Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FCGR1B Gene

protein-coding   GIFtS: 49
GCID: GC01M120926

Fc Fragment Of IgG, High Affinity Ib, Receptor (CD64)

(Previous names: Fc fragment of IgG, high affinity Ib, receptor for (CD64))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fc Fragment Of IgG, High Affinity Ib, Receptor (CD64)1 2     CD64b2
Fc-Gamma RIB2 3     Fc-Gamma Receptor I B22
IgG Fc Receptor IB2 3     fcRIB2
IGFRB2 3     High Affinity Immunoglobulin Gamma Fc Receptor IB2
hFcgammaRIB2 3     FcRIB3
Fc Fragment Of IgG, High Affinity Ib, Receptor For (CD64)1     

External Ids:    HGNC: 36141   Entrez Gene: 22102   Ensembl: ENSG000001980197   OMIM: 6015025   UniProtKB: Q926373   

Export aliases for FCGR1B gene to outside databases

Previous GC identifers: GC01U990044 GC01M120729 GC01M118453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FCGR1B Gene:
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified
(Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This
gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
(provided by RefSeq, Oct 2011)

GeneCards Summary for FCGR1B Gene:
FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) is a protein-coding gene. GO annotations related to this gene include IgG binding and immunoglobulin receptor activity. An important paralog of this gene is FCGR2B.

UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637
Function: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function
in the humoral immune response




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGR1B gene promoter:
         c-Fos   HOXA9B   HOXA9   STAT1   AP-1   NF-E2 p45   Meis-1b   NF-E2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGR1B promoter sequence
   Search Chromatin IP Primers for FCGR1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p11.2   Ensembl cytogenetic band:  1p11.2   HGNC cytogenetic band: 1p11.2

FCGR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M120926:  view genomic region     (about GC identifiers)

Start:
120,926,908 bp from pter      End:
120,935,944 bp from pter
Size:
9,037 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637 (See protein sequence)
Recommended Name: High affinity immunoglobulin gamma Fc receptor IB precursor  
Size: 280 amino acids; 32232 Da
Secondary accessions: Q7KZ13 Q92638
Alternative splicing: 3 isoforms:  Q92637-1   Q92637-2   Q92637-3   

Explore the universe of human proteins at neXtProt for FCGR1B: NX_Q92637

Explore proteomics data for FCGR1B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn59, Asn78, Asn152, Asn159, Asn163
  • Modification sites at PhosphoSitePlus

  • See FCGR1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001004340.2  NP_001017986.1  NP_001231839.1  

    ENSEMBL proteins: 
     ENSP00000358391   ENSP00000358390  
    Reactome Protein details: Q92637

    FCGR1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FCGR1B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FCGR1B
    GenScript Custom Purified and Recombinant Proteins Services for FCGR1B
    Novus Biologicals FCGR1B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FCGR1B 

     
    antibodies-online proteins for FCGR1B 

     
    antibodies-online peptides for FCGR1B

    FCGR1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FCGR1B
    Abcam antibodies for FCGR1B (A6NKC4, Q92637, P12314)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FCGR1B
    LSBio Antibodies in human, mouse, rat for FCGR1B
    antibodies-online antibodies for FCGR1B (12 products) 

    FCGR1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FCGR1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FCGR1B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FCGR1B 
    antibodies-online kits for FCGR1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q92637

    ProtoNet protein and cluster: Q92637

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637
    Similarity: Belongs to the immunoglobulin superfamily. FCGR1 family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCGR1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGRB_HUMAN, Q92637
    Function: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function
    in the humoral immune response
    Induction: Up-regulated by IFNG/IFN-gamma

         Genatlas biochemistry entry for FCGR1B:
    immunoglobulin G,high affinity Fc receptor 1B,expressed in most cells,complexing with homodimeric gamma
    subunit,with the immunoreceptor based inhibition motif (ITIM)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019763immunoglobulin receptor activity NAS1430234
    GO:0019864IgG binding IEA--
         
    Find genes that share ontologies with FCGR1B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCGR1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCGR1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCGR1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCGR1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target FCGR1B:
    hsa-mir-26b-5p (MIRT029614)

    Block miRNA regulation of human, mouse, rat FCGR1B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FCGR1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FCGR1B
    Predesigned siRNA for gene silencing in human, mouse, rat FCGR1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCGR1B

    Clone
    Products:
         
    OriGene clones in human, mouse for FCGR1B (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FCGR1B (NM_001017986)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR1B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCGR1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for FCGR1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FCGRB_HUMAN, Q92637: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    extracellular2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030669clathrin-coated endocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--

    Find genes that share ontologies with FCGR1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FCGR1B About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    3CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Cross-presentation of soluble exogenous antigens (endosomes)0.80


    Find genes that share SuperPaths with FCGR1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for FCGR1B
        Interferon gamma signaling
    Cross-presentation of soluble exogenous antigens (endosomes)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCGR1B
    Interactions:

        GeneGlobe Interaction Network for FCGR1B

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0006955immune response NAS1430234
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0038093Fc receptor signaling pathway NAS1430234

    Find genes that share ontologies with FCGR1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGR1B (FCGRB)

    1 DrugBank Compound for FCGR1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FCGR1B gene (3 alternative transcripts): 
    NM_001004340.3  NM_001017986.3  NM_001244910.1  

    Unigene Cluster for FCGR1B:

    Fc fragment of IgG, high affinity Ib, receptor (CD64)
    Hs.534956  [show with all ESTs]
    Unigene Representative Sequence: BC032860
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369384(uc010oxl.2 uc001eip.3 uc001eiq.3 uc009whs.2)
    ENST00000369383 ENST00000369178 ENST00000466915 ENST00000472543 ENST00000471609(uc009whr.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FCGR1B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FCGR1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FCGR1B
    Predesigned siRNA for gene silencing in human, mouse, rat FCGR1B
    Clone
    Products:
         
    OriGene clones in human, mouse for FCGR1B (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FCGR1B (NM_001017986)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCGR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR1B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FCGR1B
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FCGR1B
      Search QuantiTect SYBR Green Assays in human, mouse, rat FCGR1B
      QuantiFast Probe-based Assays in human, mouse, rat FCGR1B

    Additional mRNA sequence: 

    AK307244.1 AK308886.1 AK311502.1 BC032860.1 BC110416.1 L03419.1 L03420.1 NR_045213.1 

    10 DOTS entries:

    DT.100754131  DT.99935643  DT.121330997  DT.86850256  DT.40307395  DT.100754134  DT.114591  DT.95196944 
    DT.121372964  DT.121372988 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FCGR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATATAACT
    FCGR1B Expression
    About this image

    FCGR1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGR1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534956
        Custom PCR Arrays for FCGR1B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FCGR1B
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FCGR1B
    Search QuantiTect SYBR Green Assays in human, mouse, rat FCGR1B
    QuantiFast Probe-based Assays in human, mouse, rat FCGR1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
      --

    ENSEMBL Gene Tree for FCGR1B (if available)
    TreeFam Gene Tree for FCGR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FCGR1B gene
    FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  FCRL42  
    FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    10 SIMAP similar genes for FCGR1B using alignment to 1 protein entry:     FCGRB_HUMAN:
    FCGR1C    FCER1A    FCGR3B    FCGR2A    FCGR3A    Fc-gamma receptor IIIB
    FCGR2B    FCGR2C    FCRLB    FCGR1A

    Find genes that share paralogs with FCGR1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FCGR1B (see all 31)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870330511,2
    --121472551(-) CTGGTG/TGGAGT 4 -- ut51 nc-transcript-variant0--------
    rs561581341,2
    C--121472802(+) ACACCG/ACAGTG 4 -- int11Minor allele frequency- A:0.00NA 2
    rs2008396011,2
    F--121472975(-) AGAATA/GAAGAT 4 -- int11Minor allele frequency- G:0.00EU 1153
    rs2019220491,2
    C--121473890(-) GGTTAC/TGGTTT 6 I V mis1 int10--------
    rs2001535811,2
    C--121474014(-) CACCAC/TTGTCA 6 N S mis1 int11Minor allele frequency- T:0.00EU 289
    rs2017805551,2
    C--121474048(-) CTTCGC/TCCTGA 6 G syn1 int11Minor allele frequency- T:0.00EU 817
    rs2009643921,2
    C--121474109(-) TTTCCG/AGCCCT 4 -- int11Minor allele frequency- A:0.00EU 1309
    rs1998538671,2
    C,F--121474110(-) GTTTCC/TGGCCC 4 -- int11Minor allele frequency- T:0.02EU 1301
    rs2019597421,2
    C,F--121474116(-) CTTGTA/GGTTTC 4 -- int11Minor allele frequency- G:0.00EU 1233
    rs5995811,2
    C,A,H--121474217(+) GGTGAA/CACTAA 4 -- int14Minor allele frequency- C:0.00NS EA 360

    HapMap Linkage Disequilibrium report for FCGR1B (120926908 - 120935944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FCGR1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv338n71CNV Gain21882294
    nsv10772CNV Gain18304495
    dgv337n71CNV Gain21882294
    nsv524681CNV Gain19592680
    esv26241CNV Gain+Loss19812545
    dgv94e1CNV Complex17122850
    dgv97e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FCGR1B
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGR1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601502    OMIM disorders: --


    Find genes that share disorders with FCGR1B           About GenesLikeMe

    Genetic Association Database (GAD): FCGR1B
    Human Genome Epidemiology (HuGE) Navigator: FCGR1B (3 documents)

    Export disorders for FCGR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FCGR1B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with FCGR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 2, 3 Maresco D.L.... Anderson C.L. (Cytogenet. Cell Genet. 1996)
    2. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (PubMed id 19330030)1, 4 Thomas G....Hunter D.J. (Nat. Genet. 2009)
    3. [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China]. (PubMed id 11802953)1, 4 Tang Y....Li Y. (Zhonghua Jie He He Hu Xi Za Zhi 2001)
    4. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PubMed id 9763663)1, 3 Maresco D.L....Theil K.S. (Cytogenet. Cell Genet. 1998)
    5. Novel Fc gamma receptor I family gene products in human mononuclear cells. (PubMed id 1430234)1, 2 Porges A.J....Kimberly R.P. (J. Clin. Invest. 1992)
    6. The monocyte transcriptome during pregnancy in multiple sclerosis: prominent expression of the Fc-receptor CD64. (PubMed id 21135020)1 Neuteboom R.F....Hintzen R.Q. (Mult. Scler. 2011)
    7. IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation. (PubMed id 21832933)1 Forthal D.N....Phan T. (AIDS 2011)
    8. Mechanisms of action of intravenous immunoglobulins. (PubMed id 20441428)7 Baerenwaldt A....Nimmerjahn F. (Expert Rev Clin Immunol 2010)
    9. Intravenous immunoglobulins in autoimmune and inflammatory diseases: a mechanistic perspective. (PubMed id 17911465)7 SibAcril S....Kaveri S.V. (Ann. N. Y. Acad. Sci. 2007)
    10. Intravenous immunoglobulin: an update on the clinical use and mechanisms of action. (PubMed id 17351760)7 Negi V.S....Kaveri S.V. (J. Clin. Immunol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2210 HGNC: 3614 Ensembl:ENSG00000198019 euGenes: HUgn2210 ECgene: FCGR1B
    H-InvDB: FCGR1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FCGR1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCGR1B gene:
    Search GeneIP for patents involving FCGR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FCGR1B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FCGR1B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FCGR1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for FCGR1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCGR1B   OriGene Custom Protein Services for FCGR1B  

     
     
     Block miRNA regulation of human, mouse, rat FCGR1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FCGR1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR1B Predesigned siRNA for gene silencing in human, mouse, rat FCGR1B
     QuantiFast Probe-based Assays in human, mouse, rat FCGR1B Search QuantiTect SYBR Green Assays in human, mouse, rat FCGR1B
     Custom PCR Arrays for FCGR1B Search Chromatin IP Primers for FCGR1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FCGR1B  GeneGlobe Interaction Network for FCGR1B
     Regulatory tfbs in FCGR1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for FCGR1B GenScript cDNA clones with any tag delivered in your preferred vector for FCGR1B
     GenScript Custom Assay Services for FCGR1B GenScript Custom overexpressing Cell Line Services for FCGR1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FCGR1B (FCGRB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FCGR1B lysates
     Antibodies for FCGR1B
     See all of Abcam's Antibodies, Kits and Proteins for FCGR1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FCGR1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FCGR1B
     SwitchGear Promoter luciferase reporter plasmids for FCGR1B
     ThermoFisher Antibody for FCGR1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCGR1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCGR1B
     LSBio Antibodies in human, mouse, rat for FCGR1B
     Browse compounds at ApexBio
     Search Addgene for plasmids for FCGR1B
      Search eBioscience for proteins for FCGR1B
      Search eBioscience for elisas for FCGR1B
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for FCGR1B (12 products)
     antibodies-online kits for FCGR1B
     antibodies-online peptides for FCGR1B
     antibodies-online proteins for FCGR1B
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FCGR1B gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4