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FBXW5 Gene

protein-coding   GIFtS: 52
GCID: GC09M139834

F-Box And WD Repeat Domain Containing 5

(Previous name: F-box and WD-40 domain protein 5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And WD Repeat Domain Containing 51 2     Fbw52
F-Box And WD-40 Domain-Containing Protein 52 3     F-Box/WD Repeat-Containing Protein 52
FBW53 5     WD Repeat-Containing F-Box Protein FBW52
F-Box And WD-40 Domain Protein 51     

External Ids:    HGNC: 136131   Entrez Gene: 544612   Ensembl: ENSG000001590697   OMIM: 6090725   UniProtKB: Q969U63   

Export aliases for FBXW5 gene to outside databases

Previous GC identifers: GC09M131098 GC09M131524 GC09M133275 GC09M135192 GC09M137110 GC09M138954 GC09M109294


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXW5 Gene:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40
amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box
proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however,
they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. (provided by RefSeq,
Jul 2008)

GeneCards Summary for FBXW5 Gene:
FBXW5 (F-box and WD repeat domain containing 5) is a protein-coding gene. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6
Function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3
ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase
complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading
to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of
actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape
changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein
ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a
negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway

Gene Wiki entry for FBXW5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXW5 gene promoter:
         USF1   p53   AML1a   AP-1   AP-2gamma   HEN1   PPAR-gamma1   USF-1   STAT3   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FBXW5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXW5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

FBXW5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139834:  view genomic region     (about GC identifiers)

Start:
139,834,887 bp from pter      End:
139,839,173 bp from pter
Size:
4,287 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 5  
Size: 566 amino acids; 63922 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1,
RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B),
DDB1, FBXW5 and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6
Developmental stage: Degraded by the APC/C complex during G1 phase and reaccumulates at the G1/S phase transition
Sequence caution: Sequence=AAG17240.1; Type=Frameshift; Positions=Several; Sequence=AAG23772.1; Type=Frameshift;
Positions=Several; Sequence=AAH00850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI12741.1; Type=Erroneous gene model prediction; Sequence=CAI12744.1; Type=Erroneous gene model
prediction;
Secondary accessions: B2RDZ6 Q59ET5 Q5SPZ8 Q5SPZ9 Q5SQ00 Q5SQ02 Q5SQ03 Q5SQ04 Q8WY79 Q96GJ6
Q9BSU8 Q9H6A8 Q9HBQ6 Q9NSZ3
Alternative splicing: 2 isoforms:  Q969U6-1   Q969U6-2   

Explore the universe of human proteins at neXtProt for FBXW5: NX_Q969U6

Explore proteomics data for FBXW5 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS61
  • Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase1
  • Ubiquitination2 at Lys240, Lys299, Lys337
  • Modification sites at PhosphoSitePlus

  • See FBXW5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061871.1  
    ENSEMBL proteins: 
     ENSP00000313034   ENSP00000409102   ENSP00000404829   ENSP00000394011  
    Reactome Protein details: Q969U6

    FBXW5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FBXW5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR001810 F-box_dom
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q969U6

    ProtoNet protein and cluster: Q969U6

    UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6
    Domain: The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD
    repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes (Probable)
    Domain: The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal
    for degradation via the ubiquitin-proteasome pathway (By similarity)
    Similarity: Belongs to the FBXW5 family
    Similarity: Contains 1 F-box domain
    Similarity: Contains 3 WD repeats


    Find genes that share domains with FBXW5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXW5_HUMAN, Q969U6
    Function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3
    ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase
    complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading
    to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of
    actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape
    changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein
    ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a
    negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI15070733
    GO:0019901protein kinase binding IPI--
         
    Find genes that share ontologies with FBXW5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXW5:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW5
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FBXW5:
    hsa-miR-744* hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidFBXW5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FBXW5 (NM_018998)
    Sino Biological Human cDNA Clone for FBXW5
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBXW5_HUMAN, Q969U6: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0019005SCF ubiquitin ligase complex IDA--
    GO:0080008Cul4-RING ubiquitin ligase complex IDA18381890

    Find genes that share ontologies with FBXW5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXW5 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with FBXW5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FBXW5
        Association of TriC/CCT with target proteins during biosynthesis


    UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including FBXW5: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FBXW5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXW5 (Q969U61, 2, 3 ENSP000003130344) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2R2Q712K32, 3, ENSP000002632284MINT-8276263 I2D: score=2 STRING: ENSP00000263228
    CUL1Q136162, 3, ENSP000003268044MINT-49912 I2D: score=1 STRING: ENSP00000326804
    SKP1P632081, 3, ENSP000002314874EBI-741068,EBI-307486 I2D: score=3 STRING: ENSP00000231487
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66140 I2D: score=5 STRING: ENSP00000377582
    MDFIQ997502, 3, ENSP000002303214MINT-67271 I2D: score=5 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IDA18381890
    GO:0051298centrosome duplication IMP--

    Find genes that share ontologies with FBXW5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXW5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXW5 gene (3 alternative transcripts): 
    NM_018998.3  NM_178225.1  NM_178226.1  

    Unigene Cluster for FBXW5:

    F-box and WD repeat domain containing 5
    Hs.522507  [show with all ESTs]
    Unigene Representative Sequence: NM_018998
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487794(uc010nbx.3) ENST00000325285 ENST00000483559(uc004cjx.3 uc004cjy.3)
    ENST00000459905(uc004cjz.3) ENST00000433269 ENST00000480818 ENST00000491246
    ENST00000428398 ENST00000443788
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    hsa-miR-744* hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidFBXW5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXW5
      QuantiFast Probe-based Assays in human, mouse, rat FBXW5

    Additional mRNA sequence: 

    AB209726.1 AF217998.1 AF258569.1 AK026081.1 AK315738.1 BC000850.1 BC004541.2 BC009429.1 
    BC014130.1 BC014297.2 

    17 DOTS entries:

    DT.455308  DT.100650209  DT.100841693  DT.100650211  DT.92447605  DT.100874650  DT.97854711  DT.92447602 
    DT.100650214  DT.121200994  DT.95373095  DT.95373102  DT.100696621  DT.121201000  DT.92447607  DT.92447608 
    DT.97772989 

    Selected AceView cDNA sequences (see all 442):

    CA310398 BM752543 BX279943 BM752539 AW733151 BI829565 BQ668592 BQ923145 
    AI084525 BQ009831 BM552592 BE901406 BI825557 BM682570 BU621346 CD251981 
    BU180856 CR601073 BM987620 BI090509 AI933942 BI830264 BG425196 BM680447 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                      -                                       
    SP2:        -                                                                     
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for FBXW5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXW5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCACGCACC
    FBXW5 Expression
    About this image

    FBXW5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXW5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522507
        Pathway & Disease-focused RT2 Profiler PCR Array including FBXW5: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXW5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw51 , 5 F-box and WD-40 domain protein 51, 5 85.46(n)1
    90.25(a)1
      2 (17.31 cM)5
    308391  NM_013908.41  NP_038936.11 
     255007505 
    chicken
    (Gallus gallus)
    Aves FBXW51 F-box and WD repeat domain containing 5 75.03(n)
    78.11(a)
      417289  NM_001030694.1  NP_001025865.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXW56
    F-box and WD repeat domain containing 5
    61(a)
    1 ↔ 1
    GL343888.1(37488-43665)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65342 Xenopus laevis transcribed sequence with weak similarity more 79.16(n)    BI442107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283842 Danio rerio cDNA clone MGC63874 IMAGE6789527, complete more 76.34(n)    BC057409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fbw51 Fbw5 56.34(n)
    46.01(a)
      33854  NM_135145.1  NP_608989.1 


    ENSEMBL Gene Tree for FBXW5 (if available)
    TreeFam Gene Tree for FBXW5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXW5 (see all 250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111459361,2
    C,F,A,H--139834515(+) CTGCCG/AACTCT 1 -- ds50016Minor allele frequency- A:0.08NA 134
    rs1822628781,2
    --139834596(+) CGTGGC/TCTACT 1 -- ds50010--------
    rs1420518251,2
    C--139834716(+) GCACAG/TGACCT 1 -- ds50010--------
    rs625804061,2
    C--139834747(+) CAGCAG/ATGACT 1 -- ds50012Minor allele frequency- A:0.04NA 122
    rs727610871,2
    --139834817(+) GACCAC/TGAGGT 1 -- ds50010--------
    rs1513328801,2
    --139834836(+) CTGTGC/TCAGCA 1 -- ds50010--------
    rs607421601,2
    F--139834846(+) AGTGCC/TCACAG 1 -- ds50011Minor allele frequency- T:0.14WA 118
    rs1470910421,2
    --139835003(+) ACAGCC/TAGGAG 1 -- ut310--------
    rs1152709041,2
    C,F--139835033(+) GCCACC/TGTCCA 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1384423051,2
    C--139835057(+) CCAGCC/TGAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXW5 (139834887 - 139839173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FBXW5 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997310CNV Deletion20482838
    esv2422220CNV Deletion17116639
    nsv894483CNV Loss21882294
    dgv8416n71CNV Loss21882294
    nsv894503CNV Loss21882294
    dgv8423n71CNV Loss21882294
    nsv894469CNV Loss21882294
    nsv524322CNV Loss19592680
    nsv894502CNV Loss21882294
    dgv8415n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXW5
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXW5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609072    OMIM disorders: --


    Find genes that share disorders with FBXW5           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: FBXW5 (1 document)

    Export disorders for FBXW5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXW5 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with FBXW5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. (PubMed id 21725316)1, 2 Puklowski A....Malek N.P. (Nat. Cell Biol. 2011)
    2. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL- 1beta signaling pathway. (PubMed id 19232515)1, 2 Minoda Y.... Takaesu G. (Biochem. Biophys. Res. Commun. 2009)
    3. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. (PubMed id 18381890)1, 2 Hu J....Xiong Y. (Genes Dev. 2008)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth. (PubMed id 24082123)1 Kim T.Y....Der C.J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression. (PubMed id 23314863)1 Werner A....Melchior F. (Nat. Cell Biol. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54461 HGNC: 13613 AceView: FBXW5 Ensembl:ENSG00000159069 euGenes: HUgn54461
    ECgene: FBXW5 H-InvDB: FBXW5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXW5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXW5 gene:
    Search GeneIP for patents involving FBXW5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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