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Aliases for FCAMR Gene

Aliases for FCAMR Gene

  • Fc Receptor, IgA, IgM, High Affinity 2 3
  • Fc Alpha/Mu Receptor 3 4
  • Receptor For Fc Fragment Of IgA And IgM 3
  • Immunity Related Factor 3
  • CD351 Antigen 4
  • FCA/MR 3
  • FKSG87 3
  • CD351 3

External Ids for FCAMR Gene

Previous GeneCards Identifiers for FCAMR Gene

  • GC01M203521
  • GC01M205197
  • GC01M207131
  • GC01M177828

Summaries for FCAMR Gene

GeneCards Summary for FCAMR Gene

FCAMR (Fc Receptor, IgA, IgM, High Affinity) is a Protein Coding gene. Among its related pathways are CD40/CD40L signaling. GO annotations related to this gene include transmembrane signaling receptor activity and IgM binding. An important paralog of this gene is PIGR.

UniProtKB/Swiss-Prot for FCAMR Gene

  • Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCAMR Gene

Genomics for FCAMR Gene

Regulatory Elements for FCAMR Gene

Genomic Location for FCAMR Gene

Chromosome:
1
Start:
206,957,647 bp from pter
End:
206,970,659 bp from pter
Size:
13,013 bases
Orientation:
Minus strand

Genomic View for FCAMR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCAMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCAMR Gene

Proteins for FCAMR Gene

  • Protein details for FCAMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWV6-FCAMR_HUMAN
    Recommended name:
    High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
    Protein Accession:
    Q8WWV6
    Secondary Accessions:
    • Q32M82
    • Q8WWV5
    • Q96SA2

    Protein attributes for FCAMR Gene

    Size:
    532 amino acids
    Molecular mass:
    57144 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI09264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI09265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FCAMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCAMR Gene

Proteomics data for FCAMR Gene at MOPED

Post-translational modifications for FCAMR Gene

Other Protein References for FCAMR Gene

No data available for DME Specific Peptides for FCAMR Gene

Domains & Families for FCAMR Gene

Gene Families for FCAMR Gene

Protein Domains for FCAMR Gene

Suggested Antigen Peptide Sequences for FCAMR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWV6

UniProtKB/Swiss-Prot:

FCAMR_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with FCAMR: view

Function for FCAMR Gene

Molecular function for FCAMR Gene

UniProtKB/Swiss-Prot Function:
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma in mesangial cells.

Gene Ontology (GO) - Molecular Function for FCAMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001791 IgM binding --
GO:0004888 transmembrane signaling receptor activity --
GO:0005515 protein binding --
GO:0019862 IgA binding --
genes like me logo Genes that share ontologies with FCAMR: view
genes like me logo Genes that share phenotypes with FCAMR: view

Animal Models for FCAMR Gene

MGI Knock Outs for FCAMR:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCAMR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FCAMR Gene

Localization for FCAMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCAMR Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCAMR Gene COMPARTMENTS Subcellular localization image for FCAMR gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for FCAMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCAMR: view

Pathways & Interactions for FCAMR Gene

SuperPathways for FCAMR Gene

Superpath Contained pathways
1 CD40/CD40L signaling
genes like me logo Genes that share pathways with FCAMR: view

Pathways by source for FCAMR Gene

1 BioSystems pathway for FCAMR Gene

Interacting Proteins for FCAMR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316491%0d%0a9606.ENSP00000305988%0d%0a9606.ENSP00000269305%0d%0a
Selected Interacting proteins: ENSP00000316491 for FCAMR Gene via STRING

Gene Ontology (GO) - Biological Process for FCAMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with FCAMR: view

No data available for SIGNOR curated interactions for FCAMR Gene

Drugs & Compounds for FCAMR Gene

No Compound Related Data Available

Transcripts for FCAMR Gene

Unigene Clusters for FCAMR Gene

Fc receptor, IgA, IgM, high affinity:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCAMR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCAMR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for FCAMR Gene

GeneLoc Exon Structure for
FCAMR
ECgene alternative splicing isoforms for
FCAMR

Expression for FCAMR Gene

mRNA expression in normal human tissues for FCAMR Gene

mRNA differential expression in normal tissues according to GTEx for FCAMR Gene

This gene is overexpressed in Liver (x28.8) and Kidney - Cortex (x19.6).

Protein differential expression in normal tissues from HIPED for FCAMR Gene

This gene is overexpressed in Amniocyte (61.7) and Platelet (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCAMR Gene



SOURCE GeneReport for Unigene cluster for FCAMR Gene Hs.145519

mRNA Expression by UniProt/SwissProt for FCAMR Gene

Q8WWV6-FCAMR_HUMAN
Tissue specificity: Expressed by mesangial cells.
genes like me logo Genes that share expression patterns with FCAMR: view

Protein tissue co-expression partners for FCAMR Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FCAMR Gene

Orthologs for FCAMR Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCAMR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCAMR 35
  • 71.21 (n)
  • 55.97 (a)
FCAMR 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCAMR 35
  • 76.31 (n)
  • 60.04 (a)
FCAMR 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcamr 35
  • 70.14 (n)
  • 54.17 (a)
Fcamr 16
Fcamr 36
  • 43 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FCAMR 35
  • 98.96 (n)
  • 98.27 (a)
FCAMR 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcamr 35
  • 70.22 (n)
  • 55.89 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FCAMR 36
  • 29 (a)
OneToOne
Species with no ortholog for FCAMR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCAMR Gene

ENSEMBL:
Gene Tree for FCAMR (if available)
TreeFam:
Gene Tree for FCAMR (if available)

Paralogs for FCAMR Gene

Paralogs for FCAMR Gene

genes like me logo Genes that share paralogs with FCAMR: view

Variants for FCAMR Gene

Sequence variations from dbSNP and Humsavar for FCAMR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs863471 -- 206,963,271(+) GCACA(C/G)ATGAG intron-variant
rs865171 -- 206,963,241(+) AAACA(C/G)AAACA intron-variant
rs866350 -- 206,960,313(-) CCACA(A/C)GACAG intron-variant
rs866351 -- 206,963,722(+) GGGCA(C/G)AGTGG intron-variant
rs1340232 -- 206,970,205(+) GCTCT(C/T)CTTTA utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FCAMR Gene

Variant ID Type Subtype PubMed ID
nsv468049 CNV Loss 19166990
nsv832426 CNV Gain 17160897
nsv526285 CNV Loss 19592680

Variation tolerance for FCAMR Gene

Residual Variation Intolerance Score: 77.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCAMR Gene

HapMap Linkage Disequilibrium report
FCAMR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAMR Gene

Disorders for FCAMR Gene

Relevant External Links for FCAMR

Genetic Association Database (GAD)
FCAMR
Human Genome Epidemiology (HuGE) Navigator
FCAMR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCAMR
genes like me logo Genes that share disorders with FCAMR: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCAMR Gene

Publications for FCAMR Gene

  1. Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. (PMID: 11779189) McDonald K.J. … Jardine A.G. (Biochem. Biophys. Res. Commun. 2002) 2 23 67
  2. Transferrin receptor and Fc alpha/mu receptor may not be the major IgA1 receptor on human mesangial cells. (PMID: 15899145) Hu R.H. … Zhao M.H. (Chin. Med. J. 2005) 23 67
  3. A novel Fc receptor for IgA and IgM is expressed on both hematopoietic and non-hematopoietic tissues. (PMID: 11465087) Sakamoto N. … Shibuya A. (Eur. J. Immunol. 2001) 23 67
  4. IgA in serum: An old acquaintance as a new prognostic biomarker in Idiopathic Pulmonary Fibrosis. (PMID: 25845491) Ten Klooster L. … Grutters J.C. (Clin. Exp. Immunol. 2015) 67
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67

Products for FCAMR Gene

Sources for FCAMR Gene

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