FCGR2A Gene
protein-coding GIFtS: 64
GCID: GC01P161475
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|
Fc fragment of IgG, low affinity IIa, receptor (CD32)(Previous names: Fc fragment of IgG, low affinity IIa, receptor for (CD32)...)
(Previous symbols: FCG2, FCGR2A1, FCGR2)
| |
Aliases
for FCGR2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32)1 2 | | Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32)1 | | CD321 2 3 5 | | FcGR2 | | IGFR21 2 3 5 | | Fc-Gamma-RIIa1 | | CDw321 2 3 | | FcRII-A1 | | FCG21 2 3 | | Immunoglobulin G Fc Receptor II2 | | FCGR2A11 2 3 | | Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A2 | | CD32A1 2 | | Fc-Gamma-RIIa1 | | FCGR21 2 | | FcRII-A1 | | Fc-Gamma RII-A2 3 | | CD32 Antigen3 | | IgG Fc Receptor II-A2 3 | | |
Export aliases for FCGR2A gene to outside databasesPrevious GC identifers: GC01P159191 GC01P157207 GC01P158252 GC01P158744 GC01P158743 GC01P158288 GC01P159741 GC01P132800 |
Summaries
for FCGR2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FCGR2A:
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immuneresponse cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such asmacrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes.Alternative splicing results in multiple transcript variants. (provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiatescellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens
Gene Wiki entry for FCGR2A
|
Genomic Views
for FCGR2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCGR2A gene promoter:
TBP STAT1 p53 AML1a FOXD1 Evi-1 E47 STAT3 Hand1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCGR2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23FCGR2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P161475: view genomic region
(about GC identifiers)
Start:
|
161,475,205 bp from pter |
End:
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161,493,803 bp from pter |
Size:
|
18,599 bases |
Orientation:
|
plus strand |
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Proteins
for FCGR2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318 (See
protein sequence)Recommended Name: Low affinity immunoglobulin gamma Fc region receptor II-a precursor Size: 317 amino acids; 35001 Da
Subunit: Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interactswith HCK
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAA35932.1; Type=Erroneous initiation;
6 PDB 3D structures from  and Proteopedia  for FCGR2A:1FCG (3D)
1H9V (3D)
3D5O (3D)
3RY4 (3D)
3RY5 (3D)
3RY6 (3D)
Secondary accessions: Q8WUN1 Q8WW64Alternative splicing: 2 isoforms: P12318-1 P12318-2 Explore the universe of human proteins at neXtProt for FCGR2A: NX_P12318
Post-translational modifications:
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P12318
FCGR2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001129691.1 NP_067674.2
ENSEMBL proteins: ENSP00000356949 ENSP00000271450 ENSP00000441156 ENSP00000440148 ENSP00000438310 ENSP00000440082 Reactome Protein details: P12318
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FCGR2A for ontologies About GeneDecksing
FCGR2A Antibody Products:
Assay Products for FCGR2A: |
Protein
Domains /
Families
for FCGR2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCGR2A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P12318ProtoNet protein and cluster: P12318 UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for FCGR2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiatescellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens Genatlas biochemistry entry for FCGR2A:immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FCGR2A (NM_021642) | |  | Sino Biological Human cDNA Clone for FCGR2A | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCGR2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FCGR2A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FCGR2A:
Animal Models:
Mouse knock-outs for FCGR2A: Fcgr3tm1Ttk Fcgr3tm1Sjv
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fcgr3):
FCGR2A for phenotypes About GeneDecksing
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Pathways & Interactions
for FCGR2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of actin dynamics for phagocytic cup formation | | | 2 | Cleavage of Alpha-1-Microglobulin | | | 3 | Immune System | | | 4 | Selected targets of CREB1 | | | 5 | Phagocytosis of Microbes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for FCGR2A
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FCGR2A
1  BioSystems Pathway for FCGR2A
5/8 
Reactome Pathways for FCGR2A (see all 8)
5/7 
Kegg Pathways (Kegg details for FCGR2A) (see all 7):
FCGR2A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCGR2A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/37 Interacting proteins for FCGR2A (P123182, 3 ENSP000002714504) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
|
Drugs & Compounds
for FCGR2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FCGR2A for compounds About GeneDecksing
 Browse Tocris compounds for FCGR2A
10/19 DrugBank Compounds for FCGR2A (see all 19) About this table
10/39 Novoseek chemical compound relationships for FCGR2A gene (see all 39) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| r 131 |
83 |
6 |
15004265 (4), 19026120 (1) |
| piceatannol |
62.5 |
1 |
11344169 (1) |
| dihydrotachysterol |
59.6 |
1 |
1532752 (1) |
| tyrosine |
52.7 |
121 |
11141335 (4), 15130090 (4), 7521687 (4), 16169188 (3) (see all 43) |
| histidine |
48.7 |
23 |
8772237 (2), 10675363 (1), 18165525 (1), 8555090 (1) (see all 15) |
| arginine |
34.9 |
33 |
8772237 (3), 10675363 (1), 18165525 (1), 19232413 (1) (see all 15) |
| phenylalanine |
33.5 |
4 |
11719384 (1), 9382867 (1), 10449433 (1), 12508114 (1) |
| wortmannin |
28.7 |
1 |
12407113 (1) |
| rituximab |
28.2 |
8 |
17324336 (3), 17650444 (1), 14563637 (1), 17594928 (1) (see all 5) |
| inositol |
26.1 |
4 |
9525908 (1), 12773515 (1), 12832410 (1), 11741917 (1) |
Search CenterWatch for drugs/clinical trials and news about FCGR2A / FCG2A
|
Transcripts
for FCGR2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCGR2A gene (2 alternative transcripts): NM_001136219.1 NM_021642.3 Unigene Cluster for FCGR2A: Fc fragment of IgG, low affinity IIa, receptor (CD32) Hs.352642 [show with all ESTs]Unigene Representative Sequence: NM_00113621915 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367972 ENST00000271450(uc001gan.3 uc001gam.3 uc021pcz.1 uc021pda.1)
ENST00000467654 ENST00000473080 ENST00000536731 ENST00000483665 ENST00000497474
ENST00000482233 ENST00000467525 ENST00000471026 ENST00000537821 ENST00000461298
ENST00000459885 ENST00000486608 ENST00000491841
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FCGR2A (NM_021642) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCGR2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2A |
Additional cDNA sequence: AK225438.1 AK225601.1 AK226059.1 AK298657.1 AK298734.1 AK315225.1 BC019931.1 BC020823.1 J03619.1 M28697.1 M31932.1 X62572.1 Y00644.1 20 DOTS entries: DT.92449395 DT.97844847 DT.87077467 DT.121462482 DT.92449402 DT.95156082 DT.121462532 DT.121462586 DT.92449404 DT.92449423 DT.95360629 DT.100057430 DT.100774280 DT.121462502 DT.121462581 DT.121462594 DT.85104268 DT.87018412 DT.91650634 DT.91958909 24/509 AceView cDNA sequences (see all 509): BU634221 CR593871 CR610288 AW452813 BM681459 T29511 NM_021642 U87570 BE676071 CR607206 CR624955 BM671898 BQ718336 BC031992 BG435504 AB051387 U87561 U87569 CD367192 AI523174 BM717638 AI735695 BM978253 BF591739
GeneLoc Exon Structure
|
Expression
for FCGR2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCGR2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGTCTATA
About this image
See FCGR2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCGR2A
SOURCE GeneReport for Unigene cluster: Hs.352642
UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets
SABiosciences Expression via Pathway-Focused PCR Array including FCGR2A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCGR2A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCGR2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGR2A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2A |
Orthologs
for FCGR2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FCGR2A gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
-- |
18(a) |
1 → many |
25(1707231-1709870) |
ENSEMBL Gene Tree for FCGR2A (if available)
TreeFam Gene Tree for FCGR2A (if available) |
Paralogs
for FCGR2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCGR2A gene
- FCGR2B2 FCGR1B2 FCGR3B2 FCRL22 FCRLB2 FCRL12 FCRL42 FCRL52
- FCRLA2 FCGR1A2 FCGR3A2 FCRL32 FCER1A2 FCRL62
10 SIMAP similar genes for FCGR2A using alignment to 5 protein entries: FCG2A_HUMAN (see all proteins):FCGR2B FCGR2C FCGR3B Fc-gamma receptor IIIB FCGR3A FCGR1A
FCGR1B FCGR1C FCRLB FCER1A
FCGR2A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FCGR2A
PGOHUM00000258580
|
Genomic Variants
for FCGR2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCGR2A (161475205 - 161493803 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for FCGR2A
9 CNVs: 6791 3316 2329 65090 4258 8335 31666 65089 22934
Human Gene Mutation Database (HGMD): FCGR2A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCGR2A |
|
Disorders
/ Diseases
for FCGR2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCGR2A for disorders About GeneDecksing
OMIM gene information: 146790
OMIM disorders: --
20/108  diseases for FCGR2A (see all 108): About MalaCardsheparin-induced thrombocytopenia adult-onset still's disease diffuse large b-cell lymphoma guillain-barre syndrome
asymptomatic dengue otitis media microscopic polyangiitis graft versus host disease
lupus nephritis myasthenia gravis lichen planus b-cell lymphomas
plasmodium falciparum malaria dengue hemorrhagic fever oral lichen planus systemic lupus erythematosus
non-hodgkin lymphoma severe acute respiratory syndrome lupus erythematosus hemorrhagic fever
4 diseases from the University of Copenhagen DISEASES database for FCGR2A:Systemic lupus erythematosus Thrombocytopenia Nephritis Periodontitis 10/41 Novoseek disease relationships for FCGR2A gene (see all 41) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lupus erythematosus systemic |
63.1 |
21 |
11561111 (2), 12215902 (2), 10413210 (1), 12215903 (1) (see all 18) |
| nephritis |
59.5 |
8 |
15004265 (4), 11263776 (1), 11480843 (1) |
| lupus nephritis |
56.7 |
10 |
15004265 (3), 11237133 (2), 8636449 (2), 11229467 (1) (see all 6) |
| autoimmune diseases |
51.2 |
8 |
16200626 (2), 16221721 (1), 10882671 (1), 19030019 (1) (see all 7) |
| thrombocytopenia |
46.4 |
18 |
10201963 (3), 11480843 (2), 11434690 (1), 11588041 (1) (see all 13) |
| rheumatoid arthritis |
39.4 |
10 |
16221721 (1), 19030019 (1), 16084773 (1), 12734884 (1) (see all 8) |
| meningococcal diseases |
34.7 |
5 |
7930726 (1), 11812402 (1), 9798027 (1), 15243816 (1) |
| purpura thrombocytopenic |
33.8 |
3 |
18485087 (1) |
| malaria falciparum |
30.5 |
5 |
19284648 (2), 18194515 (1), 17587350 (1) |
| autoimmunity |
28.2 |
3 |
16200626 (2), 10675363 (1) |
Genetic Association Database (GAD): FCGR2A
Human Genome Epidemiology (HuGE) Navigator: FCGR2A (228 documents)
Export disorders for FCGR2A gene to outside databases
|
Publications
for FCGR2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCGR2A gene, integrated from 9 sources (see all 574):
(articles sorted by number of sources associating them with FCGR2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia. (PubMed id 15217834)1, 4, 7 Lin T.S....Byrd J.C. (2005)
- The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PubMed id 15457442)1, 4, 7 Criswell L.A....Bridges S.L. (2004)
- Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG. (PubMed id 10397151)1, 2, 9 Powell M.S.... Hogarth P.M. (1999)
- FcgammaRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients. (PubMed id 11480843)1, 4, 9 Yun H.R....Kim S.Y. (2001)
- The FcgammaRIIa polymorphism in children with atopic diseases. (PubMed id 14976391)1, 4, 9 Pawlik A....Gawronska-Szklarz B. (2004)
- FcgammaRIIa polymorphism in Japanese patients with systemic lupus erythematosus. (PubMed id 11237133)1, 4, 9 Sato H....Dohi K. (2001)
- Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PubMed id 17324336)1, 7, 9 Hatjiharissi E....Treon S.P. (2007)
- Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study. (PubMed id 15583733)1, 4, 9 van der Meer I.M....de Maat M.P. (2004)
- Platelet FcgammaRIIA His131Arg polymorphism and platelet function: antibodies to platelet-bound fibrinogen induce platelet activation. (PubMed id 12871511)1, 4, 9 Chen J....Bray P.F. (2003)
- Low-binding alleles of Fcgamma receptor types IIA and IIIA are inherited independently and are associated with systemic lupus erythematosus in Hispanic patients. (PubMed id 11229467)1, 4, 9 Zuniga R....Salmon J.E. (2001)
|
External Searches for FCGR2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FCGR2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing FCGR2A gene
(According to HUGE)
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Specialized Databases showing FCGR2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FCGR2A | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for FCGR2A gene:
Search GeneIP for patents involving FCGR2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FCGR2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for FCGR2A | | OriGene shRNA RFP for FCGR2A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCGR2A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCGR2A | | | OriGene Protein Over-expression Lysate for FCGR2A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FCGR2A | | OriGene 3'-UTR Clone for FCGR2A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FCGR2A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FCGR2A | | OriGene Custom Protein Services for FCGR2A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCGR2A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCGR2A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR2A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCGR2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGR2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR2A |
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| | | | Search Tocris compounds for FCGR2A |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2A |
|  |  |  | | | | ThermoFisher Antibodies for FCGR2A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2A |
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