Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCER1A Gene

protein-coding   GIFtS: 60
GCID: GC01P159259

Fc fragment of IgE, high affinity I, receptor for; alpha...


(Previous symbol: FCE1A)
 Explore 22 diseases affiliated with
FCER1A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FCER1A    

Aliases
for FCER1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide1 2     Fc Epsilon RI Alpha-Chain2
FCE1A1 2 3     Fc IgE Receptor, Alpha Polypeptide2
IgE Fc Receptor Subunit Alpha2 3     High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit2
FcERI2 3     High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha2
Fc-Epsilon RI-Alpha2 3     Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide2

External Ids:    HGNC: 36091   Entrez Gene: 22052   Ensembl: ENSG000001796397   OMIM: 1471405   UniProtKB: P123193   

Export aliases for FCER1A gene to outside databases

Previous GC identifers: GC01P157051 GC01P154991 GC01P156037 GC01P156476 GC01P156072 GC01P157526 GC01P130616


Summaries
for FCER1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FCER1A:
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more
high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are
responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two
gamma subunits. The protein encoded by this gene represents the alpha subunit. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319
Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the
allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators
(such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of
important lymphokines

Gene Wiki entry for FCER1A


Genomic Views
for FCER1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCER1A gene promoter:
         c-Fos   AP-1   Fra-1   FosB   NF-kappaB   C/EBPalpha   Cart-1   Sox9   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCER1A promoter sequence
   Search SABiosciences Chromatin IP Primers for FCER1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCER1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23

FCER1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159259:  view genomic region     (about GC identifiers)

Start:
 159,259,504 bp from pter      End:
 159,278,014 bp from pter
Size:
 18,511 bases      Orientation:
 plus strand

Proteins
for FCER1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319 (See protein sequence)
Recommended Name: High affinity immunoglobulin epsilon receptor subunit alpha precursor  
Size: 257 amino acids; 29596 Da
Subunit: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains
Subcellular location: Cell membrane; Single-pass type I membrane protein
6/10 PDB 3D structures from and Proteopedia for FCER1A (see all 10):
1ALS (3D)        1ALT (3D)        1F2Q (3D)        1F6A (3D)        1J86 (3D)        1J87 (3D)    

Explore the universe of human proteins at neXtProt for FCER1A: NX_P12319

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12319

    • FCER1A Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_001992.1  
    ENSEMBL proteins: 
     ENSP00000357097   ENSP00000357096  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCER1A (Fc epsilon RI alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: FCER1A
    OriGene Custom Protein Services for FCER1A 
    GenScript Custom Purified and Recombinant Proteins Services for FCER1A
    Novus Biologicals FCER1A Protein
    Novus Biologicals FCER1A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS1535625
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--


    FCER1A for ontologies           About GeneDecksing



    FCER1A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FCER1A
    R&D Systems Antibodies for FCER1A (Fc epsilon RI alpha)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FCER1A 
    GenScript Custom Superior Antibodies Services for FCER1A
    Novus Biologicals FCER1A Antibodies
    Search for Antibodies for FCER1A at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for FCER1A

    Assay Products for FCER1A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FCER1A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for FCER1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FCER1A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P12319

    ProtoNet protein and cluster: P12319

    1 Blocks protein family: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    Function
    for FCER1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319
    Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the
    allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators
    (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of
    important lymphokines

         Genatlas biochemistry entry for FCER1A:
    immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a
    homodimeric gamma subunit

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCER1A
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FCER1A:
    hsa-miR-4272 hsa-miR-526b hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: FCER1A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCER1A (see all 7)
    OriGene shRNA RFP: FCER1A
    OriGene siRNA: FCER1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCER1A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FCER1A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCER1A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCER1A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FCER1A (NM_002001)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCER1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER1A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FCER1A
    Search LifeMap BioReagents cell lines for FCER1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019767IgE receptor activity IEA--
    GO:0019863IgE binding IEA--


    FCER1A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for FCER1A: Fcer1atm1Knt Fcer1atm1Ftl
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fcer1a):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 

    FCER1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FCER1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway1.00
    		Fc-epsilon receptor I signaling in mast cells0.33
    		Immune response_Fc epsilon RI pathway0.99
    2Immune response_NFAT in immune response
    		Immune response_NFAT in immune response1.00
    		Immune response NFAT in immune response0.91
    3Phagocytosis of Microbes
    		Phagocytosis of Microbes1.00
    4IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    		IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types1.00
    5GPCR Pathway
    		NFAT in Immune Response0.58

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FCER1A
        Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway

    1 R&D Systems Pathway for FCER1A
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FCER1A
        NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling
    Fc-EpsilonRI Pathway
    NFAT in Immune Response
    Phagocytosis of Microbes

    2 GeneGo (Thomson Reuters) Pathways for FCER1A
        Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    1 BioSystems Pathway for FCER1A 
        Fc-epsilon receptor I signaling in mast cells


    2         Kegg Pathways  (Kegg details for FCER1A):
        Fc epsilon RI signaling pathway
    Asthma


    FCER1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCER1A

    4 Interacting proteins for FCER1A (P123193) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCER1GP302733I2D: score=2 
    ITIH2P198233I2D: score=1 
    MS4A2Q013623I2D: score=1 
    VAV1P154983I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0001812positive regulation of type I hypersensitivity IEA--
    GO:0001820serotonin secretion IEA--
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ----


    FCER1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for FCER1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCER1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCER1A

    3 DrugBank Compounds for FCER1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzylpenicilloyl Polylysine-- 2642-55-9targetagonist7436456 17139284 11752352 17016423
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Omalizumab-- 242138-07-4target--17368811 15356552

    2 Novoseek chemical compound relationships for FCER1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    omalizumab 62.1 1 15356552 (1)
    histamine 49.9 2 7685756 (1), 8618029 (1)

    Search CenterWatch for drugs/clinical trials and news about FCER1A / FCERA 

    Transcripts
    for FCER1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FCER1A gene: 
    NM_002001.3  

    Unigene Cluster for FCER1A:

    Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
    Hs.897  [show with all ESTs]
    Unigene Representative Sequence: NM_002001
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368115(uc001ftq.3) ENST00000368114

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCER1A
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FCER1A:
    hsa-miR-4272 hsa-miR-526b hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: FCER1A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCER1A (see all 7)
    OriGene shRNA RFP: FCER1A
    OriGene siRNA: FCER1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCER1A
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCER1A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCER1A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FCER1A (NM_002001)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCER1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER1A 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCER1A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCER1A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCER1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCER1A

    Additional cDNA sequence: 

    BC005912.1 BC015195.1 J03605.1 X06948.1 

    2 DOTS entries:

    DT.307957  DT.92037574 

    24/27 AceView cDNA sequences (see all 27):

    BC015185 BQ005218 X06948 CA419024 J03605 BC005912 NM_002001 CA448745 
    BF679057 BX110472 BC015195 BM991911 BG542157 BQ573778 BG542554 AI676097 
    AW612525 BF678252 BF675157 BG548515 BF593204 AI685796 BF677190 CD696486 

    GeneLoc Exon Structure


    Expression
    for FCER1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCER1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATGGGAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FCER1A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mast-like cells (Generation of hemato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for FCER1A

    SOURCE GeneReport for Unigene cluster: Hs.897
        SABiosciences Expression via Pathway-Focused PCR Arrays including FCER1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCER1A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCER1A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCER1A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCER1A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A

    Orthologs
    for FCER1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FCER1A gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 --
    		 16(a)
    		 1 → many
    		 25(1707231-1709870)


    ENSEMBL Gene Tree for FCER1A (if available)
    TreeFam Gene Tree for FCER1A (if available) 

    Paralogs
    for FCER1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCER1A gene
    FCGR2B2  FCGR1B2  FCGR3B2  FCRL22  FCRLB2  FCRL12  FCRL42  FCRL52  
    FCRLA2  FCGR1A2  FCGR2A2  FCGR3A2  FCRL32  FCRL62  
    12 SIMAP similar genes for FCER1A using alignment to 3 protein entries:     FCERA_HUMAN (see all proteins):
    FCGR1A    FCGR1B    FCGR1C    FCRLB    FCGR2A    Fc-gamma receptor IIIB
    FCGR3A    DKFZp686L20250    FCRL4    FCGR3B    FCGR2C    FCGR2B

    FCER1A for paralogs           About GeneDecksing



    Genomic Variants
    for FCER1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/410 NCBI SNPs in FCER1A are shown (see all 410)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120316561,2
    		H--159251875(+) GGGCCA/GGTTCT 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs1484697141,2
    		C,--159251984(+) GAATG-/AAAAAA 1 -- us2k10--------
    rs109087031,2
    		C,F,A,--159252002(+) AGGTGG/ACAGAA 1 -- us2k111Minor allele frequency- A:0.45NA WA CSA EA 373
    rs168419751,2
    		C,F,--159252040(+) TTCCTG/TCAATT 1 -- us2k14Minor allele frequency- T:0.04NA WA 260
    rs121271021,2
    		C,--159252043(+) CTGCAA/GTTGCA 1 -- us2k14Minor allele frequency- G:0.08CSA WA NA 241
    rs1406627411,2
    		--159252205(+) TTTTGC/TAACAC 1 -- us2k10--------
    rs2013930321,2
    		--159252265(+) CTAAA-/TTTTTT 1 -- us2k10--------
    rs1446262591,2
    		--159252399(+) CAGGTA/GCTTCA 1 -- us2k10--------
    rs1904453661,2
    		--159252426(+) GAATAC/TAACTG 1 -- us2k10--------
    rs1816844871,2
    		--159252653(+) GAAGGA/TTATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCER1A (159259504 - 159278014 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FCER1A: --
    Human Gene Mutation Database (HGMD): FCER1A

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCER1A
    DNA2.0 Custom Variant and Variant Library Synthesis for FCER1A

    Disorders / Diseases
    for FCER1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FCER1A for disorders           About GeneDecksing

    OMIM gene information: 147140    OMIM disorders: --

    20/22 diseases for FCER1A (see all 22):    About MalaCards
    allergic rhinitis    wegener's granulomatosis    urticaria    aggressive periodontitis
    inflammatory bowel disease    atopic dermatitis    rhinitis    allergic asthma
    bronchiolitis    eczema    dermatitis    periodontitis
    hepatitis b    vasculitis    asthma    meningioma
    nephropathy    breast cancer    hepatitis    leukemia

    3 diseases from the University of Copenhagen DISEASES database for FCER1A:
    Urticaria     Hypersensitivity reaction type I disease     Asthma

    3 Novoseek disease relationships for FCER1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    idiopathic urticaria 62.7 1 8618029 (1)
    allergy 28.2 3 18726713 (1), 8543773 (1)
    allergic rhinitis 26.7 1 8543773 (1)

    Genetic Association Database (GAD): FCER1A
    Human Genome Epidemiology (HuGE) Navigator: FCER1A (29 documents)

    Export disorders for FCER1A gene to outside databases

    Publications
    for FCER1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCER1A gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with FCER1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PubMed id 8245459)1, 3, 9 Pang J....Zhou L. (1993)
    2. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PubMed id 11531339)1, 2, 9 Garman S.C....Jardetzky T.S. (2001)
    3. High-level expression of the truncated alpha chain of human high- affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PubMed id 8125119)1, 2, 9 Yagi S.... Ra C. (1994)
    4. A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis. (PubMed id 15140034)1, 4 Kaneko S....Yoshie H. (2004)
    5. The E237G polymorphism of the high-affinity IgE receptor beta chain and asthma. (PubMed id 15562891)1, 4 Zhang X....Tan W.C. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Genetic factors and asthma in aluminum smelter workers. (PubMed id 14655898)1, 4 Arnaiz N.O....Checkoway H. (2003)
    8. A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. (PubMed id 12902495)1, 4 Hasegawa M....Ogawa H. (2003)
    9. Genetic polymorphisms in the promoter and 5' UTR region of the Fc alpha receptor (CD89) are not associated with a risk of IgA nephropathy. (PubMed id 11776381)1, 4 Narita I....Gejyo F. (2001)
    10. A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E. (PubMed id 1472946)1, 2 Padlan E.A. and Helm B.A. (1992)

    External Searches for FCER1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FCER1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2205 HGNC: 3609 AceView: FCER1A Ensembl:ENSG00000179639 euGenes: HUgn2205
    ECgene: FCER1A Kegg: 2205 H-InvDB: FCER1A

    Other Databases showing FCER1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FCER1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCER1A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FCER1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FCER1A gene:
    Search GeneIP for patents involving FCER1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FCER1A gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of FCER1A
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FCER1A (Fc epsilon RI alpha)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for FCER1A (Fc epsilon RI alpha)  
     Browse OriGene Antibodies   OriGene shRNA RFP for FCER1A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FCER1A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCER1A  
     OriGene Protein Over-expression Lysate for FCER1A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FCER1A   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCER1A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCER1A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCER1A   OriGene Custom Protein Services for FCER1A  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCER1A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCER1A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCER1A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCER1A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCER1A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCER1A
     GenScript Custom Purified and Recombinant Proteins Services for FCER1A GenScript cDNA clones with any tag delivered in your preferred vector for FCER1A
     GenScript Custom Assay Services for FCER1A GenScript Custom Superior Antibodies Services for FCER1A
     GenScript Custom overexpressing Cell Line Services for FCER1A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FCER1A promoter
     Search Chromatin IP Primers for FCER1A
     RT2 qPCR Primer Assay in human, mouse, rat FCER1A
     GNC Network for FCER1A
     SABiosciences PCR Arrays including human, mouse, rat FCER1A
     Search Tocris compounds for FCER1A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FCER1A antibodies
     FCER1A proteins
     FCER1A lysates
     Search for Antibodies for FCER1A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FCER1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for FCER1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A
     SwitchGear 3'UTR luciferase reporter plasmids for FCER1A
     SwitchGear Promoter luciferase reporter plasmids for FCER1A
     ThermoFisher Antibodies for FCER1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER1A
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FCER1A gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4