Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXW5 Gene

Aliases for FBXW5 Gene

  • F-Box And WD Repeat Domain Containing 5 2 3 5
  • F-Box And WD-40 Domain-Containing Protein 5 3 4
  • Fbw5 3 4
  • WD Repeat-Containing F-Box Protein FBW5 3
  • F-Box And WD-40 Domain Protein 5 2

External Ids for FBXW5 Gene

Previous GeneCards Identifiers for FBXW5 Gene

  • GC09M131098
  • GC09M131524
  • GC09M133275
  • GC09M135192
  • GC09M137110
  • GC09M138954
  • GC09M139834
  • GC09M109294

Summaries for FBXW5 Gene

Entrez Gene Summary for FBXW5 Gene

  • This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW5 Gene

FBXW5 (F-Box And WD Repeat Domain Containing 5) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for FBXW5 Gene

  • Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.

Gene Wiki entry for FBXW5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW5 Gene

Genomics for FBXW5 Gene

Regulatory Elements for FBXW5 Gene

Enhancers for FBXW5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXW5 on UCSC Golden Path with GeneCards custom track

Promoters for FBXW5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXW5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXW5 Gene

Chromosome:
9
Start:
136,940,433 bp from pter
End:
136,944,774 bp from pter
Size:
4,342 bases
Orientation:
Minus strand

Genomic View for FBXW5 Gene

Genes around FBXW5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW5 Gene

Proteins for FBXW5 Gene

  • Protein details for FBXW5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969U6-FBXW5_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 5
    Protein Accession:
    Q969U6
    Secondary Accessions:
    • B2RDZ6
    • Q59ET5
    • Q5SPZ8
    • Q5SPZ9
    • Q5SQ00
    • Q5SQ02
    • Q5SQ03
    • Q5SQ04
    • Q8WY79
    • Q96GJ6
    • Q9BSU8
    • Q9H6A8
    • Q9HBQ6
    • Q9NSZ3

    Protein attributes for FBXW5 Gene

    Size:
    566 amino acids
    Molecular mass:
    63922 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6. Interacts with TNFAIP8L1; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.
    SequenceCaution:
    • Sequence=AAG17240.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAG23772.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH00850.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12744.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW5 Gene

Proteomics data for FBXW5 Gene at MOPED

Post-translational modifications for FBXW5 Gene

  • Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6.
  • Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase.
  • Ubiquitination at Lys 240, Lys 299, and Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXW5 Gene

No data available for DME Specific Peptides for FBXW5 Gene

Domains & Families for FBXW5 Gene

Protein Domains for FBXW5 Gene

Suggested Antigen Peptide Sequences for FBXW5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969U6

UniProtKB/Swiss-Prot:

FBXW5_HUMAN :
  • The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.
  • Belongs to the FBXW5 family.
  • Contains 7 WD repeats.
Domain:
  • The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.
  • The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Contains 1 F-box domain.
Family:
  • Belongs to the FBXW5 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FBXW5: view

Function for FBXW5 Gene

Molecular function for FBXW5 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
genes like me logo Genes that share phenotypes with FBXW5: view

Animal Model Products

miRNA for FBXW5 Gene

miRTarBase miRNAs that target FBXW5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXW5 Gene

Localization for FBXW5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXW5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXW5 Gene COMPARTMENTS Subcellular localization image for FBXW5 gene
Compartment Confidence
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FBXW5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 18381890
genes like me logo Genes that share ontologies with FBXW5: view

Pathways & Interactions for FBXW5 Gene

genes like me logo Genes that share pathways with FBXW5: view

UniProtKB/Swiss-Prot Q969U6-FBXW5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXW5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA,IDA 21725316
genes like me logo Genes that share ontologies with FBXW5: view

No data available for SIGNOR curated interactions for FBXW5 Gene

Drugs & Compounds for FBXW5 Gene

No Compound Related Data Available

Transcripts for FBXW5 Gene

Unigene Clusters for FBXW5 Gene

F-box and WD repeat domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for FBXW5 Gene

GeneLoc Exon Structure for
FBXW5
ECgene alternative splicing isoforms for
FBXW5

Expression for FBXW5 Gene

mRNA expression in normal human tissues for FBXW5 Gene

Protein differential expression in normal tissues from HIPED for FBXW5 Gene

This gene is overexpressed in Lung (48.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXW5 Gene



SOURCE GeneReport for Unigene cluster for FBXW5 Gene Hs.522507

genes like me logo Genes that share expression patterns with FBXW5: view

Protein tissue co-expression partners for FBXW5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXW5 Gene

Orthologs for FBXW5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXW5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXW5 35
  • 88.77 (n)
  • 90.43 (a)
FBXW5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXW5 35
  • 86.77 (n)
  • 91.81 (a)
FBXW5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxw5 35
  • 85.46 (n)
  • 90.25 (a)
Fbxw5 16
Fbxw5 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXW5 35
  • 98.82 (n)
  • 99.05 (a)
FBXW5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxw5 35
  • 86.05 (n)
  • 90.43 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXW5 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXW5 35
  • 75.03 (n)
  • 78.11 (a)
FBXW5 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXW5 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6534 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28384 35
fbxw5 35
  • 69.91 (n)
  • 72.66 (a)
fbxw5 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010041 35
  • 57.79 (n)
  • 50.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fbw5 35
  • 56.34 (n)
  • 46.01 (a)
Fbw5 36
  • 37 (a)
OneToOne
Species with no ortholog for FBXW5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW5 Gene

ENSEMBL:
Gene Tree for FBXW5 (if available)
TreeFam:
Gene Tree for FBXW5 (if available)

Paralogs for FBXW5 Gene

No data available for Paralogs for FBXW5 Gene

Variants for FBXW5 Gene

Sequence variations from dbSNP and Humsavar for FBXW5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7850438 - 136,942,124(+) GCGCT(C/T)GGGTG nc-transcript-variant, reference, missense
rs1051014 -- 136,940,475(-) CACGC(A/C)CCACC nc-transcript-variant, utr-variant-3-prime
rs113070962 -- 136,942,053(+) ATCTG(A/G)TGTGG intron-variant, nc-transcript-variant, reference, synonymous-codon
rs113411466 -- 136,941,686(+) ATGCC(A/G/T)GCAGG splice-acceptor-variant
rs113874081 -- 136,940,412(+) CCCTG(C/T)AGACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FBXW5 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8408n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv818738 CNV Gain 17921354
dgv8419n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894500 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894503 CNV Loss 21882294
esv997310 CNV Deletion 20482838
dgv8424n71 CNV Loss 21882294
nsv482133 CNV Gain 20164927

Variation tolerance for FBXW5 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXW5 Gene

Disorders for FBXW5 Gene

Relevant External Links for FBXW5

Human Genome Epidemiology (HuGE) Navigator
FBXW5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXW5

No disorders were found for FBXW5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW5 Gene

Publications for FBXW5 Gene

  1. The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. (PMID: 21725316) Puklowski A. … Malek N.P. (Nat. Cell Biol. 2011) 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for FBXW5 Gene

Sources for FBXW5 Gene

Content