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Aliases for FCER2 Gene

Aliases for FCER2 Gene

  • Fc Fragment Of IgE Receptor II 2 3
  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23) 2 3 5
  • Immunoglobulin E-Binding Factor 3 4
  • Lymphocyte IgE Receptor 3 4
  • Fc Epsilon Receptor II 2 3
  • Fc-Epsilon-RII 3 4
  • CD23 Antigen 3 4
  • BLAST-2 3 4
  • CLEC4J 3 4
  • CD23A 3 4
  • IGEBF 3 4
  • FCE2 3 4
  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23A) 2
  • C-Type Lectin Domain Family 4, Member J 3
  • C-Type Lectin Domain Family 4 Member J 4
  • Immunoglobulin Epsilon-Chain 3
  • CD23 3

External Ids for FCER2 Gene

Previous HGNC Symbols for FCER2 Gene

  • CD23A
  • FCE2

Previous GeneCards Identifiers for FCER2 Gene

  • GC19M007712
  • GC19M007858
  • GC19M007648
  • GC19M007659
  • GC19M007423
  • GC19M007754

Summaries for FCER2 Gene

Entrez Gene Summary for FCER2 Gene

  • The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for FCER2 Gene

FCER2 (Fc Fragment Of IgE Receptor II) is a Protein Coding gene. Diseases associated with FCER2 include leukemia, chronic lymphocytic 2 and cutaneous leishmaniasis. Among its related pathways are Signaling by GPCR and Signaling by NOTCH1. GO annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is CLEC6A.

UniProtKB/Swiss-Prot for FCER2 Gene

  • Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Gene Wiki entry for FCER2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER2 Gene

Genomics for FCER2 Gene

Regulatory Elements for FCER2 Gene

Promoters for FCER2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FCER2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FCER2 Gene

Chromosome:
19
Start:
7,688,757 bp from pter
End:
7,702,310 bp from pter
Size:
13,554 bases
Orientation:
Minus strand

Genomic View for FCER2 Gene

Genes around FCER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER2 Gene

Proteins for FCER2 Gene

  • Protein details for FCER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06734-FCER2_HUMAN
    Recommended name:
    Low affinity immunoglobulin epsilon Fc receptor
    Protein Accession:
    P06734

    Protein attributes for FCER2 Gene

    Size:
    321 amino acids
    Molecular mass:
    36469 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.
    SequenceCaution:
    • Sequence=AAA52433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCER2 Gene

neXtProt entry for FCER2 Gene

Proteomics data for FCER2 Gene at MOPED

Post-translational modifications for FCER2 Gene

Other Protein References for FCER2 Gene

Antibody Products

  • R&D Systems Antibodies for FCER2 (CD23/Fc epsilon RII)

Protein Products

No data available for DME Specific Peptides for FCER2 Gene

Domains & Families for FCER2 Gene

Gene Families for FCER2 Gene

Suggested Antigen Peptide Sequences for FCER2 Gene

Graphical View of Domain Structure for InterPro Entry

P06734

UniProtKB/Swiss-Prot:

FCER2_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with FCER2: view

Function for FCER2 Gene

Molecular function for FCER2 Gene

GENATLAS Biochemistry:
immunoglobulin E,low affinity Fc receptor
UniProtKB/Swiss-Prot Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
genes like me logo Genes that share phenotypes with FCER2: view

Animal Models for FCER2 Gene

MGI Knock Outs for FCER2:

Animal Model Products

CRISPR Products

miRNA for FCER2 Gene

miRTarBase miRNAs that target FCER2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FCER2
  • R&D Systems cDNA Clones for FCER2 (CD23/Fc epsilon RII)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCER2 Gene

Localization for FCER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER2 Gene

Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCER2 Gene COMPARTMENTS Subcellular localization image for FCER2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FCER2: view

Pathways & Interactions for FCER2 Gene

genes like me logo Genes that share pathways with FCER2: view

Gene Ontology (GO) - Biological Process for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IDA 7544003
genes like me logo Genes that share ontologies with FCER2: view

No data available for SIGNOR curated interactions for FCER2 Gene

Drugs & Compounds for FCER2 Gene

(27) Drugs for FCER2 Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LUMILIXIMAB Pharma 0

(21) Additional Compounds for FCER2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCER2: view

Transcripts for FCER2 Gene

Unigene Clusters for FCER2 Gene

Fc fragment of IgE, low affinity II, receptor for (CD23):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FCER2
  • R&D Systems cDNA Clones for FCER2 (CD23/Fc epsilon RII)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCER2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for FCER2 Gene

GeneLoc Exon Structure for
FCER2
ECgene alternative splicing isoforms for
FCER2

Expression for FCER2 Gene

mRNA expression in normal human tissues for FCER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER2 Gene

This gene is overexpressed in Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for FCER2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER2 Gene



SOURCE GeneReport for Unigene cluster for FCER2 Gene Hs.465778

genes like me logo Genes that share expression patterns with FCER2: view

Protein tissue co-expression partners for FCER2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FCER2 Gene

Orthologs for FCER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCER2 36
  • 96 (a)
OneToOne
FCER2 35
  • 85.76 (n)
  • 80.91 (a)
cow
(Bos Taurus)
Mammalia FCER2 36
  • 58 (a)
OneToOne
FCER2 35
  • 75.69 (n)
  • 65.28 (a)
dog
(Canis familiaris)
Mammalia FCER2 35
  • 78.36 (n)
  • 65.62 (a)
FCER2 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcer2a 16
Fcer2a 36
  • 54 (a)
OneToOne
Fcer2a 35
  • 70.67 (n)
  • 58.12 (a)
oppossum
(Monodelphis domestica)
Mammalia FCER2 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcer2 35
  • 70.13 (n)
  • 58.44 (a)
chicken
(Gallus gallus)
Aves LOC100858751 35
  • 50.53 (n)
  • 36.2 (a)
FCER2 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for FCER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER2 Gene

ENSEMBL:
Gene Tree for FCER2 (if available)
TreeFam:
Gene Tree for FCER2 (if available)

Paralogs for FCER2 Gene

genes like me logo Genes that share paralogs with FCER2: view

Variants for FCER2 Gene

Sequence variations from dbSNP and Humsavar for FCER2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2228137 - 7,698,362(-) CTGCC(C/G/T)GGAAC reference, missense
rs8102872 - 7,689,308(+) CCAGC(C/T)GGTCG reference, missense
VAR_069800 -
rs889182 -- 7,700,380(+) TCTTC(A/G)GATTC intron-variant, upstream-variant-2KB
rs2277989 -- 7,696,926(+) GAGTC(A/C/G/T)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCER2 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv910970 CNV Loss 21882294
nsv833731 CNV Loss 17160897
nsv833732 CNV Gain 17160897
esv2718099 CNV Deletion 23290073
esv2405737 CNV Deletion 18987734
esv26340 CNV Gain 19812545
esv8285 CNV Gain 19470904
dgv542e201 CNV Deletion 23290073
dgv543e201 CNV Deletion 23290073
esv8263 CNV Loss 19470904
esv2718104 CNV Deletion 23290073

Variation tolerance for FCER2 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.75; 86.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCER2 Gene

HapMap Linkage Disequilibrium report
FCER2
Human Gene Mutation Database (HGMD)
FCER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER2 Gene

Disorders for FCER2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FCER2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic 2
  • leukemia, chronic lymphocytic, susceptibility to, 2
cutaneous leishmaniasis
  • asian desert cutaneous leishmaniasis
food allergy
  • food hypersensitivity
scabies
  • infestation by sarcoptes scabiei
atopy
  • atopic hypersensitivity
- elite association - COSMIC cancer census association via MalaCards
Search FCER2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCER2

Genetic Association Database (GAD)
FCER2
Human Genome Epidemiology (HuGE) Navigator
FCER2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCER2
genes like me logo Genes that share disorders with FCER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER2 Gene

Publications for FCER2 Gene

  1. The structure of human CD23 and its interactions with IgE and CD21. (PMID: 16172256) Hibbert R.G. … McDonnell J.M. (J. Exp. Med. 2005) 3 4 23 67
  2. Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells. (PMID: 17576766) McCloskey N. … Gould H.J. (J. Biol. Chem. 2007) 3 23
  3. Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding. (PMID: 16765898) Wurzburg B.A. … Jardetzky T.S. (Structure 2006) 3 23
  4. CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK. (PMID: 16899715) Tu Y. … Perdue M.H. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 23
  5. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. (PMID: 15795251) Chang H. … Jung J.U. (J. Virol. 2005) 3 23

Products for FCER2 Gene

Sources for FCER2 Gene

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