Aliases for FCGR1B Gene
Aliases for FCGR1B Gene
External Ids for FCGR1B Gene
- HGNC: 3614
- Entrez Gene: 2210
- Ensembl: ENSG00000198019
- OMIM: 601502
- UniProtKB: Q92637
Previous GeneCards Identifiers for FCGR1B Gene
- GC01U990044
- GC01M120729
- GC01M120926
- GC01M118453
Summaries for FCGR1B Gene
-
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for FCGR1B Gene
FCGR1B (Fc Fragment Of IgG Receptor Ib) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include IgG binding and immunoglobulin receptor activity. An important paralog of this gene is FCGR1A.
UniProtKB/Swiss-Prot for FCGR1B Gene
-
May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR1B Gene
Genomics for FCGR1B Gene
Regulatory Elements for FCGR1B Gene
Enhancers for FCGR1B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G120088 | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 1.7 | -999.1 | -999051 | 0.6 | ZNF146 ZNF600 FOS | NOTCH2 ZNF697 FCGR1B LOC105378939 LOC101929178 |
| GH01G121086 | 0.2 | Ensembl | 0.7 | +1.4 | 1356 | 3.8 | FCGR1B LOC100996318 | |
| GH01G121080 | 0.2 | Ensembl | 0.4 | -6.7 | -6683 | 1.1 | FCGR1B LOC100996722 | |
| GH01G121091 | 0.2 | Ensembl | 0.4 | +5.4 | 5356 | 1.8 | FCGR1B LOC100996318 | |
| GH01G121075 | 0.2 | Ensembl | 0.4 | -12.0 | -12045 | 0.2 | FCGR1B LOC100996722 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCGR1B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FCGR1B Gene
- Chromosome:
- 1
- Start:
- 121,087,345 bp from pter
- End:
- 121,097,161 bp from pter
- Size:
- 9,817 bases
- Orientation:
- Plus strand
Genomic View for FCGR1B Gene
Genes around FCGR1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p11.2 by Ensembl
- 1p11.2 by Entrez Gene
- 1p11.2 by HGNC
FCGR1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCGR1B Gene
Proteins for FCGR1B Gene
-
Protein details for FCGR1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92637-FCGRB_HUMAN
- Recommended name:
- High affinity immunoglobulin gamma Fc receptor IB
- Protein Accession:
- Q92637
- Q7KZ13
- Q92638
Protein attributes for FCGR1B Gene
- Size:
- 280 amino acids
- Molecular mass:
- 32232 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for FCGR1B Gene
Other Protein References for FCGR1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FCGR1B
-
Abcam antibodies for FCGR1B
- Invitrogen Antibodies for FCGR1B
- antibodies-online Antibodies for FCGR1B: See all 22
- GeneTex FCGR1B antibody for FCGR1B
Protein Products
-
OriGene Purified Proteins for FCGR1B
- Search Origene for MassSpec and Protein Over-expression Lysates for FCGR1B
- Origene Custom Protein Services for FCGR1B
- Novus Biologicals lysates for FCGR1B
- Search GeneTex for Proteins for FCGR1B
Assay Products
No data available for DME Specific Peptides for FCGR1B Gene
Domains & Families for FCGR1B Gene
Gene Families for FCGR1B Gene
Protein Domains for FCGR1B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCGR1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92637- Family:
-
- Belongs to the immunoglobulin superfamily. FCGR1 family.
Function for FCGR1B Gene
Molecular function for FCGR1B Gene
- GENATLAS Biochemistry:
- immunoglobulin G,high affinity Fc receptor 1B,expressed in most cells,complexing with homodimeric gamma subunit,with the immunoreceptor based inhibition motif (ITIM)
- UniProtKB/Swiss-Prot Function:
- May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFNG/IFN-gamma.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019763 | immunoglobulin receptor activity | NAS | 1430234 |
| GO:0019864 | IgG binding | IEA | -- |
Phenotypes for FCGR1B Gene
- GenomeRNAi human phenotypes for FCGR1B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FCGR1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGR1B gene
- Search ViGene Biosciences for FCGR1B
CRISPR Products
-
OriGene CRISPR knockouts for FCGR1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCGR1B
- GenScript: Design CRISPR guide RNA sequences for FCGR1B
miRNA for FCGR1B Gene
- miRTarBase miRNAs that target FCGR1B
miRNA Products
- Search ViGene Biosciences for FCGR1B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCGR1B
- Browse OriGene Inhibitory RNA Products For FCGR1B
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGR1B gene
Cell Line Products
-
Horizon Cell Lines for FCGR1B
-
ViGene Biosciences adenoviral particle packaged cDNA for FCGR1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCGR1B gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCGR1B Gene
Localization for FCGR1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCGR1B Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 4 |
| extracellular | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | TAS | -- |
| GO:0031901 | early endosome membrane | TAS | -- |
Pathways & Interactions for FCGR1B Gene
Pathways by source for FCGR1B Gene
Interacting Proteins for FCGR1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006898 | receptor-mediated endocytosis | TAS | -- |
| GO:0006955 | immune response | NAS | 1430234 |
No data available for SIGNOR curated interactions for FCGR1B Gene
Drugs & Compounds for FCGR1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Immune Globulin Human | Approved, Investigational | Pharma | Target, antagonist | 0 |
Transcripts for FCGR1B Gene
mRNA/cDNA for FCGR1B Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCGR1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for FCGR1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCGR1B
- GenScript: Design CRISPR guide RNA sequences for FCGR1B
miRNA Products
- Search ViGene Biosciences for FCGR1B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCGR1B
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-
ViGene Biosciences ready-to-package AAV shRNAs for FCGR1B gene
Flow Cytometry Products
Expression for FCGR1B Gene
mRNA differential expression in normal tissues according to GTEx for FCGR1B Gene
This gene is overexpressed in Whole Blood (x26.2).
NURSA nuclear receptor signaling pathways regulating expression of FCGR1B Gene:
FCGR1BSOURCE GeneReport for Unigene cluster for FCGR1B Gene:
Hs.534956Evidence on tissue expression from TISSUES for FCGR1B Gene
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for FCGR1B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR1B Gene
Orthologs for FCGR1B Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | FCGR1A 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | FCGR1A 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Fcgr1 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for FCGR1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCGR1B Gene
Paralogs for FCGR1B Gene
(10) SIMAP similar genes for FCGR1B Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for FCGR1B Gene
Variants for FCGR1B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1072997 | -- | 121,092,521(-) | TGCCA(C/T)GCCAG | intron-variant, utr-variant-3-prime | |
| rs112039946 | -- | 121,095,044(-) | TGTCT(A/G)GGCCA | intron-variant, utr-variant-3-prime | |
| rs112077231 | -- | 121,089,783(-) | TTGAA(A/T)GAAGC | intron-variant | |
| rs112381405 | -- | 121,091,093(-) | ACCAA(A/G)AATGT | intron-variant, utr-variant-3-prime | |
| rs112526521 | -- | 121,096,991(-) | AACCA(A/G)AAAAT | nc-transcript-variant, utr-variant-3-prime |
Residual Variation Intolerance Score:
86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.49;
77.57% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCGR1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCGR1B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR1B Gene
Disorders for FCGR1B Gene
Relevant External Links for FCGR1B
No disorders were found for FCGR1B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCGR1B Gene
Publications for FCGR1B Gene
- The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco D.L. … Anderson C.L. (Cytogenet. Cell Genet. 1996) 2 3 4 64
- A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (PMID: 19330030) Thomas G. … Hunter D.J. (Nat. Genet. 2009) 3 46 64
- [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China]. (PMID: 11802953) Tang Y. … Li Y. (Zhonghua Jie He He Hu Xi Za Zhi 2001) 3 46 64
- Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco D.L. … Theil K.S. (Cytogenet. Cell Genet. 1998) 2 3 64
- Novel Fc gamma receptor I family gene products in human mononuclear cells. (PMID: 1430234) Porges A.J. … Kimberly R.P. (J. Clin. Invest. 1992) 3 4 64
Products for FCGR1B Gene
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- Custom Antibody ServicesOriGene Antibodies for FCGR1B
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCGR1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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- (88) miRTarBase
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- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
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- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (146) Cyagen
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer