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Aliases for FCGR2C Gene

Aliases for FCGR2C Gene

  • Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) (Gene/Pseudogene) 2 3
  • IgG Fc Receptor II-C 3 4
  • Fc-Gamma-RIIc 3 4
  • CDW32 3 4
  • IGFR2 3 4
  • CD32 3 4
  • FCG2 3 4
  • Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) 2
  • Immunoglobulin G Fc Receptor II-C 3
  • Fc Gamma Receptor IIC 3
  • Fc-Gamma RII-C 4
  • CD32 Antigen 4
  • FcRII-C 4
  • FCRIIC 3
  • CD32C 3

External Ids for FCGR2C Gene

Previous GeneCards Identifiers for FCGR2C Gene

  • GC01U990219
  • GC01P158364
  • GC01P159817

Summaries for FCGR2C Gene

Entrez Gene Summary for FCGR2C Gene

  • This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

GeneCards Summary for FCGR2C Gene

FCGR2C (Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with FCGR2C include thrombocytopenic purpura, autoimmune. Among its related pathways are Immune System and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include transmembrane signaling receptor activity and IgG binding.

UniProtKB/Swiss-Prot for FCGR2C Gene

  • Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2C Gene

Genomics for FCGR2C Gene

Regulatory Elements for FCGR2C Gene

Genomic Location for FCGR2C Gene

Chromosome:
1
Start:
161,581,339 bp from pter
End:
161,605,662 bp from pter
Size:
24,324 bases
Orientation:
Plus strand

Genomic View for FCGR2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FCGR2C Gene

Proteins for FCGR2C Gene

  • Protein details for FCGR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31995-FCG2C_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-c
    Protein Accession:
    P31995
    Secondary Accessions:
    • O00523
    • O00524
    • O00525

    Protein attributes for FCGR2C Gene

    Size:
    323 amino acids
    Molecular mass:
    35578 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA35643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2C Gene

    Alternative splice isoforms for FCGR2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2C Gene

Proteomics data for FCGR2C Gene at MOPED

Post-translational modifications for FCGR2C Gene

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.
  • Glycosylation at Asn 106, Asn 180, and Asn 187
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGR2C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FCGR2C (Fc gamma RIIC/CD32c)

No data available for DME Specific Peptides for FCGR2C Gene

Domains & Families for FCGR2C Gene

Gene Families for FCGR2C Gene

Protein Domains for FCGR2C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FCGR2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31995

UniProtKB/Swiss-Prot:

FCG2C_HUMAN :
  • Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation
Domain:
  • Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCGR2C: view

Function for FCGR2C Gene

Molecular function for FCGR2C Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 2C (see IGFCR),primarily expressed by cells of the myeloid lineage
UniProtKB/Swiss-Prot Function:
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells

Gene Ontology (GO) - Molecular Function for FCGR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 2531080
GO:0005515 protein binding IPI 17474147
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2C: view

Phenotypes for FCGR2C Gene

genes like me logo Genes that share phenotypes with FCGR2C: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGR2C Gene

Localization for FCGR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2C Gene

Isoform IIC4: Cytoplasm.
Isoform IIC3: Cell membrane; Single-pass type I membrane protein.
Isoform IIC2: Cell membrane; Single-pass type I membrane protein.
Isoform IIC1: Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for FCGR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane NAS 2531080
genes like me logo Genes that share ontologies with FCGR2C: view

No data available for Subcellular locations from COMPARTMENTS for FCGR2C Gene

Pathways & Interactions for FCGR2C Gene

genes like me logo Genes that share pathways with FCGR2C: view

Gene Ontology (GO) - Biological Process for FCGR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 2531080
GO:0007165 signal transduction NAS 2531080
genes like me logo Genes that share ontologies with FCGR2C: view

No data available for SIGNOR curated interactions for FCGR2C Gene

Drugs & Compounds for FCGR2C Gene

(27) Drugs for FCGR2C Gene - From: DrugBank, FDA Approved Drugs, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma Target 94,126
Abciximab Approved Pharma Target 63
Adalimumab Approved Pharma Target 411
Alefacept Approved, Withdrawn Pharma Target 40
alemtuzumab Approved, Investigational Pharma Target Therapeutic Antibodies 293
genes like me logo Genes that share compounds with FCGR2C: view

Transcripts for FCGR2C Gene

Unigene Clusters for FCGR2C Gene

Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR2C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2C Gene

No ASD Table

Relevant External Links for FCGR2C Gene

GeneLoc Exon Structure for
FCGR2C
ECgene alternative splicing isoforms for
FCGR2C

Expression for FCGR2C Gene

mRNA expression in normal human tissues for FCGR2C Gene

mRNA differential expression in normal tissues according to GTEx for FCGR2C Gene

This gene is overexpressed in Whole Blood (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FCGR2C Gene



SOURCE GeneReport for Unigene cluster for FCGR2C Gene Hs.656750

mRNA Expression by UniProt/SwissProt for FCGR2C Gene

P31995-FCG2C_HUMAN
Tissue specificity: Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells
genes like me logo Genes that share expression patterns with FCGR2C: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for FCGR2C Gene

Orthologs for FCGR2C Gene

Evolution for FCGR2C Gene

ENSEMBL:
Gene Tree for FCGR2C (if available)
TreeFam:
Gene Tree for FCGR2C (if available)

No data available for Orthologs for FCGR2C Gene

Paralogs for FCGR2C Gene

(9) SIMAP similar genes for FCGR2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FCGR2C: view

No data available for Paralogs for FCGR2C Gene

Variants for FCGR2C Gene

Sequence variations from dbSNP and Humsavar for FCGR2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs364313 -- 161,593,747(-) TATCA(C/T)CAGAT intron-variant
rs416415 -- 161,599,238(-) AATTT(C/T)CCAAA intron-variant
rs422670 -- 161,599,358(+) TTTGA(A/T)TTTTA intron-variant
rs430178 -- 161,599,629(-) GGTGG(C/G)TGCAG splice-acceptor-variant
rs521923 -- 161,597,295(+) AGAAA(A/G)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGR2C Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
dgv397n71 CNV Gain 21882294
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv22n16 CNV Deletion 17901297
dgv74e199 CNV Deletion 23128226
dgv85n67 CNV Loss 20364138
nsv819523 CNV Loss 19587683
nsv818489 CNV Gain 17921354
nsv517640 CNV Gain+Loss 19592680
dgv137e1 CNV Complex 17122850
dgv138e1 CNV Complex 17122850
nsv872498 CNV Gain 21882294
essv6858 CNV CNV 17122850
dgv139e1 CNV Complex 17122850
nsv514915 CNV Complex 21397061
nsv818500 CNV Gain 17921354
nsv442209 CNV CNV 18776908
nsv509546 CNV Insertion 20534489
dgv23n16 CNV Insertion 17901297
esv2507888 CNV Deletion 19546169
esv990743 CNV Loss 20482838
nsv821621 CNV Loss 15273396
dgv50e201 CNV Deletion 23290073
dgv75e199 CNV Deletion 23128226
dgv24n16 CNV Insertion 17901297
nsv825242 CNV Loss 20364138
esv3325 CNV Deletion 18987735
esv5752 CNV Loss 19470904

Relevant External Links for FCGR2C Gene

HapMap Linkage Disequilibrium report
FCGR2C
Human Gene Mutation Database (HGMD)
FCGR2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FCGR2C Gene

Disorders for FCGR2C Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCGR2C Gene - From: OMIM

Disorder Aliases PubMed IDs
thrombocytopenic purpura, autoimmune
  • thrombocytopenia due to platelet alloimmunization
- elite association

Relevant External Links for FCGR2C

Genetic Association Database (GAD)
FCGR2C
Human Genome Epidemiology (HuGE) Navigator
FCGR2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR2C
genes like me logo Genes that share disorders with FCGR2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR2C Gene

Publications for FCGR2C Gene

  1. Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B). (PMID: 19201911) Meknache N. … DaAron M. (J. Immunol. 2009) 23 67
  2. Stable isotope labeling by amino acids in cell culture and differential plasma membrane proteome quantitation identify new substrates for the MARCH9 transmembrane E3 ligase. (PMID: 19457934) HAPr S. … Lehner P.J. (Mol. Cell Proteomics 2009) 23 67
  3. The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease. (PMID: 19734236) Wenink M.H. … Radstake T.R. (J. Immunol. 2009) 23 67
  4. Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B. (PMID: 19309690) Breunis W.B. … Kuijpers T.W. (Hum. Mutat. 2009) 23 67
  5. Endothelial expression of Fc gamma receptor IIb in the full-term human placenta. (PMID: 16600368) Mishima T. … Takizawa T. (Placenta 2007) 23 67

Products for FCGR2C Gene

Sources for FCGR2C Gene

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