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Aliases for FCGBP Gene

Aliases for FCGBP Gene

  • Fc Fragment Of IgG Binding Protein 2 3 5
  • Fcgamma-Binding Protein Antigen 3 4
  • IgG Fc Binding Protein 2 3
  • Human Fc Gamma BP 2 3
  • FcgammaBP 3 4
  • IgGFc-Binding Protein 3

External Ids for FCGBP Gene

Previous GeneCards Identifiers for FCGBP Gene

  • GC19M041007
  • GC19M040745
  • GC19M045030
  • GC19M045045
  • GC19M040353

Summaries for FCGBP Gene

GeneCards Summary for FCGBP Gene

FCGBP (Fc Fragment Of IgG Binding Protein) is a Protein Coding gene. An important paralog of this gene is ZAN.

UniProtKB/Swiss-Prot for FCGBP Gene

  • May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.

Gene Wiki entry for FCGBP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGBP Gene

Genomics for FCGBP Gene

Regulatory Elements for FCGBP Gene

Enhancers for FCGBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F039968 0.7 FANTOM5 48.1 -33.6 -33551 0.3 ZBTB33 PRDM1 FCGBP ZNF546 PIR61583 GC19P039957
GH19F039959 0.8 FANTOM5 Ensembl 45.3 -25.2 -25175 1.6 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SNRPA FCGBP ENSG00000269843 FBL ENSG00000269069 ENSG00000205041 ZNF780A ITPKC RPS16 COQ8B
GH19F039940 1.3 FANTOM5 Ensembl ENCODE 35.8 -8.9 -8947 6.9 PKNOX1 MLX WRNIP1 SIN3A DMAP1 SLC30A9 ZNF121 GLIS2 CBX5 SP3 FCGBP ZNF780A PSMC4 ENSG00000269843 SNRPA FBL EID2B CNTD2 TTC9B ZNF546
GH19F039950 1.3 FANTOM5 Ensembl ENCODE 29.1 -18.2 -18213 4.3 PKNOX1 BMI1 ZNF384 EBF1 RELA ZNF121 HIC1 ZNF664 CBX5 NFYB FCGBP FBL ENSG00000269069 ZNF780A ZNF546 GC19P039957 PRR13P5
GH19F039969 1.1 ENCODE 26.6 -36.2 -36186 3.6 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FCGBP ZNF780A ENSG00000269843 RPS16 FBL SNRPA ENSG00000268366 CYP2F2P RN7SL566P ITPKC
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FCGBP on UCSC Golden Path with GeneCards custom track

Genomic Location for FCGBP Gene

39,863,323 bp from pter
39,934,626 bp from pter
71,304 bases
Minus strand

Genomic View for FCGBP Gene

Genes around FCGBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGBP Gene

Proteins for FCGBP Gene

  • Protein details for FCGBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IgGFc-binding protein
    Protein Accession:
    Secondary Accessions:
    • O95784

    Protein attributes for FCGBP Gene

    5405 amino acids
    Molecular mass:
    572017 Da
    Quaternary structure:
    • Interacts with the Fc portion of IgG and with MUC2.

neXtProt entry for FCGBP Gene

Post-translational modifications for FCGBP Gene

  • Glycosylation at Asn 75, Asn 91, Asn 1317, Asn 1743, Asn 2138, Asn 2518, Asn 3719, Asn 4145, and Asn 4540
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCGBP Gene

Domains & Families for FCGBP Gene

Suggested Antigen Peptide Sequences for FCGBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal IgGFc-binding region is primate-specific.
  • The N-terminal IgGFc-binding region is primate-specific.
  • Contains 12 TIL (trypsin inhibitory-like) domains.
  • Contains 13 VWFD domains.
genes like me logo Genes that share domains with FCGBP: view

No data available for Gene Families for FCGBP Gene

Function for FCGBP Gene

Molecular function for FCGBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.

Gene Ontology (GO) - Molecular Function for FCGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19432394
genes like me logo Genes that share ontologies with FCGBP: view
genes like me logo Genes that share phenotypes with FCGBP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FCGBP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGBP Gene

Localization for FCGBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGBP Gene


Subcellular locations from

Jensen Localization Image for FCGBP Gene COMPARTMENTS Subcellular localization image for FCGBP gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FCGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FCGBP: view

Pathways & Interactions for FCGBP Gene

SuperPathways for FCGBP Gene

No Data Available

Interacting Proteins for FCGBP Gene

Selected Interacting proteins: Q9Y6R7-FCGBP_HUMAN for FCGBP Gene via IID

Gene Ontology (GO) - Biological Process for FCGBP Gene


No data available for Pathways by source and SIGNOR curated interactions for FCGBP Gene

Transcripts for FCGBP Gene

mRNA/cDNA for FCGBP Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(263) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCGBP Gene

Fc fragment of IgG binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGBP Gene

No ASD Table

Relevant External Links for FCGBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCGBP Gene

mRNA expression in normal human tissues for FCGBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGBP Gene

This gene is overexpressed in Colon - Transverse (x22.4), Thyroid (x6.9), and Small Intestine - Terminal Ileum (x6.6).

Protein differential expression in normal tissues from HIPED for FCGBP Gene

This gene is overexpressed in Vitreous humor (14.6), Rectum (13.2), Fetal gut (11.8), Pancreatic juice (10.1), Colon (8.8), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCGBP Gene

NURSA nuclear receptor signaling pathways regulating expression of FCGBP Gene:


SOURCE GeneReport for Unigene cluster for FCGBP Gene:


mRNA Expression by UniProt/SwissProt for FCGBP Gene:

Tissue specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).
genes like me logo Genes that share expression patterns with FCGBP: view

Primer Products

No data available for Protein tissue co-expression partners for FCGBP Gene

Orthologs for FCGBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCGBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCGBP 34
  • 98.29 (n)
(Bos Taurus)
Mammalia FCGBP 34
  • 77.48 (n)
(Canis familiaris)
Mammalia FCGBP 34
  • 77.47 (n)
(Mus musculus)
Mammalia Fcgbp 34 16
  • 73.96 (n)
(Rattus norvegicus)
Mammalia Fcgbp 34
  • 73.49 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fcgbp 34
  • 49.46 (n)
Str.15640 34
(Danio rerio)
Actinopterygii si:dkey-65b12.6 34
  • 46.6 (n)
Species where no ortholog for FCGBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FCGBP Gene

Gene Tree for FCGBP (if available)
Gene Tree for FCGBP (if available)

Paralogs for FCGBP Gene

Paralogs for FCGBP Gene

(2) SIMAP similar genes for FCGBP Gene using alignment to 2 proteins: Pseudogenes for FCGBP Gene

genes like me logo Genes that share paralogs with FCGBP: view

Variants for FCGBP Gene

Sequence variations from dbSNP and Humsavar for FCGBP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401967 -- 39,908,586(+) tccag(C/T)gatcc intron-variant
rs10401972 -- 39,917,174(+) CACAG(A/C)ACTGG intron-variant
rs10403036 -- 39,879,672(+) GTGAC(A/G)GTGAA reference, synonymous-codon
rs10403635 -- 39,879,435(+) ATTCT(C/T)TTTGT intron-variant
rs10404619 -- 39,912,344(+) TTATA(A/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGBP Gene

Variant ID Type Subtype PubMed ID
dgv6440n54 CNV loss 21841781
dgv6441n54 CNV loss 21841781
esv1006063 CNV gain 20482838
esv1010625 CNV loss 20482838
esv2660568 CNV deletion 23128226
esv2718556 CNV deletion 23290073
esv2758760 CNV gain 17122850
esv2763204 CNV loss 21179565
nsv1060617 CNV gain 25217958
nsv1066339 CNV loss 25217958
nsv1072353 CNV deletion 25765185
nsv1076470 CNV duplication 25765185
nsv1115548 CNV duplication 24896259
nsv1118618 CNV duplication 24896259
nsv1118830 CNV deletion 24896259
nsv1126523 CNV deletion 24896259
nsv1150919 CNV duplication 26484159
nsv1160617 CNV deletion 26073780
nsv176 CNV insertion 15895083
nsv177 CNV deletion 15895083
nsv2483 CNV deletion 18451855
nsv2484 CNV insertion 18451855
nsv436744 CNV insertion 17901297
nsv442460 CNV gain+loss 18776908
nsv482218 CNV gain 20164927
nsv509742 CNV insertion 20534489
nsv510766 CNV deletion 20534489
nsv579515 CNV loss 21841781
nsv579518 CNV loss 21841781
nsv579520 CNV loss 21841781
nsv579521 CNV loss 21841781
nsv579522 CNV loss 21841781
nsv579523 CNV loss 21841781
nsv579524 CNV loss 21841781
nsv953574 CNV deletion 24416366
nsv9725 CNV gain+loss 18304495

Variation tolerance for FCGBP Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 28.93; 99.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGBP Gene

Disorders for FCGBP Gene

Relevant External Links for FCGBP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FCGBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCGBP Gene

Publications for FCGBP Gene

  1. Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (PMID: 12208673) O'Donovan N. … Marti U. (J. Endocrinol. 2002) 3 4 22 64
  2. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. (PMID: 9182547) Harada N. … Morikawa M. (J. Biol. Chem. 1997) 2 3 4 64
  3. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (PMID: 19432394) Johansson M.E.V. … Hansson G.C. (J. Proteome Res. 2009) 3 4 64
  4. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PMID: 19956635) Holmes M.V. … Casas J.P. (PLoS ONE 2009) 3 46 64
  5. Downregulation of IgG Fc binding protein (Fc gammaBP) in prostate cancer. (PMID: 17938577) Gazi M.H. … Young C.Y. (Cancer Biol. Ther. 2008) 3 22 64

Products for FCGBP Gene

Sources for FCGBP Gene

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