Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FCAR Gene

protein-coding   GIFtS: 60
GCID: GC19P055386

Fc Fragment Of IgA, Receptor For

  See FCAR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fc Fragment Of IgA, Receptor For1 2
CD892 3
IgA Fc Receptor2 3
Fc Alpha Receptor2
Immunoglobulin Alpha Fc Receptor2
CD89 Antigen3

External Ids:    HGNC: 36081   Entrez Gene: 22042   Ensembl: ENSG000001864317   OMIM: 1470455   UniProtKB: P240713   

Export aliases for FCAR gene to outside databases

Previous GC identifers: GC19P056248 GC19P055810 GC19P060006 GC19P060077 GC19P051708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FCAR Gene:
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The
receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils,
monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with
IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis,
antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple
alternatively spliced transcript variants encoding different isoforms have been described for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FCAR Gene:
FCAR (Fc fragment of IgA, receptor for) is a protein-coding gene. Diseases associated with FCAR include spondylitis, and oral lichen planus. GO annotations related to this gene include IgA binding. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: FCAR_HUMAN, P24071
Function: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine
production

Gene Wiki entry for FCAR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  NT_187636.1  NT_187641.1  NT_187671.1  NT_187674.1  NT_187675.1  
NT_187676.1  NT_187677.1  NT_187683.1  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCAR gene promoter:
         CREB   RORalpha1   deltaCREB   NF-kappaB1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCAR promoter sequence
   Search Chromatin IP Primers for FCAR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

FCAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCAR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055386:  view genomic region     (about GC identifiers)

Start:
55,385,549 bp from pter      End:
55,401,839 bp from pter
Size:
16,291 bases      Orientation:
plus strand

2 alternative locations:
Chr19+,NW_003571055 519,360-535,701      Chr19+,NW_003571060 778,468-794,838     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FCAR_HUMAN, P24071 (See protein sequence)
Recommended Name: Immunoglobulin alpha Fc receptor precursor  
Size: 287 amino acids; 32265 Da
Subunit: Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2
3 PDB 3D structures from and Proteopedia for FCAR:
1OVZ (3D)        1OW0 (3D)        1UCT (3D)    
Secondary accessions: Q13603 Q13604 Q15727 Q15728 Q1AJL7 Q1AJL8 Q1AJL9 Q53X38 Q53X39 Q92587
Q92588 Q92590 Q92592 Q92593 Q9UEK0
Alternative splicing: 11 isoforms:  P24071-1   P24071-2   P24071-3   P24071-4   P24071-5   P24071-6   P24071-7   P24071-8   
P24071-9   P24071-10   P24071-11   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for FCAR: NX_P24071

Explore proteomics data for FCAR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn79, Asn141, Asn177, Asn186
  • Modification sites at PhosphoSitePlus

  • See FCAR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001991.1  NP_579803.1  NP_579805.1  NP_579806.1  NP_579807.1  NP_579808.1  NP_579811.1  NP_579812.1  
    NP_579813.1  

    ENSEMBL proteins: 
     ENSP00000375606   ENSP00000473814   ENSP00000474512   ENSP00000347714   ENSP00000375605  
     ENSP00000338257   ENSP00000338058   ENSP00000352218   ENSP00000375603   ENSP00000375604  

    FCAR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FCAR (FCAR/CD89)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FCAR
    OriGene Protein Over-expression Lysate for FCAR
    OriGene MassSpec for FCAR
    OriGene Custom Protein Services for FCAR
    GenScript Custom Purified and Recombinant Proteins Services for FCAR
    Novus Biologicals FCAR Proteins
    Novus Biologicals FCAR Lysates
    Sino Biological Recombinant Protein for FCAR
    Sino Biological Cell Lysate for FCAR
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FCAR 

    FCAR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FCAR (FCAR/CD89)
    OriGene Antibodies for FCAR
    OriGene Custom Antibody Services for FCAR
    Novus Biologicals FCAR Antibodies
    Abcam antibodies for FCAR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for FCAR
    LSBio Antibodies in human, mouse, rat for FCAR

    FCAR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FCAR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FCAR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FCAR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P24071

    ProtoNet protein and cluster: P24071

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: FCAR_HUMAN, P24071
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with FCAR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCAR_HUMAN, P24071
    Function: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine
    production

         Genatlas biochemistry entry for FCAR:
    immunoglobulin A,Fc receptor expressed on granulocyte,monocyte,macrophage,T cell,B cell,complexing with a
    cytoplasmic homodimer gamma subunit with the immunoreceptor based inhibitory motif (ITIM),natural killer
    inhibitory receptor family

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019862IgA binding IEA--
         
    Find genes that share ontologies with FCAR           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCAR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCAR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FCAR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FCAR

    miRNA
    Products:
        
    miRTarBase miRNAs that target FCAR:
    hsa-mir-148b-3p (MIRT019354)

    Block miRNA regulation of human, mouse, rat FCAR using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FCAR
    SwitchGear 3'UTR luciferase reporter plasmidFCAR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FCAR
    Predesigned siRNA for gene silencing in human, mouse, rat FCAR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FCAR

    Clone
    Products:
         
    OriGene clones in human, mouse for FCAR (see all 48)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): FCAR (NM_002000)
    Sino Biological Human cDNA Clone for FCAR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCAR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FCAR
    Browse ESI BIO Cell Lines and PureStem Progenitors for FCAR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCAR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FCAR_HUMAN, P24071: Isoform A.1: Cell membrane; Single-pass type I membrane protein
    FCAR_HUMAN, P24071: Isoform A.2: Cell membrane; Single-pass type I membrane protein
    FCAR_HUMAN, P24071: Isoform A.3: Cell membrane; Single-pass type I membrane protein
    FCAR_HUMAN, P24071: Isoform B: Secreted
    FCAR_HUMAN, P24071: Isoform B-delta-S2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IDA--
    GO:0005887integral component of plasma membrane TAS2258698
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with FCAR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FCAR About    
    See pathways by source

    SuperPathContained pathways About
    1Staphylococcus aureus infection
    Staphylococcus aureus infection
    2Phagosome
    Phagosome


    Find genes that share SuperPaths with FCAR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for FCAR):
        Phagosome
    Staphylococcus aureus infection

        Pathway & Disease-focused RT2 Profiler PCR Array including FCAR: 
              HIV Host Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FCAR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FCAR (P240713 ENSP000003477144) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD79AP119123, ENSP000002219724I2D: score=1 STRING: ENSP00000221972
    PILRAQ9UKJ13, ENSP000001985364I2D: score=1 STRING: ENSP00000198536
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    FCGR1AP123143, ENSP000003581654I2D: score=2 STRING: ENSP00000358165
    OSCARQ8IYS53, ENSP000003526714I2D: score=1 STRING: ENSP00000352671
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS10835685

    Find genes that share ontologies with FCAR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCAR

    5 Novoseek inferred chemical compound relationships for FCAR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 28.4 6 9234476 (1), 9427690 (1), 8626653 (1), 9581809 (1) (see all 5)
    mannose 5.4 2 11751952 (1), 8262556 (1)
    oxygen 4.27 1 10477741 (1)
    superoxide 0 1 8014525 (1)
    serine 0 2 11369640 (1), 12023895 (1)



    Find genes that share compounds with FCAR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FCAR gene (10 alternative transcripts): 
    NM_002000.2  NM_133269.2  NM_133271.2  NM_133272.2  NM_133273.2  NM_133274.2  NM_133277.2  NM_133278.2  
    NM_133279.2  NM_133280.1  

    Unigene Cluster for FCAR:

    Fc fragment of IgA, receptor for
    Hs.659872  [show with all ESTs]
    Unigene Representative Sequence: NM_002000
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391726 ENST00000469767 ENST00000488066 ENST00000472634 ENST00000355524(uc002qhr.1 uc002qhs.1 uc002qht.1 uc010esi.1 uc002qhu.1 uc002qhv.1 uc002qhw.1 uc002qhx.1 uc002qhy.1 uc002qhz.1 uc002qia.1)
    ENST00000391725 ENST00000345937 ENST00000353758 ENST00000359272 ENST00000391723
    ENST00000391724 ENST00000482092 ENST00000471750
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FCAR using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FCAR
    SwitchGear 3'UTR luciferase reporter plasmidFCAR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FCAR
    Predesigned siRNA for gene silencing in human, mouse, rat FCAR
    Clone
    Products:
         
    OriGene clones in human, mouse for FCAR (see all 48)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): FCAR (NM_002000)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FCAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCAR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FCAR
    OriGene qSTAR qPCR primer pairs in human, mouse for FCAR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FCAR
      QuantiTect SYBR Green Assays in human, mouse, rat FCAR
      QuantiFast Probe-based Assays in human, mouse, rat FCAR

    Additional mRNA sequence: 

    AK290922.1 BC027953.1 D87853.1 D87854.1 D87855.1 D87856.1 D87857.1 D87858.1 
    D87859.1 D87860.1 D87861.1 D87862.1 DQ075334.1 DQ075335.1 DQ075336.1 DQ075337.1 
    DQ075338.1 DQ075339.1 S82919.1 U43677.1 U43774.1 U56236.1 U56237.1 X90753.1 
    X92558.1 X92559.1 X92560.1 X92561.1 X92562.1 

    11 DOTS entries:

    DT.451562  DT.92421597  DT.100024013  DT.451561  DT.100781093  DT.92476477  DT.100781094  DT.92421596 
    DT.92421598  DT.86840917  DT.121419885 

    Selected AceView cDNA sequences (see all 45):

    NM_133271 NM_133269 NM_002000 BI029218 BI518718 D87853 BF894027 U43677 
    D87856 NM_133274 D87855 NM_133278 D87857 NM_133273 X90753 D87862 
    NM_133272 D87861 NM_133280 D87854 U43774 NM_133277 D87859 D87860 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FCAR (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
    SP1:              -                             -                     
    SP2:              -                 -     -     -                     
    SP3:              -                       -     -                     
    SP4:                                      -     -                     
    SP5:                                            -                     


    ECgene alternative splicing isoforms for FCAR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FCAR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAAACCAA
    FCAR Expression
    About this image

    FCAR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCAR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659872

    UniProtKB/Swiss-Prot: FCAR_HUMAN, P24071
    Tissue specificity: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and
    mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and
    isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages
    surfaces

        Pathway & Disease-focused RT2 Profiler PCR Array including FCAR: 
              HIV Host Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FCAR
    OriGene qSTAR qPCR primer pairs in human, mouse for FCAR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FCAR
    QuantiTect SYBR Green Assays in human, mouse, rat FCAR
    QuantiFast Probe-based Assays in human, mouse, rat FCAR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCAR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FCAR gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Fcar1 Fc fragment of IgA, receptor for 68.01(n)
    54.04(a)
      365183  NM_201992.1  NP_973721.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    9(a)
    1 → many
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for FCAR (if available)
    TreeFam Gene Tree for FCAR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FCAR gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  
    KIR3DL32  LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  KIR3DL22  LILRA22  
    KIR2DL32  GP62  LILRB32  
    4 SIMAP similar genes for FCAR using alignment to 3 protein entries:     FCAR_HUMAN (see all proteins):
    GP6    LILRA4    TARM1    LILRA2

    Find genes that share paralogs with FCAR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FCAR (see all 578)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465802161,2
    Cuntested155386805(+) CAGAGA/C/GATTCA 13 R syn1 int11NA 4552
    rs1382425921,2
    --55383618(+) AGTAGA/TGACTG 9 -- us2k10--------
    rs1812643871,2
    --55383777(+) TCTCTA/GCATTT 9 -- us2k10--------
    rs177719791,2
    C,F,H--55383907(+) AATGCG/AGTCAA 9 -- us2k19Minor allele frequency- A:0.04NA NS EA 802
    rs116659861,2
    C,F,H--55383941(+) ATTTCC/TAGAAC 9 -- us2k126Minor allele frequency- T:0.26NA NS EA WA 2898
    rs1867213231,2
    --55383970(+) CCGAAA/CGTAAA 9 -- us2k10--------
    rs177815561,2
    C,F,H--55383977(+) TAAATA/GTGTAT 9 -- us2k110Minor allele frequency- G:0.06NA NS EA WA 920
    rs1914983541,2
    --55384108(+) TCGGCA/GTTGGA 9 -- us2k10--------
    rs1835609891,2
    --55384157(+) GGGCGA/CGGTGG 9 -- us2k10--------
    rs116660551,2
    C,F,H--55384167(+) GCTCAT/CGCCTG 9 -- us2k14Minor allele frequency- C:0.43NA CSA 7

    HapMap Linkage Disequilibrium report for FCAR (55385549 - 55401839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FCAR (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2718872CNV Deletion23290073
    nsv520644CNV Loss19592680
    nsv833880CNV Loss17160897
    nsv471706CNV Loss15918152
    nsv912443CNV Loss21882294
    nsv469656CNV Gain16826518
    dgv438n27CNV Gain19166990
    nsv428372CNV Gain+Loss18775914
    dgv1126e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FCAR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FCAR
    DNA2.0 Custom Variant and Variant Library Synthesis for FCAR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147045    OMIM disorders: --

    3 diseases for FCAR:    
    About MalaCards
    spondylitis    oral lichen planus    aggressive periodontitis


    Find genes that share disorders with FCAR           About GenesLikeMe

    8 Novoseek inferred disease relationships for FCAR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy iga 80.4 11 10344348 (1), 7538927 (1), 9573548 (1), 11776381 (1) (see all 9)
    alcoholic cirrhosis 47.3 1 7636220 (1)
    asthma allergic 12.9 4 15564774 (3)
    spondylitis ankylosing 11.5 4 10685807 (2)
    virus infection 0 1 17033823 (1)
    necrosis 0 3 2010162 (1), 8014525 (1), 12560105 (1)
    tumors 0 11 9469424 (1), 9373259 (1), 12393717 (1), 15843545 (1) (see all 10)
    lymphoma 0 1 20042573 (1)

    Genetic Association Database (GAD): FCAR
    Human Genome Epidemiology (HuGE) Navigator: FCAR (14 documents)

    Export disorders for FCAR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FCAR gene, integrated from 10 sources (see all 177):
    (articles sorted by number of sources associating them with FCAR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. (PubMed id 17033823)1, 4, 9 Watanabe A....Ra C. (Immunogenetics 2006)
    2. Are single nucleotide polymorphisms of the immunoglobulin A Fc receptor gene associated with allergic asthma? (PubMed id 15564774)1, 4, 9 Jasek M....KuA9nierczyk P. (Int. Arch. Allergy Immunol. 2004)
    3. IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. (PubMed id 9367406)1, 2, 9 Toyabe S.... Abo T. (Clin. Exp. Immunol. 1997)
    4. Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. (PubMed id 8666819)1, 2, 9 Patry C.... Monteiro R.C. (J. Immunol. 1996)
    5. Structure of the gene for the human myeloid IgA Fc receptor (CD89). (PubMed id 7636188)1, 2, 9 de Wit T.P.M.... van de Winkel J.G.J. (J. Immunol. 1995)
    6. Crystal structure of the ectodomain of human FcalphaRI. (PubMed id 12783876)1, 2, 9 Ding Y.... Rao Z. (J. Biol. Chem. 2003)
    7. Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2. (PubMed id 7522255)1, 2, 9 Pfefferkorn L.C. and Yeaman G.R. (J. Immunol. 1994)
    8. The gene for the human IgA Fc receptor maps to 19q13.4. (PubMed id 1577457)1, 3, 9 Kremer E.J....Maliszewski C.R. (Hum. Genet. 1992)
    9. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    10. Assessment of 14 functional gene polymorphisms in Japanese patients with oral lichen planus: a pilot case-control study. (PubMed id 19497711)1, 4 Fujita H....Yoshie H. (Int J Oral Maxillofac Surg 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2204 HGNC: 3608 AceView: FCAR Ensembl:ENSG00000186431 euGenes: HUgn2204
    ECgene: FCAR Kegg: 2204 H-InvDB: FCAR

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FCAR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FCAR gene:
    Search GeneIP for patents involving FCAR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for FCAR (FCAR/CD89)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FCAR (FCAR/CD89)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FCAR   OriGene RNAi products in human, mouse, rat for FCAR  
     OriGene qPCR primer pairs and template standards for FCAR   OriGene Protein Over-expression Lysate for FCAR  
     OriGene MassSpec something-or-other for FCAR   OriGene clones in human, mouse for FCAR  
     OriGene qSTAR qPCR primer pairs in human, mouse for FCAR   OriGene Purified Protein for FCAR  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FCAR   OriGene Custom Protein Services for FCAR  

     
     
     Block miRNA regulation of human, mouse, rat FCAR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FCAR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCAR Predesigned siRNA for gene silencing in human, mouse, rat FCAR
     QuantiFast Probe-based Assays in human, mouse, rat FCAR QuantiTect SYBR Green Assays in human, mouse, rat FCAR
     PCR Arrays including human, mouse, rat FCAR Search Chromatin IP Primers for FCAR
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FCAR  GeneGlobe Interaction Network for FCAR
     Regulatory tfbs in FCAR promoter
     GenScript Custom Purified and Recombinant Proteins Services for FCAR GenScript cDNA clones with any tag delivered in your preferred vector for FCAR
     GenScript Custom Assay Services for FCAR GenScript Custom overexpressing Cell Line Services for FCAR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FCAR
     Proteins for FCAR
     Cell Lysates for FCAR
     cDNA Clones for FCAR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FCAR antibodies
     FCAR proteins
     FCAR lysates
     Antibodies for FCAR
     See all of Abcam's Antibodies, Kits and Proteins for FCAR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FCAR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCAR
     SwitchGear 3'UTR luciferase reporter plasmids for FCAR
     SwitchGear Promoter luciferase reporter plasmids for FCAR
     ThermoFisher Antibodies for FCAR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FCAR
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCAR
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FCAR
     LSBio Antibodies in human, mouse, rat for FCAR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FCAR
      Search eBioscience for proteins for FCAR
      Search eBioscience for elisas for FCAR
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FCAR gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4