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FCER2 Gene

protein-coding   GIFtS: 65
GCID: GC19M007754

Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23)

(Previous names: Fc fragment of IgE, low affinity II, receptor for (CD23A))
(Previous symbols: CD23A, FCE2)
  See FCER2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23)1 2     CD23 Antigen2 3
FCE21 2 3 5     CD232 5
CD23A1 2 3     Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23A)1
CLEC4J2 3 5     C-Type Lectin Domain Family 4, Member J2
Immunoglobulin E-Binding Factor2 3     fc-epsilon-RII2
Lymphocyte IgE Receptor2 3     Low Affinity Immunoglobulin Epsilon Fc Receptor2
BLAST-22 3     Fc-epsilon-RII3
IGEBF2 3     C-Type Lectin Domain Family 4 Member J3

External Ids:    HGNC: 36121   Entrez Gene: 22082   Ensembl: ENSG000001049217   OMIM: 1514455   UniProtKB: P067343   

Export aliases for FCER2 gene to outside databases

Previous GC identifers: GC19M007712 GC19M007858 GC19M007648 GC19M007659 GC19M007423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCER2 Gene:
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has
essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also
exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for FCER2 Gene:
FCER2 (Fc fragment of IgE, low affinity II, receptor for (CD23)) is a protein-coding gene. Diseases associated with FCER2 include intrinsic asthma, and extrinsic allergic alveolitis. GO annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734
Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of
IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen)

Gene Wiki entry for FCER2 (CD23) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCER2 gene promoter:
         NF-1   RP58   AML1a   RelA   XBP-1   NF-kappaB   STAT3   ARP-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCER2 promoter sequence
   Search Chromatin IP Primers for FCER2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3

FCER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M007754:  view genomic region     (about GC identifiers)

Start:
7,753,643 bp from pter      End:
7,767,032 bp from pter
Size:
13,390 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734 (See protein sequence)
Recommended Name: Low affinity immunoglobulin epsilon Fc receptor  
Size: 321 amino acids; 36469 Da
Subunit: Homotrimer
Miscellaneous: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high
affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes
Sequence caution: Sequence=AAA52433.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for FCER2 (see all 21):
1HLI (3D)        1KJE (3D)        1T8C (3D)        1T8D (3D)        2H2R (3D)        2H2T (3D)    

Explore the universe of human proteins at neXtProt for FCER2: NX_P06734

Explore proteomics data for FCER2 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding1
  • Glycosylation2 at Asn63

  • See FCER2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193948.2  NP_001207429.1  NP_001993.2  

    ENSEMBL proteins: 
     ENSP00000264072   ENSP00000471974   ENSP00000472067   ENSP00000353178  
    Reactome Protein details: P06734

    FCER2 Human Recombinant Protein Products:

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    Novus Biologicals FCER2 Proteins
    Novus Biologicals FCER2 Lysates
    Sino Biological Recombinant Protein for FCER2
    Sino Biological Cell Lysate for FCER2
    ProSpec Recombinant Protein for FCER2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FCER2 

     
    antibodies-online proteins for FCER2 (24 products) 

     
    Search antibodies-online for peptides for FCER2

    FCER2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FCER2
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    antibodies-online antibodies for FCER2 (300 products) 

    FCER2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for FCER2 (CD23/Fc epsilon RII)         (see all)
    GenScript Custom Assay Services for FCER2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for FCER2: (see all 3
                        Human sCD23 Platinum ELISA 96 tests
    antibodies-online kits for FCER2 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P06734

    ProtoNet protein and cluster: P06734

    1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with FCER2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCER2_HUMAN, P06734
    Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of
    IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen)

         Genatlas biochemistry entry for FCER2:
    immunoglobulin E,low affinity Fc receptor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding TAS2529542
    GO:0019863IgE binding IEA--
    GO:0030246carbohydrate binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with FCER2           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fcer2a):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    Find genes that share phenotypes with FCER2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FCER2: Fcer2atm1Max Fcer2atm1Putt Fcer2atm1Kik

       genOway: Develop your customized and physiologically relevant rodent model for FCER2

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    Predesigned siRNA for gene silencing in human, mouse, rat FCER2

    Gene Editing
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    OriGene ORF clones in mouse, rat for FCER2
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    GenScript: all cDNA clones in your preferred vector: FCER2 (NM_002002)
    Sino Biological Human cDNA Clone for FCER2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER2

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    eBioscience FlowRNA Probe Sets ( VA6-13482) for FCER2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCER2_HUMAN, P06734: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted.
    Note=Also exists as a soluble excreted form, sCD23
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2529542
    GO:0009897external side of plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with FCER2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCER2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by NOTCH2
    Signaling by NOTCH20.67
    NOTCH2 intracellular domain regulates transcription0.00
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH0.64
    3Signaling by GPCR
    Signal Transduction0.58
    4GPCR Pathway
    NFAT in Immune Response0.58
    5PEDF Induced Signaling
    NFAT Signaling and Lymphocyte Interactions0.57


    Find genes that share SuperPaths with FCER2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FCER2
        IL-4 Pathway
    NFAT Signaling and Lymphocyte Interactions
    NFAT in Immune Response
    Phagocytosis of Microbes

    2 GeneGo (Thomson Reuters) Pathways for FCER2
        Immune response IL-4 signaling pathway
    Apoptosis and survival APRIL and BAFF signaling

    2 BioSystems Pathways for FCER2
        IL-3 Signaling Pathway
    IL4-mediated signaling events


    1 Reactome Pathway for FCER2
        NOTCH2 intracellular domain regulates transcription


    2 Kegg Pathways  (Kegg details for FCER2):
        Hematopoietic cell lineage
    Epstein-Barr virus infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FCER2: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FCER2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for FCER2 (P067343 ENSP000002640724) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062413, ENSP000003576564I2D: score=3 STRING: ENSP00000357656
    ITGAXP207023, ENSP000002682964I2D: score=2 STRING: ENSP00000268296
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    CR2P200233, ENSP000003560244I2D: score=3 STRING: ENSP00000356024
    STAT6P422263, ENSP000003001344I2D: score=1 STRING: ENSP00000300134
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin IEA--
    GO:0007219Notch signaling pathway TAS--
    GO:0051000positive regulation of nitric-oxide synthase activity IDA7544003
    GO:0051712positive regulation of killing of cells of other organism IDA7544003
    GO:0051770positive regulation of nitric-oxide synthase biosynthetic process IDA7544003

    Find genes that share ontologies with FCER2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCER2

    Selected Novoseek inferred chemical compound relationships for FCER2 gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    batimastat 44.8 12 9464810 (4), 9834082 (2), 9677315 (1)
    allergens 42.3 2 1477031 (1), 9036969 (1)
    cefadroxil 34.7 2 2143009 (1), 8309718 (1)
    fenoterol 34.3 1 7600375 (1)
    pdtc 26.5 1 12872985 (1)
    ionomycin 24.5 4 1709049 (1), 9162220 (1), 9174602 (1), 10363788 (1)
    nedocromil sodium 23.7 3 1334783 (3)
    tunicamycin 17.5 2 1386872 (1)
    neopterin 17.5 1 8104879 (1)
    genistein 16.8 6 9250823 (2), 8186375 (1), 11202232 (1), 8242759 (1)



    Find genes that share compounds with FCER2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCER2 gene (3 alternative transcripts): 
    NM_001207019.2  NM_001220500.1  NM_002002.4  

    Unigene Cluster for FCER2:

    Fc fragment of IgE, low affinity II, receptor for (CD23)
    Hs.465778  [show with all ESTs]
    Unigene Representative Sequence: BC014108
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597312 ENST00000346664(uc002mhn.3 uc002mhm.2 uc010xjt.2 uc010dvo.2)
    ENST00000597921 ENST00000598803 ENST00000597934 ENST00000593418 ENST00000360067(uc021unx.1)

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    Additional mRNA sequence: 

    AK223207.1 BC014108.2 BC062591.1 

    6 DOTS entries:

    DT.40217556  DT.100742549  DT.97781460  DT.95086505  DT.95162895  DT.95251779 

    Selected AceView cDNA sequences (see all 39):

    BI524037 BC064417 BC027879 BC014108 BC062591 NM_002002 BI767247 BV202551 
    BQ711965 AW448907 M14766 BI907608 BM008470 BM920436 M15059 AW401362 
    BP338917 BG755883 BI832853 BF891578 X04772 AI936513 BQ712620 AI523923 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FCER2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                 -     -     -                                                   
    SP2:                    -                 -     -     -                                                   
    SP3:                                      -     -     -                       -                           
    SP4:                    -                                                                                 
    SP5:                    -                                                                                 


    ECgene alternative splicing isoforms for FCER2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATACAGCCA
    FCER2 Expression
    About this image


    FCER2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    FCER2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCER2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465778
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FCER2: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FCER2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcer2a1 , 5 Fc receptor, IgE, low affinity II, alpha polypeptide1, 5 70.67(n)1
    58.12(a)1
      8 (1.92 cM)5
    141281  NM_013517.41  NP_038545.11 
     36817375 
    chicken
    (Gallus gallus)
    Aves LOC1008587511 low affinity immunoglobulin epsilon Fc receptor-like 50.53(n)
    36.2(a)
      100858751  XM_003643371.2  XP_003643419.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    1 → many
    2(102766152-102779611)


    ENSEMBL Gene Tree for FCER2 (if available)
    TreeFam Gene Tree for FCER2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCER2 gene
    CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    Selected SIMAP similar genes for FCER2 using alignment to 5 protein entries:     FCER2_HUMAN (see all proteins) (see all similar genes):
    CLEC2D    KLRC4-KLRK1    KLRD1    KLRK1    ASGR2    CLEC10A
    CLEC17A    HBXBP    OLR1    KLRC1    KLRC2    CLEC4M
    CLEC4C    CD69    ASGR1    KLRC3    MRC2    CD209

    Find genes that share paralogs with FCER2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCER2 (see all 651)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440693911,2
    C--7692687(+) GATCCA/G/TCCTGC 3 -- ds50010--------
    rs567050091,2
    C,F--7692695(+) TGCCTC/TGGCCT 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1409594441,2
    C--7692759(+) ATTTTG/TAATAG 3 -- ds50010--------
    rs1895116951,2
    --7692767(+) TAGAGA/CCGGGG 3 -- ds50010--------
    rs1922479471,2
    --7692768(+) AGAGAC/TGGGGT 3 -- ds50010--------
    rs583424101,2
    C,F--7692781(+) TGCCAC/TGTTGG 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs577208451,2
    C--7692787(+) GTTGGG/CCAGGC 3 -- ds50011Minor allele frequency- C:0.50WA 2
    rs576381761,2
    C,F--7692835(+) TTGACT/CTCCCA 3 -- ds50014Minor allele frequency- C:0.08WA NA EA 360
    rs1489114001,2
    --7692868(+) GGCCAC/GCACAC 3 -- ds50010--------
    rs283958871,2
    C,F,H--7692917(+) CTCAGA/C/G/
            
    CATCA
    3 -- ds50013NS CSA 265

    HapMap Linkage Disequilibrium report for FCER2 (7753643 - 7767032 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCER2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv543e201CNV Deletion23290073
    esv2718104CNV Deletion23290073
    esv2718099CNV Deletion23290073
    dgv542e201CNV Deletion23290073
    esv2405737CNV Deletion18987734
    nsv910970CNV Loss21882294
    esv8263CNV Loss19470904
    nsv833731CNV Loss17160897
    esv2751809CNV Gain17911159
    esv26340CNV Gain19812545

    Human Gene Mutation Database (HGMD): FCER2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCER2
    DNA2.0 Custom Variant and Variant Library Synthesis for FCER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151445    OMIM disorders: --

    Selected diseases for FCER2 (see all 22):    
    About MalaCards
    intrinsic asthma    extrinsic allergic alveolitis    chronic conjunctivitis    dendritic cell sarcoma
    follicular dendritic cell tumor    cardiac tamponade    follicular dendritic cell sarcoma    splenic marginal zone lymphoma
    gastric lymphoma    cutaneous leishmaniasis    systemic mastocytosis    conjunctivitis
    kawasaki disease    primary effusion lymphoma    severe acute respiratory syndrome    bullous pemphigoid
    rhinitis    atopy    chronic lymphocytic leukemia    b-cell chronic lymphocytic leukemia

    4 diseases from the University of Copenhagen DISEASES database for FCER2:
    Hypersensitivity reaction type I disease     Atopic dermatitis     Asthma     Allergic rhinitis

    Find genes that share disorders with FCER2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FCER2 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphocytic leukemia chronic b-cell 72.4 11 10052715 (2), 15621797 (2), 7517747 (1), 1717071 (1) (see all 9)
    leukemia lymphocytic chronic 67.5 17 11064465 (3), 2137545 (2), 8332446 (2), 1532590 (2) (see all 10)
    lymphoma small lymphocytic 66.8 3 8058704 (1), 16540722 (1), 10478136 (1)
    leukaemia lymphocytic 65.3 17 9508354 (2), 10233382 (2), 7873388 (2), 10713330 (1) (see all 13)
    dermatitis atopic 64.6 24 1531123 (4), 9543080 (3), 8453305 (2), 8785171 (2) (see all 15)
    leukemia eosinophilic 61.9 2 8589271 (1), 9620595 (1)
    asthma allergic 56.3 10 9450145 (3), 1334783 (1), 7653734 (1), 1401914 (1) (see all 7)
    chronic conjunctivitis 55.2 2 9191610 (1), 9154386 (1)
    burkitt lymphoma 54.8 2 9036969 (1), 1354347 (1)
    lymphoma 52.3 22 11211615 (3), 10478136 (3), 8058704 (2), 9508354 (2) (see all 14)

    Genetic Association Database (GAD): FCER2
    Human Genome Epidemiology (HuGE) Navigator: FCER2 (17 documents)

    Export disorders for FCER2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCER2 gene, integrated from 10 sources (see all 528):
    (articles sorted by number of sources associating them with FCER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure of human CD23 and its interactions with IgE and CD21. (PubMed id 16172256)1, 2, 9 Hibbert R.G.... McDonnell J.M. (J. Exp. Med. 2005)
    2. Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding. (PubMed id 16765898)1, 2, 9 Wurzburg B.A.... Jardetzky T.S. (Structure 2006)
    3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    8. Predictors of poor response during asthma therapy differ with definition of outcome. (PubMed id 19663668)1, 4 Rogers A.J....Weiss S.T. (Pharmacogenomics 2009)
    9. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PubMed id 18568448)1, 4 Mizuta I....Toda T. (Hum. Genet. 2008)
    10. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2208 HGNC: 3612 AceView: FCER2 Ensembl:ENSG00000104921 euGenes: HUgn2208
    ECgene: FCER2 Kegg: 2208 H-InvDB: FCER2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FCER2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FCER2 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_221

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCER2 gene:
    Search GeneIP for patents involving FCER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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