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Aliases for FCGR2C Gene

Aliases for FCGR2C Gene

  • Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene) 2 3 5
  • Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) 2 3
  • IgG Fc Receptor II-C 3 4
  • Fc-Gamma-RIIc 3 4
  • CDw32 3 4
  • IGFR2 3 4
  • FCG2 3 4
  • CD32 3 4
  • Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) (Gene/Pseudogene) 2
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C 3
  • Immunoglobulin G Fc Receptor II-C 3
  • Fc Gamma Receptor IIc 2
  • Fc Gamma Receptor IIC 3
  • Fc-Gamma RII-C 4
  • CD32 Antigen 4
  • FcRII-C 4
  • FCRIIC 3
  • CD32C 3

External Ids for FCGR2C Gene

Previous GeneCards Identifiers for FCGR2C Gene

  • GC01U990219
  • GC01P158364
  • GC01P159817

Summaries for FCGR2C Gene

Entrez Gene Summary for FCGR2C Gene

  • This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

GeneCards Summary for FCGR2C Gene

FCGR2C (Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with FCGR2C include Thrombocytopenic Purpura, Autoimmune. Among its related pathways are Toxoplasmosis and Role of phospholipids in phagocytosis. GO annotations related to this gene include transmembrane signaling receptor activity and IgG binding. An important paralog of this gene is FCGR2A.

UniProtKB/Swiss-Prot for FCGR2C Gene

  • Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2C Gene

Genomics for FCGR2C Gene

Regulatory Elements for FCGR2C Gene

Enhancers for FCGR2C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161539 1.7 Ensembl ENCODE dbSUPER 27.1 -39.5 -39544 4.8 CREB3L1 FEZF1 YY1 SLC30A9 ZNF263 SP3 TBX21 MEF2D ZNF610 GLIS1 FCGR2C DUSP12 FCGR2A FCRLB ATF6 RPS23P10 HSPA7 FCGR3B TRN-GTT1-1 FCGR3A
GH01G161560 1.6 Ensembl ENCODE dbSUPER 26.7 -19.3 -19339 2.8 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 FOS FCGR2C ATF6 DUSP12 FCRLB FCGR2A FCRLA FCGR2B HSPA7 RPS23P10 ENSG00000224515
GH01G161528 2 FANTOM5 Ensembl ENCODE dbSUPER 21 -50.2 -50180 4.7 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF143 ZNF207 FOS FCGR2C FCGR2A DUSP12 FCRLA ATF6 FCGR2B HSPA6 FCGR3B RPS23P10 ARHGAP30
GH01G161554 1.5 Ensembl ENCODE dbSUPER 23.2 -26.2 -26228 1.8 PKNOX1 ARNT ARID4B SIN3A ZNF48 ZNF2 GLIS2 KLF13 ZNF202 REST FCGR2C HSPA7 ENSG00000224515 FCGR3A
GH01G161611 2 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +31.0 30962 2.6 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 KLF13 FCGR2B ATF6 FCGR2C FCGR3B DUSP12 HSPA6 HSPA7 FCRLB FCGR3A GC01P161612
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCGR2C on UCSC Golden Path with GeneCards custom track

Genomic Location for FCGR2C Gene

Chromosome:
1
Start:
161,581,339 bp from pter
End:
161,605,662 bp from pter
Size:
24,324 bases
Orientation:
Plus strand

Genomic View for FCGR2C Gene

Genes around FCGR2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR2C Gene

Proteins for FCGR2C Gene

  • Protein details for FCGR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31995-FCG2C_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-c
    Protein Accession:
    P31995
    Secondary Accessions:
    • O00523
    • O00524
    • O00525

    Protein attributes for FCGR2C Gene

    Size:
    323 amino acids
    Molecular mass:
    35578 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA35643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2C Gene

    Alternative splice isoforms for FCGR2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2C Gene

Post-translational modifications for FCGR2C Gene

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.
  • Glycosylation at Asn106, Asn180, and isoforms=2, 3, 4187
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGR2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCGR2C Gene

Domains & Families for FCGR2C Gene

Gene Families for FCGR2C Gene

Protein Domains for FCGR2C Gene

Suggested Antigen Peptide Sequences for FCGR2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31995

UniProtKB/Swiss-Prot:

FCG2C_HUMAN :
  • Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.
Domain:
  • Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.
genes like me logo Genes that share domains with FCGR2C: view

Function for FCGR2C Gene

Molecular function for FCGR2C Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 2C (see IGFCR),primarily expressed by cells of the myeloid lineage
UniProtKB/Swiss-Prot Function:
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Gene Ontology (GO) - Molecular Function for FCGR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 2531080
GO:0005515 protein binding IPI 17474147
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2C: view
genes like me logo Genes that share phenotypes with FCGR2C: view

Human Phenotype Ontology for FCGR2C Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGR2C Gene

Localization for FCGR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2C Gene

Isoform IIC4: Cytoplasm.
Isoform IIC3: Cell membrane; Single-pass type I membrane protein.
Isoform IIC2: Cell membrane; Single-pass type I membrane protein.
Isoform IIC1: Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for FCGR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 2531080
genes like me logo Genes that share ontologies with FCGR2C: view

No data available for Subcellular locations from COMPARTMENTS for FCGR2C Gene

Pathways & Interactions for FCGR2C Gene

genes like me logo Genes that share pathways with FCGR2C: view

Pathways by source for FCGR2C Gene

Interacting Proteins for FCGR2C Gene

Gene Ontology (GO) - Biological Process for FCGR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 2531080
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with FCGR2C: view

No data available for SIGNOR curated interactions for FCGR2C Gene

Drugs & Compounds for FCGR2C Gene

(29) Drugs for FCGR2C Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abciximab Approved Pharma Target 65
Adalimumab Approved Pharma Target 494
Alefacept Approved, Withdrawn Pharma Target 40
alemtuzumab Approved, Investigational Pharma Target Therapeutic Antibodies 310
Basiliximab Approved, Investigational Pharma Target 138
genes like me logo Genes that share compounds with FCGR2C: view

Transcripts for FCGR2C Gene

Unigene Clusters for FCGR2C Gene

Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2C Gene

No ASD Table

Relevant External Links for FCGR2C Gene

GeneLoc Exon Structure for
FCGR2C
ECgene alternative splicing isoforms for
FCGR2C

Expression for FCGR2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCGR2C Gene

mRNA differential expression in normal tissues according to GTEx for FCGR2C Gene

This gene is overexpressed in Whole Blood (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FCGR2C Gene



NURSA nuclear receptor signaling pathways regulating expression of FCGR2C Gene:

FCGR2C

SOURCE GeneReport for Unigene cluster for FCGR2C Gene:

Hs.656750

mRNA Expression by UniProt/SwissProt for FCGR2C Gene:

P31995-FCG2C_HUMAN
Tissue specificity: Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.

Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR2C Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
Organs:
General:
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with FCGR2C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for FCGR2C Gene

Orthologs for FCGR2C Gene

Evolution for FCGR2C Gene

ENSEMBL:
Gene Tree for FCGR2C (if available)
TreeFam:
Gene Tree for FCGR2C (if available)

No data available for Orthologs for FCGR2C Gene

Paralogs for FCGR2C Gene

(9) SIMAP similar genes for FCGR2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FCGR2C: view

Variants for FCGR2C Gene

Sequence variations from dbSNP and Humsavar for FCGR2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000033311 -- 161,596,864(+) AATAG(-/TCTC)TCTAA intron-variant
rs1000328761 -- 161,582,212(+) CTGCA(C/T)CTGAT intron-variant
rs1000329538 -- 161,587,014(+) ATTGC(C/T)CCCTT intron-variant
rs1000982202 -- 161,594,757(+) AATAA(A/G)GGCTC intron-variant
rs1001013343 -- 161,595,212(+) TACTT(C/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGR2C Gene

Variant ID Type Subtype PubMed ID
dgv22n16 CNV deletion 17901297
dgv23n16 CNV insertion 17901297
dgv24n16 CNV insertion 17901297
dgv38e201 CNV deletion 23290073
dgv447n100 CNV gain 25217958
dgv448n100 CNV loss 25217958
dgv449n100 CNV gain+loss 25217958
dgv450n100 CNV gain 25217958
dgv451n100 CNV loss 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv605n54 CNV loss 21841781
dgv606n54 CNV loss 21841781
dgv607n54 CNV loss 21841781
dgv74e199 CNV deletion 23128226
dgv75e199 CNV deletion 23128226
dgv85n67 CNV loss 20364138
dgv8e55 CNV gain 17911159
esv2507888 CNV deletion 19546169
esv2718873 CNV deletion 23290073
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv3325 CNV loss 18987735
esv33393 CNV gain+loss 17666407
esv3541689 CNV deletion 23714750
esv3584532 CNV gain 24956385
esv3587731 CNV loss 21293372
esv3587732 CNV loss 21293372
esv3587733 CNV gain 21293372
esv3890693 CNV loss 25118596
esv5752 CNV loss 19470904
esv990743 CNV loss 20482838
esv997087 CNV loss 20482838
nsv1112219 CNV deletion 24896259
nsv1161862 CNV duplication 26073780
nsv428257 CNV loss 18775914
nsv442209 CNV gain 18776908
nsv464173 CNV gain 19166990
nsv509546 CNV insertion 20534489
nsv514915 CNV gain 21397061
nsv517640 CNV gain+loss 19592680
nsv519779 CNV loss 19592680
nsv548066 CNV gain 21841781
nsv818489 CNV gain 17921354
nsv818500 CNV gain 17921354
nsv819523 CNV loss 19587683
nsv820341 CNV duplication 20802225
nsv821621 CNV loss 15273396
nsv825176 CNV gain 20364138
nsv825242 CNV loss 20364138
nsv8502 CNV loss 18304495
nsv946466 CNV duplication 23825009
nsv946467 CNV duplication 23825009
nsv946468 CNV duplication 23825009

Relevant External Links for FCGR2C Gene

Human Gene Mutation Database (HGMD)
FCGR2C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGR2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FCGR2C Gene

Disorders for FCGR2C Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCGR2C Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
thrombocytopenic purpura, autoimmune
  • thrombocytopenia due to platelet alloimmunization
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FCGR2C

Genetic Association Database (GAD)
FCGR2C
Human Genome Epidemiology (HuGE) Navigator
FCGR2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR2C
genes like me logo Genes that share disorders with FCGR2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR2C Gene

Publications for FCGR2C Gene

  1. Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. (PMID: 2531080) Stuart S.G. … Mellman I. (EMBO J. 1989) 2 3 4 64
  2. SNPs of Fc-gamma receptor genes and chronic periodontitis. (PMID: 20439936) Chai L. … Leung W.K. (J. Dent. Res. 2010) 3 46 64
  3. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern D.P. … Seielstad M. (Nat. Genet. 2010) 3 46 64
  4. Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B. (PMID: 19309690) Breunis W.B. … Kuijpers T.W. (Hum. Mutat. 2009) 3 22 64
  5. Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. (PMID: 9516136) Metes D. … Morel P.A. (Blood 1998) 3 4 64

Products for FCGR2C Gene

Sources for FCGR2C Gene

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