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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCGR1A Gene

protein-coding   GIFtS: 65
GCID: GC01P149754

Fc fragment of IgG, high affinity Ia, receptor (CD64)

(Previous names: Fc fragment of IgG, high affinity Ia, receptor for (CD64)...)
 Explore 49 diseases affiliated with
FCGR1A via
MalaCards
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 Human Malady Compendium 
Biological research products
for FCGR1A    

Aliases
for FCGR1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64)1 2     Fc Gamma Receptor2
CD641 2 5     Fc-Gamma Receptor I A12
IGFR12 3 5     FcgammaRIa3
CD64A1 2     High Affinity Immunoglobulin Gamma Fc Receptor I2
Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64)1 2     FCG13
Fc-Gamma RIA2 3     FCGR13
Fc-Gamma RI2 3     FcRI3
IgG Fc Receptor I2 3     FcgammaRIa3
FCRI2     CD64 Antigen3

External Ids:    HGNC: 36131   Entrez Gene: 22092   Ensembl: ENSG000001503377   OMIM: 1467605   UniProtKB: P123143   

Export aliases for FCGR1A gene to outside databases

Previous GC identifers: GC01P147395 GC01P141381 GC01P146529 GC01P146970 GC01P146567 GC01P148020


Summaries
for FCGR1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FCGR1A:
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity
Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314
Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive
immune responses

Gene Wiki entry for FCGR1A


Genomic Views
for FCGR1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCGR1A gene promoter:
         HOXA9B   HOXA9   STAT1   p53   STAT1beta   HNF-3beta   Meis-1b   STAT1alpha   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCGR1A promoter sequence
   Search SABiosciences Chromatin IP Primers for FCGR1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2-q21.3   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2-q21.3

FCGR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149754:  view genomic region     (about GC identifiers)

Start:
 149,754,227 bp from pter      End:
 149,764,074 bp from pter
Size:
 9,848 bases      Orientation:
 plus strand

Proteins
for FCGR1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314 (See protein sequence)
Recommended Name: High affinity immunoglobulin gamma Fc receptor I precursor  
Size: 374 amino acids; 42632 Da
Subunit: Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation.
Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through
interaction with FCER1G
1 PDB 3D structure from and Proteopedia for FCGR1A:
3RJD (3D)    
Secondary accessions: P12315 Q5QNW7 Q92495 Q92663
Alternative splicing: 2 isoforms:  P12314-1   P12314-2   

Explore the universe of human proteins at neXtProt for FCGR1A: NX_P12314

Post-translational modifications:

  • Phosphorylated on serine residues (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12314

    • FCGR1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000557.1  
    ENSEMBL proteins: 
     ENSP00000394279   ENSP00000358165  
    Reactome Protein details: P12314
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for FCGR1A (Fc gamma RI/CD64)
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    Novus Biologicals FCGR1A Proteins
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    Sino Biological Recombinant Protein for FCGR1A
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0030669clathrin-coated endocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--


    FCGR1A for ontologies           About GeneDecksing



    FCGR1A Antibody Products: 
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    ThermoFisher Antibody for FCGR1A

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for FCGR1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FCGR1A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P12314

    ProtoNet protein and cluster: P12314

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314
    Similarity: Belongs to the immunoglobulin superfamily. FCGR1 family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for FCGR1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314
    Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive
    immune responses

         Genatlas biochemistry entry for FCGR1A:
    immunoglobulin G,high affinity Fc receptor 1A,expressed by macrophages,monocytes,neutrophils

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate FCGR1A:
    hsa-miR-642a hsa-miR-4328 hsa-miR-1303 hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmid: FCGR1A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for FCGR1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1A

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005057receptor signaling protein activity TAS10879688
    GO:0005515protein binding IPI18322202
    GO:0019770IgG receptor activity IEA--
    GO:0019864IgG binding IEA--


    FCGR1A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FCGR1A:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for FCGR1A: Fcgr1tm1Hoga Fcgr1tm1Jgjw Fcgr1tm1Sjv
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fcgr1):
     cellular  hematopoietic system  immune system  normal  skeleton 

    FCGR1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FCGR1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    2Regulation of actin dynamics for phagocytic cup formation
    		Regulation of actin dynamics for phagocytic cup formation1.00
    		Fcgamma receptor (FCGR) dependent phagocytosis0.80
    		Role of myosins in phagosome formation0.80
    3Cleavage of Alpha-1-Microglobulin
    		Sequestering and phosphorylation Fc gamma receptors in the lipid rafts0.66
    		Role of phospholipids in phagocytosis0.53
    		FCGR activation0.65
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    5Interferon gamma signaling
    		Interferon gamma signaling1.00
    		Expression of IFNG-stimulated genes0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FCGR1A
        Fc-GammaR Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages
    NFAT in Immune Response
    Phagocytosis of Microbes

    5/16        Reactome Pathways for FCGR1A (see all 16)
        Role of myosins in phagosome formation
    FCGR activation
    Interferon Signaling
    Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
    Class I MHC mediated antigen processing & presentation


    5/8         Kegg Pathways  (Kegg details for FCGR1A) (see all 8):
        Phagosome
    Osteoclast differentiation
    Hematopoietic cell lineage
    Fc gamma R-mediated phagocytosis
    Leishmaniasis


    FCGR1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCGR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for FCGR1A (P123142, 3 ENSP000003581654) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130942, 3, ENSP000000467944MINT-17488 I2D: score=1 STRING: ENSP00000046794
    SHC1P293532, 3, ENSP000004013034MINT-15946 I2D: score=1 STRING: ENSP00000401303
    CBLP226812, 3, ENSP000002640334MINT-17062 I2D: score=1 STRING: ENSP00000264033
    CRKLP461093, ENSP000003463004I2D: score=3 STRING: ENSP00000346300
    HCKP086313, ENSP000003650124I2D: score=3 STRING: ENSP00000365012
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001788antibody-dependent cellular cytotoxicity IEA--
    GO:0001798positive regulation of type IIa hypersensitivity IEA--
    GO:0001805positive regulation of type III hypersensitivity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--


    FCGR1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for FCGR1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCGR1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCGR1A

    10/21 DrugBank Compounds for FCGR1A (see all 21)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetantagonist17351760 20441428 17911465
    TrastuzumabAnti HER2 (see all 2)180288-69-1target--9435876 17016423 17139284
    Abciximab7E3 antibody (see all 4)143653-53-6target--17016423 17139284
    Adalimumab-- 331731-18-1target--17016423 17139284
    Alefacept-- 222535-22-0target--17139284 17016423
    Alemtuzumab-- 216503-57-0target--17016423 17139284
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3target--17016423 17139284
    BevacizumabantiVEGF (see all 3)216974-75-3target--17139284 17016423
    Efalizumabanti alphaL integrin (see all 4)214745-43-4target--17139284 17016423
    EtanerceptCD120b (see all 7)185243-69-0target--17139284 17016423

    10/38 Novoseek chemical compound relationships for FCGR1A gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 46.6 53 8993005 (4), 7859733 (4), 7705403 (3), 7995951 (3) (see all 25)
    herbimycin a 37.4 1 10979209 (1)
    fmlp 34.3 4 1370419 (1), 1431552 (1)
    latex 29.3 1 9973503 (1)
    genistein 29.2 2 7927687 (1), 10979209 (1)
    exotoxin-a 27.3 1 9657258 (1)
    superoxide 27.2 5 9266281 (2), 7594506 (1), 18621373 (1)
    cycloheximide 27.1 5 1834666 (1), 8956369 (1), 2141616 (1), 7565811 (1)
    zymosan 26.7 1 7957310 (1)
    digitonin 20.1 1 8415618 (1)

    Search CenterWatch for drugs/clinical trials and news about FCGR1A / FCGR1 

    Transcripts
    for FCGR1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FCGR1A gene: 
    NM_000566.3  

    Unigene Cluster for FCGR1A:

    Fc fragment of IgG, high affinity Ia, receptor (CD64)
    Hs.77424  [show with all ESTs]
    Unigene Representative Sequence: NM_000566
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444948 ENST00000369168(uc009wlh.1 uc001esp.4) ENST00000489479
    ENST00000489704

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK291451.1 AK291502.1 BC032634.1 BC152383.1 DQ786309.1 L03418.1 X14355.1 X14356.1 

    11 DOTS entries:

    DT.114591  DT.121372964  DT.95375845  DT.100754132  DT.92422747  DT.121372981  DT.100754131  DT.121330997 
    DT.121372818  DT.121372988  DT.99989558 

    24/66 AceView cDNA sequences (see all 66):

    BX952705 AI886388 F08275 BM699171 BI823671 AL543551 L03418 BQ002319 
    AW014990 CR622515 CR608315 CD677475 AI825678 CR591922 NM_000566 BC032634 
    AA453359 AW592667 BV204029 BM669833 AA923811 BG621147 AW134502 AA873178 

    GeneLoc Exon Structure


    Expression
    for FCGR1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCGR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTATGTAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FCGR1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCGR1A

    SOURCE GeneReport for Unigene cluster: Hs.77424

    UniProtKB/Swiss-Prot: FCGR1_HUMAN, P12314
    Tissue specificity: Monocyte/macrophage specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including FCGR1A: 
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              Lymphoma in human mouse rat
              Antifungal Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCGR1A

    Orthologs
    for FCGR1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FCGR1A gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 --
    		 31(a)
    		 1 → many
    		 25(1707231-1709870)


    ENSEMBL Gene Tree for FCGR1A (if available)
    TreeFam Gene Tree for FCGR1A (if available) 

    Paralogs
    for FCGR1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCGR1A gene
    FCGR2B2  FCGR1B2  FCGR3B2  FCRL22  FCRLB2  FCRL12  FCRL42  FCRL52  
    FCRLA2  FCGR2A2  FCGR3A2  FCRL32  FCER1A2  FCRL62  
    15 SIMAP similar genes for FCGR1A using alignment to 2 protein entries:     FCGR1_HUMAN (see all proteins):
    FCER1A    FCRLA    FCGR2A    FCGR2C    FCGR3A    FCGR3B
    Fc-gamma receptor IIIB    FCGR2B    FCRL2    FCRL6    FCRL5    FCGR1C
    FCGR1B    FCRL3    FCRLB

    FCGR1A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FCGR1A
    PGOHUM00000251071


    Genomic Variants
    for FCGR1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/132 NCBI SNPs in FCGR1A are shown (see all 132)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs562261871,2
    		C,F--149752366(+) GAATCG/ACAAGG 1 -- us2k12Minor allele frequency- A:0.37NA 8
    rs802424221,2
    		F--149752587(+) CTGGCA/TTGTAA 1 -- us2k11Minor allele frequency- T:0.33NA 6
    rs1822347631,2
    		--149753099(+) CAGGTA/GAGGCA 1 -- us2k10--------
    rs6080741,2
    		C,A,H--149753106(+) GGCAGC/GTCTGC 1 -- us2k12Minor allele frequency- G:0.00NA 4
    rs6638511,2
    		C,A,H,--149753145(+) GTTTCG/ACACTG 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs21039141,2
    		C,A,H--149753149(+) CGCACG/TGTGGC 1 -- us2k10--------
    rs6089601,2
    		F,H--149753325(+) AGAGAC/TATACC 1 -- us2k16Minor allele frequency- T:0.01NS EA NA 416
    rs29832691,2
    		C,F,A,H,--149753326(+) GAGACA/GTACCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs30056011,2
    		C,A,H--149753395(+) ACCAAC/TTTACA 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs30056021,2
    		C,A,H--149753396(+) CCAACC/TTACAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCGR1A (149754227 - 149764074 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for FCGR1A
         10 CNVs: 64904 3313 2326 48130 48129 48128 64903 4255 8329 2052
    Human Gene Mutation Database (HGMD): FCGR1A

    Locus Specific Mutation Databases (LSDB): FCGR1A

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCGR1A
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGR1A

    Disorders / Diseases
    for FCGR1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FCGR1A for disorders           About GeneDecksing

    OMIM gene information: 146760    OMIM disorders: --

    20/49 diseases for FCGR1A (see all 49):    About MalaCards
    igg receptor i, phagocytic, familial deficiency of    hypersensitivity reaction type ii disease    arthus reaction    familial mediterranean fever
    severe congenital neutropenia    inflammatory bowel disease    alopecia areata    lupus erythematosus
    systemic lupus erythematosus    allergic rhinitis    pleomorphic adenoma    atopic dermatitis
    rheumatoid arthritis    acute myeloid leukemia    alopecia    neutropenia
    myeloid leukemia    purpura    dermatitis    rhinitis

    10/30 Novoseek disease relationships for FCGR1A gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antibody-dependent enhancement 63.1 1 1976824 (1)
    purpura thrombocytopenic 34.7 2 9435876 (1), 8616043 (1)
    bacterial infections 31.4 16 17577814 (6), 16028647 (2), 16308225 (2), 12558136 (2) (see all 7)
    myeloma 15.2 1 16818279 (1)
    necrosis 14.1 4 11095999 (1), 11211151 (1), 1837029 (1), 2137489 (1)
    tumors 12.1 27 19153117 (3), 12516969 (2), 10820252 (2), 20078550 (2) (see all 19)
    lupus erythematosus systemic 11 3 7481565 (1), 7973454 (1), 14728877 (1)
    rheumatoid arthritis 10.5 2 9227327 (2)
    acute leukemia 7.84 4 16403274 (1), 14679004 (1)
    shock septic 7.15 4 11797018 (4)

    Genetic Association Database (GAD): FCGR1A
    Human Genome Epidemiology (HuGE) Navigator: FCGR1A (5 documents)

    Export disorders for FCGR1A gene to outside databases

    Publications
    for FCGR1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCGR1A gene, integrated from 9 sources (see all 355):
    (articles sorted by number of sources associating them with FCGR1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. (PubMed id 8064233)1, 2, 9 Wang A.V....Geha R.S. (1994)
    2. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PubMed id 8697799)1, 3, 9 Maresco D.L.... Anderson C.L. (1996)
    3. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PubMed id 1379234)1, 2, 9 Ernst L.K.... Anderson C.L. (1992)
    4. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the ev olution of human chromosome 1. (PubMed id 9763663)1, 3, 9 Maresco D.L....Theil K.S. (1998)
    5. Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing. (PubMed id 18322202)1, 2 Beekman J.M....Leusen J.H.W. (2008)
    6. Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail. (PubMed id 18023480)1, 2 Beekman J.M.... Leusen J.H.W. (2008)
    7. Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity. (PubMed id 15229321)1, 2 Beekman J.M.... Leusen J.H.W. (2004)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    9. Genetic variants of FcepsilonRIbeta and Il-4 and atopy in a Polish population. (PubMed id 15087090)1, 4 Korzycka-Zaborowska B....Gorski P. (2004)
    10. Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis. (PubMed id 12756162)1, 2 Kim M.-K.... Schreiber A.D. (2003)

    External Searches for FCGR1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing FCGR1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2209 HGNC: 3613 AceView: FCGR1A Ensembl:ENSG00000150337 euGenes: HUgn2209
    ECgene: FCGR1A Kegg: 2209 H-InvDB: FCGR1A

    Other Databases showing FCGR1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FCGR1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCGR1A Pharmacogenomics, SNPs, Pathways
    FCGR1Abasehttp://bioinf.uta.fi/FCGR1Abase/

    Intellectual Property
    for FCGR1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FCGR1A gene:
    Search GeneIP for patents involving FCGR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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