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FCER1A Gene

protein-coding GIFtS: 62
GCID: GC01P159259

Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha...

(Previous symbol: FCE1A)

Pneumococci & Pneumococcal Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide¹ ²		Fc Epsilon RI Alpha-Chain²
FCE1A¹ ² ³		Fc IgE Receptor, Alpha Polypeptide²
IgE Fc Receptor Subunit Alpha² ³		High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit²
FcERI² ³		High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha²
Fc-Epsilon RI-Alpha² ³		Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide²

External Ids:	HGNC: 3609¹	Entrez Gene: 2205²	Ensembl: ENSG00000179639⁷	OMIM: 147140⁵	UniProtKB: P12319³

Export aliases for FCER1A gene to outside databases

Previous GC identifers: GC01P157051 GC01P154991 GC01P156037 GC01P156476 GC01P156072 GC01P157526 GC01P130616

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FCER1A Gene:

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more

high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine

that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta

subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. (provided by

RefSeq, Aug 2011)

GeneCards Summary for FCER1A Gene:

FCER1A (Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide) is a protein-coding gene. Diseases associated with FCER1A include mast-cell leukemia, and allergic asthma. GO annotations related to this gene include IgE receptor activity and IgE binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319

Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating

the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of

mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the

secretion of important lymphokines

Gene Wiki entry for FCER1A Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NC_018912.2 NT_004487.20

Regulatory elements:

Regulatory transcription factor binding sites in the FCER1A gene promoter:
c-Fos AP-1 Fra-1 FosB NF-kappaB C/EBPalpha Cart-1 Sox9 c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FCER1A promoter sequence

Search Chromatin IP Primers for FCER1A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCER1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q23

FCER1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER1A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P159259: view genomic region (about GC identifiers)

Start:	159,259,504 bp from pter	End:	159,278,014 bp from pter
Size:	18,511 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319 (See protein sequence)

Recommended Name: High affinity immunoglobulin epsilon receptor subunit alpha precursor

Size: 257 amino acids; 29596 Da

Subunit: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains

Selected PDB 3D structures from and Proteopedia for FCER1A (see all 10):

1ALS (3D)

1ALT (3D)

1F2Q (3D)

1F6A (3D)

1J86 (3D)

1J87 (3D)

Explore the universe of human proteins at neXtProt for FCER1A: NX_P12319

Explore proteomics data for FCER1A at MOPED

Post-translational modifications:

Glycosylation² at Asn46, Asn67, Asn75, Asn99, Asn160, Asn165, Asn191

See FCER1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001992.1

ENSEMBL proteins:

ENSP00000357097 ENSP00000357096

Reactome Protein details: P12319

FCER1A Human Recombinant Protein Products:

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	Browse Proteins at Cloud-Clone Corp.

FCER1A Antibody Products:

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	Novus Biologicals FCER1A Antibodies
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	LSBio Antibodies in human, mouse, rat for FCER1A

FCER1A Assay Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

4 InterPro protein domains:

IPR003598 Ig_sub2

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P12319

ProtoNet protein and cluster: P12319

1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: FCERA_HUMAN, P12319

Similarity: Contains 2 Ig-like (immunoglobulin-like) domains

FCER1A for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: FCERA_HUMAN, P12319

Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating

the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of

mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the

secretion of important lymphokines

Genatlas biochemistry entry for FCER1A:

immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain

and a homodimeric gamma subunit

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0019767	IgE receptor activity	IEA	--
GO:0019863	IgE binding	IEA	--

FCER1A for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fcer1a):

cardiovascular system

hematopoietic system

homeostasis/metabolism

immune system

FCER1A for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for FCER1A: Fcer1a^tm1Knt Fcer1a^tm1Ftl

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCER1A

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCER1A

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCER1A

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCER1A

miRNA Products:		Block miRNA regulation of human, mouse, rat FCER1A using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate FCER1A:
		hsa-miR-4272 hsa-miR-526b hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: FCER1A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for FCER1A
		Predesigned siRNA for gene silencing in human, mouse, rat FCER1A

Gene Editing
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		GenScript: all cDNA clones in your preferred vector: FCER1A (NM_002001)
		Sino Biological Human cDNA Clone for FCER1A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCER1A
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FCER1A
		Browse ESI BIO Cell Lines and PureStem Progenitors for FCER1A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

FCERA_HUMAN, P12319: Cell membrane; Single-pass type I membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
endoplasmic reticulum	1
extracellular	1
mitochondrion	1
peroxisome	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	IEA	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	IDA	1535625

FCER1A for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FCER1A About (see all 10)

See pathways by source

SuperPath

Contained pathways About

Immune response Fc epsilon RI pathway

	Immune response Fc epsilon RI pathway	0.43			Fc-epsilon receptor I signaling in mast cells	0.34
	Fc epsilon RI signaling pathway	0.41

PI-3K cascade

Fc epsilon receptor (FCERI) signaling

0.64

GPCR Pathway

NFAT in Immune Response

0.58

PEDF Induced Signaling

NFAT Signaling and Lymphocyte Interactions

0.57

Akt Signaling

Tec Kinases Signaling

0.55

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for FCER1A

IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types

5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FCER1A

	NFAT Signaling and Lymphocyte Interactions
	Tec Kinases Signaling
	Fc-EpsilonRI Pathway
	NFAT in Immune Response
	Phagocytosis of Microbes

2 GeneGo (Thomson Reuters) Pathways for FCER1A

	Immune response Fc epsilon RI pathway
	Immune response NFAT in immune response

1 BioSystems Pathway for FCER1A

Fc-epsilon receptor I signaling in mast cells

5 Reactome Pathways for FCER1A

	FCERI mediated MAPK activation
	FCERI mediated NF-kB activation
	Fc epsilon receptor (FCERI) signaling
	Role of LAT2/NTAL/LAB on calcium mobilization
	FCERI mediated Ca+2 mobilization

2 Kegg Pathways (Kegg details for FCER1A):

	Fc epsilon RI signaling pathway
	Asthma

FCER1A for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including FCER1A:

Cell Surface Markers in human mouse rat

Antigen Presenting Cells in human mouse rat

Allergy & Asthma in human mouse rat

Interactions:

GeneGlobe Interaction Network for FCER1A

4 Interacting proteins for FCER1A (P12319³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FCER1G	P30273³	I2D: score=2
ITIH2	P19823³	I2D: score=1
MS4A2	Q01362³	I2D: score=1
VAV1	P15498³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	--	--
GO:0001812	positive regulation of type I hypersensitivity	IEA	--
GO:0001820	serotonin secretion	IEA	--
GO:0007165	signal transduction	--	--
GO:0007166	cell surface receptor signaling pathway	--	--

FCER1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for FCER1A (FCERA)

3 DrugBank Compounds for FCER1A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Benzylpenicilloyl Polylysine	--	2642-55-9	target	agonist	7436456 17139284 11752352 17016423
Alpha-D-Mannose	--	3458-28-4	target	--	17139284 17016423
Omalizumab	--	242138-07-4	target	--	17368811 15356552

2 Novoseek inferred chemical compound relationships for FCER1A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
omalizumab	62.1	1	15356552 (1)
histamine	49.9	2	7685756 (1), 8618029 (1)

FCER1A for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FCER1A gene:

NM_002001.3

Unigene Cluster for FCER1A:

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

Hs.897 [show with all ESTs]

Unigene Representative Sequence: NM_002001

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368115(uc001ftq.3) ENST00000368114

miRNA Products:		Block miRNA regulation of human, mouse, rat FCER1A using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate FCER1A:
		hsa-miR-4272 hsa-miR-526b hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: FCER1A 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat FCER1A

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		GenScript: all cDNA clones in your preferred vector: FCER1A (NM_002001)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCER1A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCER1A

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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat FCER1A
		QuantiTect SYBR Green Assays in human, mouse, rat FCER1A
		QuantiFast Probe-based Assays in human, mouse, rat FCER1A

Additional mRNA sequence:

BC005912.1 BC015195.1 J03605.1 X06948.1

2 DOTS entries:

DT.307957 DT.92037574

Selected AceView cDNA sequences (see all 27):

CA419024 J03605 X06948 NM_002001 BQ005218 BC005912 BC015185 AI676097

BG542554 BC015195 BM991911 BG542157 CA448745 BX110472 BQ573778 BF679057

AW612525 BF675157 BF678252 BG548515 AI685796 BF593204 BF677190 CD696486

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FCER1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAATGGGAAC

About this image

FCER1A expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


NULL (Uncategorized)
Mast-like cells

Bone (Muscoskeletal System)
Bone Marrow

Blood (Hematopoietic System)
Plasmacytoid Dendritic cells Peripheral Blood

Prostate (Endocrine System)

FCER1A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

FCER1A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.897

Pathway & Disease-focused RT² Profiler PCR Arrays including FCER1A:

Cell Surface Markers in human mouse rat

Antigen Presenting Cells in human mouse rat

Allergy & Asthma in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for FCER1A OriGene qSTAR qPCR primer pairs in human, mouse for FCER1A
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat FCER1A
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		QuantiFast Probe-based Assays in human, mouse, rat FCER1A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCER1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for FCER1A gene from Selected species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fcer1a^{1 , 5}	Fc receptor, IgE, high affinity I, alpha polypeptide^{1, 5}	70.87(n)¹ 53.04(a)¹		1 (80.33 cM)⁵ 14125¹ NM_010184.2¹ NP_034314.2¹ 173221271⁵

ENSEMBL Gene Tree for FCER1A (if available)
TreeFam Gene Tree for FCER1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for FCER1A gene

FCGR1B² FCGR2B² FCRLB² FCGR3B² FCRL2² FCRL1² FCRLA² FCRL5²

FCRL4² FCGR2A² FCGR1A² FCGR3A² FCRL3² FCRL6²

12 SIMAP similar genes for FCER1A using alignment to 3 protein entries: FCERA_HUMAN (see all proteins):

FCGR1A FCGR1B FCGR1C FCRLB FCGR2A Fc-gamma receptor IIIB

FCGR3A DKFZp686L20250 FCRL4 FCGR3B FCGR2C FCGR2B

FCER1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12031656^1,2	H	--	159251875(+)	`GGGCCA/GGTTCT`	1	--	us2k¹		4		NS EA	412
rs148469714^1,2	C	--	159251984(+)	`GAATG-/AGAAAA`	1	--	us2k¹		0	--	--	--	--
rs10908703^1,2	C,F,A	--	159252002(+)	`AGGTGG/ACAGAA`	1	--	us2k¹		11		NA WA CSA EA	373
rs16841975^1,2	C,F	--	159252040(+)	`TTCCTG/TCAATT`	1	--	us2k¹		4		NA WA	260
rs12127102^1,2	C,F	--	159252043(+)	`CTGCAA/GTTGCA`	1	--	us2k¹		4		CSA WA NA	241
rs140662741^1,2	C	--	159252205(+)	`TTTTGC/TAACAC`	1	--	us2k¹		0	--	--	--	--
rs201393032^1,2		--	159252265(+)	`CTAAA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs144626259^1,2		--	159252399(+)	`CAGGTA/GCTTCA`	1	--	us2k¹		0	--	--	--	--
rs190445366^1,2		--	159252426(+)	`GAATAC/TAACTG`	1	--	us2k¹		0	--	--	--	--
rs181684487^1,2		--	159252653(+)	`GAAGGA/TTATAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FCER1A (159259504 - 159278014 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for FCER1A: About this table

Variant ID	Type	Subtype	PubMed ID
dgv396n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): FCER1A

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing FCER1A

DNA2.0 Custom Variant and Variant Library Synthesis for FCER1A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147140 OMIM disorders: --

Selected diseases for FCER1A (see all 27):
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mast-cell leukemia allergic asthma urticaria aggressive periodontitis

allergic rhinitis venous thromboembolism wegener's granulomatosis rhinitis

atopic dermatitis thromboembolism vasculitis bronchiolitis

periodontitis childhood leukemia asthma dermatitis

t-cell leukemia meningioma inflammatory bowel disease coronary artery disease

4 diseases from the University of Copenhagen DISEASES database for FCER1A:

Urticaria Hypersensitivity reaction type I disease Asthma Atopic dermatitis

FCER1A for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

3 Novoseek inferred disease relationships for FCER1A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
idiopathic urticaria	62.7	1	8618029 (1)
allergy	28.2	3	18726713 (1), 8543773 (1)
allergic rhinitis	26.7	1	8543773 (1)

Genetic Association Database (GAD): FCER1A
Human Genome Epidemiology (HuGE) Navigator: FCER1A (29 documents)

Export disorders for FCER1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FCER1A gene, integrated from 10 sources (see all 153):
(articles sorted by number of sources associating them with FCER1A)

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Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PubMed id 8245459)^{1, 3, 9} Pang J....Zhou L. (J. Immunol. 1993)
FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PubMed id 20141544)^{1, 4, 9} Niwa Y....Nishiyama C. (Int. J. Immunogenet. 2010)
The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PubMed id 11531339)^{1, 2, 9} Garman S.C.... Jardetzky T.S. (J. Mol. Biol. 2001)
High-level expression of the truncated alpha chain of human high- affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PubMed id 8125119)^{1, 2, 9} Yagi S.... Ra C. (Eur. J. Biochem. 1994)
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PubMed id 22075330)^{1, 4} Granada M....O'Connor G.T. (J. Allergy Clin. Immunol. 2012)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease. (PubMed id 20691829)^{1, 4} Anderson J.L....Carlquist J.F. (Am. Heart J. 2010)
Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. (PubMed id 20028371)^{1, 4} Mahachie John J.M....Weidinger S. (Allergy 2010)
An association between functional FceRIalpha polymorphisms and total serum IgE levels in patients with inflammatory bowel disease. (PubMed id 20163202)^{1, 4} Potaczek D.P....Nishiyama C. (Scand. J. Gastroenterol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2205	HGNC: 3609	AceView: FCER1A	Ensembl:ENSG00000179639	euGenes: HUgn2205
ECgene: FCER1A	Kegg: 2205	H-InvDB: FCER1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FCER1A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FCER1A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FCER1A gene:
Search GeneIP for patents involving FCER1A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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