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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXW8 Gene

protein-coding   GIFtS: 53
GCID: GC12P117348

F-Box And WD Repeat Domain Containing 8

(Previous names: F-box only protein 29, F-box and WD-40 domain protein 8)
(Previous symbol: FBXO29)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And WD Repeat Domain Containing 81 2     FBX292 3 5
FBXO291 2 3 5     FBXW62 3 5
F-Box Only Protein 291 2 3     F-Box And WD-40 Domain Protein 81 2
FBW62 3 5     F-Box And WD-40 Domain-Containing Protein 82 3
FBW82 3 5     F-Box/WD Repeat-Containing Protein 82

External Ids:    HGNC: 135971   Entrez Gene: 262592   Ensembl: ENSG000001749897   OMIM: 6090735   UniProtKB: Q8N3Y13   

Export aliases for FBXW8 gene to outside databases

Previous GC identifers: GC12P117131 GC12P115760 GC12P115811 GC12P114357


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXW8 Gene:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40
amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box
proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FBXW8 Gene: 
FBXW8 (F-box and WD repeat domain containing 8) is a protein-coding gene. Diseases associated with FBXW8 include 3-m syndrome, and skin tag, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: FBXW8_HUMAN, Q8N3Y1
Function: Substrate-recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins. In complex with CUL7, mediates
ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that
regulates Golgi morphogenesis and dendrite patterning in brain

Gene Wiki entry for FBXW8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXW8 gene promoter:
         AML1a   p53   AP-1   ATF-2   NF-kappaB   E47   Nkx6-1   Hand1   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXW8 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXW8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.22   Ensembl cytogenetic band:  12q24.22   HGNC cytogenetic band: 12q24.23

FBXW8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P117348:  view genomic region     (about GC identifiers)

Start:
117,348,761 bp from pter      End:
117,468,953 bp from pter
Size:
120,193 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXW8_HUMAN, Q8N3Y1 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 8  
Size: 598 amino acids; 67394 Da
Subunit: Part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Interacts with CUL7.
Interacts with OBSL1, CUL1, CUL2, SKP1, CCT6B, PFDN5, CCT2, CCT3, CCT6A, CCT7, VBP1, CCDC8, ARF1, TRIP13, PDCD5
and GORASP1
Subcellular location: Cytoplasm, perinuclear region. Golgi apparatus. Note=Co-localizes with CUL7 at the Golgi
apparatus in neurons (By similarity)
Sequence caution: Sequence=AAF03129.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAF03129.1; Type=Frameshift; Positions=282, 295;
Secondary accessions: Q9UK95
Alternative splicing: 2 isoforms:  Q8N3Y1-1   Q8N3Y1-2   

Explore the universe of human proteins at neXtProt for FBXW8: NX_Q8N3Y1

Explore proteomics data for FBXW8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N3Y1

  • FBXW8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXW8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_036306.1  NP_699179.2  

    ENSEMBL proteins: 
     ENSP00000310686   ENSP00000389144  
    Reactome Protein details: Q8N3Y1
    Human Recombinant Protein Products for FBXW8: 
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    Cloud-Clone Corp. Proteins for FBXW8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA--
    GO:0019005SCF ubiquitin ligase complex IEA--
    GO:0031467Cul7-RING ubiquitin ligase complex IDA--
    GO:0048471perinuclear region of cytoplasm IDA--

    FBXW8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001810 F-box_dom_cyclin-like
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q8N3Y1

    ProtoNet protein and cluster: Q8N3Y1

    UniProtKB/Swiss-Prot: FBXW8_HUMAN, Q8N3Y1
    Similarity: Contains 1 F-box domain
    Similarity: Contains 5 WD repeats


    FBXW8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXW8_HUMAN, Q8N3Y1
    Function: Substrate-recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the
    ubiquitination and subsequent proteasomal degradation of target proteins. In complex with CUL7, mediates
    ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that
    regulates Golgi morphogenesis and dendrite patterning in brain

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17314511
         
    FBXW8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXW8:
     Increased S DNA content  Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fbxw8):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system  respiratory system  skeleton 

    FBXW8 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXW8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for FBXW8
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for FBXW8):
        Ubiquitin mediated proteolysis


    FBXW8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXW8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/103 Interacting proteins for FBXW8 (Q8N3Y11, 2, 3 ENSP000003106864) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011061, 3, ENSP000003672074EBI-914770,EBI-447544 I2D: score=3 STRING: ENSP00000367207
    RBX1P628772, 3, ENSP000002162254MINT-8415355 I2D: score=2 STRING: ENSP00000216225
    CUL7Q149992, 3, ENSP000002653484MINT-8415355 I2D: score=4 STRING: ENSP00000265348
    SKP1P632082, 3, ENSP000002314874MINT-8415355 I2D: score=3 STRING: ENSP00000231487
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization ISS--
    GO:0050775positive regulation of dendrite morphogenesis ISS--
    GO:0060712spongiotrophoblast layer development IEA--
    GO:0060716labyrinthine layer blood vessel development IEA--

    FBXW8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXW8

    Search CenterWatch for drugs/clinical trials and news about FBXW8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXW8 gene (2 alternative transcripts): 
    NM_012174.1  NM_153348.2  

    Unigene Clusters for FBXW8:

    F-box and WD repeat domain containing 8
    Hs.624537 , Hs.696428  [show with all ESTs]
    Unigene Representative Sequences: BC045190, NM_153348
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309909 ENST00000455858(uc001twf.1 uc001twg.1) ENST00000551773

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    Additional mRNA sequence: 

    AF176707.1 AK055849.1 AK289621.1 BC037296.2 

    7 DOTS entries:

    DT.100718948  DT.454238  DT.121137959  DT.100776795  DT.121137976  DT.91742898  DT.95321058 

    2 AceView cDNA sequences:

    BI561089 BC045190 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW8    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                      -                 -     -                                                   
    SP2:                    -                 -                 -     -                                                   
    SP3:                    -                 -     -           -     -                                                   
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for FBXW8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXW8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCAGGGG
    FBXW8 Expression
    About this image


    See FBXW8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXW8

    SOURCE GeneReport for Unigene clusters: Hs.624537 Hs.696428
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXW8 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw81 , 5 F-box and WD-40 domain protein 81, 5 81.43(n)1
    79.03(a)1
      5 (57.92 cM)5
    2316721  NM_172721.21  NP_766309.21 
     1180649815 
    chicken
    (Gallus gallus)
    Aves FBXW81 F-box and WD repeat domain containing 8 67.78(n)
    61.55(a)
      417024  XM_415314.2  XP_415314.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXW86
    Uncharacterized protein
    58(a)
    1 ↔ 1
    LGb(2339025-2372226)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.171332 Xenopus laevis transcribed sequences 77.34(n)    CA793060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxw81 F-box and WD repeat domain containing 8 54.37(n)
    44.73(a)
      100136859  NM_001114578.1  NP_001108050.1 


    ENSEMBL Gene Tree for FBXW8 (if available)
    TreeFam Gene Tree for FBXW8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2285 SNPs in FBXW8 are shown (see all 2285)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855904891,2
    --117346863(+) ATTGCC/TACAGT 2 -- us2k10--------
    rs1420759821,2
    --117346931(+) CTGTCA/GCCCAA 2 -- us2k10--------
    rs1501020941,2
    C--117346936(+) GCCCAA/GGCTGG 2 -- us2k10--------
    rs559267321,2
    --117346962(+) ATATAC/TGCCCA 2 -- us2k10--------
    rs1881039061,2
    --117346970(+) CCAACC/TATATA 2 -- us2k10--------
    rs118379181,2
    C,H--117347173(+) cacacC/Gtgtaa 2 -- us2k10--------
    rs44518161,2
    C,F,A--117347186(+) ccagcG/Actttg 2 -- us2k14Minor allele frequency- A:0.43WA CSA 7
    rs1809780111,2
    C--117347284(+) AAAAAA/CTTAGC 2 -- us2k10--------
    rs615630451,2
    C--117347302(+) GGTGGC/TGGGCA 2 -- us2k10--------
    rs1869845831,2
    --117347333(+) GGAGGC/TTGAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXW8 (117348761 - 117468953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FBXW8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746432CNV Deletion23290073
    nsv900CNV Insertion18451855
    nsv899541CNV Loss21882294
    nsv519118CNV Loss19592680
    nsv832524CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609073    OMIM disorders: --

    4 diseases for FBXW8:    About MalaCards
    3-m syndrome    skin tag    multiple myeloma    myeloma


    FBXW8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXW8

    Export disorders for FBXW8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXW8 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with FBXW8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T....Harper J.W. (1999)
    2. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechani sm regulates Golgi morphology and dendrite patterning. (PubMed id 21572988)1, 2 Litterman N....Bonni A. (2011)
    3. PARC and CUL7 form atypical cullin RING ligase complexes. (PubMed id 17332328)1, 2 Skaar J.R.... DeCaprio J.A. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PubMed id 12481031)1, 2 Dias D.C.... Pan Z.Q. (2002)
    6. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 3 Cenciarelli C....Pagano M. (1999)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. Ubiquitination and degradation of the hominoid-specifi c oncoprotein TBC1D3 is mediated by CUL7 E3 ligase. (PubMed id 23029530)1 Kong C....Stahl P.D. (2012)
    9. Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restrictio n? (PubMed id 22524683)1 Fahlbusch F.B....Dotsch J. (2012)
    10. Fbxw7a- and GSK3-mediated degradation of p100 is a pro -survival mechanism in multiple myeloma. (PubMed id 22388891)1 Busino L....Pagano M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26259 HGNC: 13597 AceView: FBXW8.1 Ensembl:ENSG00000174989 euGenes: HUgn26259
    ECgene: FBXW8 Kegg: 26259 H-InvDB: FBXW8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXW8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXW8 gene:
    Search GeneIP for patents involving FBXW8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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