Aliases for FCER2 Gene
External Ids for FCER2 Gene
Previous HGNC Symbols for FCER2 Gene
Previous GeneCards Identifiers for FCER2 Gene
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for FCER2 Gene
FCER2 (Fc Fragment Of IgE Receptor II) is a Protein Coding gene. Diseases associated with FCER2 include Chronic Conjunctivitis and Chronic Lymphocytic Leukemia. Among its related pathways are IL4-mediated signaling events and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is CLEC6A.
UniProtKB/Swiss-Prot for FCER2 Gene
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).