Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FCGR2A Gene

Aliases for FCGR2A Gene

  • Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32) 2 3
  • IGFR2 3 4 6
  • CD32 3 4 6
  • Immunoglobulin G Fc Receptor II 2 3
  • IgG Fc Receptor II-A 3 4
  • Fc-Gamma RII-A 3 4
  • Fc-Gamma-RIIa 3 4
  • FcRII-A 3 4
  • FCGR2A1 3 4
  • CDW32 3 4
  • FCG2 3 4
  • Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32) 2
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A 3
  • CD32 Antigen 4
  • FCGR2 3
  • CD32A 3
  • FcGR 3

External Ids for FCGR2A Gene

Previous HGNC Symbols for FCGR2A Gene

  • FCG2
  • FCGR2A1
  • FCGR2

Previous GeneCards Identifiers for FCGR2A Gene

  • GC01P159191
  • GC01P157207
  • GC01P158252
  • GC01P158744
  • GC01P158743
  • GC01P158288
  • GC01P159741
  • GC01P161475
  • GC01P132800

Summaries for FCGR2A Gene

Entrez Gene Summary for FCGR2A Gene

  • This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

GeneCards Summary for FCGR2A Gene

FCGR2A (Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32)) is a Protein Coding gene. Diseases associated with FCGR2A include cystic fibrosis and asymptomatic dengue. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR2A Gene

  • Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Gene Wiki entry for FCGR2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2A Gene

Genomics for FCGR2A Gene

Regulatory Elements for FCGR2A Gene

Genomic Location for FCGR2A Gene

Start:
161,505,415 bp from pter
End:
161,524,013 bp from pter
Size:
18,599 bases
Orientation:
Plus strand

Genomic View for FCGR2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR2A Gene

Proteins for FCGR2A Gene

  • Protein details for FCGR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12318-FCG2A_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-a
    Protein Accession:
    P12318
    Secondary Accessions:
    • Q8WUN1
    • Q8WW64

    Protein attributes for FCGR2A Gene

    Size:
    317 amino acids
    Molecular mass:
    35001 Da
    Quaternary structure:
    • Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.
    SequenceCaution:
    • Sequence=AAA35932.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2A Gene

    Alternative splice isoforms for FCGR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2A Gene

Proteomics data for FCGR2A Gene at MOPED

Post-translational modifications for FCGR2A Gene

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
  • Glycosylation at Asn97 and Asn178
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGR2A Gene

No data available for DME Specific Peptides for FCGR2A Gene

Domains for FCGR2A Gene

Gene Families for FCGR2A Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCGR2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FCGR2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12318

UniProtKB/Swiss-Prot:

FCG2A_HUMAN :
  • P12318
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCGR2A: view

Function for FCGR2A Gene

Molecular function for FCGR2A Gene

GENATLAS Biochemistry: immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage
UniProtKB/Swiss-Prot Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Gene Ontology (GO) - Molecular Function for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2A: view
genes like me logo Genes that share phenotypes with FCGR2A: view

Animal Models for FCGR2A Gene

MGI Knock Outs for FCGR2A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FCGR2A Gene

Localization for FCGR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR2A Gene COMPARTMENTS Subcellular localization image for FCGR2A gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCGR2A: view

Pathways for FCGR2A Gene

genes like me logo Genes that share pathways with FCGR2A: view

Gene Ontology (GO) - Biological Process for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with FCGR2A: view

Compounds for FCGR2A Gene

(19) Drugbank Compounds for FCGR2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abciximab
  • 7E3
143653-53-6 target
Adalimumab
331731-18-1 target
Alefacept
222535-22-0 target
Alemtuzumab
216503-57-0 target
Basiliximab
  • chimeric mouse-human antiCD25
152923-56-3 target

(39) Novoseek inferred chemical compound relationships for FCGR2A Gene

Compound -log(P) Hits PubMed IDs
r 131 83 5
piceatannol 62.5 1
dihydrotachysterol 59.6 1
tyrosine 52.7 84
histidine 48.7 16

(1) PharmGKB related drug/compound annotations for FCGR2A Gene

Drug/compound Annotation
infliximab CA
genes like me logo Genes that share compounds with FCGR2A: view

Transcripts for FCGR2A Gene

Unigene Clusters for FCGR2A Gene

Fc fragment of IgG, low affinity IIa, receptor (CD32):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2A Gene

No ASD Table

Relevant External Links for FCGR2A Gene

GeneLoc Exon Structure for
FCGR2A
ECgene alternative splicing isoforms for
FCGR2A

Expression for FCGR2A Gene

mRNA expression in normal human tissues for FCGR2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR2A Gene

This gene is overexpressed in Whole Blood (36.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCGR2A Gene

SOURCE GeneReport for Unigene cluster for FCGR2A Gene Hs.352642

mRNA Expression by UniProt/SwissProt for FCGR2A Gene

P12318-FCG2A_HUMAN
Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets
genes like me logo Genes that share expressions with FCGR2A: view

Orthologs for FCGR2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGR2A 35
  • 98.95 (n)
  • 97.47 (a)
FCGR2A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCGR2 36
  • 41 (a)
ManyToMany
FCGR2C 36
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 48 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fcgr2b 36
  • 43 (a)
ManyToMany
Fcgr3 35
  • 72.3 (n)
  • 60.09 (a)
Fcgr3 16
Fcgr3 36
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100912061 35
  • 69.6 (n)
  • 56.94 (a)
Species with no ortholog for FCGR2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR2A Gene

ENSEMBL:
Gene Tree for FCGR2A (if available)
TreeFam:
Gene Tree for FCGR2A (if available)

Paralogs for FCGR2A Gene

Selected SIMAP similar genes for FCGR2A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FCGR2A Gene

genes like me logo Genes that share paralogs with FCGR2A: view

Variants for FCGR2A Gene

Sequence variations from dbSNP and Humsavar for FCGR2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12721 -- 161,519,263(+) CAAAT(A/G)ACTGA utr-variant-3-prime
rs13878 -- 161,518,174(+) GGTCA(C/T)ACTCT utr-variant-3-prime
rs368433 -- 161,514,420(-) tttga(A/G)taaga intron-variant
rs368660 -- 161,517,697(-) tcaaa(A/G)tggaa intron-variant
rs368999 -- 161,517,302(-) ttcaa(C/G)cATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGR2A Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
nsv3243 CNV Loss 18451855
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv482137 CNV Gain 20164927
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
dgv17n21 CNV Loss 19592680
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
nsv872494 CNV Gain 21882294
dgv397n71 CNV Gain 21882294
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv22n16 CNV Deletion 17901297
dgv74e199 CNV Deletion 23128226

Relevant External Links for FCGR2A Gene

HapMap Linkage Disequilibrium report
FCGR2A
Human Gene Mutation Database (HGMD)
FCGR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR2A Gene

Disorders for FCGR2A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (11) Diseases for FCGR2A Gene including...

Search for FCGR2A Gene in MalaCards »

(2) OMIM Diseases for FCGR2A Gene (146790)

(4) University of Copenhagen DISEASES for FCGR2A Gene

(41) Novoseek inferred disease relationships for FCGR2A Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 63.1 20
nephritis 59.5 6
lupus nephritis 56.7 10
autoimmune diseases 51.2 8
thrombocytopenia 46.4 16

Relevant External Links for FCGR2A

Genetic Association Database (GAD)
FCGR2A
Human Genome Epidemiology (HuGE) Navigator
FCGR2A
genes like me logo Genes that share disorders with FCGR2A: view

No data available for UniProtKB/Swiss-Prot for FCGR2A Gene

Publications for FCGR2A Gene

  1. Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PMID: 17324336) Hatjiharissi E. … Treon S.P. (Clin Lymphoma Myeloma 2007) 3 23 25 48
  2. In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. (PMID: 8756631) Bewarder N. … Frey J. (Mol. Cell. Biol. 1996) 3 4 23
  3. Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG. (PMID: 10397151) Powell M.S. … Hogarth P.M. (Immunol. Lett. 1999) 3 4 23
  4. Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. (PMID: 8636449) Salmon J.E. … Kimberly R.P. (J. Clin. Invest. 1996) 3 4 23
  5. Allelic polymorphisms of human fcgamma receptor IIa and Fcgamma receptor IIIb among distinct groups in Brazil. (PMID: 11099670) Kuwano S.T. … Kerbauy J. (Transfusion 2000) 3 23 48

Products for FCGR2A Gene

Sources for FCGR2A Gene

Back to Top

Content