632,082(+) CCCCA(C/T)GTTGG upstream-variant-2KB
rs404946 -- 161,632,603(+) ACTTC(A/G)GATGC upstream-variant-2KB
rs418215 -- 161,626,493(+) CTGAG(A/G)CATAA intron-variant
rs428194 -- 161,623,607(+) TGCTT(C/G)TGGTT utr-variant-3-prime
rs429688 -- 161,623,118(+) GATGG(C/T)TGCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FCGR3B Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv85n67 CNV Loss 20364138
nsv819523 CNV Loss 19587683
nsv818489 CNV Gain 17921354
nsv517640 CNV Gain+Loss 19592680
dgv137e1 CNV Complex 17122850
dgv138e1 CNV Complex 17122850
nsv872498 CNV Gain 21882294
essv6858 CNV CNV 17122850
dgv139e1 CNV Complex 17122850
nsv514915 CNV Complex 21397061
nsv818500 CNV Gain 17921354
nsv442209 CNV CNV 18776908
nsv509546 CNV Insertion 20534489
dgv23n16 CNV Insertion 17901297
esv2507888 CNV Deletion 19546169
esv990743 CNV Loss 20482838
nsv821621 CNV Loss 15273396
dgv50e201 CNV Deletion 23290073
dgv75e199 CNV Deletion 23128226
dgv24n16 CNV Insertion 17901297
nsv825242 CNV Loss 20364138
esv3325 CNV Deletion 18987735
esv5752 CNV Loss 19470904
nsv825254 CNV Gain 20364138
esv2670711 CNV Deletion 23128226

Relevant External Links for FCGR3B Gene

HapMap Linkage Disequilibrium report
FCGR3B
Human Gene Mutation Database (HGMD)
FCGR3B

Disorders for FCGR3B Gene

(2) University of Copenhagen DISEASES for FCGR3B Gene

(30) Novoseek inferred disease relationships for FCGR3B Gene

Disease -log(P) Hits PubMed IDs
transfusion reaction 65.7 1
paroxysmal hemoglobinuria nocturnal 60.5 8
leukemia eosinophilic 48.6 1
sjogrens syndrome primary 41.6 1
neutropenia 34 4

Genatlas disease for FCGR3B Gene

autoimmune thyroiditis,recurrent bacterial infections in some FCGR3B deficient people

Relevant External Links for FCGR3B

Genetic Association Database (GAD)
FCGR3B
Human Genome Epidemiology (HuGE) Navigator
FCGR3B
genes like me logo Genes that share disorders with FCGR3B: view

No data available for UniProtKB/Swiss-Prot for FCGR3B Gene

Publications for FCGR3B Gene

  1. The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. (PMID: 7836402) Gessner J.E. … Schmidt R.E. (J. Biol. Chem. 1995) 3 4 23
  2. Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb. (PMID: 9028335) Bux J. … Santoso S. (Blood 1997) 3 4 23
  3. Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis. (PMID: 12858454) Tsuchiya N. … Hashimoto H. (J. Rheumatol. 2003) 3 23 48
  4. Independent association of HLA-DR and FCgamma receptor polymorphisms in Korean patients with systemic lupus erythematosus. (PMID: 12867584) Lee H.S. … Yoo D.H. (Rheumatology (Oxford) 2003) 3 23 48
  5. [FCGR3B gene frequencies and FCGR3 gene variants in Chinese: a study in 487 Chinese individuals from Zhejiang Province]. (PMID: 15500735) Tong Y. … Flesch B. (Zhonghua Yi Xue Za Zhi 2004) 3 23 48

Products for FCGR3B Gene

Sources for FCGR3B Gene

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