Aliases for FCF1 Gene
Aliases for FCF1 Gene
External Ids for FCF1 Gene
- HGNC: 20220
- Entrez Gene: 51077
- Ensembl: ENSG00000119616
- UniProtKB: Q9Y324
Previous HGNC Symbols for FCF1 Gene
- C14orf111
Previous GeneCards Identifiers for FCF1 Gene
- GC14P074250
- GC14P075179
Summaries for FCF1 Gene
GeneCards Summary for FCF1 Gene
FCF1 (FCF1 RRNA-Processing Protein) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.
UniProtKB/Swiss-Prot for FCF1 Gene
-
Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCF1 Gene
Genomics for FCF1 Gene
Regulatory Elements for FCF1 Gene
Regulatory Element Products
Genomic Location for FCF1 Gene
- Chromosome:
- 14
- Start:
- 74,713,117 bp from pter
- End:
- 74,738,620 bp from pter
- Size:
- 25,504 bases
- Orientation:
- Plus strand
Genomic View for FCF1 Gene
- Cytogenetic band:
-
- 14q24.3 by Ensembl
- 14q24.3 by Entrez Gene
- 14q24.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCF1 Gene
Proteins for FCF1 Gene
-
Protein details for FCF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y324-FCF1_HUMAN
- Recommended name:
- rRNA-processing protein FCF1 homolog
- Protein Accession:
- Q9Y324
- Q86TW8
- Q8TBL8
Protein attributes for FCF1 Gene
- Size:
- 198 amino acids
- Molecular mass:
- 23370 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAD62599.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FCF1 Gene
Post-translational modifications for FCF1 Gene
Other Protein References for FCF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FCF1
-
Abcam antibodies for FCF1
- Invitrogen Antibodies for FCF1
- Search GeneTex for Antibodies for FCF1
Protein Products
-
OriGene Purified Proteins for FCF1
- Search Origene for MassSpec and Protein Over-expression Lysates for FCF1
- Origene Custom Protein Services for FCF1
- antibodies-online Proteins for FCF1: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FCF1
Assay Products
No data available for DME Specific Peptides for FCF1 Gene
Domains & Families for FCF1 Gene
Protein Domains for FCF1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y324- Family:
-
- Belongs to the UTP23/FCF1 family. FCF1 subfamily.
No data available for Gene Families for FCF1 Gene
Function for FCF1 Gene
Molecular function for FCF1 Gene
- UniProtKB/Swiss-Prot Function:
- Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22658674 |
Phenotypes for FCF1 Gene
- GenomeRNAi human phenotypes for FCF1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Increased G1 DNA content
- G0/1 arrest
- Nucleoplasmic pre-40S maturation defects
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
- Decreased human parainfluenza virus type 3 (HPIV3) infection
- Nuclear 40S maturation defects
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FCF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCF1 gene
- Search ViGene Biosciences for FCF1
CRISPR Products
-
OriGene CRISPR knockouts for FCF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCF1
- GenScript: Design CRISPR guide RNA sequences for FCF1
miRNA for FCF1 Gene
- miRTarBase miRNAs that target FCF1
-
- hsa-mir-124-3p (MIRT023109)
- hsa-mir-15a-5p (MIRT071206)
- hsa-mir-16-5p (MIRT071207)
- hsa-mir-103a-3p (MIRT071208)
- hsa-mir-107 (MIRT071209)
- hsa-mir-15b-5p (MIRT071210)
- hsa-mir-195-5p (MIRT071211)
- hsa-mir-424-5p (MIRT071212)
- hsa-mir-497-5p (MIRT071213)
- hsa-mir-2115-3p (MIRT071216)
- hsa-mir-3609 (MIRT071218)
- hsa-mir-3613-3p (MIRT071219)
- hsa-mir-548ah-5p (MIRT071220)
- hsa-mir-4690-5p (MIRT071223)
- hsa-mir-4711-5p (MIRT071224)
- hsa-mir-6838-5p (MIRT071228)
- hsa-mir-4468 (MIRT544608)
- hsa-mir-3065-5p (MIRT544609)
- hsa-mir-3529-3p (MIRT544610)
- hsa-mir-8061 (MIRT619714)
- hsa-mir-4760-5p (MIRT619715)
- hsa-mir-6715b-3p (MIRT619716)
- hsa-mir-376a-5p (MIRT619717)
- hsa-mir-676-5p (MIRT619718)
- hsa-mir-6515-3p (MIRT619719)
- hsa-mir-4272 (MIRT619720)
- hsa-mir-6074 (MIRT619721)
miRNA Products
- Search ViGene Biosciences for FCF1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCF1
- Browse OriGene Inhibitory RNA Products For FCF1
-
ViGene Biosciences ready-to-package AAV shRNAs for FCF1 gene
Clone Products
- Sino Biological Human cDNA Clone for FCF1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FCF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCF1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCF1 Gene
Localization for FCF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCF1 Gene
- Nucleus, nucleolus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IEA,IBA | -- |
| GO:0032040 | small-subunit processome | IEA,IBA | -- |
Pathways & Interactions for FCF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 2 | Ribosome biogenesis in eukaryotes | ||
| 3 | Gene Expression |
.48
|
|
Pathways by source for FCF1 Gene
1 KEGG pathway for FCF1 Gene
Interacting Proteins for FCF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IEA | -- |
| GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0000480 | endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IEA | -- |
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0042254 | ribosome biogenesis | IEA | -- |
No data available for SIGNOR curated interactions for FCF1 Gene
Transcripts for FCF1 Gene
mRNA/cDNA for FCF1 Gene
- (5) REFSEQ mRNAs :
- (93) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FCF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCF1
- GenScript: Design CRISPR guide RNA sequences for FCF1
miRNA Products
- Search ViGene Biosciences for FCF1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCF1
- Browse OriGene Inhibitory RNA Products For FCF1
-
ViGene Biosciences ready-to-package AAV shRNAs for FCF1 gene
Clone Products
- Sino Biological Human cDNA Clone for FCF1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FCF1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FCF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FCF1 Gene:
FCF1SOURCE GeneReport for Unigene cluster for FCF1 Gene:
Hs.579828Primer Products
-
OriGene qPCR primer pairs for FCF1
-
OriGene qPCR primer pairs and template standards for FCF1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCF1 Gene
Orthologs for FCF1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCF1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| FCF1 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | FCF1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FCF1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fcf1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcf1 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FCF1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FCF1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FCF1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fcf1 34 |
|
||
| Str.1834 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.20881 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fcf1 34 |
|
||
| FCF1 35 |
|
OneToOne | |||
| wufc51c12 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Bka 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009504 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F30A10.9 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FCF1 34 35 37 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL102W 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A07018g 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G46230 34 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.13234 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.2007 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0158600 34 |
|
||
| Os.33206 34 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.9069 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.10381 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6957 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC32H8.04c 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04159 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4808 34 |
|
- Species where no ortholog for FCF1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for FCF1 Gene
(2) SIMAP similar genes for FCF1 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for FCF1 Gene
No data available for Paralogs for FCF1 Gene
Variants for FCF1 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000124777 | -- | 74,712,467(+) | GAAAA(A/G)AGCTA | intron-variant, upstream-variant-2KB | |
| rs1000189115 | -- | 74,718,623(+) | TGCAT(A/G)CTGCC | intron-variant | |
| rs1000231869 | -- | 74,718,909(+) | AATCC(C/T)AGTGC | intron-variant | |
| rs1000337272 | -- | 74,724,604(+) | TTTAG(G/T)GTAAC | intron-variant | |
| rs1000727506 | -- | 74,718,270(+) | TATAG(C/T)CCAAC | intron-variant |
Relevant External Links for FCF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCF1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCF1 Gene
Disorders for FCF1 Gene
Relevant External Links for FCF1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FCF1
No disorders were found for FCF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCF1 Gene
Publications for FCF1 Gene
- Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. (PMID: 16762320) Rempola B. … Rytka J. (Biochem. Biophys. Res. Commun. 2006) 2 3 64
- The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64
- Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for FCF1 Gene
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- OriGene Purified Proteins for FCF1
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- OriGene qPCR primer pairs and template standards for FCF1
- OriGene qPCR primer pairs for FCF1
- OriGene CRISPR knockouts for FCF1
- OriGene ORF clones in human for FCF1
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- GenScript: Design CRISPR guide RNA sequences for FCF1
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- Novus Biologicals Antibodies for FCF1
- Novus Biologicals proteins and lysates for FCF1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for FCF1 gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for FCF1
- VectorBuilder custom plasmid, inducible vectors for FCF1
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




