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FCGR2C Gene

protein-coding   GIFtS: 51
GCID: GC01P161551

Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32)...

(Previous names: Fc fragment of IgG, low affinity IIc, receptor for (CD32))
  See FCGR2C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32)
(Gene/Pseudogene)1 2
     Fc Gamma Receptor IIC2
CD322 3     fc-gamma-RIIc2
FCG22 3     Immunoglobulin G Fc Receptor II-C2
IGFR22 3     Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C2
IgG Fc Receptor II-C2 3     CDw323
CD32C2 5     Fc-gamma-RIIc3
Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32)1     FcRII-c3
CDW322     CD32 Antigen3
FCRIIC2     Fc-Gamma RII-C3

External Ids:    HGNC: 156261   Entrez Gene: 91032   Ensembl: ENSG000002446827   OMIM: 6121695   UniProtKB: P319953   
ORGUL members:         

Export aliases for FCGR2C gene to outside databases

Previous GC identifers: GC01U990219 GC01P158364 GC01P159817


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCGR2C Gene:
This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the
surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in
phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and
non-coding variants. (provided by RefSeq, Apr 2012)

GeneCards Summary for FCGR2C Gene:
FCGR2C (Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)) is a protein-coding gene. Diseases associated with FCGR2C include autoimmune thrombocytopenic purpura, and purpura. GO annotations related to this gene include IgG binding and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot: FCG2C_HUMAN, P31995
Function: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a
variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody
production by B-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGR2C gene promoter:
         STAT5B   STAT1   AML1a   HSF2   STAT1beta   Hand1   STAT1alpha   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FCGR2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

FCGR2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR2C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161551:  view genomic region     (about GC identifiers)

Start:
161,551,129 bp from pter      End:
161,575,452 bp from pter
Size:
24,324 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCG2C_HUMAN, P31995 (See protein sequence)
Recommended Name: Low affinity immunoglobulin gamma Fc region receptor II-c precursor  
Size: 323 amino acids; 35578 Da
Caution: Has sometimes been attributed to correspond to FcR-IIB
Sequence caution: Sequence=CAA35643.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for FCGR2C:
3WJL (3D)    
Secondary accessions: O00523 O00524 O00525
Alternative splicing: 4 isoforms:  P31995-1   P31995-2   P31995-3   P31995-4   

Explore the universe of human proteins at neXtProt for FCGR2C: NX_P31995

Explore proteomics data for FCGR2C at MOPED

Post-translational modifications: 

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK1
  • Glycosylation2 at Asn106, Asn180, Asn187
  • Modification sites at PhosphoSitePlus

  • See FCGR2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_963857.3  
    ENSEMBL proteins: 
     ENSP00000426627   ENSP00000444663  

    FCGR2C Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FCGR2C 

     
    antibodies-online proteins for FCGR2C (4 products) 

     
    antibodies-online peptides for FCGR2C

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    antibodies-online kits for FCGR2C (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P31995

    ProtoNet protein and cluster: P31995

    UniProtKB/Swiss-Prot: FCG2C_HUMAN, P31995
    Domain: Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator
    motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCGR2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCG2C_HUMAN, P31995
    Function: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a
    variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody
    production by B-cells

         Genatlas biochemistry entry for FCGR2C:
    immunoglobulin G,low affinity Fc receptor 2C (see IGFCR@2),primarily expressed by cells of the myeloid lineage

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS2531080
    GO:0005515protein binding IPI17474147
    GO:0019864IgG binding IEA--
         
    Find genes that share ontologies with FCGR2C           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FCGR2C

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCG2C_HUMAN, P31995: Isoform IIC4: Cytoplasm (Probable)
    FCG2C_HUMAN, P31995: Isoform IIC3: Cell membrane; Single-pass type I membrane protein
    FCG2C_HUMAN, P31995: Isoform IIC2: Cell membrane; Single-pass type I membrane protein
    FCG2C_HUMAN, P31995: Isoform IIC1: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane NAS2531080

    Find genes that share ontologies with FCGR2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCGR2C About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Leishmaniasis
    Leishmaniasis0.35
    3Tuberculosis
    Tuberculosis
    4Staphylococcus aureus infection
    Staphylococcus aureus infection
    5Phagosome
    Phagosome


    Find genes that share SuperPaths with FCGR2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Kegg Pathways  (Kegg details for FCGR2C):
        Phagosome
    Osteoclast differentiation
    Leishmaniasis
    Staphylococcus aureus infection
    Tuberculosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCGR2C
    Interactions:

        GeneGlobe Interaction Network for FCGR2C

    Selected Interacting proteins for FCGR2C (P319951, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3MINT-8111199 I2D: score=3 
    PLCG1P191742, 3MINT-8112531 I2D: score=3 
    SRCP129312, 3MINT-8113107 I2D: score=3 
    NCK1P163331, 3EBI-1396036,EBI-389883 I2D: score=2 
    CRPP027411, 3EBI-1396036,EBI-1395983 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS2531080
    GO:0007165signal transduction NAS2531080

    Find genes that share ontologies with FCGR2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGR2C (FCG2C)

    Selected DrugBank Compounds for FCGR2C (see all 19)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    Abciximab7E3 (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Alemtuzumab-- 216503-57-0target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    CetuximabAnti EGFR (see all 2)205923-56-4target--17139284 17016423
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423

    1 Novoseek inferred chemical compound relationship for FCGR2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.1 1 10704309 (1)



    Find genes that share compounds with FCGR2C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCGR2C gene (4 alternative transcripts): 
    NM_201563.5  NM_001005410.2  NM_001005411.2  NM_001005412.1  

    Unigene Cluster for FCGR2C:

    Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
    Hs.656750  [show with all ESTs]
    Unigene Representative Sequence: NR_047648
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502411 ENST00000496692 ENST00000466542(uc009wuk.2 uc021pdh.1 uc021pdi.1)
    ENST00000465075(uc009wuj.2) ENST00000473530(uc021pdj.1) ENST00000473712
    ENST00000482226 ENST00000467903 ENST00000507374 ENST00000508651 ENST00000543859

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      QuantiTect SYBR Green Assays in human, mouse, rat FCGR2C
      QuantiFast Probe-based Assays in human, mouse, rat FCGR2C

    Additional mRNA sequence: 

    AK307162.1 AK308168.1 BC137397.1 BC137423.1 NR_047648.1 U90938.1 U90939.1 U90940.1 
    X17652.1 

    23 DOTS entries:

    DT.100819780  DT.87018412  DT.121462515  DT.121462594  DT.92449395  DT.100774280  DT.100650618  DT.85104268 
    DT.92449424  DT.95156067  DT.95156079  DT.97844845  DT.100819775  DT.91650634  DT.95156070  DT.97844847 
    DT.100819781  DT.121462532  DT.91750802  DT.100819773  DT.121462522  DT.75182529  DT.95132159 

    Selected AceView cDNA sequences (see all 509):

    X51758 CD367627 X62572 U87564 NM_001002275 AU098758 CR606721 BX118947 
    BQ017030 BU620984 BM978253 U87565 BF591739 CD367192 U87561 BM717638 
    AI735695 AI523174 AB051387 U87569 BG435504 BC031992 BM671898 BQ019205 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCGR2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCACACT
    FCGR2C Expression
    About this image


    FCGR2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)
    FCGR2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGR2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656750

    UniProtKB/Swiss-Prot: FCG2C_HUMAN, P31995
    Tissue specificity: Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer
    cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for FCGR2C (if available)
    TreeFam Gene Tree for FCGR2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCGR2C gene
    9 SIMAP similar genes for FCGR2C using alignment to 2 protein entries:     FCG2C_HUMAN (see all proteins):
    FCGR2B    FCGR2A    FCGR3B    FCGR3A    Fc-gamma receptor IIIB    FCGR1A
    FCGR1B    FCGR1C    FCER1A

    Find genes that share paralogs with FCGR2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCGR2C (see all 375)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823510351,2
    --161549163(+) AAGAAA/GGAAGG 2 -- us2k10--------
    rs1852241291,2
    --161549167(+) AGGAAA/GGAAGG 2 -- us2k10--------
    rs1904260141,2
    --161549171(+) AGGAAA/GGAAGG 2 -- us2k10--------
    rs1490405041,2
    C--161549210(+) AAAGAA/CAGAAA 2 -- us2k10--------
    rs2010604301,2
    C--161549246(+) AAAGAA/CAGAAA 2 -- us2k10--------
    rs2015510231,2
    C--161549247(+) AAGAC-/AGAA  
            
    AGAAA
    2 -- us2k10--------
    rs1996977361,2
    C--161549250(+) ACAGAA/CAGAAA 2 -- us2k10--------
    rs64276121,2
    C,A--161549253(+) gaaagA/Gaagga 2 -- us2k10--------
    rs46570841,2
    C,A--161549261(+) ggaagC/Aaagaa 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs38204531,2
    C,F,A,H--161549360(-) atgtaC/Ttgtct 2 -- us2k13Minor allele frequency- T:0.50WA CSA 6

    HapMap Linkage Disequilibrium report for FCGR2C (161551129 - 161575452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCGR2C (see all 43):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv74e199CNV Deletion23128226
    dgv75e199CNV Deletion23128226
    esv2507888CNV Deletion19546169
    esv3325CNV Deletion18987735
    dgv50e201CNV Deletion23290073
    esv2718873CNV Deletion23290073
    dgv22n16CNV Deletion17901297
    nsv820341CNV Duplication20802225
    dgv24n16CNV Insertion17901297
    nsv509546CNV Insertion20534489

    Human Gene Mutation Database (HGMD): FCGR2C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCGR2C
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGR2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612169   
    OMIM disorders: 188030  
    2 diseases for FCGR2C:    
    About MalaCards
    autoimmune thrombocytopenic purpura    purpura


    Find genes that share disorders with FCGR2C           About GenesLikeMe

    2 Novoseek inferred disease relationships for FCGR2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 36.4 1 15895258 (1)
    lupus erythematosus systemic 20.6 1 15077320 (1)

    Genetic Association Database (GAD): FCGR2C
    Human Genome Epidemiology (HuGE) Navigator: FCGR2C (2 documents)

    Export disorders for FCGR2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FCGR2C gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with FCGR2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. (PubMed id 2531080)1, 2, 3 Stuart S.G....Mellman I. (EMBO J. 1989)
    2. SNPs of Fc-gamma receptor genes and chronic periodontitis. (PubMed id 20439936)1, 4 Chai L....Leung W.K. (J. Dent. Res. 2010)
    3. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    4. Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. (PubMed id 9516136)1, 2 Metes D....Morel P.A. (Blood 1998)
    5. Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B. (PubMed id 19309690)1, 9 Breunis W.B....Kuijpers T.W. (Hum. Mutat. 2009)
    6. Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus. (PubMed id 23261299)1 Mueller M....Aitman T.J. (Am. J. Hum. Genet. 2013)
    7. FcI^R gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response. (PubMed id 23778324)1 Makowsky R....Shrestha S. (Pharmacogenet. Genomics 2013)
    8. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    9. Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles. (PubMed id 22198951)1 van der Heijden J....Kuijpers T.W. (J. Immunol. 2012)
    10. Comments on: Iwasaki et al. Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. (PubMed id 20978933)1 Pandey J.P. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9103 HGNC: 15626 AceView: HSPA6andFCGR2A Ensembl:ENSG00000244682 euGenes: HUgn9103
    ECgene: FCGR2C Kegg: 9103 H-InvDB: FCGR2C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FCGR2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCGR2C gene:
    Search GeneIP for patents involving FCGR2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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