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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCGR1C Gene

pseudogene   GIFtS: 30
GCID: GC01P149320

Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64), Pseudogene

(Previous names: Fc fragment of IgG, high affinity Ic, receptor for (CD64),...)
  Search for FCGR1C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64), Pseudogene1 2     IGFR12
IGFRC2 3     FcRIC3
Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64)1     Fc-Gamma RIC3
Fc Fragment Of IgG, High Affinity Ic, Receptor For (CD64)1     hFcgammaRIC3
CD64c2     IgG Fc Receptor IC3
FCRIC2     

External Ids:    HGNC: 36151   Entrez Gene: 1001324172   Ensembl: ENSG000002531937   OMIM: 6015035   UniProtKB: A6NKC43   

Export aliases for FCGR1C gene to outside databases

Previous GC identifers: GC01U990045 GC01P147637


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCGR1C Gene:
The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This
family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to
be a pseudogene of Fc-gamma-receptor 1A. (provided by RefSeq, Apr 2009)

GeneCards Summary for FCGR1C Gene: 
FCGR1C (Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene) is a pseudogene. GO annotations related to this gene include IgG binding.

UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4
Function: May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCGR1C gene promoter:
         c-Fos   HOXA9   HOXA9B   AP-1   NF-E2 p45   HNF-3beta   Meis-1b   c-Jun   NF-E2   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.1

FCGR1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR1C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149320:  view genomic region     (about GC identifiers)

Start:
149,320,439 bp from pter      End:
149,378,365 bp from pter
Size:
57,927 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4 (See protein sequence)
Recommended Name: Putative high affinity immunoglobulin gamma Fc receptor IC precursor  
Size: 280 amino acids; 32164 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for FCGR1C: NX_A6NKC4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NKC4

  • FCGR1C Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    FCGR1C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry A6NKC4

    ProtoNet protein and cluster: A6NKC4

    UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4
    Similarity: Belongs to the immunoglobulin superfamily. FCGR1 family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    FCGR1C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGRC_HUMAN, A6NKC4
    Function: May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By
    similarity)

         Genatlas biochemistry entry for FCGR1C:
    immunoglobulin G,high affinity Fc receptor 1C,complexing with homodimeric gamma subunit,with the immunoreceptor
    based inhibition motif (ITIM)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019864IgG binding IEA--
         
    FCGR1C for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCGR1C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FCGR1C (FCGRC)

    Search CenterWatch for drugs/clinical trials and news about FCGR1C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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    About This Section

    REFSEQ mRNAs for FCGR1C gene: 
    NM_001128589.1  

    Unigene Cluster for FCGR1C:

    Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene
    Hs.635062  [show with all ESTs]
    Unigene Representative Sequence: NR_027484
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431573 ENST00000453173(uc010pbg.1) ENST00000413317 ENST00000440993(uc009wkz.1 uc010pbh.2)

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    Additional mRNA sequence: NR_027484.1 

    6 DOTS entries:

    DT.121372988  DT.114591  DT.121330997  DT.121372818  DT.121372964  DT.121372981 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCGR1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FCGR1C Expression
    About this image


    Genevestigator expression for FCGR1C

    SOURCE GeneReport for Unigene cluster: Hs.635062
        SABiosciences Custom PCR Arrays for FCGR1C
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for FCGR1C (if available)
    TreeFam Gene Tree for FCGR1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCGR1C gene
    9 SIMAP similar genes for FCGR1C using alignment to 1 protein entry:     FCGRC_HUMAN:
    FCGR1B    FCER1A    FCGR2B    FCGR3A    FCGR3B    Fc-gamma receptor IIIB
    FCGR2A    FCGR2C    FCGR1A

    FCGR1C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/80 SNPs in FCGR1C are shown (see all 80)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0428824
    ----see VAR_0428822 P L mis40--------
    VAR_0428834
    ----see VAR_0428832 T M mis40--------
    VAR_0428844
    ----see VAR_0428842 K M mis40--------
    VAR_0428854
    ----see VAR_0428852 H R mis40--------
    rs1156539591,2
    C--149367451(+) AAGGCA/TTGGGG 1 -- us2k10--------
    rs1856401861,2
    --149367463(+) GGGCAA/CTGTTA 1 -- us2k10--------
    rs1428618521,2
    C--149367694(+) TGCAGC/TGATGA 1 -- us2k10--------
    rs1402673511,2
    C--149368028(+) CTCTCA/GTCTCT 1 -- us2k10--------
    rs2020838951,2
    C--149368056(+) CTTCCC/TGGCCT 1 -- us2k10--------
    rs712212401,2
    C,F--149368105(-) TTGCTA/GTACAA 1 -- us2k13Minor allele frequency- G:0.38NA 8

    HapMap Linkage Disequilibrium report for FCGR1C (149320439 - 149378365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for FCGR1C (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436282CNV Deletion17901297
    esv2421626CNV Deletion20811451
    esv2658545CNV Deletion23128226
    dgv20n16CNV Deletion17901297
    dgv19n16CNV Insertion17901297
    dgv7e55CNV Loss17911159
    dgv375n71CNV Loss21882294
    dgv367n71CNV Loss21882294
    dgv374n71CNV Loss21882294
    nsv872386CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FCGR1C for disorders           About MalaCards
    OMIM gene information: 601503    OMIM disorders: --


    FCGR1C for disorders           About GeneDecksing


    Export disorders for FCGR1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCGR1C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FCGR1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 2, 3 Maresco D.L.... Anderson C.L. (1996)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the ev olution of human chromosome 1. (PubMed id 9763663)1, 3 Maresco D.L....Theil K.S. (1998)
    4. Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. (PubMed id 9881690)1, 2 Ernst L.K.... Anderson C.L. (1998)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system. (PubMed id 11708889)1 Cox D. and Greenberg S. (2001)
    7. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)
    8. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PubMed id 1379234)1 Ernst L.K.... Anderson C.L. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100132417 HGNC: 3615 Ensembl:ENSG00000253193 euGenes: HUgn100132417 ECgene: FCGR1C
    H-InvDB: FCGR1C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCGR1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCGR1C gene:
    Search GeneIP for patents involving FCGR1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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