FBXW9 Gene
protein-coding GIFtS: 47
GCID: GC19M012799
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F-box and WD repeat domain containing 9(Previous name: F-box and WD-40 domain protein 9 )
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Aliases
for FBXW9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And WD Repeat Domain Containing 91 2 | | F-Box And WD-40 Repeat Containing Protein 92 | | Fbw91 2 | | F-Box/WD Repeat-Containing Protein 92 | | F-Box And WD-40 Domain Protein 91 2 | | Specificity Factor For SCF Ubiquitin Ligase2 | | F-Box And WD-40 Domain-Containing Protein 92 3 | | FBW93 | | MGC108701 | | |
Export aliases for FBXW9 gene to outside databasesPrevious GC identifers: GC19M012661 GC19M012662 GC19M012372 |
Summaries
for FBXW9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXW9:
Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FBXW9_HUMAN, Q5XUX1Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
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Genomic Views
for FBXW9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXW9 gene promoter:
Tal-1 p53 Nkx5-1 C/EBPalpha Egr-4 Evi-1 E47 c-Ets-1 CHOP-10 Pax-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXW9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2FBXW9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M012799: view genomic region
(about GC identifiers)
Start:
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12,798,867 bp from pter |
End:
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12,807,457 bp from pter |
Size:
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8,591 bases |
Orientation:
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minus strand |
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Proteins
for FBXW9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBXW9_HUMAN, Q5XUX1 (See
protein sequence)Recommended Name: F-box/WD repeat-containing protein 9 Size: 488 amino acids; 54115 Da
Subunit: Interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: B3KVP7 Q9BT89Alternative splicing: 3 isoforms: Q5XUX1-1 Q5XUX1-2 Q5XUX1-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FBXW9: NX_Q5XUX1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5XUX1
FBXW9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115677.2
ENSEMBL proteins: ENSP00000465854 ENSP00000376945 ENSP00000465387 ENSP00000369696 ENSP00000442714 Reactome Protein details: Q5XUX1
Human Recombinant Protein Products:
FBXW9 Antibody Products:
Assay Products for FBXW9: |
Protein
Domains /
Families
for FBXW9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXW9 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5XUX1ProtoNet protein and cluster: Q5XUX1 UniProtKB/Swiss-Prot: FBXW9_HUMAN, Q5XUX1Similarity: Contains 1 F-box domainSimilarity: Contains 7 WD repeats |
Function
for FBXW9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBXW9_HUMAN, Q5XUX1Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FBXW9 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FBXW9:
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Pathways & Interactions
for FBXW9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chaperonin-mediated protein folding | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for FBXW9
FBXW9 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXW9
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for FBXW9 (Q5XUX11, 3 ENSP000003769454) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FBXW9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXW9
Search CenterWatch for drugs/clinical trials and news about FBXW9
|
Transcripts
for FBXW9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXW9 gene: NM_032301.2 Unigene Cluster for FBXW9: F-box and WD repeat domain containing 9 Hs.515154 [show with all ESTs]Unigene Representative Sequence: AK0932075 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587296 ENST00000393261(uc002mum.1) ENST00000587955 ENST00000380339(uc010dyx.2)
ENST00000544494(uc010xmp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXW9 (NM_032301) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW9 |
Additional cDNA sequence: AK093207.1 AK123037.1 AK302744.1 AY736034.1 BC004290.1 4 DOTS entries: DT.443280 DT.40250922 DT.75109093 DT.100790445 24/145 AceView cDNA sequences (see all 145): CA424584 BM977011 BM770561 BI913314 AX747991 AK093207 BM981266 BQ888622 CR606148 AK123037 BQ939958 CR618836 BM756899 BI771721 CB243761 NM_032301 BM756974 BI915435 BC004290 BM756887 CR595818 BI912680 BM925218 CR591156
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW9 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXW9
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Expression
for FBXW9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXW9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTGCTTG
About this image
See FBXW9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXW9
SOURCE GeneReport for Unigene cluster: Hs.515154
SABiosciences Expression via Pathway-Focused PCR Arrays including FBXW9: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat | | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXW9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW9 |
Orthologs
for FBXW9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXW9 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for FBXW9 (if available)
TreeFam Gene Tree for FBXW9 (if available) |
Paralogs
for FBXW9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FBXW9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXW9 (12798867 - 12807457 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FBXW9: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW9 |
|
Disorders
/ Diseases
for FBXW9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXW9 for disorders About GeneDecksing
OMIM gene information: 609074
OMIM disorders: --
1  disease for FBXW9: About MalaCardsneuronitis
Export disorders for FBXW9 gene to outside databases
|
Publications
for FBXW9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXW9 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FBXW9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1, 2 Jin J....Harper J.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for FBXW9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXW9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXW9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXW9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXW9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXW9 gene:
Search GeneIP for patents involving FBXW9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXW9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FBXW9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXW9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW9 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBXW9 | | OriGene 3'-UTR Clone for FBXW9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXW9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXW9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW9 |
| |
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| | | | Search Tocris compounds for FBXW9 |
| |  |  |  |  | | | | |
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 |
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 | | | FBXW9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW9 |
|  |  |  | | | | Search ThermoFisher Antibodies for FBXW9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW9 |
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