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FCAMR Gene

protein-coding   GIFtS: 49
GCID: GC01M207131

Fc Receptor, IgA, IgM, High Affinity

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fc Receptor, IgA, IgM, High Affinity1 2     High Affinity Immunoglobulin Alpha And Immunoglobulin Mu Fc Receptor2
Fc Alpha/Mu Receptor2 3     Immunity Related Factor2
CD3512     Receptor For Fc Fragment Of IgA And IgM2
FCA/MR2     CD351 Antigen3

External Ids:    HGNC: 246921   Entrez Gene: 839532   Ensembl: ENSG000001628977   OMIM: 6054845   UniProtKB: Q8WWV63   

Export aliases for FCAMR gene to outside databases

Previous GC identifers: GC01M203521 GC01M205197 GC01M177828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FCAMR Gene:
FCAMR (Fc receptor, IgA, IgM, high affinity) is a protein-coding gene. An important paralog of this gene is FAIM3.

UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6
Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and
mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FCAMR gene promoter:
         Max1   C/EBPbeta   HOXA3   LCR-F1   GATA-1   Meis-1b   HEN1   c-Myb   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFCAMR promoter sequence
   Search Chromatin IP Primers for FCAMR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FCAMR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

FCAMR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCAMR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M207131:  view genomic region     (about GC identifiers)

Start:
207,131,310 bp from pter      End:
207,143,970 bp from pter
Size:
12,661 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6 (See protein sequence)
Recommended Name: High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor precursor  
Size: 532 amino acids; 57144 Da
Sequence caution: Sequence=AAI09264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI09265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q32M82 Q8WWV5 Q96SA2
Alternative splicing: 4 isoforms:  Q8WWV6-1   Q8WWV6-2   Q8WWV6-3   Q8WWV6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FCAMR: NX_Q8WWV6

Explore proteomics data for FCAMR at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn167
  • Modification sites at PhosphoSitePlus

  • See FCAMR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116451.1  NP_001164102.1  NP_114418.2  

    ENSEMBL proteins: 
     ENSP00000317155   ENSP00000316491   ENSP00000392707   ENSP00000383746  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8WWV6

    ProtoNet protein and cluster: Q8WWV6

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with FCAMR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCAMR_HUMAN, Q8WWV6
    Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and
    mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM
    Induction: Up-regulated by IFNG/IFN-gamma in mesangial cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001791IgM binding ----
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding ----
    GO:0019862IgA binding ----
         
    Find genes that share ontologies with FCAMR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FCAMR:
     Decreased TP53 protein express 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fcamr):
     hematopoietic system  immune system 

    Find genes that share phenotypes with FCAMR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FCAMR: Fcamrtm2Shib Fcamrtm1Shib

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FCAMR
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCAMR_HUMAN, Q8WWV6: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FCAMR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FCAMR About    
    See pathways by source

    SuperPathContained pathways About
    1CD40/CD40L signaling
    CD40/CD40L signaling


    1 BioSystems Pathway for FCAMR
        CD40/CD40L signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FCAMR
    Interactions:

        Search GeneGlobe Interaction Network for FCAMR

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FCAMR (ENSP000003837464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53ENSP000002693054STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--

    Find genes that share ontologies with FCAMR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FCAMR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FCAMR gene (4 alternative transcripts): 
    NM_001122980.1  NM_001122979.2  NM_001170631.1  NM_032029.4  

    Unigene Cluster for FCAMR:

    Fc receptor, IgA, IgM, high affinity
    Hs.145519  [show with all ESTs]
    Unigene Representative Sequence: NM_001170631
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324863(uc021pig.1 uc001hfa.4) ENST00000324852 ENST00000450945
    ENST00000486178 ENST00000487149 ENST00000488345 ENST00000400962(uc001hfb.3 uc009xca.2)

    miRNA
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    Additional mRNA sequence: 

    AF354295.1 AK298394.1 AY063125.1 BC109263.1 BC109264.2 

    2 DOTS entries:

    DT.75101808  DT.95320997 

    Selected AceView cDNA sequences (see all 27):

    AF354295 AW301263 AY063126 NM_032029 BX090153 AW772488 AW058538 BV170789 
    CD633527 BF197636 AI261348 AY063125 CD633525 AI269147 AI793037 AI478563 
    BI760725 CD633520 AI492177 AW028140 AI793214 AI953508 AI768424 AW242378 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FCAMR    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:                                                        -     -                           
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          


    ECgene alternative splicing isoforms for FCAMR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FCAMR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTATATTT
    FCAMR Expression
    About this image

    FCAMR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FCAMR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.145519

    UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6
    Tissue specificity: Expressed by mesangial cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FCAMR gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fcamr1 , 5 Fc receptor, IgA, IgM, high affinity1, 5 70.14(n)1
    54.17(a)1
      1 (56.89 cM)5
    644351  NM_144960.21  NP_659209.21 
     1308009025 


    ENSEMBL Gene Tree for FCAMR (if available)
    TreeFam Gene Tree for FCAMR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FCAMR gene
    FAIM32  PIGR2  

    Find genes that share paralogs with FCAMR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FCAMR (see all 353)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145915821,2
    F--207130960(+) ACCCCC/TAAAAA 3 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1884333121,2
    --207131029(+) GAGGGA/CCTTTA 3 -- ds50010--------
    rs1408859891,2
    --207131072(+) GCTCCC/TCCATG 3 -- ds50010--------
    rs1124989861,2
    C,F--207131303(+) ACTGAG/ACCCCC 3 -- ds50013Minor allele frequency- A:0.15CSA WA 122
    rs1443280151,2
    --207131305(+) TGAGCC/TCCCAA 3 -- ds50010--------
    rs121199831,2
    C,F,H--207131571(+) TATTTT/GCAAAC 3 -- ut3127Minor allele frequency- G:0.24NA NS EA WA 2910
    rs413076501,2
    C,F--207131666(+) CTTGTC/TACCTT 3 -- ut311Minor allele frequency- T:0.01NA 120
    rs170183161,2
    C,F,H--207131740(+) AGCACA/C/TGGCTG 6 -- ut31 ese311NA EA NS 944
    rs1808587921,2
    --207131837(+) GGTAAA/CTGAGC 3 -- ut310--------
    rs1849630361,2
    C,F--207131853(+) ATCTCT/GCTGTC 3 -- ut311Minor allele frequency- G:0.00EU 575

    HapMap Linkage Disequilibrium report for FCAMR (207131310 - 207143970 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FCAMR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526285CNV Loss19592680
    nsv468049CNV Loss19166990
    nsv832426CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605484    OMIM disorders: --


    Find genes that share disorders with FCAMR           About GenesLikeMe

    Genetic Association Database (GAD): FCAMR
    Human Genome Epidemiology (HuGE) Navigator: FCAMR (1 document)

    Export disorders for FCAMR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FCAMR gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FCAMR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. (PubMed id 11779189)1, 2, 3, 9 McDonald K.J.... Jardine A.G. (Biochem. Biophys. Res. Commun. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. (PubMed id 11062505)1, 2 Shibuya A.... Nakauchi H. (Nat. Immunol. 2000)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages. (PubMed id 19682689)1 Feng X....Wang H. (Atherosclerosis 2010)
    6. Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface. (PubMed id 19945166)1 Cho Y....Shibuya A. (Mol. Immunol. 2010)
    7. Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17. (PubMed id 20059578)1 Peng M....Zhang W. (Immunology 2010)
    8. Human Fcalpha/muR and pIgR distribute differently in intestinal tissues. (PubMed id 19338768)1 Wang R....Zhang W. (Biochem. Biophys. Res. Commun. 2009)
    9. Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization. (PubMed id 19393604)1 Yang L....Zhang W. (Cell. Immunol. 2009)
    10. Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque. (PubMed id 18379868)1 Vallender E.J....Miller G.M. (Behav. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83953 HGNC: 24692 AceView: FCA\/MR Ensembl:ENSG00000162897 euGenes: HUgn83953
    ECgene: FCAMR H-InvDB: FCAMR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FCAMR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FCAMR gene:
    Search GeneIP for patents involving FCAMR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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