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Aliases for FCER1A Gene

Aliases for FCER1A Gene

  • Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide 2 3
  • IgE Fc Receptor Subunit Alpha 3 4
  • Fc-Epsilon RI-Alpha 3 4
  • FCERI 3 4
  • FCE1A 3 4
  • Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide 3
  • High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit 3
  • Fc IgE Receptor, Alpha Polypeptide 3
  • Fc Epsilon RI Alpha-Chain 3

External Ids for FCER1A Gene

Previous HGNC Symbols for FCER1A Gene

  • FCE1A

Previous GeneCards Identifiers for FCER1A Gene

  • GC01P157051
  • GC01P154991
  • GC01P156037
  • GC01P156476
  • GC01P156072
  • GC01P157526
  • GC01P130616

Summaries for FCER1A Gene

Entrez Gene Summary for FCER1A Gene

  • The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

GeneCards Summary for FCER1A Gene

FCER1A (Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide) is a Protein Coding gene. Diseases associated with FCER1A include allergic urticaria and dermatographia. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include IgE binding and IgE receptor activity. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCER1A Gene

  • Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines

Gene Wiki entry for FCER1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1A Gene

Genomics for FCER1A Gene

Regulatory Elements for FCER1A Gene

Genomic Location for FCER1A Gene

Chromosome:
1
Start:
159,283,888 bp from pter
End:
159,308,224 bp from pter
Size:
24,337 bases
Orientation:
Plus strand

Genomic View for FCER1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FCER1A Gene

Proteins for FCER1A Gene

  • Protein details for FCER1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12319-FCERA_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit alpha
    Protein Accession:
    P12319

    Protein attributes for FCER1A Gene

    Size:
    257 amino acids
    Molecular mass:
    29596 Da
    Quaternary structure:
    • Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains

    Three dimensional structures from OCA and Proteopedia for FCER1A Gene

neXtProt entry for FCER1A Gene

Proteomics data for FCER1A Gene at MOPED

Post-translational modifications for FCER1A Gene

  • Glycosylation at Asn 46, Asn 67, Asn 75, Asn 99, Asn 160, Asn 165, and Asn 191
  • Modification sites at PhosphoSitePlus

Other Protein References for FCER1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FCER1A (Fc epsilon RI alpha)

No data available for DME Specific Peptides for FCER1A Gene

Domains & Families for FCER1A Gene

Gene Families for FCER1A Gene

Protein Domains for FCER1A Gene

Suggested Antigen Peptide Sequences for FCER1A Gene

Graphical View of Domain Structure for InterPro Entry

P12319

UniProtKB/Swiss-Prot:

FCERA_HUMAN :
  • Contains 2 Ig-like (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCER1A: view

Function for FCER1A Gene

Molecular function for FCER1A Gene

GENATLAS Biochemistry:
immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a homodimeric gamma subunit
UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines

Gene Ontology (GO) - Molecular Function for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019767 IgE receptor activity IEA --
GO:0019863 IgE binding IEA --
genes like me logo Genes that share ontologies with FCER1A: view
genes like me logo Genes that share phenotypes with FCER1A: view

Animal Models for FCER1A Gene

MGI Knock Outs for FCER1A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCER1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for FCER1A Gene

Localization for FCER1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER1A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCER1A Gene COMPARTMENTS Subcellular localization image for FCER1A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 1535625
genes like me logo Genes that share ontologies with FCER1A: view

Pathways & Interactions for FCER1A Gene

genes like me logo Genes that share pathways with FCER1A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity --
GO:0001812 positive regulation of type I hypersensitivity IEA --
GO:0001820 serotonin secretion IEA --
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with FCER1A: view

No data available for SIGNOR curated interactions for FCER1A Gene

Drugs & Compounds for FCER1A Gene

(5) Drugs for FCER1A Gene - From: NovoSeek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omalizumab Approved, Investigational Pharma antibody, Target 133
Benzylpenicilloyl Polylysine Approved Pharma binder, Target, agonist 0
TNX-901 Investigational Pharma Target 0
R112 Pharma 0
histamine Pharma Full agonist, Agonist 852
genes like me logo Genes that share compounds with FCER1A: view

Transcripts for FCER1A Gene

mRNA/cDNA for FCER1A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCER1A Gene

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCER1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCER1A Gene

No ASD Table

Relevant External Links for FCER1A Gene

GeneLoc Exon Structure for
FCER1A
ECgene alternative splicing isoforms for
FCER1A

Expression for FCER1A Gene

mRNA expression in normal human tissues for FCER1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER1A Gene

This gene is overexpressed in Whole Blood (x6.0), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.8).

Protein differential expression in normal tissues from HIPED for FCER1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER1A Gene



SOURCE GeneReport for Unigene cluster for FCER1A Gene Hs.897

genes like me logo Genes that share expression patterns with FCER1A: view

Protein tissue co-expression partners for FCER1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FCER1A Gene

Orthologs for FCER1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCER1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCER1A 35
  • 74.7 (n)
  • 61.26 (a)
FCER1A 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCER1A 35
  • 71.35 (n)
  • 56.22 (a)
FCER1A 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcer1a 35
  • 70.87 (n)
  • 53.04 (a)
Fcer1a 16
Fcer1a 36
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FCER1A 35
  • 99.09 (n)
  • 98.83 (a)
FCER1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcer1a 35
  • 70.69 (n)
  • 50 (a)
oppossum
(Monodelphis domestica)
Mammalia FCER1A 36
  • 31 (a)
OneToOne
Species with no ortholog for FCER1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER1A Gene

ENSEMBL:
Gene Tree for FCER1A (if available)
TreeFam:
Gene Tree for FCER1A (if available)

Paralogs for FCER1A Gene

(12) SIMAP similar genes for FCER1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FCER1A: view

Variants for FCER1A Gene

Sequence variations from dbSNP and Humsavar for FCER1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2247584 -- 159,289,890(+) CTGTA(G/T)TAGCT intron-variant
rs2251746 -- 159,302,270(+) TATGA(C/T)ACAGA intron-variant
rs2252226 -- 159,306,363(+) CCTAC(C/T)AGACT intron-variant
rs2269718 -- 159,305,916(+) GCGTG(A/G)CTCTC intron-variant
rs2269719 -- 159,306,441(+) GGTGA(C/T)AGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCER1A Gene

Variant ID Type Subtype PubMed ID
dgv396n71 CNV Loss 21882294

Variation tolerance for FCER1A Gene

Residual Variation Intolerance Score: 55.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCER1A Gene

HapMap Linkage Disequilibrium report
FCER1A
Human Gene Mutation Database (HGMD)
FCER1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER1A Gene

Disorders for FCER1A Gene

MalaCards: The human disease database

(6) MalaCards diseases for FCER1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
allergic urticaria
dermatographia
  • dermatographic urticaria
physical urticaria
  • symptomatic dermographism
pleomorphic lipoma
  • lipoma pleomorphic
urticaria
- elite association

Relevant External Links for FCER1A

Genetic Association Database (GAD)
FCER1A
Human Genome Epidemiology (HuGE) Navigator
FCER1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCER1A
genes like me logo Genes that share disorders with FCER1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER1A Gene

Publications for FCER1A Gene

  1. Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab. (PMID: 17368811) Mirkina I. … Kricek F. (Immunol. Lett. 2007) 23 25 67
  2. Omalizumab-induced reductions in mast cell Fce psilon RI expression and function. (PMID: 15356552) Beck L.A. … Saini S. (J. Allergy Clin. Immunol. 2004) 23 25 67
  3. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PMID: 8245459) Pang J. … Zhou L. (J. Immunol. 1993) 2 23 67
  4. FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PMID: 20141544) Niwa Y. … Nishiyama C. (Int. J. Immunogenet. 2010) 23 67
  5. Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha). (PMID: 18726713) Potaczek D.P. … Okumura K. (Immunol. Res. 2009) 23 67

Products for FCER1A Gene

Sources for FCER1A Gene

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