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FCER1A Gene

protein-coding   GIFtS: 62
GCID: GC01P159259

Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha...


(Previous symbol: FCE1A)
  See FCER1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha
Polypeptide1 2
     Fc Epsilon RI Alpha-Chain2
FCE1A1 2 3     Fc IgE Receptor, Alpha Polypeptide2
IgE Fc Receptor Subunit Alpha2 3     High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit2
FcERI2 3     High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha2
Fc-Epsilon RI-Alpha2 3     Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide2

External Ids:    HGNC: 36091   Entrez Gene: 22052   Ensembl: ENSG000001796397   OMIM: 1471405   UniProtKB: P123193   

Export aliases for FCER1A gene to outside databases

Previous GC identifers: GC01P157051 GC01P154991 GC01P156037 GC01P156476 GC01P156072 GC01P157526 GC01P130616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCER1A Gene:
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more
high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine
that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta
subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. (provided by
RefSeq, Aug 2011)

GeneCards Summary for FCER1A Gene:
FCER1A (Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide) is a protein-coding gene. Diseases associated with FCER1A include mast-cell leukemia, and allergic asthma. GO annotations related to this gene include IgE receptor activity and IgE binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319
Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating
the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of
mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the
secretion of important lymphokines

Gene Wiki entry for FCER1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCER1A gene promoter:
         c-Fos   AP-1   Fra-1   FosB   NF-kappaB   C/EBPalpha   Cart-1   Sox9   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCER1A promoter sequence
   Search Chromatin IP Primers for FCER1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCER1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23

FCER1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159259:  view genomic region     (about GC identifiers)

Start:
159,259,504 bp from pter      End:
159,278,014 bp from pter
Size:
18,511 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319 (See protein sequence)
Recommended Name: High affinity immunoglobulin epsilon receptor subunit alpha precursor  
Size: 257 amino acids; 29596 Da
Subunit: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains
Selected PDB 3D structures from and Proteopedia for FCER1A (see all 10):
1ALS (3D)        1ALT (3D)        1F2Q (3D)        1F6A (3D)        1J86 (3D)        1J87 (3D)    

Explore the universe of human proteins at neXtProt for FCER1A: NX_P12319

Explore proteomics data for FCER1A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn46, Asn67, Asn75, Asn99, Asn160, Asn165, Asn191

  • See FCER1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001992.1  
    ENSEMBL proteins: 
     ENSP00000357097   ENSP00000357096  
    Reactome Protein details: P12319

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    Sino Biological Cell Lysate for FCER1A
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P12319

    ProtoNet protein and cluster: P12319

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    Find genes that share domains with FCER1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCERA_HUMAN, P12319
    Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating
    the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of
    mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the
    secretion of important lymphokines

         Genatlas biochemistry entry for FCER1A:
    immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain
    and a homodimeric gamma subunit

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019767IgE receptor activity IEA--
    GO:0019863IgE binding IEA--
         
    Find genes that share ontologies with FCER1A           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fcer1a):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with FCER1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FCER1A: Fcer1atm1Knt Fcer1atm1Ftl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCER1A
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    hsa-miR-4272 hsa-miR-526b hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidFCER1A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCERA_HUMAN, P12319: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface IDA1535625

    Find genes that share ontologies with FCER1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCER1A About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    Fc epsilon RI signaling pathway0.41
    2PI-3K cascade
    Fc epsilon receptor (FCERI) signaling0.64
    3GPCR Pathway
    NFAT in Immune Response0.58
    4PEDF Induced Signaling
    NFAT Signaling and Lymphocyte Interactions0.57
    5Akt Signaling
    Tec Kinases Signaling0.55


    Find genes that share SuperPaths with FCER1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FCER1A
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FCER1A
        NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling
    Fc-EpsilonRI Pathway
    NFAT in Immune Response
    Phagocytosis of Microbes

    2 GeneGo (Thomson Reuters) Pathways for FCER1A
        Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    1 BioSystems Pathway for FCER1A
        Fc-epsilon receptor I signaling in mast cells


    5 Reactome Pathways for FCER1A
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    Fc epsilon receptor (FCERI) signaling
    Role of LAT2/NTAL/LAB on calcium mobilization
    FCERI mediated Ca+2 mobilization


    2 Kegg Pathways  (Kegg details for FCER1A):
        Fc epsilon RI signaling pathway
    Asthma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FCER1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FCER1A

    4 Interacting proteins for FCER1A (P123193) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCER1GP302733I2D: score=2 
    ITIH2P198233I2D: score=1 
    MS4A2Q013623I2D: score=1 
    VAV1P154983I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0001812positive regulation of type I hypersensitivity IEA--
    GO:0001820serotonin secretion IEA--
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ----

    Find genes that share ontologies with FCER1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for FCER1A (FCERA)

    3 DrugBank Compounds for FCER1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzylpenicilloyl Polylysine-- 2642-55-9targetagonist7436456 17139284 11752352 17016423
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Omalizumab-- 242138-07-4target--17368811 15356552

    2 Novoseek inferred chemical compound relationships for FCER1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    omalizumab 62.1 1 15356552 (1)
    histamine 49.9 2 7685756 (1), 8618029 (1)



    Find genes that share compounds with FCER1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCER1A gene: 
    NM_002001.3  

    Unigene Cluster for FCER1A:

    Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
    Hs.897  [show with all ESTs]
    Unigene Representative Sequence: NM_002001
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368115(uc001ftq.3) ENST00000368114
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFCER1A 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat FCER1A

    Additional mRNA sequence: 

    BC005912.1 BC015195.1 J03605.1 X06948.1 

    2 DOTS entries:

    DT.307957  DT.92037574 

    Selected AceView cDNA sequences (see all 27):

    CA419024 J03605 X06948 NM_002001 BQ005218 BC005912 BC015185 AI676097 
    BG542554 BC015195 BM991911 BG542157 CA448745 BX110472 BQ573778 BF679057 
    AW612525 BF675157 BF678252 BG548515 AI685796 BF593204 BF677190 CD696486 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCER1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGGGAAC
    FCER1A Expression
    About this image


    FCER1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)
             Mast-like cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Prostate (Endocrine System)
    FCER1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCER1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.897
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FCER1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCER1A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcer1a1 , 5 Fc receptor, IgE, high affinity I, alpha polypeptide1, 5 70.87(n)1
    53.04(a)1
      1 (80.33 cM)5
    141251  NM_010184.21  NP_034314.21 
     1732212715 


    ENSEMBL Gene Tree for FCER1A (if available)
    TreeFam Gene Tree for FCER1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCER1A gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  
    FCRL42  FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCRL62  
    12 SIMAP similar genes for FCER1A using alignment to 3 protein entries:     FCERA_HUMAN (see all proteins):
    FCGR1A    FCGR1B    FCGR1C    FCRLB    FCGR2A    Fc-gamma receptor IIIB
    FCGR3A    DKFZp686L20250    FCRL4    FCGR3B    FCGR2C    FCGR2B

    Find genes that share paralogs with FCER1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCER1A (see all 494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120316561,2
    H--159251875(+) GGGCCA/GGTTCT 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs1484697141,2
    C--159251984(+) GAATG-/AGAAAA 1 -- us2k10--------
    rs109087031,2
    C,F,A--159252002(+) AGGTGG/ACAGAA 1 -- us2k111Minor allele frequency- A:0.45NA WA CSA EA 373
    rs168419751,2
    C,F--159252040(+) TTCCTG/TCAATT 1 -- us2k14Minor allele frequency- T:0.04NA WA 260
    rs121271021,2
    C,F--159252043(+) CTGCAA/GTTGCA 1 -- us2k14Minor allele frequency- G:0.08CSA WA NA 241
    rs1406627411,2
    C--159252205(+) TTTTGC/TAACAC 1 -- us2k10--------
    rs2013930321,2
    --159252265(+) CTAAA-/TTTTTT 1 -- us2k10--------
    rs1446262591,2
    --159252399(+) CAGGTA/GCTTCA 1 -- us2k10--------
    rs1904453661,2
    --159252426(+) GAATAC/TAACTG 1 -- us2k10--------
    rs1816844871,2
    --159252653(+) GAAGGA/TTATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCER1A (159259504 - 159278014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FCER1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv396n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): FCER1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCER1A
    DNA2.0 Custom Variant and Variant Library Synthesis for FCER1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147140    OMIM disorders: --

    5 diseases for FCER1A:    
    About MalaCards
    mast-cell leukemia    allergic asthma    aggressive periodontitis    urticaria
    allergic rhinitis

    4 diseases from the University of Copenhagen DISEASES database for FCER1A:
    Urticaria     Hypersensitivity reaction type I disease     Asthma     Atopic dermatitis

    Find genes that share disorders with FCER1A           About GenesLikeMe

    3 Novoseek inferred disease relationships for FCER1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    idiopathic urticaria 62.7 1 8618029 (1)
    allergy 28.2 3 18726713 (1), 8543773 (1)
    allergic rhinitis 26.7 1 8543773 (1)

    Genetic Association Database (GAD): FCER1A
    Human Genome Epidemiology (HuGE) Navigator: FCER1A (29 documents)

    Export disorders for FCER1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FCER1A gene, integrated from 10 sources (see all 153):
    (articles sorted by number of sources associating them with FCER1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PubMed id 8245459)1, 3, 9 Pang J....Zhou L. (J. Immunol. 1993)
    2. FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PubMed id 20141544)1, 4, 9 Niwa Y....Nishiyama C. (Int. J. Immunogenet. 2010)
    3. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PubMed id 11531339)1, 2, 9 Garman S.C.... Jardetzky T.S. (J. Mol. Biol. 2001)
    4. High-level expression of the truncated alpha chain of human high- affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PubMed id 8125119)1, 2, 9 Yagi S.... Ra C. (Eur. J. Biochem. 1994)
    5. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PubMed id 22075330)1, 4 Granada M....O'Connor G.T. (J. Allergy Clin. Immunol. 2012)
    6. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease. (PubMed id 20691829)1, 4 Anderson J.L....Carlquist J.F. (Am. Heart J. 2010)
    9. Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. (PubMed id 20028371)1, 4 Mahachie John J.M....Weidinger S. (Allergy 2010)
    10. An association between functional FceRIalpha polymorphisms and total serum IgE levels in patients with inflammatory bowel disease. (PubMed id 20163202)1, 4 Potaczek D.P....Nishiyama C. (Scand. J. Gastroenterol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2205 HGNC: 3609 AceView: FCER1A Ensembl:ENSG00000179639 euGenes: HUgn2205
    ECgene: FCER1A Kegg: 2205 H-InvDB: FCER1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FCER1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCER1A gene:
    Search GeneIP for patents involving FCER1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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