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Aliases for FCGBP Gene

Aliases for FCGBP Gene

  • Fc Fragment Of IgG Binding Protein 2 3
  • Fcgamma-Binding Protein Antigen 3 4
  • IgG Fc Binding Protein 2 3
  • Human Fc Gamma BP 2 3
  • FcgammaBP 3 4
  • FC(GAMMA)BP 3

External Ids for FCGBP Gene

Previous GeneCards Identifiers for FCGBP Gene

  • GC19M041007
  • GC19M040745
  • GC19M045030
  • GC19M045045
  • GC19M040353

Summaries for FCGBP Gene

GeneCards Summary for FCGBP Gene

FCGBP (Fc Fragment Of IgG Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FCGBP Gene

  • May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.

Gene Wiki entry for FCGBP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGBP Gene

Genomics for FCGBP Gene

Regulatory Elements for FCGBP Gene

Genomic Location for FCGBP Gene

Chromosome:
19
Start:
39,863,323 bp from pter
End:
39,934,626 bp from pter
Size:
71,304 bases
Orientation:
Minus strand

Genomic View for FCGBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGBP Gene

Proteins for FCGBP Gene

  • Protein details for FCGBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6R7-FCGBP_HUMAN
    Recommended name:
    IgGFc-binding protein
    Protein Accession:
    Q9Y6R7
    Secondary Accessions:
    • O95784

    Protein attributes for FCGBP Gene

    Size:
    5405 amino acids
    Molecular mass:
    572017 Da
    Quaternary structure:
    • Interacts with the Fc portion of IgG and with MUC2.

neXtProt entry for FCGBP Gene

Proteomics data for FCGBP Gene at MOPED

Post-translational modifications for FCGBP Gene

  • Glycosylation at Asn 75, Asn 91, Asn 1317, Asn 1743, Asn 2138, Asn 2518, Asn 3719, Asn 4145, and Asn 4540
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FCGBP Gene

Domains & Families for FCGBP Gene

Suggested Antigen Peptide Sequences for FCGBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6R7

UniProtKB/Swiss-Prot:

FCGBP_HUMAN :
  • The N-terminal IgGFc-binding region is primate-specific
Domain:
  • The N-terminal IgGFc-binding region is primate-specific
  • Contains 12 TIL (trypsin inhibitory-like) domains.
  • Contains 13 VWFD domains.
genes like me logo Genes that share domains with FCGBP: view

No data available for Gene Families for FCGBP Gene

Function for FCGBP Gene

Molecular function for FCGBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.

Gene Ontology (GO) - Molecular Function for FCGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19432394
genes like me logo Genes that share ontologies with FCGBP: view

Phenotypes for FCGBP Gene

genes like me logo Genes that share phenotypes with FCGBP: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGBP Gene

Localization for FCGBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGBP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGBP Gene COMPARTMENTS Subcellular localization image for FCGBP gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for FCGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FCGBP: view

Pathways & Interactions for FCGBP Gene

SuperPathways for FCGBP Gene

No Data Available

Interacting Proteins for FCGBP Gene

Selected Interacting proteins: Q9Y6R7-FCGBP_HUMAN for FCGBP Gene via I2D

Symbol External ID(s) Details
MLH1

Gene Ontology (GO) - Biological Process for FCGBP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FCGBP Gene

Drugs & Compounds for FCGBP Gene

No Compound Related Data Available

Transcripts for FCGBP Gene

mRNA/cDNA for FCGBP Gene

Unigene Clusters for FCGBP Gene

Fc fragment of IgG binding protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGBP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGBP Gene

No ASD Table

Relevant External Links for FCGBP Gene

GeneLoc Exon Structure for
FCGBP
ECgene alternative splicing isoforms for
FCGBP

Expression for FCGBP Gene

mRNA expression in normal human tissues for FCGBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGBP Gene

This gene is overexpressed in Colon - Transverse (x22.4), Thyroid (x6.9), and Small Intestine - Terminal Ileum (x6.6).

Protein differential expression in normal tissues from HIPED for FCGBP Gene

This gene is overexpressed in Vitreous humor (14.6), Rectum (13.2), Fetal gut (11.8), Pancreatic juice (10.1), Colon (8.8), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCGBP Gene



SOURCE GeneReport for Unigene cluster for FCGBP Gene Hs.111732

mRNA Expression by UniProt/SwissProt for FCGBP Gene

Q9Y6R7-FCGBP_HUMAN
Tissue specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).
genes like me logo Genes that share expression patterns with FCGBP: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein tissue co-expression partners for FCGBP Gene

Orthologs for FCGBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCGBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCGBP 35
  • 77.48 (n)
  • 72.23 (a)
dog
(Canis familiaris)
Mammalia FCGBP 35
  • 77.47 (n)
  • 72.17 (a)
mouse
(Mus musculus)
Mammalia Fcgbp 35
  • 73.96 (n)
  • 70.48 (a)
Fcgbp 16
chimpanzee
(Pan troglodytes)
Mammalia FCGBP 35
  • 98.29 (n)
  • 97.9 (a)
rat
(Rattus norvegicus)
Mammalia Fcgbp 35
  • 73.49 (n)
  • 69.8 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fcgbp 35
  • 49.46 (n)
  • 39.95 (a)
Str.15640 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-65b12.6 35
  • 46.6 (n)
  • 38.97 (a)
Species with no ortholog for FCGBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FCGBP Gene

ENSEMBL:
Gene Tree for FCGBP (if available)
TreeFam:
Gene Tree for FCGBP (if available)

Paralogs for FCGBP Gene

(2) SIMAP similar genes for FCGBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FCGBP: view

No data available for Paralogs for FCGBP Gene

Variants for FCGBP Gene

Sequence variations from dbSNP and Humsavar for FCGBP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs759122 -- 39,867,457(+) gaaca(C/T)agata intron-variant
rs759644 -- 1(+) TACTC(A/G)GAAGG intron-variant
rs1053716 -- 39,863,379(-) CTTTT(C/T)TGGGT utr-variant-3-prime
rs1807381 -- 1(-) CAGAA(A/G)CCCTC intron-variant
rs4802065 -- 39,911,503(-) ACTAA(A/G)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCGBP Gene

Variant ID Type Subtype PubMed ID
dgv1082e1 CNV Complex 17122850
nsv9725 CNV Gain+Loss 18304495
nsv2483 CNV Loss 18451855
nsv509742 CNV Insertion 20534489
nsv510766 CNV Loss 20534489
nsv2484 CNV Insertion 18451855
nsv482218 CNV Gain 20164927
nsv176 CNV Insertion 15895083
esv21806 CNV Gain+Loss 19812545
esv2660568 CNV Deletion 23128226
esv1006063 CNV Gain 20482838
esv2718556 CNV Deletion 23290073
nsv436744 CNV Insertion 17901297
nsv471484 CNV Duplication 19718026
nsv177 CNV Loss 15895083
esv2718557 CNV Deletion 23290073
nsv442460 CNV CNV 18776908
esv1010625 CNV Loss 20482838
esv990421 CNV Gain 20482838
esv2676931 CNV Deletion 23128226
nsv2485 CNV Insertion 18451855

Variation tolerance for FCGBP Gene

Residual Variation Intolerance Score: 99.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 28.93; 99.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGBP Gene

HapMap Linkage Disequilibrium report
FCGBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGBP Gene

Disorders for FCGBP Gene

Relevant External Links for FCGBP

Genetic Association Database (GAD)
FCGBP
Human Genome Epidemiology (HuGE) Navigator
FCGBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGBP
genes like me logo Genes that share disorders with FCGBP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCGBP Gene

Publications for FCGBP Gene

  1. Downregulation of IgG Fc binding protein (Fc gammaBP) in prostate cancer. (PMID: 17938577) Gazi M.H. … Young C.Y. (Cancer Biol. Ther. 2008) 23 67
  2. The presence of keratin 5 as an IgG Fc binding protein in human corneal epithelium. (PMID: 15109920) Endo K. … Kinoshita S. (Exp. Eye Res. 2004) 23 67
  3. Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (PMID: 12208673) O'Donovan N. … Marti U. (J. Endocrinol. 2002) 23 67
  4. Novel goblet cell gene related to IgGFcgammaBP is regulated in adapting gut after small bowel resection. (PMID: 11052998) Rubin D.C. … Levin M.S. (Am. J. Physiol. Gastrointest. Liver Physiol. 2000) 23 67
  5. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. (PMID: 9182547) Harada N. … Morikawa M. (J. Biol. Chem. 1997) 2 67

Products for FCGBP Gene

Sources for FCGBP Gene

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