FCAMR Gene
protein-coding GIFtS: 47
GCID: GC01M207131
|
|
Fc receptor, IgA, IgM, high affinity
| |
Aliases
for FCAMR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fc Receptor, IgA, IgM, High Affinity1 2 | | High Affinity Immunoglobulin Alpha And Immunoglobulin Mu Fc Receptor2 | | CD3511 2 | | Immunity Related Factor2 | | FCA/MR1 2 | | Receptor For Fc Fragment Of IgA And IgM2 | | Fc Alpha/Mu Receptor2 3 | | CD351 Antigen3 | | FKSG871 | | |
Export aliases for FCAMR gene to outside databasesPrevious GC identifers: GC01M203521 GC01M205197 GC01M177828 |
Summaries
for FCAMR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediatestheir endocytosis. May function in the immune response to microbes mediated by IgA and IgM
|
Genomic Views
for FCAMR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FCAMR gene promoter:
Max1 C/EBPbeta HOXA3 LCR-F1 GATA-1 Meis-1b HEN1 c-Myb Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FCAMR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCAMR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1FCAMR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M207131: view genomic region
(about GC identifiers)
Start:
|
207,131,310 bp from pter |
End:
|
207,143,970 bp from pter |
Size:
|
12,661 bases |
Orientation:
|
minus strand |
|
Proteins
for FCAMR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6 (See
protein sequence)Recommended Name: High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor precursor Size: 532 amino acids; 57144 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=AAI09264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAI09265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q32M82 Q8WWV5 Q96SA2Alternative splicing: 4 isoforms: Q8WWV6-1 Q8WWV6-2 Q8WWV6-3 Q8WWV6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FCAMR: NX_Q8WWV6
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWV6
FCAMR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001116451.1 NP_001164102.1 NP_114418.2
ENSEMBL proteins: ENSP00000317155 ENSP00000316491 ENSP00000392707 ENSP00000383746
Human Recombinant Protein Products for FCAMR:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FCAMR for ontologies About GeneDecksing
FCAMR Antibody Products:
Assay Products for FCAMR: |
Protein
Domains /
Families
for FCAMR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FCAMR for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WWV6ProtoNet protein and cluster: Q8WWV6 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for FCAMR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FCAMR_HUMAN, Q8WWV6Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediatestheir endocytosis. May function in the immune response to microbes mediated by IgA and IgMInduction: Up-regulated by IFNG/IFN-gamma in mesangial cells Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FCAMR for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for FCAMR:
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fcamr):
FCAMR for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for FCAMR: Fcamrtm2Shib Fcamrtm1Shib
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCAMR (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCAMR (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FCAMR | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FCAMR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCAMR |
|
Pathways & Interactions
for FCAMR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | CD40/CD40L signaling | |
1  BioSystems Pathway for FCAMR
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FCAMR
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FCAMR (ENSP000003837464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FCAMR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FCAMR
Search CenterWatch for drugs/clinical trials and news about FCAMR
|
Transcripts
for FCAMR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FCAMR gene (4 alternative transcripts): NM_001122980.1 NM_001122979.2 NM_001170631.1 NM_032029.4 Unigene Cluster for FCAMR: Fc receptor, IgA, IgM, high affinity Hs.145519 [show with all ESTs]Unigene Representative Sequence: NM_0011706317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324863(uc021pig.1 uc001hfa.4) ENST00000324852 ENST00000450945
ENST00000486178 ENST00000487149 ENST00000488345 ENST00000400962(uc001hfb.3 uc009xca.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FCAMR (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FCAMR (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FCAMR (NM_001122979) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FCAMR | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FCAMR |
Additional cDNA sequence: AF354295.1 AK298394.1 AY063125.1 BC109263.1 BC109264.2 2 DOTS entries: DT.75101808 DT.95320997 24/27 AceView cDNA sequences (see all 27): AF354295 AY063126 AW301263 NM_032029 AI478563 CD633525 BX090153 AW058538 BI760725 AY063125 AI261348 AW772488 BF197636 AI269147 AI793037 CD633527 BV170789 AW028140 AI793214 CD633520 AI492177 AI953508 AI768424 AW242378
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FCAMR About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FCAMR
|
Expression
for FCAMR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FCAMR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTATATTT
About this image
See FCAMR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FCAMR
SOURCE GeneReport for Unigene cluster: Hs.145519
UniProtKB/Swiss-Prot: FCAMR_HUMAN, Q8WWV6Tissue specificity: Expressed by mesangial cells
SABiosciences Custom PCR Arrays for FCAMR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FCAMR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FCAMR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCAMR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCAMR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FCAMR |
Orthologs
for FCAMR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FCAMR gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for FCAMR (if available)
TreeFam Gene Tree for FCAMR (if available) |
Paralogs
for FCAMR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FCAMR gene
- FAIM32 PIGR2
FCAMR for paralogs About GeneDecksing
|
Genomic Variants
for FCAMR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FCAMR (207131310 - 207143970 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FCAMR: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCAMR |
|
Disorders
/ Diseases
for FCAMR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FCAMR for disorders About GeneDecksing
OMIM gene information: 605484
OMIM disorders: --
1  disease for FCAMR: About MalaCardsnephropathy
Human Genome Epidemiology (HuGE) Navigator: FCAMR (1 document)
Export disorders for FCAMR gene to outside databases
|
Publications
for FCAMR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FCAMR gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FCAMR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. (PubMed id 11779189)1, 2, 3, 9 McDonald K.J.... Jardine A.G. (2002)
- Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. (PubMed id 11062505)1, 2 Shibuya A.... Nakauchi H. (2000)
- Requirement of the cytoplasmic portion for dimer form ation of Fcalpha/micro receptor expressed on cell surface. (PubMed id 19945166)1 Cho Y....Shibuya A. (2010)
- Lipopolysaccharide up-regulates the expression of Fca lpha/mu receptor and promotes the binding of oxidized low-density lipoprotein a nd its IgM antibody complex to activated human macrophages. (PubMed id 19682689)1 Feng X....Wang H. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ectodomain shedding of Fcalpha receptor is mediated b y ADAM10 and ADAM17. (PubMed id 20059578)1 Peng M....Zhang W. (2010)
- Cytoplasmic domain of human Fcalpha/mu receptor is re quired for ligand internalization. (PubMed id 19393604)1 Yang L....Zhang W. (2009)
- Human Fcalpha/muR and pIgR distribute differently in intestinal tissues. (PubMed id 19338768)1 Wang R....Zhang W. (2009)
- Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque. (PubMed id 18379868)1 Vallender E.J....Miller G.M. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for FCAMR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FCAMR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FCAMR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FCAMR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FCAMR | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FCAMR gene:
Search GeneIP for patents involving FCAMR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FCAMR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FCAMR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FCAMR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FCAMR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FCAMR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FCAMR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FCAMR |
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