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Aliases for FBXW2 Gene

Aliases for FBXW2 Gene

  • F-Box And WD Repeat Domain Containing 2 2 3
  • Fwd2 3 4 6
  • FBW2 3 4 6
  • F-Box And WD-40 Domain-Containing Protein 2 3 4
  • F-Box And WD-40 Domain Protein 2 2 3
  • F-Box/WD Repeat-Containing Protein 2 3
  • Protein MD6 4
  • Md6 3

External Ids for FBXW2 Gene

Summaries for FBXW2 Gene

Entrez Gene Summary for FBXW2 Gene

  • F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW2 Gene

FBXW2 (F-Box And WD Repeat Domain Containing 2) is a Protein Coding gene. Diseases associated with FBXW2 include foodborne botulism and infant botulism. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ZNF106.

UniProtKB/Swiss-Prot for FBXW2 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

Gene Wiki entry for FBXW2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW2 Gene

Genomics for FBXW2 Gene

Genomic Location for FBXW2 Gene

Start:
120,751,978 bp from pter
End:
120,793,462 bp from pter
Size:
41,485 bases
Orientation:
Minus strand

Genomic View for FBXW2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW2 Gene

Regulatory Elements for FBXW2 Gene

Proteins for FBXW2 Gene

  • Protein details for FBXW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT8-FBXW2_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 2
    Protein Accession:
    Q9UKT8
    Secondary Accessions:
    • B3KRL8
    • Q4VXH2
    • Q7Z4V6
    • Q8WV51
    • Q9HA09
    • Q9UKA3

    Protein attributes for FBXW2 Gene

    Size:
    454 amino acids
    Molecular mass:
    51512 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAF04465.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAF13226.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97276.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97280.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW2 Gene

Proteomics data for FBXW2 Gene at MOPED

Post-translational modifications for FBXW2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXW2 Gene

Domains for FBXW2 Gene

Gene Families for FBXW2 Gene

HGNC:
  • WDR :WD repeat domain containing
  • FBXW :F-boxes / WD-40 domains

UniProtKB/Swiss-Prot:

FBXW2_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q9UKT8
Similarity:
  • Contains 7 WD repeats.:
    • Q9UKT8
genes like me logo Genes that share domains with FBXW2: view

Function for FBXW2 Gene

Molecular function for FBXW2 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

Gene Ontology (GO) - Molecular Function for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding IPI 11238952
genes like me logo Genes that share ontologies with FBXW2: view

Phenotypes for FBXW2 Gene

genes like me logo Genes that share phenotypes with FBXW2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXW2 Gene

Localization for FBXW2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXW2 Gene COMPARTMENTS Subcellular localization image for FBXW2 gene
Compartment Confidence
cytosol 2
peroxisome 2
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FBXW2: view

Pathways for FBXW2 Gene

genes like me logo Genes that share pathways with FBXW2: view

Interacting Proteins for FBXW2 Gene

Gene Ontology (GO) - Biological Process for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10531035
GO:0006508 proteolysis TAS 10531035
GO:0016567 protein ubiquitination TAS 10531035
genes like me logo Genes that share ontologies with FBXW2: view

Transcripts for FBXW2 Gene

Unigene Clusters for FBXW2 Gene

F-box and WD repeat domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10:
SP11: -
SP12:

Relevant External Links for FBXW2 Gene

GeneLoc Exon Structure for
FBXW2
ECgene alternative splicing isoforms for
FBXW2

Expression for FBXW2 Gene

mRNA expression in normal human tissues for FBXW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FBXW2 Gene

SOURCE GeneReport for Unigene cluster for FBXW2 Gene Hs.494985

genes like me logo Genes that share expressions with FBXW2: view

Orthologs for FBXW2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW2 36
  • 99.71 (n)
  • 100 (a)
FBXW2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXW2 36
  • 95.15 (n)
  • 99.56 (a)
FBXW2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXW2 36
  • 96.55 (n)
  • 100 (a)
FBXW2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxw2 36
  • 95.81 (n)
  • 98.68 (a)
Fbxw2 16
Fbxw2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXW2 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 9 (a)
OneToMany
-- 37
  • 92 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxw2 36
  • 95.23 (n)
  • 98.68 (a)
chicken
(Gallus gallus)
Aves FBXW2 36
  • 84.65 (n)
  • 93.83 (a)
FBXW2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXW2 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fbxw2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw2 36
  • 78.34 (n)
  • 88.77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2865 36
zebrafish
(Danio rerio)
Actinopterygii Dr.7935 36
fbxw2 36
  • 71.81 (n)
  • 79.52 (a)
fbxw2 37
  • 80 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET30 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7775 37
  • 19 (a)
ManyToMany
Species with no ortholog for FBXW2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW2 Gene

ENSEMBL:
Gene Tree for FBXW2 (if available)
TreeFam:
Gene Tree for FBXW2 (if available)

Paralogs for FBXW2 Gene

Paralogs for FBXW2 Gene

Selected SIMAP similar genes for FBXW2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FBXW2 Gene

genes like me logo Genes that share paralogs with FBXW2: view

Variants for FBXW2 Gene

Sequence variations from dbSNP and Humsavar for FBXW2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs382400 -- 120,791,402(-) agtgg(C/G)tgaat intron-variant
rs384995 -- 120,785,938(-) gggtt(A/C/T)gagtc intron-variant
rs730804 -- 120,761,096(+) TCCAC(C/T)GGAGG utr-variant-3-prime
rs1804824 -- 120,760,167(-) TTTAG(G/T)TCCGT utr-variant-3-prime
rs2031973 -- 120,775,978(-) TGTAC(C/T)TACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW2 Gene

Variant ID Type Subtype PubMed ID
nsv7434 OTHER Inversion 18451855
nsv526071 CNV Loss 19592680
nsv893809 CNV Gain 21882294
nsv517321 CNV Loss 19592680

Relevant External Links for FBXW2 Gene

HapMap Linkage Disequilibrium report
FBXW2

Disorders for FBXW2 Gene

genes like me logo Genes that share disorders with FBXW2: view

No data available for UniProtKB/Swiss-Prot for FBXW2 Gene

Publications for FBXW2 Gene

  1. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 2 3 23
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  3. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 3 4
  4. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PMID: 18703417) Chiang M.H. … Chen H. (Biol. Reprod. 2008) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FBXW2 Gene

Sources for FBXW2 Gene

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