FCGR1B Gene
protein-coding GIFtS: 49
GCID: GC01M120926
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Fc fragment of IgG, high affinity Ib, receptor (CD64)(Previous names: Fc fragment of IgG, high affinity Ib, receptor for (CD64)...)
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Aliases
for FCGR1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fc Fragment Of IgG, High Affinity Ib, Receptor (CD64)1 2 | | Fc Fragment Of IgG, High Affinity Ib, Receptor For (CD64)1 | | CD64b1 2 | | Fc-Gamma Receptor I B22 | | Fc-Gamma RIB2 3 | | FcRIB3 | | IgG Fc Receptor IB2 3 | | High Affinity Immunoglobulin Gamma Fc Receptor IB2 | | IGFRB2 3 | | FcRIB3 | | HFcgammaRIB1 | | |
Export aliases for FCGR1B gene to outside databasesPrevious GC identifers: GC01U990044 GC01M120729 GC01M118453 |
Summaries
for FCGR1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FCGR1B:
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (FcgammaRI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodesthe low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively splicedtranscript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637Function: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function inthe humoral immune response
|
Genomic Views
for FCGR1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCGR1B gene promoter:
c-Fos HOXA9B HOXA9 STAT1 AP-1 NF-E2 p45 Meis-1b NF-E2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCGR1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p11.2 Ensembl cytogenetic band: 1p11.2 HGNC cytogenetic band: 1p11.2FCGR1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M120926: view genomic region
(about GC identifiers)
Start:
|
120,926,908 bp from pter |
End:
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120,935,944 bp from pter |
Size:
|
9,037 bases |
Orientation:
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minus strand |
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Proteins
for FCGR1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637 (See
protein sequence)Recommended Name: High affinity immunoglobulin gamma Fc receptor IB precursor Size: 280 amino acids; 32232 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q7KZ13 Q92638Alternative splicing: 3 isoforms: Q92637-1 Q92637-2 Q92637-3 Explore the universe of human proteins at neXtProt for FCGR1B: NX_Q92637
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92637
FCGR1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001004340.2 NP_001017986.1 NP_001231839.1
ENSEMBL proteins: ENSP00000358391 ENSP00000358390 ENSP00000358177 Reactome Protein details: Q92637
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0009897 | external side of plasma membrane |
-- | -- | | GO:0016021 | integral to membrane |
IEA | -- | | GO:0030669 | clathrin-coated endocytic vesicle membrane |
TAS | -- | | GO:0031901 | early endosome membrane |
TAS | -- |
FCGR1B for ontologies About GeneDecksing
FCGR1B Antibody Products:
Assay Products for FCGR1B: |
Protein
Domains /
Families
for FCGR1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCGR1B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92637ProtoNet protein and cluster: Q92637 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637Similarity: Belongs to the immunoglobulin superfamily. FCGR1 familySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for FCGR1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FCGRB_HUMAN, Q92637Function: May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function inthe humoral immune responseInduction: Up-regulated by IFNG/IFN-gamma Genatlas biochemistry entry for FCGR1B:immunoglobulin G,high affinity Fc receptor 1B,expressed in most cells,complexing with homodimeric gamma subunit,withthe immunoreceptor based inhibition motif (ITIM)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR1B (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FCGR1B for ontologies About GeneDecksing
|
Pathways & Interactions
for FCGR1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytokine Signaling in Immune system | | | 2 | Immune System | | | 3 | Interferon gamma signaling | | | 4 | Ubiquitinated Orc1 is degraded by the proteasome | | | 5 | Antigen processing: Ubiquitination & Proteasome degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for FCGR1B (see all 9)
FCGR1B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCGR1B
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001788 | antibody-dependent cellular cytotoxicity |
-- | -- | | GO:0001798 | positive regulation of type IIa hypersensitivity |
-- | -- | | GO:0001805 | positive regulation of type III hypersensitivity |
-- | -- | | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS | -- |
FCGR1B for ontologies About GeneDecksing
|
Drugs & Compounds
for FCGR1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FCGR1B
1 DrugBank Compound for FCGR1B About this table
Search CenterWatch for drugs/clinical trials and news about FCGR1B / FCGRB
|
Transcripts
for FCGR1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCGR1B gene (3 alternative transcripts): NM_001004340.3 NM_001017986.3 NM_001244910.1 Unigene Cluster for FCGR1B: Fc fragment of IgG, high affinity Ib, receptor (CD64) Hs.534956 [show with all ESTs]Unigene Representative Sequence: BC0328606 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369384(uc010oxl.2 uc001eip.3 uc001eiq.3 uc009whs.2)
ENST00000369383 ENST00000369178 ENST00000466915 ENST00000472543 ENST00000471609(uc009whr.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCGR1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FCGR1B (NM_001017986) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCGR1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR1B |
Additional cDNA sequence: AK307244.1 AK308886.1 AK311502.1 BC032860.1 BC110416.1 L03419.1 L03420.1 NR_045213.1 10 DOTS entries: DT.100754131 DT.99935643 DT.121330997 DT.86850256 DT.40307395 DT.100754134 DT.114591 DT.95196944 DT.121372964 DT.121372988
GeneLoc Exon Structure
|
Expression
for FCGR1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCGR1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATATAACT
About this image
See FCGR1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCGR1B
SOURCE GeneReport for Unigene cluster: Hs.534956
SABiosciences Custom PCR Arrays for FCGR1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCGR1B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FCGR1B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGR1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1B |
Orthologs
for FCGR1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FCGR1B gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
-- |
18(a) |
1 → many |
25(1707231-1709870) |
ENSEMBL Gene Tree for FCGR1B (if available)
TreeFam Gene Tree for FCGR1B (if available) |
Paralogs
for FCGR1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCGR1B gene
- FCGR2B2 FCGR3B2 FCRL22 FCRLB2 FCRL12 FCRL42 FCRL52 FCRLA2
- FCGR1A2 FCGR2A2 FCGR3A2 FCRL32 FCER1A2 FCRL62
11 SIMAP similar genes for FCGR1B using alignment to 2 protein entries: FCGRB_HUMAN (see all proteins):FCGR1C FCER1A FCGR2B FCGR3A FCGR3B Fc-gamma receptor IIIB
FCGR2A FCGR2C FCRLB FCGR1A DKFZp686L20250
FCGR1B for paralogs About GeneDecksing
|
Genomic Variants
for FCGR1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCGR1B (120926908 - 120935944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FCGR1B
3 CNVs: 64726 30409 3309 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FCGR1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCGR1B for disorders About GeneDecksing
OMIM gene information: 601502
OMIM disorders: --
3  diseases for FCGR1B: About MalaCardsalopecia areata alopecia breast cancer
Genetic Association Database (GAD): FCGR1B
Human Genome Epidemiology (HuGE) Navigator: FCGR1B (3 documents)
Export disorders for FCGR1B gene to outside databases
|
Publications
for FCGR1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCGR1B gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with FCGR1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 2, 3 Maresco D.L.... Anderson C.L. (1996)
- [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China] (PubMed id 11802953)1, 4 Tang Y....Li Y. (2001)
- Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the ev olution of human chromosome 1. (PubMed id 9763663)1, 3 Maresco D.L....Theil K.S. (1998)
- Novel Fc gamma receptor I family gene products in human mononuclear cells. (PubMed id 1430234)1, 2 Porges A.J....Kimberly R.P. (1992)
- The monocyte transcriptome during pregnancy in multip le sclerosis: prominent expression of the Fc-receptor CD64. (PubMed id 21135020)1 Neuteboom R.F....Hintzen R.Q. (2011)
- IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation. (PubMed id 21832933)1 Forthal D.N....Phan T. (2011)
- Mechanisms of action of intravenous immunoglobulins. (PubMed id 20441428)7 Baerenwaldt A....Nimmerjahn F. (2010)
- A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (PubMed id 19330030)1 Thomas G....Hunter D.J. (2009)
- Intravenous immunoglobulins in autoimmune and inflamm atory diseases: a mechanistic perspective. (PubMed id 17911465)7 SibAcril S....Kaveri S.V. (2007)
- Intravenous immunoglobulin: an update on the clinical use and mechanisms of action. (PubMed id 17351760)7 Negi V.S....Kaveri S.V. (2007)
|
External Searches for FCGR1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCGR1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCGR1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCGR1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCGR1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCGR1B gene:
Search GeneIP for patents involving FCGR1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCGR1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCGR1B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCGR1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCGR1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCGR1B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCGR1B |
| |
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| |  |  |  |  | | | | |
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 | | | FCGR1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1B |
|  |  |  | | | | ThermoFisher Antibody for FCGR1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCGR1B |
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