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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FCGR3A Gene

protein-coding GIFtS: 67
GCID: GC01M161511

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

(Previous names: Fc fragment of IgG, low affinity IIIa, receptor for (CD16)...)
(Previous symbols: FCGR3, FCG3)

Explore 92 diseases affiliated with
FCGR3A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)¹ ²		FCR-10²
FCG3¹ ² ³		FCRIII²
FCGR3¹ ² ³		FCRIIIA²
CD16¹ ² ⁵		FcgammaRIIIA²
IGFR3² ³ ⁵		Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16)²
Fc-Gamma RIII² ³		Fc Gamma Receptor III-A²
IgG Fc Receptor III-2² ³		Fc-Gamma Receptor III-2 (CD 16)²
CD16A² ³		Fc-Gamma Receptor IIIb (CD16)²
CD16a Antigen² ³		Immunoglobulin G Fc Receptor III²
Fc-Gamma RIII-Alpha² ³		Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A²
Fc-Gamma RIIIa² ³		Neutrophil-Specific Antigen NA²
CD16a¹		FcR-10³
Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16)¹		FcRIII³
FCGRIII²		FcRIIIa³

External Ids:	HGNC: 3619¹	Entrez Gene: 2214²	Ensembl: ENSG00000203747⁷	OMIM: 146740⁵	UniProtKB: P08637³

Export aliases for FCGR3A gene to outside databases

Previous GC identifers: GC01M159227 GC01M157243 GC01M158288 GC01M158780 GC01M158324 GC01M159778 GC01M132836

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCGR3A:

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of

antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene

(FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene

is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane

peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a

phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral

infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637

Function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates

antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis

Gene Wiki entry for FCGR3A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FCGR3A gene promoter:
Nkx3-1 v2 Nkx3-1 Nkx3-1 v4 Nkx3-1 v3 Nkx3-1 v1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCGR3A promoter sequence

Search SABiosciences Chromatin IP Primers for FCGR3A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR3A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23

FCGR3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR3A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M161511: view genomic region (about GC identifiers)

Start:	161,511,549 bp from pter	End:	161,600,917 bp from pter
Size:	89,369 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637 (See protein sequence)

Recommended Name: Low affinity immunoglobulin gamma Fc region receptor III-A precursor

Size: 254 amino acids; 29089 Da

Subunit: Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta

subunit. Interacts with INPP5D/SHIP1 (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Exists also as a

soluble receptor

Miscellaneous: Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a

tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in III-B

determines the GPI-anchoring

Sequence caution: Sequence=BAD96988.1; Type=Erroneous initiation; Sequence=BAD97015.1; Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for FCGR3A:

3AY4 (3D)

3SGJ (3D)

3SGK (3D)

Secondary accessions: A2N6W9 Q53FJ0 Q53FL6 Q5EBR4 Q65ZM6 Q6PIJ0

Explore the universe of human proteins at neXtProt for FCGR3A: NX_P08637

Post-translational modifications:

Glycosylated. Contains high mannose- and complex-type oligosaccharides¹

The soluble form is produced by a proteolytic cleavage¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08637

FCGR3A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_000560.5 NP_001121064.1 NP_001121065.1 NP_001121067.1 NP_001121068.1

ENSEMBL proteins:

ENSP00000356946 ENSP00000356944 ENSP00000410180 ENSP00000396567 ENSP00000444971

ENSP00000392047 ENSP00000416607

Reactome Protein details: P08637
Human Recombinant Protein Products:

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	Uscn Proteins for FCGR3A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	IDA	10706735
GO:0016021	integral to membrane	IEA	--

FCGR3A for ontologies About GeneDecksing

FCGR3A Antibody Products:

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	ThermoFisher Antibody for FCGR3A

Assay Products for FCGR3A:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FCGR3A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FCGR3A for domains About GeneDecksing

3 InterPro domains/families:

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P08637

ProtoNet protein and cluster: P08637

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637

Function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates

antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis

Genatlas biochemistry entry for FCGR3A:

immunoglobulin G,low affinity receptor 3A (see IGFCR@),expressed in natural killer cells,monocytes and renal mesangial

cells

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		hsa-miR-3690 hsa-miR-370 hsa-miR-330-5p hsa-miR-9* hsa-miR-326
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCGR3A (see all 4) OriGene shRNA RFP: FCGR3A OriGene siRNA: FCGR3A
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR3A

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0019864	IgG binding	IEA	--

FCGR3A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FCGR3A:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for FCGR3A: Fcgr4^tm1.1Rav Fcgr4^tm1Lex
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fcgr4):

homeostasis/metabolism

immune system

no phenotypic analysis

skeleton

FCGR3A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cleavage of Alpha-1-Microglobulin

	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts	0.66			Role of phospholipids in phagocytosis	0.53
	FCGR activation	0.65			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.30

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Regulation of actin dynamics for phagocytic cup formation

	Regulation of actin dynamics for phagocytic cup formation	1.00			Fcgamma receptor (FCGR) dependent phagocytosis	0.80
	Role of myosins in phagosome formation	0.80

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

Systemic lupus erythematosus

Systemic lupus erythematosus

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FCGR3A

Immune response CD16 signaling in NK cells

1 GeneGo (Thomson Reuters) Pathway for FCGR3A

Immune response CD16 signaling in NK cells

5/10 Reactome Pathways for FCGR3A (see all 10)

	Role of myosins in phagosome formation
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	FCGR activation
	Adaptive Immune System
	Fcgamma receptor (FCGR) dependent phagocytosis

5/8 Kegg Pathways (Kegg details for FCGR3A) (see all 8):

	Phagosome
	Osteoclast differentiation
	Natural killer cell mediated cytotoxicity
	Fc gamma R-mediated phagocytosis
	Leishmaniasis

FCGR3A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FCGR3A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for FCGR3A (P08637³ ENSP00000356946⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD38	P28907³, ENSP00000226279⁴	I2D: score=3 STRING: ENSP00000226279
CD247	P20963³, ENSP00000354782⁴	I2D: score=2 STRING: ENSP00000354782
LCK	P06239³, ENSP00000337825⁴	I2D: score=2 STRING: ENSP00000337825
SHC1	P29353³, ENSP00000401303⁴	I2D: score=2 STRING: ENSP00000401303
ZAP70	P43403³, ENSP00000264972⁴	I2D: score=2 STRING: ENSP00000264972

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	2138330
GO:0050776	regulation of immune response	TAS	--

FCGR3A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FCGR3A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FCGR3A

10/19 DrugBank Compounds for FCGR3A (see all 19) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alefacept	--	222535-22-0	target	--	12795239 17139284 17016423 11970990
Cetuximab	Anti EGFR (see all 2)	205923-56-4	target	--	17139284 17704420 17016423
Gemtuzumab ozogamicin	anti-CD33 (see all 2)	220578-59-6	target	--	17016423 17139284 7509291
Intravenous Immunoglobulin	Ig alpha-2 chain C region (see all 3)	9007-83-4	target	antagonist	17351760 20441428 17911465
Rituximab	AntiCD20 (see all 2)	174722-31-7	target	--	15448014 16609067 17324336
Abciximab	7E3 antibody (see all 4)	143653-53-6	target	--	17016423 17139284
Adalimumab	--	331731-18-1	target	--	17016423 17139284
Basiliximab	chimeric mouse-human antiCD25 (see all 2)	152923-56-3	target	--	17016423 17139284
Bevacizumab	antiVEGF (see all 3)	216974-75-3	target	--	17139284 17016423
Daclizumab	Anti-IL-2 (see all 3)	152923-56-3	target	--	17139284 17016423

10/20 Novoseek chemical compound relationships for FCGR3A gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rituximab	66.5	27	15448014 (3), 15659493 (3), 17324336 (2), 15231679 (2) (see all 14)
valine	43.4	17	16181633 (2), 9276722 (2), 14563637 (2), 17324336 (1) (see all 6)
phenylalanine	42.3	17	16181633 (2), 14563637 (2), 16609067 (1), 9276722 (1) (see all 5)
trastuzumab	40.5	1	18347005 (1)
fmlp	36.9	4	2166753 (1), 1370419 (1)
etanercept	30.9	1	17265480 (1)
tyrosine	28.3	18	7819147 (4), 8405050 (3), 8294866 (1), 8408649 (1) (see all 12)
mannose	22.9	6	9378972 (1), 16110781 (1), 12626795 (1)
herbimycin a	19.4	1	8405050 (1)
ivig	18.1	2	14984503 (1), 2208790 (1)

2 PharmGKB related drug/compound annotations for FCGR3A gene

Drug/compound	PharmGKB Annotation
cetuximab	CA
rituximab	CA

About this table

Search CenterWatch for drugs/clinical trials and news about FCGR3A / FCG3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FCGR3A gene (5 alternative transcripts):

NM_000569.6 NM_001127592.1 NM_001127593.1 NM_001127595.1 NM_001127596.1

Unigene Cluster for FCGR3A:

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Hs.372679 [show with all ESTs]

Unigene Representative Sequence: NM_000569

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367969(uc001gar.3 uc001gas.3) ENST00000367967 ENST00000426740

ENST00000476031 ENST00000442336 ENST00000540048 ENST00000443193 ENST00000436743(uc001gat.4 uc009wuh.3 uc009wui.3)

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		hsa-miR-3690 hsa-miR-370 hsa-miR-330-5p hsa-miR-9* hsa-miR-326
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Additional cDNA sequence:

AK223268.1 AK223295.1 AK302126.1 BC017865.1 BC033678.1 BC036723.1 M24853.1 S62490.1

S76824.1 X52645.1

18 DOTS entries:

DT.100789099 DT.452982 DT.100789100 DT.99977857 DT.121462512 DT.100789097 DT.121462584 DT.91745408

DT.121462476 DT.121462513 DT.205850 DT.121462528 DT.121462567 DT.100654312 DT.121462519 DT.121462576

DT.121462583 DT.95108899

24/153 AceView cDNA sequences (see all 153):

BF588544 BE673430 AW207548 AI685467 BU682376 AW589489 AI921177 AI147638

M24853 AI767829 R93404 BX452346 S62490 AA635913 AI654240 CB162329

AI949189 CR616259 CR604666 NM_000569 CR614832 CR599546 CD364634 AI207649

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FCGR3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAATAAAAT

About this image

FCGR3A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Natural killer-like cells (Derivation of hemato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FCGR3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCGR3A

SOURCE GeneReport for Unigene cluster: Hs.372679

UniProtKB/Swiss-Prot: FCG3A_HUMAN, P08637

Tissue specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and

placental trophoblasts

SABiosciences Expression via Pathway-Focused PCR Array including FCGR3A:

Antifungal Response in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR3A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FCGR3A gene from 1/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	--	16(a)	1 → many	25(1707231-1709870)

ENSEMBL Gene Tree for FCGR3A (if available)
TreeFam Gene Tree for FCGR3A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for FCGR3A gene

FCGR2B² FCGR1B² FCGR3B² FCRL2² FCRLB² FCRL1² FCRL4² FCRL5²

FCRLA² FCGR1A² FCGR2A² FCRL3² FCER1A² FCRL6²

11 SIMAP similar genes for FCGR3A using alignment to 4 protein entries: FCG3A_HUMAN (see all proteins):

FCGR3B Fc-gamma receptor IIIB FCGR2B FCGR2C FCGR2A FCGR1B

FCGR1C FCGR1A FCRL3 FCER1A FCRL5

FCGR3A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200475280^1,2	C	pathogenic	147159207(+)	`AGCACA/C/GCTGTA`	3	S R	mis¹		0	--	--	--	--
rs77144485^1,2	C,F	pathogenic	147159293(+)	`TGAGGC/TTCTCA`	2	N S	mis¹		2		NA EU	5054
rs200727785^1,2	C	pathogenic	147159343(+)	`GTCGTC/TGACTG`	2	N D	mis¹		0	--	--	--	--
rs148181339^1,2	C,F,	pathogenic	147159415(+)	`ACCGAT/CATGGA`	2	/I /V	mis¹		2		NA EU	4711
rs10127939^1,2	C,F,	other	147159296(-)	`GAGCCA/C/G/T CATCT`	4	H P R L	mis¹		10		NA NS EA WA EU	6195
rs145557772^1,2	C	other	147159395(+)	`GCACCG/AGGTCA`	2	/P /L	mis¹		1		NA	4552
rs1042223^1,2	H,	--	132837228(-)	`GATTGC/GGGTGG`	1	--	ut3¹ ese³		5		MN NS EA	588
rs114081727^1,2	C,	--	132837242(+)	`NNNNCC/ACTTCC`	1	--	ut3¹		1		NA	120
rs1042222^1,2	A	--	132837259(-)	`AGTAGA/CAAATG`	1	--	ut3¹		2		MN NA	186
rs375794^1,2	A,	--	132837301(+)	`TTGGAG/AATGGT`	1	--	ut3¹ ese³		2		MN NA	186

HapMap Linkage Disequilibrium report for FCGR3A (161511549 - 161600917 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for FCGR3A
15/17 CNVs (see all 17): 6791 48149 22935 3316 58342 65090 38950 4258 48148 9375 2329 97532 65089 31666 8335
Human Gene Mutation Database (HGMD): FCGR3A

Locus Specific Mutation Databases (LSDB): FCGR3A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCGR3A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FCGR3A for disorders           About GeneDecksing

OMIM gene information: 146740
OMIM disorders: 152700
20/92 diseases for FCGR3A (see all 92):    About MalaCards

systemic lupus erythematosus lupus erythematosus neutropenia heparin-induced thrombocytopenia

adult-onset still's disease viral infections, recurrent diffuse large b-cell lymphoma guillain-barre syndrome

complex regional pain syndrome lupus erythematosus, systemic, susceptibility microscopic polyangiitis herpes zoster

b-cell lymphomas classic kaposi sarcoma waldenstrom macroglobulinemia severe congenital neutropenia

non-hodgkin lymphoma systemic lupus erythematosus, association with bullous pemphigoid lupus nephritis

10/24 Novoseek disease relationships for FCGR3A gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune diseases	50	9	9276722 (2), 16221721 (1), 15181284 (1), 17457599 (1) (see all 6)
lupus erythematosus systemic	45	9	12209518 (2), 12215903 (1), 16221721 (1), 11263776 (1) (see all 8)
nephritis	44.9	5	11263776 (1), 11480843 (1), 17596285 (1)
rheumatoid arthritis	44.2	16	12379528 (2), 17265480 (1), 16221721 (1), 16542359 (1) (see all 12)
chronic periodontitis	44.1	1	14687231 (1)
lupus nephritis	39.5	3	11229467 (1), 9746856 (1)
lymphoma non-hodgkins	30	1	17650444 (1)
dermatitis atopic	22.5	2	10848732 (1), 9241965 (1)
lymphoma follicular	19.4	1	14563637 (1)
necrosis	16.2	6	17265480 (1), 12858454 (1), 14984503 (1), 16142749 (1) (see all 6)

Genatlas disease: FCGR3A

lupus systemic syndrome and other autoimmune diseases

Genetic Association Database (GAD): FCGR3A
Human Genome Epidemiology (HuGE) Navigator: FCGR3A (162 documents)

Export disorders for FCGR3A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FCGR3A gene, integrated from 9 sources (see all 462):
(articles sorted by number of sources associating them with FCGR3A)

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world of online information

The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PubMed id 15457442)^{1, 4, 7, 9} Criswell L.A....Bridges S.L. (2004)
FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia. (PubMed id 15217834)^{1, 4, 7} Lin T.S....Byrd J.C. (2005)
Genetic risk factors for infection in patients with early rheumatoid arthritis. (PubMed id 15526004)^{1, 4, 7} Hughes L.B....Bridges S.L. (2004)
A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa. (PubMed id 8609432)^{1, 2, 9} de Haas M.... von dem Borne A.E.G.K. (1996)
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. (PubMed id 9276722)^{1, 2, 9} Wu J.... Kimberly R.P. (1997)
Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PubMed id 17324336)^{1, 7, 9} Hatjiharissi E....Treon S.P. (2007)
FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma. (PubMed id 16609067)^{1, 7, 9} Kim D.H....Sohn S.K. (2006)
Flow cytometric assay for determination of FcgammaRIIIA-158 V/F polymorphism. (PubMed id 16181633)^{1, 4, 9} Bottcher S....Pott C. (2005)
[Polymorphism of Fc gamma RIIIA-158F/V gene and promoter region of IL-10 gene in systemic lupus erythematosus in Kazakhs] (PubMed id 12847896)^{1, 4, 9} Guseva I.A....Miakotkin V.A. (2003)
Polymorphisms in FcgammaRIIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenstrom's macroglobulinemia. (PubMed id 15659493)^{1, 4, 9} Treon S.P....Fox E.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2214	HGNC: 3619	AceView: FCGR3A	Ensembl:ENSG00000203747	euGenes: HUgn2214
ECgene: FCGR3A	Kegg: 2214	H-InvDB: FCGR3A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FCGR3A	Pharmacogenomics, SNPs, Pathways
FCGR3Abase	http://bioinf.uta.fi/FCGR3Abase/
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FCGR3A

Intellectual Property for FCGR3A gene
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Patent Information for FCGR3A gene:
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FCGR3A Gene

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

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FCGR3A (Gene Symbol)
Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)
FCG3
FCGR3
CD16
IGFR3
Fc-Gamma RIII
IgG Fc Receptor III-2
CD16A
CD16a Antigen
Fc-Gamma RIII-Alpha
Fc-Gamma RIIIa
CD16a
Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16)
FCGRIII
FCR-10
FCRIII
FCRIIIA
FcgammaRIIIA
Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16)
Fc Gamma Receptor III-A
Fc-Gamma Receptor III-2 (CD 16)
Fc-Gamma Receptor IIIb (CD16)
Immunoglobulin G Fc Receptor III
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A
Neutrophil-Specific Antigen NA
FcR-10
FcRIII
FcRIIIa

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FCGR3A Gene

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

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