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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCGR2B Gene

protein-coding   GIFtS: 66
GCID: GC01P161552

Fc fragment of IgG, low affinity IIb, receptor (CD32)

(Previous names: Fc fragment of IgG, low affinity IIb, receptor for (CD32)...)
(Previous symbols: FCG2, FCGR2)
 Explore 38 diseases affiliated with
FCGR2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FCGR2B    

Aliases
for FCGR2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32)1 2     IGFR22 3
CD321 2 3 5     Fc Fragment Of IgG, Low Affinity II, Receptor For (CD32)2
FCG21 2 3     Fc Gamma RIIb2
CD32B1 2     Fc-Gamma-RIIb1
FCGR21 2     FcRII-B1
Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32)1 2     Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B2
Fc-Gamma RII-B2 3     Fc-Gamma-RIIb1
IgG Fc Receptor II-B2 3     FcRII-B1
CDw322 3     CD32 Antigen3

External Ids:    HGNC: 36181   Entrez Gene: 22132   Ensembl: ENSG000000726947   OMIM: 6045905   UniProtKB: P319943   

Export aliases for FCGR2B gene to outside databases

Previous GC identifers: GC01P159267 GC01P157283 GC01P158328 GC01P158820 GC01P158365 GC01P159899 GC01P132877


Summaries
for FCGR2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FCGR2B:
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The
encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by
B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
Function: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved
in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody
production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation
triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to
mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis

Gene Wiki entry for FCGR2B


Genomic Views
for FCGR2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCGR2B gene promoter:
         STAT5B   STAT1   AML1a   STAT1beta   STAT1alpha   E47   AREB6   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCGR2B promoter sequence
   Search SABiosciences Chromatin IP Primers for FCGR2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

FCGR2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161552:  view genomic region     (about GC identifiers)

Start:
 161,551,101 bp from pter      End:
 161,648,444 bp from pter
Size:
 97,344 bases      Orientation:
 plus strand

Proteins
for FCGR2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994 (See protein sequence)
Recommended Name: Low affinity immunoglobulin gamma Fc region receptor II-b precursor  
Size: 310 amino acids; 34044 Da
Subunit: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of
measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1.
Interacts with FGR. Interacts with LYN
Subcellular location: Cell membrane; Single-pass type I membrane protein
Caution: Has sometimes been attributed to correspond to FcR-IIC
Sequence caution: Sequence=CAA35645.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for FCGR2B:
2FCB (3D)    
Secondary accessions: A6H8N3 O95649 Q53X85 Q5VXA9 Q8NIA1
Alternative splicing: 3 isoforms:  P31994-1   P31994-2   P31994-3   

Explore the universe of human proteins at neXtProt for FCGR2B: NX_P31994

Post-translational modifications:

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31994

    • FCGR2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001002273.1  NP_001002274.1  NP_001002275.1  NP_001177757.1  NP_003992.3  

    ENSEMBL proteins: 
     ENSP00000236937   ENSP00000356938   ENSP00000351497   ENSP00000356939   ENSP00000356937  
     ENSP00000386038   ENSP00000404329  
    Reactome Protein details: P31994
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCGR2B (Fc gamma RIIB/C (CD32b/c), Fc gamma RIIB/CD32b)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): FCGR2B
    OriGene Protein Over-expression Lysate (see all 4): FCGR2B
    OriGene Custom Protein Services for FCGR2B 
    GenScript Custom Purified and Recombinant Proteins Services for FCGR2B
    Novus Biologicals FCGR2B Proteins
    Novus Biologicals FCGR2B Lysates
    Sino Biological Recombinant Protein for FCGR2B
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FCGR2B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    FCGR2B for ontologies           About GeneDecksing



    FCGR2B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FCGR2B
    R&D Systems Antibodies for FCGR2B (Fc gamma RIIB/C (CD32b/c), Fc gamma RIIB/CD32b)
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    GenScript Custom Superior Antibodies Services for FCGR2B
    Novus Biologicals FCGR2B Antibodies
    Abcam antibodies for FCGR2B 
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    ThermoFisher Antibodies for FCGR2B

    Assay Products for FCGR2B: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for FCGR2B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FCGR2B

    Protein Domains /
    Families
    for FCGR2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FCGR2B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P31994

    ProtoNet protein and cluster: P31994

    UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif
    (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2
    domain of several SH2-containing phosphatases
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for FCGR2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
    Function: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved
    in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody
    production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation
    triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to
    mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis

         Genatlas biochemistry entry for FCGR2B:
    immunoglobulin G,low affinity Fc receptor 2B (see IGFCR@2),maintaining gamma immune system homeostasis through negative
    regulation of immune responses mediated by receptors that bear the I,dysregulated by chromosomal translocation in
    malignant lymphoma

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): FCGR2B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCGR2B
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate FCGR2B (see all 18):
    hsa-miR-548j hsa-miR-4328 hsa-miR-548i hsa-miR-340 hsa-miR-3658 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: FCGR2B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCGR2B (see all 4)
    OriGene shRNA RFP: FCGR2B
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCGR2B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FCGR2B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2B (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2B (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): FCGR2B (NM_004001)
    Sino Biological Human cDNA Clone for FCGR2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2B 

    Cell Line
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    Search LifeMap BioReagents cell lines for FCGR2B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2B

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI17474147
    GO:0019864IgG binding IEA--


    FCGR2B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for FCGR2B: Fcgr2btm1.2Sjv Fcgr2btm1Ttk
         15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fcgr2b) (see all 16):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  respiratory system 

    FCGR2B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FCGR2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    		PI3K Signaling in B-Lymphocyte0.35
    		BCR signaling pathway0.41
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Immune response BCR pathway
    		Immune response BCR pathway1.00
    		Immune response_BCR pathway0.99
    4Fc-GammaR Pathway
    		Fc-GammaR Pathway1.00
    		Fc-Gamma-RIIB Signaling in B-Cells0.55
    5B Cell Receptor Signaling Pathway
    		B Cell Receptor Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FCGR2B
        Immune response BCR pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FCGR2B
        Fc-Gamma-RIIB Signaling in B-Cells
    Fc-GammaR Pathway
    Phospholipase-C Pathway
    PI3K Signaling in B-Lymphocyte

    1 GeneGo (Thomson Reuters) Pathway for FCGR2B
        Immune response BCR pathway

    3 BioSystems Pathways for FCGR2B 
        B Cell Receptor Signaling Pathway
    BCR signaling pathway
    Fc-epsilon receptor I signaling in mast cells

    3        Reactome Pathways for FCGR2B
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    5/8         Kegg Pathways  (Kegg details for FCGR2B) (see all 8):
        Phagosome
    Osteoclast differentiation
    B cell receptor signaling pathway
    Fc gamma R-mediated phagocytosis
    Staphylococcus aureus infection


    FCGR2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCGR2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/23 Interacting proteins for FCGR2B (P319941, 2, 3 ENSP000003514974) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 2, 3, ENSP000002440074EBI-724784,EBI-79387 MINT-8112519 I2D: score=3 STRING: ENSP00000244007
    FYNP062412, 3, ENSP000003576564MINT-8111187 I2D: score=3 STRING: ENSP00000357656
    PTPN11Q061242, 3, ENSP000003409444MINT-8025712 I2D: score=2 STRING: ENSP00000340944
    SHC1P293532, 3, ENSP000004013034MINT-8025701 I2D: score=2 STRING: ENSP00000401303
    C14orf1Q9UKR52, 3MINT-63666 I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS2142460
    GO:0007165signal transduction TAS2142460
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----
    GO:0050776regulation of immune response TAS--


    FCGR2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for FCGR2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCGR2B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCGR2B

    10/20 DrugBank Compounds for FCGR2B (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    Abciximab7E3 antibody (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Alemtuzumab-- 216503-57-0target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    CetuximabAnti EGFR (see all 2)205923-56-4target--17139284 17016423
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423

    10/15 Novoseek chemical compound relationships for FCGR2B gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 66.8 15 16406061 (3), 9973396 (2), 12773515 (2), 15081531 (1) (see all 8)
    tyrosine 55 44 16406061 (3), 11359765 (3), 10397152 (3), 11099496 (2) (see all 19)
    phosphatidylinositol 32.7 4 10397152 (2), 11709085 (1), 11035084 (1)
    ivig 32.2 13 15572393 (4), 12209098 (3), 19261857 (2), 8245176 (1)
    histamine 15.3 2 16499637 (2)
    calcium 12.1 9 8107887 (2), 15773572 (1), 11493628 (1), 9464844 (1) (see all 6)
    fitc 9.54 3 17133580 (1), 1374778 (1)
    fmlp 8.47 5 8656040 (5)
    dextran 1.04 2 1374778 (2)
    superoxide 1.02 2 8656040 (1), 9464844 (1)

    Search CenterWatch for drugs/clinical trials and news about FCGR2B / FCG2B 

    Transcripts
    for FCGR2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FCGR2B gene (5 alternative transcripts): 
    NM_001002273.2  NM_001002274.2  NM_001002275.2  NM_001190828.1  NM_004001.4  

    Unigene Cluster for FCGR2B:

    Fc fragment of IgG, low affinity IIb, receptor (CD32)
    Hs.654395  [show with all ESTs]
    Unigene Representative Sequence: AB209585
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236937(uc009wum.2) ENST00000367961 ENST00000358671(uc001gay.2 uc001gaz.2 uc001gba.2 uc009wun.2 uc001gbb.2)
    ENST00000480308 ENST00000485778 ENST00000367962 ENST00000367960 ENST00000403078
    ENST00000428605

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCGR2B
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate FCGR2B (see all 18):
    hsa-miR-548j hsa-miR-4328 hsa-miR-548i hsa-miR-340 hsa-miR-3658 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: FCGR2B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCGR2B (see all 4)
    OriGene shRNA RFP: FCGR2B
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCGR2B
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): FCGR2B (NM_004001)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCGR2B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCGR2B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGR2B

    Additional cDNA sequence: 

    AB050934.1 AB051387.1 AB209585.1 AF543826.1 AK308150.1 BC031992.1 BC141826.1 BC146678.1 
    BC148273.1 CR407635.1 M28696.1 M31933.1 M31934.1 M31935.1 U87560.1 U87561.1 
    U87562.1 U87563.1 U87564.1 U87565.1 U87566.1 U87567.1 U87568.1 U87569.1 
    U87570.1 U87571.1 U87572.1 U87573.1 U87574.1 U87575.1 U87576.1 U87577.1 
    X17653.1 X52473.1 X62573.1 

    12 DOTS entries:

    DT.100819780  DT.97844845  DT.100819781  DT.92449424  DT.100650618  DT.121462522  DT.100819779  DT.95156067 
    DT.95156075  DT.95156080  DT.87077467  DT.92449423 

    24/509 AceView cDNA sequences (see all 509):

    CR590408 BG057826 CA306625 BM681459 CR610288 NM_001002273 CR608780 U87562 
    AW452813 BX952560 NM_004001 CR611092 BM710444 BI019743 AA634109 BE645244 
    AI057418 CR593693 BC019931 NM_001002274 BX335112 CR593871 BU634221 T29511 

    GeneLoc Exon Structure


    Expression
    for FCGR2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCGR2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATCTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FCGR2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCGR2B

    SOURCE GeneReport for Unigene cluster: Hs.654395

    UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
    Tissue specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages,
    basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in
    natural killer cells

        SABiosciences Expression via Pathway-Focused PCR Array including FCGR2B: 
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for FCGR2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FCGR2B gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 --
    		 18(a)
    		 1 → many
    		 25(1707231-1709870)


    ENSEMBL Gene Tree for FCGR2B (if available)
    TreeFam Gene Tree for FCGR2B (if available) 

    Paralogs
    for FCGR2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCGR2B gene
    FCGR1B2  FCGR3B2  FCRL22  FCRLB2  FCRL12  FCRL42  FCRL52  FCRLA2  
    FCGR1A2  FCGR2A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    14 SIMAP similar genes for FCGR2B using alignment to 4 protein entries:     FCG2B_HUMAN (see all proteins):
    FCGR2C    FCGR2A    FCGR3B    Fc-gamma receptor IIIB    FCGR3A    FCGR1B
    FCGR1C    FCGR1A    FCRL5    CD22    FCRL3    FCER1A
    SIGLEC1    FCRLB

    FCGR2B for paralogs           About GeneDecksing



    Genomic Variants
    for FCGR2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
    Polymorphism: Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]


    10/340 NCBI SNPs in FCGR2B are shown (see all 340)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10505011,2
    		C,F,A,H,pathogenic147114431(+) TGGGAT/CTGCTG 10 /T /I mis1 ese36Minor allele frequency- C:0.14MN NA 408
    rs66975321,2
    		C,A--132875523(+) aggaaG/Caaaga 5 -- us2k11Minor allele frequency- C:0.00NA 2
    rs120429841,2
    		A--132875632(+) gaaagA/Gaagaa 5 -- us2k1 trp30--------
    rs120429871,2
    		A--132875641(+) aaagaA/Gagaga 5 -- us2k1 trp30--------
    rs23338421,2
    		C,O,A--132875981(+) aGTAAG/CAATTC 5 -- us2k11Minor allele frequency- C:0.00NA 2
    rs20077631,2
    		C,A,H--132883172(+) ATTGCC/TCCCTT 5 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs579723571,2
    		--132883538(+) TCTAAC/TAGCAA 5 -- int10--------
    rs46570861,2
    		C,F,A,H,--132883849(+) aacctG/Aggagg 5 -- int12Minor allele frequency- A:0.50NA WA 4
    rs17715521,2
    		C,A,H--132883934(+) aaaatA/Gaaata 5 -- int11Minor allele frequency- G:0.00NA 2
    rs762732161,2
    		C--132884013(+) GTGAAA/GAATCA 5 -- int10--------

    HapMap Linkage Disequilibrium report for FCGR2B (161551101 - 161648444 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 15 variations for FCGR2B
         15 CNVs: 6791 60899 48149 9375 43697 2329 65090 74759 4258 38950 1339 84629 8335 31666 65089
    Human Gene Mutation Database (HGMD): FCGR2B

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FCGR2B

    Disorders / Diseases
    for FCGR2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FCGR2B for disorders           About GeneDecksing

    OMIM gene information: 604590   
    OMIM disorders: 152700  611162  
    UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
  • Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation
    • t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor
    progression
  • Defects in FCGR2B are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. A chronic,
    • relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by
    involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent
    a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system
    dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow

    20/38 diseases for FCGR2B (see all 38):    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    diffuse large b-cell lymphoma    chronic inflammatory demyelinating polyneuropathy
    demyelinating polyneuropathy    microscopic polyangiitis    lichen planus    b-cell lymphomas
    common variable immunodeficiency    dengue hemorrhagic fever    oral lichen planus    hemorrhagic fever
    systemic lupus erythematosus, association with    polyneuropathy    burkitt's lymphoma    rheumatoid arthritis
    chronic polyneuropathy    lupus nephritis    follicular lymphoma    thrombocytopenia

    2 diseases from the University of Copenhagen DISEASES database for FCGR2B:
    Systemic lupus erythematosus     Chronic polyneuropathy

    10/17 Novoseek disease relationships for FCGR2B gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 57.6 15 17133600 (2), 8281338 (2), 17312177 (2), 17322888 (1) (see all 10)
    autoimmune diseases 49.2 8 15895258 (2), 15194165 (1), 19261857 (1), 17312177 (1) (see all 6)
    autoimmunity 48.5 12 20414206 (2), 17312177 (2), 10755621 (1), 15153544 (1) (see all 9)
    rheumatoid arthritis 31.1 4 17133580 (2), 15593228 (1), 17521421 (1)
    burkitt lymphoma 30.2 2 10397152 (1), 10382761 (1)
    mastocytoma 29.3 2 8683114 (1), 12217398 (1)
    lymphoma b-cell 17.1 4 14675408 (1), 11576217 (1), 15470484 (1), 16757681 (1)
    inflammation 12.4 7 17521421 (2), 11741917 (1), 19734236 (1), 16244114 (1)
    lymphoma follicular 12.1 2 10618414 (1), 14675408 (1)
    lymphoma 5.63 3 10618414 (1), 8683114 (1), 14675408 (1)

    Genetic Association Database (GAD): FCGR2B
    Human Genome Epidemiology (HuGE) Navigator: FCGR2B (41 documents)

    Export disorders for FCGR2B gene to outside databases

    Publications
    for FCGR2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCGR2B gene, integrated from 9 sources (see all 289):
    (articles sorted by number of sources associating them with FCGR2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. (PubMed id 12115230)1, 2, 4 Kyogoku C.... Tokunaga K. (2002)
    2. FcgammaRIIB gene polymorphisms in Japanese periodontitis patients. (PubMed id 14647193)1, 4, 9 Yasuda K....Yoshie H. (2003)
    3. Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis. (PubMed id 12858454)1, 4, 9 Tsuchiya N....Hashimoto H. (2003)
    4. A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythemato sus. (PubMed id 20385827)1, 2 Willcocks L.C....Smith K.G. (2010)
    5. Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria. (PubMed id 17435165)1, 2 Clatworthy M.R....Smith K.G. (2007)
    6. Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B. (PubMed id 16356189)1, 4 Morgan A.W....Isaacs J.D. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Ethnic variation of Fc gamma receptor polymorphism in Sami and Norwegian populations. (PubMed id 15946259)1, 4 Torkildsen O....Myhr K.M. (2005)
    9. Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from Asia. (PubMed id 16227149)1, 4 Tsuchiya N. and Kyogoku C. (2005)
    10. Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively. (PubMed id 15914856)1, 2 Laine D.... Valentin H. (2005)

    External Searches for FCGR2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing FCGR2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2213 HGNC: 3618 AceView: HSPA6andFCGR2A Ensembl:ENSG00000072694 euGenes: HUgn2213
    ECgene: FCGR2B Kegg: 2213 H-InvDB: FCGR2B

    Other Databases showing FCGR2B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FCGR2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCGR2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FCGR2B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FCGR2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FCGR2B gene:
    Search GeneIP for patents involving FCGR2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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