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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXW7 Gene

protein-coding   GIFtS: 66
GCID: GC04M153242

F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein...

(Previous names: F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And WD Repeat Domain Containing 7, E3 Ubiquitin Protein
Ligase1 2
     F-Box And WD Repeat Domain Containing 71
F-Box And WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila)1 2     FBW62
FBW72 3     FBXO302
FBX302 3     FBXW62
SEL-102 3     archipelago2
SEL102 3     F-Box Protein FBW72
F-Box Protein FBX302 3     F-Box Protein SEL-102
hAgo2 3     F-Box/WD Repeat-Containing Protein 72
hCdc42 3     Homolog Of C Elegans Sel-102
AGO2 5     Archipelago Homolog3
CDC42 5     F-Box And WD-40 Domain-Containing Protein 73
Archipelago Homolog (Drosophila)1     

External Ids:    HGNC: 167121   Entrez Gene: 552942   Ensembl: ENSG000001096707   OMIM: 6062785   UniProtKB: Q969H03   

Export aliases for FBXW7 gene to outside databases

Previous GC identifers: GC04M154093 GC04M153631 GC04M153708 GC04M153820 GC04M153821 GC04M153600 GC04M153461 GC04M148968


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXW7 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this
protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for
ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines,
implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for FBXW7 Gene: 
FBXW7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with FBXW7 include glomuvenous malformation, and cornelia de lange syndrome, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Antigen processing: Ubiquitination & Proteasome degradation. GO annotations related to this gene include protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TRAF7.

UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch
intracellular domain (NICD), and probably PSEN1

Gene Wiki entry for FBXW7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXW7 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXW7 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXW7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.23

FBXW7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M153242:  view genomic region     (about GC identifiers)

Start:
153,242,410 bp from pter      End:
153,457,253 bp from pter
Size:
214,844 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 7  
Size: 707 amino acids; 79663 Da
Subunit: Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1,
cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with
USP28, leading to counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T
antigen (via CPD region). Forms a trimeric complex with NOTCH1 and SGK1
Subcellular location: Isoform 1: Nucleus, nucleoplasm
Subcellular location: Isoform 2: Cytoplasm
Subcellular location: Isoform 4: Nucleus, nucleolus
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA91986.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for FBXW7:
2OVP (3D)        2OVQ (3D)        2OVR (3D)    
Secondary accessions: B7ZLP9 Q68DR0 Q96A16 Q96LE0 Q96RI2 Q9NUX6
Alternative splicing: 4 isoforms:  Q969H0-1   Q969H0-2   Q969H0-3   Q969H0-4   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for FBXW7: NX_Q969H0

Explore proteomics data for FBXW7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969H0

  • FBXW7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXW7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001013433.1  NP_001243998.1  NP_060785.2  NP_361014.1  

    ENSEMBL proteins: 
     ENSP00000281708   ENSP00000296555   ENSP00000263981   ENSP00000474725   ENSP00000377528  
     ENSP00000474971   ENSP00000474751   ENSP00000474538  
    Reactome Protein details: Q969H0
    Human Recombinant Protein Products for FBXW7: 
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    OriGene Protein Over-expression Lysate for FBXW7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FBXW7
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    Novus Biologicals FBXW7 Protein
    Novus Biologicals FBXW7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXW7 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0019005SCF ubiquitin ligase complex IDA15103331

    FBXW7 for ontologies           About GeneDecksing



    FBXW7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FBXW7
    R&D Systems Antibodies for FBXW7 (FBXW7/Cdc4)
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    Novus Biologicals FBXW7 Antibodies
    Abcam antibodies for FBXW7
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    ThermoFisher Antibodies for FBXW7
    LSBio Antibodies in human, mouse, rat for FBXW7 

    Assay Products for FBXW7: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXW7 
    Cloud-Clone Corp. CLIAs for FBXW7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001810 F-box_dom_cyclin-like
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q969H0

    ProtoNet protein and cluster: Q969H0

    UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 WD repeats


    FBXW7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXW7_HUMAN, Q969H0
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
    and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch
    intracellular domain (NICD), and probably PSEN1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI15070733
         
    FBXW7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FBXW7:
     Increased cell death HMECs cel  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         15/16 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Fbxw7) (see all 16):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  normal  respiratory system  tumorigenesis 

    FBXW7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FBXW7: Fbxw7tm1Sje Fbxw7tm1Kin Fbxw7tm1.2Axbe Fbxw7tm1.1Kei

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXW7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXW7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXW7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXW7 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXW7:
    hsa-mir-128 (MIRT004757), hsa-mir-107 (MIRT004756), hsa-mir-197 (MIRT003827)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXW7
    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXW7 (see all 114):
    hsa-miR-194* hsa-miR-549 hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-4325 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXW7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXW7
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FBXW7

    Clone
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    OriGene clones in human, mouse for FBXW7 (see all 21)
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    GenScript: all cDNA clones in your preferred vector (see all 3): FBXW7 (NM_018315)
    Sino Biological Human cDNA Clone for FBXW7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW7
    Sirion Biotech Customized lentivirus for stable overexpression of FBXW7 
                         Customized lentivirus expression plasmids for stable overexpression of FBXW7 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXW7 About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH10.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74
    2Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    3Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    4Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation0.39
    Cell cycle ESR1 regulation of G1/S transition0.33
    Cell cycle Regulation of G1/S transition (part 1)0.39
    Immune response MIF-JAB1 signaling0.32
    5Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for FBXW7 (see all 7)
        Development Notch Signaling Pathway
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle ESR1 regulation of G1/S transition
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    1 R&D Systems Pathway for FBXW7
        Notch Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FBXW7
        Notch Signaling
    SREBP Proteolysis

    5/7 GeneGo (Thomson Reuters) Pathways for FBXW7 (see all 7)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Proteolysis Putative ubiquitin pathway
    Cell cycle Role of SCF complex in cell cycle regulation

    3 BioSystems Pathways for FBXW7
        Parkin-Ubiquitin Proteasomal System pathway
    Delta-Notch Signaling Pathway
    Notch signaling pathway


    5/22        Reactome Pathways for FBXW7 (see all 22)
        Chaperonin-mediated protein folding
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
    NOTCH1 Intracellular Domain Regulates Transcription
    FBXW7 Mutants and NOTCH1 in Cancer


    1         Kegg Pathway  (Kegg details for FBXW7):
        Ubiquitin mediated proteolysis


    FBXW7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXW7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/121 Interacting proteins for FBXW7 (Q969H01, 2, 3 ENSP000002817084) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136162, 3, ENSP000003268044MINT-8399620 MINT-49913 MINT-8399514 I2D: score=9 STRING: ENSP00000326804
    NFKB2Q006532, 3, ENSP000001894444MINT-48602 MINT-47892 I2D: score=1 STRING: ENSP00000189444
    MYCP011061, 3, ENSP000003672074EBI-359574,EBI-447544 I2D: score=6 STRING: ENSP00000367207
    ARL6IP1Q150412, 3, ENSP000003067884MINT-64199 I2D: score=5 STRING: ENSP00000306788
    LINGO1Q96FE52, 3, ENSP000003474514MINT-64690 I2D: score=5 STRING: ENSP00000347451
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001944vasculature development TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006974response to DNA damage stimulus IDA17873522
    GO:0007062sister chromatid cohesion IMP15917200

    FBXW7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FBXW7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXW7

    1 Novoseek inferred chemical compound relationship for FBXW7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 38.8 2 15150404 (2)

    Search CenterWatch for drugs/clinical trials and news about FBXW7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXW7 gene (4 alternative transcripts): 
    NM_001013415.1  NM_001257069.1  NM_018315.4  NM_033632.3  

    Unigene Clusters for FBXW7:

    F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
    Hs.561245  [show with all ESTs], Hs.717081  [show with all ESTs]
    Unigene Representative Sequences: NM_033632, NM_001257069
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281708(uc003ims.3 uc011cii.2 uc003imt.3 uc003imu.3 uc021xsx.1 uc021xsy.1 uc021xsz.1 uc021xta.1 uc021xtb.1 uc021xtc.1)
    ENST00000296555(uc011cih.2 uc003imr.3) ENST00000263981(uc003imq.3)
    ENST00000603548 ENST00000603821 ENST00000393956 ENST00000603841 ENST00000604316
    ENST00000604069 ENST00000604822 ENST00000604872 ENST00000605042 ENST00000604095

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    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXW7 (see all 114):
    hsa-miR-194* hsa-miR-549 hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-219-5p hsa-miR-4325 hsa-miR-3613-3p
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW7
    Sirion Biotech Customized lentivirus for stable overexpression of FBXW7 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW7

    Additional mRNA sequence: 

    BC014503.1 HQ873864.1 HQ873865.1 HQ873866.1 HQ873867.1 HQ873868.1 HQ873869.1 HQ873870.1 

    7 DOTS entries:

    DT.95070871  DT.97858626  DT.443681  DT.212124  DT.100815994  DT.95070868  DT.121266504 

    24/139 AceView cDNA sequences (see all 139):

    AF383178 BU618580 BF115330 AY033553 BG232046 CK905743 AL705166 AI080718 
    AI652797 AA909415 AI651119 AF411971 CA867047 NM_033632 CD518829 BM992797 
    AI797475 AK001933 AA251733 AI269047 AI452813 CA423513 BM930621 AI559196 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW7    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:              -     -                 -                             -                           
    SP2:        -     -     -                 -                             -                           
    SP3:                                      -                             -                           
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for FBXW7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXW7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FBXW7 Expression
    About this image


    See FBXW7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXW7

    SOURCE GeneReport for Unigene clusters: Hs.561245 Hs.717081

    UniProtKB/Swiss-Prot: FBXW7_HUMAN, Q969H0
    Tissue specificity: Isoform 1 is widely expressed. Isoform 4 is expressed in brain

        SABiosciences Expression via Pathway-Focused PCR Array including FBXW7: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXW7 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw71 , 5 F-box and WD-40 domain protein 71, 5 90.99(n)1
    96.46(a)1
      3 (37.70 cM)5
    507541  NM_001177773.11  NP_001171244.11 
     848152685 
    chicken
    (Gallus gallus)
    Aves FBXW71 F-box and WD repeat domain containing 7 85.8(n)
    94.73(a)
      422481  XM_420447.3  XP_420447.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXW76
    --
    Uncharacterized protein
    93(a)
    72(a)
    1 ↔ 1
    possible ortholog
    5(131720000-131768255)
    GL343952.1(8855-20641)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.328372 Xenopus laevis transcribed sequence with strong similarity more 82.78(n)    AW640941.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI881652.12   -- 79.84(n)    BI881652.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ago3 cyclin catabolism ubiquitin-protein
    ligase
    74(a)   3 64A12   --
    worm
    (Caenorhabditis elegans)
    Secernentea sel-106
    F-box/WD repeat-containing protein sel-10
    45(a)
    1 ↔ 1
    V(13818132-13823087)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC4(YFL009W)4 F-box protein required for G1/S and G2/M transition, more   --   6(116145-118484) 850539  NP_116585.1 


    ENSEMBL Gene Tree for FBXW7 (if available)
    TreeFam Gene Tree for FBXW7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXW7 gene
    TRAF72  BTRC2  FBXW22  FBXW112  WDR862  ZNF1062  
    18/19 SIMAP similar genes for FBXW7 using alignment to 6 protein entries:     FBXW7_HUMAN (see all proteins) (see all similar genes):
    PAAF1    PF20    DAW1    CDRT1    WDR5    PAFAH1B1
    EIF3I    WDR5B    WDR17    FBXW11    WDR83    WDR86
    BTRC    DKFZp781N011    GNB5    FBXW2    LOC349136    GNB2

    FBXW7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3303 SNPs in FBXW7 are shown (see all 3303)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358804
    A colorectal cancer sample4--see VAR_0358802 R H mis40--------
    VAR_0178164
    An ovarian cancer cell line4--see VAR_0178162 R L mis40--------
    VAR_0358814
    A colorectal cancer sample4--see VAR_0358812 S L mis40--------
    VAR_0178154
    A acute lymphoblastic leukemia cell line4--see VAR_0178152 R C mis40--------
    VAR_0330304
    A breast cancer sample4--see VAR_0330302 E K mis40--------
    rs1477934561,2
    C--149109203(+) AATGT-/TCTGTTA 2 -- int10--------
    rs339645611,2
    C--149109204(+) ATGTT-/CTGTTAT 2 -- int10--------
    rs361122871,2
    C--149132762(+) TATGG-/GAAAAGAG 2 -- cds10--------
    rs597707291,2
    C--149145554(+) AAAAA-/A/AA  
            
    CTCAT
    2 -- int10--------
    rs1874613651,2
    --153026670(+) GACAAA/GTTGCC 3 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for FBXW7 (153242410 - 153457253 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FBXW7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4553CNV Insertion18451855
    nsv523798CNV Loss19592680
    nsv881544CNV Loss21882294
    nsv516218CNV Loss19592680
    nsv830116CNV Gain17160897


    Human Gene Mutation Database (HGMD): FBXW7
    5/24 SABiosciences Cancer Mutation PCR Assays for FBXW7 (see all 24):
    Cosmic IdAA Change
    22932p.R465C
    27055p.V504I
    22979p.S582L
    22970p.R224*
    22964p.R367*
    5/10 SABiosciences Cancer Mutation PCR Arrays containing FBXW7 (see all 10):
    Endometrial Cancer
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    Gastric Cancer
    Liver Cancer
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing FBXW7:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing FBXW7
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXW7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606278    OMIM disorders: --

    20/38 diseases for FBXW7 (see all 38):    About MalaCards
    glomuvenous malformation    cornelia de lange syndrome    polyploidy    familial colorectal cancer
    acute lymphocytic leukemia    noma    thymoma    breast cancer
    wilms tumor    acute lymphoblastic leukemia    lymphoblastic leukemia    endometrial carcinoma
    acute leukemia    hodgkin's lymphoma    non-hodgkin lymphoma    colorectal cancer
    kaposi's sarcoma    osteosarcoma    esophageal squamous cell carcinoma    t-cell leukemia

    1 disease from the University of Copenhagen DISEASES database for FBXW7:
    Leukemia

    FBXW7 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for FBXW7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 67.3 26 17575125 (4), 18485478 (3), 17646409 (2), 18185524 (1)
    allelic loss 50.5 2 14507635 (1), 17326833 (1)
    tumors 32.7 45 17326833 (7), 12183400 (3), 16131838 (3), 19420964 (2) (see all 14)
    cancer 31.4 22 16357515 (2), 15980150 (2), 17486057 (1), 19420964 (1) (see all 13)
    endometrial cancer 26.2 2 12183400 (1), 17088941 (1)
    lymphoma 16.6 2 15150404 (1), 15592418 (1)
    glioma 9.3 8 17326833 (5)
    prostate cancer 0 8 16357515 (5), 17274947 (1)

    Genetic Association Database (GAD): FBXW7
    Human Genome Epidemiology (HuGE) Navigator: FBXW7 (19 documents)

    Export disorders for FBXW7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXW7 gene, integrated from 9 sources (see all 206):
    (articles sorted by number of sources associating them with FBXW7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T....Harper J.W. (1999)
    2. SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. (PubMed id 12354302)1, 2, 9 Li J.... Gurney M.E. (2002)
    3. The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4. (PubMed id 15611062)1, 2, 9 Welcker M. and Clurman B.E. (2005)
    4. Serum- and glucocorticoid-inducible kinase 1 (SGK1) c ontrols Notch1 signaling by downregulation of protein stability through Fbw7 ub iquitin ligase. (PubMed id 21147854)1, 2 Mo J.S....Park H.S. (2011)
    5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    6. Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL. (PubMed id 20683149)1, 4 Erbilgin Y....Ozbek U. (2010)
    7. NOTCH1 and/or FBXW7 mutations predict for initial goo d prednisone response but not for improved outcome in pediatric T-cell acute ly mphoblastic leukemia patients treated on DCOG or COALL protocols. (PubMed id 20861909)1, 4 Zuurbier L....Meijerink J.P. (2010)
    8. Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. (PubMed id 20332316)1, 4 Williams R.D....Pritchard-Jones K. (2010)
    9. Wilms tumor 1 (WT1) gene mutations in pediatric T-cel l malignancies. (PubMed id 19847202)1, 4 Renneville A....CavAc H. (2009)
    10. Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia. (PubMed id 19794083)1, 4 Baldus C.D....Hofmann W.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55294 HGNC: 16712 AceView: FBXW7 Ensembl:ENSG00000109670 euGenes: HUgn55294
    ECgene: FBXW7 Kegg: 55294 H-InvDB: FBXW7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXW7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FBXW7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXW7 gene:
    Search GeneIP for patents involving FBXW7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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