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FCGR3B Gene

protein-coding   GIFtS: 56
GCID: GC01M161592

Fc Fragment Of IgG, Low Affinity IIIb, Receptor (CD16b)

(Previous names: Fc fragment of IgG, low affinity IIIb, receptor for (CD16))
(Previous symbols: FCGR3, FCG3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Fragment Of IgG, Low Affinity IIIb, Receptor (CD16b)1 2     FCRIIIb2
FCG31 2 3     Fc-Gamma Receptor IIIb (CD 16)2
FCGR31 2 3     Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B2
Fc-Gamma RIII-Beta2 3     CD16B3
Fc-Gamma RIIIb2 3     FcR-103
IgG Fc Receptor III-12 3     FcRIII3
Fc Fragment Of IgG, Low Affinity IIIb, Receptor For (CD16)1     FcRIIIb3
CD162     IGFR33
CD16b2     CD16b Antigen3
FCR-102     Fc-Gamma RIII3
FCRIII2     

External Ids:    HGNC: 36201   Entrez Gene: 22152   Ensembl: ENSG000001627477   OMIM: 6106655   UniProtKB: O750153   

Export aliases for FCGR3B gene to outside databases

Previous GC identifers: GC01U990046 GC01M157244 GC01M158289 GC01M158782 GC01M158783 GC01M158325 GC01M159859


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCGR3B Gene:
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The
encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to
capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms
have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1.
(provided by RefSeq, Aug 2012)

GeneCards Summary for FCGR3B Gene:
FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)) is a protein-coding gene. Diseases associated with FCGR3B include neutropenia, alloimmune neonatal, and aggressive periodontitis. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCG3B_HUMAN, O75015
Function: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or
aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent
cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does
not activate neutrophils

Gene Wiki entry for FCGR3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FCGR3B gene promoter:
         Nkx3-1   STAT1   Nkx3-1 v4   Nkx3-1 v1   IRF-1   Nkx3-1 v2   AREB6   IRF-2   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FCGR3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

FCGR3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR3B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161592:  view genomic region     (about GC identifiers)

Start:
161,592,986 bp from pter      End:
161,601,753 bp from pter
Size:
8,768 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FCG3B_HUMAN, O75015 (See protein sequence)
Recommended Name: Low affinity immunoglobulin gamma Fc region receptor III-B precursor  
Size: 233 amino acids; 26216 Da
Subunit: Monomer. Interacts with INPP5D/SHIP1 (By similarity)
Miscellaneous: Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed
in a tissue-specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in
FCGR3B determines the GPI-anchoring
5 PDB 3D structures from and Proteopedia for FCGR3B:
1E4J (3D)        1E4K (3D)        1FNL (3D)        1T83 (3D)        1T89 (3D)    

Explore the universe of human proteins at neXtProt for FCGR3B: NX_O75015

Explore proteomics data for FCGR3B at MOPED

Post-translational modifications: 

  • Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG31
  • The soluble form is produced by a proteolytic cleavage1
  • Glycosylation2 at Asn56, Asn63, Asn82, Asn92, Asn180, Asn187
  • Modification sites at PhosphoSitePlus

  • See FCGR3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000561.3  NP_001231682.1  NP_001257964.1  NP_001257965.1  NP_001257966.1  

    ENSEMBL proteins: 
     ENSP00000356941   ENSP00000433642   ENSP00000394204   ENSP00000437084   ENSP00000294800  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O75015

    ProtoNet protein and cluster: O75015

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: FCG3B_HUMAN, O75015
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    FCGR3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCG3B_HUMAN, O75015
    Function: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or
    aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent
    cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does
    not activate neutrophils

         Genatlas biochemistry entry for FCGR3B:
    immunoglobulin G,low affinity Fc receptor 3.2,neutrophil specific,including the allelic neutrophil antigens,with
    several isoforms,involved in blood transfusion reactions,immune-mediated neutropenia (NA1,NA2 and SH,with SH
    variant of NA2) (see IGFCR@)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019864IgG binding IEA--
         
    FCGR3B for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCG3B_HUMAN, O75015: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    FCGR3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCGR3B About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    NFAT in Immune Response0.58
    2Fc-GammaR Pathway
    Fc-GammaR Pathway0.55
    3RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    4Leishmaniasis
    Leishmaniasis0.35
    5RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FCGR3B
        Fc-GammaR Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages
    NFAT in Immune Response
    Phagocytosis of Microbes



    Selected Kegg Pathways  (Kegg details for FCGR3B) (see all 7):
        Phagosome
    Osteoclast differentiation
    Natural killer cell mediated cytotoxicity
    Leishmaniasis
    Staphylococcus aureus infection


    FCGR3B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCGR3B
    Interactions:

        Search GeneGlobe Interaction Network for FCGR3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for FCGR3B (O750153 ENSP000002948004) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHG1P018573, ENSP000003749904I2D: score=1 STRING: ENSP00000374990
    APCSP027433, ENSP000002550404I2D: score=2 STRING: ENSP00000255040
    CASP7P552103I2D: score=1 
    LILRA6ENSP000003901204STRING: ENSP00000390120 STRING: ENSP00000379651
    PRKCBENSP000003053554STRING: ENSP00000305355
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS2139735

    FCGR3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGR3B (FCG3B)

    Selected DrugBank Compounds for FCGR3B (see all 19)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--1835892 8097750 1900882 2335478 2415663
    TrastuzumabAnti HER2 (see all 2)180288-69-1target--15868915 16109421 14666732 15680154 15471859
    EtanerceptCD120b (see all 7)185243-69-0target--17387033 10800083 15457442 15526004
    RituximabAntiCD20 (see all 2)174722-31-7target--16825493 17475906 16109421 15659493
    Alemtuzumab-- 216503-57-0target--8707338 9337053 9020367
    Gemtuzumab ozogamicinanti-CD33 (see all 2)220578-59-6target--9815888 9649182 7509291
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    Abciximab7E3 (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284

    Selected Novoseek inferred chemical compound relationships for FCGR3B gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmlp 64.8 21 8656040 (5), 11472441 (4), 1321856 (3), 8410601 (1) (see all 9)
    cytochalasin b 33.2 6 11472441 (4), 9717666 (1)
    phosphatidylinositol 29 15 1693531 (5), 1654955 (1), 1311348 (1), 1532472 (1) (see all 6)
    genistein 29 3 8656040 (2), 8477800 (1)
    superoxide 25.9 2 8656040 (1), 1309559 (1)
    tyrosine 23.6 13 7515890 (2), 7523143 (2), 10843711 (1), 7768958 (1) (see all 9)
    n-formylmethionyl-leucylphenylalanine 19.8 3 11472441 (3)
    prednisolone 16.6 2 7893586 (2)
    leukotriene b4 16.2 2 8383692 (1), 7893586 (1)
    dbc-amp 12.5 11 7982855 (3), 8394282 (2)



    FCGR3B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FCGR3B gene (5 alternative transcripts): 
    NM_000570.4  NM_001244753.1  NM_001271035.1  NM_001271036.1  NM_001271037.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367964(uc021pdo.1) ENST00000531221 ENST00000421702 ENST00000533780
    ENST00000534776 ENST00000534489 ENST00000294800(uc009wul.3)
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      QuantiTect SYBR Green Assays in human, mouse, rat FCGR3B
      QuantiFast Probe-based Assays in human, mouse, rat FCGR3B

    Selected AceView cDNA sequences (see all 153):

    BU682376 R93404 S62490 M24853 CB162329 AI207649 AI168567 AW589489 
    CR616259 AA635913 CD364634 AI685467 BF588544 AI147638 AI949189 BE673430 
    AI921177 AW207548 BX452346 CR599546 BX097599 AI767829 X52645 NM_000569 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FCGR3B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                      -     -                           
    SP2:                                            -                           
    SP3:        -                                                               
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for FCGR3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCGR3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FCGR3B Expression
    About this image


    FCGR3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    FCGR3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGR3B Protein Expression

    UniProtKB/Swiss-Prot: FCG3B_HUMAN, O75015
    Tissue specificity: Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by
    stimulated eosinophils

        Custom PCR Arrays for FCGR3B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCGR3B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgr41 Fc receptor, IgG, low affinity IV 73.25(n)
    62.72(a)
      246256  NM_144559.2  NP_653142.2 


    ENSEMBL Gene Tree for FCGR3B (if available)
    TreeFam Gene Tree for FCGR3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCGR3B gene
    FCGR3A1 2  FCGR1B2  FCGR2B2  FCRLB2  FCRL22  FCRL12  FCRLA2  FCRL52  
    FCRL42  FCGR2A2  FCGR1A2  FCRL32  FCER1A2  FCRL62  
    12 SIMAP similar genes for FCGR3B using alignment to 4 protein entries:     FCG3B_HUMAN (see all proteins):
    Fc-gamma receptor IIIB    FCGR3A    FCGR2B    FCGR2C    FCGR2A    FCGR1B
    FCGR1A    FCGR1C    FCRL3    FCER1A    FCRL5    FCRLB

    FCGR3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    FCG3B_HUMAN, O75015: There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and
    SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen
    system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic
    vasculitides


    Selected SNPs for FCGR3B (see all 338)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs673730901,2
    C--161593880(+) TTTTTC/-CCCTC 5 -- ut312Minor allele frequency- -:0.25NA CSA 4
    rs618030101,2
    --161594525(+) GACAAC/GTGCCA 5 -- int12Minor allele frequency- G:0.00NA 8
    rs618030111,2
    --161594526(+) ACAAGG/TGCCAA 5 -- int12Minor allele frequency- T:0.00NA 8
    rs5028561,2
    A,H--161596584(+) GATGAA/GTTGCT 5 -- int14Minor allele frequency- G:0.00NS EA 414
    rs6938401,2
    F,A,H--161596589(+) GTTGCC/TCTATT 5 -- int15Minor allele frequency- T:0.00NS EA NA 422
    rs719199651,2
    C--161599359(+) GCAGC-/TCTATA 5 -- int10--------
    rs1438684371,2
    C--161600288(+) CCCAA-/TTTTCC 5 -- int10--------
    rs5126021,2
    F,A,H--161600516(+) AAATTG/AAAAAC 5 -- int12Minor allele frequency- A:0.29NS 232
    rs5134911,2
    A--161600601(+) CCACAG/TAGTGA 5 -- int1 ut510--------
    rs1453356411,2
    C--168143413(+) GAATCA/GTCTTG 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for FCGR3B (161592986 - 161601753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCGR3B (see all 42):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv75e199CNV Deletion23128226
    esv2507888CNV Deletion19546169
    esv3325CNV Deletion18987735
    dgv50e201CNV Deletion23290073
    esv2718873CNV Deletion23290073
    esv2670711CNV Deletion23128226
    nsv820341CNV Duplication20802225
    dgv24n16CNV Insertion17901297
    nsv509546CNV Insertion20534489
    dgv23n16CNV Insertion17901297

    Human Gene Mutation Database (HGMD): FCGR3B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCGR3B
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGR3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610665    OMIM disorders: --

    Selected diseases for FCGR3B (see all 64):    
    About MalaCards
    neutropenia, alloimmune neonatal    aggressive periodontitis    primary immunodeficiency disease    cryptococcosis
    paroxysmal nocturnal hemoglobinuria    hemoglobinuria    spondylarthropathy    microscopic polyangiitis
    rheumatic fever    vasculitis    poliomyelitis    neutropenia
    nephritis    guillain-barre syndrome    cerebral malaria    adult-onset still's disease
    oral lichen planus    sjogren's syndrome    periodontitis    bullous pemphigoid

    2 diseases from the University of Copenhagen DISEASES database for FCGR3B:
    Systemic lupus erythematosus     Neutropenia

    FCGR3B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FCGR3B gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    transfusion reaction 65.7 1 9028335 (1)
    paroxysmal hemoglobinuria nocturnal 60.5 12 8204883 (2), 1702101 (2), 1835413 (1), 7490518 (1) (see all 6)
    leukemia eosinophilic 48.6 1 8394282 (1)
    sjogrens syndrome primary 41.6 1 7558166 (1)
    neutropenia 34 4 9028335 (2), 9562743 (1), 9359005 (1)
    vasculitis leukocytoclastic 17.6 1 8318044 (1)
    bacterial infections 17 1 2136822 (1)
    rheumatoid arthritis 16.1 4 1309559 (1), 8254199 (1), 8879033 (1), 8660102 (1)
    lymphocytosis 14.4 1 1766265 (1)
    myeloid leukemia chronic 11.2 5 1465030 (2), 8795698 (1)

    Genatlas disease: FCGR3B
    autoimmune thyroiditis,recurrent bacterial infections in some FCGR3B deficient people

    Genetic Association Database (GAD): FCGR3B
    Human Genome Epidemiology (HuGE) Navigator: FCGR3B (101 documents)

    Export disorders for FCGR3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCGR3B gene, integrated from 10 sources (see all 372):
    (articles sorted by number of sources associating them with FCGR3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PubMed id 15457442)1, 4, 7, 9 Criswell L.A....Bridges S.L. (Arthritis Rheum. 2004)
    2. Genetic risk factors for infection in patients with early rheumatoid arthritis. (PubMed id 15526004)1, 4, 7 Hughes L.B....Bridges S.L. (Genes Immun. 2004)
    3. [FCGR3B gene frequencies and FCGR3 gene variants in Chinese: a study in 487 Chinese individuals from Zhejiang Province]. (PubMed id 15500735)1, 4, 9 Tong Y....Flesch B. (Zhonghua Yi Xue Za Zhi 2004)
    4. The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. (PubMed id 7836402)1, 2, 9 Gessner J.E.... Schmidt R.E. (J. Biol. Chem. 1995)
    5. Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb. (PubMed id 9028335)1, 2, 9 Bux J....Santoso S. (Blood 1997)
    6. Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease. (PubMed id 19946017)1, 4, 9 Zhou X.J....Zhang H. (Int. Immunol. 2010)
    7. FCGR3B polymorphism in three ethnic Chinese populations. (PubMed id 15783303)1, 4, 9 Yan L....Fu Q. (Immunohematology 2005)
    8. Patterns of low-affinity immunoglobulin receptor polymorphisms in stroke and homozygous sickle cell disease. (PubMed id 11835346)1, 4, 9 Taylor J.G....Chanock S.J. (Am. J. Hematol. 2002)
    9. Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients. (PubMed id 16110781)1, 4, 9 Choi E.H....Chanock S.J. (Med. Mycol. 2005)
    10. No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS. (PubMed id 12864991)1, 4, 9 Breij E.C....Uitdehaag B.M. (J. Neuroimmunol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2215 HGNC: 3620 AceView: FCGR3A Ensembl:ENSG00000162747 euGenes: HUgn2215
    ECgene: FCGR3B Kegg: 2215 H-InvDB: FCGR3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCGR3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCGR3B gene:
    Search GeneIP for patents involving FCGR3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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