Aliases for FCGBP Gene
Aliases for FCGBP Gene
External Ids for FCGBP Gene
- HGNC: 13572
- Entrez Gene: 8857
- Ensembl: ENSG00000275395
- UniProtKB: Q9Y6R7
Previous GeneCards Identifiers for FCGBP Gene
- GC19M041007
- GC19M040745
- GC19M045030
- GC19M045045
- GC19M040353
Summaries for FCGBP Gene
GeneCards Summary for FCGBP Gene
FCGBP (Fc Fragment Of IgG Binding Protein) is a Protein Coding gene. An important paralog of this gene is ZAN.
UniProtKB/Swiss-Prot for FCGBP Gene
-
May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGBP Gene
Genomics for FCGBP Gene
Regulatory Elements for FCGBP Gene
Enhancers for FCGBP Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCGBP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCGBP gene promoter:
Regulatory Element Products
Genomic Location for FCGBP Gene
- Chromosome:
- 19
- Start:
- 39,863,323 bp from pter
- End:
- 39,934,626 bp from pter
- Size:
- 71,304 bases
- Orientation:
- Minus strand
Genomic View for FCGBP Gene
Genes around FCGBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
FCGBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCGBP Gene
Proteins for FCGBP Gene
-
Protein details for FCGBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6R7-FCGBP_HUMAN
- Recommended name:
- IgGFc-binding protein
- Protein Accession:
- Q9Y6R7
- O95784
Protein attributes for FCGBP Gene
- Size:
- 5405 amino acids
- Molecular mass:
- 572017 Da
- Quaternary structure:
-
- Interacts with the Fc portion of IgG and with MUC2.
Protein Expression for FCGBP Gene
Post-translational modifications for FCGBP Gene
Other Protein References for FCGBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FCGBP
-
Abcam antibodies for FCGBP
-
Cloud-Clone Corp. Antibodies for FCGBP
- Invitrogen Antibodies for FCGBP
- antibodies-online Antibodies for FCGBP: See all 18
- GeneTex FCGBP antibody for FCGBP
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FCGBP
- Origene Custom Protein Services for FCGBP
- Novus Biologicals proteins for FCGBP
-
Cloud-Clone Corp. Proteins for FCGBP
- antibodies-online Proteins for FCGBP: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FCGBP
No data available for DME Specific Peptides for FCGBP Gene
Domains & Families for FCGBP Gene
Protein Domains for FCGBP Gene
Suggested Antigen Peptide Sequences for FCGBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6R7- Domain:
-
- The N-terminal IgGFc-binding region is primate-specific.
No data available for Gene Families for FCGBP Gene
Function for FCGBP Gene
Molecular function for FCGBP Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19432394 |
Phenotypes for FCGBP Gene
- GenomeRNAi human phenotypes for FCGBP:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Synthetic lethal with Ras
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
Animal Model Products
-
Taconic Biosciences Mouse Models for FCGBP
-
ViGene Biosciences lentiviral particle packaged cDNA for FCGBP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGBP gene
- Search ViGene Biosciences for FCGBP
CRISPR Products
-
OriGene CRISPR knockouts for FCGBP
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCGBP
- GenScript: Design CRISPR guide RNA sequences for FCGBP
miRNA Products
- Search ViGene Biosciences for FCGBP
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCGBP
- Browse OriGene Inhibitory RNA Products For FCGBP
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGBP gene
Clone Products
Cell Line Products
-
Horizon Cell Lines for FCGBP
-
ViGene Biosciences adenoviral particle packaged cDNA for FCGBP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCGBP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGBP gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGBP Gene
Localization for FCGBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCGBP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Transcripts for FCGBP Gene
mRNA/cDNA for FCGBP Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (263) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCGBP Gene
CRISPR Products
-
OriGene CRISPR knockouts for FCGBP
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCGBP
- GenScript: Design CRISPR guide RNA sequences for FCGBP
miRNA Products
- Search ViGene Biosciences for FCGBP
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCGBP
- Browse OriGene Inhibitory RNA Products For FCGBP
-
ViGene Biosciences ready-to-package AAV shRNAs for FCGBP gene
Clone Products
Flow Cytometry Products
Expression for FCGBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T-Cytotoxic Cells Peripheral Blood
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for FCGBP Gene
This gene is overexpressed in Colon - Transverse (x22.4), Thyroid (x6.9), and Small Intestine - Terminal Ileum (x6.6).
This gene is overexpressed in Vitreous humor (14.6), Rectum (13.2), Fetal gut (11.8), Pancreatic juice (10.1), Colon (8.8), and Cervix (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCGBP Gene
NURSA nuclear receptor signaling pathways regulating expression of FCGBP Gene:
FCGBPSOURCE GeneReport for Unigene cluster for FCGBP Gene:
Hs.111732mRNA Expression by UniProt/SwissProt for FCGBP Gene:
Q9Y6R7-FCGBP_HUMAN
Tissue specificity:
Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).
Evidence on tissue expression from TISSUES for FCGBP Gene
- Intestine(4.9)
- Saliva(4.2)
- Bone marrow(4)
- Gall bladder(2.8)
- Thyroid gland(2.5)
- Stomach(2.2)
- Nervous system(2.2)
Primer Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGBP Gene
Orthologs for FCGBP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCGBP 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FCGBP 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FCGBP 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcgbp 34 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcgbp 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fcgbp 34 |
|
||
| Str.15640 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-65b12.6 34 |
|
- Species where no ortholog for FCGBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FCGBP Gene
(2) SIMAP similar genes for FCGBP Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for FCGBP Gene
Variants for FCGBP Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003921 | -- | 39,912,991(+) | AACAA(A/G)GCTCT | intron-variant | |
| rs1000020183 | -- | 39,916,767(+) | AACAT(A/T)CTGTG | intron-variant | |
| rs1000025526 | -- | 39,881,352(+) | CCCTG(A/G)GGTGA | intron-variant | |
| rs1000077835 | -- | 39,881,631(+) | CCTTC(C/G)TCCTG | intron-variant | |
| rs1000286362 | -- | 39,867,292(+) | GGTCA(A/G)TGAAA | intron-variant |
Residual Variation Intolerance Score:
99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
28.93;
99.87% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCGBP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGBP Gene
Disorders for FCGBP Gene
Relevant External Links for FCGBP
No disorders were found for FCGBP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCGBP Gene
Publications for FCGBP Gene
- Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (PMID: 12208673) O'Donovan N. … Marti U. (J. Endocrinol. 2002) 3 4 22 64
- Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. (PMID: 9182547) Harada N. … Morikawa M. (J. Biol. Chem. 1997) 2 3 4 64
- Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PMID: 19956635) Holmes M.V. … Casas J.P. (PLoS ONE 2009) 3 46 64
- Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (PMID: 19432394) Johansson M.E.V. … Hansson G.C. (J. Proteome Res. 2009) 3 4 64
- Downregulation of IgG Fc binding protein (Fc gammaBP) in prostate cancer. (PMID: 17938577) Gazi M.H. … Young C.Y. (Cancer Biol. Ther. 2008) 3 22 64
Products for FCGBP Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FCGBP
- Origene Custom Protein Services for FCGBP
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCGBP
- Browse OriGene Inhibitory RNA Products For FCGBP
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for FCGBP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FCGBP
- GenScript: Next-day shipping cDNA ORF clone for FCGBP in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FCGBP
- GenScript Custom Assay Services for FCGBP
- GenScript Custom overexpressing Cell Line Services for FCGBP
- GenScript: Design CRISPR guide RNA sequences for FCGBP
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FCGBP
- Browse Sino Biological cDNA Clones
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- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FCGBP
- Novus Biologicals proteins for FCGBP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for FCGBP
- Cloud-Clone Corp. Proteins for FCGBP
- Cloud-Clone Corp Assay Kits for FCGBP
- Taconic Biosciences Mouse Models for FCGBP
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FCGBP
- antibodies-online Antibodies for FCGBP: See all 18
- antibodies-online Kits for FCGBP: See all 9
- antibodies-online Proteins for FCGBP: See all 3
- Search antibodies-online for peptides
- GeneTex FCGBP antibody for FCGBP
- Search GeneTex for Proteins for FCGBP
- ViGene Biosciences adenoviral particle packaged cDNA for FCGBP gene
- ViGene Biosciences lentiviral particle packaged cDNA for FCGBP gene
- ViGene Biosciences ready-to-package AAV shRNAs for FCGBP gene
- Search ViGene Biosciences for FCGBP
- Horizon Cell Lines for FCGBP
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCGBP
- VectorBuilder custom plasmid, inducible vectors for FCGBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCGBP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCGBP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer