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Aliases for FCAR Gene

Aliases for FCAR Gene

  • Fc Fragment Of IgA Receptor 2 3 5
  • Fc Fragment Of IgA, Receptor For 2 3
  • CD89 3 4
  • Immunoglobulin Alpha Fc Receptor 3
  • Fc Alpha Receptor 3
  • FCAR Variant 14 3
  • IgA Fc Receptor 4
  • CD89 Antigen 4
  • CTB-61M7.2 3
  • FcalphaRI 3

External Ids for FCAR Gene

Previous GeneCards Identifiers for FCAR Gene

  • GC19P056248
  • GC19P055810
  • GC19P060006
  • GC19P060077
  • GC19P055386
  • GC19P051708
  • GC19P054893
  • GC19P054902
  • GC19P054919
  • GC19P054938
  • GC19P054963

Summaries for FCAR Gene

Entrez Gene Summary for FCAR Gene

  • This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCAR Gene

FCAR (Fc Fragment Of IgA Receptor) is a Protein Coding gene. Diseases associated with FCAR include Iga Glomerulonephritis. Among its related pathways are Innate Immune System and Phagosome. GO annotations related to this gene include IgA binding. An important paralog of this gene is LILRB1.

UniProtKB/Swiss-Prot for FCAR Gene

  • Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Gene Wiki entry for FCAR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCAR Gene

Genomics for FCAR Gene

Regulatory Elements for FCAR Gene

Enhancers for FCAR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G054873 1.8 FANTOM5 Ensembl ENCODE 32.5 +2.1 2091 5.2 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF207 FCAR LILRA2 KIR2DS4 ZNF628 U2AF2 PRPF31 ZNF581 LENG8-AS1 LILRA1 NLRP2
GH19G054368 1.8 FANTOM5 Ensembl ENCODE dbSUPER 25.8 -501.3 -501258 8.9 HDGF PKNOX1 YY1 ZNF766 ZNF143 JUNB REST TBX21 MAFF ATF4 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
GH19G055320 1.5 FANTOM5 Ensembl ENCODE 20.1 +449.2 449233 5.7 PKNOX1 SCRT2 CREM CEBPB ELF1 ZNF592 ZNF579 SMARCA4 CEBPA IKZF1 FCAR TMEM150B FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 RPL28 TMEM238
GH19G054660 1.6 FANTOM5 Ensembl ENCODE 14.5 -211.8 -211797 4.2 HDGF ATF1 PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A GLI4 GLIS2 FOS LILRB4 FCAR LAIR1 LILRB1 KIR3DX1 LILRB2 KIR2DL3 LILRA5 LILRB3 LILRA1
GH19G054642 1.4 FANTOM5 Ensembl ENCODE 14.7 -230.2 -230193 2.6 HDAC1 ZNF335 EGR1 EGR2 SP3 ZBTB11 NFYC ELF4 ZEB2 ELF1 LILRA1 LAIR1 FCAR LILRB1 LILRB3 LILRB4 LILRA2 LILRB2 LILRA5 LAIR2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCAR on UCSC Golden Path with GeneCards custom track

Genomic Location for FCAR Gene

Chromosome:
19
Start:
54,874,093 bp from pter
End:
54,891,420 bp from pter
Size:
17,328 bases
Orientation:
Plus strand

Genomic View for FCAR Gene

Genes around FCAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FCAR Gene

  • Protein details for FCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24071-FCAR_HUMAN
    Recommended name:
    Immunoglobulin alpha Fc receptor
    Protein Accession:
    P24071
    Secondary Accessions:
    • Q13603
    • Q13604
    • Q15727
    • Q15728
    • Q1AJL7
    • Q1AJL8
    • Q1AJL9
    • Q53X38
    • Q53X39
    • Q92587
    • Q92588
    • Q92590
    • Q92592
    • Q92593
    • Q9UEK0

    Protein attributes for FCAR Gene

    Size:
    287 amino acids
    Molecular mass:
    32265 Da
    Quaternary structure:
    • Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.

    Three dimensional structures from OCA and Proteopedia for FCAR Gene

    Alternative splice isoforms for FCAR Gene

neXtProt entry for FCAR Gene

Post-translational modifications for FCAR Gene

  • Glycosylation at isoforms=2, 3, 4, 5, 6, 8, 9, 10, 1165, Asn79, Asn141, Asn177, isoforms=2, 4, 5, 7, 6, 8, 10, 11186, and isoforms=4, 5, 7, 10198
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for FCAR

Protein Products

  • Abcam proteins for FCAR

No data available for DME Specific Peptides for FCAR Gene

Domains & Families for FCAR Gene

Protein Domains for FCAR Gene

Suggested Antigen Peptide Sequences for FCAR Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCAR: view

No data available for UniProtKB/Swiss-Prot for FCAR Gene

Function for FCAR Gene

Molecular function for FCAR Gene

GENATLAS Biochemistry:
immunoglobulin A,Fc receptor expressed on granulocyte,monocyte,macrophage,T cell,B cell,complexing with a cytoplasmic homodimer gamma subunit with the immunoreceptor based inhibitory motif (ITIM),natural killer inhibitory receptor family
UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Gene Ontology (GO) - Molecular Function for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019862 IgA binding IEA --
genes like me logo Genes that share ontologies with FCAR: view

Phenotypes for FCAR Gene

genes like me logo Genes that share phenotypes with FCAR: view

Animal Model Products

CRISPR Products

miRNA for FCAR Gene

miRTarBase miRNAs that target FCAR

Clone Products

  • Applied Biological Materials Clones for FCAR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCAR Gene

Localization for FCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCAR Gene

Isoform A.1: Cell membrane; Single-pass type I membrane protein.
Isoform A.2: Cell membrane; Single-pass type I membrane protein.
Isoform A.3: Cell membrane; Single-pass type I membrane protein.
Isoform B: Secreted.
Isoform B-delta-S2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCAR gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2258698
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCAR: view

Pathways & Interactions for FCAR Gene

genes like me logo Genes that share pathways with FCAR: view

Pathways by source for FCAR Gene

3 Reactome pathways for FCAR Gene
2 KEGG pathways for FCAR Gene

Gene Ontology (GO) - Biological Process for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 10835685
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with FCAR: view

No data available for SIGNOR curated interactions for FCAR Gene

Drugs & Compounds for FCAR Gene

(3) Drugs for FCAR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FCAR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCAR: view

Transcripts for FCAR Gene

Unigene Clusters for FCAR Gene

Fc fragment of IgA, receptor for:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for FCAR

Alternative Splicing Database (ASD) splice patterns (SP) for FCAR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - - -

Relevant External Links for FCAR Gene

GeneLoc Exon Structure for
FCAR
ECgene alternative splicing isoforms for
FCAR

Expression for FCAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCAR Gene

This gene is overexpressed in Whole Blood (x46.8).

Protein differential expression in normal tissues from HIPED for FCAR Gene

This gene is overexpressed in Monocytes (44.2) and Neutrophil (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCAR Gene



Protein tissue co-expression partners for FCAR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCAR Gene:

FCAR

SOURCE GeneReport for Unigene cluster for FCAR Gene:

Hs.659872

mRNA Expression by UniProt/SwissProt for FCAR Gene:

P24071-FCAR_HUMAN
Tissue specificity: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.

Evidence on tissue expression from TISSUES for FCAR Gene

  • Blood(4.5)
  • Bone marrow(4.5)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FCAR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCAR Gene

Orthologs for FCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCAR 34
  • 98.21 (n)
PT-FCAR 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCAR 34 35
  • 72.84 (n)
rat
(Rattus norvegicus)
Mammalia Fcar 34
  • 68.01 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 4 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 9 (a)
OneToMany
Species where no ortholog for FCAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCAR Gene

ENSEMBL:
Gene Tree for FCAR (if available)
TreeFam:
Gene Tree for FCAR (if available)

Paralogs for FCAR Gene

(4) SIMAP similar genes for FCAR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FCAR: view

Variants for FCAR Gene

Sequence variations from dbSNP and Humsavar for FCAR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11666735 --
rs16986050 --
rs201322264 -- 54,872,817(+) AATAC(-/A)AAAAA upstream-variant-2KB
rs34625687 -- 54,879,677(+) TCACA(-/T)TTTTT intron-variant
rs72230191 -- 54,878,875(+) CTTGC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCAR Gene

Variant ID Type Subtype PubMed ID
dgv438n27 CNV gain 19166990
dgv6580n54 CNV gain 21841781
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv3644820 CNV loss 21293372
nsv428372 CNV gain+loss 18775914
nsv469656 CNV loss 16826518
nsv471706 CNV loss 15918152
nsv520644 CNV loss 19592680
nsv833880 CNV loss 17160897

Variation tolerance for FCAR Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCAR Gene

Human Gene Mutation Database (HGMD)
FCAR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAR Gene

Disorders for FCAR Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCAR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
iga glomerulonephritis
  • berger's iga or igg nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search FCAR in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCAR

Genetic Association Database (GAD)
FCAR
Human Genome Epidemiology (HuGE) Navigator
FCAR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCAR
genes like me logo Genes that share disorders with FCAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCAR Gene

Publications for FCAR Gene

  1. Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. (PMID: 17033823) Watanabe A. … Ra C. (Immunogenetics 2006) 3 22 46 64
  2. Are single nucleotide polymorphisms of the immunoglobulin A Fc receptor gene associated with allergic asthma? (PMID: 15564774) Jasek M. … KuA9nierczyk P. (Int. Arch. Allergy Immunol. 2004) 3 22 46 64
  3. IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. (PMID: 9367406) Toyabe S. … Abo T. (Clin. Exp. Immunol. 1997) 3 4 22 64
  4. Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. (PMID: 8666819) Patry C. … Monteiro R.C. (J. Immunol. 1996) 3 4 22 64
  5. Structure of the gene for the human myeloid IgA Fc receptor (CD89). (PMID: 7636188) de Wit T.P.M. … van de Winkel J.G.J. (J. Immunol. 1995) 3 4 22 64

Products for FCAR Gene

Sources for FCAR Gene

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