Aliases for FBXW5 Gene
Aliases for FBXW5 Gene
External Ids for FBXW5 Gene
- HGNC: 13613
- Entrez Gene: 54461
- Ensembl: ENSG00000159069
- OMIM: 609072
- UniProtKB: Q969U6
Previous GeneCards Identifiers for FBXW5 Gene
- GC09M131098
- GC09M131524
- GC09M133275
- GC09M135192
- GC09M137110
- GC09M138954
- GC09M139834
- GC09M109294
Summaries for FBXW5 Gene
-
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXW5 Gene
FBXW5 (F-Box And WD Repeat Domain Containing 5) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System. GO annotations related to this gene include protein kinase binding.
UniProtKB/Swiss-Prot for FBXW5 Gene
-
Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW5 Gene
Genomics for FBXW5 Gene
Regulatory Elements for FBXW5 Gene
Enhancers for FBXW5 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXW5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXW5 gene promoter:
Regulatory Element Products
Genomic Location for FBXW5 Gene
- Chromosome:
- 9
- Start:
- 136,940,433 bp from pter
- End:
- 136,944,774 bp from pter
- Size:
- 4,342 bases
- Orientation:
- Minus strand
Genomic View for FBXW5 Gene
Genes around FBXW5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.3 by Ensembl
- 9q34.3 by Entrez Gene
- 9q34.3 by HGNC
FBXW5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXW5 Gene
Proteins for FBXW5 Gene
-
Protein details for FBXW5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969U6-FBXW5_HUMAN
- Recommended name:
- F-box/WD repeat-containing protein 5
- Protein Accession:
- Q969U6
- B2RDZ6
- Q59ET5
- Q5SPZ8
- Q5SPZ9
- Q5SQ00
- Q5SQ02
- Q5SQ03
- Q5SQ04
- Q8WY79
- Q96GJ6
- Q9BSU8
- Q9H6A8
- Q9HBQ6
- Q9NSZ3
Protein attributes for FBXW5 Gene
- Size:
- 566 amino acids
- Molecular mass:
- 63922 Da
- Quaternary structure:
-
- Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6. Interacts with TNFAIP8L1; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.
- SequenceCaution:
-
- Sequence=AAG17240.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAG23772.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH00850.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12744.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for FBXW5 Gene
Post-translational modifications for FBXW5 Gene
- Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6.
- Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase.
- Ubiquitination at isoforms=2240, isoforms=2299, and isoforms=2337
- Modification sites at PhosphoSitePlus
Other Protein References for FBXW5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Protein Products
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- antibodies-online Proteins for FBXW5: See all 6
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-
Abcam proteins for FBXW5
Assay Products
- antibodies-online Kits for FBXW5: See all 15
No data available for DME Specific Peptides for FBXW5 Gene
Domains & Families for FBXW5 Gene
Gene Families for FBXW5 Gene
Protein Domains for FBXW5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXW5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q969U6UniProtKB/Swiss-Prot:
FBXW5_HUMAN :- The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.
- Belongs to the FBXW5 family.
- Domain:
-
- The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.
- The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
- Family:
-
- Belongs to the FBXW5 family.
Function for FBXW5 Gene
Molecular function for FBXW5 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 15070733 |
| GO:0019901 | protein kinase binding | IPI | 21725316 |
Phenotypes for FBXW5 Gene
- GenomeRNAi human phenotypes for FBXW5:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Decreased viability
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Increased G1 length, increased G2 length
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CRISPR Products
-
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-
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miRNA for FBXW5 Gene
- miRTarBase miRNAs that target FBXW5
miRNA Products
- Search ViGene Biosciences for FBXW5
Inhibitory RNA Products
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Cell Line Products
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXW5 Gene
Localization for FBXW5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXW5 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 21725316 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | 21725316 |
| GO:0080008 | Cul4-RING E3 ubiquitin ligase complex | IDA | 18381890 |
Pathways & Interactions for FBXW5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Chaperonin-mediated protein folding |
.94
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | Metabolism of proteins | ||
| 5 | Toll-like Receptor Signaling Pathway | ||
Pathways by source for FBXW5 Gene
1 BioSystems pathway for FBXW5 Gene
UniProtKB/Swiss-Prot Q969U6-FBXW5_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXW5 Gene
Selected Interacting proteins:
ENSP00000313034
Q969U6-FBXW5_HUMAN
for FBXW5 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0007088 | regulation of mitotic nuclear division | IEA | -- |
| GO:0010824 | regulation of centrosome duplication | IMP | 21725316 |
| GO:0016567 | protein ubiquitination | IDA | 18381890 |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA | 21725316 |
No data available for SIGNOR curated interactions for FBXW5 Gene
Transcripts for FBXW5 Gene
mRNA/cDNA for FBXW5 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (442) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXW5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXW5
-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: |
Expression for FBXW5 Gene
This gene is overexpressed in Lung (48.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXW5 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXW5 Gene:
FBXW5SOURCE GeneReport for Unigene cluster for FBXW5 Gene:
Hs.522507Evidence on tissue expression from TISSUES for FBXW5 Gene
- Nervous system(4.7)
- Intestine(4.3)
- Skin(4.3)
- Liver(2.7)
- Lung(2.7)
- Muscle(2.6)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXW5
-
OriGene qPCR primer pairs for FBXW5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW5 Gene
Orthologs for FBXW5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXW5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXW5 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXW5 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxw5 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxw5 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXW5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXW5 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXW5 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6534 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxw5 34 35 |
|
||
| Dr.28384 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010041 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Fbw5 34 35 |
|
- Species where no ortholog for FBXW5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXW5 Gene
No data available for Paralogs for FBXW5 Gene
Variants for FBXW5 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000019177 | -- | 136,941,658(+) | GGTCA(G/T)CTGGT | nc-transcript-variant, reference, missense | |
| rs1000096153 | -- | 136,944,601(+) | CGGCC(A/G)CCTCC | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000297928 | -- | 136,940,594(+) | GCCCC(A/G)CAGGA | nc-transcript-variant, utr-variant-3-prime | |
| rs1000391706 | -- | 136,940,491(+) | GCAAC(A/C/G)CACTC | nc-transcript-variant, utr-variant-3-prime | |
| rs1000862310 | -- | 136,943,052(+) | GCCAC(C/T)AGGGA | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.46;
54.95% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXW5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXW5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW5 Gene
Disorders for FBXW5 Gene
Relevant External Links for FBXW5
No disorders were found for FBXW5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW5 Gene
Publications for FBXW5 Gene
- The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. (PMID: 21725316) Puklowski A. … Malek N.P. (Nat. Cell Biol. 2011) 3 4 64
- An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL- 1beta signaling pathway. (PMID: 19232515) Minoda Y. … Takaesu G. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
- WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. (PMID: 18381890) Hu J. … Xiong Y. (Genes Dev. 2008) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
Products for FBXW5 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXW5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
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