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Aliases for FBXW8 Gene

Aliases for FBXW8 Gene

  • F-Box And WD Repeat Domain Containing 8 2 3 5
  • F-Box Only Protein 29 2 3 4
  • F-Box And WD-40 Domain-Containing Protein 8 3 4
  • F-Box And WD-40 Domain Protein 8 2 3
  • FBXO29 3 4
  • FBXW6 3 4
  • FBX29 3 4
  • FBW6 3 4
  • FBW8 3 4
  • F-Box/WD Repeat-Containing Protein 8 3

External Ids for FBXW8 Gene

Previous HGNC Symbols for FBXW8 Gene

  • FBXO29

Previous GeneCards Identifiers for FBXW8 Gene

  • GC12P117131
  • GC12P115760
  • GC12P115811
  • GC12P117348
  • GC12P114357

Summaries for FBXW8 Gene

Entrez Gene Summary for FBXW8 Gene

  • This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW8 Gene

FBXW8 (F-Box And WD Repeat Domain Containing 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXW8 Gene

  • Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).

Gene Wiki entry for FBXW8 Gene

Additional gene information for FBXW8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW8 Gene

Genomics for FBXW8 Gene

GeneHancer (GH) Regulatory Elements for FBXW8 Gene

Promoters and enhancers for FBXW8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I116910 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565.6 +0.3 328 1.8 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B E2F8 ZNF207 FBXW8 ENSG00000274554
GH12I116492 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 89 -415.7 -415720 5.4 HDGF PKNOX1 ARNT NEUROD1 SIN3A ZBTB7B ZNF766 CBX5 E2F8 ZNF207 FBXW8 MED13L ENSG00000258034 FBXO21 LINC00173 MAP1LC3B2 LOC105370007 LOC105370008
GH12I116915 Enhancer 1.3 Ensembl ENCODE 87.7 +5.5 5545 2.2 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 IRF4 FBXW8 MED13L FBXO21 ENSG00000258034 ENSG00000274554
GH12I116735 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 42 -173.6 -173637 3 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D GLIS1 RNFT2 C12orf49 FBXW8 MED13L ENSG00000258034 MAP1LC3B2 PIR60746
GH12I116121 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 49.5 -788.1 -788103 3.5 PKNOX1 ARNT SIN3A FEZF1 ZNF2 IRF4 ATF7 RUNX3 ZNF214 ZNF202 FBXW8 MAP1LC3B2 MED13L MIR620 ENSG00000258034 GC12M116089 GC12P116137
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXW8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXW8 gene promoter:

Genomic Locations for FBXW8 Gene

Genomic Locations for FBXW8 Gene
chr12:116,910,951-117,032,498
(GRCh38/hg38)
Size:
121,548 bases
Orientation:
Plus strand
chr12:117,348,761-117,468,953
(GRCh37/hg19)

Genomic View for FBXW8 Gene

Genes around FBXW8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW8 Gene

Proteins for FBXW8 Gene

  • Protein details for FBXW8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3Y1-FBXW8_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 8
    Protein Accession:
    Q8N3Y1
    Secondary Accessions:
    • Q9UK95

    Protein attributes for FBXW8 Gene

    Size:
    598 amino acids
    Molecular mass:
    67394 Da
    Quaternary structure:
    • Part of a Cul7-RING ubiquitin-protein ligase complex, consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with GLMN isoform 1. Interacts with CUL7. Interacts with OBSL1, CUL1, CUL2, SKP1, CCT6B, PFDN5, CCT2, CCT3, CCT6A, CCT7, VBP1, CCDC8, ARF1, TRIP13, PDCD5 and GORASP1. Interacts with IRS1 (when phosphorylated). Interacts with MAP4K1/HPK1 (when autophosphorylated). Associated component of the 3M complex.
    SequenceCaution:
    • Sequence=AAF03129.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF03129.1; Type=Frameshift; Positions=282, 295; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW8 Gene

Post-translational modifications for FBXW8 Gene

No data available for DME Specific Peptides for FBXW8 Gene

Domains & Families for FBXW8 Gene

Gene Families for FBXW8 Gene

Suggested Antigen Peptide Sequences for FBXW8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXW8: view

No data available for UniProtKB/Swiss-Prot for FBXW8 Gene

Function for FBXW8 Gene

Molecular function for FBXW8 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).

Phenotypes From GWAS Catalog for FBXW8 Gene

Gene Ontology (GO) - Molecular Function for FBXW8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 15070733
genes like me logo Genes that share ontologies with FBXW8: view
genes like me logo Genes that share phenotypes with FBXW8: view

Animal Models for FBXW8 Gene

MGI Knock Outs for FBXW8:

miRNA for FBXW8 Gene

miRTarBase miRNAs that target FBXW8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXW8 Gene

Localization for FBXW8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXW8 Gene

Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW8 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXW8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA,IDA 21572988
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IEA --
GO:0031467 Cul7-RING ubiquitin ligase complex IDA 18498745
genes like me logo Genes that share ontologies with FBXW8: view

Pathways & Interactions for FBXW8 Gene

genes like me logo Genes that share pathways with FBXW8: view

UniProtKB/Swiss-Prot Q8N3Y1-FBXW8_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXW8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0007030 Golgi organization ISS --
GO:0008283 cell proliferation IDA 24362026
GO:0016567 protein ubiquitination IDA,IEA 18498745
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXW8: view

No data available for SIGNOR curated interactions for FBXW8 Gene

Drugs & Compounds for FBXW8 Gene

No Compound Related Data Available

Transcripts for FBXW8 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for FBXW8 Gene

GeneLoc Exon Structure for
FBXW8
ECgene alternative splicing isoforms for
FBXW8

Expression for FBXW8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXW8 Gene

Protein differential expression in normal tissues from HIPED for FBXW8 Gene

This gene is overexpressed in Adipocyte (15.0), Lung (14.6), Placenta (11.0), and Fetal ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXW8 Gene



Protein tissue co-expression partners for FBXW8 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXW8 Gene:

FBXW8

SOURCE GeneReport for Unigene cluster for FBXW8 Gene:

Hs.624537

Evidence on tissue expression from TISSUES for FBXW8 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FBXW8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW8 Gene

Orthologs for FBXW8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXW8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW8 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia RNFT2 33
  • 87.5 (n)
FBXW8 34
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXW8 33 34
  • 87.21 (n)
rat
(Rattus norvegicus)
Mammalia Fbxw8 33
  • 81.15 (n)
mouse
(Mus musculus)
Mammalia Fbxw8 33 16 34
  • 81.07 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXW8 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXW8 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXW8 33 34
  • 67.61 (n)
lizard
(Anolis carolinensis)
Reptilia FBXW8 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw8 33
  • 58.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17133 33
zebrafish
(Danio rerio)
Actinopterygii fbxw8 33 34
  • 56.47 (n)
Species where no ortholog for FBXW8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW8 Gene

ENSEMBL:
Gene Tree for FBXW8 (if available)
TreeFam:
Gene Tree for FBXW8 (if available)

Paralogs for FBXW8 Gene

No data available for Paralogs for FBXW8 Gene

Variants for FBXW8 Gene

Sequence variations from dbSNP and Humsavar for FBXW8 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000016569 -- 116,991,084(+) A/C intron_variant
rs1000024428 -- 117,000,915(+) C/T intron_variant
rs1000024647 -- 116,991,472(+) C/G intron_variant
rs1000027236 -- 116,947,451(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000028194 -- 117,030,935(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW8 Gene

Variant ID Type Subtype PubMed ID
dgv1562n100 CNV gain 25217958
esv2746432 CNV deletion 23290073
esv3549840 CNV deletion 23714750
esv3630861 CNV loss 21293372
nsv519118 CNV loss 19592680
nsv832524 CNV gain 17160897
nsv900 CNV insertion 18451855

Variation tolerance for FBXW8 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXW8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXW8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW8 Gene

Disorders for FBXW8 Gene

Additional Disease Information for FBXW8

No disorders were found for FBXW8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW8 Gene

Publications for FBXW8 Gene

  1. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 4 58
  2. The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. (PMID: 24362026) Wang H … Wang H (The Journal of biological chemistry 2014) 3 4 58
  3. The 3M complex maintains microtubule and genome integrity. (PMID: 24793695) Yan J … Xiong Y (Molecular cell 2014) 3 4 58
  4. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. (PMID: 21572988) Litterman N … Bonni A (PLoS biology 2011) 3 4 58
  5. The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. (PMID: 18498745) Xu X … Pan ZQ (Molecular cell 2008) 3 4 58

Products for FBXW8 Gene

Sources for FBXW8 Gene

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