Aliases for FCAMR Gene
Aliases for FCAMR Gene
External Ids for FCAMR Gene
- HGNC: 24692
- Entrez Gene: 83953
- Ensembl: ENSG00000162897
- OMIM: 605484
- UniProtKB: Q8WWV6
Previous GeneCards Identifiers for FCAMR Gene
- GC01M203521
- GC01M205197
- GC01M207131
- GC01M177828
Summaries for FCAMR Gene
GeneCards Summary for FCAMR Gene
FCAMR (Fc Fragment Of IgA And IgM Receptor) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and CD40/CD40L signaling. GO annotations related to this gene include transmembrane signaling receptor activity and IgM binding. An important paralog of this gene is PIGR.
UniProtKB/Swiss-Prot for FCAMR Gene
-
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCAMR Gene
Genomics for FCAMR Gene
Regulatory Elements for FCAMR Gene
Enhancers for FCAMR Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FCAMR on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FCAMR Gene
- Chromosome:
- 1
- Start:
- 206,957,647 bp from pter
- End:
- 206,970,659 bp from pter
- Size:
- 13,013 bases
- Orientation:
- Minus strand
Genomic View for FCAMR Gene
Genes around FCAMR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by Ensembl
- 1q32.1 by Entrez Gene
- 1q32.1 by HGNC
FCAMR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FCAMR Gene
Proteins for FCAMR Gene
-
Protein details for FCAMR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWV6-FCAMR_HUMAN
- Recommended name:
- High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
- Protein Accession:
- Q8WWV6
- Q32M82
- Q8WWV5
- Q96SA2
Protein attributes for FCAMR Gene
- Size:
- 532 amino acids
- Molecular mass:
- 57144 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAI09264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI09265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FCAMR Gene
Post-translational modifications for FCAMR Gene
- N-glycosylated.
- Glycosylation at Asn167
- Modification sites at PhosphoSitePlus
Other Protein References for FCAMR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FCAMR
-
Abcam antibodies for FCAMR
- Invitrogen Antibodies for FCAMR
- antibodies-online Antibodies for FCAMR: See all 7
- GeneTex FCAMR antibody for FCAMR
Protein Products
- R&D Systems Proteins and Enzymes for FCAMR (Fc alpha/mu R)
-
OriGene Purified Proteins for FCAMR
- Search Origene for MassSpec and Protein Over-expression Lysates for FCAMR
- Origene Custom Protein Services for FCAMR
- antibodies-online Proteins for FCAMR: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FCAMR
-
Abcam proteins for FCAMR
Assay Products
- antibodies-online Kits for FCAMR: See all 2
No data available for DME Specific Peptides for FCAMR Gene
Domains & Families for FCAMR Gene
Gene Families for FCAMR Gene
Protein Domains for FCAMR Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FCAMR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FCAMR Gene
Function for FCAMR Gene
Molecular function for FCAMR Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFNG/IFN-gamma in mesangial cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0019862 | IgA binding | IEA | -- |
Phenotypes for FCAMR Gene
- MGI mutant phenotypes for FCAMR:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FCAMR:
Animal Model Products
-
Taconic Biosciences Mouse Models for FCAMR
-
ViGene Biosciences lentiviral particle packaged cDNA for FCAMR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCAMR gene
- Search ViGene Biosciences for FCAMR
CRISPR Products
-
OriGene CRISPR knockouts for FCAMR
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCAMR
- GenScript: Design CRISPR guide RNA sequences for FCAMR
miRNA for FCAMR Gene
- miRTarBase miRNAs that target FCAMR
miRNA Products
- Search ViGene Biosciences for FCAMR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCAMR
- Browse OriGene Inhibitory RNA Products For FCAMR
-
ViGene Biosciences ready-to-package AAV shRNAs for FCAMR gene
Clone Products
- Sino Biological Human cDNA Clone for FCAMR
- R&D Systems cDNA Clones for FCAMR (Fc alpha/mu R)
Cell Line Products
-
Horizon Cell Lines for FCAMR
-
ViGene Biosciences adenoviral particle packaged cDNA for FCAMR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FCAMR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FCAMR gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCAMR Gene
Localization for FCAMR Gene
Subcellular locations from UniProtKB/Swiss-Prot for FCAMR Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for FCAMR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell surface interactions at the vascular wall | ||
| 2 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 3 | CD40/CD40L signaling | ||
Pathways by source for FCAMR Gene
1 BioSystems pathway for FCAMR Gene
2 Reactome pathways for FCAMR Gene
Interacting Proteins for FCAMR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0050900 | leukocyte migration | TAS | -- |
No data available for SIGNOR curated interactions for FCAMR Gene
Transcripts for FCAMR Gene
mRNA/cDNA for FCAMR Gene
- (7) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (27) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FCAMR Gene
- Fc receptor, IgA, IgM, high affinity:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FCAMR
-
Santa Cruz Biotechnology (SCBT) CRISPR for FCAMR
- GenScript: Design CRISPR guide RNA sequences for FCAMR
miRNA Products
- Search ViGene Biosciences for FCAMR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FCAMR
- Browse OriGene Inhibitory RNA Products For FCAMR
-
ViGene Biosciences ready-to-package AAV shRNAs for FCAMR gene
Clone Products
- Sino Biological Human cDNA Clone for FCAMR
- R&D Systems cDNA Clones for FCAMR (Fc alpha/mu R)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: |
Expression for FCAMR Gene
mRNA differential expression in normal tissues according to GTEx for FCAMR Gene
This gene is overexpressed in Liver (x28.8) and Kidney - Cortex (x19.6).
This gene is overexpressed in Amniocyte (61.7) and Platelet (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCAMR Gene
NURSA nuclear receptor signaling pathways regulating expression of FCAMR Gene:
FCAMRSOURCE GeneReport for Unigene cluster for FCAMR Gene:
Hs.145519mRNA Expression by UniProt/SwissProt for FCAMR Gene:
Q8WWV6-FCAMR_HUMAN
Tissue specificity:
Expressed by mesangial cells.
Evidence on tissue expression from TISSUES for FCAMR Gene
- Lymph node(4.4)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for FCAMR
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCAMR Gene
Orthologs for FCAMR Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FCAMR 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FCAMR 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FCAMR 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fcamr 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fcamr 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FCAMR 35 |
|
OneToOne |
- Species where no ortholog for FCAMR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FCAMR Gene
Variants for FCAMR Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000295826 | -- | 206,971,462(+) | CCTTG(C/T)CTTCC | upstream-variant-2KB | |
| rs1000445185 | -- | 206,964,289(+) | GTGGT(A/T)CAACA | intron-variant | |
| rs1000720958 | -- | 206,960,110(+) | TTCCT(C/T)GTGGC | intron-variant | |
| rs1000748260 | -- | 206,958,718(+) | TAAGG(A/G/T)CAGCA | intron-variant | |
| rs1000786172 | -- | 206,962,907(+) | TCACT(A/C)ACTCA | intron-variant |
Residual Variation Intolerance Score:
77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.47;
64.27% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FCAMR Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FCAMR
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAMR Gene
Disorders for FCAMR Gene
Relevant External Links for FCAMR
No disorders were found for FCAMR Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCAMR Gene
Publications for FCAMR Gene
- Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. (PMID: 11779189) McDonald K.J. … Jardine A.G. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. (PMID: 11062505) Shibuya A. … Nakauchi H. (Nat. Immunol. 2000) 3 4 64
- IgA in serum: An old acquaintance as a new prognostic biomarker in Idiopathic Pulmonary Fibrosis. (PMID: 25845491) Ten Klooster L. … Grutters J.C. (Clin. Exp. Immunol. 2015) 3 64
- Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199. (PMID: 26138065) Schneider B.P. … Sledge G.W. (Clin. Cancer Res. 2015) 3 64
Products for FCAMR Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for FCAMR (Fc alpha/mu R)
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for FCAMR (Fc alpha/mu R)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
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- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FCAMR
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FCAMR
- Search Origene for MassSpec and Protein Over-expression Lysates for FCAMR
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FCAMR
- Browse OriGene Inhibitory RNA Products For FCAMR
- OriGene qPCR primer pairs for FCAMR
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- GenScript: Design CRISPR guide RNA sequences for FCAMR
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FCAMR
- Abcam proteins for FCAMR
- Search for Assays for FCAMR at Abcam
- Find your target
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- Taconic Biosciences Mouse Models for FCAMR
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FCAMR
- antibodies-online Antibodies for FCAMR: See all 7
- antibodies-online Kits for FCAMR: See all 2
- antibodies-online Proteins for FCAMR: See all 5
- Search antibodies-online for peptides
- GeneTex FCAMR antibody for FCAMR
- Search GeneTex for Proteins for FCAMR
- ViGene Biosciences adenoviral particle packaged cDNA for FCAMR gene
- ViGene Biosciences lentiviral particle packaged cDNA for FCAMR gene
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- Search ViGene Biosciences for FCAMR
- Horizon Cell Lines for FCAMR
- Cyagen custom Knockout/knockin (KOKI) mouse models for FCAMR
- VectorBuilder custom plasmid, inducible vectors for FCAMR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FCAMR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FCAMR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer