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Aliases for FCGR2A Gene

Aliases for FCGR2A Gene

  • Fc Fragment Of IgG Receptor IIa 2 3 5
  • Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32) 2 3
  • Immunoglobulin G Fc Receptor II 2 3
  • IgG Fc Receptor II-A 3 4
  • Fc-Gamma-RIIa 3 4
  • FcRII-A 3 4
  • FCGR2A1 3 4
  • CDw32 3 4
  • IGFR2 3 4
  • FCG2 3 4
  • CD32 3 4
  • Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32) 2
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A 3
  • Fc Gamma Receptor IIa 2
  • Fc-Gamma RII-A 4
  • CD32 Antigen 4
  • CD32A 3
  • FCGR2 3
  • FcGR 3

External Ids for FCGR2A Gene

Previous HGNC Symbols for FCGR2A Gene

  • FCG2
  • FCGR2A1
  • FCGR2

Previous GeneCards Identifiers for FCGR2A Gene

  • GC01P159191
  • GC01P157207
  • GC01P158252
  • GC01P158744
  • GC01P158743
  • GC01P158288
  • GC01P159741
  • GC01P161475
  • GC01P132800

Summaries for FCGR2A Gene

Entrez Gene Summary for FCGR2A Gene

  • This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

CIViC summary for FCGR2A Gene

GeneCards Summary for FCGR2A Gene

FCGR2A (Fc Fragment Of IgG Receptor IIa) is a Protein Coding gene. Diseases associated with FCGR2A include Cystic Fibrosis and Systemic Lupus Erythematosus. Among its related pathways are Toxoplasmosis and Phospholipase-C Pathway. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCGR2C.

UniProtKB/Swiss-Prot for FCGR2A Gene

  • Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Gene Wiki entry for FCGR2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2A Gene

Genomics for FCGR2A Gene

Regulatory Elements for FCGR2A Gene

Enhancers for FCGR2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161066 1.7 FANTOM5 ENCODE dbSUPER 38.6 -436.8 -436801 5.1 HDGF PKNOX1 AGO1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 FCGR2A TSTD1 ARHGAP30 F11R DUSP12 DEDD NECTIN4 ENSG00000232879 KLHDC9 USF1
GH01G161011 1.9 FANTOM5 ENCODE dbSUPER 19.2 -488.2 -488202 11.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TSTD1 ARHGAP30 KLHDC9 FCGR2A USF1 RPSAP18 DEDD LOC105371471 NECTIN4 F11R
GH01G161528 2 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +25.7 25745 4.7 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF143 ZNF207 FOS FCGR2C FCGR2A DUSP12 FCRLA ATF6 FCGR2B HSPA6 FCGR3B RPS23P10 ARHGAP30
GH01G161738 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +234.7 234727 3.5 HDGF ATF1 PKNOX1 CREB3L1 ARNT YBX1 ZNF2 YY1 TCF12 ZNF143 FCRLA FCGR2A DUSP12 ATF6 HSPA6 FCGR3A RN7SL466P
GH01G161736 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 +231.2 231173 0.9 ATF1 ARNT GATA2 CBX5 FOS JUNB ZNF592 MEF2D SMARCA4 PBX2 FCRLB FCRLA FCGR2A FCGR2B DUSP12 ATF6 HSPA6 RN7SL466P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCGR2A on UCSC Golden Path with GeneCards custom track

Genomic Location for FCGR2A Gene

Chromosome:
1
Start:
161,505,415 bp from pter
End:
161,524,048 bp from pter
Size:
18,634 bases
Orientation:
Plus strand

Genomic View for FCGR2A Gene

Genes around FCGR2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR2A Gene

Proteins for FCGR2A Gene

  • Protein details for FCGR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12318-FCG2A_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-a
    Protein Accession:
    P12318
    Secondary Accessions:
    • Q8WUN1
    • Q8WW64

    Protein attributes for FCGR2A Gene

    Size:
    317 amino acids
    Molecular mass:
    35001 Da
    Quaternary structure:
    • Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.
    SequenceCaution:
    • Sequence=AAA35932.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2A Gene

    Alternative splice isoforms for FCGR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2A Gene

Post-translational modifications for FCGR2A Gene

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
  • Glycosylation at isoforms=297 and Asn178
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FCGR2A (Fc gamma RIIA/CD32a)
  • R&D Systems Antibodies for FCGR2A (Fc gamma RII/CD32)
  • Cloud-Clone Corp. Antibodies for FCGR2A

Protein Products

Assay Products

  • Cloud-Clone Corp Assay Kits for FCGR2A

No data available for DME Specific Peptides for FCGR2A Gene

Domains & Families for FCGR2A Gene

Protein Domains for FCGR2A Gene

Suggested Antigen Peptide Sequences for FCGR2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCGR2A: view

No data available for UniProtKB/Swiss-Prot for FCGR2A Gene

Function for FCGR2A Gene

Molecular function for FCGR2A Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage
UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Gene Ontology (GO) - Molecular Function for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2A: view
genes like me logo Genes that share phenotypes with FCGR2A: view

Animal Models for FCGR2A Gene

MGI Knock Outs for FCGR2A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for FCGR2A (Fc gamma RIIA/CD32a)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGR2A Gene

Localization for FCGR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGR2A gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 2
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCGR2A: view

Pathways & Interactions for FCGR2A Gene

genes like me logo Genes that share pathways with FCGR2A: view

Gene Ontology (GO) - Biological Process for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with FCGR2A: view

No data available for SIGNOR curated interactions for FCGR2A Gene

Drugs & Compounds for FCGR2A Gene

(54) Drugs for FCGR2A Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma Target 494
Etanercept Approved, Investigational Pharma Target 403
Trastuzumab Approved, Investigational Pharma Target HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 784
rituximab Approved Pharma Target Therapeutic Antibodies 1692
Abciximab Approved Pharma Target 65

(13) Additional Compounds for FCGR2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGR2A: view

Transcripts for FCGR2A Gene

Unigene Clusters for FCGR2A Gene

Fc fragment of IgG, low affinity IIa, receptor (CD32):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for FCGR2A (Fc gamma RIIA/CD32a)

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2A Gene

No ASD Table

Relevant External Links for FCGR2A Gene

GeneLoc Exon Structure for
FCGR2A
ECgene alternative splicing isoforms for
FCGR2A

Expression for FCGR2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCGR2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR2A Gene

This gene is overexpressed in Whole Blood (x36.4).

Protein differential expression in normal tissues from HIPED for FCGR2A Gene

This gene is overexpressed in Serum (22.9), Peripheral blood mononuclear cells (19.4), and Plasma (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR2A Gene



NURSA nuclear receptor signaling pathways regulating expression of FCGR2A Gene:

FCGR2A

SOURCE GeneReport for Unigene cluster for FCGR2A Gene:

Hs.352642

mRNA Expression by UniProt/SwissProt for FCGR2A Gene:

P12318-FCG2A_HUMAN
Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets.

Evidence on tissue expression from TISSUES for FCGR2A Gene

  • Blood(4.5)
  • Lung(4.5)
  • Spleen(3)
  • Lymph node(2.6)
  • Heart(2.5)
  • Nervous system(2.5)
  • Bone marrow(2.4)
  • Intestine(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FCGR2A: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR2A Gene

Orthologs for FCGR2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGR2A 34 35
  • 98.95 (n)
mouse
(Mus musculus)
Mammalia Fcgr3 34 16 35
  • 72.3 (n)
Fcgr2b 35
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100912061 34
  • 69.6 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 48 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FCGR2C 35
  • 43 (a)
ManyToMany
FCGR2 35
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 25 (a)
OneToMany
Species where no ortholog for FCGR2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR2A Gene

ENSEMBL:
Gene Tree for FCGR2A (if available)
TreeFam:
Gene Tree for FCGR2A (if available)

Paralogs for FCGR2A Gene

Pseudogenes.org Pseudogenes for FCGR2A Gene

genes like me logo Genes that share paralogs with FCGR2A: view

Variants for FCGR2A Gene

Sequence variations from dbSNP and Humsavar for FCGR2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1801274 drug-response 161,509,955(-) CCAAA(C/T)GGGAG nc-transcript-variant, reference, missense
rs1000016627 -- 161,508,554(+) TCCAC(C/T)CCAGC intron-variant
rs1000398158 -- 161,516,398(+) AGGAC(A/G)TAATT intron-variant
rs1000443142 -- 161,504,369(+) TCCAA(A/T)GAATA upstream-variant-2KB
rs1000666994 -- 161,503,751(+) CTCTA(G/T)CTCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FCGR2A Gene

Variant ID Type Subtype PubMed ID
dgv17n21 CNV loss 19592680
dgv22n16 CNV deletion 17901297
dgv447n100 CNV gain 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv74e199 CNV deletion 23128226
dgv8e55 CNV gain 17911159
esv2718873 CNV deletion 23290073
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv33393 CNV gain+loss 17666407
esv3587729 CNV loss 21293372
esv3587730 CNV gain 21293372
esv997087 CNV loss 20482838
nsv1161730 CNV duplication 26073780
nsv3243 CNV deletion 18451855
nsv428257 CNV loss 18775914
nsv464173 CNV gain 19166990
nsv482137 CNV gain 20164927
nsv519779 CNV loss 19592680
nsv820341 CNV duplication 20802225
nsv825176 CNV gain 20364138
nsv8502 CNV loss 18304495
nsv946463 CNV duplication 23825009
nsv946464 CNV duplication 23825009

Variation tolerance for FCGR2A Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGR2A Gene

Human Gene Mutation Database (HGMD)
FCGR2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR2A Gene

Disorders for FCGR2A Gene

MalaCards: The human disease database

(18) MalaCards diseases for FCGR2A Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
systemic lupus erythematosus
  • lupus nephritis
malaria
  • malaria, severe
asymptomatic dengue
infective endocarditis
  • endocarditis, infective
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FCGR2A

Genetic Association Database (GAD)
FCGR2A
Human Genome Epidemiology (HuGE) Navigator
FCGR2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR2A
genes like me logo Genes that share disorders with FCGR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR2A Gene

Publications for FCGR2A Gene

  1. CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study. (PMID: 19055599) Pessi T. … Hurme M. (Int. J. Immunogenet. 2009) 3 22 46 64
  2. FcgammaRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease. (PMID: 19232413) Raaz D. … Garlichs C.D. (Atherosclerosis 2009) 3 22 46 64
  3. FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan. (PMID: 19284648) Nasr A. … Berzins K. (Malar. J. 2009) 3 22 46 64
  4. FcgammaRIIa polymorphism and clinical response to rituximab in non-Hodgkin lymphoma patients. (PMID: 18474295) Paiva M. … Medeiros R. (Cancer Genet. Cytogenet. 2008) 3 22 46 64
  5. FcgammaRIIa, IIIa and IIIb gene polymorphisms in BehAset's disease: do they have any clinical implications? (PMID: 19026120) Aksu K. … Doganavsargil E. (Clin. Exp. Rheumatol. 2008) 3 22 46 64

Products for FCGR2A Gene

Sources for FCGR2A Gene

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