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FCER2 Gene(Protein Coding)

Fc Fragment Of IgE Receptor II

GCID:
GC19M007689
GIFtS:
66
Genes Participants
UDN Logo

Aliases for FCER2 Gene

Aliases for FCER2 Gene

  • Fc Fragment Of IgE Receptor II 2 3 5
  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23) 2 3
  • Immunoglobulin E-Binding Factor 3 4
  • Lymphocyte IgE Receptor 3 4
  • Fc Epsilon Receptor II 2 3
  • Fc-Epsilon-RII 3 4
  • CD23 Antigen 3 4
  • BLAST-2 3 4
  • CLEC4J 3 4
  • CD23A 3 4
  • IGEBF 3 4
  • FCE2 3 4
  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23A) 2
  • Low Affinity Immunoglobulin Epsilon Fc Receptor 3
  • C-Type Lectin Domain Family 4, Member J 3
  • C-Type Lectin Domain Family 4 Member J 4
  • Immunoglobulin Epsilon-Chain 3
  • CD23 3

External Ids for FCER2 Gene

Previous HGNC Symbols for FCER2 Gene

  • CD23A
  • FCE2

Previous GeneCards Identifiers for FCER2 Gene

  • GC19M007712
  • GC19M007858
  • GC19M007648
  • GC19M007659
  • GC19M007423
  • GC19M007754

Summaries for FCER2 Gene

Entrez Gene Summary for FCER2 Gene

  • The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for FCER2 Gene

FCER2 (Fc Fragment Of IgE Receptor II) is a Protein Coding gene. Diseases associated with FCER2 include Chronic Conjunctivitis and Persistent Polyclonal B-Cell Lymphocytosis. Among its related pathways are PEDF Induced Signaling and Innate Immune System. GO annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is CLEC4G.

UniProtKB/Swiss-Prot for FCER2 Gene

  • Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Gene Wiki entry for FCER2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER2 Gene

Genomics for FCER2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FCER2 Gene

Enhancers for FCER2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G007700 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -2.2 -2178 7.0 HDGF PKNOX1 YBX1 ELK1 ZNF143 ZNF207 JUNB TBX21 ZNF610 NBN STXBP2 FCER2 PEX11G CD209 CLEC4G RPL21P129 MCEMP1 MCOLN1 PNPLA6 RAB11B-AS1
GH19G007698 1.4 Ensembl ENCODE dbSUPER 17.6 +2.7 2709 2.0 HDAC1 HDGF TBP CBX3 TBL1XR1 NFIB ZNF195 ZEB1 TCF12 GATA2 ELAVL1 FCER2 HNRNPM XAB2 GC19P007703
GH19G007690 1.5 FANTOM5 ENCODE dbSUPER 14.8 +10.4 10381 2.8 HDGF PKNOX1 WRNIP1 BMI1 YBX1 ZBTB7B CBX5 ZSCAN5C ZNF143 ZNF207 FCER2 ELAVL1 HNRNPM ARHGEF18 MAP2K7 EVI5L FBN3 GC19P007703 TRAPPC5
GH19G007772 1.1 Ensembl ENCODE 12.3 -70.7 -70691 0.8 PKNOX1 BMI1 ZSCAN5C RELB IKZF2 CREM CBFB JUNB GATAD2B ELF1 RPL21P129 CD209 FCER2 CLEC4G CLEC4GP1 LOC105372263 GC19P007785
GH19G007344 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.3 +354.4 354412 7.0 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B DMAP1 YBX1 ZNF48 SLC30A9 FCER2 ZNF557 ARHGEF18 GC19P007345
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCER2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FCER2 gene promoter:

Genomic Location for FCER2 Gene

Chromosome:
19
Start:
7,688,757 bp from pter
End:
7,702,310 bp from pter
Size:
13,554 bases
Orientation:
Minus strand

Genomic View for FCER2 Gene

Genes around FCER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCER2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FCER2 Gene

Proteins for FCER2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FCER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06734-FCER2_HUMAN
    Recommended name:
    Low affinity immunoglobulin epsilon Fc receptor
    Protein Accession:
    P06734

    Protein attributes for FCER2 Gene

    Size:
    321 amino acids
    Molecular mass:
    36469 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.
    SequenceCaution:
    • Sequence=AAA52433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCER2 Gene

neXtProt entry for FCER2 Gene

Protein Expression for FCER2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FCER2 Gene

Other Protein References for FCER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FCER2 (CD23/Fc epsilon RII)

No data available for DME Specific Peptides for FCER2 Gene

Domains & Families for FCER2 Gene

Gene Families for FCER2 Gene

HGNC:

Protein Domains for FCER2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FCER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCER2: view

No data available for UniProtKB/Swiss-Prot for FCER2 Gene

Function for FCER2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FCER2 Gene

GENATLAS Biochemistry:
immunoglobulin E,low affinity Fc receptor
UniProtKB/Swiss-Prot Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Gene Ontology (GO) - Molecular Function for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 2529542
GO:0005515 protein binding IPI 25416956
GO:0019863 IgE binding IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FCER2: view
genes like me logo Genes that share phenotypes with FCER2: view

Animal Models for FCER2 Gene

MGI Knock Outs for FCER2:

Animal Model Products

CRISPR Products

miRNA for FCER2 Gene

miRTarBase miRNAs that target FCER2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCER2 Gene

Localization for FCER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER2 Gene

Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCER2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2529542
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FCER2: view

Pathways & Interactions for FCER2 Gene

genes like me logo Genes that share pathways with FCER2: view

Gene Ontology (GO) - Biological Process for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0007219 Notch signaling pathway TAS --
GO:0051000 positive regulation of nitric-oxide synthase activity IDA 7544003
GO:0051712 positive regulation of killing of cells of other organism IDA 7544003
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IDA 7544003
genes like me logo Genes that share ontologies with FCER2: view

No data available for SIGNOR curated interactions for FCER2 Gene

Drugs & Compounds for FCER2 Gene

Products:

  1. Drug

(29) Drugs for FCER2 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LUMILIXIMAB Pharma 0

(19) Additional Compounds for FCER2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCER2: view

Transcripts for FCER2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FCER2 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCER2 Gene

Fc fragment of IgE, low affinity II, receptor for (CD23):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCER2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for FCER2 Gene

GeneLoc Exon Structure for
FCER2
ECgene alternative splicing isoforms for
FCER2

Expression for FCER2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCER2 Gene

mRNA expression in normal human tissues for FCER2 Gene
mRNA expression by BioGPS for FCER2 GenemRNA expression by GTEx for FCER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER2 Gene

This gene is overexpressed in Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for FCER2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER2 Gene



Protein tissue co-expression partners for FCER2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCER2 Gene:

FCER2

SOURCE GeneReport for Unigene cluster for FCER2 Gene:

Hs.465778

Evidence on tissue expression from TISSUES for FCER2 Gene

  • Blood(4.6)
  • Lymph node(2.4)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with FCER2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER2 Gene

Orthologs for FCER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FCER2 34 35
  • 85.76 (n)
dog
(Canis familiaris)
 Mammalia FCER2 34 35
  • 78.36 (n)
cow
(Bos Taurus)
 Mammalia FCER2 34 35
  • 75.69 (n)
mouse
(Mus musculus)
 Mammalia Fcer2a 34 16 35
  • 70.67 (n)
rat
(Rattus norvegicus)
 Mammalia Fcer2 34
  • 70.13 (n)
oppossum
(Monodelphis domestica)
 Mammalia FCER2 35
  • 37 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LOC100858751 34
  • 50.53 (n)
FCER2 35
  • 28 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 30 (a)
 OneToMany
Species where no ortholog for FCER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER2 Gene

ENSEMBL:
Gene Tree for FCER2 (if available)
TreeFam:
Gene Tree for FCER2 (if available)

Paralogs for FCER2 Gene

Variants for FCER2 Gene

Sequence variations from dbSNP and Humsavar for FCER2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000025918 -- 7,700,671(+) CACCA(A/T)GACCA intron-variant, upstream-variant-2KB
rs1000285709 -- 7,703,464(+) GTGTG(C/T)CCCCA intron-variant, upstream-variant-2KB
rs1000451044 -- 7,703,889(+) CCTGG(A/C)TTGGC intron-variant, upstream-variant-2KB
rs1000481356 -- 7,698,611(+) ATGGG(A/G)GGCAG intron-variant
rs1000558528 -- 7,696,659(+) GCACA(C/G)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCER2 Gene

Variant ID Type Subtype PubMed ID
dgv501e201 CNV deletion 23290073
dgv502e201 CNV deletion 23290073
dgv6248n54 CNV loss 21841781
dgv6249n54 CNV loss 21841781
dgv6250n54 CNV loss 21841781
dgv6251n54 CNV loss 21841781
esv2405737 CNV deletion 18987734
esv26340 CNV gain 19812545
esv2718099 CNV deletion 23290073
esv2718104 CNV deletion 23290073
esv2751809 CNV gain 17911159
esv3388356 CNV duplication 20981092
esv8263 CNV loss 19470904
esv8285 CNV gain 19470904
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv1120353 CNV tandem duplication 24896259
nsv1125205 CNV insertion 24896259
nsv578518 CNV loss 21841781
nsv578522 CNV loss 21841781
nsv578535 CNV loss 21841781
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for FCER2 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.75; 86.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCER2 Gene

Human Gene Mutation Database (HGMD)
FCER2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER2 Gene

Disorders for FCER2 Gene

MalaCards: The human disease database

(21) MalaCards diseases for FCER2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic conjunctivitis
  • chronic conjunctivitis nos
persistent polyclonal b-cell lymphocytosis
  • ppbl
follicular dendritic cell sarcoma
  • follicular dendritic cell tumour
chronic lymphocytic leukemia
  • cll
reticulum cell sarcoma
  • interdigitating dendritic cell sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search FCER2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCER2

Genetic Association Database (GAD)
FCER2
Human Genome Epidemiology (HuGE) Navigator
FCER2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCER2
genes like me logo Genes that share disorders with FCER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER2 Gene

Publications for FCER2 Gene

  1. Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding. (PMID: 16765898) Wurzburg B.A. … Jardetzky T.S. (Structure 2006) 3 4 22 64
  2. The structure of human CD23 and its interactions with IgE and CD21. (PMID: 16172256) Hibbert R.G. … McDonnell J.M. (J. Exp. Med. 2005) 3 4 22 64
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64

Products for FCER2 Gene

  • Addgene plasmids for FCER2

Sources for FCER2 Gene

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