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Aliases for FCER1G Gene

Aliases for FCER1G Gene

  • Fc Fragment Of IgE Receptor Ig 2 3 5
  • Fc Fragment Of IgE, High Affinity I, Receptor For; Gamma Polypeptide 2 3
  • Fc Receptor Gamma-Chain 3 4
  • Fc Epsilon Receptor Ig 2 3
  • Fc-Epsilon RI-Gamma 3 4
  • FceRI Gamma 3 4
  • FcRgamma 3 4
  • High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma 3
  • Immunoglobulin E Receptor, High Affinity, Gamma Chain 3
  • IgE Fc Receptor Subunit Gamma 4
  • FCRG 3

External Ids for FCER1G Gene

Previous GeneCards Identifiers for FCER1G Gene

  • GC01P158896
  • GC01P156917
  • GC01P157962
  • GC01P158402
  • GC01P158403
  • GC01P157998
  • GC01P159451
  • GC01P161185
  • GC01P132542

Summaries for FCER1G Gene

Entrez Gene Summary for FCER1G Gene

  • The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCER1G Gene

FCER1G (Fc Fragment Of IgE Receptor Ig) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Phospholipase D signaling pathway. GO annotations related to this gene include transmembrane signaling receptor activity and IgE binding.

UniProtKB/Swiss-Prot for FCER1G Gene

  • Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1G Gene

Genomics for FCER1G Gene

Regulatory Elements for FCER1G Gene

Enhancers for FCER1G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G160738 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -473.1 -473090 8.0 HDGF PKNOX1 WRNIP1 ZNF133 YY1 GATA2 ZNF143 ZNF207 JUNB TBX21 SLAMF7 FCER1G CD48 CD244 ARHGAP30 COPA ENSG00000275801
GH01G161388 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.6 +174.7 174702 2.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 SDHC ATF6 CFAP126 NR1I3 APOA2 TOMM40L MPZ FCRLA FCER1G FCGR2A
GH01G160726 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -488.4 -488433 1.6 HDGF WRNIP1 YBX1 YY1 ZNF766 ELK1 ZNF143 ZNF207 GTF2B REST SLAMF7 LY9 ENSG00000228863 ITLN1 SLAMF1 CD48 FCER1G CD244 ENSG00000202078 GC01P160735
GH01G160766 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -447.4 -447377 2.4 HDGF TBP PKNOX1 ATF1 CBX3 TBL1XR1 WRNIP1 SIN3A RAD21 YY1 SLAMF7 CD244 LY9 ENSG00000228863 ITLN1 SLAMF1 CD48 FCER1G ENSG00000275801
GH01G160788 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -425.0 -424984 2.6 HDGF TBP PKNOX1 ATF1 BMI1 RFX5 ZNF143 FOS RELB IKZF2 SLAMF7 ITLN1 ENSG00000228863 CD48 CD244 FCER1G COPA TSTD1 LY9 ARHGAP30
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCER1G on UCSC Golden Path with GeneCards custom track

Promoters for FCER1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014660 1066 1801 PKNOX1 ZSCAN4 YY1 GATA2 ZNF143 ETV6 FOS RELB CREM IKZF2

Genomic Location for FCER1G Gene

Chromosome:
1
Start:
161,215,234 bp from pter
End:
161,220,699 bp from pter
Size:
5,466 bases
Orientation:
Plus strand

Genomic View for FCER1G Gene

Genes around FCER1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCER1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCER1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER1G Gene

Proteins for FCER1G Gene

  • Protein details for FCER1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30273-FCERG_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit gamma
    Protein Accession:
    P30273
    Secondary Accessions:
    • Q5VTW4

    Protein attributes for FCER1G Gene

    Size:
    86 amino acids
    Molecular mass:
    9667 Da
    Quaternary structure:
    • IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.

neXtProt entry for FCER1G Gene

Post-translational modifications for FCER1G Gene

  • Ubiquitination at isoforms=60
  • Modification sites at PhosphoSitePlus

Other Protein References for FCER1G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FCER1G

No data available for DME Specific Peptides for FCER1G Gene

Domains & Families for FCER1G Gene

Suggested Antigen Peptide Sequences for FCER1G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30273

UniProtKB/Swiss-Prot:

FCERG_HUMAN :
  • Belongs to the CD3Z/FCER1G family.
Family:
  • Belongs to the CD3Z/FCER1G family.
genes like me logo Genes that share domains with FCER1G: view

No data available for Gene Families for FCER1G Gene

Function for FCER1G Gene

Molecular function for FCER1G Gene

GENATLAS Biochemistry:
immunoglobulin E,high affinity Fc receptor,gamma polypeptide,expressed in most cells,homodimerizing
UniProtKB/Swiss-Prot Function:
Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.

Gene Ontology (GO) - Molecular Function for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 8810294
GO:0019767 IgE receptor activity IEA,IBA --
GO:0019863 IgE binding IEA,IBA --
GO:0019864 IgG binding IEA,IBA --
genes like me logo Genes that share ontologies with FCER1G: view
genes like me logo Genes that share phenotypes with FCER1G: view

Animal Models for FCER1G Gene

MGI Knock Outs for FCER1G:

Animal Model Products

CRISPR Products

miRNA for FCER1G Gene

miRTarBase miRNAs that target FCER1G

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCER1G Gene

Localization for FCER1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER1G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCER1G gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IBA,IEA --
GO:0009986 cell surface IDA 1535625
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FCER1G: view

Pathways & Interactions for FCER1G Gene

genes like me logo Genes that share pathways with FCER1G: view

Gene Ontology (GO) - Biological Process for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001798 positive regulation of type IIa hypersensitivity IEA --
GO:0001805 positive regulation of type III hypersensitivity IEA --
GO:0001812 positive regulation of type I hypersensitivity IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002283 neutrophil activation involved in immune response IEA,IBA --
genes like me logo Genes that share ontologies with FCER1G: view

No data available for SIGNOR curated interactions for FCER1G Gene

Drugs & Compounds for FCER1G Gene

(4) Drugs for FCER1G Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzylpenicilloyl Polylysine Approved Pharma binder, Target, agonist 0
Aspirin Approved, Vet_approved Pharma Channel blocker 1152
R112 Pharma 0
genes like me logo Genes that share compounds with FCER1G: view

Transcripts for FCER1G Gene

mRNA/cDNA for FCER1G Gene

Unigene Clusters for FCER1G Gene

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCER1G Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for FCER1G Gene

GeneLoc Exon Structure for
FCER1G
ECgene alternative splicing isoforms for
FCER1G

Expression for FCER1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCER1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER1G Gene

This gene is overexpressed in Whole Blood (x35.5).

Protein differential expression in normal tissues from HIPED for FCER1G Gene

This gene is overexpressed in Nasal epithelium (22.5), Peripheral blood mononuclear cells (10.7), Platelet (10.3), and NK cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER1G Gene



Protein tissue co-expression partners for FCER1G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCER1G Gene:

FCER1G

SOURCE GeneReport for Unigene cluster for FCER1G Gene:

Hs.433300

Evidence on tissue expression from TISSUES for FCER1G Gene

  • Blood(4.6)
  • Liver(4.3)
  • Spleen(3.1)
  • Lymph node(2.7)
  • Bone marrow(2.6)
  • Intestine(2.2)
  • Lung(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with FCER1G: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER1G Gene

Orthologs for FCER1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCER1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCER1G 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia FCER1G 34 35
  • 92.54 (n)
cow
(Bos Taurus)
Mammalia FCER1G 34 35
  • 91.76 (n)
mouse
(Mus musculus)
Mammalia Fcer1g 34 16 35
  • 89.05 (n)
rat
(Rattus norvegicus)
Mammalia Fcer1g 34
  • 87.98 (n)
oppossum
(Monodelphis domestica)
Mammalia FCER1G 35
  • 70 (a)
OneToOne
Species where no ortholog for FCER1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER1G Gene

ENSEMBL:
Gene Tree for FCER1G (if available)
TreeFam:
Gene Tree for FCER1G (if available)

Paralogs for FCER1G Gene

genes like me logo Genes that share paralogs with FCER1G: view

No data available for Paralogs for FCER1G Gene

Variants for FCER1G Gene

Sequence variations from dbSNP and Humsavar for FCER1G Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs121434429 Pathogenic 161,213,673(+) TGGTG(C/T)CTGAT upstream-variant-2KB, reference, missense
rs863224105 Likely pathogenic 161,213,661(+) TTGGG(A/G)TGTAC upstream-variant-2KB, reference, missense
rs1136207 Likely benign 161,213,726(+) TTTGC(C/T)CATCT upstream-variant-2KB, reference, synonymous-codon
rs1136224 Likely benign 161,214,307(+) TGTTC(A/G)TGTAC upstream-variant-2KB, utr-variant-3-prime
rs144411579 Uncertain significance 161,213,401(+) TGATT(C/G)ATCAC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FCER1G Gene

Variant ID Type Subtype PubMed ID
nsv482136 CNV loss 20164927

Variation tolerance for FCER1G Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCER1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCER1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER1G Gene

Disorders for FCER1G Gene

Relevant External Links for FCER1G

Genetic Association Database (GAD)
FCER1G
Human Genome Epidemiology (HuGE) Navigator
FCER1G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCER1G

No disorders were found for FCER1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCER1G Gene

Publications for FCER1G Gene

  1. Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family. (PMID: 2138619) Kuester H. … Kinet J.-P. (J. Biol. Chem. 1990) 2 3 4 64
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. (PMID: 20028371) Mahachie John J.M. … Weidinger S. (Allergy 2010) 3 46 64

Products for FCER1G Gene

Sources for FCER1G Gene

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