Aliases for FCGR3B Gene
External Ids for FCGR3B Gene
Previous HGNC Symbols for FCGR3B Gene
Previous GeneCards Identifiers for FCGR3B Gene
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
GeneCards Summary for FCGR3B Gene
FCGR3B (Fc Fragment Of IgG Receptor IIIb) is a Protein Coding gene. Diseases associated with FCGR3B include neutropenia, alloimmune neonatal and paroxysmal nocturnal hemoglobinuria. Among its related pathways are IgA-Producing B Cells in the Intestine and Osteoclast differentiation. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.
UniProtKB/Swiss-Prot for FCGR3B Gene
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.