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Aliases for FCF1 Gene

Aliases for FCF1 Gene

  • FCF1 RRNA-Processing Protein 2 3 5
  • C14orf111 3 4
  • FCF1 Small Subunit (SSU) Processome Component Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 111 2
  • RRNA-Processing Protein FCF1 Homolog 3
  • FCF1 Small Subunit 3
  • CGI-35 3
  • UTP24 3
  • Bka 3

External Ids for FCF1 Gene

Previous HGNC Symbols for FCF1 Gene

  • C14orf111

Previous GeneCards Identifiers for FCF1 Gene

  • GC14P074250
  • GC14P075179

Summaries for FCF1 Gene

GeneCards Summary for FCF1 Gene

FCF1 (FCF1 RRNA-Processing Protein) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for FCF1 Gene

  • Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.

Gene Wiki entry for FCF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCF1 Gene

Genomics for FCF1 Gene

Regulatory Elements for FCF1 Gene

Enhancers for FCF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G074591 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.4 -116.9 -116888 9.5 ATF1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF766 ELK1 FCF1 ELMSAN1 PNMA1 LIN52 NEK9 EIF2B2 AREL1 NPC2 LTBP2 LOC101928352
GH14G074647 1.3 Ensembl ENCODE dbSUPER 21.4 -64.5 -64493 3.1 ESRRA TAL1 TEAD4 FEZF1 ZIC2 TCF12 ZNF316 GATA2 NCOR1 FOXK2 FCF1 ELMSAN1 NEK9 LTBP2 ENSG00000258559 AREL1 ENSG00000222604 DLST LOC105370567
GH14G074564 2 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -142.6 -142567 11.5 PKNOX1 FOXA2 SIN3A ARID4B FEZF1 ZBTB7B YY1 ZNF416 FOS ZNF263 ELMSAN1 LTBP2 ENSG00000259005 FCF1 ENSG00000258559 LIN52 SYNDIG1L PROX2 NPC2 DLST
GH14G074610 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -96.5 -96534 11.8 PKNOX1 ARNT WRNIP1 SIN3A ARID4B DMAP1 ZBTB7B YY1 ZNF143 FOS FCF1 ENSG00000222604 SYNDIG1L FOS AREL1 PGF RPS6KL1 ENSG00000259005 EIF2B2 LTBP2
GH14G075273 1.8 FANTOM5 ENCODE dbSUPER 10.7 +564.7 564704 9.2 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 ZNF207 ENSG00000258559 FOS PROX2 ENSG00000258646 IFT43 FCF1 ENSG00000258740 JDP2 FLVCR2 NEK9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCF1 on UCSC Golden Path with GeneCards custom track

Promoters for FCF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070780 -217 1801 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ZHX2

Genomic Location for FCF1 Gene

Chromosome:
14
Start:
74,713,117 bp from pter
End:
74,738,620 bp from pter
Size:
25,504 bases
Orientation:
Plus strand

Genomic View for FCF1 Gene

Genes around FCF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCF1 Gene

Proteins for FCF1 Gene

  • Protein details for FCF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y324-FCF1_HUMAN
    Recommended name:
    rRNA-processing protein FCF1 homolog
    Protein Accession:
    Q9Y324
    Secondary Accessions:
    • Q86TW8
    • Q8TBL8

    Protein attributes for FCF1 Gene

    Size:
    198 amino acids
    Molecular mass:
    23370 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62599.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FCF1 Gene

Post-translational modifications for FCF1 Gene

  • Ubiquitination at isoforms=137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCF1 Gene

Domains & Families for FCF1 Gene

Protein Domains for FCF1 Gene

Suggested Antigen Peptide Sequences for FCF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y324

UniProtKB/Swiss-Prot:

FCF1_HUMAN :
  • Belongs to the UTP23/FCF1 family. FCF1 subfamily.
Family:
  • Belongs to the UTP23/FCF1 family. FCF1 subfamily.
genes like me logo Genes that share domains with FCF1: view

No data available for Gene Families for FCF1 Gene

Function for FCF1 Gene

Molecular function for FCF1 Gene

UniProtKB/Swiss-Prot Function:
Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.

Gene Ontology (GO) - Molecular Function for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FCF1: view
genes like me logo Genes that share phenotypes with FCF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCF1 Gene

Localization for FCF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCF1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCF1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IBA --
GO:0032040 small-subunit processome IEA,IBA --
genes like me logo Genes that share ontologies with FCF1: view

Pathways & Interactions for FCF1 Gene

genes like me logo Genes that share pathways with FCF1: view

Gene Ontology (GO) - Biological Process for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with FCF1: view

No data available for SIGNOR curated interactions for FCF1 Gene

Drugs & Compounds for FCF1 Gene

No Compound Related Data Available

Transcripts for FCF1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCF1 Gene

No ASD Table

Relevant External Links for FCF1 Gene

GeneLoc Exon Structure for
FCF1
ECgene alternative splicing isoforms for
FCF1

Expression for FCF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCF1 Gene

Protein differential expression in normal tissues from HIPED for FCF1 Gene

This gene is overexpressed in Lung (51.5) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FCF1 Gene



Protein tissue co-expression partners for FCF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCF1 Gene:

FCF1

SOURCE GeneReport for Unigene cluster for FCF1 Gene:

Hs.579828
genes like me logo Genes that share expression patterns with FCF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCF1 Gene

Orthologs for FCF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FCF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCF1 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
-- 35
  • 95 (a)
OneToMany
FCF1 34
  • 94.11 (n)
cow
(Bos Taurus)
Mammalia FCF1 34 35
  • 94.61 (n)
oppossum
(Monodelphis domestica)
Mammalia FCF1 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcf1 34
  • 90.07 (n)
mouse
(Mus musculus)
Mammalia Fcf1 34 16 35
  • 89.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FCF1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FCF1 34 35
  • 78.45 (n)
lizard
(Anolis carolinensis)
Reptilia FCF1 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fcf1 34
  • 76.99 (n)
Str.1834 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20881 34
zebrafish
(Danio rerio)
Actinopterygii fcf1 34
  • 76.43 (n)
FCF1 35
  • 76 (a)
OneToOne
wufc51c12 34
fruit fly
(Drosophila melanogaster)
Insecta Bka 34 35
  • 65.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009504 34
  • 60.91 (n)
worm
(Caenorhabditis elegans)
Secernentea F30A10.9 34 35
  • 61.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FCF1 34 35 37
  • 60.82 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL102W 34
  • 59.22 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07018g 34
  • 59.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46230 34
  • 65.81 (n)
soybean
(Glycine max)
eudicotyledons Gma.13234 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2007 34
rice
(Oryza sativa)
Liliopsida Os06g0158600 34
  • 64.29 (n)
Os.33206 34
wheat
(Triticum aestivum)
Liliopsida Ta.9069 34
corn
(Zea mays)
Liliopsida Zm.10381 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6957 35
  • 76 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC32H8.04c 34
  • 61.38 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04159 34
  • 55.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4808 34
Species where no ortholog for FCF1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FCF1 Gene

ENSEMBL:
Gene Tree for FCF1 (if available)
TreeFam:
Gene Tree for FCF1 (if available)

Paralogs for FCF1 Gene

No data available for Paralogs for FCF1 Gene

Variants for FCF1 Gene

Sequence variations from dbSNP and Humsavar for FCF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000124777 -- 74,712,467(+) GAAAA(A/G)AGCTA intron-variant, upstream-variant-2KB
rs1000189115 -- 74,718,623(+) TGCAT(A/G)CTGCC intron-variant
rs1000231869 -- 74,718,909(+) AATCC(C/T)AGTGC intron-variant
rs1000337272 -- 74,724,604(+) TTTAG(G/T)GTAAC intron-variant
rs1000727506 -- 74,718,270(+) TATAG(C/T)CCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCF1 Gene

Variant ID Type Subtype PubMed ID
nsv477903 CNV novel sequence insertion 20440878
nsv832831 CNV loss 17160897
nsv832832 CNV gain+loss 17160897

Variation tolerance for FCF1 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCF1 Gene

Disorders for FCF1 Gene

Relevant External Links for FCF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCF1

No disorders were found for FCF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCF1 Gene

Publications for FCF1 Gene

  1. Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. (PMID: 16762320) Rempola B. … Rytka J. (Biochem. Biophys. Res. Commun. 2006) 2 3 64
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for FCF1 Gene

Sources for FCF1 Gene

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