Aliases for FCGR1A Gene
Aliases for FCGR1A Gene
External Ids for FCGR1A Gene
- HGNC: 3613
- Entrez Gene: 2209
- Ensembl: ENSG00000150337
- OMIM: 146760
- UniProtKB: P12314
Previous GeneCards Identifiers for FCGR1A Gene
- GC01P147395
- GC01P141381
- GC01P146529
- GC01P146970
- GC01P146567
- GC01P148020
Summaries for FCGR1A Gene
-
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for FCGR1A Gene
FCGR1A (Fc Fragment Of IgG Receptor Ia) is a Protein Coding gene. Diseases associated with FCGR1A include Cervical Adenitis and Tetrasomy 21. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Toxoplasmosis. GO annotations related to this gene include signal transducer activity, downstream of receptor and IgG binding. An important paralog of this gene is FCGR1B.
UniProtKB/Swiss-Prot for FCGR1A Gene
-
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR1A Gene
Genomics for FCGR1A Gene
Regulatory Elements for FCGR1A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G149746 | 0.7 | Ensembl ENCODE | 8 | -34.3 | -34342 | 0.7 | CHD1 ZBTB33 EZH2 | LOC102723955 FCGR1A TRN-GTT8-1 GC01M149741 |
| GH01G149792 | 0.8 | ENCODE | 0.4 | +11.4 | 11402 | 1.2 | GTF2F1 CTCF MXI1 ATF1 RB1 SIN3A UBTF ZIC2 RAD21 CTBP1 | SV2A ENSG00000233030 FCGR1A |
| GH01G149775 | 0.8 | Ensembl | 0.4 | -5.4 | -5353 | 1.0 | HDAC1 PKNOX1 NFRKB EGR1 CEBPB HDAC8 ZNF592 POLR2H MEF2D NFIC | SV2A FCGR1A TRR-CCT8-1 |
| GH01G149787 | 0.8 | Ensembl ENCODE | 0.4 | +6.9 | 6926 | 1.6 | JUND ATF3 IKZF1 KDM1A SPI1 | ENSG00000233030 FCGR1A |
| GH01G149768 | 0.5 | Ensembl | 0.4 | -11.9 | -11875 | 1.2 | ELK1 SREBF2 SIN3A ZBTB33 | TRR-CCT8-1 FCGR1A |
- Transcription factor binding sites by QIAGEN in the FCGR1A gene promoter:
Regulatory Element Products
Genomic Location for FCGR1A Gene
- Chromosome:
- 1
- Start:
- 149,781,275 bp from pter
- End:
- 149,792,518 bp from pter
- Size:
- 11,244 bases
- Orientation:
- Plus strand
Genomic View for FCGR1A Gene
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCGR1A Gene
Proteins for FCGR1A Gene
-
Protein details for FCGR1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12314-FCGR1_HUMAN
- Recommended name:
- High affinity immunoglobulin gamma Fc receptor I
- Protein Accession:
- P12314
- P12315
- Q5QNW7
- Q92495
- Q92663
Protein attributes for FCGR1A Gene
- Size:
- 374 amino acids
- Molecular mass:
- 42632 Da
- Quaternary structure:
-
- Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.
Three dimensional structures from OCA and Proteopedia for FCGR1A Gene
Protein Expression for FCGR1A Gene
Post-translational modifications for FCGR1A Gene
- Phosphorylated on serine residues.
- Glycosylation at Asn59, Asn78, Asn152, Asn159, Asn163, Asn195, and isoforms=2240
- Modification sites at PhosphoSitePlus
Other Protein References for FCGR1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FCGR1A
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-
Custom Antibody ServicesOriGene Antibodies for FCGR1A
- AM50348PU-S
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- TA506351JM
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- TA506351FM
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- TA506343S
- TA506343JM
- TA506343HM
- TA506343GM
- TA506343FM
- TA506343EM
- TA506343DM
- TA506343CM
- TA506343BM
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- TA506331JM
- TA506331HM
- TA506331GM
- TA506331FM
- TA506331EM
- TA506331DM
- TA506331CM
- TA506331BM
- TA506331AM
- UM570062
- UM500062
- CF506351
- TA506351
- CF506345
- TA506345
- CF506344
- TA506344
- CF506343
- TA506343
- CF506331
- TA506331
- TA352787
- TA352566
- TA343349
- TA326989
- TA320330
- SM1152PT
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- SM1152LE
- SM1152FT
- SM1152F
- Novus Biologicals Antibodies for FCGR1A
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Abcam antibodies for FCGR1A
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- antibodies-online Antibodies for FCGR1A: See all 242
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Santa Cruz Biotechnology (SCBT) Antibodies for FCGR1A
Protein Products
- R&D Systems Proteins and Enzymes for FCGR1A (Fc gamma RI/CD64)
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Cloud-Clone Corp. Proteins for FCGR1A
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ProSci Proteins for FCGR1A
-
Abcam proteins for FCGR1A
No data available for DME Specific Peptides for FCGR1A Gene
Domains & Families for FCGR1A Gene
Gene Families for FCGR1A Gene
Protein Domains for FCGR1A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCGR1A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P12314- Family:
-
- Belongs to the immunoglobulin superfamily. FCGR1 family.
Function for FCGR1A Gene
Molecular function for FCGR1A Gene
- GENATLAS Biochemistry:
- immunoglobulin G,high affinity Fc receptor 1A,expressed by macrophages,monocytes,neutrophils
- UniProtKB/Swiss-Prot Function:
- High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005057 | signal transducer activity, downstream of receptor | TAS | 10879688 |
| GO:0005515 | protein binding | IPI | 18322202 |
| GO:0019864 | IgG binding | IEA | -- |
Phenotypes for FCGR1A Gene
- MGI mutant phenotypes for FCGR1A:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FCGR1A:
Animal Model Products
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CRISPR Products
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miRNA for FCGR1A Gene
- miRTarBase miRNAs that target FCGR1A
miRNA Products
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Inhibitory RNA Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGR1A Gene
Localization for FCGR1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCGR1A Gene
- Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | TAS | -- |
| GO:0031901 | early endosome membrane | TAS | -- |
Pathways & Interactions for FCGR1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Regulation of actin dynamics for phagocytic cup formation | ||
| 3 | Role of phospholipids in phagocytosis |
.39
|
|
| 4 | Innate Immune System |
.61
|
|
| 5 | Interferon gamma signaling | ||
Pathways by source for FCGR1A Gene
14 Reactome pathways for FCGR1A Gene
9 KEGG pathways for FCGR1A Gene
4 Qiagen pathways for FCGR1A Gene
Interacting Proteins for FCGR1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0006898 | receptor-mediated endocytosis | TAS | -- |
| GO:0006911 | phagocytosis, engulfment | TAS | 10879688 |
| GO:0006955 | immune response | TAS | 10879688 |
| GO:0007165 | signal transduction | TAS | 10879688 |
No data available for SIGNOR curated interactions for FCGR1A Gene
Drugs & Compounds for FCGR1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Abciximab | Approved | Pharma | Target | 65 | ||
| Adalimumab | Approved | Pharma | Target | 494 | ||
| Alefacept | Approved, Withdrawn | Pharma | Target | 40 | ||
| alemtuzumab | Approved, Investigational | Pharma | Target | Therapeutic Antibodies | 310 | |
| Basiliximab | Approved, Investigational | Pharma | Target | 138 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FCGR1A Gene
mRNA/cDNA for FCGR1A Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (66) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCGR1A Gene
CRISPR Products
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miRNA Products
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Inhibitory RNA Products
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Expression for FCGR1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Macrophages Peripheral Blood
- bone marrow-derived macrophages
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
mRNA differential expression in normal tissues according to GTEx for FCGR1A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR1A Gene
NURSA nuclear receptor signaling pathways regulating expression of FCGR1A Gene:
FCGR1ASOURCE GeneReport for Unigene cluster for FCGR1A Gene:
Hs.77424mRNA Expression by UniProt/SwissProt for FCGR1A Gene:
P12314-FCGR1_HUMANEvidence on tissue expression from TISSUES for FCGR1A Gene
- Blood(4.6)
- Liver(4.2)
- Lymph node(2.6)
- Bone marrow(2.4)
- Spleen(2.3)
- Intestine(2.2)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for FCGR1A
-
OriGene qPCR primer pairs and template standards for FCGR1A
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR1A Gene
Orthologs for FCGR1A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToMany | |
| FCGR1A 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | FCGR1A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCGR1A 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcgr1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcgr1a 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for FCGR1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCGR1A Gene
Paralogs for FCGR1A Gene
(15) SIMAP similar genes for FCGR1A Gene using alignment to 2 proteins:
Variants for FCGR1A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs74315310 | Pathogenic | 149,784,224(+) | CAGGG(C/T)GAAGT | intron-variant, reference, stop-gained | |
| rs1050191 | -- | 149,784,109(+) | AGCTC(C/T)ACACA | intron-variant, reference, synonymous-codon | |
| rs1050204 | -- | 149,791,362(+) | AGTGG(A/G)ATTTA | intron-variant, upstream-variant-2KB, reference, missense | |
| rs1050212 | -- | 149,791,635(+) | GGTAT(A/G)TAACT | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs10670379 | -- | 149,785,423(+) | TTTTT(-/T)GAGAC | intron-variant |
Relevant External Links for FCGR1A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR1A Gene
Disorders for FCGR1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cervical adenitis |
|
|
| tetrasomy 21 |
|
|
| pharyngitis |
|
|
| specific bursitis often of occupational origin |
|
|
| cerebral neuroblastoma |
|
|
Relevant External Links for FCGR1A
No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR1A Gene
Publications for FCGR1A Gene
- Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco D.L. … Theil K.S. (Cytogenet. Cell Genet. 1998) 2 3 22 64
- The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco D.L. … Anderson C.L. (Cytogenet. Cell Genet. 1996) 2 3 22 64
- Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. (PMID: 8064233) Wang A.V. … Geha R.S. (J. Exp. Med. 1994) 3 4 22 64
- Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PMID: 1379234) Ernst L.K. … Anderson C.L. (J. Biol. Chem. 1992) 3 4 22 64
- Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding. (PMID: 21965667) Lu J. … Sun P.D. (J. Biol. Chem. 2011) 3 4 64
Products for FCGR1A Gene
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- AM05198RP-N
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- TA320330
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- TA506331
- CF506331
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- UM500062
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCGR1A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




