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Aliases for FCGR2A Gene

Aliases for FCGR2A Gene

  • Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32) 2 3
  • Immunoglobulin G Fc Receptor II 2 3
  • IgG Fc Receptor II-A 3 4
  • Fc-Gamma RII-A 3 4
  • Fc-Gamma-RIIa 3 4
  • FcRII-A 3 4
  • FCGR2A1 3 4
  • CDW32 3 4
  • IGFR2 3 4
  • CD32 3 4
  • FCG2 3 4
  • Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32) 2
  • CD32 Antigen 4
  • FCGR2 3
  • CD32A 3
  • FcGR 3

External Ids for FCGR2A Gene

Previous HGNC Symbols for FCGR2A Gene

  • FCG2
  • FCGR2A1
  • FCGR2

Previous GeneCards Identifiers for FCGR2A Gene

  • GC01P159191
  • GC01P157207
  • GC01P158252
  • GC01P158744
  • GC01P158743
  • GC01P158288
  • GC01P159741
  • GC01P161475
  • GC01P132800

Summaries for FCGR2A Gene

Entrez Gene Summary for FCGR2A Gene

  • This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

GeneCards Summary for FCGR2A Gene

FCGR2A (Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32)) is a Protein Coding gene. Diseases associated with FCGR2A include asymptomatic dengue and cystic fibrosis. Among its related pathways are Immune System and GPCR Pathway. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR2A Gene

  • Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Gene Wiki entry for FCGR2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2A Gene

Genomics for FCGR2A Gene

Regulatory Elements for FCGR2A Gene

Genomic Location for FCGR2A Gene

Chromosome:
1
Start:
161,505,415 bp from pter
End:
161,524,048 bp from pter
Size:
18,634 bases
Orientation:
Plus strand

Genomic View for FCGR2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR2A Gene

Proteins for FCGR2A Gene

  • Protein details for FCGR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12318-FCG2A_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-a
    Protein Accession:
    P12318
    Secondary Accessions:
    • Q8WUN1
    • Q8WW64

    Protein attributes for FCGR2A Gene

    Size:
    317 amino acids
    Molecular mass:
    35001 Da
    Quaternary structure:
    • Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.
    SequenceCaution:
    • Sequence=AAA35932.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2A Gene

    Alternative splice isoforms for FCGR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2A Gene

Proteomics data for FCGR2A Gene at MOPED

Post-translational modifications for FCGR2A Gene

  • Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
  • Glycosylation at Asn 97 and Asn 178
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGR2A Gene

Antibody Products

  • R&D Systems Antibodies for FCGR2A (Fc gamma RIIA/CD32a)
  • R&D Systems Antibodies for FCGR2A (Fc gamma RII/CD32)

No data available for DME Specific Peptides for FCGR2A Gene

Domains & Families for FCGR2A Gene

Gene Families for FCGR2A Gene

Protein Domains for FCGR2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FCGR2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12318

UniProtKB/Swiss-Prot:

FCG2A_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCGR2A: view

Function for FCGR2A Gene

Molecular function for FCGR2A Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage
UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Gene Ontology (GO) - Molecular Function for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2A: view
genes like me logo Genes that share phenotypes with FCGR2A: view

Animal Models for FCGR2A Gene

MGI Knock Outs for FCGR2A:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR2A

Clone Products

  • R&D Systems cDNA Clones for FCGR2A (Fc gamma RIIA/CD32a)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FCGR2A Gene

Localization for FCGR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR2A Gene COMPARTMENTS Subcellular localization image for FCGR2A gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1
cytosol 1
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCGR2A: view

Pathways & Interactions for FCGR2A Gene

genes like me logo Genes that share pathways with FCGR2A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FCGR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with FCGR2A: view

No data available for SIGNOR curated interactions for FCGR2A Gene

Drugs & Compounds for FCGR2A Gene

(49) Drugs for FCGR2A Gene - From: NovoSeek, DrugBank, PharmGKB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma Target 94,126
Adalimumab Approved Pharma Target 411
Etanercept Approved, Investigational Pharma Target 0
Trastuzumab Approved, Investigational Pharma Target HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 688
rituximab Approved Pharma Target Therapeutic Antibodies 1514

(16) Additional Compounds for FCGR2A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Actinomycin D
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Cytochalasin D
FMLP
H2O2
genes like me logo Genes that share compounds with FCGR2A: view

Transcripts for FCGR2A Gene

Unigene Clusters for FCGR2A Gene

Fc fragment of IgG, low affinity IIa, receptor (CD32):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR2A

Clone Products

  • R&D Systems cDNA Clones for FCGR2A (Fc gamma RIIA/CD32a)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2A Gene

No ASD Table

Relevant External Links for FCGR2A Gene

GeneLoc Exon Structure for
FCGR2A
ECgene alternative splicing isoforms for
FCGR2A

Expression for FCGR2A Gene

mRNA expression in normal human tissues for FCGR2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR2A Gene

This gene is overexpressed in Whole Blood (x36.4).

Protein differential expression in normal tissues from HIPED for FCGR2A Gene

This gene is overexpressed in Serum (22.9), Peripheral blood mononuclear cells (19.4), and Plasma (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR2A Gene



SOURCE GeneReport for Unigene cluster for FCGR2A Gene Hs.352642

mRNA Expression by UniProt/SwissProt for FCGR2A Gene

P12318-FCG2A_HUMAN
Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets
genes like me logo Genes that share expression patterns with FCGR2A: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FCGR2A Gene

Orthologs for FCGR2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR2A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Fcgr3 35
  • 72.3 (n)
  • 60.09 (a)
Fcgr3 16
Fcgr2b 36
  • 43 (a)
ManyToMany
Fcgr3 36
  • 51 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia FCGR2A 35
  • 98.95 (n)
  • 97.47 (a)
FCGR2A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912061 35
  • 69.6 (n)
  • 56.94 (a)
cow
(Bos Taurus)
Mammalia FCGR2 36
  • 41 (a)
ManyToMany
FCGR2C 36
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for FCGR2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR2A Gene

ENSEMBL:
Gene Tree for FCGR2A (if available)
TreeFam:
Gene Tree for FCGR2A (if available)

Paralogs for FCGR2A Gene

Pseudogenes.org Pseudogenes for FCGR2A Gene

genes like me logo Genes that share paralogs with FCGR2A: view

Variants for FCGR2A Gene

Sequence variations from dbSNP and Humsavar for FCGR2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13878 -- 161,518,174(+) GGTCA(C/T)ACTCT utr-variant-3-prime, intron-variant
rs368433 -- 161,514,420(-) tttga(A/G)taaga intron-variant
rs368660 -- 161,517,697(-) tcaaa(A/G)tggaa intron-variant
rs368999 -- 161,517,302(-) ttcaa(C/G)cATTT intron-variant
rs372617 -- 161,520,501(+) caaga(C/T)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGR2A Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
nsv3243 CNV Loss 18451855
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv482137 CNV Gain 20164927
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
dgv17n21 CNV Loss 19592680
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
nsv872494 CNV Gain 21882294
dgv397n71 CNV Gain 21882294
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv22n16 CNV Deletion 17901297
dgv74e199 CNV Deletion 23128226

Variation tolerance for FCGR2A Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGR2A Gene

HapMap Linkage Disequilibrium report
FCGR2A
Human Gene Mutation Database (HGMD)
FCGR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR2A Gene

Disorders for FCGR2A Gene

MalaCards: The human disease database

(22) MalaCards diseases for FCGR2A Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
asymptomatic dengue
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
infective endocarditis
  • endocarditis, infective
systemic lupus erythematosus
  • lupus nephritis
dengue hemorrhagic fever
  • dhf
- elite association

Relevant External Links for FCGR2A

Genetic Association Database (GAD)
FCGR2A
Human Genome Epidemiology (HuGE) Navigator
FCGR2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR2A
genes like me logo Genes that share disorders with FCGR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR2A Gene

Publications for FCGR2A Gene

  1. Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. (PMID: 17324336) Hatjiharissi E. … Treon S.P. (Clin Lymphoma Myeloma 2007) 23 25 67
  2. Analysis of FcgammaRIIA cytoplasmic tail requirements in signaling for serotonin secretion: evidence for an ITAM-dependent, PI3K-dependent pathway. (PMID: 20384866) Daniels A.B. … Schreiber A.D. (Scand. J. Immunol. 2010) 23 67
  3. Does activation of the FcgammaRIIa play a role in the pathogenesis of the acute lung injury/acute respiratory distress syndrome? (PMID: 20088831) Fudala R. … Kurdowska A.K. (Clin. Sci. 2010) 23 67
  4. FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan. (PMID: 19284648) Nasr A. … Berzins K. (Malar. J. 2009) 23 67
  5. Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa. (PMID: 19420354) Dai X. … MacAry P.A. (Blood 2009) 23 67

Products for FCGR2A Gene

Sources for FCGR2A Gene

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