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Aliases for FCER1A Gene

Aliases for FCER1A Gene

  • Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide 2 3
  • IgE Fc Receptor Subunit Alpha 3 4
  • Fc-Epsilon RI-Alpha 3 4
  • FCERI 3 4
  • FCE1A 3 4
  • Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide 3
  • High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit 3
  • High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha 3
  • Fc IgE Receptor, Alpha Polypeptide 3
  • Fc Epsilon RI Alpha-Chain 3

External Ids for FCER1A Gene

Previous Symbols for FCER1A Gene

  • FCE1A

Summaries for FCER1A Gene

Entrez Gene Summary for FCER1A Gene

  • The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

GeneCards Summary for FCER1A Gene

FCER1A (Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide) is a Protein Coding gene. Diseases associated with FCER1A include mast-cell leukemia and allergic asthma. Among its related pathways are PI-3K cascade and Akt Signaling. GO annotations related to this gene include IgE binding and IgE receptor activity. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCER1A Gene

  • Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines

Gene Wiki entry for FCER1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1A Gene

Genomics for FCER1A Gene

Genomic Location for FCER1A Gene

Start:
159,283,888 bp from pter
End:
159,308,224 bp from pter
Size:
24,337 bases
Orientation:
Plus strand

Genomic View for FCER1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCER1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER1A Gene

Regulatory Elements for FCER1A Gene

Proteins for FCER1A Gene

  • Protein details for FCER1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12319-FCERA_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit alpha
    Protein Accession:
    P12319
    Secondary Accessions:

    Protein attributes for FCER1A Gene

    Size:
    257 amino acids
    Molecular mass:
    29596 Da
    Quaternary structure:
    • Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains

    Three dimensional structures from OCA and Proteopedia for FCER1A Gene

neXtProt entry for FCER1A Gene

Proteomics data for FCER1A Gene at MOPED

Post-translational modifications for FCER1A Gene

  • Glycosylation at Asn46, Asn67, Asn75, Asn99, Asn160, Asn165, and Asn191

Other Protein References for FCER1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FCER1A Gene

Domains for FCER1A Gene

Gene Families for FCER1A Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FCER1A Gene

Suggested Antigen Peptide Sequences for FCER1A Gene

Graphical View of Domain Structure for InterPro Entry

P12319

UniProtKB/Swiss-Prot:

FCERA_HUMAN
Domain:
  • Contains 2 Ig-like (immunoglobulin-like) domains.:
    • P12319
genes like me logo Genes that share domains with FCER1A: view

Function for FCER1A Gene

Molecular function for FCER1A Gene

GENATLAS Biochemistry: immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a homodimeric gamma subunit
UniProtKB/Swiss-Prot Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines

Gene Ontology (GO) - Molecular Function for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019767 IgE receptor activity IEA --
GO:0019863 IgE binding IEA --
genes like me logo Genes that share ontologies with FCER1A: view
genes like me logo Genes that share phenotypes with FCER1A: view

Animal Models for FCER1A Gene

MGI Knock Outs for FCER1A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FCER1A Gene

Localization for FCER1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER1A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCER1A Gene COMPARTMENTS Subcellular localization image for FCER1A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 1535625
genes like me logo Genes that share ontologies with FCER1A: view

Pathways for FCER1A Gene

genes like me logo Genes that share pathways with FCER1A: view

Pathways by source for FCER1A Gene

Gene Ontology (GO) - Biological Process for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity --
GO:0001812 positive regulation of type I hypersensitivity IEA --
GO:0001820 serotonin secretion IEA --
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with FCER1A: view

Compounds for FCER1A Gene

(3) Drugbank Compounds for FCER1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
Benzylpenicilloyl Polylysine
2642-55-9 target agonist
Omalizumab
242138-07-4 target

(2) Novoseek inferred chemical compound relationships for FCER1A Gene

Compound -log(P) Hits PubMed IDs
omalizumab 62.1 1
histamine 49.9 2
genes like me logo Genes that share compounds with FCER1A: view

Transcripts for FCER1A Gene

mRNA/cDNA for FCER1A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCER1A Gene

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FCER1A Gene

No ASD Table

Relevant External Links for FCER1A Gene

GeneLoc Exon Structure for
FCER1A
ECgene alternative splicing isoforms for
FCER1A

Expression for FCER1A Gene

mRNA expression in normal human tissues for FCER1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER1A Gene

This gene is overexpressed in Whole Blood (6.0), Skin - Sun Exposed (Lower leg) (5.9), and Skin - Not Sun Exposed (Suprapubic) (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FCER1A Gene

SOURCE GeneReport for Unigene cluster for FCER1A Gene Hs.897

genes like me logo Genes that share expressions with FCER1A: view

No data available for mRNA Expression by UniProt/SwissProt for FCER1A Gene

Orthologs for FCER1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCER1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCER1A 35
  • 99.09 (n)
  • 98.83 (a)
FCER1A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCER1A 35
  • 74.7 (n)
  • 61.26 (a)
FCER1A 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCER1A 35
  • 71.35 (n)
  • 56.22 (a)
FCER1A 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcer1a 35
  • 70.87 (n)
  • 53.04 (a)
Fcer1a 16
Fcer1a 36
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCER1A 36
  • 31 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcer1a 35
  • 70.69 (n)
  • 50 (a)
Species with no ortholog for FCER1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER1A Gene

ENSEMBL:
Gene Tree for FCER1A (if available)
TreeFam:
Gene Tree for FCER1A (if available)

Paralogs for FCER1A Gene

Selected SIMAP similar genes for FCER1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FCER1A: view

Variants for FCER1A Gene

Sequence variations from dbSNP and Humsavar for FCER1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2247584 -- 159,289,890(+) CTGTA(G/T)TAGCT intron-variant
rs2251746 -- 159,302,270(+) TATGA(C/T)ACAGA intron-variant
rs2252226 -- 159,306,363(+) CCTAC(C/T)AGACT intron-variant
rs2269718 -- 159,305,916(+) GCGTG(A/G)CTCTC intron-variant
rs2269719 -- 159,306,441(+) GGTGA(C/T)AGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCER1A Gene

Variant ID Type Subtype PubMed ID
dgv396n71 CNV Loss 21882294

Relevant External Links for FCER1A Gene

HapMap Linkage Disequilibrium report
FCER1A
Human Gene Mutation Database (HGMD)
FCER1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER1A Gene

Disorders for FCER1A Gene

(4) University of Copenhagen DISEASES for FCER1A Gene

(3) Novoseek inferred disease relationships for FCER1A Gene

Disease -log(P) Hits PubMed IDs
idiopathic urticaria 62.7 1
allergy 28.2 2
allergic rhinitis 26.7 1

Relevant External Links for FCER1A

Genetic Association Database (GAD)
FCER1A
Human Genome Epidemiology (HuGE) Navigator
FCER1A
genes like me logo Genes that share disorders with FCER1A: view

No data available for UniProtKB/Swiss-Prot for FCER1A Gene

Publications for FCER1A Gene

  1. High-level expression of the truncated alpha chain of human high- affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PMID: 8125119) Yagi S. … Ra C. (Eur. J. Biochem. 1994) 3 4 23
  2. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PMID: 8245459) Pang J. … Zhou L. (J. Immunol. 1993) 2 3 23
  3. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PMID: 11531339) Garman S.C. … Jardetzky T.S. (J. Mol. Biol. 2001) 3 4 23
  4. FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PMID: 20141544) Niwa Y. … Nishiyama C. (Int. J. Immunogenet. 2010) 3 23 48
  5. A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E. (PMID: 1472946) Padlan E.A. … Helm B.A. (Receptor 1992) 3 4

Products for FCER1A Gene

Sources for FCER1A Gene

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