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FBXW9 Gene

protein-coding   GIFtS: 50
GCID: GC19M012799

F-Box And WD Repeat Domain Containing 9

(Previous name: F-box and WD-40 domain protein 9)
  See FBXW9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And WD Repeat Domain Containing 91 2     Fbw92
F-Box And WD-40 Domain Protein 91 2     F-Box And WD-40 Repeat Containing Protein 92
F-Box And WD-40 Domain-Containing Protein 92 3     F-Box/WD Repeat-Containing Protein 92
FBW93 5     Specificity Factor For SCF Ubiquitin Ligase2

External Ids:    HGNC: 281361   Entrez Gene: 842612   Ensembl: ENSG000001320047   OMIM: 6090745   UniProtKB: Q5XUX13   

Export aliases for FBXW9 gene to outside databases

Previous GC identifers: GC19M012661 GC19M012662 GC19M012372


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXW9 Gene:
Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXW9 Gene:
FBXW9 (F-box and WD repeat domain containing 9) is a protein-coding gene. Diseases associated with FBXW9 include mucoepidermoid carcinoma.

UniProtKB/Swiss-Prot: FBXW9_HUMAN, Q5XUX1
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXW9 gene promoter:
         Tal-1   p53   Nkx5-1   C/EBPalpha   Egr-4   Evi-1   E47   c-Ets-1   CHOP-10   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXW9 promoter sequence
   Search Chromatin IP Primers for FBXW9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXW9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

FBXW9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012799:  view genomic region     (about GC identifiers)

Start:
12,798,867 bp from pter      End:
12,807,457 bp from pter
Size:
8,591 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBXW9_HUMAN, Q5XUX1 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 9  
Size: 488 amino acids; 54115 Da
Subunit: Interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: B3KVP7 Q9BT89
Alternative splicing: 3 isoforms:  Q5XUX1-1   Q5XUX1-2   Q5XUX1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXW9: NX_Q5XUX1

Explore proteomics data for FBXW9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys215
  • Modification sites at PhosphoSitePlus

  • See FBXW9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115677.2  
    ENSEMBL proteins: 
     ENSP00000465854   ENSP00000376945   ENSP00000465387   ENSP00000369696   ENSP00000442714  
    Reactome Protein details: Q5XUX1

    FBXW9 Human Recombinant Protein Products:

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    Novus Biologicals FBXW9 Protein
    Novus Biologicals FBXW9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXW9

     
    Search eBioscience for Proteins for FBXW9 

    FBXW9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for FBXW9 at Abcam
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    Search ThermoFisher Antibodies for FBXW9
    LSBio Antibodies in human, mouse, rat for FBXW9

    FBXW9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for FBXW9
    Cloud-Clone Corp. CLIAs for FBXW9
    Search eBioscience for ELISAs for FBXW9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001810 F-box_dom
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q5XUX1

    ProtoNet protein and cluster: Q5XUX1

    UniProtKB/Swiss-Prot: FBXW9_HUMAN, Q5XUX1
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 WD repeats


    Find genes that share domains with FBXW9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXW9_HUMAN, Q5XUX1
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19159283
         
    Find genes that share ontologies with FBXW9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXW9:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Fbxw9 (no phenotypes)

    Find genes that share phenotypes with FBXW9           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXW9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXW9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXW9

    miRNA
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    Block miRNA regulation of human, mouse, rat FBXW9 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FBXW9:
    hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidFBXW9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXW9
    Predesigned siRNA for gene silencing in human, mouse, rat FBXW9

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW9 (NM_032301)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW9

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXW9 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXW9 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with FBXW9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FBXW9
        Association of TriC/CCT with target proteins during biosynthesis


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXW9: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXW9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for FBXW9 (Q5XUX11, 3 ENSP000003769454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 3, ENSP000002314874EBI-2322729,EBI-307486 I2D: score=1 STRING: ENSP00000231487
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    CDC6ENSP000002097284STRING: ENSP00000209728
    UBCENSP000003448184STRING: ENSP00000344818
    PSMD8ENSP000002150714STRING: ENSP00000215071
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA--

    Find genes that share ontologies with FBXW9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXW9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXW9 gene: 
    NM_032301.2  

    Unigene Cluster for FBXW9:

    F-box and WD repeat domain containing 9
    Hs.515154  [show with all ESTs]
    Unigene Representative Sequence: AK093207
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587296 ENST00000393261(uc002mum.1) ENST00000587955 ENST00000380339(uc010dyx.2)
    ENST00000544494(uc010xmp.2)
    miRNA
    Products:
         
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    4 qRT-PCR Assays for microRNAs that regulate FBXW9:
    hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidFBXW9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXW9
    Predesigned siRNA for gene silencing in human, mouse, rat FBXW9
    Clone
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    OriGene ORF clones in mouse, rat for FBXW9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW9 (NM_032301)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW9
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXW9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXW9
      QuantiTect SYBR Green Assays in human, mouse, rat FBXW9
      QuantiFast Probe-based Assays in human, mouse, rat FBXW9

    Additional mRNA sequence: 

    AK093207.1 AK123037.1 AK302744.1 AY736034.1 BC004290.1 

    4 DOTS entries:

    DT.443280  DT.40250922  DT.75109093  DT.100790445 

    Selected AceView cDNA sequences (see all 145):

    BM756887 CR618836 BQ888622 NM_032301 BI771721 BQ675825 BQ670148 BI915435 
    CA428908 CR614519 CR606148 BI913314 CR608192 BU621988 BM977011 BQ939958 
    CB243761 BM756899 BI912680 AX747991 CR618672 BM981266 BM925218 CR591156 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW9    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                                  -                                                         
    SP2:                    -                                                                                       
    SP3:                          -                       -                                                         
    SP4:                                                  -           -                                             


    ECgene alternative splicing isoforms for FBXW9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXW9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTGCTTG
    FBXW9 Expression
    About this image

    FBXW9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXW9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515154
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXW9: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FBXW9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXW9 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw91 , 5 F-box and WD-40 domain protein 91, 5 80.2(n)1
    77.51(a)1
      8 (41.54 cM)5
    686281  NM_026791.21  NP_081067.21 
     850600555 
    lizard
    (Anolis carolinensis)
    Reptilia FBXW96
    F-box and WD repeat domain containing 9
    56(a)
    1 ↔ 1
    GL343286.1(757964-768737)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.107432 Transcribed sequence with weak similarity to protein more 72.17(n)    BX739884.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxw91 F-box and WD repeat domain containing 9 58.48(n)
    47.75(a)
      100330184  XM_002661103.2  XP_002661149.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mec-151 mec-15 41.75(n)
    31.74(a)
      174587  NM_063806.6  NP_496207.1 


    ENSEMBL Gene Tree for FBXW9 (if available)
    TreeFam Gene Tree for FBXW9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXW9 (see all 234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs759293151,2
    C,F--12799764(+) TCCTTC/TGCTCT 1 -- ut311Minor allele frequency- T:0.10WA 118
    rs1867544371,2
    --12799915(+) GGACTC/GCTTGT 1 -- ut310--------
    rs1129871541,2
    C--12799997(+) GCCTCC/TGGCAG 1 -- ut311Minor allele frequency- T:0.01EU 443
    rs1443897071,2
    C,F--12800062(+) CGACAG/AGTCTC 2 /L syn12Minor allele frequency- A:0.00NA EU 5515
    rs2005925231,2
    C--12800109(+) CCTGGA/GAAGGG 1 -- int10--------
    rs1434262781,2
    C--12800156(+) GCCAGC/GTGGGC 1 -- int10--------
    rs2021874201,2
    C--12800204(+) TTGTCA/GTGCCT 2 H syn10--------
    rs1468373771,2
    C,F--12800212(+) CCTTCG/AGGTGC 2 /R /* stg11Minor allele frequency- A:0.00NA 4544
    rs2012214151,2
    --12800306(+) AGGTAA/GGGGAG 1 -- int10--------
    rs1440315581,2
    C,F--12800396(+) TCCCAC/TGGAGT 2 M V mis12Minor allele frequency- T:0.01NA EU 5649

    HapMap Linkage Disequilibrium report for FBXW9 (12798867 - 12807457 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXW9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911077CNV Loss21882294
    dgv3733n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXW9
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXW9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609074    OMIM disorders: --

    1 disease for FBXW9:    
    About MalaCards
    mucoepidermoid carcinoma

    1 disease from the University of Copenhagen DISEASES database for FBXW9:
    Mucoepidermoid carcinoma

    Find genes that share disorders with FBXW9           About GenesLikeMe


    Export disorders for FBXW9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXW9 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FBXW9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1, 2 Jin J....Harper J.W. (Genes Dev. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    10. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (J. Proteome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84261 HGNC: 28136 AceView: FBXW9 Ensembl:ENSG00000132004 euGenes: HUgn84261
    ECgene: FBXW9 H-InvDB: FBXW9

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXW9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXW9 gene:
    Search GeneIP for patents involving FBXW9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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