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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FCER2 Gene

protein-coding GIFtS: 64
GCID: GC19M007754

Fc fragment of IgE, low affinity II, receptor for (CD23)

(Previous names: Fc fragment of IgE, low affinity II, receptor for (CD23A)...)
(Previous symbols: CD23A, FCE2)

Explore 74 diseases affiliated with
FCER2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23)¹ ²		IGEBF² ³
CLEC4J¹ ² ³ ⁵		CD23 Antigen² ³
FCE2¹ ² ³ ⁵		Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23A)¹
CD23A¹ ² ³		C-Type Lectin Domain Family 4, Member J²
CD23¹ ² ⁵		Fc-Epsilon-RII¹
Immunoglobulin E-Binding Factor² ³		Low Affinity Immunoglobulin Epsilon Fc Receptor²
Lymphocyte IgE Receptor² ³		Fc-Epsilon-RII¹
BLAST-2² ³		C-Type Lectin Domain Family 4 Member J³

External Ids:	HGNC: 3612¹	Entrez Gene: 2208²	Ensembl: ENSG00000104921⁷	OMIM: 151445⁵	UniProtKB: P06734³

Export aliases for FCER2 gene to outside databases

Previous GC identifers: GC19M007712 GC19M007858 GC19M007648 GC19M007659 GC19M007423

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCER2:

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential

roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a

soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants

encoding different isoforms have been described for this gene.(provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734

Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE

production and in the differentiation of B-cells (it is a B-cell-specific antigen)

Gene Wiki entry for FCER2 (CD23)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_077812.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FCER2 gene promoter:
NF-1 RP58 AML1a RelA XBP-1 NF-kappaB STAT3 ARP-1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCER2 promoter sequence

Search SABiosciences Chromatin IP Primers for FCER2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCER2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3

FCER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M007754: view genomic region (about GC identifiers)

Start:	7,753,643 bp from pter	End:	7,767,032 bp from pter
Size:	13,390 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734 (See protein sequence)

Recommended Name: Low affinity immunoglobulin epsilon Fc receptor

Size: 321 amino acids; 36469 Da

Subunit: Homotrimer

Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted.

Note=Also exists as a soluble excreted form, sCD23

Miscellaneous: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity

receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes

Sequence caution: Sequence=AAA52433.1; Type=Erroneous gene model prediction;

6/7 PDB 3D structures from and Proteopedia for FCER2 (see all 7):

1HLI (3D)

1KJE (3D)

1T8C (3D)

1T8D (3D)

2H2R (3D)

2H2T (3D)

Explore the universe of human proteins at neXtProt for FCER2: NX_P06734

Post-translational modifications:

N- and O-glycosylated¹

The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding¹

View neXtProt modification sites for NX_P06734

FCER2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001193948.2 NP_001207429.1 NP_001993.2

ENSEMBL proteins:

ENSP00000264072 ENSP00000353178

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for FCER2 (CD23/Fc epsilon RII)
	Enzo Life Sciences proteins for FCER2
	OriGene Purified Protein: FCER2 OriGene Protein Over-expression Lysate: FCER2 OriGene Custom Protein Services for FCER2
	GenScript Custom Purified and Recombinant Proteins Services for FCER2
	Novus Biologicals FCER2 Proteins Novus Biologicals FCER2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FCER2
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005887	integral to plasma membrane	TAS	2529542
GO:0009897	external side of plasma membrane	IEA	--

FCER2 for ontologies About GeneDecksing

FCER2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FCER2
	R&D Systems Antibodies for FCER2 (CD23/Fc epsilon RII)
	OriGene Antibodies (see all 10): FCER2 OriGene Custom Antibody Services for FCER2
	GenScript Custom Superior Antibodies Services for FCER2
	Novus Biologicals FCER2 Antibodies
	Abcam antibodies for FCER2
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for FCER2

Assay Products for FCER2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FCER2 (CD23/Fc epsilon RII) (see all)
	GenScript Custom Assay Services for FCER2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FCER2 for domains About GeneDecksing

4 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry P06734

ProtoNet protein and cluster: P06734

1 Blocks protein family: IPB002353 Type II antifreeze protein signature

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734

Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE

production and in the differentiation of B-cells (it is a B-cell-specific antigen)

Genatlas biochemistry entry for FCER2:

immunoglobulin E,low affinity Fc receptor

miRNA Products:		OriGene 3'-UTR Clone: FCER2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCER2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FCER2
		SwitchGear 3'UTR luciferase reporter plasmid: FCER2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCER2 (see all 4) OriGene shRNA RFP: FCER2 OriGene siRNA: FCER2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCER2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FCER2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCER2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCER2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FCER2 (NM_002002)
		Sino Biological Human cDNA Clone for FCER2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCER2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FCER2
		Search LifeMap BioReagents cell lines for FCER2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005178	integrin binding	TAS	2529542
GO:0019863	IgE binding	IEA	--
GO:0030246	carbohydrate binding	IEA	--
GO:0046872	metal ion binding	IEA	--

FCER2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for FCER2: Fcer2a^tm1Max Fcer2a^tm1Putt Fcer2a^tm1Kik
     4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fcer2a):

cellular

digestive/alimentary

hematopoietic system

immune system

FCER2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-4 signaling pathway

Immune response_IL-4 signaling pathway

1.00

Immune response IL-4 signaling pathway

0.98

BAFF in B-Cell Signaling

Apoptosis and survival_APRIL and BAFF signaling

0.39

Apoptosis and survival APRIL and BAFF signaling

0.39

Phagocytosis of Microbes

Phagocytosis of Microbes

1.00

IL-3 Signaling Pathway

IL-3 Signaling Pathway

1.00

IL4-mediated signaling events

IL4-mediated signaling events

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for FCER2

	Immune response IL-4 signaling pathway
	Apoptosis and survival APRIL and BAFF signaling
	Metalloproteases in connective tissue degradation

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FCER2

	IL-4 Pathway
	NFAT Signaling and Lymphocyte Interactions
	NFAT in Immune Response
	Phagocytosis of Microbes

2 GeneGo (Thomson Reuters) Pathways for FCER2

	Immune response IL-4 signaling pathway
	Apoptosis and survival APRIL and BAFF signaling

2 BioSystems Pathways for FCER2

	IL-3 Signaling Pathway
	IL4-mediated signaling events

1 Kegg Pathway (Kegg details for FCER2):

Hematopoietic cell lineage

FCER2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FCER2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for FCER2 (P06734³ ENSP00000264072⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FYN	P06241³, ENSP00000357656⁴	I2D: score=3 STRING: ENSP00000357656
ITGAX	P20702³, ENSP00000268296⁴	I2D: score=2 STRING: ENSP00000268296
ITGB2	P05107³, ENSP00000303242⁴	I2D: score=2 STRING: ENSP00000303242
CR2	P20023³, ENSP00000356024⁴	I2D: score=3 STRING: ENSP00000356024
STAT6	P42226³, ENSP00000300134⁴	I2D: score=1 STRING: ENSP00000300134

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	IEA	--
GO:0051000	positive regulation of nitric-oxide synthase activity	IDA	7544003
GO:0051712	positive regulation of killing of cells of other organism	IDA	7544003
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IDA	7544003

FCER2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FCER2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FCER2
10/47 Novoseek chemical compound relationships for FCER2 gene (see all 47) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
batimastat	44.8	12	9464810 (4), 9834082 (2), 9677315 (1)
allergens	42.3	2	1477031 (1), 9036969 (1)
cefadroxil	34.7	2	2143009 (1), 8309718 (1)
fenoterol	34.3	1	7600375 (1)
pdtc	26.5	1	12872985 (1)
ionomycin	24.5	4	1709049 (1), 9162220 (1), 9174602 (1), 10363788 (1)
nedocromil sodium	23.7	3	1334783 (3)
tunicamycin	17.5	2	1386872 (1)
neopterin	17.5	1	8104879 (1)
genistein	16.8	6	9250823 (2), 8186375 (1), 11202232 (1), 8242759 (1)

Search CenterWatch for drugs/clinical trials and news about FCER2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FCER2 gene (3 alternative transcripts):

NM_001207019.2 NM_001220500.1 NM_002002.4

Unigene Cluster for FCER2:

Fc fragment of IgE, low affinity II, receptor for (CD23)

Hs.465778 [show with all ESTs]

Unigene Representative Sequence: BC014108

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000346664(uc002mhn.3 uc002mhm.2 uc010xjt.2 uc010dvo.2)

ENST00000360067(uc021unx.1)

miRNA Products:		OriGene 3'-UTR Clone: FCER2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCER2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FCER2
		SwitchGear 3'UTR luciferase reporter plasmid: FCER2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCER2 (see all 4) OriGene shRNA RFP: FCER2 OriGene siRNA: FCER2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCER2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCER2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCER2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FCER2 (NM_002002)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCER2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCER2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FCER2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCER2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCER2

Additional cDNA sequence:

AK223207.1 BC014108.2 BC062591.1

6 DOTS entries:

DT.40217556 DT.100742549 DT.97781460 DT.95086505 DT.95162895 DT.95251779

24/39 AceView cDNA sequences (see all 39):

BC062591 BC014108 NM_002002 BC064417 BI524037 BC027879 BI832853 M14766

M15059 BQ712620 BI767247 BQ711965 X04772 BV202551 BM920436 BI907608

AW401362 AW448907 BF891578 BP338917 BG755883 AI936513 BM008470 AI494545

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FCER2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12
SP1:							-						-		-		-
SP2:							-						-		-		-
SP3:													-		-		-								-
SP4:							-
SP5:							-

ECgene alternative splicing isoforms for FCER2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FCER2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATACAGCCA

About this image

FCER2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FCER2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCER2

SOURCE GeneReport for Unigene cluster: Hs.465778

SABiosciences Expression via Pathway-Focused PCR Arrays including FCER2:

Cell Surface Markers in human mouse rat

Antigen Presenting Cells in human mouse rat

Lymphoma in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCER2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FCER2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCER2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCER2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FCER2 gene from 1/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100858751¹	low affinity immunoglobulin epsilon Fc receptor-like	48.64(n) 32.3(a)		100858751 XM_003643371.1 XP_003643419.1

ENSEMBL Gene Tree for FCER2 (if available)
TreeFam Gene Tree for FCER2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FCER2 gene

CD207² CLEC4E² ASGR2² CLEC4M² CLEC4F² CD209² CLEC10A² CLEC4A²

CLEC6A² ASGR1² CLEC4C² CLEC4D² CLEC4G²

18/26 SIMAP similar genes for FCER2 using alignment to 5 protein entries: FCER2_HUMAN (see all proteins) (see all similar genes):

CLEC2D KLRD1 KLRK1 ASGR2 CLEC10A CLEC17A

HBXBP OLR1 KLRC1 KLRC2 CLEC4M CLEC4C

CD69 ASGR1 CD209 KLRC3 MRC2 CLEC2L

FCER2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73489921^1,2	C,F,	--	7753226(+)	`CCTCAG/CCCTCC`	3	--	ds500¹		2		NA WA	10
rs35055364^1,2	C,F,	--	7753256(+)	`GCACAC/TGCCGC`	3	--	ds500¹		2		NA WA	10
rs35522535^1,2	C,	--	7753308(+)	`TTCACC/TGTGTT`	3	--	ds500¹		3		NA WA	6
rs144069391^1,2		--	7753350(+)	`GATCCA/G/TCCTGC`	3	--	ds500¹		0	--	--	--	--
rs56705009^1,2	C,	--	7753358(+)	`TGCCTC/TGGCCT`	3	--	ds500¹		1		WA	2
rs140959444^1,2		--	7753422(+)	`ATTTTG/TAATAG`	3	--	ds500¹		0	--	--	--	--
rs189511695^1,2		--	7753430(+)	`TAGAGA/CCGGGG`	3	--	ds500¹		0	--	--	--	--
rs192247947^1,2		--	7753431(+)	`AGAGAC/TGGGGT`	3	--	ds500¹		0	--	--	--	--
rs58342410^1,2	C,	--	7753444(+)	`TGCCAC/TGTTGG`	3	--	ds500¹		1		WA	2
rs57720845^1,2	C,	--	7753450(+)	`GTTGGG/CCAGGC`	3	--	ds500¹		1		WA	2

HapMap Linkage Disequilibrium report for FCER2 (7753643 - 7767032 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FCER2
5 CNVs: 73308 73307 8863 89053 78054
6 Indels: 89054 78055 78056 61669 60273 89052
Human Gene Mutation Database (HGMD): FCER2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FCER2 for disorders           About GeneDecksing

OMIM gene information: 151445    OMIM disorders: --

20/74 diseases for FCER2 (see all 74):    About MalaCards

splenic marginal zone lymphoma b-cell non-hodgkin lymphoma extrinsic allergic alveolitis diffuse large b-cell lymphoma

non-hodgkin lymphoma dendritic cell sarcoma follicular dendritic cell sarcoma intrinsic asthma

wiskott-aldrich syndrome follicular dendritic cell tumor b-cell lymphomas allergic rhinitis

food allergy severe acute respiratory syndrome severe combined immunodeficiency infectious mononucleosis

bullous pemphigoid primary effusion lymphoma lupus erythematosus hodgkin's lymphoma

4 diseases from the University of Copenhagen DISEASES database for FCER2:

Hypersensitivity reaction type I disease Atopic dermatitis Asthma Allergic rhinitis

10/59 Novoseek disease relationships for FCER2 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphocytic leukemia chronic b-cell	72.4	11	10052715 (2), 15621797 (2), 7517747 (1), 1717071 (1) (see all 9)
leukemia lymphocytic chronic	67.5	17	11064465 (3), 2137545 (2), 8332446 (2), 1532590 (2) (see all 10)
lymphoma small lymphocytic	66.8	3	8058704 (1), 16540722 (1), 10478136 (1)
leukaemia lymphocytic	65.3	17	9508354 (2), 10233382 (2), 7873388 (2), 10713330 (1) (see all 13)
dermatitis atopic	64.6	24	1531123 (4), 9543080 (3), 8453305 (2), 8785171 (2) (see all 15)
leukemia eosinophilic	61.9	2	8589271 (1), 9620595 (1)
asthma allergic	56.3	10	9450145 (3), 1334783 (1), 7653734 (1), 1401914 (1) (see all 7)
chronic conjunctivitis	55.2	2	9191610 (1), 9154386 (1)
burkitt lymphoma	54.8	2	9036969 (1), 1354347 (1)
lymphoma	52.3	22	11211615 (3), 10478136 (3), 8058704 (2), 9508354 (2) (see all 14)

Human Genome Epidemiology (HuGE) Navigator: FCER2 (17 documents)

Export disorders for FCER2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FCER2 gene, integrated from 9 sources (see all 519):
(articles sorted by number of sources associating them with FCER2)

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The structure of human CD23 and its interactions with IgE and CD21. (PubMed id 16172256)^{1, 2, 9} Hibbert R.G....McDonnell J.M. (2005)
Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding. (PubMed id 16765898)^{1, 2, 9} Wurzburg B.A....Jardetzky T.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models. (PubMed id 8745401)^{1, 2} Bajorath J. and Aruffo A. (1996)
Modeling of the lectin-homology domains of the human and murine low- affinity Fc epsilon receptor (Fc epsilon RII/CD23). (PubMed id 8142907)^{1, 2} Padlan E.A. and Helm B.A. (1993)
Partial characterization of natural and recombinant human soluble CD23. (PubMed id 1417742)^{1, 2} Rose K.... Bonnefoy J.-Y. (1992)
Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression. (PubMed id 2972386)^{1, 2} Yokota A.... Kishimoto T. (1988)
Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. (PubMed id 3034567)^{1, 2} Luedin C.... Delespesse G. (1987)
Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins. (PubMed id 2949326)^{1, 2} Ikuta K.... Yodoi J. (1987)
Molecular structure of human lymphocyte receptor for immunoglobulin E. (PubMed id 2877743)^{1, 2} Kikutani H.... Kishimoto T. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2208	HGNC: 3612	AceView: FCER2	Ensembl:ENSG00000104921	euGenes: HUgn2208
ECgene: FCER2	Kegg: 2208	H-InvDB: FCER2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FCER2	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_221

Intellectual Property for FCER2 gene
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Patent Information for FCER2 gene:
Search GeneIP for patents involving FCER2

GeneCards and IP:
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Fc fragment of IgE, low affinity II, receptor for (CD23)

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Nephrotic Syndrome Minimal Change
Acute Disease
Pemphigoid Bullous
Leukemia T-Cell
Leukemia Lymphocytic Chronic
atopy
Malaria
Dermatitis Atopic
Allergic Reaction
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allergy
Leukemia
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Rhinitis Allergic Seasonal
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immunodeficiency
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MYELOMA
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Pneumonitis Hypersensitivity
EBV Infections
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FCER2 Gene

Fc fragment of IgE, low affinity II, receptor for (CD23)

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