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Aliases for FCAMR Gene

Aliases for FCAMR Gene

  • Fc Fragment Of IgA And IgM Receptor 2 3 5
  • Fc Receptor, IgA, IgM, High Affinity 2 3
  • Fc Alpha/Mu Receptor 3 4
  • High Affinity Immunoglobulin Alpha And Immunoglobulin Mu Fc Receptor 3
  • Receptor For Fc Fragment Of IgA And IgM 3
  • Immunity Related Factor 3
  • CD351 Antigen 4
  • FCA/MR 3
  • FKSG87 3
  • CD351 3

External Ids for FCAMR Gene

Previous GeneCards Identifiers for FCAMR Gene

  • GC01M203521
  • GC01M205197
  • GC01M207131
  • GC01M177828

Summaries for FCAMR Gene

GeneCards Summary for FCAMR Gene

FCAMR (Fc Fragment Of IgA And IgM Receptor) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include transmembrane signaling receptor activity and IgM binding. An important paralog of this gene is PIGR.

UniProtKB/Swiss-Prot for FCAMR Gene

  • Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.

Additional gene information for FCAMR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCAMR Gene

Genomics for FCAMR Gene

Regulatory Elements for FCAMR Gene

Enhancers for FCAMR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H206917 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +47.6 47589 11 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 CDCA4P4 EIF2D MAPKAPK2 ENSG00000271680 CD46 PIGR FCAMR RPL7AP20 IL20 IL19
GH01H207017 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -56.0 -56010 18 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF766 FOS DEK EIF2D C4BPA C4BPB FCAMR PIGR FCMR CDCA4P4 RPL7AP20 IL20 PFKFB2
GH01H207004 1.5 Ensembl ENCODE dbSUPER 11.2 -37.1 -37145 7 HDGF PKNOX1 ARNT ARID4B SIN3A BRCA1 ZNF2 ZNF766 GATA2 ZNF143 PIGR FCMR FCAMR IL24 IL20 PFKFB2 MAPKAPK2 IL19 C4BPB TRP-TGG5-1
GH01H206712 1.5 Ensembl ENCODE dbSUPER 10.4 +255.5 255514 5 FOXA2 PKNOX1 ATF1 YY1 TCF12 ZNF121 ZNF766 GATA2 ELK1 ZNF143 MAPKAPK2 IL19 FCMR PIGR FCAMR EIF2D IL24 IL20 RASSF5 C1orf147
GH01H206765 1.5 Ensembl ENCODE dbSUPER 10.1 +204.2 204211 1 HDGF PKNOX1 FOXA2 TCF12 ZNF766 FOS ATF7 RUNX3 NCOA1 JUNB IL19 IL24 PIGR FCAMR IL20 C4BPB GC01M206760 ENSG00000284486
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCAMR on UCSC Golden Path with GeneCards custom track

Genomic Location for FCAMR Gene

Chromosome:
1
Start:
206,957,647 bp from pter
End:
206,970,659 bp from pter
Size:
13,013 bases
Orientation:
Minus strand

Genomic View for FCAMR Gene

Genes around FCAMR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCAMR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCAMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCAMR Gene

Proteins for FCAMR Gene

  • Protein details for FCAMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWV6-FCAMR_HUMAN
    Recommended name:
    High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
    Protein Accession:
    Q8WWV6
    Secondary Accessions:
    • Q32M82
    • Q8WWV5
    • Q96SA2

    Protein attributes for FCAMR Gene

    Size:
    532 amino acids
    Molecular mass:
    57144 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI09264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI09265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FCAMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCAMR Gene

Post-translational modifications for FCAMR Gene

No data available for DME Specific Peptides for FCAMR Gene

Domains & Families for FCAMR Gene

Gene Families for FCAMR Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FCAMR Gene

Suggested Antigen Peptide Sequences for FCAMR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCAMR: view

No data available for UniProtKB/Swiss-Prot for FCAMR Gene

Function for FCAMR Gene

Molecular function for FCAMR Gene

UniProtKB/Swiss-Prot Function:
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma in mesangial cells.

Phenotypes From GWAS Catalog for FCAMR Gene

Gene Ontology (GO) - Molecular Function for FCAMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0019862 IgA binding IEA --
genes like me logo Genes that share ontologies with FCAMR: view
genes like me logo Genes that share phenotypes with FCAMR: view

Animal Models for FCAMR Gene

MGI Knock Outs for FCAMR:

Animal Model Products

  • Taconic Biosciences Mouse Models for FCAMR

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FCAMR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCAMR Gene

Localization for FCAMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCAMR Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCAMR gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for FCAMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCAMR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCAMR Gene

Pathways & Interactions for FCAMR Gene

genes like me logo Genes that share pathways with FCAMR: view

Pathways by source for FCAMR Gene

1 BioSystems pathway for FCAMR Gene
2 Reactome pathways for FCAMR Gene

Interacting Proteins for FCAMR Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316491%0d%0a9606.ENSP00000305988%0d%0a
Selected Interacting proteins: Q8WWV6-FCAMR_HUMAN ENSP00000316491 for FCAMR Gene via IID STRING

Gene Ontology (GO) - Biological Process for FCAMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007165 signal transduction IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with FCAMR: view

No data available for SIGNOR curated interactions for FCAMR Gene

Drugs & Compounds for FCAMR Gene

No Compound Related Data Available

Transcripts for FCAMR Gene

Unigene Clusters for FCAMR Gene

Fc receptor, IgA, IgM, high affinity:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FCAMR
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FCAMR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for FCAMR Gene

GeneLoc Exon Structure for
FCAMR
ECgene alternative splicing isoforms for
FCAMR

Expression for FCAMR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCAMR Gene

mRNA differential expression in normal tissues according to GTEx for FCAMR Gene

This gene is overexpressed in Liver (x28.8) and Kidney - Cortex (x19.6).

Protein differential expression in normal tissues from HIPED for FCAMR Gene

This gene is overexpressed in Amniocyte (61.7) and Platelet (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCAMR Gene



Protein tissue co-expression partners for FCAMR Gene

NURSA nuclear receptor signaling pathways regulating expression of FCAMR Gene:

FCAMR

SOURCE GeneReport for Unigene cluster for FCAMR Gene:

Hs.145519

mRNA Expression by UniProt/SwissProt for FCAMR Gene:

Q8WWV6-FCAMR_HUMAN
Tissue specificity: Expressed by mesangial cells.

Evidence on tissue expression from TISSUES for FCAMR Gene

  • Lymph node(4.4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FCAMR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCAMR Gene

Orthologs for FCAMR Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCAMR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCAMR 33 34
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia FCAMR 34 33
  • 76.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FCAMR 33 34
  • 71.21 (n)
rat
(Rattus norvegicus)
Mammalia Fcamr 33
  • 70.22 (n)
mouse
(Mus musculus)
Mammalia Fcamr 33 16 34
  • 70.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FCAMR 34
  • 29 (a)
OneToOne
Species where no ortholog for FCAMR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCAMR Gene

ENSEMBL:
Gene Tree for FCAMR (if available)
TreeFam:
Gene Tree for FCAMR (if available)

Paralogs for FCAMR Gene

Paralogs for FCAMR Gene

genes like me logo Genes that share paralogs with FCAMR: view

Variants for FCAMR Gene

Sequence variations from dbSNP and Humsavar for FCAMR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000295826 -- 206,971,462(+) CCTTG(C/T)CTTCC upstream-variant-2KB
rs1000445185 -- 206,964,289(+) GTGGT(A/T)CAACA intron-variant
rs1000720958 -- 206,960,110(+) TTCCT(C/T)GTGGC intron-variant
rs1000748260 -- 206,958,718(+) TAAGG(A/G/T)CAGCA intron-variant
rs1000786172 -- 206,962,907(+) TCACT(A/C)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCAMR Gene

Variant ID Type Subtype PubMed ID
nsv1010486 CNV gain 25217958
nsv468049 CNV loss 19166990
nsv526285 CNV loss 19592680
nsv549071 CNV loss 21841781
nsv832426 CNV gain 17160897

Variation tolerance for FCAMR Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCAMR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCAMR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAMR Gene

Disorders for FCAMR Gene

Relevant External Links for FCAMR

Genetic Association Database (GAD)
FCAMR
Human Genome Epidemiology (HuGE) Navigator
FCAMR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCAMR

No disorders were found for FCAMR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCAMR Gene

Publications for FCAMR Gene

  1. Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. (PMID: 11779189) McDonald KJ … Jardine AG (Biochemical and biophysical research communications 2002) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. (PMID: 11062505) Shibuya A … Nakauchi H (Nature immunology 2000) 3 4 60
  4. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. (PMID: 28355232) Ward-Caviness CK … Hauser ER (PloS one 2017) 3 60
  5. Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199. (PMID: 26138065) Schneider BP … Sledge GW (Clinical cancer research : an official journal of the American Association for Cancer Research 2015) 3 60

Products for FCAMR Gene

Sources for FCAMR Gene

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