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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCER1G Gene

protein-coding   GIFtS: 63
GCID: GC01P161185

Fc Fragment Of IgE, High Affinity I, Receptor For; Gamma...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fc Fragment Of IgE, High Affinity I, Receptor For; Gamma
Polypeptide1 2
     fcRgamma2
Fc-Epsilon RI-Gamma2 3     High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma2
FceRI Gamma2 3     Immunoglobulin E Receptor, High Affinity, Gamma Chain2
Fc Receptor Gamma-Chain2 3     FcRgamma3
FCRG2     IgE Fc Receptor Subunit Gamma3

External Ids:    HGNC: 36111   Entrez Gene: 22072   Ensembl: ENSG000001588697   OMIM: 1471395   UniProtKB: P302733   

Export aliases for FCER1G gene to outside databases

Previous GC identifers: GC01P158896 GC01P156917 GC01P157962 GC01P158402 GC01P158403 GC01P157998 GC01P159451 GC01P132542


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCER1G Gene:
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1
alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. (provided by RefSeq,
Jul 2008)

GeneCards Summary for FCER1G Gene: 
FCER1G (Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide) is a protein-coding gene. Diseases associated with FCER1G include eczema, and urticaria, and among its related super-pathways are Immune response BCR pathway and Role of LAT2/NTAL/LAB on calcium mobilization. GO annotations related to this gene include IgG binding and IgE receptor activity.

UniProtKB/Swiss-Prot: FCERG_HUMAN, P30273
Function: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several
aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach
the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by
integrin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCER1G gene promoter:
         E2F-4   E2F-3a   E2F-5   CUTL1   E2F-2   C/EBPalpha   PPAR-gamma1   E2F   E2F-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCER1G promoter sequence
   Search SABiosciences Chromatin IP Primers for FCER1G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCER1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

FCER1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER1G gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161185:  view genomic region     (about GC identifiers)

Start:
161,185,024 bp from pter      End:
161,190,489 bp from pter
Size:
5,466 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCERG_HUMAN, P30273 (See protein sequence)
Recommended Name: High affinity immunoglobulin epsilon receptor subunit gamma precursor  
Size: 86 amino acids; 9667 Da
Subunit: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The
gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By
similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated
activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be
indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q5VTW4

Explore the universe of human proteins at neXtProt for FCER1G: NX_P30273

Explore proteomics data for FCER1G at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30273

  • FCER1G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FCER1G Protein Expression
    REFSEQ proteins: NP_004097.1  
    ENSEMBL proteins: 
     ENSP00000356971   ENSP00000289902  
    Reactome Protein details: P30273
    Human Recombinant Protein Products for FCER1G: 
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    Novus Biologicals FCER1G Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0032998Fc-epsilon receptor I complex IEA--

    FCER1G for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003110 Phos_immunorcpt_sig_ITAM
     IPR021663 CR3_zeta/IgE_Fc_rcpt_gamma

    Graphical View of Domain Structure for InterPro Entry P30273

    ProtoNet protein and cluster: P30273

    1 Blocks protein domain: IPB003110 Phosphorylated immunoreceptor signaling ITAM

    UniProtKB/Swiss-Prot: FCERG_HUMAN, P30273
    Similarity: Belongs to the CD3Z/FCER1G family
    Similarity: Contains 1 ITAM domain


    FCER1G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCERG_HUMAN, P30273
    Function: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several
    aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach
    the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by
    integrin

         Genatlas biochemistry entry for FCER1G:
    immunoglobulin E,high affinity Fc receptor,gamma polypeptide,expressed in most cells,homodimerizing

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding IPI8810294
    GO:0019767IgE receptor activity IEA--
    GO:0019863IgE binding IEA--
    GO:0019864IgG binding IEA--
         
    FCER1G for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FCER1G:
     Cell cycle / mitosis defect 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fcer1g):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  nervous system  renal/urinary system  reproductive system  skeleton 

    FCER1G for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FCER1G: Fcer1gtm1Tks Fcer1gtm1Rav

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FCER1G 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCER1G 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCER1G 

    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FCER1G About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Fc-epsilon receptor I signaling in mast cells0.33
    Fc epsilon RI signaling pathway0.40
    Natural killer cell mediated cytotoxicity0.31
    2Fc epsilon receptor (FCERI) signaling
    Fc epsilon receptor (FCERI) signaling0.69
    Role of LAT2/NTAL/LAB on calcium mobilization0.69
    3FCERI mediated Ca+2 mobilization
    FCERI mediated Ca+2 mobilization0.60
    FCERI mediated MAPK activation0.60
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    5Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for FCER1G
        Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway

    1 R&D Systems Pathway for FCER1G
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FCER1G
        NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling
    Fc-EpsilonRI Pathway
    NFAT in Immune Response
    Phagocytosis of Microbes

    2 GeneGo (Thomson Reuters) Pathways for FCER1G
        Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    1 BioSystems Pathway for FCER1G
        Fc-epsilon receptor I signaling in mast cells


    5/12        Reactome Pathways for FCER1G (see all 12)
        Hemostasis
    Platelet Adhesion to exposed collagen
    FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    Role of LAT2/NTAL/LAB on calcium mobilization


    4         Kegg Pathways  (Kegg details for FCER1G):
        Natural killer cell mediated cytotoxicity
    Fc epsilon RI signaling pathway
    Tuberculosis
    Asthma


    FCER1G for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCER1G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for FCER1G (P302732, 3 ENSP000002899024) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434052, 3, ENSP000003648984MINT-8028449 I2D: score=6 STRING: ENSP00000364898
    PLCG2P168853, ENSP000003523364I2D: score=3 STRING: ENSP00000352336
    BTKQ061873, ENSP000003081764I2D: score=2 STRING: ENSP00000308176
    FCGR3AP086373, ENSP000003569464I2D: score=2 STRING: ENSP00000356946
    GP6Q9HCN63, ENSP000003087824I2D: score=2 STRING: ENSP00000308782
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001798positive regulation of type IIa hypersensitivity IEA--
    GO:0001805positive regulation of type III hypersensitivity IEA--
    GO:0001812positive regulation of type I hypersensitivity IEA--
    GO:0002283neutrophil activation involved in immune response IEA--
    GO:0002431Fc receptor mediated stimulatory signaling pathway IEA--

    FCER1G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCER1G for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FCER1G (FCERG)

    1 DrugBank Compound for FCER1G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzylpenicilloyl Polylysine-- 2642-55-9targetagonist7436456 17139284 11752352 17016423

    1 Novoseek inferred chemical compound relationship for FCER1G gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 7.39 1 8265641 (1)

    1 PharmGKB related drug/compound annotation for FCER1G gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  

    Search CenterWatch for drugs/clinical trials and news about FCER1G / FCERG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for FCER1G gene: 
    NM_004106.1  

    Unigene Cluster for FCER1G:

    Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
    Hs.433300  [show with all ESTs]
    Unigene Representative Sequence: BI909222
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490414 ENST00000367992 ENST00000289902(uc001fyz.1 uc001fza.1)

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    Additional mRNA sequence: 

    AK307102.1 BC033872.1 M33195.1 

    4 DOTS entries:

    DT.451781  DT.92424994  DT.95275345  DT.121463647 

    24/130 AceView cDNA sequences (see all 130):

    CA413064 BU786848 AI127246 R80909 BM662950 N98747 AW951597 AI830761 
    AA513769 M33195 BM694296 AA699470 NM_004106 CD364792 BU786099 CD364626 
    BU789936 BX089542 BU782817 BI521452 AV714510 BM686106 AI004320 AI126565 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FCER1G    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for FCER1G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCER1G expression in normal human tissues (normalized intensities)      FCER1G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGGAAAA
    FCER1G Expression
    About this image


    FCER1G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 14 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Mast-like cells ( Generation of hematopoietic progenitor cells and mast cells )
             Fetal Liver CD36+ Cells   
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Septum   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood Natural Killer Cells (CD56+)   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             Conventional Dendritic Cells II Spleen
             spleen ; cells in red pulp   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             lung ; macrophages   

    See FCER1G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FCER1G

    SOURCE GeneReport for Unigene cluster: Hs.433300
        SABiosciences Custom PCR Arrays for FCER1G
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCER1G gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcer1g1 , 5 Fc receptor, IgE, high affinity I, gamma polypeptide1, 5 88.37(n)1
    88.37(a)1
      1 (79.23 cM)5
    141271  NM_010185.41  NP_034315.11 
     1712295725 


    ENSEMBL Gene Tree for FCER1G (if available)
    TreeFam Gene Tree for FCER1G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCER1G gene
    18/26 SIMAP similar genes for FCER1G using alignment to 2 protein entries:     FCERG_HUMAN (see all proteins) (see all similar genes):
    DYNC2LI1    RRM2B    EEF1E1    MRPL45    UTY    FAM3A
    ZNF66    ADCK1    TFR2    ZNF799    ADRA1A    RAD51
    CCDC122    CD247    LOC100996426    NLRC5    SNRPF    SH2B3

    FCER1G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/120 SNPs in FCER1G are shown (see all 120)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710903691,2
    C--132543163(-) CTATA-/CT/TA 
            
    TATAT
    1 -- int11NA 2
    rs1509570271,2
    --161184763(+) TTGCAC/TTCCAG 1 -- us2k10--------
    rs1886922491,2
    --161184842(+) GGAAAA/TTGGCA 1 -- us2k10--------
    rs115872131,2
    C,F,A,H--161184875(+) CGTGAA/GAGTCT 1 -- us2k130Minor allele frequency- N:0.00EA NA NS MN CSA 3257
    rs1917565471,2
    --161184909(+) GGTCAC/TTGAAG 1 -- us2k10--------
    rs412708471,2
    C--161184976(+) CGCCCA/GGTCTC 1 -- us2k10--------
    rs1838797881,2
    --161185037(+) GAGGGA/GGACTC 1 -- us2k10--------
    rs20709011,2
    C,F,O,A--161185058(+) GAACTG/TCTCGC 1 -- us2k116Minor allele frequency- N:0.00EA NA NS WA CSA 2494
    rs1132208671,2
    C--161185096(+) ACGGCG/CGATCT 1 -- ut511Minor allele frequency- C:0.50CSA 2
    rs1128392851,2
    C--161185097(+) CGGCCA/GATCTC 1 -- ut511Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for FCER1G (161185024 - 161190489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FCER1G:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv482136CNV Loss20164927

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147139    OMIM disorders: --

    14 diseases for FCER1G:    About MalaCards
    eczema    urticaria    nephrotic syndrome    aplastic anemia
    meningioma    atopic dermatitis    hepatitis b    asthma
    dermatitis    chronic lymphocytic leukemia    anemia    hepatitis
    tuberculosis    leukemia


    FCER1G for disorders           About GeneDecksing

    Genetic Association Database (GAD): FCER1G
    Human Genome Epidemiology (HuGE) Navigator: FCER1G (15 documents)

    Export disorders for FCER1G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCER1G gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with FCER1G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family. (PubMed id 2138619)1, 2, 3 Kuester H.... Kinet J.-P. (1990)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Analysis of the high affinity IgE receptor genes reve als epistatic effects of FCER1A variants on eczema risk. (PubMed id 20028371)1, 4 Mahachie John J.M....Weidinger S. (2009)
    6. Analysis of high-affinity IgE receptor (FcepsilonR1) polymorphisms in patients with aspirin-intolerant chronic urticaria. (PubMed id 18534082)1, 4 Palikhe N....Park H.S. (2008)
    7. Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness. (PubMed id 17430357)1, 4 Kim Y.K....Kim Y.Y. (2007)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. Conservation of FcepsilonRI gamma chain coding region in normals and in SLE patients. (PubMed id 11898918)1, 4 Wu J....Kimberly R.P. (2002)
    10. Type I IgE receptor, interleukin 4 receptor and interleukin 13 polymorphisms in children with nephrotic syndrome. (PubMed id 11980568)1, 4 Tenbrock K....Michalk D. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2207 HGNC: 3611 AceView: FCER1G Ensembl:ENSG00000158869 euGenes: HUgn2207
    ECgene: FCER1G Kegg: 2207 H-InvDB: FCER1G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCER1G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FCER1G gene:
    Search GeneIP for patents involving FCER1G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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