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Aliases for FCGR1A Gene

Aliases for FCGR1A Gene

  • Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64) 2 3
  • Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64) 2 3
  • IgG Fc Receptor I 3 4
  • Fc-Gamma RIA 3 4
  • Fc-Gamma RI 3 4
  • FcgammaRIa 3 4
  • IGFR1 3 4
  • FCRI 3 4
  • Fc-Gamma Receptor I A1 3
  • Fc Gamma Receptor 3
  • CD64 Antigen 4
  • CD64A 3
  • FCGR1 4
  • CD64 3
  • FCG1 4

External Ids for FCGR1A Gene

Previous GeneCards Identifiers for FCGR1A Gene

  • GC01P147395
  • GC01P141381
  • GC01P146529
  • GC01P146970
  • GC01P146567
  • GC01P148020

Summaries for FCGR1A Gene

Entrez Gene Summary for FCGR1A Gene

  • This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCGR1A Gene

FCGR1A (Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64)) is a Protein Coding gene. Diseases associated with FCGR1A include cervical adenitis and tetrasomy 21. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor signaling protein activity and IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR1A Gene

  • High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Gene Wiki entry for FCGR1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR1A Gene

Genomics for FCGR1A Gene

Regulatory Elements for FCGR1A Gene

Genomic Location for FCGR1A Gene

Chromosome:
1
Start:
149,781,275 bp from pter
End:
149,792,518 bp from pter
Size:
11,244 bases
Orientation:
Plus strand

Genomic View for FCGR1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR1A Gene

Proteins for FCGR1A Gene

  • Protein details for FCGR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12314-FCGR1_HUMAN
    Recommended name:
    High affinity immunoglobulin gamma Fc receptor I
    Protein Accession:
    P12314
    Secondary Accessions:
    • P12315
    • Q5QNW7
    • Q92495
    • Q92663

    Protein attributes for FCGR1A Gene

    Size:
    374 amino acids
    Molecular mass:
    42632 Da
    Quaternary structure:
    • Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.

    Three dimensional structures from OCA and Proteopedia for FCGR1A Gene

    Alternative splice isoforms for FCGR1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR1A Gene

Proteomics data for FCGR1A Gene at MOPED

Post-translational modifications for FCGR1A Gene

  • Phosphorylated on serine residues.
  • Glycosylation at Asn 59, Asn 78, Asn 152, Asn 159, Asn 163, Asn 195, and Asn 240
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FCGR1A (Fc gamma RI/CD64)

No data available for DME Specific Peptides for FCGR1A Gene

Domains & Families for FCGR1A Gene

Gene Families for FCGR1A Gene

Protein Domains for FCGR1A Gene

Suggested Antigen Peptide Sequences for FCGR1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12314

UniProtKB/Swiss-Prot:

FCGR1_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
genes like me logo Genes that share domains with FCGR1A: view

Function for FCGR1A Gene

Molecular function for FCGR1A Gene

GENATLAS Biochemistry:
immunoglobulin G,high affinity Fc receptor 1A,expressed by macrophages,monocytes,neutrophils
UniProtKB/Swiss-Prot Function:
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Gene Ontology (GO) - Molecular Function for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 10879688
GO:0005515 protein binding IPI 18322202
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR1A: view
genes like me logo Genes that share phenotypes with FCGR1A: view

Animal Models for FCGR1A Gene

MGI Knock Outs for FCGR1A:

Animal Model Products

CRISPR Products

miRNA for FCGR1A Gene

miRTarBase miRNAs that target FCGR1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FCGR1A Gene

Localization for FCGR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR1A Gene

Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G.

Gene Ontology (GO) - Cellular Components for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030669 clathrin-coated endocytic vesicle membrane TAS --
GO:0031901 early endosome membrane TAS --
genes like me logo Genes that share ontologies with FCGR1A: view

No data available for Subcellular locations from COMPARTMENTS for FCGR1A Gene

Pathways & Interactions for FCGR1A Gene

genes like me logo Genes that share pathways with FCGR1A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006911 phagocytosis, engulfment TAS 10879688
GO:0006955 immune response TAS 10879688
GO:0007165 signal transduction TAS 10879688
genes like me logo Genes that share ontologies with FCGR1A: view

No data available for SIGNOR curated interactions for FCGR1A Gene

Drugs & Compounds for FCGR1A Gene

(44) Drugs for FCGR1A Gene - From: NovoSeek, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma Target 94,126
Abciximab Approved Pharma Target 63
Adalimumab Approved Pharma Target 411
Alefacept Approved, Withdrawn Pharma Target 40
alemtuzumab Approved, Investigational Pharma Target Therapeutic Antibodies 293

(23) Additional Compounds for FCGR1A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Actinomycin D
ALGINATE
Cycloheximide
Cytochalasin D
digitonin
genes like me logo Genes that share compounds with FCGR1A: view

Transcripts for FCGR1A Gene

Unigene Clusters for FCGR1A Gene

Fc fragment of IgG, high affinity Ia, receptor (CD64):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR1A Gene

No ASD Table

Relevant External Links for FCGR1A Gene

GeneLoc Exon Structure for
FCGR1A
ECgene alternative splicing isoforms for
FCGR1A

Expression for FCGR1A Gene

mRNA expression in normal human tissues for FCGR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR1A Gene

This gene is overexpressed in Whole Blood (x25.7).

Protein differential expression in normal tissues from HIPED for FCGR1A Gene

This gene is overexpressed in Placenta (47.1), Peripheral blood mononuclear cells (13.2), and Spleen (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR1A Gene



SOURCE GeneReport for Unigene cluster for FCGR1A Gene Hs.77424

mRNA Expression by UniProt/SwissProt for FCGR1A Gene

P12314-FCGR1_HUMAN
Tissue specificity: Monocyte/macrophage specific
genes like me logo Genes that share expression patterns with FCGR1A: view

Protein tissue co-expression partners for FCGR1A Gene

Primer Products

In Situ Assay Products

Orthologs for FCGR1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCGR1A 35
  • 80.99 (n)
  • 67.54 (a)
FCGR1A 36
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FCGR1A 35
  • 82.77 (n)
  • 73.46 (a)
FCGR1A 36
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fcgr1 35
  • 78.17 (n)
  • 70.76 (a)
Fcgr1 16
Fcgr1 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FCGR1A 35
  • 98.93 (n)
  • 97.86 (a)
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fcgr1a 35
  • 77.38 (n)
  • 66.67 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
Species with no ortholog for FCGR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR1A Gene

ENSEMBL:
Gene Tree for FCGR1A (if available)
TreeFam:
Gene Tree for FCGR1A (if available)

Paralogs for FCGR1A Gene

(15) SIMAP similar genes for FCGR1A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FCGR1A Gene

genes like me logo Genes that share paralogs with FCGR1A: view

Variants for FCGR1A Gene

Sequence variations from dbSNP and Humsavar for FCGR1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_019522 -

Structural Variations from Database of Genomic Variants (DGV) for FCGR1A Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
dgv126e1 CNV Complex 17122850
nsv470736 CNV Gain 18288195
nsv872384 CNV Gain 21882294
esv21909 CNV Gain 19812545
dgv73n67 CNV Gain 20364138
nsv824564 CNV Gain 20364138
nsv831503 CNV Gain 17160897
nsv469694 CNV Loss 16826518
nsv831525 CNV Gain 17160897
nsv872414 CNV Gain 21882294
essv23032 CNV CNV 17122850

Variation tolerance for FCGR1A Gene

Residual Variation Intolerance Score: 66.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGR1A Gene

HapMap Linkage Disequilibrium report
FCGR1A
Human Gene Mutation Database (HGMD)
FCGR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR1A Gene

Disorders for FCGR1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for FCGR1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervical adenitis
  • cervical lymphadenitis
tetrasomy 21
  • isochromosome 21
pharyngitis
  • chronic pharyngitis
interleukin-7 receptor alpha deficiency
  • il-7r
tuberculosis
  • tuberculous abscess
- elite association

Relevant External Links for FCGR1A

Genetic Association Database (GAD)
FCGR1A
Human Genome Epidemiology (HuGE) Navigator
FCGR1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR1A
genes like me logo Genes that share disorders with FCGR1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR1A Gene

Publications for FCGR1A Gene

  1. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco D.L. … Theil K.S. (Cytogenet. Cell Genet. 1998) 2 23 67
  2. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco D.L. … Anderson C.L. (Cytogenet. Cell Genet. 1996) 2 23 67
  3. Dalotuzumab, a recombinant humanized mAb targeted against IGFR1 for the treatment of cancer. (PMID: 20521225) Scartozzi M. … Cascinu S. (Curr. Opin. Mol. Ther. 2010) 23 67
  4. High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients. (PMID: 19153117) Ludovini V. … CrinA^ L. (Ann. Oncol. 2009) 23 67
  5. C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo. (PMID: 18621373) Devaraj S. … Jialal I. (Atherosclerosis 2009) 23 67

Products for FCGR1A Gene

Sources for FCGR1A Gene

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