Aliases for FCGR2A Gene
Aliases for FCGR2A Gene
External Ids for FCGR2A Gene
- HGNC: 3616
- Entrez Gene: 2212
- Ensembl: ENSG00000143226
- OMIM: 146790
- UniProtKB: P12318
Previous HGNC Symbols for FCGR2A Gene
- FCG2
- FCGR2A1
- FCGR2
Previous GeneCards Identifiers for FCGR2A Gene
- GC01P159191
- GC01P157207
- GC01P158252
- GC01P158744
- GC01P158743
- GC01P158288
- GC01P159741
- GC01P161475
- GC01P132800
Summaries for FCGR2A Gene
-
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
GeneCards Summary for FCGR2A Gene
FCGR2A (Fc Fragment Of IgG Receptor IIa) is a Protein Coding gene. Diseases associated with FCGR2A include Cystic Fibrosis and Systemic Lupus Erythematosus. Among its related pathways are Toxoplasmosis and Phospholipase-C Pathway. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCGR2C.
UniProtKB/Swiss-Prot for FCGR2A Gene
-
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2A Gene
Genomics for FCGR2A Gene
Regulatory Elements for FCGR2A Gene
Regulatory Element Products
Genomic Location for FCGR2A Gene
- Chromosome:
- 1
- Start:
- 161,505,415 bp from pter
- End:
- 161,524,048 bp from pter
- Size:
- 18,634 bases
- Orientation:
- Plus strand
Genomic View for FCGR2A Gene
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCGR2A Gene
Proteins for FCGR2A Gene
-
Protein details for FCGR2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12318-FCG2A_HUMAN
- Recommended name:
- Low affinity immunoglobulin gamma Fc region receptor II-a
- Protein Accession:
- P12318
- Q8WUN1
- Q8WW64
Protein attributes for FCGR2A Gene
- Size:
- 317 amino acids
- Molecular mass:
- 35001 Da
- Quaternary structure:
-
- Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.
- SequenceCaution:
-
- Sequence=AAA35932.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for FCGR2A Gene
Protein Expression for FCGR2A Gene
Post-translational modifications for FCGR2A Gene
- Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
- Glycosylation at isoforms=297 and Asn178
- Modification sites at PhosphoSitePlus
Other Protein References for FCGR2A Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FCGR2A
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Protein Products
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Cloud-Clone Corp. Proteins for FCGR2A
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ProSci Proteins for FCGR2A
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for FCGR2A (Fc gamma RIIA/CD32a)
-
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- antibodies-online Kits for FCGR2A: See all 37
No data available for DME Specific Peptides for FCGR2A Gene
Domains & Families for FCGR2A Gene
Gene Families for FCGR2A Gene
Protein Domains for FCGR2A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCGR2A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCGR2A Gene
Function for FCGR2A Gene
Molecular function for FCGR2A Gene
- GENATLAS Biochemistry:
- immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage
- UniProtKB/Swiss-Prot Function:
- Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0019864 | IgG binding | IEA | -- |
Phenotypes for FCGR2A Gene
- MGI mutant phenotypes for FCGR2A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FCGR2A:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased influenza A virus infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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CRISPR Products
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miRNA for FCGR2A Gene
- miRTarBase miRNAs that target FCGR2A
miRNA Products
- Search ViGene Biosciences for FCGR2A
Inhibitory RNA Products
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Clone Products
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Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGR2A Gene
Localization for FCGR2A Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCGR2A Gene
- Cell membrane; Single-pass type I membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030667 | secretory granule membrane | TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for FCGR2A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | IgA-Producing B Cells in the Intestine | ||
| 3 | Regulation of actin dynamics for phagocytic cup formation | ||
| 4 | Role of phospholipids in phagocytosis |
.39
|
|
| 5 | Fc gamma R-mediated phagocytosis | ||
Pathways by source for FCGR2A Gene
2 BioSystems pathways for FCGR2A Gene
7 Reactome pathways for FCGR2A Gene
8 KEGG pathways for FCGR2A Gene
3 R&D Systems pathways for FCGR2A Gene
5 Qiagen pathways for FCGR2A Gene
Interacting Proteins for FCGR2A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for FCGR2A Gene
Drugs & Compounds for FCGR2A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adalimumab | Approved | Pharma | Target | 494 | ||
| Etanercept | Approved, Investigational | Pharma | Target | 403 | ||
| Trastuzumab | Approved, Investigational | Pharma | Target | HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 784 | |
| rituximab | Approved | Pharma | Target | Therapeutic Antibodies | 1692 | |
| Abciximab | Approved | Pharma | Target | 65 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FCGR2A Gene
mRNA/cDNA for FCGR2A Gene
- (11) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (509) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCGR2A Gene
- Fc fragment of IgG, low affinity IIa, receptor (CD32):
- Representative Sequences:
CRISPR Products
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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Flow Cytometry Products
Expression for FCGR2A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Bone Marrow
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for FCGR2A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR2A Gene
NURSA nuclear receptor signaling pathways regulating expression of FCGR2A Gene:
FCGR2ASOURCE GeneReport for Unigene cluster for FCGR2A Gene:
Hs.352642mRNA Expression by UniProt/SwissProt for FCGR2A Gene:
P12318-FCG2A_HUMANEvidence on tissue expression from TISSUES for FCGR2A Gene
- Blood(4.5)
- Lung(4.5)
- Spleen(3)
- Lymph node(2.6)
- Heart(2.5)
- Nervous system(2.5)
- Bone marrow(2.4)
- Intestine(2.3)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for FCGR2A
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OriGene qPCR primer pairs and template standards for FCGR2A
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR2A Gene
Orthologs for FCGR2A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCGR2A 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcgr3 34 16 35 |
|
||
| Fcgr2b 35 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | LOC100912061 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | FCGR2C 35 |
|
ManyToMany | |
| FCGR2 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany |
- Species where no ortholog for FCGR2A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCGR2A Gene
Paralogs for FCGR2A Gene
(11) SIMAP similar genes for FCGR2A Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for FCGR2A Gene
Variants for FCGR2A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1801274 | drug-response | 161,509,955(-) | CCAAA(C/T)GGGAG | nc-transcript-variant, reference, missense | |
| rs1000016627 | -- | 161,508,554(+) | TCCAC(C/T)CCAGC | intron-variant | |
| rs1000398158 | -- | 161,516,398(+) | AGGAC(A/G)TAATT | intron-variant | |
| rs1000443142 | -- | 161,504,369(+) | TCCAA(A/T)GAATA | upstream-variant-2KB | |
| rs1000666994 | -- | 161,503,751(+) | CTCTA(G/T)CTCTG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv17n21 | CNV | loss | 19592680 |
| dgv22n16 | CNV | deletion | 17901297 |
| dgv447n100 | CNV | gain | 25217958 |
| dgv4n68 | CNV | gain+loss | 17160897 |
| dgv5e203 | CNV | gain+loss | 21179565 |
| dgv74e199 | CNV | deletion | 23128226 |
| dgv8e55 | CNV | gain | 17911159 |
| esv2718873 | CNV | deletion | 23290073 |
| esv2758972 | CNV | gain+loss | 17122850 |
| esv28122 | CNV | gain+loss | 19812545 |
| esv33393 | CNV | gain+loss | 17666407 |
| esv3587729 | CNV | loss | 21293372 |
| esv3587730 | CNV | gain | 21293372 |
| esv997087 | CNV | loss | 20482838 |
| nsv1161730 | CNV | duplication | 26073780 |
| nsv3243 | CNV | deletion | 18451855 |
| nsv428257 | CNV | loss | 18775914 |
| nsv464173 | CNV | gain | 19166990 |
| nsv482137 | CNV | gain | 20164927 |
| nsv519779 | CNV | loss | 19592680 |
| nsv820341 | CNV | duplication | 20802225 |
| nsv825176 | CNV | gain | 20364138 |
| nsv8502 | CNV | loss | 18304495 |
| nsv946463 | CNV | duplication | 23825009 |
| nsv946464 | CNV | duplication | 23825009 |
Relevant External Links for FCGR2A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR2A Gene
Disorders for FCGR2A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cystic fibrosis |
|
|
| systemic lupus erythematosus |
|
|
| malaria |
|
|
| asymptomatic dengue |
|
|
| infective endocarditis |
|
|
Relevant External Links for FCGR2A
No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR2A Gene
Publications for FCGR2A Gene
- CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study. (PMID: 19055599) Pessi T. … Hurme M. (Int. J. Immunogenet. 2009) 3 22 46 64
- FcgammaRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease. (PMID: 19232413) Raaz D. … Garlichs C.D. (Atherosclerosis 2009) 3 22 46 64
- FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan. (PMID: 19284648) Nasr A. … Berzins K. (Malar. J. 2009) 3 22 46 64
- FcgammaRIIa polymorphism and clinical response to rituximab in non-Hodgkin lymphoma patients. (PMID: 18474295) Paiva M. … Medeiros R. (Cancer Genet. Cytogenet. 2008) 3 22 46 64
- FcgammaRIIa, IIIa and IIIb gene polymorphisms in BehAset's disease: do they have any clinical implications? (PMID: 19026120) Aksu K. … Doganavsargil E. (Clin. Exp. Rheumatol. 2008) 3 22 46 64
Products for FCGR2A Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for FCGR2A gene
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCGR2A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




