FCGR1C Gene
pseudogene GIFtS: 30
GCID: GC01P149320
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Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene(Previous names: Fc fragment of IgG, high affinity Ic, receptor for (CD64),...)
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Aliases
for FCGR1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64), Pseudogene1 2 | | IGFR12 | | CD64c1 2 | | FcRIC3 | | IGFRC2 3 | | Fc-Gamma RIC3 | | Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64)1 | | HFcgammaRIC1 | | Fc Fragment Of IgG, High Affinity Ic, Receptor For (CD64)1 | | IgG Fc Receptor IC3 | | FCRIC2 | | |
Export aliases for FCGR1C gene to outside databasesPrevious GC identifers: GC01U990045 GC01P147637 |
Summaries
for FCGR1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FCGR1C:
The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This familymember lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be apseudogene of Fc-gamma-receptor 1A. (provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4Function: May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (Bysimilarity)
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Genomic Views
for FCGR1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCGR1C gene promoter:
c-Fos HOXA9 HOXA9B AP-1 NF-E2 p45 HNF-3beta Meis-1b c-Jun NF-E2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCGR1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.1FCGR1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P149320: view genomic region
(about GC identifiers)
Start:
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149,320,441 bp from pter |
End:
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149,378,365 bp from pter |
Size:
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57,925 bases |
Orientation:
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plus strand |
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Proteins
for FCGR1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4 (See
protein sequence)Recommended Name: Putative high affinity immunoglobulin gamma Fc receptor IC precursor Size: 280 amino acids; 32164 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for FCGR1C: NX_A6NKC4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NKC4
FCGR1C Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FCGR1C for ontologies About GeneDecksing
FCGR1C Antibody Products:
Assay Products for FCGR1C: |
Protein
Domains /
Families
for FCGR1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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FCGR1C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NKC4ProtoNet protein and cluster: A6NKC4 UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4Similarity: Belongs to the immunoglobulin superfamily. FCGR1 familySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for FCGR1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4Function: May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (Bysimilarity) Genatlas biochemistry entry for FCGR1C:immunoglobulin G,high affinity Fc receptor 1C,complexing with homodimeric gamma subunit,with the immunoreceptor basedinhibition motif (ITIM)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0019864 | IgG binding |
IEA | -- |
FCGR1C for ontologies About GeneDecksing
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Pathways & Interactions
for FCGR1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCGR1C
|
Drugs & Compounds
for FCGR1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for FCGR1C
Search CenterWatch for drugs/clinical trials and news about FCGR1C 
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Transcripts
for FCGR1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for FCGR1C gene: NM_001128589.1 Unigene Cluster for FCGR1C: Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene Hs.635062 [show with all ESTs]Unigene Representative Sequence: NR_0274844 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431573 ENST00000453173(uc010pbg.1) ENST00000413317 ENST00000440993(uc009wkz.1 uc010pbh.2)
Additional cDNA sequence: NR_027484.1 6 DOTS entries: DT.121372988 DT.114591 DT.121330997 DT.121372818 DT.121372964 DT.121372981
GeneLoc Exon Structure
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Expression
for FCGR1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCGR1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for FCGR1C
SOURCE GeneReport for Unigene cluster: Hs.635062
SABiosciences Custom PCR Arrays for FCGR1C
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCGR1C
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FCGR1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGR1C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1C |
Orthologs
for FCGR1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for FCGR1C (if available)
TreeFam Gene Tree for FCGR1C (if available) |
Paralogs
for FCGR1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for FCGR1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FCGR1C (149320441 - 149378365 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for FCGR1C
14 CNVs: 8924 30433 3313 6785 48120 2326 48130 48129 22942 48128 48127 8331 8329 64896 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for FCGR1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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 FCGR1C for disorders About MalaCards
FCGR1C for disorders About GeneDecksing
OMIM gene information: 601503
OMIM disorders: --
Export disorders for FCGR1C gene to outside databases
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Publications
for FCGR1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for FCGR1C gene integrated from 9 sources:
(articles sorted by number of sources associating them with FCGR1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 2, 3 Maresco D.L.... Anderson C.L. (1996)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the ev olution of human chromosome 1. (PubMed id 9763663)1, 3 Maresco D.L....Theil K.S. (1998)
- Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. (PubMed id 9881690)1, 2 Ernst L.K.... Anderson C.L. (1998)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system. (PubMed id 11708889)1 Cox D. and Greenberg S. (2001)
- Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)
- Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PubMed id 1379234)1 Ernst L.K.... Anderson C.L. (1992)
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External Searches for FCGR1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FCGR1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing FCGR1C gene
(According to HUGE)
About This Section
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Specialized Databases showing FCGR1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for FCGR1C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FCGR1C gene:
Search GeneIP for patents involving FCGR1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCGR1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCGR1C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCGR1C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR1C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCGR1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGR1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR1C |
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| | | | Search Tocris compounds for FCGR1C |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1C |
|  |  |  | | | | Search ThermoFisher Antibodies for FCGR1C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FCGR1C |
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