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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCGBP Gene

protein-coding   GIFtS: 48
GCID: GC19M040353

Fc Fragment Of IgG Binding Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fc Fragment Of IgG Binding Protein1 2     FC(GAMMA)BP2
Human Fc Gamma BP1 2     fcgammaBP2
IgG Fc Binding Protein1 2     IgGFc-Binding Protein2
Fcgamma-Binding Protein Antigen2 3     FcgammaBP3

External Ids:    HGNC: 135721   Entrez Gene: 88572   Ensembl: ENSG000000909207   UniProtKB: Q9Y6R73   
ORGUL members:         
NONCODE14:n338599      

Export aliases for FCGBP gene to outside databases

Previous GC identifers: GC19M041007 GC19M040745 GC19M045030 GC19M045045


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FCGBP Gene: 
FCGBP (Fc fragment of IgG binding protein) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with FCGBP include thyroid adenoma, and thyroiditis. GO annotations related to this gene include protein binding. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7
Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa

Gene Wiki entry for FCGBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCGBP gene promoter:
         AREB6   NF-1   Elk-1   NRSF form 1   Tal-1beta   ITF-2   NRSF form 2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCGBP promoter sequence
   Search SABiosciences Chromatin IP Primers for FCGBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCGBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

FCGBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGBP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040353:  view genomic region     (about GC identifiers)

Start:
40,353,963 bp from pter      End:
40,440,533 bp from pter
Size:
86,571 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7 (See protein sequence)
Recommended Name: IgGFc-binding protein precursor  
Size: 5405 amino acids; 572017 Da
Subunit: Interacts with the Fc portion of IgG and with MUC2
Subcellular location: Secreted (Probable)
Secondary accessions: O95784

Explore the universe of human proteins at neXtProt for FCGBP: NX_Q9Y6R7

Explore proteomics data for FCGBP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6R7

  • FCGBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FCGBP Protein Expression
    REFSEQ proteins: NP_003881.2  
    ENSEMBL proteins: 
     ENSP00000221347   ENSP00000469477  

    Human Recombinant Protein Products for FCGBP: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IDA--

    FCGBP for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR014853 Unchr_dom_Cys-rich
     IPR002919 TIL_dom
     IPR025615 TILa_dom
     IPR001007 VWF_C
     IPR001846 VWF_type-D

    Graphical View of Domain Structure for InterPro Entry Q9Y6R7

    ProtoNet protein and cluster: Q9Y6R7

    3 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like


    UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7
    Domain: The N-terminal IgGFc-binding region is primate-specific
    Similarity: Contains 12 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 13 VWFD domains


    FCGBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCGBP_HUMAN, Q9Y6R7
    Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19432394
         
    FCGBP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FCGBP:
     Synthetic lethal with Ras 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCGBP

    1 Interacting protein for FCGBP (Q9Y6R73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406923I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCGBP

    Search CenterWatch for drugs/clinical trials and news about FCGBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FCGBP gene: 
    NM_003890.2  

    Unigene Cluster for FCGBP:

    Fc fragment of IgG binding protein
    Hs.111732  [show with all ESTs]
    Unigene Representative Sequence: NM_003890
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221347(uc002omp.4) ENST00000595713 ENST00000601713
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: D84239.1 

    7 DOTS entries:

    DT.414185  DT.97797583  DT.97847828  DT.121471285  DT.121471272  DT.97816593  DT.91744895 

    24/263 AceView cDNA sequences (see all 263):

    AI683795 AA588051 AI652793 AA552662 AA523545 BM753437 BF725130 AI983612 
    AI659375 CA393064 BE855446 BX480477 AI371858 BM708450 BF061814 BM773169 
    BM826390 AA573915 AI347176 AW197398 BM781657 BU731683 BU169169 AA593923 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for FCGBP (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^
    SP1:                                -     -     -     -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for FCGBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCGBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTCCTACC
    FCGBP Expression
    About this image


    See FCGBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCGBP

    SOURCE GeneReport for Unigene cluster: Hs.111732

    UniProtKB/Swiss-Prot: FCGBP_HUMAN, Q9Y6R7
    Tissue specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in
    thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein
    level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FCGBP gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcgbp1 , 5 Fc fragment of IgG binding protein1, 5 73.93(n)1
    70.44(a)1
      7 (16.26 cM)5
    2153841  NM_001122603.11  NP_001116075.11 
     280712365 
    chicken
    (Gallus gallus)
    Aves FCGBP6
    --
    --
    42(a)
    37(a)
    1 ↔ 1
    possible ortholog
    JH375515.1(11675-21757)
    AADN03018760.1(360-10879)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    40(a)
    26(a)
    (see all 3)
    possible ortholog
    many → 1
    (see all 3)
    GL343276.1(756238-798798)
    GL343276.1(572353-753685)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156402 Transcribed sequence with weak similarity to protein more 77.78(n)    BX710528.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FCGBP6
    si:ch211-284d12.36
    (see all 3)
    si:ch211-284d12.3
    (see all 3)
    43(a)
    25(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    Zv9_NA719(297-19158)
    2(47392211-47413529)


    ENSEMBL Gene Tree for FCGBP (if available)
    TreeFam Gene Tree for FCGBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCGBP gene
    MUC5AC2  ZAN2  TECTA2  OTOG2  OTOGL2  MUC5B2  MUC62  MUC192  
    VWF2  BMPER2  
    2 SIMAP similar genes for FCGBP using alignment to 2 protein entries:     FCGBP_HUMAN (see all proteins):
    VWF    ZAN

    FCGBP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FCGBP
    PGOHUM00000234669


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2354 SNPs in FCGBP are shown (see all 2354)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0289064
    ----see VAR_0289062 N D mis40--------
    VAR_0289144
    ----see VAR_0289142 G D mis40--------
    VAR_0289074
    ----see VAR_0289072 E D mis40--------
    VAR_0289104
    ----see VAR_0289102 V A mis40--------
    VAR_0289094
    ----see VAR_0289092 A V mis40--------
    VAR_0289154
    ----see VAR_0289152 G S mis40--------
    VAR_0289124
    ----see VAR_0289122 H Q mis40--------
    VAR_0289134
    ----see VAR_0289132 V A mis40--------
    VAR_0289114
    ----see VAR_0289112 G S mis40--------
    VAR_0289084
    ----see VAR_0289082 E K mis40--------

    HapMap Linkage Disequilibrium report for FCGBP (40353963 - 40440533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for FCGBP (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660568CNV Deletion23128226
    esv2718557CNV Deletion23290073
    esv2718556CNV Deletion23290073
    esv2676931CNV Deletion23128226
    nsv471484CNV Duplication19718026
    nsv436744CNV Insertion17901297
    nsv509742CNV Insertion20534489
    nsv2485CNV Insertion18451855
    nsv176CNV Insertion15895083
    nsv2484CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    10 diseases for FCGBP:    About MalaCards
    thyroid adenoma    thyroiditis    adenoma    hepatitis b
    rheumatoid arthritis    arthritis    hepatitis    gastric cancer
    prostate cancer    prostatitis


    FCGBP for disorders           About GeneDecksing

    Genetic Association Database (GAD): FCGBP
    Human Genome Epidemiology (HuGE) Navigator: FCGBP (2 documents)

    Export disorders for FCGBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCGBP gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with FCGBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. (PubMed id 9182547)1, 2, 3 Harada N.... Morikawa M. (1997)
    2. Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (PubMed id 12208673)1, 2, 9 O'Donovan N.... Marti U. (2002)
    3. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (PubMed id 19432394)1, 2 Johansson M.E.V.... Hansson G.C. (2009)
    4. Fulfilling the promise of personalized medicine? Syst ematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (2009)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    9. Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases. (PubMed id 11600203)1, 2 Kobayashi K.... Morikawa M. (2001)
    10. Downregulation of IgG Fc binding protein (Fc gammaBP) in prostate cancer. (PubMed id 17938577)1, 9 Gazi M.H....Young C.Y. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8857 HGNC: 13572 AceView: FCGBP Ensembl:ENSG00000090920 euGenes: HUgn8857
    ECgene: FCGBP H-InvDB: FCGBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCGBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCGBP gene:
    Search GeneIP for patents involving FCGBP

    GeneCards and IP:
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