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FCGR1C Gene

pseudogene   GIFtS: 31
GCID: GC01P149372

Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64), Pseudogene

(Previous names: Fc fragment of IgG, high affinity Ic, receptor for (CD64),...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64), Pseudogene1 2     IGFR12
IGFRC2 3     FcRIC3
Fc Fragment Of IgG, High Affinity Ic, Receptor (CD64)1     Fc-Gamma RIC3
Fc Fragment Of IgG, High Affinity Ic, Receptor For (CD64)1     hFcgammaRIC3
CD64c2     IgG Fc Receptor IC3
FCRIC2     

External Ids:    HGNC: 36151   Entrez Gene: 1001324172   Ensembl: ENSG000002531937   OMIM: 6015035   UniProtKB: A6NKC43   

Export aliases for FCGR1C gene to outside databases

Previous GC identifers: GC01U990045 GC01P147637 GC01P149320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCGR1C Gene:
The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This
family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to
be a pseudogene of Fc-gamma-receptor 1A. (provided by RefSeq, Apr 2009)

GeneCards Summary for FCGR1C Gene:
FCGR1C (Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene) is a pseudogene. GO annotations related to this gene include IgG binding.

UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4
Function: May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGR1C gene promoter:
         c-Fos   HOXA9   HOXA9B   AP-1   NF-E2 p45   HNF-3beta   Meis-1b   c-Jun   NF-E2   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.1

FCGR1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR1C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149372:  view genomic region     (about GC identifiers)

Start:
149,369,294 bp from pter      End:
149,378,365 bp from pter
Size:
9,072 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4 (See protein sequence)
Recommended Name: Putative high affinity immunoglobulin gamma Fc receptor IC precursor  
Size: 280 amino acids; 32164 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for FCGR1C: NX_A6NKC4

Explore proteomics data for FCGR1C at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn59, Asn152, Asn163
  • Modification sites at PhosphoSitePlus

  • See FCGR1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry A6NKC4

    ProtoNet protein and cluster: A6NKC4

    UniProtKB/Swiss-Prot: FCGRC_HUMAN, A6NKC4
    Similarity: Belongs to the immunoglobulin superfamily. FCGR1 family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCGR1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGRC_HUMAN, A6NKC4
    Function: May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By
    similarity)

         Genatlas biochemistry entry for FCGR1C:
    immunoglobulin G,high affinity Fc receptor 1C,complexing with homodimeric gamma subunit,with the immunoreceptor
    based inhibition motif (ITIM)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019864IgG binding IEA--
         
    Find genes that share ontologies with FCGR1C           About GenesLikeMe


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       genOway: Develop your customized and physiologically relevant rodent model for FCGR1C

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCGRC_HUMAN, A6NKC4: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FCGR1C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--

    Find genes that share ontologies with FCGR1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FCGR1C (FCGRC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCGR1C gene: 
    NM_001128589.1  

    Unigene Cluster for FCGR1C:

    Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene
    Hs.635062  [show with all ESTs]
    Unigene Representative Sequence: NR_027484
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453173(uc010pbg.1) ENST00000413317 ENST00000431573 ENST00000440993(uc009wkz.1 uc010pbh.2)

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    Additional mRNA sequence: NR_027484.1 

    6 DOTS entries:

    DT.121372988  DT.114591  DT.121330997  DT.121372818  DT.121372964  DT.121372981 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCGR1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FCGR1C Expression
    About this image

    FCGR1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGR1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.635062
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for FCGR1C (if available)
    TreeFam Gene Tree for FCGR1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCGR1C gene
    9 SIMAP similar genes for FCGR1C using alignment to 1 protein entry:     FCGRC_HUMAN:
    FCGR1B    FCER1A    FCGR2B    FCGR3A    FCGR3B    Fc-gamma receptor IIIB
    FCGR2A    FCGR2C    FCGR1A

    Find genes that share paralogs with FCGR1C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCGR1C (see all 80)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156539591,2
    C--149367451(+) AAGGCA/TTGGGG 1 -- us2k10--------
    rs1856401861,2
    --149367463(+) GGGCAA/CTGTTA 1 -- us2k10--------
    rs1428618521,2
    C--149367694(+) TGCAGC/TGATGA 1 -- us2k10--------
    rs1402673511,2
    C--149368028(+) CTCTCA/GTCTCT 1 -- us2k10--------
    rs2020838951,2
    C--149368056(+) CTTCCC/TGGCCT 1 -- us2k10--------
    rs712212401,2
    C,F--149368105(-) TTGCTA/GTACAA 1 -- us2k13Minor allele frequency- G:0.38NA 8
    rs286447851,2
    C,F--149368184(+) GGCAGC/GTCTGC 1 -- us2k12Minor allele frequency- G:0.50NA 8
    rs286235381,2
    C--149368223(+) GTTTCA/GCACGG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs2003992551,2
    C--149368335(+) CACCAA/TGTCAT 1 -- us2k10--------
    rs286898941,2
    C,F--149368403(+) AGAGAT/CGTACC 1 -- us2k14Minor allele frequency- C:0.38WA NA 8

    HapMap Linkage Disequilibrium report for FCGR1C (149369294 - 149378365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCGR1C (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436282CNV Deletion17901297
    esv2421626CNV Deletion20811451
    esv2658545CNV Deletion23128226
    dgv20n16CNV Deletion17901297
    dgv19n16CNV Insertion17901297
    dgv7e55CNV Loss17911159
    dgv375n71CNV Loss21882294
    dgv367n71CNV Loss21882294
    dgv374n71CNV Loss21882294
    nsv872386CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601503    OMIM disorders: --


    Find genes that share disorders with FCGR1C           About GenesLikeMe


    Export disorders for FCGR1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCGR1C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FCGR1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 2, 3 Maresco D.L.... Anderson C.L. (Cytogenet. Cell Genet. 1996)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PubMed id 9763663)1, 3 Maresco D.L....Theil K.S. (Cytogenet. Cell Genet. 1998)
    4. Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. (PubMed id 9881690)1, 2 Ernst L.K.... Anderson C.L. (Mol. Immunol. 1998)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system. (PubMed id 11708889)1 Cox D. and Greenberg S. (Semin. Immunol. 2001)
    7. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D.... White O. (Nature 1995)
    8. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PubMed id 1379234)1 Ernst L.K.... Anderson C.L. (J. Biol. Chem. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100132417 HGNC: 3615 Ensembl:ENSG00000253193 euGenes: HUgn100132417 ECgene: FCGR1C
    H-InvDB: FCGR1C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCGR1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCGR1C gene:
    Search GeneIP for patents involving FCGR1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat FCGR1C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FCGR1C
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     Custom PCR Arrays for FCGR1C Search Chromatin IP Primers for FCGR1C
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Browse ESI BIO Cell Lines and PureStem Progenitors for FCGR1C
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for FCGR1C
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     Search ThermoFisher Antibodies for FCGR1C
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     Browse compounds at ApexBio
     Search Addgene for plasmids for FCGR1C
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     genOway: Develop your customized and physiologically relevant rodent model for FCGR1C
      Search antibodies-online for antibodies for FCGR1C
     antibodies-online kits for FCGR1C (2 products)
      Search antibodies-online for peptides for FCGR1C
     antibodies-online proteins for FCGR1C
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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