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Aliases for FCER1G Gene

Aliases for FCER1G Gene

  • Fc Fragment Of IgE, High Affinity I, Receptor For; Gamma Polypeptide 2 3
  • Fc Receptor Gamma-Chain 3 4
  • Fc-Epsilon RI-Gamma 3 4
  • FceRI Gamma 3 4
  • FcRgamma 3 4
  • High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma 3
  • Immunoglobulin E Receptor, High Affinity, Gamma Chain 3
  • IgE Fc Receptor Subunit Gamma 4
  • FCRG 3

External Ids for FCER1G Gene

Previous GeneCards Identifiers for FCER1G Gene

  • GC01P158896
  • GC01P156917
  • GC01P157962
  • GC01P158402
  • GC01P158403
  • GC01P157998
  • GC01P159451
  • GC01P161185
  • GC01P132542

Summaries for FCER1G Gene

Entrez Gene Summary for FCER1G Gene

  • The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCER1G Gene

FCER1G (Fc Fragment Of IgE, High Affinity I, Receptor For; Gamma Polypeptide) is a Protein Coding gene. Diseases associated with FCER1G include aplastic anemia. Among its related pathways are PI-3K cascade and Akt Signaling. GO annotations related to this gene include IgG binding and IgE receptor activity.

UniProtKB/Swiss-Prot for FCER1G Gene

  • Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1G Gene

Genomics for FCER1G Gene

Regulatory Elements for FCER1G Gene

Genomic Location for FCER1G Gene

Start:
161,215,234 bp from pter
End:
161,220,699 bp from pter
Size:
5,466 bases
Orientation:
Plus strand

Genomic View for FCER1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCER1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER1G Gene

Proteins for FCER1G Gene

  • Protein details for FCER1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30273-FCERG_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit gamma
    Protein Accession:
    P30273
    Secondary Accessions:
    • Q5VTW4

    Protein attributes for FCER1G Gene

    Size:
    86 amino acids
    Molecular mass:
    9667 Da
    Quaternary structure:
    • IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A. Associated with CLEC6A (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with CLEC4E.

neXtProt entry for FCER1G Gene

Proteomics data for FCER1G Gene at MOPED

Post-translational modifications for FCER1G Gene

  • Ubiquitination at Lys60
  • Modification sites at PhosphoSitePlus

Other Protein References for FCER1G Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FCER1G Gene

Domains for FCER1G Gene

Suggested Antigen Peptide Sequences for FCER1G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30273

UniProtKB/Swiss-Prot:

FCERG_HUMAN :
  • P30273
Domain:
  • Contains 1 ITAM domain.
Family:
  • Belongs to the CD3Z/FCER1G family.
genes like me logo Genes that share domains with FCER1G: view

No data available for Gene Families for FCER1G Gene

Function for FCER1G Gene

Molecular function for FCER1G Gene

GENATLAS Biochemistry: immunoglobulin E,high affinity Fc receptor,gamma polypeptide,expressed in most cells,homodimerizing
UniProtKB/Swiss-Prot Function: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.

Gene Ontology (GO) - Molecular Function for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0005515 protein binding IPI 8810294
GO:0019767 IgE receptor activity IEA --
GO:0019863 IgE binding IEA --
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCER1G: view
genes like me logo Genes that share phenotypes with FCER1G: view

Animal Models for FCER1G Gene

MGI Knock Outs for FCER1G:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCER1G

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FCER1G Gene

Localization for FCER1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER1G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCER1G Gene COMPARTMENTS Subcellular localization image for FCER1G gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 1535625
GO:0016020 membrane --
genes like me logo Genes that share ontologies with FCER1G: view

Pathways for FCER1G Gene

genes like me logo Genes that share pathways with FCER1G: view

Gene Ontology (GO) - Biological Process for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001798 positive regulation of type IIa hypersensitivity IEA --
GO:0001805 positive regulation of type III hypersensitivity IEA --
GO:0001812 positive regulation of type I hypersensitivity IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002283 neutrophil activation involved in immune response IEA --
genes like me logo Genes that share ontologies with FCER1G: view

Compounds for FCER1G Gene

(1) Drugbank Compounds for FCER1G Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Benzylpenicilloyl Polylysine
2642-55-9 target agonist

(1) Novoseek inferred chemical compound relationships for FCER1G Gene

Compound -log(P) Hits PubMed IDs
tyrosine 7.39 1

(1) PharmGKB related drug/compound annotations for FCER1G Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with FCER1G: view

Transcripts for FCER1G Gene

mRNA/cDNA for FCER1G Gene

Unigene Clusters for FCER1G Gene

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCER1G

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCER1G Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for FCER1G Gene

GeneLoc Exon Structure for
FCER1G
ECgene alternative splicing isoforms for
FCER1G

Expression for FCER1G Gene

mRNA expression in normal human tissues for FCER1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER1G Gene

This gene is overexpressed in Whole Blood (35.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCER1G Gene

SOURCE GeneReport for Unigene cluster for FCER1G Gene Hs.433300

genes like me logo Genes that share expressions with FCER1G: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FCER1G Gene

Orthologs for FCER1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCER1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCER1G 35
  • 99.61 (n)
  • 100 (a)
FCER1G 36
  • 60 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCER1G 35
  • 91.76 (n)
  • 94.12 (a)
FCER1G 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCER1G 35
  • 92.54 (n)
  • 95.52 (a)
FCER1G 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcer1g 35
  • 89.05 (n)
  • 89.55 (a)
Fcer1g 16
Fcer1g 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCER1G 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcer1g 35
  • 87.98 (n)
  • 90.7 (a)
Species with no ortholog for FCER1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER1G Gene

ENSEMBL:
Gene Tree for FCER1G (if available)
TreeFam:
Gene Tree for FCER1G (if available)

Paralogs for FCER1G Gene

Selected SIMAP similar genes for FCER1G Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FCER1G: view

No data available for Paralogs for FCER1G Gene

Variants for FCER1G Gene

Sequence variations from dbSNP and Humsavar for FCER1G Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3557 -- 161,219,103(+) CCCTG(G/T)TAAAG utr-variant-3-prime
rs11421 -- 161,219,146(+) TATTC(C/T)AGTCT utr-variant-3-prime
rs1126657 -- 161,219,177(+) CTTCT(C/T)TTCCC utr-variant-3-prime
rs1803572 -- 161,219,081(+) ATATA(C/T)ACCAG utr-variant-3-prime
rs2070901 -- 161,215,268(+) GAACT(G/T)CTCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FCER1G Gene

Variant ID Type Subtype PubMed ID
nsv482136 CNV Loss 20164927

Relevant External Links for FCER1G Gene

HapMap Linkage Disequilibrium report
FCER1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER1G Gene

Disorders for FCER1G Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FCER1G Gene including...

Search for FCER1G Gene in MalaCards »

Relevant External Links for FCER1G

Genetic Association Database (GAD)
FCER1G
Human Genome Epidemiology (HuGE) Navigator
FCER1G
genes like me logo Genes that share disorders with FCER1G: view

No data available for UniProtKB/Swiss-Prot for FCER1G Gene

Publications for FCER1G Gene

  1. Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family. (PMID: 2138619) Kuester H. … Kinet J.-P. (J. Biol. Chem. 1990) 2 3 4
  2. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. (PMID: 17850179) Cao W. … Liu Y.J. (PLoS Biol. 2007) 3 23
  3. Conservation of FcepsilonRI gamma chain coding region in normals and in SLE patients. (PMID: 11898918) Wu J. … Kimberly R.P. (Lupus 2002) 3 48
  4. Type I IgE receptor, interleukin 4 receptor and interleukin 13 polymorphisms in children with nephrotic syndrome. (PMID: 11980568) Tenbrock K. … Michalk D. (Clin. Sci. 2002) 3 48
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for FCER1G Gene

Sources for FCER1G Gene

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