Aliases for FCER1A Gene
Aliases for FCER1A Gene
External Ids for FCER1A Gene
- HGNC: 3609
- Entrez Gene: 2205
- Ensembl: ENSG00000179639
- OMIM: 147140
- UniProtKB: P12319
Previous HGNC Symbols for FCER1A Gene
- FCE1A
Previous GeneCards Identifiers for FCER1A Gene
- GC01P157051
- GC01P154991
- GC01P156037
- GC01P156476
- GC01P156072
- GC01P157526
- GC01P130616
Summaries for FCER1A Gene
-
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
GeneCards Summary for FCER1A Gene
FCER1A (Fc Fragment Of IgE Receptor Ia) is a Protein Coding gene. Diseases associated with FCER1A include Urticaria and Allergic Urticaria. Among its related pathways are Immune response Fc epsilon RI pathway and Immune System. GO annotations related to this gene include IgE binding and IgE receptor activity. An important paralog of this gene is FCRL2.
UniProtKB/Swiss-Prot for FCER1A Gene
-
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1A Gene
Genomics for FCER1A Gene
Regulatory Elements for FCER1A Gene
Enhancers for FCER1A Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FCER1A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCER1A gene promoter:
Regulatory Element Products
Genomic Location for FCER1A Gene
- Chromosome:
- 1
- Start:
- 159,283,888 bp from pter
- End:
- 159,308,224 bp from pter
- Size:
- 24,337 bases
- Orientation:
- Plus strand
Genomic View for FCER1A Gene
Genes around FCER1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.2 by Ensembl
- 1q23 by Entrez Gene
- 1q23 by HGNC
FCER1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCER1A Gene
Proteins for FCER1A Gene
-
Protein details for FCER1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12319-FCERA_HUMAN
- Recommended name:
- High affinity immunoglobulin epsilon receptor subunit alpha
- Protein Accession:
- P12319
Protein attributes for FCER1A Gene
- Size:
- 257 amino acids
- Molecular mass:
- 29596 Da
- Quaternary structure:
-
- Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
Protein Expression for FCER1A Gene
Post-translational modifications for FCER1A Gene
Other Protein References for FCER1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FCER1A
- R&D Systems Antibodies for FCER1A (Fc epsilon RI alpha)
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- Abcam antibodies for Fc epsilon RI
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- antibodies-online Antibodies for FCER1A: See all 118
- GeneTex FCER1A antibody for FCER1A
-
Custom Antibody ServicesProSci Antibodies for FCER1A
-
Santa Cruz Biotechnology (SCBT) Antibodies for FCER1A
Protein Products
- R&D Systems Proteins and Enzymes for FCER1A (Fc epsilon RI alpha)
-
OriGene Purified Proteins for FCER1A
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- antibodies-online Proteins for FCER1A: See all 12
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- Search GeneTex for Proteins for FCER1A
- Abcam proteins for Fc epsilon RI
Assay Products
- antibodies-online Kits for FCER1A: See all 5
No data available for DME Specific Peptides for FCER1A Gene
Domains & Families for FCER1A Gene
Gene Families for FCER1A Gene
Protein Domains for FCER1A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCER1A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P12319- Domain:
-
- Contains 2 Ig-like (immunoglobulin-like) domains.
Function for FCER1A Gene
Molecular function for FCER1A Gene
- GENATLAS Biochemistry:
- immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a homodimeric gamma subunit
- UniProtKB/Swiss-Prot Function:
- Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Phenotypes for FCER1A Gene
- MGI mutant phenotypes for FCER1A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FCER1A:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for FCER1A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCER1A gene
- Search ViGene Biosciences for FCER1A
CRISPR Products
-
OriGene CRISPR knockouts for FCER1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCER1A
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miRNA Products
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Clone Products
- OriGene clones in human for FCER1A
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Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FCER1A Gene
Localization for FCER1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCER1A Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 2 |
| extracellular | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
No data available for Gene Ontology (GO) - Cellular Components for FCER1A Gene
Pathways & Interactions for FCER1A Gene
More details on SuperPathways for FCER1A| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response Fc epsilon RI pathway | ||
| 2 | Immune System |
.52
|
|
| 3 | Allograft rejection |
.44
|
|
| 4 | Phospholipase D signaling pathway | ||
| 5 | Sphingolipid signaling pathway |
Pathways by source for FCER1A Gene
1 BioSystems pathway for FCER1A Gene
3 Reactome pathways for FCER1A Gene
4 KEGG pathways for FCER1A Gene
2 GeneGo (Thomson Reuters) pathways for FCER1A Gene
2 R&D Systems pathways for FCER1A Gene
5 Qiagen pathways for FCER1A Gene
Interacting Proteins for FCER1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001820 | serotonin secretion | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007257 | activation of JUN kinase activity | IEA | -- |
| GO:0043306 | positive regulation of mast cell degranulation | IEA | -- |
| GO:0045087 | innate immune response | TAS | -- |
No data available for SIGNOR curated interactions for FCER1A Gene
Drugs & Compounds for FCER1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Omalizumab | Approved, Investigational | Pharma | antibody, Target | 138 | ||
| Benzylpenicilloyl Polylysine | Approved | Pharma | binder, Target, agonist | 0 | ||
| Desloratadine | Approved, Investigational | Pharma | 69 | |||
| TNX-901 | Investigational | Pharma | Target | 0 | ||
| Mizolastine | Pharma | 1 |
Transcripts for FCER1A Gene
mRNA/cDNA for FCER1A Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (27) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCER1A Gene
CRISPR Products
-
OriGene CRISPR knockouts for FCER1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCER1A
- GenScript: Design CRISPR guide RNA sequences for FCER1A
miRNA Products
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Clone Products
- OriGene clones in human for FCER1A
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Flow Cytometry Products
Expression for FCER1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Bone Marrow
- NULL (Uncategorized)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FCER1A Gene
This gene is overexpressed in Whole Blood (x6.0), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.8).
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER1A Gene
SOURCE GeneReport for Unigene cluster for FCER1A Gene Hs.897
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for FCER1A
-
OriGene qPCR primer pairs and template standards for FCER1A
No data available for mRNA Expression by UniProt/SwissProt for FCER1A Gene
Orthologs for FCER1A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | FCER1A 35 |
|
||
| FCER1A 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | FCER1A 35 |
|
||
| FCER1A 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Fcer1a 35 |
|
||
| Fcer1a 16 |
|
||||
| Fcer1a 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | FCER1A 35 |
|
||
| FCER1A 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Fcer1a 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FCER1A 36 |
|
OneToOne |
- Species with no ortholog for FCER1A:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCER1A Gene
Paralogs for FCER1A Gene
(12) SIMAP similar genes for FCER1A Gene using alignment to 3 proteins:
Variants for FCER1A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2298804 | - | 159,304,102(+) | TGCCA(A/G)ATTTG | reference, missense | |
| rs2298805 | - | 159,304,153(+) | TGAGA(A/G)TGAAC | reference, missense | |
| rs2494250 | -- | 159,308,461(+) | AAGTA(C/G)AGTCC | downstream-variant-500B | |
| rs2494262 | -- | 159,283,882(+) | TTCCT(A/C)CATGC | upstream-variant-2KB | |
| rs2494263 | -- | 159,286,004(+) | aacca(A/G)catgg | intron-variant |
Residual Variation Intolerance Score:
56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.82;
47.73% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCER1A Gene
- Human Gene Mutation Database (HGMD)
- FCER1A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER1A Gene
Disorders for FCER1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| urticaria |
|
|
| allergic urticaria |
|
|
| physical urticaria |
|
|
| dermatographia |
|
|
| pleomorphic lipoma |
|
|
Search FCER1A in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FCER1A
No data available for UniProtKB/Swiss-Prot and Genatlas for FCER1A Gene
Publications for FCER1A Gene
- Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PMID: 8245459) Pang J. … Zhou L. (J. Immunol. 1993) 2 3 23 67
- FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PMID: 20141544) Niwa Y. … Nishiyama C. (Int. J. Immunogenet. 2010) 3 23
- Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha). (PMID: 18726713) Potaczek D.P. … Okumura K. (Immunol. Res. 2009) 3 23
- Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI. (PMID: 18179824) Hartman M.L. … Kinet J.P. (Mol. Immunol. 2008) 3 23
- Generation of canine-human Fc IgE chimeric antibodies for the determination of the canine IgE domain of interaction with Fc epsilon RI alpha. (PMID: 18187193) Hunter M.J. … Helm B.A. (Mol. Immunol. 2008) 3 23
Products for FCER1A Gene
- R&D Systems Antibodies for FCER1A (Fc epsilon RI alpha)
- R&D Systems Proteins and Enzymes for FCER1A (Fc epsilon RI alpha)
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- Abcam antibodies for Fc epsilon RI
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- Addgene plasmids for FCER1A
- antibodies-online Antibodies for FCER1A: See all 118
- antibodies-online Kits for FCER1A: See all 5
- antibodies-online Proteins for FCER1A: See all 12
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- GeneTex FCER1A antibody for FCER1A
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- ViGene Biosciences adenoviral particle packaged cDNA for FCER1A gene
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- ViGene Biosciences ready-to-package AAV shRNAs for FCER1A gene
- ViGene Biosciences ready-to-package AAV shRNAs for FCER1A gene
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Sources for FCER1A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon