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Aliases for FBXW8 Gene

Aliases for FBXW8 Gene

  • F-Box And WD Repeat Domain Containing 8 2 3
  • F-Box Only Protein 29 2 3 4
  • FBXO29 3 4 6
  • FBXW6 3 4 6
  • FBX29 3 4 6
  • FBW6 3 4 6
  • FBW8 3 4 6
  • F-Box And WD-40 Domain-Containing Protein 8 3 4
  • F-Box And WD-40 Domain Protein 8 2 3
  • F-Box/WD Repeat-Containing Protein 8 3

External Ids for FBXW8 Gene

Previous Symbols for FBXW8 Gene

  • FBXO29

Summaries for FBXW8 Gene

Entrez Gene Summary for FBXW8 Gene

  • This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW8 Gene

FBXW8 (F-Box And WD Repeat Domain Containing 8) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for FBXW8 Gene

  • Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).

Gene Wiki entry for FBXW8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW8 Gene

Genomics for FBXW8 Gene

Genomic Location for FBXW8 Gene

Start:
116,910,951 bp from pter
End:
117,031,148 bp from pter
Size:
120,198 bases
Orientation:
Plus strand

Genomic View for FBXW8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXW8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW8 Gene

Regulatory Elements for FBXW8 Gene

Proteins for FBXW8 Gene

  • Protein details for FBXW8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3Y1-FBXW8_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 8
    Protein Accession:
    Q8N3Y1
    Secondary Accessions:
    • Q9UK95

    Protein attributes for FBXW8 Gene

    Size:
    598 amino acids
    Molecular mass:
    67394 Da
    Quaternary structure:
    • Part of a Cul7-RING ubiquitin-protein ligase complex, consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with GLMN isoform 1. Interacts with CUL7. Interacts with OBSL1, CUL1, CUL2, SKP1, CCT6B, PFDN5, CCT2, CCT3, CCT6A, CCT7, VBP1, CCDC8, ARF1, TRIP13, PDCD5 and GORASP1. Interacts with IRS1 (when phosphorylated). Interacts with MAP4K1/HPK1 (when autophosphorylated). Associated component of the 3M complex.
    SequenceCaution:
    • Sequence=AAF03129.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF03129.1; Type=Frameshift; Positions=282, 295; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW8 Gene

Proteomics data for FBXW8 Gene at MOPED

Post-translational modifications for FBXW8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys427

Other Protein References for FBXW8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXW8 Gene

Domains for FBXW8 Gene

Gene Families for FBXW8 Gene

HGNC:
  • WDR :WD repeat domain containing
  • FBXW :F-boxes / WD-40 domains

UniProtKB/Swiss-Prot:

FBXW8_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q8N3Y1
Similarity:
  • Contains 5 WD repeats.:
    • Q8N3Y1
genes like me logo Genes that share domains with FBXW8: view

Function for FBXW8 Gene

Molecular function for FBXW8 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).

Gene Ontology (GO) - Molecular Function for FBXW8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 24362026
GO:0005515 protein binding IPI 17314511
genes like me logo Genes that share ontologies with FBXW8: view
genes like me logo Genes that share phenotypes with FBXW8: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXW8 Gene

Localization for FBXW8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXW8 Gene

Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXW8 Gene COMPARTMENTS Subcellular localization image for FBXW8 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FBXW8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA 21572988
GO:0019005 SCF ubiquitin ligase complex IEA --
GO:0031467 Cul7-RING ubiquitin ligase complex IDA 18498745
GO:0048471 perinuclear region of cytoplasm IDA 21572988
genes like me logo Genes that share ontologies with FBXW8: view

Pathways for FBXW8 Gene

genes like me logo Genes that share pathways with FBXW8: view

UniProtKB/Swiss-Prot Q8N3Y1-FBXW8_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXW8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization ISS --
GO:0008283 cell proliferation IDA 24362026
GO:0016567 protein ubiquitination IEA --
GO:0050775 positive regulation of dendrite morphogenesis ISS --
GO:0060712 spongiotrophoblast layer development IEA --
genes like me logo Genes that share ontologies with FBXW8: view

Transcripts for FBXW8 Gene

mRNA/cDNA for FBXW8 Gene

(6) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for FBXW8 Gene

GeneLoc Exon Structure for
FBXW8
ECgene alternative splicing isoforms for
FBXW8

Expression for FBXW8 Gene

mRNA expression in normal human tissues for FBXW8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXW8 Gene

SOURCE GeneReport for Unigene cluster for FBXW8 Gene Hs.624537

genes like me logo Genes that share expressions with FBXW8: view

Orthologs for FBXW8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXW8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW8 36
  • 99.55 (n)
  • 99.66 (a)
FBXW8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXW8 36
  • 87.21 (n)
  • 86.53 (a)
FBXW8 37
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXW8 37
  • 79 (a)
OneToOne
RNFT2 36
  • 87.5 (n)
  • 88.32 (a)
mouse
(Mus musculus)
Mammalia Fbxw8 36
  • 81.07 (n)
  • 78.22 (a)
Fbxw8 16
Fbxw8 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXW8 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXW8 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxw8 36
  • 81.15 (n)
  • 78.12 (a)
chicken
(Gallus gallus)
Aves FBXW8 36
  • 67.61 (n)
  • 61.09 (a)
FBXW8 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXW8 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17133 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw8 36
  • 58.33 (n)
  • 50.17 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxw8 36
  • 56.47 (n)
  • 47.2 (a)
fbxw8 37
  • 41 (a)
OneToOne
Species with no ortholog for FBXW8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW8 Gene

ENSEMBL:
Gene Tree for FBXW8 (if available)
TreeFam:
Gene Tree for FBXW8 (if available)

Paralogs for FBXW8 Gene

No data available for Paralogs for FBXW8 Gene

Variants for FBXW8 Gene

Sequence variations from dbSNP and Humsavar for FBXW8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3541 -- 117,010,018(+) CGGCT(C/T)TCTCT intron-variant
rs937567 -- 117,021,158(-) ctacc(C/G)agcaa intron-variant
rs952934 -- 117,005,277(+) GGCAT(C/T)GTGTA intron-variant
rs1051877 -- 117,029,239(+) TCCCC(C/T)AACCC utr-variant-3-prime
rs1051879 -- 117,029,320(+) GAATA(A/G)TGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXW8 Gene

Variant ID Type Subtype PubMed ID
nsv832524 CNV Gain 17160897
nsv519118 CNV Loss 19592680
nsv900 CNV Insertion 18451855
nsv899541 CNV Loss 21882294
esv2746432 CNV Deletion 23290073

Relevant External Links for FBXW8 Gene

HapMap Linkage Disequilibrium report
FBXW8

Disorders for FBXW8 Gene

Relevant External Links for FBXW8

Genetic Association Database (GAD)
FBXW8
genes like me logo Genes that share disorders with FBXW8: view

No data available for UniProtKB/Swiss-Prot for FBXW8 Gene

Publications for FBXW8 Gene

  1. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4
  2. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PMID: 12481031) Dias D.C. … Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. (PMID: 21572988) Litterman N. … Bonni A. (PLoS Biol. 2011) 3 4
  5. The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. (PMID: 18498745) Xu X. … Pan Z.Q. (Mol. Cell 2008) 3 4

Products for FBXW8 Gene

Sources for FBXW8 Gene

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