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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FCER1A Gene

protein-coding   GIFtS: 63
GCID: GC01P159259

Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha...


(Previous symbol: FCE1A)
  23 related diseases
at
MalaCards
 

Aliases
for FCER1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide1 2     Fc Epsilon RI Alpha-Chain2
FCE1A1 2 3     Fc IgE Receptor, Alpha Polypeptide2
IgE Fc Receptor Subunit Alpha2 3     High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit2
FcERI2 3     High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha2
Fc-Epsilon RI-Alpha2 3     Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide2

External Ids:    HGNC: 36091   Entrez Gene: 22052   Ensembl: ENSG000001796397   OMIM: 1471405   UniProtKB: P123193   

Export aliases for FCER1A gene to outside databases

Previous GC identifers: GC01P157051 GC01P154991 GC01P156037 GC01P156476 GC01P156072 GC01P157526 GC01P130616


Summaries
for FCER1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FCER1A Gene:
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more
high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are
responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two
gamma subunits. The protein encoded by this gene represents the alpha subunit. (provided by RefSeq, Aug 2011)

GeneCards Summary for FCER1A Gene: 
FCER1A (Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide) is a protein-coding gene. Diseases associated with FCER1A include allergic asthma, and mast-cell leukemia, and among its related super-pathways are Immune response BCR pathway and Role of LAT2/NTAL/LAB on calcium mobilization. GO annotations related to this gene include IgE receptor activity and IgE binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319
Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the
allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators
(such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of
important lymphokines

Gene Wiki entry for FCER1A Gene


Genomic Views
for FCER1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FCER1A gene promoter:
         c-Fos   AP-1   Fra-1   FosB   NF-kappaB   C/EBPalpha   Cart-1   Sox9   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCER1A promoter sequence
   Search SABiosciences Chromatin IP Primers for FCER1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCER1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23

FCER1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159259:  view genomic region     (about GC identifiers)

Start:
 159,259,504 bp from pter      End:
 159,278,014 bp from pter
Size:
 18,511 bases      Orientation:
 plus strand

Proteins
for FCER1A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319 (See protein sequence)
Recommended Name: High affinity immunoglobulin epsilon receptor subunit alpha precursor  
Size: 257 amino acids; 29596 Da
Subunit: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains
Subcellular location: Cell membrane; Single-pass type I membrane protein
6/10 PDB 3D structures from and Proteopedia for FCER1A (see all 10):
1ALS (3D)        1ALT (3D)        1F2Q (3D)        1F6A (3D)        1J86 (3D)        1J87 (3D)    

Explore the universe of human proteins at neXtProt for FCER1A: NX_P12319

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12319

    • FCER1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001992.1  
    ENSEMBL proteins: 
     ENSP00000357097   ENSP00000357096  
    Reactome Protein details: P12319
    Human Recombinant Protein Products for FCER1A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCER1A (Fc epsilon RI alpha)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FCER1A
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for FCER1A
    Novus Biologicals FCER1A Proteins
    Novus Biologicals FCER1A Lysates
    Sino Biological Recombinant Protein for FCER1A
    Sino Biological Cell Lysate for FCER1A 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--

    FCER1A for ontologies           About GeneDecksing



    FCER1A Antibody Products: 
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    Abcam antibodies for FCER1A
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    ThermoFisher Antibody for FCER1A
    LSBio Antibodies in human, mouse, rat for FCER1A 

    Assay Products for FCER1A: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for FCER1A gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P12319

    ProtoNet protein and cluster: P12319

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    FCER1A for domains           About GeneDecksing


    Function
    for FCER1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCERA_HUMAN, P12319
    Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the
    allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators
    (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of
    important lymphokines

         Genatlas biochemistry entry for FCER1A:
    immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a
    homodimeric gamma subunit

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019767IgE receptor activity IEA--
    GO:0019863IgE binding IEA--
         
    FCER1A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fcer1a):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 

    FCER1A for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for FCER1A: Fcer1atm1Knt Fcer1atm1Ftl
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FCER1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FCER1A

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FCER1A
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FCER1A:
    hsa-miR-4272 hsa-miR-526b hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: FCER1A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FCER1A
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    Sirion Biotech Custom design and validation of potent shRNA sequences against FCER1A

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FCER1A
                         Customized adenovirus for potent knockdown of FCER1A

    Clone
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    OriGene clones in human, mouse for FCER1A (see all 6)
    OriGene ORF clones in mouse, rat for FCER1A
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    GenScript: all cDNA clones in your preferred vector: FCER1A (NM_002001)
    Sino Biological Human cDNA Clone for FCER1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCER1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER1A

    Cell Line
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    Search LifeMap BioReagents cell lines for FCER1A
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                         Customized inducible knockdown cell line services for FCER1A
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                         Customized inducible overexpressing cell line services for FCER1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A


    Pathways & Interactions
    for FCER1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FCER1A About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway0.45
    		Fc-epsilon receptor I signaling in mast cells0.33
    		Fc epsilon RI signaling pathway0.40
    2Fc epsilon receptor (FCERI) signaling
    		Fc epsilon receptor (FCERI) signaling0.69
    		Role of LAT2/NTAL/LAB on calcium mobilization0.69
    3FCERI mediated Ca+2 mobilization
    		FCERI mediated Ca+2 mobilization0.60
    		FCERI mediated MAPK activation0.60
    4Immune System
    		Immune System0.56
    		Innate Immune System0.50
    5Immune response NFAT in immune response
    		Immune response NFAT in immune response0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for FCER1A
        Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway

    1 R&D Systems Pathway for FCER1A
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FCER1A
        NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling
    Fc-EpsilonRI Pathway
    NFAT in Immune Response
    Phagocytosis of Microbes

    2 GeneGo (Thomson Reuters) Pathways for FCER1A
        Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    1 BioSystems Pathway for FCER1A
        Fc-epsilon receptor I signaling in mast cells


    5/7        Reactome Pathways for FCER1A (see all 7)
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    Fc epsilon receptor (FCERI) signaling
    Role of LAT2/NTAL/LAB on calcium mobilization
    FCERI mediated Ca+2 mobilization


    2         Kegg Pathways  (Kegg details for FCER1A):
        Fc epsilon RI signaling pathway
    Asthma


    FCER1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FCER1A

    4 Interacting proteins for FCER1A (P123193) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCER1GP302733I2D: score=2 
    ITIH2P198233I2D: score=1 
    MS4A2Q013623I2D: score=1 
    VAV1P154983I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0001812positive regulation of type I hypersensitivity IEA--
    GO:0001820serotonin secretion IEA--
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ----

    FCER1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for FCER1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FCER1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FCER1A (FCERA)

    3 DrugBank Compounds for FCER1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzylpenicilloyl Polylysine-- 2642-55-9targetagonist7436456 17139284 11752352 17016423
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Omalizumab-- 242138-07-4target--17368811 15356552

    2 Novoseek inferred chemical compound relationships for FCER1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    omalizumab 62.1 1 15356552 (1)
    histamine 49.9 2 7685756 (1), 8618029 (1)

    Search CenterWatch for drugs/clinical trials and news about FCER1A / FCERA

    Transcripts
    for FCER1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FCER1A gene: 
    NM_002001.3  

    Unigene Cluster for FCER1A:

    Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
    Hs.897  [show with all ESTs]
    Unigene Representative Sequence: NM_002001
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368115(uc001ftq.3) ENST00000368114
    miRNA
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    hsa-miR-4272 hsa-miR-526b hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: FCER1A 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCER1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCER1A

    Additional mRNA sequence: 

    BC005912.1 BC015195.1 J03605.1 X06948.1 

    2 DOTS entries:

    DT.307957  DT.92037574 

    24/27 AceView cDNA sequences (see all 27):

    NM_002001 J03605 BQ005218 BC015185 X06948 CA419024 BC005912 BX110472 
    BQ573778 BG542554 AI676097 BM991911 BF679057 BG542157 CA448745 BC015195 
    AW612525 BF678252 BG548515 BF675157 AI685796 BF593204 BF677190 CD696486 

    GeneLoc Exon Structure


    Expression
    for FCER1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FCER1A expression in normal human tissues (normalized intensities)      FCER1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGGGAAC
    FCER1A Expression
    About this image


    FCER1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mast-like cells (Generation of hematopoietic progenitor cells and mast cells)
             lung ; macrophages
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lung (Respiratory System)
             lung ; macrophages
     
     Heart (Cardiovascular System)
             heart muscle ; myocytes
     
     Breast
             breast ; myoepithelial cells

    Genevestigator expression for FCER1A

    SOURCE GeneReport for Unigene cluster: Hs.897
        SABiosciences Expression via Pathway-Focused PCR Arrays including FCER1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCER1A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A

    Orthologs
    for FCER1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FCER1A gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fcer1a1 , 5 Fc receptor, IgE, high affinity I, alpha polypeptide1, 5 71.01(n)1
    53.04(a)1    		   1 (80.33 cM)5
    141251  NM_010184.21  NP_034314.21 
     1732212715 
    chicken
    (Gallus gallus)    		 Aves FCRL26
    		 Fc receptor family member
    		 15(a)
    		 1 → many
    		 25(1587904-1591630)


    ENSEMBL Gene Tree for FCER1A (if available)
    TreeFam Gene Tree for FCER1A (if available)

    Paralogs
    for FCER1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FCER1A gene
    FCGR1B2  FCGR2B2  FCRLB2  FCGR3B2  FCRL22  FCRL12  FCRLA2  FCRL52  
    FCRL42  FCGR2A2  FCGR1A2  FCGR3A2  FCRL32  FCRL62  
    12 SIMAP similar genes for FCER1A using alignment to 3 protein entries:     FCERA_HUMAN (see all proteins):
    FCGR1A    FCGR1B    FCGR1C    FCRLB    FCGR2A    Fc-gamma receptor IIIB
    FCGR3A    DKFZp686L20250    FCRL4    FCGR3B    FCGR2C    FCGR2B

    FCER1A for paralogs           About GeneDecksing



    Genomic Variants
    for FCER1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/494 SNPs in FCER1A are shown (see all 494)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120316561,2
    		H--159251875(+) GGGCCA/GGTTCT 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs1484697141,2
    		C--159251984(+) GAATG-/AGAAAA 1 -- us2k10--------
    rs109087031,2
    		C,F,A--159252002(+) AGGTGG/ACAGAA 1 -- us2k111Minor allele frequency- A:0.45NA WA CSA EA 373
    rs168419751,2
    		C,F--159252040(+) TTCCTG/TCAATT 1 -- us2k14Minor allele frequency- T:0.04NA WA 260
    rs121271021,2
    		C,F--159252043(+) CTGCAA/GTTGCA 1 -- us2k14Minor allele frequency- G:0.08CSA WA NA 241
    rs1406627411,2
    		C--159252205(+) TTTTGC/TAACAC 1 -- us2k10--------
    rs2013930321,2
    		--159252265(+) CTAAA-/TTTTTT 1 -- us2k10--------
    rs1446262591,2
    		--159252399(+) CAGGTA/GCTTCA 1 -- us2k10--------
    rs1904453661,2
    		--159252426(+) GAATAC/TAACTG 1 -- us2k10--------
    rs1816844871,2
    		--159252653(+) GAAGGA/TTATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FCER1A (159259504 - 159278014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FCER1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv396n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): FCER1A
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCER1A
    DNA2.0 Custom Variant and Variant Library Synthesis for FCER1A

    Disorders / Diseases
    for FCER1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FCER1A for disorders           About GeneDecksing

    OMIM gene information: 147140    OMIM disorders: --

    20/23 diseases for FCER1A (see all 23):    About MalaCards
    allergic asthma    mast-cell leukemia    urticaria    aggressive periodontitis
    allergic rhinitis    venous thromboembolism    wegener's granulomatosis    atopic dermatitis
    rhinitis    eczema    thromboembolism    vasculitis
    bronchiolitis    periodontitis    dermatitis    meningioma
    asthma    inflammatory bowel disease    hepatitis b    t-cell leukemia

    4 diseases from the University of Copenhagen DISEASES database for FCER1A:
    Urticaria     Hypersensitivity reaction type I disease     Asthma     Atopic dermatitis

    3 Novoseek inferred disease relationships for FCER1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    idiopathic urticaria 62.7 1 8618029 (1)
    allergy 28.2 3 18726713 (1), 8543773 (1)
    allergic rhinitis 26.7 1 8543773 (1)

    Genetic Association Database (GAD): FCER1A
    Human Genome Epidemiology (HuGE) Navigator: FCER1A (29 documents)

    Export disorders for FCER1A gene to outside databases

    Publications
    for FCER1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FCER1A gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with FCER1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PubMed id 8245459)1, 3, 9 Pang J....Zhou L. (1993)
    2. FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PubMed id 20141544)1, 4, 9 Niwa Y....Nishiyama C. (2010)
    3. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PubMed id 11531339)1, 2, 9 Garman S.C....Jardetzky T.S. (2001)
    4. High-level expression of the truncated alpha chain of human high- affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PubMed id 8125119)1, 2, 9 Yagi S.... Ra C. (1994)
    5. A genome-wide association study of plasma total IgE co ncentrations in the Framingham Heart Study. (PubMed id 22075330)1, 4 Granada M....O'Connor G.T. (2012)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Joint effects of common genetic variants from multipl e genes and pathways on the risk of premature coronary artery disease. (PubMed id 20691829)1, 4 Anderson J.L....Carlquist J.F. (2010)
    9. An association between functional FceRIalpha polymorp hisms and total serum IgE levels in patients with inflammatory bowel disease. (PubMed id 20163202)1, 4 Potaczek D.P....Nishiyama C. (2010)
    10. Single nucleotide polymorphisms in inflammation-relat ed genes are associated with venous thromboembolism. (PubMed id 20603037)1, 4 Beckers M.M....Biesma D.H. (2010)

    External Searches for FCER1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing FCER1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2205 HGNC: 3609 AceView: FCER1A Ensembl:ENSG00000179639 euGenes: HUgn2205
    ECgene: FCER1A Kegg: 2205 H-InvDB: FCER1A

    Other Databases showing FCER1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FCER1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FCER1A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FCER1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FCER1A gene:
    Search GeneIP for patents involving FCER1A

    GeneCards and IP:
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    About This Section

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