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Aliases for FBXW9 Gene

Aliases for FBXW9 Gene

  • F-Box And WD Repeat Domain Containing 9 2 3 5
  • F-Box And WD-40 Domain-Containing Protein 9 3 4
  • F-Box And WD-40 Domain Protein 9 2 3
  • Fbw9 3 4
  • F-Box And WD-40 Repeat Containing Protein 9 3
  • Specificity Factor For SCF Ubiquitin Ligase 3
  • F-Box/WD Repeat-Containing Protein 9 3

External Ids for FBXW9 Gene

Previous GeneCards Identifiers for FBXW9 Gene

  • GC19M012661
  • GC19M012662
  • GC19M012799
  • GC19M012372

Summaries for FBXW9 Gene

Entrez Gene Summary for FBXW9 Gene

  • Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW9 Gene

FBXW9 (F-Box And WD Repeat Domain Containing 9) is a Protein Coding gene. Among its related pathways are Immune System and Chaperonin-mediated protein folding.

UniProtKB/Swiss-Prot for FBXW9 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW9 Gene

Genomics for FBXW9 Gene

Regulatory Elements for FBXW9 Gene

Enhancers for FBXW9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F012781 1.7 FANTOM5 ENCODE 30.5 -92.4 -92430 16.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF136 CCDC130 ZNF564 ZNF442 ZNF844 ZNF44 WDR83OS ZNF799 TRMT1 ZNF625
GH19F012880 1.5 FANTOM5 ENCODE 19.9 -186.5 -186481 5.7 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF136 TRMT1 ZNF625 ZNF844 ZNF44 ZNF442 CCDC130 ZNF791 DNASE2 ZNF763
GH19F012609 1.6 FANTOM5 ENCODE 12.5 +84.5 84508 4.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF136 ZNF564 WDR83OS ZNF700 C19orf43 ZNF799 ZNF44 HNRNPA1P10 ZNF791 JUNB
GH19F013148 1.6 FANTOM5 ENCODE 11.6 -456.8 -456827 10.2 CREB3L1 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 ZNF791 ZNF136 ZNF564 ZNF442 CCDC130 WDR83OS ZNF44 C19orf43 WDR83 MTCO1P27
GH19F012983 1.8 FANTOM5 Ensembl ENCODE 10 -287.9 -287875 3.5 HDGF PKNOX1 CREB3L1 ARNT MLX SIN3A ARID4B DMAP1 ZNF2 ZNF143 ZNF136 CCDC130 ZNF564 ZNF625 WDR83OS ZNF844 ZNF442 MRI1 ZNF799 ZNF44
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXW9 on UCSC Golden Path with GeneCards custom track

Promoters for FBXW9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417959 168 1401 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for FBXW9 Gene

12,688,053 bp from pter
12,696,868 bp from pter
8,816 bases
Minus strand

Genomic View for FBXW9 Gene

Genes around FBXW9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW9 Gene

Proteins for FBXW9 Gene

  • Protein details for FBXW9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/WD repeat-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • B3KVP7
    • Q9BT89

    Protein attributes for FBXW9 Gene

    488 amino acids
    Molecular mass:
    54115 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXW9 Gene


neXtProt entry for FBXW9 Gene

Post-translational modifications for FBXW9 Gene

  • Ubiquitination at Lys 215
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXW9 Gene

No data available for DME Specific Peptides for FBXW9 Gene

Domains & Families for FBXW9 Gene

Suggested Antigen Peptide Sequences for FBXW9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 7 WD repeats.
  • Contains 1 F-box domain.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FBXW9: view

Function for FBXW9 Gene

Molecular function for FBXW9 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXW9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19159283
genes like me logo Genes that share ontologies with FBXW9: view
genes like me logo Genes that share phenotypes with FBXW9: view

Animal Models for FBXW9 Gene

MGI Knock Outs for FBXW9:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW9 Gene

Localization for FBXW9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW9 gene
Compartment Confidence
cytosol 5
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXW9 Gene

Pathways & Interactions for FBXW9 Gene

genes like me logo Genes that share pathways with FBXW9: view

Gene Ontology (GO) - Biological Process for FBXW9 Gene


No data available for SIGNOR curated interactions for FBXW9 Gene

Transcripts for FBXW9 Gene

Unigene Clusters for FBXW9 Gene

F-box and WD repeat domain containing 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for FBXW9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXW9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXW9 Gene

Protein differential expression in normal tissues from HIPED for FBXW9 Gene

This gene is overexpressed in Fetal Brain (23.9), Ovary (9.9), Tonsil (9.1), Frontal cortex (8.3), and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXW9 Gene

Protein tissue co-expression partners for FBXW9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXW9 Gene:


SOURCE GeneReport for Unigene cluster for FBXW9 Gene:

genes like me logo Genes that share expression patterns with FBXW9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXW9 Gene

Orthologs for FBXW9 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXW9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXW9 34 35
  • 98.84 (n)
(Bos Taurus)
Mammalia FBXW9 34 35
  • 85.08 (n)
(Canis familiaris)
Mammalia FBXW9 34 35
  • 85.08 (n)
(Mus musculus)
Mammalia Fbxw9 34 16 35
  • 80.2 (n)
(Rattus norvegicus)
Mammalia Fbxw9 34
  • 80.06 (n)
(Monodelphis domestica)
Mammalia FBXW9 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia FBXW9 35
  • 58 (a)
(Anolis carolinensis)
Reptilia FBXW9 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw9 34
  • 60.29 (n)
Str.10743 34
(Danio rerio)
Actinopterygii fbxw9 34 35
  • 58.48 (n)
(Caenorhabditis elegans)
Secernentea mec-15 34 35
  • 41.75 (n)
Species where no ortholog for FBXW9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXW9 Gene

Gene Tree for FBXW9 (if available)
Gene Tree for FBXW9 (if available)

Paralogs for FBXW9 Gene

No data available for Paralogs for FBXW9 Gene

Variants for FBXW9 Gene

Sequence variations from dbSNP and Humsavar for FBXW9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402775 -- 12,693,046(+) atccc(A/G)ctgag intron-variant
rs10404612 -- 12,693,135(+) acagc(C/G)aggaa intron-variant
rs10405216 -- 12,693,059(+) gggca(A/C)tattg intron-variant
rs10409345 -- 12,698,345(+) CTGTT(A/T)TTCTC upstream-variant-2KB
rs10411280 -- 12,693,419(+) tttgg(A/G)aggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW9 Gene

Variant ID Type Subtype PubMed ID
nsv953977 CNV deletion 24416366
nsv1160586 CNV duplication 26073780
dgv138n111 CNV deletion 26073780

Variation tolerance for FBXW9 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.96; 79.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXW9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW9 Gene

Disorders for FBXW9 Gene

Relevant External Links for FBXW9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXW9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW9 Gene

Publications for FBXW9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for FBXW9 Gene

Sources for FBXW9 Gene

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