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Aliases for FCGR3A Gene

Aliases for FCGR3A Gene

  • Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a) 2 3
  • IGFR3 3 4 6
  • IgG Fc Receptor III-2 3 4
  • Fc-Gamma RIII-Alpha 3 4
  • Fc-Gamma RIIIa 3 4
  • Fc-Gamma RIII 3 4
  • CD16a Antigen 3 4
  • FCRIIIA 3 4
  • FCR-10 3 4
  • FCRIII 3 4
  • FCGR3 3 4
  • IMD20 3 6
  • CD16A 3 4
  • FCG3 3 4
  • CD16 3 6
  • Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16) 2
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A 3
  • Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16) 3
  • Immunoglobulin G Fc Receptor III 3
  • Fc-Gamma Receptor III-2 (CD 16) 3
  • Neutrophil-Specific Antigen NA 3
  • Fc-Gamma Receptor IIIb (CD16) 3
  • Fc Gamma Receptor III-A 3
  • FcgammaRIIIA 3
  • FCGRIII 3

External Ids for FCGR3A Gene

Previous Symbols for FCGR3A Gene

  • FCGR3
  • FCG3

Summaries for FCGR3A Gene

Entrez Gene Summary for FCGR3A Gene

  • This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCGR3A Gene

FCGR3A (Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)) is a Protein Coding gene. Diseases associated with FCGR3A include herpes zoster and immunodeficiency 20. Among its related pathways are Class I MHC mediated antigen processing and presentation and Creation of C4 and C2 activators. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR3A Gene

  • Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Gene Wiki entry for FCGR3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR3A Gene

Genomics for FCGR3A Gene

Genomic Location for FCGR3A Gene

Start:
161,541,759 bp from pter
End:
161,550,737 bp from pter
Size:
8,979 bases
Orientation:
Minus strand

Genomic View for FCGR3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR3A Gene

Regulatory Elements for FCGR3A Gene

Proteins for FCGR3A Gene

  • Protein details for FCGR3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08637-FCG3A_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor III-A
    Protein Accession:
    P08637
    Secondary Accessions:
    • A2N6W9
    • Q53FJ0
    • Q53FL6
    • Q5EBR4
    • Q65ZM6
    • Q6PIJ0

    Protein attributes for FCGR3A Gene

    Size:
    254 amino acids
    Molecular mass:
    29089 Da
    Quaternary structure:
    • Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 (By similarity).
    Miscellaneous:
    • Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the Ser-203 in III-B determines the GPI-anchoring
    SequenceCaution:
    • Sequence=BAD96988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97015.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR3A Gene

neXtProt entry for FCGR3A Gene

Proteomics data for FCGR3A Gene at MOPED

Post-translational modifications for FCGR3A Gene

  • Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
  • The soluble form is produced by a proteolytic cleavage
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn56, Asn63, Asn92, Asn180, and Asn187

Other Protein References for FCGR3A Gene

No data available for DME Specific Peptides for FCGR3A Gene

Domains for FCGR3A Gene

Gene Families for FCGR3A Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCGR3A Gene

UniProtKB/Swiss-Prot:

FCG3A_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • P08637
genes like me logo Genes that share domains with FCGR3A: view

Function for FCGR3A Gene

Molecular function for FCGR3A Gene

GENATLAS Biochemistry: immunoglobulin G,low affinity receptor 3A (see IGFCR@),expressed in natural killer cells,monocytes and renal mesangial cells
UniProtKB/Swiss-Prot Function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Gene Ontology (GO) - Molecular Function for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR3A: view
genes like me logo Genes that share phenotypes with FCGR3A: view

Animal Models for FCGR3A Gene

MGI Knock Outs for FCGR3A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FCGR3A Gene

Localization for FCGR3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR3A Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR3A Gene COMPARTMENTS Subcellular localization image for FCGR3A gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 10706735
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCGR3A: view

Pathways for FCGR3A Gene

genes like me logo Genes that share pathways with FCGR3A: view

Gene Ontology (GO) - Biological Process for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2138330
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with FCGR3A: view

Compounds for FCGR3A Gene

(19) Drugbank Compounds for FCGR3A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abciximab
  • 7E3
143653-53-6 target
Adalimumab
331731-18-1 target
Alefacept
222535-22-0 target
Alemtuzumab
216503-57-0 target
Basiliximab
  • chimeric mouse-human antiCD25
152923-56-3 target

(20) Novoseek inferred chemical compound relationships for FCGR3A Gene

Compound -log(P) Hits PubMed IDs
rituximab 66.5 23
valine 43.4 9
phenylalanine 42.3 7
trastuzumab 40.5 1
fmlp 36.9 2

(2) PharmGKB related drug/compound annotations for FCGR3A Gene

Drug/compound Annotation
cetuximab CA
rituximab CA
genes like me logo Genes that share compounds with FCGR3A: view

Transcripts for FCGR3A Gene

Unigene Clusters for FCGR3A Gene

Fc fragment of IgG, low affinity IIIa, receptor (CD16a):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR3A Gene

No ASD Table

Relevant External Links for FCGR3A Gene

GeneLoc Exon Structure for
FCGR3A
ECgene alternative splicing isoforms for
FCGR3A

Expression for FCGR3A Gene

mRNA expression in normal human tissues for FCGR3A Gene

mRNA differential expression in normal tissues according to GTEx for FCGR3A Gene

This gene is overexpressed in Whole Blood (20.1) and Spleen (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCGR3A Gene

SOURCE GeneReport for Unigene cluster for FCGR3A Gene Hs.372679

mRNA Expression by UniProt/SwissProt for FCGR3A Gene

P08637-FCG3A_HUMAN
Tissue specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts
genes like me logo Genes that share expressions with FCGR3A: view

Orthologs for FCGR3A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
FCGR3A 36
  • 98.95 (n)
  • 96.85 (a)
cow
(Bos Taurus)
Mammalia FCGR3A 36
  • 76 (n)
  • 61.6 (a)
FCGR3A 37
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 58 (a)
OneToMany
LOC478984 36
  • 75.57 (n)
  • 58.7 (a)
mouse
(Mus musculus)
Mammalia Fcgr4 36
  • 72.69 (n)
  • 62.65 (a)
Fcgr4 16
Fcgr4 37
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 40 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fcgr3a 36
  • 72.02 (n)
  • 60.64 (a)
Species with no ortholog for FCGR3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR3A Gene

ENSEMBL:
Gene Tree for FCGR3A (if available)
TreeFam:
Gene Tree for FCGR3A (if available)

Paralogs for FCGR3A Gene

Selected SIMAP similar genes for FCGR3A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FCGR3A: view

Variants for FCGR3A Gene

Sequence variations from dbSNP and Humsavar for FCGR3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15811 -- 161,541,895(-) TGAAA(A/G)AAAGC utr-variant-3-prime
rs370077 -- 161,543,913(-) GTTCT(A/G)TAGCA intron-variant
rs371849 -- 161,543,914(-) GGTTC(C/T)GTAGC intron-variant
rs375794 -- 161,542,365(+) TTGGA(A/G)ATGGT utr-variant-3-prime
rs386340 -- 161,547,001(+) AAGGA(A/T)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGR3A Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
nsv872494 CNV Gain 21882294
dgv397n71 CNV Gain 21882294
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv22n16 CNV Deletion 17901297
dgv74e199 CNV Deletion 23128226
dgv85n67 CNV Loss 20364138
nsv819523 CNV Loss 19587683
nsv818489 CNV Gain 17921354
nsv517640 CNV Gain+Loss 19592680
dgv137e1 CNV Complex 17122850
dgv138e1 CNV Complex 17122850
nsv872498 CNV Gain 21882294
essv6858 CNV CNV 17122850
dgv139e1 CNV Complex 17122850
nsv514915 CNV Complex 21397061
nsv818500 CNV Gain 17921354
nsv442209 CNV CNV 18776908
dgv1n39 CNV Gain 20164927
nsv509546 CNV Insertion 20534489
dgv23n16 CNV Insertion 17901297
nsv159772 CNV Loss 16902084
esv2507888 CNV Deletion 19546169
esv990743 CNV Loss 20482838

Relevant External Links for FCGR3A Gene

HapMap Linkage Disequilibrium report
FCGR3A
Human Gene Mutation Database (HGMD)
FCGR3A
Locus Specific Mutation Databases (LSDB)
FCGR3A

Disorders for FCGR3A Gene

(1) OMIM Diseases for FCGR3A Gene (146740)

UniProtKB/Swiss-Prot

FCG3A_HUMAN
  • Immunodeficiency 20 (IMD20) [MIM:615707]: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). Note=The disease is caused by mutations affecting the gene represented in this entry. {ECO:0000269 PubMed:23006327, ECO:0000269 PubMed:8608639, ECO:0000269 PubMed:8609432, ECO:0000269 PubMed:8874200}.

(24) Novoseek inferred disease relationships for FCGR3A Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 50 7
lupus erythematosus systemic 45 9
nephritis 44.9 3
rheumatoid arthritis 44.2 13
chronic periodontitis 44.1 1

Genatlas disease for FCGR3A Gene

lupus systemic syndrome and other autoimmune diseases

Relevant External Links for FCGR3A

Genetic Association Database (GAD)
FCGR3A
Human Genome Epidemiology (HuGE) Navigator
FCGR3A
genes like me logo Genes that share disorders with FCGR3A: view

Publications for FCGR3A Gene

  1. FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma. (PMID: 16609067) Kim D.H. … Sohn S.K. (Blood 2006) 3 23 25 49
  2. Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PMID: 17324336) Hatjiharissi E. … Treon S.P. (Clin Lymphoma Myeloma 2007) 3 23 25 49
  3. The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. (PMID: 7836402) Gessner J.E. … Schmidt R.E. (J. Biol. Chem. 1995) 3 4 23
  4. Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa- 48L/R/H phenotype. (PMID: 9242542) Koene H.R. … de Haas M. (Blood 1997) 3 4 23
  5. A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. (PMID: 9276722) Wu J. … Kimberly R.P. (J. Clin. Invest. 1997) 3 4 23

Products for FCGR3A Gene

Sources for FCGR3A Gene

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