Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXW2 Gene

protein-coding   GIFtS: 51
GCID: GC09M123514

F-Box And WD Repeat Domain Containing 2

(Previous name: F-box and WD-40 domain protein 2)
  See FBXW2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box And WD Repeat Domain Containing 21 2     Fwd22
FBW22 3 5     Md62
F-Box And WD-40 Domain Protein 21 2     F-Box/WD Repeat-Containing Protein 22
F-Box And WD-40 Domain-Containing Protein 22 3     Protein MD63
FWD23 5     

External Ids:    HGNC: 136081   Entrez Gene: 261902   Ensembl: ENSG000001194027   OMIM: 6090715   UniProtKB: Q9UKT83   

Export aliases for FBXW2 gene to outside databases

Previous GC identifers: GC09M114631 GC09M115160 GC09M116980 GC09M118902 GC09M120606 GC09M122566 GC09M093137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXW2 Gene:
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid
motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of
cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases,
called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the
different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of
either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting
domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40
repeats. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXW2 Gene:
FBXW2 (F-box and WD repeat domain containing 2) is a protein-coding gene. Diseases associated with FBXW2 include foodborne botulism, and infant botulism. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXW7.

UniProtKB/Swiss-Prot: FBXW2_HUMAN, Q9UKT8
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

Gene Wiki entry for FBXW2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXW2 gene promoter:
         Max1   Sox5   RelA   AP-2gamma   NF-kappaB   SRY   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXW2 promoter sequence
   Search Chromatin IP Primers for FBXW2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXW2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34

FBXW2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M123514:  view genomic region     (about GC identifiers)

Start:
123,514,256 bp from pter      End:
123,555,740 bp from pter
Size:
41,485 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBXW2_HUMAN, Q9UKT8 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 2  
Size: 454 amino acids; 51512 Da
Subunit: Directly interacts with SKP1 and CUL1
Sequence caution: Sequence=AAF04465.1; Type=Frameshift; Positions=420; Sequence=AAF13226.1; Type=Frameshift;
Positions=420; Sequence=AAP97276.1; Type=Frameshift; Positions=420; Sequence=AAP97280.1; Type=Frameshift;
Positions=420;
Secondary accessions: B3KRL8 Q4VXH2 Q7Z4V6 Q8WV51 Q9HA09 Q9UKA3
Alternative splicing: 2 isoforms:  Q9UKT8-1   Q9UKT8-2   

Explore the universe of human proteins at neXtProt for FBXW2: NX_Q9UKT8

Explore proteomics data for FBXW2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXW2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036296.2  
    ENSEMBL proteins: 
     ENSP00000476369   ENSP00000398662   ENSP00000341161  
    Reactome Protein details: Q9UKT8

    FBXW2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FBXW2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FBXW2
    GenScript Custom Purified and Recombinant Proteins Services for FBXW2
    Novus Biologicals FBXW2 Protein
    Novus Biologicals FBXW2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXW2

     
    Search eBioscience for Proteins for FBXW2 

     
    antibodies-online proteins for FBXW2 (5 products) 

     
    antibodies-online peptides for FBXW2

    FBXW2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FBXW2
    OriGene Custom Antibody Services for FBXW2
    Novus Biologicals FBXW2 Antibodies
    Search for Antibodies for FBXW2 at Abcam
    Cloud-Clone Corp. Antibodies for FBXW2
    ThermoFisher Antibody for FBXW2
    LSBio Antibodies in human, mouse, rat for FBXW2
    antibodies-online antibodies for FBXW2 (26 products) 

    FBXW2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXW2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXW2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXW2
    Cloud-Clone Corp. CLIAs for FBXW2
    Search eBioscience for ELISAs for FBXW2 
    antibodies-online kits for FBXW2 (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001810 F-box_dom
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKT8

    ProtoNet protein and cluster: Q9UKT8

    UniProtKB/Swiss-Prot: FBXW2_HUMAN, Q9UKT8
    Similarity: Contains 1 F-box domain
    Similarity: Contains 4 WD repeats


    Find genes that share domains with FBXW2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXW2_HUMAN, Q9UKT8
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding IPI11238952
         
    Find genes that share ontologies with FBXW2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FBXW2:
     Decreased POU5F1-GFP protein e  Decreased influenza A/WSN/33 r  Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXW2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXW2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXW2

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXW2:
    hsa-mir-106b-5p (MIRT044308), hsa-mir-484 (MIRT041688), hsa-mir-192-5p (MIRT026356), hsa-mir-222-3p (MIRT046735), hsa-let-7a-5p (MIRT052421), hsa-mir-215-5p (MIRT024395), hsa-let-7b-5p (MIRT052115)

    Block miRNA regulation of human, mouse, rat FBXW2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXW2 (see all 72):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-146a hsa-miR-218-1* hsa-miR-200a hsa-miR-219-5p hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXW2
    Predesigned siRNA for gene silencing in human, mouse, rat FBXW2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXW2

    Clone
    Products:
         
    OriGene clones in human, mouse for FBXW2 (see all 7)
    OriGene ORF clones in mouse, rat for FBXW2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW2 (NM_012164)
    Sino Biological Human cDNA Clone for FBXW2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXW2
    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXW2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    peroxisome2
    endoplasmic reticulum1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----

    Find genes that share ontologies with FBXW2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FBXW2 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with FBXW2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for FBXW2
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency


    1 Reactome Pathway for FBXW2
        Association of TriC/CCT with target proteins during biosynthesis


        Pathway & Disease-focused RT2 Profiler PCR Array including FBXW2: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FBXW2

    Selected Interacting proteins for FBXW2 (Q9UKT81, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136162, 3MINT-8399481 MINT-49910 I2D: score=4 
    SKP1P632081, 3EBI-914727,EBI-307486 I2D: score=5 
    GCM1Q9NP623I2D: score=2 
    CDC34P494273I2D: score=1 
    EP300Q094723I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10531035
    GO:0006508proteolysis TAS10531035
    GO:0016567protein ubiquitination TAS10531035

    Find genes that share ontologies with FBXW2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXW2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FBXW2 gene: 
    NM_012164.3  

    Unigene Cluster for FBXW2:

    F-box and WD repeat domain containing 2
    Hs.494985  [show with all ESTs]
    Unigene Representative Sequence: NM_012164
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493559 ENST00000608872 ENST00000453291 ENST00000474117 ENST00000476481
    ENST00000340778
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXW2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXW2 (see all 72):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-146a hsa-miR-218-1* hsa-miR-200a hsa-miR-219-5p hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXW2
    Predesigned siRNA for gene silencing in human, mouse, rat FBXW2
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXW2 (see all 7)
    OriGene ORF clones in mouse, rat for FBXW2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW2 (NM_012164)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXW2
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXW2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXW2
      QuantiTect SYBR Green Assays in human, mouse, rat FBXW2
      QuantiFast Probe-based Assays in human, mouse, rat FBXW2

    Additional mRNA sequence: 

    AF129531.1 AF145024.1 AF176698.1 AF193594.1 AK022484.1 AK025767.1 AK054580.1 AK095377.1 
    AK300066.1 AK314385.1 BC000239.1 BC018738.1 BC024204.2 BC110334.1 BX537625.1 EF565099.1 
    U29107.1 

    14 DOTS entries:

    DT.100797148  DT.91712155  DT.102827326  DT.75100936  DT.100797152  DT.70103904  DT.75175588  DT.91712162 
    DT.95222880  DT.121143338  DT.121143331  DT.86798039  DT.121143309  DT.91947049 

    Selected AceView cDNA sequences (see all 315):

    BU689420 AA243378 AI090582 AI378307 AA297852 BM563833 BM712689 Z41147 
    BX092321 AA296704 BX091858 CA313547 AA436346 BC000239 BP336982 AI581129 
    AI954324 CB959510 CD624290 AA631150 BM725470 CA424895 CD107690 AI076115 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXW2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                          -           -                                         -                                         -                           
    SP2:                          -           -                                         -                                         -                           
    SP3:                                      -                                         -     -     -     -                       -                           
    SP4:                          -           -     -                                   -                                                                     
    SP5:                                      -     -                                   -                                                                     


    ECgene alternative splicing isoforms for FBXW2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FBXW2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FBXW2 Expression
    About this image


    FBXW2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Limb (Muscoskeletal System)
             Limb Bud
    FBXW2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXW2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494985
        Pathway & Disease-focused RT2 Profiler PCR Array including FBXW2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXW2
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXW2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXW2
    QuantiTect SYBR Green Assays in human, mouse, rat FBXW2
    QuantiFast Probe-based Assays in human, mouse, rat FBXW2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXW2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw21 , 5 F-box and WD-40 domain protein 21, 5 95.81(n)1
    98.68(a)1
      2 (22.96 cM)5
    300501  NM_001164768.11  NP_001158240.11 
     348045145 
    chicken
    (Gallus gallus)
    Aves FBXW21 F-box and WD repeat domain containing 2 84.65(n)
    93.83(a)
      417088  NM_001007842.1  NP_001007843.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXW26
    F-box and WD repeat domain containing 2
    92(a)
    1 ↔ 1
    GL343502.1(600888-609229)
    African clawed frog
    (Xenopus laevis)
    Amphibia fbxw2-prov2 F-box and WD-40 domain protein 2 79.97(n)    BC043833.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.79352 Transcribed sequence with moderate similarity to protein more 75.14(n)    57064010 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MET306
    F-box protein containing five copies of the WD40 m...
    18(a)
    1 → many
    IX(268651-270573) YIL046W


    ENSEMBL Gene Tree for FBXW2 (if available)
    TreeFam Gene Tree for FBXW2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FBXW2 gene
    FBXW72  TRAF72  BTRC2  FBXW112  WDR862  ZNF1062  
    3 SIMAP similar genes for FBXW2 using alignment to 3 protein entries:     FBXW2_HUMAN (see all proteins):
    POC1B    DAW1    FBXW7

    Find genes that share paralogs with FBXW2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FBXW2
    PGOHUM00000235477


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FBXW2 (see all 655)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415526711,2
    --123519087(+) TTAAAC/TAGTAT 1 -- ds50010--------
    rs109850251,2
    C,F,A,H--123519172(+) AACCAG/ATAATA 1 -- ds500112Minor allele frequency- A:0.08NS EA NA CSA WA 668
    rs1507321851,2
    C--123519179(+) AATATA/GTAAAC 1 -- ds50010--------
    rs1819233821,2
    --123519292(+) TAGATA/TAGTGA 1 -- ut310--------
    rs1861508081,2
    --123519326(+) ATCTCA/GACCAA 1 -- ut310--------
    rs1499150681,2
    C--123519335(+) AATGAC/TTTCAC 1 -- ut310--------
    rs2013540301,2
    C--123519447(+) ATAAAA/TATGTT 1 -- ut310--------
    rs665194591,2
    C--123519448(+) AAAAA-/AT/TA 
            
    TGTTG
    2 -- ut310--------
    rs1998624801,2
    C--123519450(-) GACAAC/TATTTT 1 -- ut310--------
    rs1449986931,2
    C--123519726(+) AGTATC/TTTCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXW2 (123514256 - 123555740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FBXW2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517321CNV Loss19592680
    nsv526071CNV Loss19592680
    nsv893809CNV Gain21882294
    nsv7434OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXW2
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXW2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609071    OMIM disorders: --

    9 diseases for FBXW2:    
    About MalaCards
    foodborne botulism    infant botulism    intestinal botulism    vestibular neuronitis
    neuronitis    wound botulism    botulism    benign paroxysmal positional nystagmus
    egg allergy

    7 diseases from the University of Copenhagen DISEASES database for FBXW2:
    Intestinal botulism     Wound botulism     Egg allergy     Infant botulism
    Foodborne botulism     Vestibular neuronitis     Benign paroxysmal positional nystagmus

    Find genes that share disorders with FBXW2           About GenesLikeMe


    Export disorders for FBXW2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FBXW2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with FBXW2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PubMed id 10828603)1, 3, 9 Chiaur D.S....Pagano M. (Cytogenet. Cell Genet. 2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    5. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PubMed id 18703417)1, 9 Chiang M.H.... Chen H. (Biol. Reprod. 2008)
    6. RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion. (PubMed id 23651062)1 Wang C.C....Chen H. (Biochem. J. 2013)
    7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    8. Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing I^TrCP. (PubMed id 22975506)1 Sasajima H....Yokosawa H. (amp 2012)
    9. Fbxw7I+- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. (PubMed id 22388891)1 Busino L....Pagano M. (Nat. Cell Biol. 2012)
    10. Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity. (PubMed id 21946088)1 Ponyeam W. and Hagen T. (Cell. Signal. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26190 HGNC: 13608 AceView: FBXW2 Ensembl:ENSG00000119402 euGenes: HUgn26190
    ECgene: FBXW2 H-InvDB: FBXW2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FBXW2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FBXW2 gene:
    Search GeneIP for patents involving FBXW2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FBXW2   OriGene RNAi products in human, mouse, rat for FBXW2  
     OriGene qPCR primer pairs and template standards for FBXW2   OriGene Protein Over-expression Lysate for FBXW2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXW2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXW2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXW2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXW2   OriGene Custom Protein Services for FBXW2  

     
     
     Block miRNA regulation of human, mouse, rat FBXW2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXW2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXW2 Predesigned siRNA for gene silencing in human, mouse, rat FBXW2
     QuantiFast Probe-based Assays in human, mouse, rat FBXW2 QuantiTect SYBR Green Assays in human, mouse, rat FBXW2
     PCR Arrays including human, mouse, rat FBXW2 Search Chromatin IP Primers for FBXW2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXW2  GeneGlobe Interaction Network for FBXW2
     Regulatory tfbs in FBXW2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FBXW2 GenScript cDNA clones with any tag delivered in your preferred vector for FBXW2
     GenScript Custom Assay Services for FBXW2 GenScript Custom overexpressing Cell Line Services for FBXW2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FBXW2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FBXW2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FBXW2 antibodies
     FBXW2 proteins
     FBXW2 lysates
     Search for Antibodies for FBXW2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FBXW2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FBXW2
     Antibodies for FBXW2
     ELISAs for FBXW2
     CLIAs for FBXW2



     Browse ESI BIO Cell Lines and PureStem Progenitors for FBXW2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FBXW2
     SwitchGear Promoter luciferase reporter plasmids for FBXW2
     ThermoFisher Antibody for FBXW2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXW2
     LSBio Antibodies in human, mouse, rat for FBXW2
     Browse compounds at ApexBio
     Search Addgene for plasmids for FBXW2
      Search eBioscience for proteins for FBXW2
      Search eBioscience for elisas for FBXW2
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for FBXW2 (26 products)
     antibodies-online kits for FBXW2 (20 products)
     antibodies-online peptides for FBXW2
     antibodies-online proteins for FBXW2 (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXW2 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4