Aliases for FCER1G Gene
Aliases for FCER1G Gene
External Ids for FCER1G Gene
- HGNC: 3611
- Entrez Gene: 2207
- Ensembl: ENSG00000158869
- OMIM: 147139
- UniProtKB: P30273
Previous GeneCards Identifiers for FCER1G Gene
- GC01P158896
- GC01P156917
- GC01P157962
- GC01P158402
- GC01P158403
- GC01P157998
- GC01P159451
- GC01P161185
- GC01P132542
Summaries for FCER1G Gene
-
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for FCER1G Gene
FCER1G (Fc Fragment Of IgE Receptor Ig) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Phospholipase D signaling pathway. GO annotations related to this gene include transmembrane signaling receptor activity and IgE binding.
UniProtKB/Swiss-Prot for FCER1G Gene
-
Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1G Gene
Genomics for FCER1G Gene
Regulatory Elements for FCER1G Gene
Enhancers for FCER1G Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCER1G on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCER1G gene promoter:
Regulatory Element Products
Genomic Location for FCER1G Gene
- Chromosome:
- 1
- Start:
- 161,215,234 bp from pter
- End:
- 161,220,699 bp from pter
- Size:
- 5,466 bases
- Orientation:
- Plus strand
Genomic View for FCER1G Gene
Genes around FCER1G on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC
FCER1G Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCER1G Gene
Proteins for FCER1G Gene
-
Protein details for FCER1G Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30273-FCERG_HUMAN
- Recommended name:
- High affinity immunoglobulin epsilon receptor subunit gamma
- Protein Accession:
- P30273
- Q5VTW4
Protein attributes for FCER1G Gene
- Size:
- 86 amino acids
- Molecular mass:
- 9667 Da
- Quaternary structure:
-
- IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.
Protein Expression for FCER1G Gene
Post-translational modifications for FCER1G Gene
Other Protein References for FCER1G Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top FCER1G Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FCER1G
-
Custom Antibody ServicesOriGene Antibodies for FCER1G
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-
Abcam antibodies for FCER1G
- Invitrogen Antibodies for FCER1G
- antibodies-online Antibodies for FCER1G: See all 32
- GeneTex FCER1G antibody for FCER1G
-
Santa Cruz Biotechnology (SCBT) Antibodies for FCER1G
Protein Products
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OriGene Purified Proteins for FCER1G
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- antibodies-online Proteins for FCER1G: See all 3
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-
Abcam proteins for FCER1G
Assay Products
- antibodies-online Kits for FCER1G: See all 4
No data available for DME Specific Peptides for FCER1G Gene
Domains & Families for FCER1G Gene
Protein Domains for FCER1G Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCER1G Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30273- Family:
-
- Belongs to the CD3Z/FCER1G family.
No data available for Gene Families for FCER1G Gene
Function for FCER1G Gene
Molecular function for FCER1G Gene
- GENATLAS Biochemistry:
- immunoglobulin E,high affinity Fc receptor,gamma polypeptide,expressed in most cells,homodimerizing
- UniProtKB/Swiss-Prot Function:
- Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 8810294 |
| GO:0019767 | IgE receptor activity | IEA,IBA | -- |
| GO:0019863 | IgE binding | IEA,IBA | -- |
| GO:0019864 | IgG binding | IEA,IBA | -- |
Phenotypes for FCER1G Gene
- MGI mutant phenotypes for FCER1G:
-
inferred from 3 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for FCER1G:
Animal Models for FCER1G Gene
Animal Model Products
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Taconic Biosciences Mouse Models for FCER1G
-
ViGene Biosciences lentiviral particle packaged cDNA for FCER1G gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCER1G gene
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CRISPR Products
-
OriGene CRISPR knockouts for FCER1G
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCER1G
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miRNA for FCER1G Gene
- miRTarBase miRNAs that target FCER1G
miRNA Products
- Search ViGene Biosciences for FCER1G
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCER1G
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for FCER1G
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCER1G Gene
Localization for FCER1G Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCER1G Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0009897 | external side of plasma membrane | IBA,IEA | -- |
| GO:0009986 | cell surface | IDA | 1535625 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for FCER1G Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response Fc epsilon RI pathway | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 4 | Allograft rejection |
.44
|
|
| 5 | Immune response Role of DAP12 receptors in NK cells | ||
Pathways by source for FCER1G Gene
1 BioSystems pathway for FCER1G Gene
11 Reactome pathways for FCER1G Gene
7 KEGG pathways for FCER1G Gene
2 GeneGo (Thomson Reuters) pathways for FCER1G Gene
2 R&D Systems pathways for FCER1G Gene
5 Qiagen pathways for FCER1G Gene
Interacting Proteins for FCER1G Gene
Selected Interacting proteins:
ENSP00000289902
P30273-FCERG_HUMAN
for FCER1G Gene via
STRING
UniProtKB
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001798 | positive regulation of type IIa hypersensitivity | IEA | -- |
| GO:0001805 | positive regulation of type III hypersensitivity | IEA | -- |
| GO:0001812 | positive regulation of type I hypersensitivity | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002283 | neutrophil activation involved in immune response | IEA,IBA | -- |
No data available for SIGNOR curated interactions for FCER1G Gene
Transcripts for FCER1G Gene
mRNA/cDNA for FCER1G Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (130) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCER1G Gene
CRISPR Products
-
OriGene CRISPR knockouts for FCER1G
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCER1G
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: |
Expression for FCER1G Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Mononucleated Osteoclasts Bone Marrow
- Bone Marrow
- Blood (Cardiovascular System)
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Spleen (Hematopoietic System)
- Brain (Nervous System)
- NULL (Uncategorized)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for FCER1G Gene
This gene is overexpressed in Whole Blood (x35.5).
This gene is overexpressed in Nasal epithelium (22.5), Peripheral blood mononuclear cells (10.7), Platelet (10.3), and NK cells (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER1G Gene
NURSA nuclear receptor signaling pathways regulating expression of FCER1G Gene:
FCER1GSOURCE GeneReport for Unigene cluster for FCER1G Gene:
Hs.433300Evidence on tissue expression from TISSUES for FCER1G Gene
- Blood(4.6)
- Liver(4.3)
- Spleen(3.1)
- Lymph node(2.7)
- Bone marrow(2.6)
- Intestine(2.2)
- Lung(2.2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for FCER1G
-
OriGene qPCR primer pairs and template standards for FCER1G
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER1G Gene
Orthologs for FCER1G Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCER1G 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCER1G 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCER1G 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcer1g 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcer1g 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FCER1G 35 |
|
OneToOne |
- Species where no ortholog for FCER1G was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCER1G Gene
(24) SIMAP similar genes for FCER1G Gene using alignment to 2 proteins:
No data available for Paralogs for FCER1G Gene
Variants for FCER1G Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121434429 | Pathogenic | 161,213,673(+) | TGGTG(C/T)CTGAT | upstream-variant-2KB, reference, missense | |
| rs863224105 | Likely pathogenic | 161,213,661(+) | TTGGG(A/G)TGTAC | upstream-variant-2KB, reference, missense | |
| rs1136207 | Likely benign | 161,213,726(+) | TTTGC(C/T)CATCT | upstream-variant-2KB, reference, synonymous-codon | |
| rs1136224 | Likely benign | 161,214,307(+) | TGTTC(A/G)TGTAC | upstream-variant-2KB, utr-variant-3-prime | |
| rs144411579 | Uncertain significance | 161,213,401(+) | TGATT(C/G)ATCAC | upstream-variant-2KB, reference, missense |
Residual Variation Intolerance Score:
62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.91;
18.84% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCER1G Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCER1G
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER1G Gene
Disorders for FCER1G Gene
Relevant External Links for FCER1G
No disorders were found for FCER1G Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCER1G Gene
Publications for FCER1G Gene
- Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family. (PMID: 2138619) Kuester H. … Kinet J.-P. (J. Biol. Chem. 1990) 2 3 4 64
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
- Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. (PMID: 20028371) Mahachie John J.M. … Weidinger S. (Allergy 2010) 3 46 64
Products for FCER1G Gene
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- antibodies-online Antibodies for FCER1G: See all 32
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- GeneTex FCER1G antibody for FCER1G
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- ViGene Biosciences adenoviral particle packaged cDNA for FCER1G gene
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- VectorBuilder custom plasmid, inducible vectors for FCER1G
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCER1G Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer