Aliases for FCAR Gene
Aliases for FCAR Gene
External Ids for FCAR Gene
- HGNC: 3608
- Entrez Gene: 2204
- Ensembl: ENSG00000186431
- OMIM: 147045
- UniProtKB: P24071
Previous GeneCards Identifiers for FCAR Gene
- GC19P056248
- GC19P055810
- GC19P060006
- GC19P060077
- GC19P055386
- GC19P051708
- GC19P054893
- GC19P054902
- GC19P054919
- GC19P054938
- GC19P054963
Summaries for FCAR Gene
-
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FCAR Gene
FCAR (Fc Fragment Of IgA Receptor) is a Protein Coding gene. Diseases associated with FCAR include Iga Glomerulonephritis. Among its related pathways are Innate Immune System and Phagosome. GO annotations related to this gene include IgA binding. An important paralog of this gene is LILRB1.
UniProtKB/Swiss-Prot for FCAR Gene
-
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCAR Gene
Genomics for FCAR Gene
Regulatory Elements for FCAR Gene
Enhancers for FCAR Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCAR on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FCAR gene promoter:
Regulatory Element Products
Genomic Location for FCAR Gene
- Chromosome:
- 19
- Start:
- 54,874,093 bp from pter
- End:
- 54,891,420 bp from pter
- Size:
- 17,328 bases
- Orientation:
- Plus strand
Genomic View for FCAR Gene
Genes around FCAR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.42 by Ensembl
- 19q13.42 by Entrez Gene
- 19q13.42 by HGNC
FCAR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCAR Gene
Proteins for FCAR Gene
-
Protein details for FCAR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24071-FCAR_HUMAN
- Recommended name:
- Immunoglobulin alpha Fc receptor
- Protein Accession:
- P24071
- Q13603
- Q13604
- Q15727
- Q15728
- Q1AJL7
- Q1AJL8
- Q1AJL9
- Q53X38
- Q53X39
- Q92587
- Q92588
- Q92590
- Q92592
- Q92593
- Q9UEK0
Protein attributes for FCAR Gene
- Size:
- 287 amino acids
- Molecular mass:
- 32265 Da
- Quaternary structure:
-
- Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.
Protein Expression for FCAR Gene
Post-translational modifications for FCAR Gene
Other Protein References for FCAR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Abcam antibodies for FCAR
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-
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Protein Products
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Cloud-Clone Corp. Proteins for FCAR
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-
ProSci Proteins for FCAR
-
Abcam proteins for FCAR
No data available for DME Specific Peptides for FCAR Gene
Domains & Families for FCAR Gene
Gene Families for FCAR Gene
Protein Domains for FCAR Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCAR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCAR Gene
Function for FCAR Gene
Molecular function for FCAR Gene
- GENATLAS Biochemistry:
- immunoglobulin A,Fc receptor expressed on granulocyte,monocyte,macrophage,T cell,B cell,complexing with a cytoplasmic homodimer gamma subunit with the immunoreceptor based inhibitory motif (ITIM),natural killer inhibitory receptor family
- UniProtKB/Swiss-Prot Function:
- Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019862 | IgA binding | IEA | -- |
Phenotypes for FCAR Gene
- GenomeRNAi human phenotypes for FCAR:
Animal Model Products
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CRISPR Products
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miRNA for FCAR Gene
- miRTarBase miRNAs that target FCAR
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Inhibitory RNA Products
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Cell Line Products
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Horizon Cell Lines for FCAR
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCAR Gene
Localization for FCAR Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCAR Gene
- Isoform A.1: Cell membrane; Single-pass type I membrane protein.
- Isoform A.2: Cell membrane; Single-pass type I membrane protein.
- Isoform A.3: Cell membrane; Single-pass type I membrane protein.
- Isoform B: Secreted.
- Isoform B-delta-S2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2258698 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for FCAR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Phagosome | ||
| 3 | Staphylococcus aureus infection | ||
Pathways by source for FCAR Gene
3 Reactome pathways for FCAR Gene
2 KEGG pathways for FCAR Gene
Interacting Proteins for FCAR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | TAS | 10835685 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for FCAR Gene
Transcripts for FCAR Gene
mRNA/cDNA for FCAR Gene
- (13) REFSEQ mRNAs :
- (29) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCAR Gene
CRISPR Products
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OriGene CRISPR knockouts for FCAR
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCAR
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miRNA Products
- Search ViGene Biosciences for FCAR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCAR
- Browse OriGene Inhibitory RNA Products For FCAR
Clone Products
-
OriGene ORF clones in human for FCAR
- RG212404
- RC212404L2
- RC212404L1
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- RC214356L2
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- RC212007L2
- RC212007L1
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- RC214315L1
- RC214315
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- RC222470L2
- RC222470L1
- RC222470
- RG206601
- RC206601L2
- RC206601L1
- RC206601
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA ORF clone for FCAR in any vector
- NM_133274
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- XM_011548699
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- Sino Biological Human cDNA Clone for FCAR
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | - | ||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | - | - | - | - |
Expression for FCAR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for FCAR Gene
This gene is overexpressed in Whole Blood (x46.8).
This gene is overexpressed in Monocytes (44.2) and Neutrophil (24.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCAR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FCAR Gene:
FCARSOURCE GeneReport for Unigene cluster for FCAR Gene:
Hs.659872mRNA Expression by UniProt/SwissProt for FCAR Gene:
P24071-FCAR_HUMAN
Tissue specificity:
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
Evidence on tissue expression from TISSUES for FCAR Gene
- Blood(4.5)
- Bone marrow(4.5)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for FCAR
-
OriGene qPCR primer pairs and template standards for FCAR
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCAR Gene
Orthologs for FCAR Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCAR 34 |
|
||
| PT-FCAR 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | FCAR 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcar 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany |
- Species where no ortholog for FCAR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCAR Gene
Paralogs for FCAR Gene
(4) SIMAP similar genes for FCAR Gene using alignment to 3 proteins:
Variants for FCAR Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11666735 | -- | ||||
| rs16986050 | -- | ||||
| rs201322264 | -- | 54,872,817(+) | AATAC(-/A)AAAAA | upstream-variant-2KB | |
| rs34625687 | -- | 54,879,677(+) | TCACA(-/T)TTTTT | intron-variant | |
| rs72230191 | -- | 54,878,875(+) | CTTGC(-/T)TTTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv438n27 | CNV | gain | 19166990 |
| dgv6580n54 | CNV | gain | 21841781 |
| esv2667609 | CNV | deletion | 23128226 |
| esv2718872 | CNV | deletion | 23290073 |
| esv2758771 | CNV | gain+loss | 17122850 |
| esv3644820 | CNV | loss | 21293372 |
| nsv428372 | CNV | gain+loss | 18775914 |
| nsv469656 | CNV | loss | 16826518 |
| nsv471706 | CNV | loss | 15918152 |
| nsv520644 | CNV | loss | 19592680 |
| nsv833880 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.39;
63.62% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCAR Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAR Gene
Disorders for FCAR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| iga glomerulonephritis |
|
Search FCAR in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FCAR
No data available for UniProtKB/Swiss-Prot and Genatlas for FCAR Gene
Publications for FCAR Gene
- Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. (PMID: 17033823) Watanabe A. … Ra C. (Immunogenetics 2006) 3 22 46 64
- Are single nucleotide polymorphisms of the immunoglobulin A Fc receptor gene associated with allergic asthma? (PMID: 15564774) Jasek M. … KuA9nierczyk P. (Int. Arch. Allergy Immunol. 2004) 3 22 46 64
- IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. (PMID: 9367406) Toyabe S. … Abo T. (Clin. Exp. Immunol. 1997) 3 4 22 64
- Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. (PMID: 8666819) Patry C. … Monteiro R.C. (J. Immunol. 1996) 3 4 22 64
- Structure of the gene for the human myeloid IgA Fc receptor (CD89). (PMID: 7636188) de Wit T.P.M. … van de Winkel J.G.J. (J. Immunol. 1995) 3 4 22 64
Products for FCAR Gene
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCAR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
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- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
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- (37) SGD
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- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
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- (60) miRBase
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- (62) NCBI
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- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
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- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
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- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (140) FANTOM5
- (141) ENCODE
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- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer