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FCGR2B Gene

protein-coding   GIFtS: 65
GCID: GC01P161552

Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32)

(Previous names: Fc fragment of IgG, low affinity IIb, receptor for (CD32))
(Previous symbols: FCG2, FCGR2)
  See FCGR2B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32)1 2     CD32B2
FCG21 2 3     Fc Fragment Of IgG, Low Affinity II, Receptor For (CD32)2
CD322 3 5     Fc Gamma RIIb2
FCGR21 2     fc-gamma-RIIb2
Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32)1 2     fcRII-b2
Fc-Gamma RII-B2 3     Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B2
IgG Fc Receptor II-B2 3     Fc-gamma-RIIb3
CDw322 3     FcRII-b3
IGFR22 3     CD32 Antigen3

External Ids:    HGNC: 36181   Entrez Gene: 22132   Ensembl: ENSG000000726947   OMIM: 6045905   UniProtKB: P319943   

Export aliases for FCGR2B gene to outside databases

Previous GC identifers: GC01P159267 GC01P157283 GC01P158328 GC01P158820 GC01P158365 GC01P159899 GC01P132877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCGR2B Gene:
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes.
The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody
production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE).
Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun
2010)

GeneCards Summary for FCGR2B Gene:
FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32)) is a protein-coding gene. Diseases associated with FCGR2B include chronic polyneuropathy, and multifocal motor neuropathy. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
Function: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor.
Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and
modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous
state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc
receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis

Gene Wiki entry for FCGR2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGR2B gene promoter:
         STAT5B   STAT1   AML1a   STAT1beta   STAT1alpha   E47   AREB6   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGR2B promoter sequence
   Search Chromatin IP Primers for FCGR2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

FCGR2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161552:  view genomic region     (about GC identifiers)

Start:
161,551,101 bp from pter      End:
161,648,444 bp from pter
Size:
97,344 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994 (See protein sequence)
Recommended Name: Low affinity immunoglobulin gamma Fc region receptor II-b precursor  
Size: 310 amino acids; 34044 Da
Subunit: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis
of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with
INPP5D/SHIP1. Interacts with FGR. Interacts with LYN
Caution: Has sometimes been attributed to correspond to FcR-IIC
Sequence caution: Sequence=CAA35645.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for FCGR2B:
2FCB (3D)        3WJJ (3D)    
Secondary accessions: A6H8N3 O95649 Q53X85 Q5VXA9 Q8NIA1
Alternative splicing: 3 isoforms:  P31994-1   P31994-2   P31994-3   

Explore the universe of human proteins at neXtProt for FCGR2B: NX_P31994

Explore proteomics data for FCGR2B at MOPED

Post-translational modifications: 

  • Phosphorylated by the SRC-type Tyr-kinases LYN and BLK1
  • Glycosylation2 at Asn106, Asn180, Asn187
  • Modification sites at PhosphoSitePlus

  • See FCGR2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001002273.1  NP_001002274.1  NP_001002275.1  NP_001177757.1  NP_003992.3  

    ENSEMBL proteins: 
     ENSP00000236937   ENSP00000356938   ENSP00000351497   ENSP00000356939   ENSP00000356937  
     ENSP00000386038   ENSP00000404329  
    Reactome Protein details: P31994

    FCGR2B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCGR2B (Fc gamma RIIB/C (CD32b/c), Fc gamma RIIB/CD32b)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FCGR2B
    OriGene Protein Over-expression Lysate for FCGR2B
    OriGene MassSpec for FCGR2B
    OriGene Custom Protein Services for FCGR2B
    GenScript Custom Purified and Recombinant Proteins Services for FCGR2B
    Novus Biologicals FCGR2B Proteins
    Novus Biologicals FCGR2B Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for FCGR2B
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FCGR2B 

    FCGR2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FCGR2B
    R&D Systems Antibodies for FCGR2B (Fc gamma RIIB/C (CD32b/c), Fc gamma RIIB/CD32b)
    OriGene Antibodies for FCGR2B
    OriGene Custom Antibody Services for FCGR2B
    Novus Biologicals FCGR2B Antibodies
    Abcam antibodies for FCGR2B (P31995, P31994, P12318)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for FCGR2B
    LSBio Antibodies in human, mouse, rat for FCGR2B

    FCGR2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FCGR2B
    R&D Systems ELISAs for FCGR2B (Fc gamma RIIB/C (CD32b/c), Fc gamma RIIB/CD32b)
    GenScript Custom Assay Services for FCGR2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FCGR2B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P31994

    ProtoNet protein and cluster: P31994

    UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCGR2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCG2B_HUMAN, P31994
    Function: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor.
    Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and
    modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous
    state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc
    receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis

         Genatlas biochemistry entry for FCGR2B:
    immunoglobulin G,low affinity Fc receptor 2B (see IGFCR@2),maintaining gamma immune system homeostasis through
    negative regulation of immune responses mediated by receptors that bear the I,dysregulated by chromosomal
    translocation in malignant lymphoma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10382761
    GO:0019864IgG binding IEA--
         
    Find genes that share ontologies with FCGR2B           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Fcgr2b) (see all 16):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  respiratory system 

    Find genes that share phenotypes with FCGR2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FCGR2B: Fcgr2btm1.2Sjv Fcgr2btm1.2Rav Fcgr2btm1Ttk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCGR2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCGR2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCGR2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCGR2B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FCGR2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FCGR2B (see all 18):
    hsa-miR-548j hsa-miR-4328 hsa-miR-548i hsa-miR-340 hsa-miR-3658 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidFCGR2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FCGR2B
    Predesigned siRNA for gene silencing in human, mouse, rat FCGR2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCGR2B

    Clone
    Products:
         
    OriGene clones in human, mouse for FCGR2B (see all 26)
    OriGene ORF clones in mouse, rat for FCGR2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): FCGR2B (NM_004001)
    Sino Biological Human cDNA Clone for FCGR2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCGR2B
    Browse ESI BIO Cell Lines and PureStem Progenitors for FCGR2B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCG2B_HUMAN, P31994: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FCGR2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCGR2B About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    2B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    3Fc-GammaR Pathway
    Fc-Gamma-RIIB Signaling in B-Cells0.55
    Fc-GammaR Pathway0.55
    4Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with FCGR2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FCGR2B
        Fc-Gamma-RIIB Signaling in B-Cells
    Fc-GammaR Pathway
    Phospholipase-C Pathway
    PI3K Signaling in B-Lymphocyte

    1 GeneGo (Thomson Reuters) Pathway for FCGR2B
        Immune response BCR pathway

    3 BioSystems Pathways for FCGR2B
        B Cell Receptor Signaling Pathway
    BCR signaling pathway
    Fc-epsilon receptor I signaling in mast cells


    1 Reactome Pathway for FCGR2B
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for FCGR2B) (see all 7):
        Phagosome
    Osteoclast differentiation
    B cell receptor signaling pathway
    Fc gamma R-mediated phagocytosis
    Staphylococcus aureus infection

        Pathway & Disease-focused RT2 Profiler PCR Array including FCGR2B: 
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FCGR2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for FCGR2B (P319941, 2, 3 ENSP000003514974) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 2, 3, ENSP000002440074EBI-724784,EBI-79387 MINT-8112519 I2D: score=3 STRING: ENSP00000244007
    FYNP062412, 3, ENSP000003576564MINT-8111187 I2D: score=3 STRING: ENSP00000357656
    PTPN11Q061242, 3, ENSP000003409444MINT-8025712 I2D: score=2 STRING: ENSP00000340944
    SHC1P293532, 3, ENSP000004013034MINT-8025701 I2D: score=2 STRING: ENSP00000401303
    C14orf1Q9UKR52, 3MINT-63666 I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS2142460
    GO:0007165signal transduction TAS2142460
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0050776regulation of immune response TAS--

    Find genes that share ontologies with FCGR2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGR2B (FCG2B)

    Selected DrugBank Compounds for FCGR2B (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    Abciximab7E3 (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Alemtuzumab-- 216503-57-0target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    CetuximabAnti EGFR (see all 2)205923-56-4target--17139284 17016423
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for FCGR2B gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 66.8 15 16406061 (3), 9973396 (2), 12773515 (2), 15081531 (1) (see all 8)
    tyrosine 55 44 16406061 (3), 11359765 (3), 10397152 (3), 11099496 (2) (see all 19)
    phosphatidylinositol 32.7 4 10397152 (2), 11709085 (1), 11035084 (1)
    ivig 32.2 13 15572393 (4), 12209098 (3), 19261857 (2), 8245176 (1)
    histamine 15.3 2 16499637 (2)
    calcium 12.1 9 8107887 (2), 15773572 (1), 11493628 (1), 9464844 (1) (see all 6)
    fitc 9.54 3 17133580 (1), 1374778 (1)
    fmlp 8.47 5 8656040 (5)
    dextran 1.04 2 1374778 (2)
    superoxide 1.02 2 8656040 (1), 9464844 (1)



    Find genes that share compounds with FCGR2B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCGR2B gene (5 alternative transcripts): 
    NM_001002273.2  NM_001002274.2  NM_001002275.2  NM_001190828.1  NM_004001.4  

    Unigene Cluster for FCGR2B:

    Fc fragment of IgG, low affinity IIb, receptor (CD32)
    Hs.654395  [show with all ESTs]
    Unigene Representative Sequence: AB209585
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236937(uc009wum.2) ENST00000367961 ENST00000358671(uc001gay.2 uc001gaz.2 uc001gba.2 uc009wun.2 uc001gbb.2)
    ENST00000480308 ENST00000485778 ENST00000367962 ENST00000367960 ENST00000403078
    ENST00000428605
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FCGR2B (see all 18):
    hsa-miR-548j hsa-miR-4328 hsa-miR-548i hsa-miR-340 hsa-miR-3658 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidFCGR2B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FCGR2B
    Predesigned siRNA for gene silencing in human, mouse, rat FCGR2B
    Clone
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    OriGene clones in human, mouse for FCGR2B (see all 26)
    OriGene ORF clones in mouse, rat for FCGR2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): FCGR2B (NM_004001)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FCGR2B
    OriGene qSTAR qPCR primer pairs in human, mouse for FCGR2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCGR2B
      QuantiTect SYBR Green Assays in human, mouse, rat FCGR2B
      QuantiFast Probe-based Assays in human, mouse, rat FCGR2B

    Additional mRNA sequence: 

    AB050934.1 AB051387.1 AB209585.1 AF543826.1 AK308150.1 BC031992.1 BC141826.1 BC146678.1 
    BC148273.1 CR407635.1 M28696.1 M31933.1 M31934.1 M31935.1 U87560.1 U87561.1 
    U87562.1 U87563.1 U87564.1 U87565.1 U87566.1 U87567.1 U87568.1 U87569.1 
    U87570.1 U87571.1 U87572.1 U87573.1 U87574.1 U87575.1 U87576.1 U87577.1 
    X17653.1 X52473.1 X62573.1 

    12 DOTS entries:

    DT.100819780  DT.97844845  DT.100819781  DT.92449424  DT.100650618  DT.121462522  DT.100819779  DT.95156067 
    DT.95156075  DT.95156080  DT.87077467  DT.92449423 

    Selected AceView cDNA sequences (see all 509):

    BF591739 CR624955 BQ718336 X51758 U87568 BM671898 BC031992 AB051387 
    CD368312 BU620984 BP346035 NM_001002274 CR607206 BU634221 U87564 NM_004001 
    BX118947 BC019931 NM_001002273 AB050934 BM978253 BG058778 R34695 BI019743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCGR2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATCTATA
    FCGR2B Expression
    About this image


    FCGR2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Kidney (Urinary System)
             Ureteric Bud
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    FCGR2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGR2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654395

    UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
    Tissue specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils,
    macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells).
    Not detected in natural killer cells

        Pathway & Disease-focused RT2 Profiler PCR Array including FCGR2B: 
              Cardiotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCGR2B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgr2b1 , 5 Fc receptor, IgG, low affinity IIb1, 5 74.17(n)1
    63.25(a)1
      1 (78.02 cM)5
    141301  NM_001077189.11  NP_001070657.11 
     1709605585 


    ENSEMBL Gene Tree for FCGR2B (if available)
    TreeFam Gene Tree for FCGR2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCGR2B gene
    FCGR1B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  FCRL42  
    FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    14 SIMAP similar genes for FCGR2B using alignment to 4 protein entries:     FCG2B_HUMAN (see all proteins):
    FCGR2C    FCGR2A    FCGR3B    Fc-gamma receptor IIIB    FCGR3A    FCGR1C
    FCGR1A    FCGR1B    FCRL5    CD22    FCRL3    FCER1A
    SIGLEC1    FCRLB

    Find genes that share paralogs with FCGR2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    FCG2B_HUMAN, P31994: Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]


    Selected SNPs for FCGR2B (see all 440)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10505011,2,,4
    C,F,A,Hpathogenic1168194543(+) TGGGAT/CTGCTG 10 /T /I mis1 ese36Minor allele frequency- C:0.14MN NA 408
    rs2007844341,2
    C--132875521(+) AAAGG-/AAGA  
            
    AAGAA
    5 -- us2k10--------
    rs66975321,2
    C,A--132875523(+) aggaaG/Caaaga 5 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1444957821,2
    C--132875551(+) GGAAGA/GAAGGA 5 -- us2k10--------
    rs1900176401,2
    --132875573(+) AAAGAA/CAGAAA 5 -- us2k10--------
    rs1814378951,2
    C--132875581(+) AAAGAA/GAGAAA 5 -- us2k10--------
    rs1893294751,2
    C--132875589(+) AAAGAA/GAGAAA 5 -- us2k10--------
    rs66867061,2
    A--132875616(+) aaagaA/Caggaa 5 -- us2k1 trp30--------
    rs23338421,2
    C,O,A--132875981(+) aGTAAG/CAATTC 5 -- us2k11Minor allele frequency- C:0.00NA 2
    rs562793181,2
    C--132883901(+) CCTGGG/-TGACA 5 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for FCGR2B (161551101 - 161648444 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCGR2B (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3325CNV Deletion18987735
    nsv820341CNV Duplication20802225
    dgv24n16CNV Insertion17901297
    nsv509546CNV Insertion20534489
    nsv821621CNV Loss15273396
    esv997087CNV Loss20482838
    nsv428257CNV Loss18775914
    dgv85n67CNV Loss20364138
    nsv8502CNV Loss18304495
    nsv437224CNV Loss16327808

    Human Gene Mutation Database (HGMD): FCGR2B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCGR2B
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGR2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604590   
    OMIM disorders: 152700  611162  
    UniProtKB/Swiss-Prot: FCG2B_HUMAN, P31994
  • Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation
    t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the
    tumor progression
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile
    multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints,
    kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory
    mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated
    erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 10 diseases for FCGR2B:    
    About MalaCards
    chronic polyneuropathy    multifocal motor neuropathy    systemic lupus erythematosus    chronic inflammatory demyelinating polyneuropathy
    malaria    microscopic polyangiitis    demyelinating polyneuropathy    cardiovascular disease risk factor
    polyneuropathy    lupus erythematosus

    3 diseases from the University of Copenhagen DISEASES database for FCGR2B:
    Lupus erythematosus     Connective tissue disease     Chronic polyneuropathy

    Find genes that share disorders with FCGR2B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FCGR2B gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 57.6 15 17133600 (2), 8281338 (2), 17312177 (2), 17322888 (1) (see all 10)
    autoimmune diseases 49.2 8 15895258 (2), 15194165 (1), 19261857 (1), 17312177 (1) (see all 6)
    autoimmunity 48.5 12 20414206 (2), 17312177 (2), 10755621 (1), 15153544 (1) (see all 9)
    rheumatoid arthritis 31.1 4 17133580 (2), 15593228 (1), 17521421 (1)
    burkitt lymphoma 30.2 2 10397152 (1), 10382761 (1)
    mastocytoma 29.3 2 8683114 (1), 12217398 (1)
    lymphoma b-cell 17.1 4 14675408 (1), 11576217 (1), 15470484 (1), 16757681 (1)
    inflammation 12.4 7 17521421 (2), 11741917 (1), 19734236 (1), 16244114 (1)
    lymphoma follicular 12.1 2 10618414 (1), 14675408 (1)
    lymphoma 5.63 3 10618414 (1), 8683114 (1), 14675408 (1)

    Genetic Association Database (GAD): FCGR2B
    Human Genome Epidemiology (HuGE) Navigator: FCGR2B (41 documents)

    Export disorders for FCGR2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCGR2B gene, integrated from 10 sources (see all 305):
    (articles sorted by number of sources associating them with FCGR2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. (PubMed id 20385827)1, 2, 4 Willcocks L.C.... Smith K.G. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    2. Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. (PubMed id 12115230)1, 2, 4 Kyogoku C.... Tokunaga K. (Arthritis Rheum. 2002)
    3. Genetic susceptibility and haplotype analysis between Fcgamma receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population. (PubMed id 18625651)1, 4, 9 Pan F....Ye D.Q. (Lupus 2008)
    4. The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis. (PubMed id 17133580)1, 4, 9 Radstake T.R....van Riel P.L. (Arthritis Rheum. 2006)
    5. FcgammaRIIB gene polymorphisms in Japanese periodontitis patients. (PubMed id 14647193)1, 4, 9 Yasuda K....Yoshie H. (Genes Immun. 2003)
    6. Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis. (PubMed id 17020818)1, 4, 9 Umemura T....Kiyosawa K. (Clin. Immunol. 2007)
    7. Association of Fcgamma receptor IIB gene polymorphism with genetic susceptibility to systemic lupus erythematosus in Chinese populations--a family-based association study. (PubMed id 16531013)1, 4, 9 Pan F....Ye D. (J. Dermatol. Sci. 2006)
    8. Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients. (PubMed id 17133600)1, 4, 9 Chen J.Y....Wu J. (Arthritis Rheum. 2006)
    9. The combined genotypes of stimulatory and inhibitory Fc gamma receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults. (PubMed id 17335370)1, 4, 9 Kobayashi T....Yoshie H. (J. Periodontol. 2007)
    10. Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis. (PubMed id 12858454)1, 4, 9 Tsuchiya N....Hashimoto H. (J. Rheumatol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2213 HGNC: 3618 AceView: HSPA6andFCGR2A Ensembl:ENSG00000072694 euGenes: HUgn2213
    ECgene: FCGR2B Kegg: 2213 H-InvDB: FCGR2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCGR2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FCGR2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCGR2B gene:
    Search GeneIP for patents involving FCGR2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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