Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FCGR2A Gene

protein-coding   GIFtS: 65
GCID: GC01P161475

Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32)

(Previous names: Fc fragment of IgG, low affinity IIa, receptor for (CD32))
(Previous symbols: FCG2, FCGR2A1, FCGR2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32)1 2     Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32)1
FCG21 2 3     CD32A2
FCGR2A11 2 3     FcGR2
CD322 3 5     fc-gamma-RIIa2
IGFR22 3 5     fcRII-a2
FCGR21 2     Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A2
Immunoglobulin G Fc Receptor II1 2     Fc-gamma-RIIa3
Fc-Gamma RII-A2 3     FcRII-a3
IgG Fc Receptor II-A2 3     CD32 Antigen3
CDw322 3     

External Ids:    HGNC: 36161   Entrez Gene: 22122   Ensembl: ENSG000001432267   OMIM: 1467905   UniProtKB: P123183   

Export aliases for FCGR2A gene to outside databases

Previous GC identifers: GC01P159191 GC01P157207 GC01P158252 GC01P158744 GC01P158743 GC01P158288 GC01P159741 GC01P132800


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FCGR2A Gene:
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune
response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as
macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Oct 2008)

GeneCards Summary for FCGR2A Gene:
FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)) is a protein-coding gene. Diseases associated with FCGR2A include lupus nephritis, and malaria, severe. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318
Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates
cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens

Gene Wiki entry for FCGR2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGR2A gene promoter:
         TBP   STAT1   p53   AML1a   FOXD1   Evi-1   E47   STAT3   Hand1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FCGR2A promoter sequence
   Search Chromatin IP Primers for FCGR2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

FCGR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR2A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161475:  view genomic region     (about GC identifiers)

Start:
161,475,205 bp from pter      End:
161,493,803 bp from pter
Size:
18,599 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318 (See protein sequence)
Recommended Name: Low affinity immunoglobulin gamma Fc region receptor II-a precursor  
Size: 317 amino acids; 35001 Da
Subunit: Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR.
Interacts with HCK
Sequence caution: Sequence=AAA35932.1; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for FCGR2A:
1FCG (3D)        1H9V (3D)        3D5O (3D)        3RY4 (3D)        3RY5 (3D)        3RY6 (3D)    
Secondary accessions: Q8WUN1 Q8WW64
Alternative splicing: 2 isoforms:  P12318-1   P12318-2   

Explore the universe of human proteins at neXtProt for FCGR2A: NX_P12318

Explore proteomics data for FCGR2A at MOPED

Post-translational modifications: 

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK1
  • Glycosylation2 at Asn97, Asn178
  • Modification sites at PhosphoSitePlus

  • See FCGR2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129691.1  NP_067674.2  

    ENSEMBL proteins: 
     ENSP00000356949   ENSP00000271450   ENSP00000441156   ENSP00000440148   ENSP00000476495  
     ENSP00000476411  
    Reactome Protein details: P12318

    FCGR2A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCGR2A (Fc gamma RIIA/CD32a)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FCGR2A
    OriGene Protein Over-expression Lysate for FCGR2A
    OriGene MassSpec for FCGR2A
    OriGene Custom Protein Services for FCGR2A
    GenScript Custom Purified and Recombinant Proteins Services for FCGR2A
    Novus Biologicals FCGR2A Proteins
    Novus Biologicals FCGR2A Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for FCGR2A
    ProSpec Recombinant Protein for FCGR2A
    Browse Proteins at Cloud-Clone Corp.

    FCGR2A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FCGR2A (Fc gamma RII/CD32, Fc gamma RIIA/CD32a)
    OriGene Antibodies for FCGR2A
    OriGene Custom Antibody Services for FCGR2A
    Novus Biologicals FCGR2A Antibodies
    Abcam antibodies for FCGR2A (P31995, P31994, P12318)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for FCGR2A
    LSBio Antibodies in human, mouse, rat for FCGR2A

    FCGR2A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FCGR2A
    R&D Systems Proteome Profiler Antibody Arrays for FCGR2A (Fc gamma RIIA/CD32a)
    GenScript Custom Assay Services for FCGR2A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P12318

    ProtoNet protein and cluster: P12318

    UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    FCGR2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCG2A_HUMAN, P12318
    Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates
    cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens

         Genatlas biochemistry entry for FCGR2A:
    immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019864IgG binding IEA--
         
    FCGR2A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FCGR2A:
     Decreased influenza A virus in  Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fcgr3):
     hematopoietic system  immune system  mortality/aging  skeleton 

    FCGR2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FCGR2A: Fcgr3tm1Ttk Fcgr3tm1Sjv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCGR2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCGR2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCGR2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCGR2A

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FCGR2A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FCGR2A:
    hsa-miR-3691-5p
    SwitchGear 3'UTR luciferase reporter plasmidFCGR2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FCGR2A
    Predesigned siRNA for gene silencing in human, mouse, rat FCGR2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCGR2A

    Clone
    Products:
         
    OriGene clones in human, mouse for FCGR2A (see all 13)
    OriGene ORF clones in mouse, rat for FCGR2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FCGR2A (NM_021642)
    Sino Biological Human cDNA Clone for FCGR2A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCGR2A
    Browse ESI BIO Cell Lines and PureStem Progenitors for FCGR2A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FCG2A_HUMAN, P12318: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    FCGR2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FCGR2A About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    2Creation of C4 and C2 activators
    FCGR activation0.54
    Role of phospholipids in phagocytosis0.53
    3GPCR Pathway
    NFAT in Immune Response0.58
    4Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    5Fc-GammaR Pathway
    Fc-GammaR Pathway0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FCGR2A
        Fc-GammaR Pathway
    Phospholipase-C Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages
    NFAT in Immune Response
    Phagocytosis of Microbes

    2 BioSystems Pathways for FCGR2A
        Spinal Cord Injury
    Signaling events mediated by PTP1B


    3 Reactome Pathways for FCGR2A
        Regulation of actin dynamics for phagocytic cup formation
    FCGR activation
    Role of phospholipids in phagocytosis


    Selected Kegg Pathways  (Kegg details for FCGR2A) (see all 7):
        Phagosome
    Osteoclast differentiation
    Fc gamma R-mediated phagocytosis
    Leishmaniasis
    Staphylococcus aureus infection


    FCGR2A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FCGR2A: 
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FCGR2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FCGR2A (P123182, 3 ENSP000002714504) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434052, 3, ENSP000003648984MINT-8026703 MINT-8028878 I2D: score=5 STRING: ENSP00000364898
    PIK3R1P279863, ENSP000002743354I2D: score=4 STRING: ENSP00000274335
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    HCKP086313, ENSP000003650124I2D: score=2 STRING: ENSP00000365012
    LGALS3P179313, ENSP000002543014I2D: score=2 STRING: ENSP00000254301
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    FCGR2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGR2A (FCG2A)

    Selected DrugBank Compounds for FCGR2A (see all 19)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CetuximabAnti EGFR (see all 2)205923-56-4target--17139284 17704420 17016423
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    TrastuzumabAnti HER2 (see all 2)180288-69-1target--17704420 17016423 17139284
    Abciximab7E3 (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    DaclizumabAnti-IL-2 (see all 3)152923-56-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for FCGR2A gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    r 131 83 6 15004265 (4), 19026120 (1)
    piceatannol 62.5 1 11344169 (1)
    dihydrotachysterol 59.6 1 1532752 (1)
    tyrosine 52.7 121 11141335 (4), 15130090 (4), 7521687 (4), 16169188 (3) (see all 43)
    histidine 48.7 23 8772237 (2), 10675363 (1), 18165525 (1), 8555090 (1) (see all 15)
    arginine 34.9 33 8772237 (3), 10675363 (1), 18165525 (1), 19232413 (1) (see all 15)
    phenylalanine 33.5 4 11719384 (1), 9382867 (1), 10449433 (1), 12508114 (1)
    wortmannin 28.7 1 12407113 (1)
    rituximab 28.2 8 17324336 (3), 17650444 (1), 14563637 (1), 17594928 (1) (see all 5)
    inositol 26.1 4 9525908 (1), 12773515 (1), 12832410 (1), 11741917 (1)



    FCGR2A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FCGR2A gene (2 alternative transcripts): 
    NM_001136219.1  NM_021642.3  

    Unigene Cluster for FCGR2A:

    Fc fragment of IgG, low affinity IIa, receptor (CD32)
    Hs.352642  [show with all ESTs]
    Unigene Representative Sequence: NM_001136219
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367972 ENST00000271450(uc001gan.3 uc001gam.3 uc021pcz.1 uc021pda.1)
    ENST00000467654 ENST00000473080 ENST00000536731 ENST00000483665 ENST00000497474
    ENST00000482233 ENST00000467525 ENST00000471026 ENST00000461298 ENST00000459885
    ENST00000486608 ENST00000491841
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FCGR2A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FCGR2A:
    hsa-miR-3691-5p
    SwitchGear 3'UTR luciferase reporter plasmidFCGR2A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FCGR2A
    Predesigned siRNA for gene silencing in human, mouse, rat FCGR2A
    Clone
    Products:
         
    OriGene clones in human, mouse for FCGR2A (see all 13)
    OriGene ORF clones in mouse, rat for FCGR2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FCGR2A (NM_021642)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FCGR2A
    OriGene qSTAR qPCR primer pairs in human, mouse for FCGR2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCGR2A
      QuantiTect SYBR Green Assays in human, mouse, rat FCGR2A
      QuantiFast Probe-based Assays in human, mouse, rat FCGR2A

    Additional mRNA sequence: 

    AK225438.1 AK225601.1 AK226059.1 AK298657.1 AK298734.1 AK315225.1 BC019931.1 BC020823.1 
    J03619.1 M28697.1 M31932.1 X62572.1 Y00644.1 

    20 DOTS entries:

    DT.92449395  DT.97844847  DT.87077467  DT.121462482  DT.92449402  DT.95156082  DT.121462532  DT.121462586 
    DT.92449404  DT.92449423  DT.95360629  DT.100057430  DT.100774280  DT.121462502  DT.121462581  DT.121462594 
    DT.85104268  DT.87018412  DT.91650634  DT.91958909 

    Selected AceView cDNA sequences (see all 509):

    CR617159 AU098758 N26395 BQ004838 AB050934 BX335112 NM_021642 NM_001002275 
    BX378680 BM978253 U87565 CR610288 BQ023141 X62572 CR623806 R34695 
    AW117387 CD368312 AA370839 AW452813 CA428150 AL540745 CR590610 CR608780 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FCGR2A expression in normal human tissues (normalized intensities)      FCGR2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGTCTATA
    FCGR2A Expression
    About this image


    FCGR2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Lung (Respiratory System)
    FCGR2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGR2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352642

    UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318
    Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets

        Pathway & Disease-focused RT2 Profiler PCR Array including FCGR2A: 
              Antifungal Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FCGR2A
    OriGene qSTAR qPCR primer pairs in human, mouse for FCGR2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCGR2A
    QuantiTect SYBR Green Assays in human, mouse, rat FCGR2A
    QuantiFast Probe-based Assays in human, mouse, rat FCGR2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCGR2A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgr31 , 5 Fc receptor, IgG, low affinity III1, 5 72.3(n)1
    60.09(a)1
      1 (78.80 cM)5
    141311  NM_010188.51  NP_034318.21 
     1710511745 


    ENSEMBL Gene Tree for FCGR2A (if available)
    TreeFam Gene Tree for FCGR2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FCGR2A gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  
    FCRL42  FCGR1A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    11 SIMAP similar genes for FCGR2A using alignment to 5 protein entries:     FCG2A_HUMAN (see all proteins):
    FCGR2B    FCGR2C    Fc-gamma receptor IIIB    FCGR3B    FCGR3A    FCGR1A
    FCGR1B    FCGR1C    FCRLB    FCER1A    FCRL3

    FCGR2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FCGR2A
    PGOHUM00000258580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FCGR2A (see all 537)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18012741,2,,4
    C,F,O,A,Hother1168030392(-) CCAAAC/TGGGAG 4 H R mis1 ese344Minor allele frequency- N:0.00MN EA NA NS WA CSA EU 9851
    rs354069971,2
    C--132803094(+) AATAC-/TTTTTT 2 -- int10--------
    rs715814121,2
    C--132803107(+) TTTTGT/-GCCAG 2 -- int11Minor allele frequency- -:0.50NA 2
    rs576972821,2
    C--132804157(+) TTTTT-/T/TT/ 
    TTT
    /TTTT
    AACCA
    2 -- int12NA 4
    rs109188871,2
    C,A,H--132807049(+) CCCTCG/AATTTG 2 -- int11Minor allele frequency- A:0.00NA 4
    rs109188881,2
    C,F,A--132807087(+) GGGGTG/AGAGTG 2 -- int12Minor allele frequency- A:0.50NA 4
    rs716390701,2
    C,F--132807155(+) GGGGGC/TTAGGG 2 -- int12Minor allele frequency- T:0.50NA 4
    rs18134941,2
    C,A,H--132807372(-) TTACAC/TACTCC 2 -- int10--------
    rs9864251,2
    C,A,H--132807402(-) AAGTTA/GCCTGG 2 -- int10--------
    rs745998421,2
    C--132807402(+) CCAGGC/TAACTT 2 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for FCGR2A (161475205 - 161493803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCGR2A (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv74e199CNV Deletion23128226
    esv2718873CNV Deletion23290073
    dgv22n16CNV Deletion17901297
    nsv820341CNV Duplication20802225
    esv997087CNV Loss20482838
    nsv3243CNV Loss18451855
    nsv428257CNV Loss18775914
    nsv8502CNV Loss18304495
    dgv17n21CNV Loss19592680
    nsv519779CNV Loss19592680

    Human Gene Mutation Database (HGMD): FCGR2A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCGR2A
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGR2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 146790   
    OMIM disorders: 611162  219700  
    Selected diseases for FCGR2A (see all 111):    About MalaCards
    lupus nephritis    malaria, severe    asymptomatic dengue    pseudomonas aeruginosa chronic infection by, in cystic fibrosis
    cd3zeta deficiency    heparin-induced thrombocytopenia    cryptococcosis    adult-onset still's disease
    infective endocarditis    aggressive periodontitis    nephritis    rheumatic fever
    microscopic polyangiitis    endocarditis    rheumatic disease    brucellosis
    poliomyelitis    myasthenia gravis    bacterial meningitis    malaria

    4 diseases from the University of Copenhagen DISEASES database for FCGR2A:
    Systemic lupus erythematosus     Thrombocytopenia     Nephritis     Periodontitis

    FCGR2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for FCGR2A gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 63.1 21 11561111 (2), 12215902 (2), 10413210 (1), 12215903 (1) (see all 18)
    nephritis 59.5 8 15004265 (4), 11263776 (1), 11480843 (1)
    lupus nephritis 56.7 10 15004265 (3), 11237133 (2), 8636449 (2), 11229467 (1) (see all 6)
    autoimmune diseases 51.2 8 16200626 (2), 16221721 (1), 10882671 (1), 19030019 (1) (see all 7)
    thrombocytopenia 46.4 18 10201963 (3), 11480843 (2), 11434690 (1), 11588041 (1) (see all 13)
    rheumatoid arthritis 39.4 10 16221721 (1), 19030019 (1), 16084773 (1), 12734884 (1) (see all 8)
    meningococcal diseases 34.7 5 7930726 (1), 11812402 (1), 9798027 (1), 15243816 (1)
    purpura thrombocytopenic 33.8 3 18485087 (1)
    malaria falciparum 30.5 5 19284648 (2), 18194515 (1), 17587350 (1)
    autoimmunity 28.2 3 16200626 (2), 10675363 (1)

    Genetic Association Database (GAD): FCGR2A
    Human Genome Epidemiology (HuGE) Navigator: FCGR2A (228 documents)

    Export disorders for FCGR2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FCGR2A gene, integrated from 10 sources (see all 608):
    (articles sorted by number of sources associating them with FCGR2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PubMed id 17324336)1, 4, 7, 9 Hatjiharissi E....Treon S.P. (amp 2007)
    2. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. (PubMed id 17704420)1, 4, 7 Zhang W....Lenz H.J. (J. Clin. Oncol. 2007)
    3. FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia. (PubMed id 15217834)1, 4, 7 Lin T.S....Byrd J.C. (Blood 2005)
    4. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PubMed id 15457442)1, 4, 7 Criswell L.A....Bridges S.L. (Arthritis Rheum. 2004)
    5. Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG. (PubMed id 10397151)1, 2, 9 Powell M.S.... Hogarth P.M. (Immunol. Lett. 1999)
    6. FcgammaRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients. (PubMed id 11480843)1, 4, 9 Yun H.R....Kim S.Y. (Lupus 2001)
    7. The FcgammaRIIa polymorphism in children with atopic diseases. (PubMed id 14976391)1, 4, 9 Pawlik A....GawroA8ska-Szklarz B. (Int. Arch. Allergy Immunol. 2004)
    8. FcgammaRIIa polymorphism in Japanese patients with systemic lupus erythematosus. (PubMed id 11237133)1, 4, 9 Sato H....Dohi K. (Lupus 2001)
    9. Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study. (PubMed id 15583733)1, 4, 9 van der Meer I.M....de Maat M.P. (Thromb. Haemost. 2004)
    10. Platelet FcgammaRIIA His131Arg polymorphism and platelet function: antibodies to platelet-bound fibrinogen induce platelet activation. (PubMed id 12871511)1, 4, 9 Chen J....Bray P.F. (J. Thromb. Haemost. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2212 HGNC: 3616 AceView: HSPA6andFCGR2A Ensembl:ENSG00000143226 euGenes: HUgn2212
    ECgene: FCGR2A Kegg: 2212 H-InvDB: FCGR2A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FCGR2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCGR2A gene:
    Search GeneIP for patents involving FCGR2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for FCGR2A (Fc gamma RII/CD32)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FCGR2A (Fc gamma RIIA/CD32a)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for FCGR2A (Fc gamma RIIA/CD32a)  
     OriGene Antibodies for FCGR2A   OriGene RNAi products in human, mouse, rat for FCGR2A  
     OriGene qPCR primer pairs and template standards for FCGR2A   OriGene Protein Over-expression Lysate for FCGR2A  
     OriGene MassSpec something-or-other for FCGR2A   OriGene clones in human, mouse for FCGR2A  
     OriGene qSTAR qPCR primer pairs in human, mouse for FCGR2A   OriGene Purified Protein for FCGR2A  
     OriGene ORF clones in mouse, rat for FCGR2A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCGR2A   OriGene Custom Protein Services for FCGR2A  

     
     
     Block miRNA regulation of human, mouse, rat FCGR2A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FCGR2A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR2A Predesigned siRNA for gene silencing in human, mouse, rat FCGR2A
     QuantiFast Probe-based Assays in human, mouse, rat FCGR2A QuantiTect SYBR Green Assays in human, mouse, rat FCGR2A
     PCR Arrays including human, mouse, rat FCGR2A Search Chromatin IP Primers for FCGR2A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCGR2A  GeneGlobe Interaction Network for FCGR2A
     Regulatory tfbs in FCGR2A promoter
     GenScript Custom Purified and Recombinant Proteins Services for FCGR2A GenScript cDNA clones with any tag delivered in your preferred vector for FCGR2A
     GenScript Custom Assay Services for FCGR2A GenScript Custom overexpressing Cell Line Services for FCGR2A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FCGR2A (FCG2A)
     Browse Sino Biological Proteins
     Cell Lysates for FCGR2A
     cDNA Clones for FCGR2A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FCGR2A antibodies
     FCGR2A proteins
     FCGR2A lysates
     Antibodies for FCGR2A
     See all of Abcam's Antibodies, Kits and Proteins for FCGR2A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FCGR2A
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FCGR2A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR2A
     SwitchGear 3'UTR luciferase reporter plasmids for FCGR2A
     SwitchGear Promoter luciferase reporter plasmids for FCGR2A
     ThermoFisher Antibodies for FCGR2A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR2A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCGR2A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCGR2A
     LSBio Antibodies in human, mouse, rat for FCGR2A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FCGR2A gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4