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Aliases for FCGR3A Gene

Aliases for FCGR3A Gene

  • Fc Fragment Of IgG Receptor IIIa 2 3
  • Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a) 2 3 5
  • Fc Gamma Receptor IIIa 2 3
  • IgG Fc Receptor III-2 3 4
  • Fc-Gamma RIII-Alpha 3 4
  • Fc-Gamma RIIIa 3 4
  • Fc-Gamma RIII 3 4
  • CD16a Antigen 3 4
  • FCRIIIA 3 4
  • FCR-10 3 4
  • FCRIII 3 4
  • FCGR3 3 4
  • CD16A 3 4
  • IGFR3 3 4
  • FCG3 3 4
  • Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16) 2
  • Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16) 3
  • Fc Fragment Of IgG Low Affinity IIIa Receptor 3
  • Immunoglobulin G Fc Receptor III 3
  • Fc-Gamma Receptor III-2 (CD 16) 3
  • Neutrophil-Specific Antigen NA 3
  • Fc-Gamma Receptor IIIb (CD16) 3
  • Fc Gamma Receptor III-A 3
  • FcgammaRIIIA 3
  • FCGRIII 3
  • IMD20 3
  • CD16 3

External Ids for FCGR3A Gene

Previous HGNC Symbols for FCGR3A Gene

  • FCGR3
  • FCG3

Previous GeneCards Identifiers for FCGR3A Gene

  • GC01M159227
  • GC01M157243
  • GC01M158288
  • GC01M158780
  • GC01M158324
  • GC01M159778
  • GC01M161511
  • GC01M132836

Summaries for FCGR3A Gene

Entrez Gene Summary for FCGR3A Gene

  • This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCGR3A Gene

FCGR3A (Fc Fragment Of IgG Receptor IIIa) is a Protein Coding gene. Diseases associated with FCGR3A include immunodeficiency 20 and autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity. Among its related pathways are Immune System and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR3A Gene

  • Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Gene Wiki entry for FCGR3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR3A Gene

Genomics for FCGR3A Gene

Regulatory Elements for FCGR3A Gene

Genomic Location for FCGR3A Gene

Chromosome:
1
Start:
161,541,759 bp from pter
End:
161,550,737 bp from pter
Size:
8,979 bases
Orientation:
Minus strand

Genomic View for FCGR3A Gene

Genes around FCGR3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR3A Gene

Proteins for FCGR3A Gene

  • Protein details for FCGR3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08637-FCG3A_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor III-A
    Protein Accession:
    P08637
    Secondary Accessions:
    • A2N6W9
    • Q53FJ0
    • Q53FL6
    • Q5EBR4
    • Q65ZM6
    • Q6PIJ0

    Protein attributes for FCGR3A Gene

    Size:
    254 amino acids
    Molecular mass:
    29089 Da
    Quaternary structure:
    • Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 (By similarity).
    Miscellaneous:
    • Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the Ser-203 in III-B determines the GPI-anchoring.
    SequenceCaution:
    • Sequence=BAD96988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97015.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR3A Gene

neXtProt entry for FCGR3A Gene

Proteomics data for FCGR3A Gene at MOPED

Post-translational modifications for FCGR3A Gene

  • Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
  • The soluble form is produced by a proteolytic cleavage.
  • Glycosylation at Asn 56, Asn 63, Asn 92, Asn 180, and Asn 187
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FCGR3A (Fc gamma RIIIA/CD16a)

No data available for DME Specific Peptides for FCGR3A Gene

Domains & Families for FCGR3A Gene

Protein Domains for FCGR3A Gene

Suggested Antigen Peptide Sequences for FCGR3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08637

UniProtKB/Swiss-Prot:

FCG3A_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCGR3A: view

Function for FCGR3A Gene

Molecular function for FCGR3A Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity receptor 3A (see IGFCR@),expressed in natural killer cells,monocytes and renal mesangial cells
UniProtKB/Swiss-Prot Function:
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
genes like me logo Genes that share phenotypes with FCGR3A: view

Human Phenotype Ontology for FCGR3A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGR3A Gene

Localization for FCGR3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR3A Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR3A Gene COMPARTMENTS Subcellular localization image for FCGR3A gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IDA 10706735
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCGR3A: view

Pathways & Interactions for FCGR3A Gene

genes like me logo Genes that share pathways with FCGR3A: view

Gene Ontology (GO) - Biological Process for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with FCGR3A: view

No data available for SIGNOR curated interactions for FCGR3A Gene

Drugs & Compounds for FCGR3A Gene

(39) Drugs for FCGR3A Gene - From: DrugBank, PharmGKB, Novoseek, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etanercept Approved, Investigational Pharma Target 383
rituximab Approved Pharma Target Therapeutic Antibodies 1582
Trastuzumab Approved, Investigational Pharma Target HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 726
Adalimumab Approved Pharma Target 443
Cetuximab Approved Pharma Target EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 713

(6) Additional Compounds for FCGR3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGR3A: view

Transcripts for FCGR3A Gene

Unigene Clusters for FCGR3A Gene

Fc fragment of IgG, low affinity IIIa, receptor (CD16a):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR3A Gene

No ASD Table

Relevant External Links for FCGR3A Gene

GeneLoc Exon Structure for
FCGR3A
ECgene alternative splicing isoforms for
FCGR3A

Expression for FCGR3A Gene

mRNA expression in normal human tissues for FCGR3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR3A Gene

This gene is overexpressed in Whole Blood (x20.1) and Spleen (x6.7).

Protein differential expression in normal tissues from HIPED for FCGR3A Gene

This gene is overexpressed in Spleen (20.2) and NK cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR3A Gene



SOURCE GeneReport for Unigene cluster for FCGR3A Gene Hs.372679

mRNA Expression by UniProt/SwissProt for FCGR3A Gene

P08637-FCG3A_HUMAN
Tissue specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
genes like me logo Genes that share expression patterns with FCGR3A: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FCGR3A Gene

Orthologs for FCGR3A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGR3A 35
  • 98.95 (n)
  • 96.85 (a)
-- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FCGR3A 36
  • 62 (a)
OneToMany
FCGR3A 35
  • 76 (n)
  • 61.6 (a)
dog
(Canis familiaris)
Mammalia LOC478984 35
  • 75.57 (n)
  • 58.7 (a)
-- 36
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fcgr4 36
  • 62 (a)
OneToMany
Fcgr4 35
  • 72.69 (n)
  • 62.65 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fcgr3a 35
  • 72.02 (n)
  • 60.64 (a)
Species with no ortholog for FCGR3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR3A Gene

ENSEMBL:
Gene Tree for FCGR3A (if available)
TreeFam:
Gene Tree for FCGR3A (if available)

Paralogs for FCGR3A Gene

genes like me logo Genes that share paralogs with FCGR3A: view

Variants for FCGR3A Gene

Sequence variations from dbSNP and Humsavar for FCGR3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs396991 - 161,544,752(-) GGCTT(C/G/T)TTGGG intron-variant, reference, missense
rs10127939 -, Immunodeficiency 20 (IMD20) 161,548,543(-) GAGCC(A/G/T)CATCT reference, missense
rs443082 - 161,544,838(-) CAAAG(A/G)CAGGA intron-variant, reference, missense
rs396716 - 161,544,806(-) ACTTC(C/T)ACATT intron-variant, reference, missense
rs1042206 - 161,543,169(-) ATTCT(C/G/T)TCCAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FCGR3A Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
nsv872494 CNV Gain 21882294
dgv397n71 CNV Gain 21882294
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv22n16 CNV Deletion 17901297
dgv74e199 CNV Deletion 23128226
dgv85n67 CNV Loss 20364138
nsv819523 CNV Loss 19587683
nsv818489 CNV Gain 17921354
nsv517640 CNV Gain+Loss 19592680
dgv137e1 CNV Complex 17122850
dgv138e1 CNV Complex 17122850
nsv872498 CNV Gain 21882294
essv6858 CNV CNV 17122850
dgv139e1 CNV Complex 17122850
nsv514915 CNV Complex 21397061
nsv818500 CNV Gain 17921354
nsv442209 CNV CNV 18776908
dgv1n39 CNV Gain 20164927
nsv509546 CNV Insertion 20534489
dgv23n16 CNV Insertion 17901297
nsv159772 CNV Loss 16902084
esv2507888 CNV Deletion 19546169
esv990743 CNV Loss 20482838

Variation tolerance for FCGR3A Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGR3A Gene

HapMap Linkage Disequilibrium report
FCGR3A
Human Gene Mutation Database (HGMD)
FCGR3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR3A Gene

Disorders for FCGR3A Gene

MalaCards: The human disease database

(9) MalaCards diseases for FCGR3A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 20
  • imd20
autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity
  • autosomal recessive primary immunodeficiency with defective spontaneous nk cell cytotoxicity
systemic lupus erythematosus
  • lupus nephritis
poliomyelitis
  • infantile paralysis
cryptococcosis
  • busse-buschke's disease
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FCG3A_HUMAN
  • Immunodeficiency 20 (IMD20) [MIM:615707]: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). {ECO:0000269 PubMed:23006327, ECO:0000269 PubMed:8608639, ECO:0000269 PubMed:8609432, ECO:0000269 PubMed:8874200}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FCGR3A Gene

lupus systemic syndrome and other autoimmune diseases

Relevant External Links for FCGR3A

Genetic Association Database (GAD)
FCGR3A
Human Genome Epidemiology (HuGE) Navigator
FCGR3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR3A
genes like me logo Genes that share disorders with FCGR3A: view

Publications for FCGR3A Gene

  1. A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa. (PMID: 8609432) de Haas M. … von dem Borne A.E.G.K. (J. Immunol. 1996) 3 4 23 67
  2. Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PMID: 17324336) Hatjiharissi E. … Treon S.P. (Clin Lymphoma Myeloma 2007) 3 23 25
  3. FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma. (PMID: 16609067) Kim D.H. … Sohn S.K. (Blood 2006) 3 23 25
  4. Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease. (PMID: 19946017) Zhou X.J. … Zhang H. (Int. Immunol. 2010) 3 23
  5. Fcgamma receptor IIIA polymorphisms and efficacy of rituximab therapy on Chinese diffuse large B-cell lymphoma. (PMID: 20137370) Zhang W. … Zhou D.B. (Chin. Med. J. 2010) 3 23

Products for FCGR3A Gene

Sources for FCGR3A Gene

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