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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCGR1B Gene

protein-coding   GIFtS: 47
GCID: GC01M120926

Fc Fragment Of IgG, High Affinity Ib, Receptor (CD64)

(Previous names: Fc fragment of IgG, high affinity Ib, receptor for (CD64))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fc Fragment Of IgG, High Affinity Ib, Receptor (CD64)1 2     CD64b2
Fc-Gamma RIB2 3     Fc-Gamma Receptor I B22
IgG Fc Receptor IB2 3     fcRIB2
IGFRB2 3     High Affinity Immunoglobulin Gamma Fc Receptor IB2
hFcgammaRIB2 3     FcRIB3
Fc Fragment Of IgG, High Affinity Ib, Receptor For (CD64)1     

External Ids:    HGNC: 36141   Entrez Gene: 22102   Ensembl: ENSG000001980197   OMIM: 6015025   UniProtKB: Q926373   

Export aliases for FCGR1B gene to outside databases

Previous GC identifers: GC01U990044 GC01M120729 GC01M118453


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCGR1B Gene:
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified
(Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This
gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
(provided by RefSeq, Oct 2011)

GeneCards Summary for FCGR1B Gene: 
FCGR1B (Fc fragment of IgG, high affinity Ib, receptor (CD64)) is a protein-coding gene. Diseases associated with FCGR1B include alopecia areata, and alopecia, and among its related super-pathways are Interferon Signaling and ER-Phagosome pathway. GO annotations related to this gene include IgG binding and immunoglobulin receptor activity. An important paralog of this gene is FCGR2B.

UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637
Function: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function
in the humoral immune response




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCGR1B gene promoter:
         c-Fos   HOXA9B   HOXA9   STAT1   AP-1   NF-E2 p45   Meis-1b   NF-E2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGR1B promoter sequence
   Search SABiosciences Chromatin IP Primers for FCGR1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p11.2   Ensembl cytogenetic band:  1p11.2   HGNC cytogenetic band: 1p11.2

FCGR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M120926:  view genomic region     (about GC identifiers)

Start:
120,926,908 bp from pter      End:
120,935,944 bp from pter
Size:
9,037 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637 (See protein sequence)
Recommended Name: High affinity immunoglobulin gamma Fc receptor IB precursor  
Size: 280 amino acids; 32232 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q7KZ13 Q92638
Alternative splicing: 3 isoforms:  Q92637-1   Q92637-2   Q92637-3   

Explore the universe of human proteins at neXtProt for FCGR1B: NX_Q92637

Explore proteomics data for FCGR1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92637

  • FCGR1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FCGR1B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001004340.2  NP_001017986.1  NP_001231839.1  

    ENSEMBL proteins: 
     ENSP00000358391   ENSP00000358390  
    Reactome Protein details: Q92637
    Human Recombinant Protein Products for FCGR1B: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030669clathrin-coated endocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--

    FCGR1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q92637

    ProtoNet protein and cluster: Q92637

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637
    Similarity: Belongs to the immunoglobulin superfamily. FCGR1 family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    FCGR1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGRB_HUMAN, Q92637
    Function: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function
    in the humoral immune response
    Induction: Up-regulated by IFNG/IFN-gamma

         Genatlas biochemistry entry for FCGR1B:
    immunoglobulin G,high affinity Fc receptor 1B,expressed in most cells,complexing with homodimeric gamma
    subunit,with the immunoreceptor based inhibition motif (ITIM)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019763immunoglobulin receptor activity NAS1430234
    GO:0019864IgG binding IEA--
         
    FCGR1B for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FCGR1B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    2CDK-mediated phosphorylation and removal of Cdc6
    Cross-presentation of soluble exogenous antigens (endosomes)0.81
    Antigen processing-Cross presentation0.81
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Antigen processing: Ubiquitination & Proteasome degradation
    Class I MHC mediated antigen processing & presentation0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for FCGR1B (see all 8)
        Interferon gamma signaling
    Cytokine Signaling in Immune system
    Antigen processing-Cross presentation
    Cross-presentation of soluble exogenous antigens (endosomes)
    Interferon Signaling



    FCGR1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCGR1B

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0006955immune response NAS1430234
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0038093Fc receptor signaling pathway NAS1430234

    FCGR1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCGR1B (FCGRB)

    1 DrugBank Compound for FCGR1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465

    Search CenterWatch for drugs/clinical trials and news about FCGR1B / FCGRB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCGR1B gene (3 alternative transcripts): 
    NM_001004340.3  NM_001017986.3  NM_001244910.1  

    Unigene Cluster for FCGR1B:

    Fc fragment of IgG, high affinity Ib, receptor (CD64)
    Hs.534956  [show with all ESTs]
    Unigene Representative Sequence: BC032860
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369384(uc010oxl.2 uc001eip.3 uc001eiq.3 uc009whs.2)
    ENST00000369383 ENST00000369178 ENST00000466915 ENST00000472543 ENST00000471609(uc009whr.2)

    miRNA
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    Additional mRNA sequence: 

    AK307244.1 AK308886.1 AK311502.1 BC032860.1 BC110416.1 L03419.1 L03420.1 NR_045213.1 

    10 DOTS entries:

    DT.100754131  DT.99935643  DT.121330997  DT.86850256  DT.40307395  DT.100754134  DT.114591  DT.95196944 
    DT.121372964  DT.121372988 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCGR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATATAACT
    FCGR1B Expression
    About this image


    See FCGR1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCGR1B

    SOURCE GeneReport for Unigene cluster: Hs.534956
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for FCGR1B (if available)
    TreeFam Gene Tree for FCGR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCGR1B gene
    FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  FCRL42  
    FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    10 SIMAP similar genes for FCGR1B using alignment to 1 protein entry:     FCGRB_HUMAN:
    FCGR1C    FCER1A    FCGR3B    FCGR2A    FCGR3A    Fc-gamma receptor IIIB
    FCGR2B    FCGR2C    FCRLB    FCGR1A

    FCGR1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/31 SNPs in FCGR1B are shown (see all 31)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870330511,2
    --121472551(-) CTGGTG/TGGAGT 4 -- ut51 nc-transcript-variant0--------
    rs561581341,2
    C--121472802(+) ACACCG/ACAGTG 4 -- int11Minor allele frequency- A:0.00NA 2
    rs2008396011,2
    F--121472975(-) AGAATA/GAAGAT 4 -- int11Minor allele frequency- G:0.00EU 1153
    rs2019220491,2
    C--121473890(-) GGTTAC/TGGTTT 6 I V mis1 int10--------
    rs2001535811,2
    C--121474014(-) CACCAC/TTGTCA 6 N S mis1 int11Minor allele frequency- T:0.00EU 289
    rs2017805551,2
    C--121474048(-) CTTCGC/TCCTGA 6 G syn1 int11Minor allele frequency- T:0.00EU 817
    rs2009643921,2
    C--121474109(-) TTTCCG/AGCCCT 4 -- int11Minor allele frequency- A:0.00EU 1309
    rs1998538671,2
    C,F--121474110(-) GTTTCC/TGGCCC 4 -- int11Minor allele frequency- T:0.02EU 1301
    rs2019597421,2
    C,F--121474116(-) CTTGTA/GGTTTC 4 -- int11Minor allele frequency- G:0.00EU 1233
    rs5995811,2
    C,A,H--121474217(+) GGTGAA/CACTAA 4 -- int14Minor allele frequency- C:0.00NS EA 360

    HapMap Linkage Disequilibrium report for FCGR1B (120926908 - 120935944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FCGR1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv338n71CNV Gain21882294
    nsv10772CNV Gain18304495
    dgv337n71CNV Gain21882294
    nsv524681CNV Gain19592680
    esv26241CNV Gain+Loss19812545
    dgv94e1CNV Complex17122850
    dgv97e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601502    OMIM disorders: --

    3 diseases for FCGR1B:    About MalaCards
    alopecia areata    alopecia    breast cancer


    FCGR1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FCGR1B
    Human Genome Epidemiology (HuGE) Navigator: FCGR1B (3 documents)

    Export disorders for FCGR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCGR1B gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with FCGR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 2, 3 Maresco D.L.... Anderson C.L. (1996)
    2. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (PubMed id 19330030)1, 4 Thomas G....Hunter D.J. (2009)
    3. [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China] (PubMed id 11802953)1, 4 Tang Y....Li Y. (2001)
    4. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the ev olution of human chromosome 1. (PubMed id 9763663)1, 3 Maresco D.L....Theil K.S. (1998)
    5. Novel Fc gamma receptor I family gene products in human mononuclear cells. (PubMed id 1430234)1, 2 Porges A.J....Kimberly R.P. (1992)
    6. The monocyte transcriptome during pregnancy in multip le sclerosis: prominent expression of the Fc-receptor CD64. (PubMed id 21135020)1 Neuteboom R.F....Hintzen R.Q. (2011)
    7. IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation. (PubMed id 21832933)1 Forthal D.N....Phan T. (2011)
    8. Mechanisms of action of intravenous immunoglobulins. (PubMed id 20441428)7 Baerenwaldt A....Nimmerjahn F. (2010)
    9. Intravenous immunoglobulins in autoimmune and inflamm atory diseases: a mechanistic perspective. (PubMed id 17911465)7 SibAcril S....Kaveri S.V. (2007)
    10. Intravenous immunoglobulin: an update on the clinical use and mechanisms of action. (PubMed id 17351760)7 Negi V.S....Kaveri S.V. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2210 HGNC: 3614 Ensembl:ENSG00000198019 euGenes: HUgn2210 ECgene: FCGR1B
    H-InvDB: FCGR1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCGR1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCGR1B gene:
    Search GeneIP for patents involving FCGR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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