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Aliases for FCGR3B Gene

Aliases for FCGR3B Gene

  • Fc Fragment Of IgG Receptor IIIb 2 3
  • Fc Fragment Of IgG, Low Affinity IIIb, Receptor (CD16b) 2 3 5
  • Fc Gamma Receptor IIIb 2 3
  • IgG Fc Receptor III-1 3 4
  • Fc-Gamma RIII-Beta 3 4
  • Fc-Gamma RIIIb 3 4
  • FCRIIIb 3 4
  • FCR-10 3 4
  • FCRIII 3 4
  • FCGR3 3 4
  • CD16b 3 4
  • FCG3 3 4
  • Fc Fragment Of IgG, Low Affinity IIIb, Receptor For (CD16) 2
  • Fc-Gamma Receptor IIIb (CD 16) 3
  • Fc-Gamma RIII 4
  • CD16b Antigen 4
  • IGFR3 4
  • CD16 3

External Ids for FCGR3B Gene

Previous HGNC Symbols for FCGR3B Gene

  • FCGR3
  • FCG3

Previous GeneCards Identifiers for FCGR3B Gene

  • GC01U990046
  • GC01M157244
  • GC01M158289
  • GC01M158782
  • GC01M158783
  • GC01M158325
  • GC01M159859
  • GC01M161592

Summaries for FCGR3B Gene

Entrez Gene Summary for FCGR3B Gene

  • The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]

GeneCards Summary for FCGR3B Gene

FCGR3B (Fc Fragment Of IgG Receptor IIIb) is a Protein Coding gene. Diseases associated with FCGR3B include neutropenia, alloimmune neonatal and paroxysmal nocturnal hemoglobinuria. Among its related pathways are IgA-Producing B Cells in the Intestine and Osteoclast differentiation. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR3B Gene

  • Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Gene Wiki entry for FCGR3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR3B Gene

Genomics for FCGR3B Gene

Regulatory Elements for FCGR3B Gene

Promoters for FCGR3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FCGR3B on UCSC Golden Path with GeneCards custom track

Genomic Location for FCGR3B Gene

Chromosome:
1
Start:
161,623,196 bp from pter
End:
161,631,963 bp from pter
Size:
8,768 bases
Orientation:
Minus strand

Genomic View for FCGR3B Gene

Genes around FCGR3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR3B Gene

Proteins for FCGR3B Gene

  • Protein details for FCGR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75015-FCG3B_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor III-B
    Protein Accession:
    O75015

    Protein attributes for FCGR3B Gene

    Size:
    233 amino acids
    Molecular mass:
    26216 Da
    Quaternary structure:
    • Monomer. Interacts with INPP5D/SHIP1 (By similarity).
    Miscellaneous:
    • Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The Phe-203 in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.

    Three dimensional structures from OCA and Proteopedia for FCGR3B Gene

neXtProt entry for FCGR3B Gene

Proteomics data for FCGR3B Gene at MOPED

Post-translational modifications for FCGR3B Gene

  • Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
  • The soluble form is produced by a proteolytic cleavage.
  • Glycosylation at Asn 56, Asn 63, Asn 82, Asn 92, Asn 180, and Asn 187
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FCGR3B (Fc gamma RIIIB/CD16b)

No data available for DME Specific Peptides for FCGR3B Gene

Domains & Families for FCGR3B Gene

Protein Domains for FCGR3B Gene

Suggested Antigen Peptide Sequences for FCGR3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75015

UniProtKB/Swiss-Prot:

FCG3B_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCGR3B: view

Function for FCGR3B Gene

Molecular function for FCGR3B Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 3.2,neutrophil specific,including the allelic neutrophil antigens,with several isoforms,involved in blood transfusion reactions,immune-mediated neutropenia (NA1,NA2 and SH,with SH variant of NA2) (see IGFCR@)
UniProtKB/Swiss-Prot Function:
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Gene Ontology (GO) - Molecular Function for FCGR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR3B: view
genes like me logo Genes that share phenotypes with FCGR3B: view

Animal Models for FCGR3B Gene

MGI Knock Outs for FCGR3B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGR3B Gene

Localization for FCGR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR3B Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR3B Gene COMPARTMENTS Subcellular localization image for FCGR3B gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FCGR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCGR3B: view

Pathways & Interactions for FCGR3B Gene

genes like me logo Genes that share pathways with FCGR3B: view

Interacting Proteins for FCGR3B Gene

Gene Ontology (GO) - Biological Process for FCGR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2139735
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with FCGR3B: view

No data available for SIGNOR curated interactions for FCGR3B Gene

Drugs & Compounds for FCGR3B Gene

(32) Drugs for FCGR3B Gene - From: Novoseek, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma Target 96,129
Abciximab Approved Pharma Target 64
Adalimumab Approved Pharma Target 443
Alefacept Approved, Withdrawn Pharma Target 40
alemtuzumab Approved, Investigational Pharma Target Therapeutic Antibodies 302

(13) Additional Compounds for FCGR3B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGR3B: view

Transcripts for FCGR3B Gene

Unigene Clusters for FCGR3B Gene

Fc fragment of IgG, low affinity IIIb, receptor (CD16b):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR3B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for FCGR3B Gene

GeneLoc Exon Structure for
FCGR3B
ECgene alternative splicing isoforms for
FCGR3B

Expression for FCGR3B Gene

mRNA expression in normal human tissues for FCGR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR3B Gene

This gene is overexpressed in Whole Blood (x50.1).

Protein differential expression in normal tissues from HIPED for FCGR3B Gene

This gene is overexpressed in Serum (29.7), Urine (17.3), Saliva (7.0), and Spleen (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR3B Gene



SOURCE GeneReport for Unigene cluster for FCGR3B Gene Hs.694258

mRNA Expression by UniProt/SwissProt for FCGR3B Gene

O75015-FCG3B_HUMAN
Tissue specificity: Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
genes like me logo Genes that share expression patterns with FCGR3B: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FCGR3B Gene

Orthologs for FCGR3B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGR3A 35
  • 98.14 (n)
  • 95.28 (a)
-- 36
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FCGR3A 36
  • 58 (a)
OneToMany
FCGR3A 35
  • 76.11 (n)
  • 62.23 (a)
dog
(Canis familiaris)
Mammalia LOC478984 35
  • 75.76 (n)
  • 59.74 (a)
-- 36
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fcgr4 16
Fcgr4 36
  • 57 (a)
OneToMany
Fcgr4 35
  • 73.25 (n)
  • 62.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fcgr3a 35
  • 71.2 (n)
  • 60.09 (a)
Species with no ortholog for FCGR3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR3B Gene

ENSEMBL:
Gene Tree for FCGR3B (if available)
TreeFam:
Gene Tree for FCGR3B (if available)

Paralogs for FCGR3B Gene

(12) SIMAP similar genes for FCGR3B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FCGR3B: view

Variants for FCGR3B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR3B Gene

O75015-FCG3B_HUMAN
There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.

Sequence variations from dbSNP and Humsavar for FCGR3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_003956 -
VAR_003957 -
rs448740 - 161,629,903(+) TGAGG(C/T)TCTCA reference, missense
VAR_003964 -
rs5030738 - 161,629,864(-) TGACG(A/C)TGCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FCGR3B Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv85n67 CNV Loss 20364138
nsv819523 CNV Loss 19587683
nsv818489 CNV Gain 17921354
nsv517640 CNV Gain+Loss 19592680
dgv137e1 CNV Complex 17122850
dgv138e1 CNV Complex 17122850
nsv872498 CNV Gain 21882294
essv6858 CNV CNV 17122850
dgv139e1 CNV Complex 17122850
nsv514915 CNV Complex 21397061
nsv818500 CNV Gain 17921354
nsv442209 CNV CNV 18776908
nsv509546 CNV Insertion 20534489
dgv23n16 CNV Insertion 17901297
esv2507888 CNV Deletion 19546169
esv990743 CNV Loss 20482838
nsv821621 CNV Loss 15273396
dgv50e201 CNV Deletion 23290073
dgv75e199 CNV Deletion 23128226
dgv24n16 CNV Insertion 17901297
nsv825242 CNV Loss 20364138
esv3325 CNV Deletion 18987735
esv5752 CNV Loss 19470904
nsv825254 CNV Gain 20364138
esv2670711 CNV Deletion 23128226

Variation tolerance for FCGR3B Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGR3B Gene

HapMap Linkage Disequilibrium report
FCGR3B
Human Gene Mutation Database (HGMD)
FCGR3B

Disorders for FCGR3B Gene

MalaCards: The human disease database

(7) MalaCards diseases for FCGR3B Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neutropenia, alloimmune neonatal
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
hemoglobinuria
cryptococcosis
  • busse-buschke's disease
poliomyelitis
  • infantile paralysis
- elite association - COSMIC cancer census association via MalaCards

Genatlas disease for FCGR3B Gene

autoimmune thyroiditis,recurrent bacterial infections in some FCGR3B deficient people

Relevant External Links for FCGR3B

Genetic Association Database (GAD)
FCGR3B
Human Genome Epidemiology (HuGE) Navigator
FCGR3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR3B
genes like me logo Genes that share disorders with FCGR3B: view

No data available for UniProtKB/Swiss-Prot for FCGR3B Gene

Publications for FCGR3B Gene

  1. [FCGR3B gene frequencies and FCGR3 gene variants in Chinese: a study in 487 Chinese individuals from Zhejiang Province]. (PMID: 15500735) Tong Y. … Flesch B. (Zhonghua Yi Xue Za Zhi 2004) 3 23 48 67
  2. Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease. (PMID: 19946017) Zhou X.J. … Zhang H. (Int. Immunol. 2010) 3 23
  3. Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients. (PMID: 16110781) Choi E.H. … Chanock S.J. (Med. Mycol. 2005) 3 23
  4. FCGR3B polymorphism in three ethnic Chinese populations. (PMID: 15783303) Yan L. … Fu Q. (Immunohematology 2005) 3 23
  5. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PMID: 15457442) Criswell L.A. … Bridges S.L. (Arthritis Rheum. 2004) 3 25

Products for FCGR3B Gene

Sources for FCGR3B Gene

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