FBXW7 Gene
protein-coding GIFtS: 63
GCID: GC04M153242
|
|
F-box and WD repeat domain containing 7, E3 ubiquitin protein...(Previous names: F-box and WD-40 domain protein 7 (archipelago homolog,...)
| |
Aliases
for FBXW7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase1 2 | | FLJ110711 | | FBW71 2 3 | | F-Box And WD Repeat Domain Containing 71 | | FBX301 2 3 | | FBW62 | | SEL-101 2 3 | | FBXO302 | | SEL101 2 3 | | Archipelago1 | | AGO1 2 5 | | F-Box Protein FBW72 | | CDC41 2 5 | | F-Box Protein SEL-102 | | FBXW61 2 | | F-Box/WD Repeat-Containing Protein 72 | | F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila)1 2 | | Homolog Of C Elegans Sel-102 | | F-Box Protein FBX302 3 | | Archipelago Homolog3 | | HAgo1 | | F-Box And WD-40 Domain-Containing Protein 73 | | HCdc41 | | |
Export aliases for FBXW7 gene to outside databasesPrevious GC identifers: GC04M154093 GC04M153631 GC04M153708 GC04M153820 GC04M153821 GC04M153600 GC04M153461 GC04M148968 |
Summaries
for FBXW7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXW7:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previouslyreferred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation.Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role inthe pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for thisgene. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and bindsto phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellulardomain (NICD), and probably PSEN1
Gene Wiki entry for FBXW7
|
Genomic Views
for FBXW7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXW7 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXW7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q31.3 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q31.23FBXW7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M153242: view genomic region
(about GC identifiers)
Start:
|
153,242,410 bp from pter |
End:
|
153,456,172 bp from pter |
Size:
|
213,763 bases |
Orientation:
|
minus strand |
|
Proteins
for FBXW7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0 (See
protein sequence)Recommended Name: F-box/WD repeat-containing protein 7 Size: 707 amino acids; 79663 Da
Subunit: Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E,NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with USP28, leadingto counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T antigen (via CPD region).Forms a trimeric complex with NOTCH1 and SGK1
Subcellular location: Isoform 1: Nucleus, nucleoplasm
Subcellular location: Isoform 2: Cytoplasm
Subcellular location: Isoform 4: Nucleus, nucleolus
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA91986.1; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for FBXW7:2OVP (3D)
2OVQ (3D)
2OVR (3D)
Secondary accessions: B7ZLP9 Q68DR0 Q96A16 Q96LE0 Q96RI2 Q9NUX6Alternative splicing: 4 isoforms: Q969H0-1 Q969H0-2 Q969H0-3 Q969H0-4 (Incomplete sequence)Explore the universe of human proteins at neXtProt for FBXW7: NX_Q969H0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969H0
FBXW7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001013433.1 NP_001243998.1 NP_060785.2 NP_361014.1
ENSEMBL proteins: ENSP00000281708 ENSP00000296555 ENSP00000263981 ENSP00000377528 Reactome Protein details: Q969H0
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
FBXW7 for ontologies About GeneDecksing
FBXW7 Antibody Products:
Assay Products for FBXW7: |
Protein
Domains /
Families
for FBXW7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXW7 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q969H0ProtoNet protein and cluster: Q969H0 UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0Similarity: Contains 1 F-box domainSimilarity: Contains 7 WD repeats |
Function
for FBXW7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and bindsto phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellulardomain (NICD), and probably PSEN1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW7 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FBXW7 (NM_018315) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
FBXW7 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for FBXW7:
Animal Models:
Mouse knock-outs for FBXW7: Fbxw7tm1Sje Fbxw7tm1Kin Fbxw7tm1.2Axbe Fbxw7tm1.1Kei
15/16 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Fbxw7) (see all 16):
FBXW7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FBXW7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Antigen processing: Ubiquitination & Proteasome degradation | | | 3 | Chaperonin-mediated protein folding | | | 4 | FBXW7 WD mutants do not bind NICD1 | | | 5 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 EMD Millipore Pathways for FBXW7 (see all 7)
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FBXW7
5/7  GeneGo (Thomson Reuters) Pathways for FBXW7 (see all 7)
3  BioSystems Pathways for FBXW7
5/25 
Reactome Pathways for FBXW7 (see all 25)
1 
Kegg Pathway (Kegg details for FBXW7):
FBXW7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXW7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/118 Interacting proteins for FBXW7 (Q969H01, 2, 3 ENSP000002817084) via UniProtKB, MINT, STRING, and/or I2D (see all 118)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CUL1 | Q136162, 3, ENSP000003268044 | MINT-8399620 MINT-49913 MINT-8399514 I2D:
score=9 STRING: ENSP00000326804 | | NFKB2 | Q006532, 3, ENSP000001894444 | MINT-48602 MINT-47892 I2D:
score=1 STRING: ENSP00000189444 | | MYC | P011061, 3, ENSP000003672074 | EBI-359574,EBI-1058440 I2D:
score=6 STRING: ENSP00000367207 | | ARL6IP1 | Q150412, 3, ENSP000003067884 | MINT-64199 I2D:
score=5 STRING: ENSP00000306788 | | LINGO1 | Q96FE52, 3, ENSP000003474514 | MINT-64690 I2D:
score=5 STRING: ENSP00000347451 |
About this table
Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table
FBXW7 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXW7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FBXW7 for compounds About GeneDecksing
 Browse Tocris compounds for FBXW7
1 Novoseek chemical compound relationship for FBXW7 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glycogen |
38.8 |
2 |
15150404 (2) |
Search CenterWatch for drugs/clinical trials and news about FBXW7
|
Transcripts
for FBXW7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXW7 gene (4 alternative transcripts): NM_001013415.1 NM_001257069.1 NM_018315.4 NM_033632.3 Unigene Clusters for FBXW7: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Hs.561245 [show with all ESTs], Hs.717081 [show with all ESTs]Unigene Representative Sequences: NM_033632, NM_0012570694 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281708(uc003ims.3 uc011cii.2 uc003imt.3 uc003imu.3 uc021xsx.1 uc021xsy.1 uc021xsz.1 uc021xta.1 uc021xtb.1 uc021xtc.1)
ENST00000296555(uc011cih.2 uc003imr.3) ENST00000263981(uc003imq.3)
ENST00000393956
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW7 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FBXW7 (NM_018315) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW7 |
Additional cDNA sequence: BC014503.1 HQ873864.1 HQ873865.1 HQ873866.1 HQ873867.1 HQ873868.1 HQ873869.1 HQ873870.1 7 DOTS entries: DT.95070871 DT.97858626 DT.443681 DT.212124 DT.100815994 DT.95070868 DT.121266504 24/139 AceView cDNA sequences (see all 139): AI991517 BM854069 AI656085 BU618580 AL705166 AF383178 AI350509 AF411972 BG232046 AK131383 AI452813 AI559196 AI269047 CA423513 BM930621 AI090532 BQ128200 AI457819 AW157489 CA867127 BX096920 CA425646 BQ673721 AA261922
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW7 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | - | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXW7
|
Expression
for FBXW7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXW7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FBXW7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXW7
SOURCE GeneReport for Unigene clusters: Hs.561245 Hs.717081
UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0Tissue specificity: Isoform 1 is widely expressed. Isoform 4 is expressed in brain
SABiosciences Expression via Pathway-Focused PCR Array including FBXW7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXW7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW7 |
Orthologs
for FBXW7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXW7 gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FBXW71 |
F-box and WD repeat domain containing 7 |
85.8(n)
94.73(a) |
|
422481 XM_420447.3 XP_420447.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FBXW76-- |
-- |
88(a)74(a) |
1 ↔ 1possible ortholog |
5(131720029-131763625) GL343952.1(8855-20641) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.328372 |
Xenopus laevis transcribed sequence with strong similarity more |
82.78(n) |
|
AW640941.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BI881652.12 |
-- |
79.84(n) |
|
BI881652.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ago3 |
cyclin catabolism ubiquitin-protein ligase |
74(a) |
|
3 64A12 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
sel-106 |
F-box/WD repeat-containing protein sel-10 |
44(a) |
1 ↔ 1 |
V(13818118-13823073) |
ENSEMBL Gene Tree for FBXW7 (if available)
TreeFam Gene Tree for FBXW7 (if available) |
Paralogs
for FBXW7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXW7 gene
- TRAF72 BTRC2 FBXW22 ZNF1062 FBXW112 WDR862
18 SIMAP similar genes for FBXW7 using alignment to 6 protein entries: FBXW7_HUMAN (see all proteins):PAAF1 PF20 WDR69 CDRT1 WDR5 EIF3I
WDR5B FBXW11 PAFAH1B1 WDR83 WDR86 BTRC
DKFZp781N011 GNB5 FBXW2 LOC349136 GNB2 WSB1
FBXW7 for paralogs About GeneDecksing
|
Genomic Variants
for FBXW7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FBXW7
1 CNV: 51274
Human Gene Mutation Database (HGMD): FBXW7
| 5/24 SABiosciences Cancer Mutation PCR Assays for FBXW7 (see all 24): |
| 5/10 SABiosciences Cancer Mutation PCR Arrays containing FBXW7 (see all 10): |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing FBXW7: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW7 |
|
Disorders
/ Diseases
for FBXW7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXW7 for disorders About GeneDecksing
OMIM gene information: 606278
OMIM disorders: --
20/35  diseases for FBXW7 (see all 35): About MalaCardscornelia de lange syndrome breast cancer non-hodgkin lymphoma hodgkin's lymphoma
acute lymphoblastic leukemia acute lymphocytic leukemia lymphoblastic leukemia lymphocytic leukemia
familial colorectal cancer endometrial cancer wilms tumor squamous cell carcinoma
leukemia thymoma colorectal cancer endometrial carcinoma
prostate cancer hermaphroditism noma acute leukemia
8 Novoseek disease relationships for FBXW7 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| t-all |
67.3 |
26 |
17575125 (4), 18485478 (3), 17646409 (2), 18185524 (1) |
| allelic loss |
50.5 |
2 |
14507635 (1), 17326833 (1) |
| tumors |
32.7 |
45 |
17326833 (7), 12183400 (3), 16131838 (3), 19420964 (2) (see all 14) |
| cancer |
31.4 |
22 |
16357515 (2), 15980150 (2), 17486057 (1), 19420964 (1) (see all 13) |
| endometrial cancer |
26.2 |
2 |
12183400 (1), 17088941 (1) |
| lymphoma |
16.6 |
2 |
15150404 (1), 15592418 (1) |
| glioma |
9.3 |
8 |
17326833 (5) |
| prostate cancer |
0 |
8 |
16357515 (5), 17274947 (1) |
Human Genome Epidemiology (HuGE) Navigator: FBXW7 (19 documents)
Export disorders for FBXW7 gene to outside databases
|
Publications
for FBXW7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXW7 gene, integrated from 9 sources (see all 182):
(articles sorted by number of sources associating them with FBXW7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T....Harper J.W. (1999)
- SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. (PubMed id 12354302)1, 2, 9 Li J.... Gurney M.E. (2002)
- The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4. (PubMed id 15611062)1, 2, 9 Welcker M. and Clurman B.E. (2005)
- Serum- and glucocorticoid-inducible kinase 1 (SGK1) c ontrols Notch1 signaling by downregulation of protein stability through Fbw7 ub iquitin ligase. (PubMed id 21147854)1, 2 Mo J.S....Park H.S. (2011)
- Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. (PubMed id 17873522)1, 2 Popov N....Eilers M. (2007)
- The ubiquitin-specific protease USP28 is required for MYC stability. (PubMed id 17558397)1, 2 Popov N....Eilers M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. (PubMed id 15103331)1, 2 Yada M....Nakayama K.I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines. (PubMed id 11565033)1, 2 Moberg K.H.... Hariharan I.K. (2001)
|
External Searches for FBXW7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXW7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXW7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXW7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FBXW7 gene:
Search GeneIP for patents involving FBXW7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXW7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FBXW7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXW7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW7 | | | OriGene Protein Over-expression Lysate for FBXW7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBXW7 | | OriGene 3'-UTR Clone for FBXW7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FBXW7 | | OriGene Custom Protein Services for FBXW7 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXW7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXW7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW7 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FBXW7 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FBXW7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW7 |
|  |  |  | | | | ThermoFisher Antibodies for FBXW7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW7 |
|
|
|
|
