Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FCGR1B Gene

Aliases for FCGR1B Gene

  • Fc Fragment Of IgG Receptor Ib 2 3
  • Fc Fragment Of IgG, High Affinity Ib, Receptor (CD64) 2 3 5
  • Fc Gamma Receptor Ib 2 3
  • IgG Fc Receptor IB 3 4
  • Fc-Gamma RIB 3 4
  • HFcgammaRIB 3 4
  • FcRIB 3 4
  • IGFRB 3 4
  • Fc Fragment Of IgG, High Affinity Ib, Receptor For (CD64) 2
  • Fc-Gamma Receptor I B2 3
  • CD64b 3

External Ids for FCGR1B Gene

Previous GeneCards Identifiers for FCGR1B Gene

  • GC01U990044
  • GC01M120729
  • GC01M120926
  • GC01M118453

Summaries for FCGR1B Gene

Entrez Gene Summary for FCGR1B Gene

  • Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for FCGR1B Gene

FCGR1B (Fc Fragment Of IgG Receptor Ib) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include IgG binding and immunoglobulin receptor activity. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR1B Gene

  • May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR1B Gene

Genomics for FCGR1B Gene

Regulatory Elements for FCGR1B Gene

Enhancers for FCGR1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FCGR1B on UCSC Golden Path with GeneCards custom track

Promoters for FCGR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FCGR1B on UCSC Golden Path with GeneCards custom track

Genomic Location for FCGR1B Gene

Chromosome:
1
Start:
121,087,345 bp from pter
End:
121,097,161 bp from pter
Size:
9,817 bases
Orientation:
Plus strand

Genomic View for FCGR1B Gene

Genes around FCGR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR1B Gene

Proteins for FCGR1B Gene

  • Protein details for FCGR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92637-FCGRB_HUMAN
    Recommended name:
    High affinity immunoglobulin gamma Fc receptor IB
    Protein Accession:
    Q92637
    Secondary Accessions:
    • Q7KZ13
    • Q92638

    Protein attributes for FCGR1B Gene

    Size:
    280 amino acids
    Molecular mass:
    32232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCGR1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR1B Gene

Proteomics data for FCGR1B Gene at MOPED

Post-translational modifications for FCGR1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FCGR1B Gene

Domains & Families for FCGR1B Gene

Gene Families for FCGR1B Gene

Protein Domains for FCGR1B Gene

Suggested Antigen Peptide Sequences for FCGR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92637

UniProtKB/Swiss-Prot:

FCGRB_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
genes like me logo Genes that share domains with FCGR1B: view

Function for FCGR1B Gene

Molecular function for FCGR1B Gene

GENATLAS Biochemistry:
immunoglobulin G,high affinity Fc receptor 1B,expressed in most cells,complexing with homodimeric gamma subunit,with the immunoreceptor based inhibition motif (ITIM)
UniProtKB/Swiss-Prot Function:
May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma.
genes like me logo Genes that share phenotypes with FCGR1B: view

Animal Model Products

CRISPR Products

miRNA for FCGR1B Gene

miRTarBase miRNAs that target FCGR1B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCGR1B Gene

Localization for FCGR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR1B Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR1B Gene COMPARTMENTS Subcellular localization image for FCGR1B gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FCGR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS,TAS --
genes like me logo Genes that share ontologies with FCGR1B: view

Pathways & Interactions for FCGR1B Gene

genes like me logo Genes that share pathways with FCGR1B: view

Interacting Proteins for FCGR1B Gene

Gene Ontology (GO) - Biological Process for FCGR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with FCGR1B: view

No data available for SIGNOR curated interactions for FCGR1B Gene

Drugs & Compounds for FCGR1B Gene

(1) Drugs for FCGR1B Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Intravenous Immunoglobulin Approved, Investigational Pharma Target, antagonist 0
genes like me logo Genes that share compounds with FCGR1B: view

Transcripts for FCGR1B Gene

mRNA/cDNA for FCGR1B Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCGR1B Gene

Fc fragment of IgG, high affinity Ib, receptor (CD64):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR1B Gene

No ASD Table

Relevant External Links for FCGR1B Gene

GeneLoc Exon Structure for
FCGR1B
ECgene alternative splicing isoforms for
FCGR1B

Expression for FCGR1B Gene

mRNA expression in normal human tissues for FCGR1B Gene

mRNA differential expression in normal tissues according to GTEx for FCGR1B Gene

This gene is overexpressed in Whole Blood (x26.2).

SOURCE GeneReport for Unigene cluster for FCGR1B Gene Hs.534956

genes like me logo Genes that share expression patterns with FCGR1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FCGR1B Gene

Orthologs for FCGR1B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCGR1A 36
  • 47 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FCGR1A 36
  • 45 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fcgr1 36
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 73 (a)
OneToMany
Species with no ortholog for FCGR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR1B Gene

ENSEMBL:
Gene Tree for FCGR1B (if available)
TreeFam:
Gene Tree for FCGR1B (if available)

Paralogs for FCGR1B Gene

(10) SIMAP similar genes for FCGR1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FCGR1B: view

Variants for FCGR1B Gene

Sequence variations from dbSNP and Humsavar for FCGR1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs667861 -- 121,089,027(-) CACTA(C/T)GTACC intron-variant
rs827371 -- 121,087,628(-) CACTG(A/C/G/T)GGTGT intron-variant
rs1072997 -- 121,092,521(-) TGCCA(C/T)GCCAG intron-variant
rs1509893 -- 121,089,851(+) ACTTC(G/T)TTAAA intron-variant
rs1769949 -- 121,095,294(-) acccc(C/T)ccttc intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FCGR1B Gene

Variant ID Type Subtype PubMed ID
nsv524681 CNV Gain 19592680
dgv94e1 CNV Complex 17122850
dgv97e1 CNV Complex 17122850
esv26241 CNV Gain+Loss 19812545
dgv337n71 CNV Gain 21882294
dgv338n71 CNV Gain 21882294
nsv10772 CNV Gain 18304495

Variation tolerance for FCGR1B Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FCGR1B Gene

Disorders for FCGR1B Gene

Relevant External Links for FCGR1B

Genetic Association Database (GAD)
FCGR1B
Human Genome Epidemiology (HuGE) Navigator
FCGR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR1B

No disorders were found for FCGR1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCGR1B Gene

Publications for FCGR1B Gene

  1. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco D.L. … Anderson C.L. (Cytogenet. Cell Genet. 1996) 2 3 4 67
  2. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco D.L. … Theil K.S. (Cytogenet. Cell Genet. 1998) 2 3
  3. The monocyte transcriptome during pregnancy in multiple sclerosis: prominent expression of the Fc-receptor CD64. (PMID: 21135020) Neuteboom R.F. … Hintzen R.Q. (Mult. Scler. 2011) 3
  4. IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation. (PMID: 21832933) Forthal D.N. … Phan T. (AIDS 2011) 3
  5. Mechanisms of action of intravenous immunoglobulins. (PMID: 20441428) Baerenwaldt A. … Nimmerjahn F. (Expert Rev Clin Immunol 2010) 25

Products for FCGR1B Gene

Sources for FCGR1B Gene

Content