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Aliases for FCGR1C Gene

Aliases for FCGR1C Gene

  • Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64), Pseudogene 2 3
  • Fc Fragment Of IgG, High Affinity Ic, Receptor For (CD64) 2 3
  • FCRIC 3 4
  • IGFRC 3 4
  • Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64) 2
  • Immunoglobulin Gamma Fc Receptor 1C 3
  • IgG Fc Receptor IC 4
  • Fc-Gamma RIC 4
  • HFcgammaRIC 4
  • IGFR1 3
  • CD64c 3

External Ids for FCGR1C Gene

Previous GeneCards Identifiers for FCGR1C Gene

  • GC01U990045
  • GC01P147637
  • GC01P149320
  • GC01P149372

Summaries for FCGR1C Gene

Entrez Gene Summary for FCGR1C Gene

  • The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be a pseudogene of Fc-gamma-receptor 1A. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCGR1C Gene

FCGR1C (Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64), Pseudogene) is a Pseudogene. GO annotations related to this gene include IgG binding.

UniProtKB/Swiss-Prot for FCGR1C Gene

  • May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR1C Gene

Genomics for FCGR1C Gene

Regulatory Elements for FCGR1C Gene

Genomic Location for FCGR1C Gene

143,874,743 bp from pter
143,883,733 bp from pter
8,991 bases
Plus strand

Genomic View for FCGR1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR1C Gene

Proteins for FCGR1C Gene

  • Protein details for FCGR1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative high affinity immunoglobulin gamma Fc receptor IC
    Protein Accession:
    Secondary Accessions:

    Protein attributes for FCGR1C Gene

    280 amino acids
    Molecular mass:
    32164 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FCGR1C Gene

Proteomics data for FCGR1C Gene at MOPED

Post-translational modifications for FCGR1C Gene

  • Glycosylation at Asn59, Asn152, and Asn163
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCGR1C Gene

Domains for FCGR1C Gene

Gene Families for FCGR1C Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCGR1C Gene

Suggested Antigen Peptide Sequences for FCGR1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A6NKC4
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
genes like me logo Genes that share domains with FCGR1C: view

Function for FCGR1C Gene

Molecular function for FCGR1C Gene

GENATLAS Biochemistry:
immunoglobulin G,high affinity Fc receptor 1C,complexing with homodimeric gamma subunit,with the immunoreceptor based inhibition motif (ITIM)
UniProtKB/Swiss-Prot Function:
May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By similarity).

Gene Ontology (GO) - Molecular Function for FCGR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR1C: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FCGR1C Gene

Localization for FCGR1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR1C Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FCGR1C Gene COMPARTMENTS Subcellular localization image for FCGR1C gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FCGR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCGR1C: view

Pathways for FCGR1C Gene

SuperPathways for FCGR1C Gene

No Data Available

Interacting Proteins for FCGR1C Gene

Gene Ontology (GO) - Biological Process for FCGR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with FCGR1C: view

No data available for Pathways by source for FCGR1C Gene

Transcripts for FCGR1C Gene

mRNA/cDNA for FCGR1C Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCGR1C Gene

Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR1C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR1C Gene

No ASD Table

Relevant External Links for FCGR1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCGR1C Gene

mRNA expression in normal human tissues for FCGR1C Gene

mRNA differential expression in normal tissues according to GTEx for FCGR1C Gene

This gene is overexpressed in Whole Blood (14.7) and Brain - Spinal cord (cervical c-1) (5.4).

SOURCE GeneReport for Unigene cluster for FCGR1C Gene Hs.635062

genes like me logo Genes that share expressions with FCGR1C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FCGR1C Gene

Orthologs for FCGR1C Gene

Evolution for FCGR1C Gene

Gene Tree for FCGR1C (if available)
Gene Tree for FCGR1C (if available)

No data available for Orthologs for FCGR1C Gene

Paralogs for FCGR1C Gene

Selected SIMAP similar genes for FCGR1C Gene using alignment to 1 proteins: Pseudogenes for FCGR1C Gene

genes like me logo Genes that share paralogs with FCGR1C: view

No data available for Paralogs for FCGR1C Gene

Variants for FCGR1C Gene

Sequence variations from dbSNP and Humsavar for FCGR1C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs643804 -- 143,879,804(+) tttct(G/T)tttgc intron-variant
rs651058 -- 143,882,959(+) AGCTC(C/T)AGAAC intron-variant
rs651537 -- 143,883,059(+) CTAGG(A/G)AGTAA intron-variant
rs676359 -- 143,874,146(+) TATTG(C/T)TATCC upstream-variant-2KB
rs9629005 -- 143,881,047(+) TGGAA(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGR1C Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
dgv7e55 CNV Loss 17911159
esv2750807 CNV Gain 17911159
dgv122e1 CNV Complex 17122850
nsv508604 CNV Loss 20534489
esv33539 CNV Gain+Loss 17666407
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
dgv361n71 CNV Gain 21882294
dgv362n71 CNV Gain 21882294
dgv126e1 CNV Complex 17122850
nsv872306 CNV Gain 21882294
dgv367n71 CNV Loss 21882294
dgv368n71 CNV Gain 21882294
nsv8302 CNV Gain 18304495
esv21838 CNV Gain+Loss 19812545
nsv470736 CNV Gain 18288195
esv2750809 CNV Gain 17911159
dgv374n71 CNV Loss 21882294
dgv375n71 CNV Loss 21882294
nsv872378 CNV Gain 21882294
dgv376n71 CNV Gain 21882294
nsv872384 CNV Gain 21882294
dgv19n16 CNV Insertion 17901297
nsv872386 CNV Loss 21882294
esv2421626 CNV Deletion 20811451
esv2658545 CNV Deletion 23128226
dgv377n71 CNV Loss 21882294
dgv378n71 CNV Gain 21882294
nsv436282 CNV Deletion 17901297
dgv20n16 CNV Deletion 17901297

Relevant External Links for FCGR1C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR1C Gene

Disorders for FCGR1C Gene

No disorders were found for FCGR1C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FCGR1C Gene

Publications for FCGR1C Gene

  1. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco D.L. … Anderson C.L. (Cytogenet. Cell Genet. 1996) 2 3 4
  2. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco D.L. … Theil K.S. (Cytogenet. Cell Genet. 1998) 2 3
  3. Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. (PMID: 9881690) Ernst L.K. … Anderson C.L. (Mol. Immunol. 1998) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PMID: 1379234) Ernst L.K. … Anderson C.L. (J. Biol. Chem. 1992) 3

Products for FCGR1C Gene

Sources for FCGR1C Gene

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