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FCGR1A Gene

protein-coding   GIFtS: 65
GCID: GC01P149754

Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64)

(Previous names: Fc fragment of IgG, high affinity Ia, receptor for (CD64))
  See FCGR1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64)1 2     Fc Gamma Receptor2
IGFR12 3 5     Fc-Gamma Receptor I A12
Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64)1 2     fcgammaRIa2
Fc-Gamma RIA2 3     High Affinity Immunoglobulin Gamma Fc Receptor I2
Fc-Gamma RI2 3     FCG13
IgG Fc Receptor I2 3     FCGR13
CD642 5     FcRI3
CD64A2     FcgammaRIa3
FCRI2     CD64 Antigen3

External Ids:    HGNC: 36131   Entrez Gene: 22092   Ensembl: ENSG000001503377   OMIM: 1467605   UniProtKB: P123143   

Export aliases for FCGR1A gene to outside databases

Previous GC identifers: GC01P147395 GC01P141381 GC01P146529 GC01P146970 GC01P146567 GC01P148020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCGR1A Gene:
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity
Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. (provided by
RefSeq, Jul 2008)

GeneCards Summary for FCGR1A Gene:
FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64)) is a protein-coding gene. Diseases associated with FCGR1A include pharyngitis, and peritonitis. GO annotations related to this gene include IgG binding and receptor signaling protein activity. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314
Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive
immune responses

Gene Wiki entry for FCGR1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGR1A gene promoter:
         HOXA9B   HOXA9   STAT1   p53   STAT1beta   HNF-3beta   Meis-1b   STAT1alpha   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGR1A promoter sequence
   Search Chromatin IP Primers for FCGR1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2-q21.3   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2-q21.3

FCGR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149754:  view genomic region     (about GC identifiers)

Start:
149,754,227 bp from pter      End:
149,764,074 bp from pter
Size:
9,848 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314 (See protein sequence)
Recommended Name: High affinity immunoglobulin gamma Fc receptor I precursor  
Size: 374 amino acids; 42632 Da
Subunit: Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A
degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN
1 PDB 3D structure from and Proteopedia for FCGR1A:
3RJD (3D)    
Secondary accessions: P12315 Q5QNW7 Q92495 Q92663
Alternative splicing: 2 isoforms:  P12314-1   P12314-2   

Explore the universe of human proteins at neXtProt for FCGR1A: NX_P12314

Explore proteomics data for FCGR1A at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues (By similarity)1
  • Glycosylation2 at Asn59, Asn78, Asn152, Asn159, Asn163, Asn195, Asn240
  • Modification sites at PhosphoSitePlus

  • See FCGR1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000557.1  
    ENSEMBL proteins: 
     ENSP00000394279   ENSP00000358165  
    Reactome Protein details: P12314

    FCGR1A Human Recombinant Protein Products:

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    Novus Biologicals FCGR1A Proteins
    Novus Biologicals FCGR1A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FCGR1A 

     
    antibodies-online proteins for FCGR1A (7 products) 

     
    antibodies-online peptides for FCGR1A

    FCGR1A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FCGR1A
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    Browse Antibodies at Cloud-Clone Corp.
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    antibodies-online antibodies for FCGR1A (123 products) 

    FCGR1A Assay Products:

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    antibodies-online kits for FCGR1A (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P12314

    ProtoNet protein and cluster: P12314

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314
    Similarity: Belongs to the immunoglobulin superfamily. FCGR1 family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCGR1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGR1_HUMAN, P12314
    Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive
    immune responses

         Genatlas biochemistry entry for FCGR1A:
    immunoglobulin G,high affinity Fc receptor 1A,expressed by macrophages,monocytes,neutrophils

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS10879688
    GO:0005515protein binding IPI18322202
    GO:0019864IgG binding IEA--
         
    Find genes that share ontologies with FCGR1A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FCGR1A:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fcgr1):
     cellular  hematopoietic system  immune system  normal  skeleton 

    Find genes that share phenotypes with FCGR1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FCGR1A: Fcgr1tm1Hoga Fcgr1tm1Jgjw Fcgr1tm1Sjv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCGR1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCGR1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCGR1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCGR1A

    miRNA
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    Block miRNA regulation of human, mouse, rat FCGR1A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FCGR1A:
    hsa-miR-642a hsa-miR-4328 hsa-miR-1303 hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidFCGR1A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FCGR1A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: FCGR1A (NM_000566)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCGR1_HUMAN, P12314: Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane
    through interaction with FCER1G
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030669clathrin-coated endocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--

    Find genes that share ontologies with FCGR1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCGR1A About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    3CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Cross-presentation of soluble exogenous antigens (endosomes)0.80
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    5Creation of C4 and C2 activators
    FCGR activation0.54
    Role of phospholipids in phagocytosis0.53


    Find genes that share SuperPaths with FCGR1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FCGR1A
        Fc-GammaR Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages
    NFAT in Immune Response
    Phagocytosis of Microbes

    5 Reactome Pathways for FCGR1A
        Interferon gamma signaling
    Regulation of actin dynamics for phagocytic cup formation
    FCGR activation
    Cross-presentation of soluble exogenous antigens (endosomes)
    Role of phospholipids in phagocytosis


    Selected Kegg Pathways  (Kegg details for FCGR1A) (see all 9):
        Phagosome
    Osteoclast differentiation
    Hematopoietic cell lineage
    Fc gamma R-mediated phagocytosis
    Leishmaniasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FCGR1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Antifungal Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FCGR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FCGR1A (P123142, 3 ENSP000003581654) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130942, 3, ENSP000000467944MINT-17488 I2D: score=1 STRING: ENSP00000046794
    SHC1P293532, 3, ENSP000004013034MINT-15946 I2D: score=1 STRING: ENSP00000401303
    CBLP226812, 3, ENSP000002640334MINT-17062 I2D: score=1 STRING: ENSP00000264033
    CRKLP461093, ENSP000003463004I2D: score=3 STRING: ENSP00000346300
    HCKP086313, ENSP000003650124I2D: score=3 STRING: ENSP00000365012
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0006911phagocytosis, engulfment TAS10879688
    GO:0006955immune response TAS10879688
    GO:0007165signal transduction TAS10879688

    Find genes that share ontologies with FCGR1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGR1A (FCGR1)

    Selected DrugBank Compounds for FCGR1A (see all 21)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    TrastuzumabAnti HER2 (see all 2)180288-69-1target--9435876 17016423 17139284
    Abciximab7E3 (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Alemtuzumab-- 216503-57-0target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423
    EtanerceptCD120b (see all 7)185243-69-0target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for FCGR1A gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 46.6 53 8993005 (4), 7859733 (4), 7705403 (3), 7995951 (3) (see all 25)
    herbimycin a 37.4 1 10979209 (1)
    fmlp 34.3 4 1370419 (1), 1431552 (1)
    latex 29.3 1 9973503 (1)
    genistein 29.2 2 7927687 (1), 10979209 (1)
    exotoxin-a 27.3 1 9657258 (1)
    superoxide 27.2 5 9266281 (2), 7594506 (1), 18621373 (1)
    cycloheximide 27.1 5 1834666 (1), 8956369 (1), 2141616 (1), 7565811 (1)
    zymosan 26.7 1 7957310 (1)
    digitonin 20.1 1 8415618 (1)



    Find genes that share compounds with FCGR1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCGR1A gene: 
    NM_000566.3  

    Unigene Cluster for FCGR1A:

    Fc fragment of IgG, high affinity Ia, receptor (CD64)
    Hs.77424  [show with all ESTs]
    Unigene Representative Sequence: NM_000566
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444948 ENST00000369168(uc009wlh.1 uc001esp.4) ENST00000489479
    ENST00000489704
    miRNA
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    hsa-miR-642a hsa-miR-4328 hsa-miR-1303 hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidFCGR1A 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FCGR1A
      QuantiTect SYBR Green Assays in human, mouse, rat FCGR1A
      QuantiFast Probe-based Assays in human, mouse, rat FCGR1A

    Additional mRNA sequence: 

    AK291451.1 AK291502.1 BC032634.1 BC152383.1 DQ786309.1 L03418.1 X14355.1 X14356.1 

    11 DOTS entries:

    DT.114591  DT.121372964  DT.95375845  DT.100754132  DT.92422747  DT.121372981  DT.100754131  DT.121330997 
    DT.121372818  DT.121372988  DT.99989558 

    Selected AceView cDNA sequences (see all 66):

    CR591922 CD677475 NM_000566 CR608315 AI825678 F08275 AL543551 CR622515 
    BI823671 BQ002319 L03418 BX952705 BM699171 AI886388 AW014990 BC032634 
    BI769033 BV204029 BG621147 AW613285 AW862023 AW592667 AA873178 CB987743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCGR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATGTAACT
    FCGR1A Expression
    About this image


    FCGR1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Macrophages Peripheral Blood
             bone marrow-derived macrophages   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    FCGR1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGR1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77424

    UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314
    Tissue specificity: Monocyte/macrophage specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FCGR1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Antifungal Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FCGR1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCGR1A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgr11 , 5 Fc receptor, IgG, high affinity I1, 5 78.17(n)1
    70.76(a)1
      3 (41.72 cM)5
    141291  NM_010186.51  NP_034316.11 
     962829095 


    ENSEMBL Gene Tree for FCGR1A (if available)
    TreeFam Gene Tree for FCGR1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCGR1A gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  
    FCRL42  FCGR2A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    15 SIMAP similar genes for FCGR1A using alignment to 2 protein entries:     FCGR1_HUMAN (see all proteins):
    FCER1A    FCRLA    FCGR2A    FCGR2C    FCGR3A    FCGR3B
    Fc-gamma receptor IIIB    FCGR2B    FCRL2    FCRL6    FCRL5    FCGR1B
    FCGR1C    FCRL3    FCRLB

    Find genes that share paralogs with FCGR1A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FCGR1A
    PGOHUM00000251071


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCGR1A (see all 26)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562261871,2
    C,F--149752366(+) GAATCG/ACAAGG 1 -- us2k12Minor allele frequency- A:0.37NA 8
    rs1412364911,2
    C--149752408(+) GAGTAC/TGTAAA 1 -- us2k10--------
    rs1385699401,2
    C--149752455(+) TTTTTC/TACAAC 1 -- us2k10--------
    rs802424221,2
    C,F--149752587(+) CTGGCA/TTGTAA 1 -- us2k11Minor allele frequency- T:0.33NA 6
    rs1408071971,2
    C--149752950(+) CTCTCA/GTCTCT 1 -- us2k10--------
    rs1822347631,2
    --149753099(+) CAGGTA/GAGGCA 1 -- us2k10--------
    rs6080741,2
    C,A,H--149753106(+) GGCAGC/GTCTGC 1 -- us2k12Minor allele frequency- G:0.00NA 4
    rs6638511,2
    C,F,A,H--149753145(+) GTTTCG/ACACTG 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs21039141,2
    C,A,H--149753149(+) CGCACG/TGTGGC 1 -- us2k10--------
    rs6089601,2
    F,H--149753325(+) AGAGAC/TATACC 1 -- us2k16Minor allele frequency- T:0.01NS EA NA 416

    HapMap Linkage Disequilibrium report for FCGR1A (149754227 - 149764074 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCGR1A (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469694CNV Loss16826518
    nsv428235CNV Gain18775914
    nsv872414CNV Gain21882294
    esv21909CNV Gain19812545
    nsv470736CNV Gain18288195
    esv2750807CNV Gain17911159
    nsv831525CNV Gain17160897
    nsv872384CNV Gain21882294
    nsv824564CNV Gain20364138
    nsv831503CNV Gain17160897

    Human Gene Mutation Database (HGMD): FCGR1A
    Locus Specific Mutation Databases (LSDB): FCGR1A

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146760    OMIM disorders: --

    3 diseases for FCGR1A:    
    About MalaCards
    pharyngitis    peritonitis    sepsis


    Find genes that share disorders with FCGR1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FCGR1A gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antibody-dependent enhancement 63.1 1 1976824 (1)
    purpura thrombocytopenic 34.7 2 9435876 (1), 8616043 (1)
    bacterial infections 31.4 16 17577814 (6), 16028647 (2), 16308225 (2), 12558136 (2) (see all 7)
    myeloma 15.2 1 16818279 (1)
    necrosis 14.1 4 11095999 (1), 11211151 (1), 1837029 (1), 2137489 (1)
    tumors 12.1 27 19153117 (3), 12516969 (2), 10820252 (2), 20078550 (2) (see all 19)
    lupus erythematosus systemic 11 3 7481565 (1), 7973454 (1), 14728877 (1)
    rheumatoid arthritis 10.5 2 9227327 (2)
    acute leukemia 7.84 4 16403274 (1), 14679004 (1)
    shock septic 7.15 4 11797018 (4)

    Genetic Association Database (GAD): FCGR1A
    Human Genome Epidemiology (HuGE) Navigator: FCGR1A (5 documents)

    Export disorders for FCGR1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCGR1A gene, integrated from 10 sources (see all 361):
    (articles sorted by number of sources associating them with FCGR1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. (PubMed id 8064233)1, 2, 9 Wang A.V.... Geha R.S. (J. Exp. Med. 1994)
    2. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 3, 9 Maresco D.L.... Anderson C.L. (Cytogenet. Cell Genet. 1996)
    3. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PubMed id 1379234)1, 2, 9 Ernst L.K.... Anderson C.L. (J. Biol. Chem. 1992)
    4. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PubMed id 9763663)1, 3, 9 Maresco D.L....Theil K.S. (Cytogenet. Cell Genet. 1998)
    5. Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding. (PubMed id 21965667)1, 2 Lu J.... Sun P.D. (J. Biol. Chem. 2011)
    6. Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer. (PubMed id 20418097)1, 4 Pander J....Guchelaar H.J. (Eur. J. Cancer 2010)
    7. Association of interleukin-1 receptor antagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method. (PubMed id 18321309)1, 4 Komatsu Y....Yoshie H. (Int. J. Immunogenet. 2008)
    8. Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing. (PubMed id 18322202)1, 2 Beekman J.M....Leusen J.H.W. (J. Immunol. 2008)
    9. Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail. (PubMed id 18023480)1, 2 Beekman J.M.... Leusen J.H.W. (Mol. Immunol. 2008)
    10. Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity. (PubMed id 15229321)1, 2 Beekman J.M.... Leusen J.H.W. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2209 HGNC: 3613 AceView: FCGR1A Ensembl:ENSG00000150337 euGenes: HUgn2209
    ECgene: FCGR1A Kegg: 2209 H-InvDB: FCGR1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCGR1A Pharmacogenomics, SNPs, Pathways
    FCGR1Abasehttp://bioinf.uta.fi/FCGR1Abase/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCGR1A gene:
    Search GeneIP for patents involving FCGR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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