Aliases for FCGR2C Gene
Aliases for FCGR2C Gene
- Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene) 2 3 5
- Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) 2 3
- IgG Fc Receptor II-C 3 4
- Fc-Gamma-RIIc 3 4
- CDw32 3 4
- IGFR2 3 4
- FCG2 3 4
- CD32 3 4
- Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) (Gene/Pseudogene) 2
- Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C 3
External Ids for FCGR2C Gene
- HGNC: 15626
- Entrez Gene: 9103
- Ensembl: ENSG00000244682
- OMIM: 612169
- UniProtKB: P31995
Previous GeneCards Identifiers for FCGR2C Gene
- GC01U990219
- GC01P158364
- GC01P159817
Summaries for FCGR2C Gene
-
This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]
GeneCards Summary for FCGR2C Gene
FCGR2C (Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with FCGR2C include Thrombocytopenic Purpura, Autoimmune. Among its related pathways are Toxoplasmosis and Role of phospholipids in phagocytosis. GO annotations related to this gene include transmembrane signaling receptor activity and IgG binding. An important paralog of this gene is FCGR2A.
UniProtKB/Swiss-Prot for FCGR2C Gene
-
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2C Gene
Genomics for FCGR2C Gene
Regulatory Elements for FCGR2C Gene
Enhancers for FCGR2C Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCGR2C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCGR2C gene promoter:
Regulatory Element Products
Genomic Location for FCGR2C Gene
- Chromosome:
- 1
- Start:
- 161,581,339 bp from pter
- End:
- 161,605,662 bp from pter
- Size:
- 24,324 bases
- Orientation:
- Plus strand
Genomic View for FCGR2C Gene
Genes around FCGR2C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC
FCGR2C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCGR2C Gene
Proteins for FCGR2C Gene
-
Protein details for FCGR2C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31995-FCG2C_HUMAN
- Recommended name:
- Low affinity immunoglobulin gamma Fc region receptor II-c
- Protein Accession:
- P31995
- O00523
- O00524
- O00525
Protein attributes for FCGR2C Gene
- Size:
- 323 amino acids
- Molecular mass:
- 35578 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAA35643.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FCGR2C Gene
Post-translational modifications for FCGR2C Gene
- Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.
- Glycosylation at Asn106, Asn180, and isoforms=2, 3, 4187
- Modification sites at PhosphoSitePlus
Other Protein References for FCGR2C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FCGR2C (Fc gamma RIIC/CD32c)
- Invitrogen Antibodies for FCGR2C
- antibodies-online Antibodies for FCGR2C: See all 192
- GeneTex FCGR2C antibody for FCGR2C
-
Santa Cruz Biotechnology (SCBT) Antibodies for FCGR2C
Protein Products
- R&D Systems Proteins and Enzymes for FCGR2C (Fc gamma RIIC/CD32c)
-
OriGene Purified Proteins for FCGR2C
- Search Origene for MassSpec and Protein Over-expression Lysates for FCGR2C
- Origene Custom Protein Services for FCGR2C
- Novus Biologicals lysates for FCGR2C
- antibodies-online Proteins for FCGR2C: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FCGR2C
Assay Products
- R&D Systems ELISAs and other biochemical assays for FCGR2C (Fc gamma RIIC/CD32c)
- antibodies-online Kits for FCGR2C: See all 12
No data available for DME Specific Peptides for FCGR2C Gene
Domains & Families for FCGR2C Gene
Gene Families for FCGR2C Gene
- HGNC:
Protein Domains for FCGR2C Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCGR2C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31995UniProtKB/Swiss-Prot:
FCG2C_HUMAN :- Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.
- Domain:
-
- Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.
Function for FCGR2C Gene
Molecular function for FCGR2C Gene
- GENATLAS Biochemistry:
- immunoglobulin G,low affinity Fc receptor 2C (see IGFCR),primarily expressed by cells of the myeloid lineage
- UniProtKB/Swiss-Prot Function:
- Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | NAS | 2531080 |
| GO:0005515 | protein binding | IPI | 17474147 |
| GO:0019864 | IgG binding | IEA | -- |
Phenotypes for FCGR2C Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FCGR2C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGR2C gene
- Search ViGene Biosciences for FCGR2C
CRISPR Products
-
OriGene CRISPR knockouts for FCGR2C
miRNA Products
- Search ViGene Biosciences for FCGR2C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCGR2C
- Browse OriGene Inhibitory RNA Products For FCGR2C
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGR2C gene
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FCGR2C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCGR2C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGR2C gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGR2C Gene
Localization for FCGR2C Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCGR2C Gene
- Isoform IIC4: Cytoplasm.
- Isoform IIC3: Cell membrane; Single-pass type I membrane protein.
- Isoform IIC2: Cell membrane; Single-pass type I membrane protein.
- Isoform IIC1: Cell membrane; Single-pass type I membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,NAS | 2531080 |
No data available for Subcellular locations from COMPARTMENTS for FCGR2C Gene
Pathways & Interactions for FCGR2C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Regulation of actin dynamics for phagocytic cup formation | ||
| 3 | Role of phospholipids in phagocytosis |
.39
|
|
| 4 | Toxoplasmosis |
.35
|
|
| 5 | Osteoclast differentiation | ||
Pathways by source for FCGR2C Gene
1 BioSystems pathway for FCGR2C Gene
7 Reactome pathways for FCGR2C Gene
5 KEGG pathways for FCGR2C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | NAS | 2531080 |
| GO:0007165 | signal transduction | IEA | -- |
No data available for SIGNOR curated interactions for FCGR2C Gene
Drugs & Compounds for FCGR2C Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Abciximab | Approved | Pharma | Target | 65 | ||
| Adalimumab | Approved | Pharma | Target | 494 | ||
| Alefacept | Approved, Withdrawn | Pharma | Target | 40 | ||
| alemtuzumab | Approved, Investigational | Pharma | Target | Therapeutic Antibodies | 310 | |
| Basiliximab | Approved, Investigational | Pharma | Target | 138 |
Transcripts for FCGR2C Gene
mRNA/cDNA for FCGR2C Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (509) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCGR2C Gene
CRISPR Products
-
OriGene CRISPR knockouts for FCGR2C
miRNA Products
- Search ViGene Biosciences for FCGR2C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCGR2C
- Browse OriGene Inhibitory RNA Products For FCGR2C
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGR2C gene
Flow Cytometry Products
Expression for FCGR2C Gene
mRNA differential expression in normal tissues according to GTEx for FCGR2C Gene
This gene is overexpressed in Whole Blood (x5.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FCGR2C Gene
NURSA nuclear receptor signaling pathways regulating expression of FCGR2C Gene:
FCGR2CSOURCE GeneReport for Unigene cluster for FCGR2C Gene:
Hs.656750mRNA Expression by UniProt/SwissProt for FCGR2C Gene:
P31995-FCG2C_HUMAN
Tissue specificity:
Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.
Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR2C Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
Organs:
General:
- blood
- blood vessel
- coagulation system
Primer Products
-
OriGene qPCR primer pairs for FCGR2C
-
OriGene qPCR primer pairs and template standards for FCGR2C
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for FCGR2C Gene
Orthologs for FCGR2C Gene
No data available for Orthologs for FCGR2C Gene
Paralogs for FCGR2C Gene
Paralogs for FCGR2C Gene
(9) SIMAP similar genes for FCGR2C Gene using alignment to 2 proteins:
Variants for FCGR2C Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033311 | -- | 161,596,864(+) | AATAG(-/TCTC)TCTAA | intron-variant | |
| rs1000328761 | -- | 161,582,212(+) | CTGCA(C/T)CTGAT | intron-variant | |
| rs1000329538 | -- | 161,587,014(+) | ATTGC(C/T)CCCTT | intron-variant | |
| rs1000982202 | -- | 161,594,757(+) | AATAA(A/G)GGCTC | intron-variant | |
| rs1001013343 | -- | 161,595,212(+) | TACTT(C/T)ACTCT | intron-variant |
Relevant External Links for FCGR2C Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FCGR2C Gene
Disorders for FCGR2C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thrombocytopenic purpura, autoimmune |
|
|
Search FCGR2C in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FCGR2C
No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR2C Gene
Publications for FCGR2C Gene
- Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. (PMID: 2531080) Stuart S.G. … Mellman I. (EMBO J. 1989) 2 3 4 64
- SNPs of Fc-gamma receptor genes and chronic periodontitis. (PMID: 20439936) Chai L. … Leung W.K. (J. Dent. Res. 2010) 3 46 64
- Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern D.P. … Seielstad M. (Nat. Genet. 2010) 3 46 64
- Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B. (PMID: 19309690) Breunis W.B. … Kuijpers T.W. (Hum. Mutat. 2009) 3 22 64
- Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. (PMID: 9516136) Metes D. … Morel P.A. (Blood 1998) 3 4 64
Products for FCGR2C Gene
- R&D Systems Antibodies for FCGR2C (Fc gamma RIIC/CD32c)
- R&D Systems Proteins and Enzymes for FCGR2C (Fc gamma RIIC/CD32c)
- R&D Systems ELISAs and other biochemical assays for FCGR2C (Fc gamma RIIC/CD32c)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FCGR2C
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCGR2C
- Browse OriGene Inhibitory RNA Products For FCGR2C
- OriGene qPCR primer pairs and template standards for FCGR2C
- OriGene qPCR primer pairs for FCGR2C
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- OriGene ORF clones in human for FCGR2C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for FCGR2C in any vector
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- GenScript Custom overexpressing Cell Line Services for FCGR2C
- Browse GenScript CRISPR for FCGR2C
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Novus Biologicals lysates for FCGR2C
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FCGR2C: See all 192
- antibodies-online Kits for FCGR2C: See all 12
- antibodies-online Proteins for FCGR2C: See all 10
- Search antibodies-online for peptides
- GeneTex FCGR2C antibody for FCGR2C
- Search GeneTex for Proteins for FCGR2C
- ViGene Biosciences adenoviral particle packaged cDNA for FCGR2C gene
- ViGene Biosciences lentiviral particle packaged cDNA for FCGR2C gene
- ViGene Biosciences ready-to-package AAV shRNAs for FCGR2C gene
- Search ViGene Biosciences for FCGR2C
- Santa Cruz Biotechnology (SCBT) Antibodies for FCGR2C
- Search Santa Cruz Biotechnology (SCBT) for FCGR2C siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for FCGR2C CRISPR
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCGR2C
- VectorBuilder custom plasmid, inducible vectors for FCGR2C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCGR2C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCGR2C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
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- (44) GeneTests
- (45) HGMD
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- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
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- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (100) COMPARTMENTS
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- (104) Addgene
- (105) antibodies-online
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