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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCGR3A Gene

protein-coding   GIFtS: 65
GCID: GC01M161511

Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)

(Previous names: Fc fragment of IgG, low affinity IIIa, receptor for (CD16))
(Previous symbols: FCGR3, FCG3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)1 2     FCRIII2
FCG31 2 3     FCRIIIA2
FCGR31 2 3     FcgammaRIIIA2
IGFR32 3 5     Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16)2
Fc-Gamma RIII2 3     Fc Gamma Receptor III-A2
IgG Fc Receptor III-22 3     Fc-Gamma Receptor III-2 (CD 16)2
CD16A2 3     Fc-Gamma Receptor IIIb (CD16)2
CD16a Antigen2 3     Immunoglobulin G Fc Receptor III2
Fc-Gamma RIII-Alpha2 3     Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A2
Fc-Gamma RIIIa2 3     Neutrophil-Specific Antigen NA2
CD162 5     FcR-103
Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16)1     FcRIII3
FCGRIII2     FcRIIIa3
FCR-102     

External Ids:    HGNC: 36191   Entrez Gene: 22142   Ensembl: ENSG000002037477   OMIM: 1467405   UniProtKB: P086373   

Export aliases for FCGR3A gene to outside databases

Previous GC identifers: GC01M159227 GC01M157243 GC01M158288 GC01M158780 GC01M158324 GC01M159778 GC01M132836


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCGR3A Gene:
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of
antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene
(FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this
gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a
transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is
anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility
to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal
neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FCGR3A Gene: 
FCGR3A (Fc fragment of IgG, low affinity IIIa, receptor (CD16a)) is a protein-coding gene. Diseases associated with FCGR3A include herpes zoster, and lupus erythematosus, systemic, susceptibility, and among its related super-pathways are Immune response Role of DAP12 receptors in NK cells and FCGR activation. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637
Function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates
antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis

Gene Wiki entry for FCGR3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCGR3A gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGR3A promoter sequence
   Search SABiosciences Chromatin IP Primers for FCGR3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

FCGR3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR3A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161511:  view genomic region     (about GC identifiers)

Start:
161,511,549 bp from pter      End:
161,600,917 bp from pter
Size:
89,369 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637 (See protein sequence)
Recommended Name: Low affinity immunoglobulin gamma Fc region receptor III-A precursor  
Size: 254 amino acids; 29089 Da
Subunit: Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3
zeta subunit. Interacts with INPP5D/SHIP1 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Exists also
as a soluble receptor
Miscellaneous: Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed
in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in
III-B determines the GPI-anchoring
Sequence caution: Sequence=BAD96988.1; Type=Erroneous initiation; Sequence=BAD97015.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for FCGR3A:
3AY4 (3D)        3SGJ (3D)        3SGK (3D)    
Secondary accessions: A2N6W9 Q53FJ0 Q53FL6 Q5EBR4 Q65ZM6 Q6PIJ0

Explore the universe of human proteins at neXtProt for FCGR3A: NX_P08637

Explore proteomics data for FCGR3A at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated. Contains high mannose- and complex-type oligosaccharides
  • UniProtKB: The soluble form is produced by a proteolytic cleavage
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08637

  • FCGR3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FCGR3A Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_000560.5  NP_001121064.1  NP_001121065.1  NP_001121067.1  NP_001121068.1  

    ENSEMBL proteins: 
     ENSP00000356946   ENSP00000356944   ENSP00000410180   ENSP00000396567   ENSP00000444971  
     ENSP00000392047   ENSP00000416607  
    Reactome Protein details: P08637
    Human Recombinant Protein Products for FCGR3A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCGR3A (Fc gamma RIIIA/CD16a)
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    OriGene Purified Protein for FCGR3A
    OriGene Protein Over-expression Lysate for FCGR3A
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    Sino Biological Recombinant Protein for FCGR3A
    Sino Biological Cell Lysate for FCGR3A 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IDA10706735
    GO:0016021integral to membrane IEA--

    FCGR3A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P08637

    ProtoNet protein and cluster: P08637

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    FCGR3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCG3A_HUMAN, P08637
    Function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates
    antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis

         Genatlas biochemistry entry for FCGR3A:
    immunoglobulin G,low affinity receptor 3A (see IGFCR@),expressed in natural killer cells,monocytes and renal
    mesangial cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019864IgG binding IEA--
         
    FCGR3A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FCGR3A:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fcgr4):
     homeostasis/metabolism  immune system  no phenotypic analysis  skeleton 

    FCGR3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FCGR3A: Fcgr4tm1.1Rav Fcgr4tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FCGR3A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FCGR3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCGR3A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCGR3A 

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FCGR3A:
    hsa-miR-3690 hsa-miR-370 hsa-miR-330-5p hsa-miR-9* hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidFCGR3A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FCGR3A

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): FCGR3A (NM_000569)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR3A
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                         Customized lentivirus expression plasmids for stable overexpression of FCGR3A 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR3A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FCGR3A About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells0.32
    Natural killer cell mediated cytotoxicity0.31
    2Classical antibody-mediated complement activation
    FCGR activation0.70
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
    Role of phospholipids in phagocytosis0.65
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.80
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    5Leishmaniasis
    Leishmaniasis0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FCGR3A
        Immune response CD16 signaling in NK cells


    1 GeneGo (Thomson Reuters) Pathway for FCGR3A
        Immune response CD16 signaling in NK cells


    5/8        Reactome Pathways for FCGR3A (see all 8)
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    FCGR activation
    Adaptive Immune System
    Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation


    5/8         Kegg Pathways  (Kegg details for FCGR3A) (see all 8):
        Phagosome
    Osteoclast differentiation
    Natural killer cell mediated cytotoxicity
    Fc gamma R-mediated phagocytosis
    Leishmaniasis


    FCGR3A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCGR3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for FCGR3A (P086373 ENSP000003569464) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD38P289073, ENSP000002262794I2D: score=3 STRING: ENSP00000226279
    CD247P209633, ENSP000003547824I2D: score=2 STRING: ENSP00000354782
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    SHC1P293533, ENSP000004013034I2D: score=2 STRING: ENSP00000401303
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS2138330
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--
    GO:0050776regulation of immune response TAS--

    FCGR3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCGR3A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FCGR3A (FCG3A)

    10/19 DrugBank Compounds for FCGR3A (see all 19)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alefacept-- 222535-22-0target--12795239 17139284 17016423 11970990
    CetuximabAnti EGFR (see all 2)205923-56-4target--17139284 17704420 17016423
    Gemtuzumab ozogamicinanti-CD33 (see all 2)220578-59-6target--17016423 17139284 7509291
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    RituximabAntiCD20 (see all 2)174722-31-7target--15448014 16609067 17324336
    Abciximab7E3 (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--17139284 17016423

    10/20 Novoseek inferred chemical compound relationships for FCGR3A gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rituximab 66.5 27 15448014 (3), 15659493 (3), 17324336 (2), 15231679 (2) (see all 14)
    valine 43.4 17 16181633 (2), 9276722 (2), 14563637 (2), 17324336 (1) (see all 6)
    phenylalanine 42.3 17 16181633 (2), 14563637 (2), 16609067 (1), 9276722 (1) (see all 5)
    trastuzumab 40.5 1 18347005 (1)
    fmlp 36.9 4 2166753 (1), 1370419 (1)
    etanercept 30.9 1 17265480 (1)
    tyrosine 28.3 18 7819147 (4), 8405050 (3), 8294866 (1), 8408649 (1) (see all 12)
    mannose 22.9 6 9378972 (1), 16110781 (1), 12626795 (1)
    herbimycin a 19.4 1 8405050 (1)
    ivig 18.1 2 14984503 (1), 2208790 (1)

    2 PharmGKB related drug/compound annotations for FCGR3A gene    About this table
    Drug/compound PharmGKB Annotation
    cetuximabCA  
    rituximabCA  

    Search CenterWatch for drugs/clinical trials and news about FCGR3A / FCG3A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCGR3A gene (5 alternative transcripts): 
    NM_000569.6  NM_001127592.1  NM_001127593.1  NM_001127595.1  NM_001127596.1  

    Unigene Cluster for FCGR3A:

    Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
    Hs.372679  [show with all ESTs]
    Unigene Representative Sequence: NM_000569
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367969(uc001gar.3 uc001gas.3) ENST00000367967 ENST00000426740
    ENST00000476031 ENST00000442336 ENST00000540048 ENST00000443193 ENST00000436743(uc001gat.4 uc009wuh.3 uc009wui.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR3A
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    Additional mRNA sequence: 

    AK223268.1 AK223295.1 AK302126.1 BC017865.1 BC033678.1 BC036723.1 M24853.1 S62490.1 
    S76824.1 X52645.1 

    18 DOTS entries:

    DT.100789099  DT.452982  DT.100789100  DT.99977857  DT.121462512  DT.100789097  DT.121462584  DT.91745408 
    DT.121462476  DT.121462513  DT.205850  DT.121462528  DT.121462567  DT.100654312  DT.121462519  DT.121462576 
    DT.121462583  DT.95108899 

    24/153 AceView cDNA sequences (see all 153):

    AI654240 AW273116 CR614832 BX399366 AI685467 AA487334 X52645 AI949189 
    CR599546 R93404 AA700858 BU682376 AI147638 AI921177 M24853 BX452346 
    CD364634 BF588544 NM_000569 S62490 AI168567 AI207649 AA635913 AW589489 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCGR3A expression in normal human tissues (normalized intensities)      FCGR3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATAAAAT
    FCGR3A Expression
    About this image


    FCGR3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Natural killer-like cells ( Derivation of hematopoietic progenitor cells and natural...
     
     Adipose (Muscoskeletal System)
             Adipose-derived stromal cells
     
     Mesenchymal Stem Cells
             Adipose-derived stromal cells

    See FCGR3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCGR3A

    SOURCE GeneReport for Unigene cluster: Hs.372679

    UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637
    Tissue specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes
    and placental trophoblasts

        SABiosciences Expression via Pathway-Focused PCR Array including FCGR3A: 
              Antifungal Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FCGR3A gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgr41 , 5 Fc receptor, IgG, low affinity IV1, 5 72.69(n)1
    62.65(a)1
      1 (78.53 cM)5
    2462561  NM_144559.21  NP_653142.21 
     1710189205 
    chicken
    (Gallus gallus)
    Aves FCRL26
    Fc receptor family member
    13(a)
    1 → many
    25(1587904-1591630)


    ENSEMBL Gene Tree for FCGR3A (if available)
    TreeFam Gene Tree for FCGR3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCGR3A gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  
    FCRL42  FCGR2A2  FCGR1A2  FCRL32  FCER1A2  FCRL62  
    11 SIMAP similar genes for FCGR3A using alignment to 5 protein entries:     FCG3A_HUMAN (see all proteins):
    FCGR3B    Fc-gamma receptor IIIB    FCGR2B    FCGR2C    FCGR2A    FCGR1C
    FCGR1A    FCGR1B    FCRL3    FCER1A    FCRL5

    FCGR3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/852 SNPs in FCGR3A are shown (see all 852)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481813391,2
    C,Funtested1168068863(+) ACCGAT/CATGGA 10 /I /V mis11Minor allele frequency- C:0.16EU 867
    rs1455577721,2
    Cuntested1168068883(+) GCACCG/AGGTCA 10 /P /L mis11Minor allele frequency- A:0.00NA 4552
    rs2007277851,2
    Cuntested1168068935(+) GTCGTC/TGACTG 10 N D mis10--------
    rs771444851,2
    C,Funtested1168068985(+) TGAGGC/TTCTCA 10 N S mis11Minor allele frequency- T:0.05EU 640
    rs2004752801,2
    Cuntested1168069071(+) AGCACC/GCTGTA 10 S R mis10--------
    rs101279391,2,4
    C,Fother1168068982(-) GAGCCA/G/TCATCT 10 H L mis110NA NS EA WA EU 6195
    rs37676511,2
    C--132838969(-) AAGTTC/G/TCCCTA 1 -- int10--------
    rs40475261,2
    C,F,A,H--132839433(+) AGCTAA/CCCCAA 1 -- int13Minor allele frequency- C:0.33NA 6
    rs174108891,2
    C,F--132839449(+) TGGACT/GGAAAC 1 -- int110Minor allele frequency- G:0.02NA NS EA 574
    rs4512901,2
    C,A,H--132839583(+) TGTGAG/TTGCAG 1 -- int14Minor allele frequency- T:0.09MN NA 99

    HapMap Linkage Disequilibrium report for FCGR3A (161511549 - 161600917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/39 variations for FCGR3A (see all 39):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv74e199CNV Deletion23128226
    esv2507888CNV Deletion19546169
    esv2718873CNV Deletion23290073
    dgv22n16CNV Deletion17901297
    nsv820341CNV Duplication20802225
    nsv509546CNV Insertion20534489
    dgv23n16CNV Insertion17901297
    esv990743CNV Loss20482838
    nsv159772CNV Loss16902084
    nsv819523CNV Loss19587683


    Human Gene Mutation Database (HGMD): FCGR3A

    Locus Specific Mutation Databases (LSDB): FCGR3A
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146740   
    OMIM disorders: 152700  
    20/87 diseases for FCGR3A (see all 87):    About MalaCards
    herpes zoster    lupus erythematosus, systemic, susceptibility    primary immunodeficiency disease    classic kaposi sarcoma
    adult-onset still's disease    cryptococcosis    lupus erythematosus    systemic lupus erythematosus
    complex regional pain syndrome    neutropenia    microscopic polyangiitis    lupus nephritis
    poliomyelitis    nephritis    heparin-induced thrombocytopenia    waldenstrom macroglobulinemia
    severe congenital neutropenia    macroglobulinemia    folliculitis    periodontitis


    FCGR3A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/24 Novoseek inferred disease relationships for FCGR3A gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 50 9 9276722 (2), 16221721 (1), 15181284 (1), 17457599 (1) (see all 6)
    lupus erythematosus systemic 45 9 12209518 (2), 12215903 (1), 16221721 (1), 11263776 (1) (see all 8)
    nephritis 44.9 5 11263776 (1), 11480843 (1), 17596285 (1)
    rheumatoid arthritis 44.2 16 12379528 (2), 17265480 (1), 16221721 (1), 16542359 (1) (see all 12)
    chronic periodontitis 44.1 1 14687231 (1)
    lupus nephritis 39.5 3 11229467 (1), 9746856 (1)
    lymphoma non-hodgkins 30 1 17650444 (1)
    dermatitis atopic 22.5 2 10848732 (1), 9241965 (1)
    lymphoma follicular 19.4 1 14563637 (1)
    necrosis 16.2 6 17265480 (1), 12858454 (1), 14984503 (1), 16142749 (1) (see all 6)

    Genatlas disease: FCGR3A
    lupus systemic syndrome and other autoimmune diseases

    Genetic Association Database (GAD): FCGR3A
    Human Genome Epidemiology (HuGE) Navigator: FCGR3A (162 documents)

    Export disorders for FCGR3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCGR3A gene, integrated from 9 sources (see all 484):
    (articles sorted by number of sources associating them with FCGR3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PubMed id 17324336)1, 4, 7, 9 Hatjiharissi E....Treon S.P. (2007)
    2. FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma. (PubMed id 16609067)1, 4, 7, 9 Kim D.H....Sohn S.K. (2006)
    3. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PubMed id 15457442)1, 4, 7, 9 Criswell L.A....Bridges S.L. (2004)
    4. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. (PubMed id 17704420)1, 4, 7 Zhang W....Lenz H.J. (2007)
    5. FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia. (PubMed id 15217834)1, 4, 7 Lin T.S....Byrd J.C. (2005)
    6. Genetic risk factors for infection in patients with early rheumatoid arthritis. (PubMed id 15526004)1, 4, 7 Hughes L.B....Bridges S.L. (2004)
    7. A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa. (PubMed id 8609432)1, 2, 9 de Haas M.... von dem Borne A.E.G.K. (1996)
    8. Genetic susceptibility and haplotype analysis between Fcgamma receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population. (PubMed id 18625651)1, 4, 9 Pan F....Ye D.Q. (2008)
    9. A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. (PubMed id 9276722)1, 2, 9 Wu J.... Kimberly R.P. (1997)
    10. Flow cytometric assay for determination of FcgammaRIIIA-158 V/F polymorphism. (PubMed id 16181633)1, 4, 9 Bottcher S....Pott C. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2214 HGNC: 3619 AceView: FCGR3A Ensembl:ENSG00000203747 euGenes: HUgn2214
    ECgene: FCGR3A Kegg: 2214 H-InvDB: FCGR3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCGR3A Pharmacogenomics, SNPs, Pathways
    FCGR3Abasehttp://bioinf.uta.fi/FCGR3Abase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FCGR3A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCGR3A gene:
    Search GeneIP for patents involving FCGR3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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