FCF1 Gene
protein-coding GIFtS: 50
GCID: GC14P075179
|
|
FCF1 small subunit (SSU) processome component homolog (S....(Previous name: chromosome 14 open reading frame 111 )
(Previous symbol: C14orf111)
| |
Aliases
for FCF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FCF1 Small Subunit (SSU) Processome Component Homolog (S. Cerevisiae)1 2 | | CGI-351 | | C14orf1111 2 3 | | Chromosome 14 Open Reading Frame 1111 | | Bka1 2 | | RRNA-Processing Protein FCF1 Homolog2 | | UTP241 2 | | |
Export aliases for FCF1 gene to outside databasesPrevious GC identifer: GC14P074250 |
Summaries
for FCF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FCF1_HUMAN, Q9Y324Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)
Gene Wiki entry for FCF1
|
Genomic Views
for FCF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCF1 gene promoter:
TBP RP58 C/EBPbeta AML1a Pax-5 NCX/Ncx Bach2 FOXD1 AREB6 TFIID
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.2FCF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P075179: view genomic region
(about GC identifiers)
Start:
|
75,179,847 bp from pter |
End:
|
75,203,394 bp from pter |
Size:
|
23,548 bases |
Orientation:
|
plus strand |
|
Proteins
for FCF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCF1_HUMAN, Q9Y324 (See
protein sequence)Recommended Name: rRNA-processing protein FCF1 homolog Size: 198 amino acids; 23370 Da
Subcellular location: Nucleus, nucleolus (By similarity)
Sequence caution: Sequence=CAD62599.1; Type=Erroneous initiation;
Secondary accessions: Q86TW8 Q8TBL8Explore the universe of human proteins at neXtProt for FCF1: NX_Q9Y324
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y324
FCF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057046.1
ENSEMBL proteins: ENSP00000450750 ENSP00000344393 ENSP00000451345 ENSP00000452415 ENSP00000444939 ENSP00000452497 ENSP00000452297
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
FCF1 for ontologies About GeneDecksing
FCF1 Antibody Products:
Assay Products for FCF1: |
Protein
Domains /
Families
for FCF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCF1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y324ProtoNet protein and cluster: Q9Y324 UniProtKB/Swiss-Prot: FCF1_HUMAN, Q9Y324Similarity: Belongs to the UTP23/FCF1 family. FCF1 subfamilySimilarity: Contains 1 PINc domain |
Function
for FCF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FCF1_HUMAN, Q9Y324Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FCF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCF1 |
4 GenomeRNAi human phenotypes for FCF1:
|
Pathways & Interactions
for FCF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for FCF1):
FCF1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/9 Interacting proteins for FCF1 (Q9Y3243 ENSP000003443934) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
IEA | -- |
FCF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FCF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FCF1
Search CenterWatch for drugs/clinical trials and news about FCF1
|
Transcripts
for FCF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCF1 gene: NM_015962.4 Unigene Clusters for FCF1: FCF1 small subunit (SSU) processome component homolog (S. cerevisiae) Hs.579828 [show with all ESTs], Hs.711584 Unigene Representative Sequences: BX647810, AK0570608 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000554590(uc001xqe.1) ENST00000341162(uc001xqf.1 uc001xqh.3 uc001xqi.3)
ENST00000556814 ENST00000554064 ENST00000534938 ENST00000553615 ENST00000553673
ENST00000554973
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FCF1 (NM_015962) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCF1 |
Additional cDNA sequence: AK057060.1 9 DOTS entries: DT.110617 DT.40197682 DT.91802988 DT.99938946 DT.120764240 DT.95265936 DT.40294170 DT.100781995 DT.100806110 24/93 AceView cDNA sequences (see all 93): BX375948 CB242025 AW207607 NM_015962 AI458738 CB266592 CR598081 BM699058 BC062726 AW069038 BX248271 BF939064 AA310320 N47824 BC080600 BQ028590 CB160865 BE218972 BX384522 N32600 BX489015 AI184760 CA439714 BC022361
GeneLoc Exon Structure
|
Expression
for FCF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCGAATGC
About this image
See FCF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCF1
SOURCE GeneReport for Unigene clusters: Hs.579828 Hs.711584
SABiosciences Custom PCR Arrays for FCF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCF1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCF1 |
Orthologs
for FCF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FCF1 gene from 9/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FCF11 |
FCF1 small subunit (SSU) processome component homolog more |
78.45(n)
90.91(a) |
|
423355 XM_421270.3 XP_421270.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FCF16 |
-- |
97(a) |
1 ↔ 1 |
1(22860717-22864405) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.208812 |
Xenopus laevis transcribed sequence with moderate similarity more |
87.89(n) |
|
BX852247.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc51c122 |
wufc51c12 |
80.22(n) |
|
325009 CK027871.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Bka1 |
Bekka |
65.97(n)
71.87(a) |
|
46032 NM_080128.3 NP_524867.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
F30A10.91 |
Protein F30A10.9 |
60.79(n)
59.59(a) |
|
172780 NM_060122.3 NP_492523.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
FCF1(YDR339C)4
FCF11 |
Putative PINc domain nuclease required for early cleavages more4
Fcf1p1 |
60.93(n)1
63.98(a)1 |
|
4(1150520-1149951)4
8519391, 4 NP_010626.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G462301 |
PIN domain-containing protein |
65.46(n)
67.01(a) |
|
819231 NM_130186.5 NP_566068.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.332062 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.18(n) |
|
AK059986.1 |
ENSEMBL Gene Tree for FCF1 (if available)
TreeFam Gene Tree for FCF1 (if available) |
Paralogs
for FCF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCF1 gene
2 SIMAP similar genes for FCF1 using alignment to 8 protein entries: FCF1_HUMAN (see all proteins):DKFZp686O2396 UTP23
FCF1 for paralogs About GeneDecksing
5/11 Pseudogenes.org Pseudogenes for FCF1 (see all 11)
PGOHUM00000244021 PGOHUM00000244521 PGOHUM00000237620 PGOHUM00000238123 PGOHUM00000245537
|
Genomic Variants
for FCF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCF1 (75179847 - 75203394 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FCF1
1 CNV: 4839 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCF1 |
|
Disorders
/ Diseases
for FCF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCF1 for disorders About GeneDecksing
4  diseases for FCF1: About MalaCardseumycotic mycetoma candida glabrata mycetoma malaria
Export disorders for FCF1 gene to outside databases
|
Publications
for FCF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCF1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FCF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. (PubMed id 16762320)1, 3 Rempola B....Rytka J. (2006)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S....Mann M. (2005)
- SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones. (PubMed id 15198809)1 Wellenreuther R....The German cDNA Consortium (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
|
External Searches for FCF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCF1 gene:
Search GeneIP for patents involving FCF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FCF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCF1 | | | OriGene Protein Over-expression Lysate for FCF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for FCF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCF1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FCF1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FCF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCF1 |
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