Aliases for FBXW9 Gene
Aliases for FBXW9 Gene
External Ids for FBXW9 Gene
- HGNC: 28136
- Entrez Gene: 84261
- Ensembl: ENSG00000132004
- OMIM: 609074
- UniProtKB: Q5XUX1
Previous GeneCards Identifiers for FBXW9 Gene
- GC19M012661
- GC19M012662
- GC19M012799
- GC19M012372
Summaries for FBXW9 Gene
-
Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXW9 Gene
FBXW9 (F-Box And WD Repeat Domain Containing 9) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System.
UniProtKB/Swiss-Prot for FBXW9 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW9 Gene
Genomics for FBXW9 Gene
Regulatory Elements for FBXW9 Gene
Enhancers for FBXW9 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXW9 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXW9 gene promoter:
Regulatory Element Products
Genomic Location for FBXW9 Gene
- Chromosome:
- 19
- Start:
- 12,688,053 bp from pter
- End:
- 12,696,868 bp from pter
- Size:
- 8,816 bases
- Orientation:
- Minus strand
Genomic View for FBXW9 Gene
Genes around FBXW9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.13 by Ensembl
- 19p13.13 by Entrez Gene
- 19p13.13 by HGNC
FBXW9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXW9 Gene
Proteins for FBXW9 Gene
-
Protein details for FBXW9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5XUX1-FBXW9_HUMAN
- Recommended name:
- F-box/WD repeat-containing protein 9
- Protein Accession:
- Q5XUX1
- B3KVP7
- Q9BT89
Protein attributes for FBXW9 Gene
- Size:
- 488 amino acids
- Molecular mass:
- 54115 Da
- Quaternary structure:
-
- Interacts with SKP1 and CUL1.
Protein Expression for FBXW9 Gene
Post-translational modifications for FBXW9 Gene
Other Protein References for FBXW9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXW9
- Novus Biologicals Antibodies for FBXW9
- Invitrogen Antibodies for FBXW9
- antibodies-online Antibodies for FBXW9: See all 25
- GeneTex FBXW9 antibody for FBXW9
Protein Products
-
OriGene Purified Proteins for FBXW9
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXW9
- Origene Custom Protein Services for FBXW9
- antibodies-online Proteins for FBXW9: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXW9
Assay Products
- antibodies-online Kits for FBXW9: See all 15
No data available for DME Specific Peptides for FBXW9 Gene
Domains & Families for FBXW9 Gene
Gene Families for FBXW9 Gene
Protein Domains for FBXW9 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXW9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXW9 Gene
Function for FBXW9 Gene
Molecular function for FBXW9 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 19159283 |
Phenotypes for FBXW9 Gene
- MGI mutant phenotypes for FBXW9:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FBXW9:
Animal Models for FBXW9 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXW9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW9 gene
- Search ViGene Biosciences for FBXW9
CRISPR Products
-
OriGene CRISPR knockouts for FBXW9
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXW9
- GenScript: Design CRISPR guide RNA sequences for FBXW9
miRNA Products
- Search ViGene Biosciences for FBXW9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXW9
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW9 gene
Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for FBXW9
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXW9 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW9 Gene
Localization for FBXW9 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXW9 Gene
Pathways & Interactions for FBXW9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Chaperonin-mediated protein folding |
.94
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | Metabolism of proteins | ||
Pathways by source for FBXW9 Gene
Interacting Proteins for FBXW9 Gene
Selected Interacting proteins:
ENSP00000376945
Q5XUX1-FBXW9_HUMAN
for FBXW9 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXW9 Gene
Transcripts for FBXW9 Gene
mRNA/cDNA for FBXW9 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (145) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXW9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXW9
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXW9
- GenScript: Design CRISPR guide RNA sequences for FBXW9
miRNA Products
- Search ViGene Biosciences for FBXW9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXW9
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW9 gene
Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - |
Expression for FBXW9 Gene
This gene is overexpressed in Fetal Brain (23.9), Ovary (9.9), Tonsil (9.1), Frontal cortex (8.3), and Testis (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXW9 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBXW9 Gene:
FBXW9SOURCE GeneReport for Unigene cluster for FBXW9 Gene:
Hs.515154Evidence on tissue expression from TISSUES for FBXW9 Gene
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs for FBXW9
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW9 Gene
Orthologs for FBXW9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXW9 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXW9 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXW9 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxw9 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxw9 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXW9 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXW9 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FBXW9 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxw9 34 |
|
||
| Str.10743 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | fbxw9 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mec-15 34 35 |
|
- Species where no ortholog for FBXW9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FBXW9 Gene
No data available for Paralogs for FBXW9 Gene
Variants for FBXW9 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000547606 | -- | 12,698,323(+) | CCCCA(C/T)CATTC | upstream-variant-2KB | |
| rs1000819108 | -- | 12,691,957(+) | CACCA(C/T)GTTGG | intron-variant | |
| rs1000884436 | -- | 12,691,185(+) | ATGGT(C/T)ACCTT | reference, synonymous-codon | |
| rs1000941216 | -- | 12,690,915(+) | AAACC(A/G)AGGTT | intron-variant | |
| rs1001284597 | -- | 12,697,142(+) | ACTGC(A/G)GAGGC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv138n111 | CNV | deletion | 26073780 |
| nsv1160586 | CNV | duplication | 26073780 |
| nsv953977 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.96;
79.88% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXW9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXW9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW9 Gene
Disorders for FBXW9 Gene
Relevant External Links for FBXW9
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXW9
No disorders were found for FBXW9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW9 Gene
Publications for FBXW9 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
Products for FBXW9 Gene
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- Custom Antibody ServicesOriGene Antibodies for FBXW9
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- antibodies-online Antibodies for FBXW9: See all 25
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- antibodies-online Proteins for FBXW9: See all 4
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXW9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer