Aliases for FCER1A Gene
Aliases for FCER1A Gene
External Ids for FCER1A Gene
- HGNC: 3609
- Entrez Gene: 2205
- Ensembl: ENSG00000179639
- OMIM: 147140
- UniProtKB: P12319
Previous HGNC Symbols for FCER1A Gene
- FCE1A
Previous GeneCards Identifiers for FCER1A Gene
- GC01P157051
- GC01P154991
- GC01P156037
- GC01P156476
- GC01P156072
- GC01P157526
- GC01P130616
Summaries for FCER1A Gene
-
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
GeneCards Summary for FCER1A Gene
FCER1A (Fc Fragment Of IgE Receptor Ia) is a Protein Coding gene. Diseases associated with FCER1A include Allergic Urticaria and Dermatographia. Among its related pathways are PEDF Induced Signaling and Phospholipase D signaling pathway. GO annotations related to this gene include IgE binding and IgE receptor activity. An important paralog of this gene is FCGR3A.
UniProtKB/Swiss-Prot for FCER1A Gene
-
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1A Gene
Genomics for FCER1A Gene
Regulatory Elements for FCER1A Gene
Enhancers for FCER1A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G159141 | 1 | FANTOM5 Ensembl | 14.8 | -141.9 | -141900 | 0.8 | TBP MXI1 SREBF2 SIN3A REST EP300 POLR2H JUND POLR2A POLR3A | OR6K3 OR6N1 FCER1A CADM3 ACKR1 CADM3-AS1 OR6N2 OR10J5 AIM2 OR10J1 |
| GH01G159229 | 0.5 | ENCODE | 15.1 | -54.0 | -54009 | 1.1 | STAT1 GATA2 ZNF512 HNF4A REST | FCER1A CADM3-AS1 ACKR1 OR10J2P OR10J3 MPTX1 |
| GH01G159211 | 0.7 | Ensembl | 9.8 | -72.5 | -72488 | 0.4 | SCRT1 CTCF ZNF654 ARNT CEBPB TRIM22 REST CEBPG RAD21 ATF3 | CADM3 AIM2 OR10J2P FCER1A OR10J3 DUSP23 ACKR1 CADM3-AS1 MPTX1 |
| GH01G158972 | 0.5 | FANTOM5 | 9.5 | -310.9 | -310857 | 0.2 | CTCF SMC3 RAD21 | FCER1A OR6N1 OR6K3 OR10Z1 DUSP23 OR10R2 OR10X1 OR6N2 PYHIN1 OR6P1 |
| GH01G159427 | 0.5 | ENCODE | 9.4 | +144.9 | 144864 | 2.8 | JUND MNT FOS | OR10J3 FCER1A OR10J2P ENSG00000228560 OR10J4 OR10J9P |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCER1A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCER1A gene promoter:
Regulatory Element Products
Genomic Location for FCER1A Gene
- Chromosome:
- 1
- Start:
- 159,283,888 bp from pter
- End:
- 159,308,224 bp from pter
- Size:
- 24,337 bases
- Orientation:
- Plus strand
Genomic View for FCER1A Gene
Genes around FCER1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.2 by Ensembl
- 1q23.2 by Entrez Gene
- 1q23.2 by HGNC
FCER1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCER1A Gene
Proteins for FCER1A Gene
-
Protein details for FCER1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12319-FCERA_HUMAN
- Recommended name:
- High affinity immunoglobulin epsilon receptor subunit alpha
- Protein Accession:
- P12319
Protein attributes for FCER1A Gene
- Size:
- 257 amino acids
- Molecular mass:
- 29596 Da
- Quaternary structure:
-
- Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
Protein Expression for FCER1A Gene
Post-translational modifications for FCER1A Gene
Other Protein References for FCER1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Santa Cruz Biotechnology (SCBT) Antibodies for FCER1A
Protein Products
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-
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- antibodies-online Proteins for FCER1A: See all 12
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-
ProSci Proteins for FCER1A
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Abcam proteins for FCER1A
Assay Products
- antibodies-online Kits for FCER1A: See all 5
No data available for DME Specific Peptides for FCER1A Gene
Domains & Families for FCER1A Gene
Gene Families for FCER1A Gene
Protein Domains for FCER1A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCER1A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCER1A Gene
Function for FCER1A Gene
Molecular function for FCER1A Gene
- GENATLAS Biochemistry:
- immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a homodimeric gamma subunit
- UniProtKB/Swiss-Prot Function:
- Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019767 | IgE receptor activity | IEA | -- |
| GO:0019863 | IgE binding | IEA | -- |
Phenotypes for FCER1A Gene
- MGI mutant phenotypes for FCER1A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FCER1A:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased shRNA abundance (Z-score < -2)
- Decreased shRNA abundance
Animal Model Products
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-
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ViGene Biosciences lentiviral particle packaged cDNA for FCER1A gene
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CRISPR Products
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miRNA Products
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Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for FCER1A (Fc epsilon RI alpha)
Cell Line Products
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FCER1A Gene
Localization for FCER1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCER1A Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IEA | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IDA | 1535625 |
Pathways & Interactions for FCER1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response Fc epsilon RI pathway | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Allograft rejection |
.44
|
|
| 4 | Phospholipase D signaling pathway | ||
| 5 | Sphingolipid signaling pathway | ||
Pathways by source for FCER1A Gene
2 BioSystems pathways for FCER1A Gene
3 Reactome pathways for FCER1A Gene
4 KEGG pathways for FCER1A Gene
2 GeneGo (Thomson Reuters) pathways for FCER1A Gene
2 R&D Systems pathways for FCER1A Gene
5 Qiagen pathways for FCER1A Gene
Interacting Proteins for FCER1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001812 | positive regulation of type I hypersensitivity | IEA | -- |
| GO:0001820 | serotonin secretion | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
| GO:0007257 | activation of JUN kinase activity | IEA | -- |
No data available for SIGNOR curated interactions for FCER1A Gene
Drugs & Compounds for FCER1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Omalizumab | Approved, Investigational | Pharma | antibody, Target | 145 | ||
| Benzylpenicilloyl Polylysine | Approved | Pharma | binder, Target, agonist | 0 | ||
| Desloratadine | Approved, Investigational | Pharma | High affinity H1 antagonist; anti-inflammatory. | 70 | ||
| Xolair | Approved June 2003 | Pharma | 0 | |||
| TNX-901 | Investigational | Pharma | Target | 0 |
Transcripts for FCER1A Gene
mRNA/cDNA for FCER1A Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (27) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCER1A Gene
CRISPR Products
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OriGene CRISPR knockouts for FCER1A
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Santa Cruz Biotechnology (SCBT) CRISPR for FCER1A
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miRNA Products
- Search ViGene Biosciences for FCER1A
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FCER1A
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ViGene Biosciences ready-to-package AAV shRNAs for FCER1A gene
Clone Products
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OriGene ORF clones in human for FCER1A
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- Addgene plasmids for FCER1A
- VectorBuilder custom plasmid, inducible vectors for FCER1A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCER1A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for FCER1A (Fc epsilon RI alpha)
Expression for FCER1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Bone Marrow
- NULL (Uncategorized)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FCER1A Gene
This gene is overexpressed in Whole Blood (x6.0), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.8).
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER1A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FCER1A Gene:
FCER1ASOURCE GeneReport for Unigene cluster for FCER1A Gene:
Hs.897Evidence on tissue expression from TISSUES for FCER1A Gene
- Spleen(2.6)
- Lymph node(2.5)
- Skin(2.5)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for FCER1A
-
OriGene qPCR primer pairs for FCER1A
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER1A Gene
Orthologs for FCER1A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCER1A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCER1A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCER1A 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcer1a 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcer1a 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FCER1A 35 |
|
OneToOne |
- Species where no ortholog for FCER1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCER1A Gene
Paralogs for FCER1A Gene
(12) SIMAP similar genes for FCER1A Gene using alignment to 3 proteins:
Variants for FCER1A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020538 | -- | 159,288,572(+) | ATTCA(C/G)TTAAC | intron-variant | |
| rs1000093390 | -- | 159,300,396(+) | AACAA(A/T)CTGGT | intron-variant | |
| rs1000182507 | -- | 159,294,159(+) | AGTGT(A/G)GCCAT | intron-variant | |
| rs1000199925 | -- | 159,289,801(+) | AAGGG(G/T)GATGG | intron-variant | |
| rs1000224371 | -- | 159,287,431(+) | CCATC(A/G)GTCAT | intron-variant |
Residual Variation Intolerance Score:
56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.82;
47.73% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCER1A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FCER1A Gene
Disorders for FCER1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| allergic urticaria |
|
|
| dermatographia |
|
|
| physical urticaria |
|
|
| pleomorphic lipoma |
|
|
| urticaria |
|
|
Search FCER1A in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FCER1A
No data available for UniProtKB/Swiss-Prot and Genatlas for FCER1A Gene
Publications for FCER1A Gene
- FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PMID: 20141544) Niwa Y. … Nishiyama C. (Int. J. Immunogenet. 2010) 3 22 46 64
- The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PMID: 11531339) Garman S.C. … Jardetzky T.S. (J. Mol. Biol. 2001) 3 4 22 64
- High-level expression of the truncated alpha chain of human high- affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PMID: 8125119) Yagi S. … Ra C. (Eur. J. Biochem. 1994) 3 4 22 64
- Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PMID: 8245459) Pang J. … Zhou L. (J. Immunol. 1993) 2 3 22 64
- A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PMID: 22075330) Granada M. … O'Connor G.T. (J. Allergy Clin. Immunol. 2012) 3 46 64
Products for FCER1A Gene
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- antibodies-online Antibodies for FCER1A: See all 118
- antibodies-online Kits for FCER1A: See all 5
- antibodies-online Proteins for FCER1A: See all 12
- Search antibodies-online for peptides
- GeneTex FCER1A antibody for FCER1A
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- ViGene Biosciences adenoviral particle packaged cDNA for FCER1A gene
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- Santa Cruz Biotechnology (SCBT) CRISPR for FCER1A
- Custom Antibody ServicesProSci Antibodies for FCER1A
- ProSci Proteins for FCER1A
- Horizon Cell Lines for FCER1A
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCER1A
- VectorBuilder custom plasmid, inducible vectors for FCER1A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCER1A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCER1A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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