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FCGBP Gene

protein-coding   GIFtS: 50
GCID: GC19M040353

Fc Fragment Of IgG Binding Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Fragment Of IgG Binding Protein1 2     FC(GAMMA)BP2
Human Fc Gamma BP1 2     fcgammaBP2
IgG Fc Binding Protein1 2     IgGFc-Binding Protein2
Fcgamma-Binding Protein Antigen2 3     FcgammaBP3

External Ids:    HGNC: 135721   Entrez Gene: 88572   Ensembl: ENSG000000909207   UniProtKB: Q9Y6R73   

Export aliases for FCGBP gene to outside databases

Previous GC identifers: GC19M041007 GC19M040745 GC19M045030 GC19M045045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FCGBP Gene:
FCGBP (Fc fragment of IgG binding protein) is a protein-coding gene. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7
Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa

Gene Wiki entry for FCGBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCGBP gene promoter:
         AREB6   NF-1   Elk-1   NRSF form 1   Tal-1beta   ITF-2   NRSF form 2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGBP promoter sequence
   Search Chromatin IP Primers for FCGBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCGBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

FCGBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGBP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040353:  view genomic region     (about GC identifiers)

Start:
40,353,963 bp from pter      End:
40,440,533 bp from pter
Size:
86,571 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7 (See protein sequence)
Recommended Name: IgGFc-binding protein precursor  
Size: 5405 amino acids; 572017 Da
Subunit: Interacts with the Fc portion of IgG and with MUC2
Secondary accessions: O95784

Explore the universe of human proteins at neXtProt for FCGBP: NX_Q9Y6R7

Explore proteomics data for FCGBP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn75, Asn91, Asn1317, Asn1743, Asn2138, Asn2518, Asn3719, Asn4145, Asn4540
  • Modification sites at PhosphoSitePlus

  • See FCGBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003881.2  
    ENSEMBL proteins: 
     ENSP00000221347   ENSP00000469477  

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    antibodies-online antibodies for FCGBP (13 products) 

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    antibodies-online kits for FCGBP (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR014853 Unchr_dom_Cys-rich
     IPR002919 TIL_dom
     IPR025615 TILa_dom
     IPR001007 VWF_C
     IPR001846 VWF_type-D

    Graphical View of Domain Structure for InterPro Entry Q9Y6R7

    ProtoNet protein and cluster: Q9Y6R7

    3 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like


    UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7
    Domain: The N-terminal IgGFc-binding region is primate-specific
    Similarity: Contains 12 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 13 VWFD domains


    Find genes that share domains with FCGBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGBP_HUMAN, Q9Y6R7
    Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19432394
         
    Find genes that share ontologies with FCGBP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FCGBP:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Fcgbp (no phenotypes)

    Find genes that share phenotypes with FCGBP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FCGBP

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCGBP_HUMAN, Q9Y6R7: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular4
    plasma membrane3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005737cytoplasm ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with FCGBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCGBP
    Interactions:

        Search GeneGlobe Interaction Network for FCGBP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FCGBP (Q9Y6R73 ENSP000002213474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406923I2D: score=1 
    ADAMTSL4ENSP000002716434STRING: ENSP00000271643
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCGBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCGBP gene: 
    NM_003890.2  

    Unigene Cluster for FCGBP:

    Fc fragment of IgG binding protein
    Hs.111732  [show with all ESTs]
    Unigene Representative Sequence: NM_003890
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221347(uc002omp.4) ENST00000595713 ENST00000601713
    miRNA
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    Additional mRNA sequence: D84239.1 

    7 DOTS entries:

    DT.414185  DT.97797583  DT.97847828  DT.121471285  DT.121471272  DT.97816593  DT.91744895 

    Selected AceView cDNA sequences (see all 263):

    BF725130 AI983612 AI659375 CA393064 BE855446 AI347176 AW197398 BM781657 
    BU731683 BU169169 AA593923 BM765222 BE855430 BU150169 AI869939 AW087283 
    BE501429 BF001909 BF525929 AI361395 AW470109 AI817727 AI380162 BM310289 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FCGBP (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^
    SP1:                                -     -     -     -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for FCGBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCGBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTCCTACC
    FCGBP Expression
    About this image


    FCGBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             T-Cytotoxic Cells Peripheral Blood
     
     Thyroid (Endocrine System)
     
     Colon (Gastrointestinal Tract)
     
     Gall Bladder (Hepatobiliary System)
     
     Stomach (Gastrointestinal Tract)
    FCGBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCGBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111732

    UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7
    Tissue specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in
    thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein
    level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FCGBP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgbp1 , 5 Fc fragment of IgG binding protein1, 5 73.96(n)1
    70.48(a)1
      7 (16.26 cM)5
    2153841  NM_001122603.11  NP_001116075.11 
     280712365 
    chicken
    (Gallus gallus)
    Aves FCGBP6
    Fc fragment of IgG binding protein
    42(a)
    1 ↔ 1
    JH375515.1(11675-21757)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    48(a)
    40(a)
    (see all 5)
    many → 1
    many → 1
    (see all 5)
    AAWZ02039284(1232-8269)
    GL343276.1(662911-692046)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156402 Transcribed sequence with weak similarity to protein more 77.78(n)    BX710528.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-65b12.61 si:dkey-65b12.6 46.6(n)
    38.97(a)
      569718  XM_693120.6  XP_698212.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta cv-26
    crossveinless 2
    22(a)
    1 → many
    2R(17242520-17266967)


    ENSEMBL Gene Tree for FCGBP (if available)
    TreeFam Gene Tree for FCGBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCGBP gene
    MUC5AC2  ZAN2  TECTA2  MUC22  OTOG2  OTOGL2  MUC62  MUC192  
    VWF2  BMPER2  
    2 SIMAP similar genes for FCGBP using alignment to 2 protein entries:     FCGBP_HUMAN (see all proteins):
    VWF    ZAN

    Find genes that share paralogs with FCGBP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FCGBP
    PGOHUM00000234669


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCGBP (see all 2354)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343487791,2
    C,F--40353508(+) CACTGC/TAGCCT 1 -- int16Minor allele frequency- T:0.27NA EA 248
    rs351754231,2
    C,F--40353546(+) CACCTT/CAGCCT 1 -- int18Minor allele frequency- C:0.22NA CSA WA EA 368
    rs347973951,2
    C,F--40353576(+) AGGCAC/AGTGCC 1 -- int17Minor allele frequency- A:0.36NA CSA 14
    rs1113811961,2
    C,F--40353704(+) GGATTG/ACAAGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1507424511,2
    --40353719(+) GCCACC/TGTGCC 1 -- int10--------
    rs1816764721,2
    --40353728(+) CCTGGC/TCATTT 1 -- int10--------
    rs1380064001,2
    --40353748(+) TCCATC/GCACTC 1 -- int10--------
    rs1855350341,2
    --40353777(+) TCATCC/TTCCTA 1 -- int10--------
    rs1903989141,2
    --40353814(+) CACCCA/GTCCAT 1 -- int10--------
    rs762703431,2
    C--40353864(+) GCCCCC/TAATAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for FCGBP (40353963 - 40440533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCGBP (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660568CNV Deletion23128226
    esv2718557CNV Deletion23290073
    esv2718556CNV Deletion23290073
    esv2676931CNV Deletion23128226
    nsv471484CNV Duplication19718026
    nsv436744CNV Insertion17901297
    nsv509742CNV Insertion20534489
    nsv2485CNV Insertion18451855
    nsv176CNV Insertion15895083
    nsv2484CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCGBP
    DNA2.0 Custom Variant and Variant Library Synthesis for FCGBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FCGBP           About GenesLikeMe

    Genetic Association Database (GAD): FCGBP
    Human Genome Epidemiology (HuGE) Navigator: FCGBP (2 documents)

    Export disorders for FCGBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCGBP gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with FCGBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. (PubMed id 9182547)1, 2, 3 Harada N.... Morikawa M. (J. Biol. Chem. 1997)
    2. Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (PubMed id 12208673)1, 2, 9 O'Donovan N.... Marti U. (J. Endocrinol. 2002)
    3. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (PubMed id 19432394)1, 2 Johansson M.E.V.... Hansson G.C. (J. Proteome Res. 2009)
    4. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases. (PubMed id 11600203)1, 2 Kobayashi K.... Morikawa M. (Immunol. Lett. 2001)
    10. Downregulation of IgG Fc binding protein (Fc gammaBP) in prostate cancer. (PubMed id 17938577)1, 9 Gazi M.H....Young C.Y. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8857 HGNC: 13572 AceView: FCGBP Ensembl:ENSG00000090920 euGenes: HUgn8857
    ECgene: FCGBP H-InvDB: FCGBP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCGBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCGBP gene:
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    GeneCards and IP:
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