Aliases for FBXW8 Gene
Aliases for FBXW8 Gene
External Ids for FBXW8 Gene
- HGNC: 13597
- Entrez Gene: 26259
- Ensembl: ENSG00000174989
- OMIM: 609073
- UniProtKB: Q8N3Y1
Previous HGNC Symbols for FBXW8 Gene
- FBXO29
Previous GeneCards Identifiers for FBXW8 Gene
- GC12P117131
- GC12P115760
- GC12P115811
- GC12P117348
- GC12P114357
Summaries for FBXW8 Gene
-
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXW8 Gene
FBXW8 (F-Box And WD Repeat Domain Containing 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for FBXW8 Gene
-
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW8 Gene
Genomics for FBXW8 Gene
Regulatory Elements for FBXW8 Gene
Enhancers for FBXW8 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G116492 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 43 | -415.7 | -415721 | 5.4 | HDGF PKNOX1 CREB3L1 ARNT SIN3A ZBTB7B ZNF766 CBX5 ZNF207 FOS | FBXW8 MED13L ENSG00000258034 LINC00173 MAP1LC3B2 LOC105370007 LOC105370008 |
| GH12G116915 | 1.4 | Ensembl ENCODE | 51.8 | +5.5 | 5546 | 2.2 | HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 YBX1 ZNF2 ZNF416 | FBXW8 MED13L ENSG00000274554 |
| GH12G116243 | 1.4 | Ensembl ENCODE dbSUPER | 35.1 | -666.4 | -666351 | 2.0 | ZFP64 FEZF1 YY1 ZNF121 ZNF366 ZSCAN5C KLF7 ZNF202 ZBTB11 CEBPB | FBXW8 MED13L GC12P116232 |
| GH12G117070 | 1.4 | Ensembl ENCODE dbSUPER | 19.4 | +159.3 | 159341 | 1.4 | HDAC1 HDGF NFIB FEZF1 ZNF766 EGR1 EGR2 SMARCA5 NCOA1 ZNF488 | FBXW8 RFC5 TESC-AS1 GC12M117031 |
| GH12G117189 | 1 | ENCODE | 26.9 | +279.0 | 278996 | 2.3 | PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 ZNF548 SP3 | FBXW8 FBXO21 MED13L LOC105370010 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXW8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXW8 gene promoter:
Regulatory Element Products
Genomic Location for FBXW8 Gene
- Chromosome:
- 12
- Start:
- 116,910,951 bp from pter
- End:
- 117,032,498 bp from pter
- Size:
- 121,548 bases
- Orientation:
- Plus strand
Genomic View for FBXW8 Gene
Genes around FBXW8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.22 by Ensembl
- 12q24.22 by Entrez Gene
- 12q24.22 by HGNC
FBXW8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXW8 Gene
Proteins for FBXW8 Gene
-
Protein details for FBXW8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N3Y1-FBXW8_HUMAN
- Recommended name:
- F-box/WD repeat-containing protein 8
- Protein Accession:
- Q8N3Y1
- Q9UK95
Protein attributes for FBXW8 Gene
- Size:
- 598 amino acids
- Molecular mass:
- 67394 Da
- Quaternary structure:
-
- Part of a Cul7-RING ubiquitin-protein ligase complex, consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with GLMN isoform 1. Interacts with CUL7. Interacts with OBSL1, CUL1, CUL2, SKP1, CCT6B, PFDN5, CCT2, CCT3, CCT6A, CCT7, VBP1, CCDC8, ARF1, TRIP13, PDCD5 and GORASP1. Interacts with IRS1 (when phosphorylated). Interacts with MAP4K1/HPK1 (when autophosphorylated). Associated component of the 3M complex.
- SequenceCaution:
-
- Sequence=AAF03129.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF03129.1; Type=Frameshift; Positions=282, 295; Evidence={ECO:0000305};
Protein Expression for FBXW8 Gene
Post-translational modifications for FBXW8 Gene
Other Protein References for FBXW8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam proteins for FBXW8
Assay Products
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No data available for DME Specific Peptides for FBXW8 Gene
Domains & Families for FBXW8 Gene
Gene Families for FBXW8 Gene
Protein Domains for FBXW8 Gene
Suggested Antigen Peptide Sequences for FBXW8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXW8 Gene
Function for FBXW8 Gene
Molecular function for FBXW8 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 15070733 |
Phenotypes for FBXW8 Gene
- MGI mutant phenotypes for FBXW8:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FBXW8:
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miRNA for FBXW8 Gene
- miRTarBase miRNAs that target FBXW8
-
- hsa-mir-665 (MIRT633366)
- hsa-mir-6513-5p (MIRT633367)
- hsa-mir-887-5p (MIRT633368)
- hsa-mir-3913-5p (MIRT633369)
- hsa-mir-3122 (MIRT633370)
- hsa-mir-450a-1-3p (MIRT633371)
- hsa-mir-1304-5p (MIRT633372)
- hsa-mir-6780a-5p (MIRT633373)
- hsa-mir-6779-5p (MIRT633374)
- hsa-mir-3689c (MIRT633375)
- hsa-mir-3689b-3p (MIRT633376)
- hsa-mir-3689a-3p (MIRT633377)
- hsa-mir-30b-3p (MIRT633378)
- hsa-mir-1273h-5p (MIRT633379)
- hsa-mir-6788-5p (MIRT633380)
- hsa-mir-30c-2-3p (MIRT633381)
- hsa-mir-30c-1-3p (MIRT633382)
- hsa-mir-664b-3p (MIRT633383)
- hsa-mir-579-3p (MIRT633384)
- hsa-mir-6799-5p (MIRT633385)
- hsa-mir-6883-5p (MIRT633386)
- hsa-mir-6785-5p (MIRT633387)
- hsa-mir-4728-5p (MIRT633388)
- hsa-mir-149-3p (MIRT633389)
- hsa-mir-7106-5p (MIRT633390)
- hsa-mir-7160-5p (MIRT633391)
- hsa-mir-6884-5p (MIRT633392)
- hsa-mir-485-5p (MIRT633393)
- hsa-mir-1827 (MIRT633394)
- hsa-mir-4649-3p (MIRT633395)
- hsa-mir-4742-5p (MIRT633396)
- hsa-mir-4478 (MIRT633397)
- hsa-mir-4419b (MIRT633398)
- hsa-mir-3929 (MIRT633399)
- hsa-mir-940 (MIRT633400)
- hsa-mir-6893-5p (MIRT633401)
- hsa-mir-6808-5p (MIRT633402)
- hsa-mir-6842-3p (MIRT643220)
- hsa-mir-647 (MIRT643221)
- hsa-mir-5001-3p (MIRT643222)
- hsa-mir-6762-3p (MIRT643223)
- hsa-mir-604 (MIRT643224)
- hsa-mir-6781-3p (MIRT643225)
- hsa-mir-2682-3p (MIRT643226)
- hsa-mir-1304-3p (MIRT643227)
- hsa-mir-6890-3p (MIRT643228)
miRNA Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXW8 Gene
Localization for FBXW8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXW8 Gene
- Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA,IEA | 21572988 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IEA | -- |
| GO:0031467 | Cul7-RING ubiquitin ligase complex | IDA | 18498745 |
Pathways & Interactions for FBXW8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Ubiquitin mediated proteolysis | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for FBXW8 Gene
4 Reactome pathways for FBXW8 Gene
1 KEGG pathway for FBXW8 Gene
UniProtKB/Swiss-Prot Q8N3Y1-FBXW8_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXW8 Gene
Selected Interacting proteins:
Q8N3Y1-FBXW8_HUMAN
ENSP00000310686
for FBXW8 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0007030 | Golgi organization | ISS | -- |
| GO:0008283 | cell proliferation | IDA | 24362026 |
| GO:0016567 | protein ubiquitination | IDA,IEA | 18498745 |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXW8 Gene
Transcripts for FBXW8 Gene
mRNA/cDNA for FBXW8 Gene
- (8) REFSEQ mRNAs :
- (88) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for FBXW8 Gene
This gene is overexpressed in Adipocyte (15.0), Lung (14.6), Placenta (11.0), and Fetal ovary (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXW8 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXW8 Gene:
FBXW8SOURCE GeneReport for Unigene cluster for FBXW8 Gene:
Hs.624537Evidence on tissue expression from TISSUES for FBXW8 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXW8
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OriGene qPCR primer pairs for FBXW8
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW8 Gene
Orthologs for FBXW8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXW8 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RNFT2 34 |
|
||
| FBXW8 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | FBXW8 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxw8 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxw8 16 35 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXW8 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXW8 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXW8 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXW8 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxw8 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.17133 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxw8 34 35 |
|
- Species where no ortholog for FBXW8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXW8 Gene
No data available for Paralogs for FBXW8 Gene
Variants for FBXW8 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016569 | -- | 116,991,084(+) | TTCTA(A/C)ATGTC | intron-variant | |
| rs1000024428 | -- | 117,000,915(+) | TGACA(C/T)GAGCT | intron-variant | |
| rs1000024647 | -- | 116,991,472(+) | AATTC(C/G)CAAAT | intron-variant | |
| rs1000027236 | -- | 116,947,451(+) | CTTAT(C/G)AAAAC | intron-variant | |
| rs1000028194 | -- | 117,030,935(+) | AGTTT(C/T)TAGCC | nc-transcript-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1562n100 | CNV | gain | 25217958 |
| esv2746432 | CNV | deletion | 23290073 |
| esv3549840 | CNV | deletion | 23714750 |
| esv3630861 | CNV | loss | 21293372 |
| nsv519118 | CNV | loss | 19592680 |
| nsv832524 | CNV | gain | 17160897 |
| nsv900 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.87;
58.96% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXW8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXW8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW8 Gene
Disorders for FBXW8 Gene
Relevant External Links for FBXW8
No disorders were found for FBXW8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW8 Gene
Publications for FBXW8 Gene
- A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 64
- The 3M complex maintains microtubule and genome integrity. (PMID: 24793695) Yan J. … Xiong Y. (Mol. Cell 2014) 3 4 64
- The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. (PMID: 24362026) Wang H. … Wang H. (J. Biol. Chem. 2014) 3 4 64
- An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. (PMID: 21572988) Litterman N. … Bonni A. (PLoS Biol. 2011) 3 4 64
- The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. (PMID: 18498745) Xu X. … Pan Z.Q. (Mol. Cell 2008) 3 4 64
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- Santa Cruz Biotechnology (SCBT) Antibodies for FBXW8
- Search Santa Cruz Biotechnology (SCBT) for FBXW8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FBXW8
- Horizon Cell Lines for FBXW8
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXW8
- VectorBuilder custom plasmid, inducible vectors for FBXW8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXW8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXW8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer