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Aliases for FCF1 Gene

Aliases for FCF1 Gene

  • FCF1 RRNA-Processing Protein 2 3 5
  • C14orf111 3 4
  • FCF1 Small Subunit (SSU) Processome Component Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 111 2
  • FCF1 Small Subunit 3
  • CGI-35 3
  • UTP24 3
  • Bka 3

External Ids for FCF1 Gene

Previous HGNC Symbols for FCF1 Gene

  • C14orf111

Previous GeneCards Identifiers for FCF1 Gene

  • GC14P074250
  • GC14P075179

Summaries for FCF1 Gene

GeneCards Summary for FCF1 Gene

FCF1 (FCF1 RRNA-Processing Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for FCF1 Gene

  • Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.

Gene Wiki entry for FCF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCF1 Gene

Genomics for FCF1 Gene

Regulatory Elements for FCF1 Gene

Enhancers for FCF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FCF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FCF1 Gene

74,713,117 bp from pter
74,738,620 bp from pter
25,504 bases
Plus strand

Genomic View for FCF1 Gene

Genes around FCF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCF1 Gene

Proteins for FCF1 Gene

  • Protein details for FCF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    rRNA-processing protein FCF1 homolog
    Protein Accession:
    Secondary Accessions:
    • Q86TW8
    • Q8TBL8

    Protein attributes for FCF1 Gene

    198 amino acids
    Molecular mass:
    23370 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD62599.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FCF1 Gene

Proteomics data for FCF1 Gene at MOPED

Post-translational modifications for FCF1 Gene

  • Ubiquitination at Lys 137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCF1 Gene

Domains & Families for FCF1 Gene

Protein Domains for FCF1 Gene

Suggested Antigen Peptide Sequences for FCF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PINc domain.
  • Belongs to the UTP23/FCF1 family. FCF1 subfamily.
  • Contains 1 PINc domain.
  • Belongs to the UTP23/FCF1 family. FCF1 subfamily.
genes like me logo Genes that share domains with FCF1: view

No data available for Gene Families for FCF1 Gene

Function for FCF1 Gene

Molecular function for FCF1 Gene

UniProtKB/Swiss-Prot Function:
Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.
genes like me logo Genes that share phenotypes with FCF1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCF1 Gene

Localization for FCF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCF1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for FCF1 Gene COMPARTMENTS Subcellular localization image for FCF1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for FCF1 Gene

Pathways & Interactions for FCF1 Gene

genes like me logo Genes that share pathways with FCF1: view

Pathways by source for FCF1 Gene

Gene Ontology (GO) - Biological Process for FCF1 Gene


No data available for SIGNOR curated interactions for FCF1 Gene

Drugs & Compounds for FCF1 Gene

No Compound Related Data Available

Transcripts for FCF1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FCF1 Gene

No ASD Table

Relevant External Links for FCF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCF1 Gene

mRNA expression in normal human tissues for FCF1 Gene

Protein differential expression in normal tissues from HIPED for FCF1 Gene

This gene is overexpressed in Lung (51.5) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FCF1 Gene

SOURCE GeneReport for Unigene cluster for FCF1 Gene Hs.579828

genes like me logo Genes that share expression patterns with FCF1: view

Protein tissue co-expression partners for FCF1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FCF1 Gene

Orthologs for FCF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FCF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FCF1 35
  • 94.61 (n)
  • 100 (a)
FCF1 36
  • 100 (a)
(Canis familiaris)
Mammalia FCF1 35
  • 94.11 (n)
  • 99.49 (a)
-- 36
  • 98 (a)
-- 36
  • 98 (a)
-- 36
  • 96 (a)
-- 36
  • 95 (a)
-- 36
  • 99 (a)
(Mus musculus)
Mammalia Fcf1 35
  • 89.39 (n)
  • 97.98 (a)
Fcf1 16
Fcf1 36
  • 98 (a)
(Pan troglodytes)
Mammalia FCF1 35
  • 99.66 (n)
  • 100 (a)
FCF1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fcf1 35
  • 90.07 (n)
  • 98.48 (a)
(Monodelphis domestica)
Mammalia FCF1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia FCF1 36
  • 68 (a)
(Gallus gallus)
Aves FCF1 35
  • 78.45 (n)
  • 90.91 (a)
FCF1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia FCF1 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fcf1 35
  • 76.99 (n)
  • 87.82 (a)
Str.1834 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20881 35
(Danio rerio)
Actinopterygii fcf1 35
  • 76.43 (n)
  • 88.38 (a)
wufc51c12 35
FCF1 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009504 35
  • 60.91 (n)
  • 67.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bka 35
  • 65.28 (n)
  • 70.47 (a)
Bka 36
  • 68 (a)
(Caenorhabditis elegans)
Secernentea F30A10.9 35
  • 61.31 (n)
  • 59.59 (a)
F30A10.9 36
  • 59 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL102W 35
  • 59.22 (n)
  • 62.23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07018g 35
  • 59.04 (n)
  • 60.64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FCF1 35
  • 60.82 (n)
  • 63.3 (a)
FCF1 36
  • 62 (a)
FCF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46230 35
  • 65.81 (n)
  • 68.04 (a)
(Glycine max)
eudicotyledons Gma.13234 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2007 35
(Oryza sativa)
Liliopsida Os.33206 35
Os06g0158600 35
  • 64.29 (n)
  • 69.39 (a)
(Triticum aestivum)
Liliopsida Ta.9069 35
(Zea mays)
Liliopsida Zm.10381 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4808 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04159 35
  • 55.37 (n)
  • 57.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC32H8.04c 35
  • 61.38 (n)
  • 64.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6957 36
  • 76 (a)
Species with no ortholog for FCF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FCF1 Gene

Gene Tree for FCF1 (if available)
Gene Tree for FCF1 (if available)

Paralogs for FCF1 Gene

(2) SIMAP similar genes for FCF1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FCF1: view

No data available for Paralogs for FCF1 Gene

Variants for FCF1 Gene

Sequence variations from dbSNP and Humsavar for FCF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7141254 -- 74,723,824(+) actct(G/T)tctca intron-variant
rs7144745 -- 74,736,768(+) ACTGA(C/T)TTACT downstream-variant-500B
rs7147721 -- 74,719,307(+) aaaaa(A/G)aagaa intron-variant
rs8007145 -- 74,719,045(+) GAATC(A/T)CTGGA intron-variant
rs3214408 -- 74,734,369(+) CATTT(-/A)AATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCF1 Gene

Variant ID Type Subtype PubMed ID
nsv832831 CNV Loss 17160897
nsv832832 CNV Gain+Loss 17160897

Variation tolerance for FCF1 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FCF1 Gene

Disorders for FCF1 Gene

Relevant External Links for FCF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FCF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCF1 Gene

Publications for FCF1 Gene

  1. Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. (PMID: 16762320) Rempola B. … Rytka J. (Biochem. Biophys. Res. Commun. 2006) 2 3 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for FCF1 Gene

Sources for FCF1 Gene