Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXW5 Gene

protein-coding   GIFtS: 52
GCID: GC09M139834

F-Box And WD Repeat Domain Containing 5

(Previous name: F-box and WD-40 domain protein 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And WD Repeat Domain Containing 51 2     F-Box/WD Repeat-Containing Protein 52
F-Box And WD-40 Domain-Containing Protein 52 3     WD Repeat-Containing F-Box Protein FBW52
F-Box And WD-40 Domain Protein 51     FBW53
Fbw52     

External Ids:    HGNC: 136131   Entrez Gene: 544612   Ensembl: ENSG000001590697   OMIM: 6090725   UniProtKB: Q969U63   

Export aliases for FBXW5 gene to outside databases

Previous GC identifers: GC09M131098 GC09M131524 GC09M133275 GC09M135192 GC09M137110 GC09M138954 GC09M109294


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXW5 Gene:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40
amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box
proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however,
they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. (provided by RefSeq,
Jul 2008)

GeneCards Summary for FBXW5 Gene: 
FBXW5 (F-box and WD repeat domain containing 5) is a protein-coding gene. Diseases associated with FBXW5 include tuberous sclerosis, and hepatitis b, and among its related super-pathways are Chaperonin-mediated protein folding and Post-translational protein modification. GO annotations related to this gene include protein kinase binding and catalytic activity.

UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6
Function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3
ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase
complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading
to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of
actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape
changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein
ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a
negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway

Gene Wiki entry for FBXW5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXW5 gene promoter:
         USF1   p53   AML1a   AP-1   AP-2gamma   HEN1   PPAR-gamma1   USF-1   STAT3   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FBXW5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

FBXW5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139834:  view genomic region     (about GC identifiers)

Start:
139,834,887 bp from pter      End:
139,839,173 bp from pter
Size:
4,287 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 5  
Size: 566 amino acids; 63922 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1,
RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B),
DDB1, FBXW5 and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6
Subcellular location: Cytoplasm
Developmental stage: Degraded by the APC/C complex during G1 phase and reaccumulates at the G1/S phase transition
Sequence caution: Sequence=AAG17240.1; Type=Frameshift; Positions=Several; Sequence=AAG23772.1; Type=Frameshift;
Positions=Several; Sequence=AAH00850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI12741.1; Type=Erroneous gene model prediction; Sequence=CAI12744.1; Type=Erroneous gene model
prediction;
Secondary accessions: B2RDZ6 Q59ET5 Q5SPZ8 Q5SPZ9 Q5SQ00 Q5SQ02 Q5SQ03 Q5SQ04 Q8WY79 Q96GJ6
Q9BSU8 Q9H6A8 Q9HBQ6 Q9NSZ3
Alternative splicing: 2 isoforms:  Q969U6-1   Q969U6-2   

Explore the universe of human proteins at neXtProt for FBXW5: NX_Q969U6

Explore proteomics data for FBXW5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6
  • UniProtKB: Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969U6

  • FBXW5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXW5 Protein Expression
    REFSEQ proteins: NP_061871.1  
    ENSEMBL proteins: 
     ENSP00000313034   ENSP00000409102   ENSP00000404829   ENSP00000394011  
    Reactome Protein details: Q969U6
    Human Recombinant Protein Products for FBXW5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FBXW5
    GenScript Custom Purified and Recombinant Proteins Services for FBXW5
    Novus Biologicals FBXW5 Proteins
    Novus Biologicals FBXW5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXW5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0019005SCF ubiquitin ligase complex IDA--
    GO:0080008Cul4-RING ubiquitin ligase complex IDA18381890

    FBXW5 for ontologies           About GeneDecksing



    FBXW5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FBXW5
    GenScript Custom Superior Antibodies Services for FBXW5
    Novus Biologicals FBXW5 Antibodies
    Search for Antibodies for FBXW5 at Abcam
    Cloud-Clone Corp. Antibodies for FBXW5 
    ThermoFisher Antibodies for FBXW5
    LSBio Antibodies in human, mouse, rat for FBXW5 

    Assay Products for FBXW5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXW5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXW5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXW5 
    Cloud-Clone Corp. CLIAs for FBXW5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR011041 Quinoprot_gluc/sorb_DH
     IPR001810 F-box_dom_cyclin-like
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q969U6

    ProtoNet protein and cluster: Q969U6

    UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6
    Domain: The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD
    repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes (Probable)
    Domain: The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal
    for degradation via the ubiquitin-proteasome pathway (By similarity)
    Similarity: Belongs to the FBXW5 family
    Similarity: Contains 1 F-box domain
    Similarity: Contains 3 WD repeats


    FBXW5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXW5_HUMAN, Q969U6
    Function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3
    ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase
    complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading
    to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of
    actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape
    changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein
    ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a
    negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI15070733
    GO:0019901protein kinase binding IPI--
         
    FBXW5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXW5:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXW5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXW5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXW5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXW5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXW5
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXW5:
    hsa-miR-744* hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidFBXW5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXW5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXW5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXW5
    Sirion Biotech Customized adenovirus for overexpression of FBXW5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FBXW5 (see all 7)
    OriGene ORF clones in mouse, rat for FBXW5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW5 (NM_018998)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW5
    Sirion Biotech Customized lentivirus for stable overexpression of FBXW5 
                         Customized lentivirus expression plasmids for stable overexpression of FBXW5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXW5
    Search LifeMap BioReagents cell lines for FBXW5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXW5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for FBXW5
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Metabolism of proteins
    Protein folding


    UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6
    Pathway: Protein modification; protein ubiquitination


    FBXW5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXW5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for FBXW5 (Q969U61, 2, 3 ENSP000003130344) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2R2Q712K32, 3, ENSP000002632284MINT-8276263 I2D: score=2 STRING: ENSP00000263228
    CUL1Q136162, 3, ENSP000003268044MINT-49912 I2D: score=1 STRING: ENSP00000326804
    SKP1P632081, 3, ENSP000002314874EBI-741068,EBI-307486 I2D: score=3 STRING: ENSP00000231487
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66140 I2D: score=5 STRING: ENSP00000377582
    MDFIQ997502, 3, ENSP000002303214MINT-67271 I2D: score=5 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA--
    GO:0043161proteasomal ubiquitin-dependent protein catabolic process IDA18381890
    GO:0051298centrosome duplication IMP--

    FBXW5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXW5

    Search CenterWatch for drugs/clinical trials and news about FBXW5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXW5 gene (3 alternative transcripts): 
    NM_018998.3  NM_178225.1  NM_178226.1  

    Unigene Cluster for FBXW5:

    F-box and WD repeat domain containing 5
    Hs.522507  [show with all ESTs]
    Unigene Representative Sequence: NM_018998
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487794(uc010nbx.3) ENST00000325285 ENST00000483559(uc004cjx.3 uc004cjy.3)
    ENST00000459905(uc004cjz.3) ENST00000433269 ENST00000480818 ENST00000491246
    ENST00000428398 ENST00000443788
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXW5
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXW5:
    hsa-miR-744* hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidFBXW5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXW5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXW5
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXW5 (see all 7)
    OriGene ORF clones in mouse, rat for FBXW5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW5 (NM_018998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW5
    Sirion Biotech Customized lentivirus for stable overexpression of FBXW5 
                         Customized lentivirus expression plasmids for stable overexpression of FBXW5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXW5
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXW5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXW5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW5

    Additional mRNA sequence: 

    AB209726.1 AF217998.1 AF258569.1 AK026081.1 AK315738.1 BC000850.1 BC004541.2 BC009429.1 
    BC014130.1 BC014297.2 

    17 DOTS entries:

    DT.455308  DT.100650209  DT.100841693  DT.100650211  DT.92447605  DT.100874650  DT.97854711  DT.92447602 
    DT.100650214  DT.121200994  DT.95373095  DT.95373102  DT.100696621  DT.121201000  DT.92447607  DT.92447608 
    DT.97772989 

    24/442 AceView cDNA sequences (see all 442):

    CR620078 BM726086 AL137631 BI160516 CA310398 AI933942 BM714513 BM764937 
    BQ772175 BI820489 BM772751 BC031100 BI830264 BQ772934 BI090509 BG425196 
    BM772728 BC035355 BC009429 BQ925700 BM846870 BC000850 CA313474 NM_018998 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                      -                                       
    SP2:        -                                                                     
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for FBXW5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXW5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCACGCACC
    FBXW5 Expression
    About this image


    See FBXW5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXW5

    SOURCE GeneReport for Unigene cluster: Hs.522507
        SABiosciences Expression via Pathway-Focused PCR Array including FBXW5: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXW5
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXW5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXW5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXW5 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw51 , 5 F-box and WD-40 domain protein 51, 5 85.46(n)1
    90.25(a)1
      2 (17.31 cM)5
    308391  NM_013908.41  NP_038936.11 
     255007505 
    chicken
    (Gallus gallus)
    Aves FBXW51 F-box and WD repeat domain containing 5 75.1(n)
    78.25(a)
      417289  NM_001030694.1  NP_001025865.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXW56
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343888.1(37488-43665)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65342 Xenopus laevis transcribed sequence with weak similarity more 79.16(n)    BI442107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283842 Danio rerio cDNA clone MGC63874 IMAGE6789527, complete more 76.34(n)    BC057409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fbw51 CG9144-PA 56.22(n)
    45.83(a)
      33854  NM_135145.1  NP_608989.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GID76
    Protein of unknown function, involved in proteasom...
    8(a)
    1 → many
    III(52645-54882)


    ENSEMBL Gene Tree for FBXW5 (if available)
    TreeFam Gene Tree for FBXW5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/250 SNPs in FBXW5 are shown (see all 250)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111459361,2
    C,F,A,H--139834515(+) CTGCCG/AACTCT 1 -- ds50016Minor allele frequency- A:0.08NA 134
    rs1822628781,2
    --139834596(+) CGTGGC/TCTACT 1 -- ds50010--------
    rs1420518251,2
    C--139834716(+) GCACAG/TGACCT 1 -- ds50010--------
    rs625804061,2
    C--139834747(+) CAGCAG/ATGACT 1 -- ds50012Minor allele frequency- A:0.04NA 122
    rs727610871,2
    --139834817(+) GACCAC/TGAGGT 1 -- ds50010--------
    rs1513328801,2
    --139834836(+) CTGTGC/TCAGCA 1 -- ds50010--------
    rs607421601,2
    F--139834846(+) AGTGCC/TCACAG 1 -- ds50011Minor allele frequency- T:0.14WA 118
    rs1470910421,2
    --139835003(+) ACAGCC/TAGGAG 1 -- ut310--------
    rs1152709041,2
    C,F--139835033(+) GCCACC/TGTCCA 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1384423051,2
    C--139835057(+) CCAGCC/TGAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXW5 (139834887 - 139839173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for FBXW5 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997310CNV Deletion20482838
    esv2422220CNV Deletion17116639
    nsv894483CNV Loss21882294
    dgv8416n71CNV Loss21882294
    nsv894503CNV Loss21882294
    dgv8423n71CNV Loss21882294
    nsv894469CNV Loss21882294
    nsv524322CNV Loss19592680
    nsv894502CNV Loss21882294
    dgv8415n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXW5
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXW5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609072    OMIM disorders: --

    5 diseases for FBXW5:    About MalaCards
    tuberous sclerosis    hepatitis b    multiple myeloma    myeloma
    hepatitis


    FBXW5 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: FBXW5 (1 document)

    Export disorders for FBXW5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXW5 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with FBXW5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. (PubMed id 21725316)1, 2 Puklowski A....Malek N.P. (2011)
    2. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. (PubMed id 19232515)1, 2 Minoda Y....Takaesu G. (2009)
    3. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. (PubMed id 18381890)1, 2 Hu J....Xiong Y. (2008)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. SCFFbxw5 mediates transient degradation of actin remod eller Eps8 to allow proper mitotic progression. (PubMed id 23314863)1 Werner A....Melchior F. (2013)
    9. Fbxw7a- and GSK3-mediated degradation of p100 is a pro -survival mechanism in multiple myeloma. (PubMed id 22388891)1 Busino L....Pagano M. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54461 HGNC: 13613 AceView: FBXW5 Ensembl:ENSG00000159069 euGenes: HUgn54461
    ECgene: FBXW5 H-InvDB: FBXW5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXW5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXW5 gene:
    Search GeneIP for patents involving FBXW5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXW5  
     OriGene qPCR primer pairs and template standards for FBXW5   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXW5  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXW5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXW5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXW5   OriGene Custom Protein Services for FBXW5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXW5
     QIAGEN SeqTarget long-range PCR primers for resequencing FBXW5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXW5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW5
     GenScript Custom Purified and Recombinant Proteins Services for FBXW5 GenScript cDNA clones with any tag delivered in your preferred vector for FBXW5
     GenScript Custom Assay Services for FBXW5 GenScript Custom Superior Antibodies Services for FBXW5
     GenScript Custom overexpressing Cell Line Services for FBXW5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FBXW5 promoter
     Search Chromatin IP Primers for FBXW5
     RT2 qPCR Primer Assay in human, mouse, rat FBXW5
     GNC Network for FBXW5
     SABiosciences PCR Arrays including human, mouse, rat FBXW5
     Search Tocris compounds for FBXW5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FBXW5 antibodies
     FBXW5 proteins
     FBXW5 lysates
     Search for Antibodies for FBXW5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FBXW5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FBXW5
     Antibodies for FBXW5
     ELISAs for FBXW5
     CLIAs for FBXW5
     Search LifeMap BioReagents cell lines for FBXW5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW5
     SwitchGear 3'UTR luciferase reporter plasmids for FBXW5
     Browse SwitchGear Promoter luciferase reporter plasmids for FBXW5
     ThermoFisher Antibodies for FBXW5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXW5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXW5
    Customized:
     lentivirus for stable overexpression of FBXW5
     lentivirus expression plasmids for stable overexpression of FBXW5
     adenovirus for overexpression of FBXW5
     LSBio Antibodies in human, mouse, rat for FBXW5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXW5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4