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Aliases for FCGR1A Gene

Aliases for FCGR1A Gene

  • Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64) 2 3
  • IGFR1 3 4 6
  • Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64) 2 3
  • IgG Fc Receptor I 3 4
  • Fc-Gamma RIA 3 4
  • Fc-Gamma RI 3 4
  • FcgammaRIa 3 4
  • FCRI 3 4
  • CD64 3 6
  • High Affinity Immunoglobulin Gamma Fc Receptor I 3
  • Fc-Gamma Receptor I A1 3
  • Fc Gamma Receptor 3
  • CD64 Antigen 4
  • CD64A 3
  • FCGR1 4
  • FCG1 4

External Ids for FCGR1A Gene

Summaries for FCGR1A Gene

Entrez Gene Summary for FCGR1A Gene

  • This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCGR1A Gene

FCGR1A (Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64)) is a Protein Coding gene. Diseases associated with FCGR1A include pharyngitis and peritonitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and GPCR Pathway. GO annotations related to this gene include receptor signaling protein activity and IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR1A Gene

  • High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Gene Wiki entry for FCGR1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR1A Gene

Genomics for FCGR1A Gene

Genomic Location for FCGR1A Gene

149,782,671 bp from pter
149,792,518 bp from pter
9,848 bases
Plus strand

Genomic View for FCGR1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR1A Gene

Regulatory Elements for FCGR1A Gene

Proteins for FCGR1A Gene

  • Protein details for FCGR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    High affinity immunoglobulin gamma Fc receptor I
    Protein Accession:
    Secondary Accessions:
    • P12315
    • Q5QNW7
    • Q92495
    • Q92663

    Protein attributes for FCGR1A Gene

    374 amino acids
    Molecular mass:
    42632 Da
    Quaternary structure:
    • Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.

    Three dimensional structures from OCA and Proteopedia for FCGR1A Gene

    Alternative splice isoforms for FCGR1A Gene


neXtProt entry for FCGR1A Gene

Proteomics data for FCGR1A Gene at MOPED

Post-translational modifications for FCGR1A Gene

  • Phosphorylated on serine residues.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn59, Asn78, Asn152, Asn159, Asn163, Asn195, and Asn240

Other Protein References for FCGR1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FCGR1A Gene

Domains for FCGR1A Gene

Gene Families for FCGR1A Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCGR1A Gene

Suggested Antigen Peptide Sequences for FCGR1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • P12314
  • Belongs to the immunoglobulin superfamily. FCGR1 family.:
    • P12314
genes like me logo Genes that share domains with FCGR1A: view

Function for FCGR1A Gene

Molecular function for FCGR1A Gene

GENATLAS Biochemistry: immunoglobulin G,high affinity Fc receptor 1A,expressed by macrophages,monocytes,neutrophils
UniProtKB/Swiss-Prot Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Gene Ontology (GO) - Molecular Function for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 10879688
GO:0005515 protein binding IPI 18322202
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR1A: view

Phenotypes for FCGR1A Gene

genes like me logo Genes that share phenotypes with FCGR1A: view

Animal Models for FCGR1A Gene

MGI Knock Outs for FCGR1A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FCGR1A Gene

Localization for FCGR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR1A Gene

Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G.

Subcellular locations from

Jensen Localization Image for FCGR1A Gene COMPARTMENTS Subcellular localization image for FCGR1A gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030669 clathrin-coated endocytic vesicle membrane TAS --
GO:0031901 early endosome membrane TAS --
genes like me logo Genes that share ontologies with FCGR1A: view

Pathways for FCGR1A Gene

genes like me logo Genes that share pathways with FCGR1A: view

Gene Ontology (GO) - Biological Process for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006911 phagocytosis, engulfment TAS 10879688
GO:0006955 immune response TAS 10879688
GO:0007165 signal transduction TAS 10879688
genes like me logo Genes that share ontologies with FCGR1A: view

Compounds for FCGR1A Gene

(21) Drugbank Compounds for FCGR1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 7E3
143653-53-6 target
331731-18-1 target
222535-22-0 target
216503-57-0 target
  • chimeric mouse-human antiCD25
152923-56-3 target

(38) Novoseek inferred chemical compound relationships for FCGR1A Gene

Compound -log(P) Hits PubMed IDs
tyrosine 46.6 42
herbimycin a 37.4 1
fmlp 34.3 2
latex 29.3 1
genistein 29.2 2
genes like me logo Genes that share compounds with FCGR1A: view

Transcripts for FCGR1A Gene

Unigene Clusters for FCGR1A Gene

Fc fragment of IgG, high affinity Ia, receptor (CD64):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR1A Gene

No ASD Table

Relevant External Links for FCGR1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCGR1A Gene

mRNA expression in normal human tissues for FCGR1A Gene

mRNA differential expression in normal tissues according to GTEx for FCGR1A Gene

This gene is overexpressed in Whole Blood (25.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCGR1A Gene

SOURCE GeneReport for Unigene cluster for FCGR1A Gene Hs.77424

mRNA Expression by UniProt/SwissProt for FCGR1A Gene

Tissue specificity: Monocyte/macrophage specific
genes like me logo Genes that share expressions with FCGR1A: view

Orthologs for FCGR1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
  • 98.93 (n)
  • 97.86 (a)
(Bos Taurus)
Mammalia FCGR1A 35
  • 80.99 (n)
  • 67.54 (a)
  • 66 (a)
(Canis familiaris)
Mammalia FCGR1A 35
  • 82.77 (n)
  • 73.46 (a)
  • 64 (a)
(Mus musculus)
Mammalia Fcgr1 35
  • 78.17 (n)
  • 70.76 (a)
Fcgr1 16
Fcgr1 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
-- 36
  • 38 (a)
-- 36
  • 39 (a)
-- 36
  • 44 (a)
-- 36
  • 42 (a)
(Rattus norvegicus)
Mammalia Fcgr1a 35
  • 77.38 (n)
  • 66.67 (a)
Species with no ortholog for FCGR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR1A Gene

Gene Tree for FCGR1A (if available)
Gene Tree for FCGR1A (if available)

Paralogs for FCGR1A Gene

Selected SIMAP similar genes for FCGR1A Gene using alignment to 2 proteins: Pseudogenes for FCGR1A Gene

genes like me logo Genes that share paralogs with FCGR1A: view

Variants for FCGR1A Gene

Sequence variations from dbSNP and Humsavar for FCGR1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_019522 -

Structural Variations from Database of Genomic Variants (DGV) for FCGR1A Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
dgv126e1 CNV Complex 17122850
nsv470736 CNV Gain 18288195
nsv872384 CNV Gain 21882294
esv21909 CNV Gain 19812545
dgv73n67 CNV Gain 20364138
nsv824564 CNV Gain 20364138
nsv831503 CNV Gain 17160897
nsv469694 CNV Loss 16826518
nsv831525 CNV Gain 17160897
nsv872414 CNV Gain 21882294
essv23032 CNV CNV 17122850

Relevant External Links for FCGR1A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR1A Gene

Disorders for FCGR1A Gene

(2) MalaCards Diseases for FCGR1A Gene

Search for FCGR1A Gene in MalaCards »

(30) Novoseek inferred disease relationships for FCGR1A Gene

Disease -log(P) Hits PubMed IDs
antibody-dependent enhancement 63.1 1
purpura thrombocytopenic 34.7 2
bacterial infections 31.4 15
myeloma 15.2 1
necrosis 14.1 4

Relevant External Links for FCGR1A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FCGR1A: view

No data available for UniProtKB/Swiss-Prot for FCGR1A Gene

Publications for FCGR1A Gene

  1. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PMID: 1379234) Ernst L.K. … Anderson C.L. (J. Biol. Chem. 1992) 3 4 23
  2. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. (PMID: 8064233) Wang A.V. … Geha R.S. (J. Exp. Med. 1994) 3 4 23
  3. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco D.L. … Anderson C.L. (Cytogenet. Cell Genet. 1996) 2 3 23
  4. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco D.L. … Theil K.S. (Cytogenet. Cell Genet. 1998) 2 3 23
  5. Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI). (PMID: 9820532) Kyono W.T. … Durden D.L. (J. Immunol. 1998) 3 23

Products for FCGR1A Gene

Sources for FCGR1A Gene

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