Aliases for FBXW2 Gene
Aliases for FBXW2 Gene
External Ids for FBXW2 Gene
- HGNC: 13608
- Entrez Gene: 26190
- Ensembl: ENSG00000119402
- OMIM: 609071
- UniProtKB: Q9UKT8
Previous GeneCards Identifiers for FBXW2 Gene
- GC09M114631
- GC09M115160
- GC09M116980
- GC09M118902
- GC09M120606
- GC09M122566
- GC09M123514
- GC09M093137
Summaries for FBXW2 Gene
-
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXW2 Gene
FBXW2 (F-Box And WD Repeat Domain Containing 2) is a Protein Coding gene. Diseases associated with FBXW2 include Intestinal Botulism and Wound Botulism. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXW10.
UniProtKB/Swiss-Prot for FBXW2 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW2 Gene
Genomics for FBXW2 Gene
Regulatory Elements for FBXW2 Gene
Enhancers for FBXW2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G120923 | 2 | FANTOM5 Ensembl ENCODE dbSUPER | 12 | -137.4 | -137372 | 15.2 | HDGF FOXA2 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 | PSMD5-AS1 TRAF1 PSMD5 FBXW2 LOC100288842 CNTRL |
| GH09G120888 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 1.8 | -98.4 | -98408 | 7.0 | HDGF ATF1 PKNOX1 WRNIP1 YY1 TCF12 GATA2 ZNF143 FOS ZNF263 | TRAF1 PSMD5-AS1 PSMD5 FBXW2 CNTRL PHF19 PIR42449 |
| GH09G120783 | 1.4 | FANTOM5 Ensembl ENCODE | 2.3 | +9.6 | 9566 | 1.0 | ELF3 TBP SOX13 PKNOX1 MXI1 FOXA2 MAX CEBPG RFX5 RCOR1 | MEGF9 TRAF1 FBXW2 PIR59216 AHCYP2 |
| GH09G120474 | 1 | FANTOM5 Ensembl ENCODE | 2.5 | +318.2 | 318172 | 1.8 | BACH1 CEBPB CEBPG | MEGF9 FBXW2 PIR42824 GC09P120416 |
| GH09G120918 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 1.3 | -126.5 | -126509 | 2.5 | YY1 ZNF143 RELB IKZF2 CREM SMARCA5 CEBPB GATAD2B NR2F2 SP1 | PSMD5-AS1 TRAF1 FBXW2 PHF19 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXW2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXW2 gene promoter:
Regulatory Element Products
Genomic Location for FBXW2 Gene
- Chromosome:
- 9
- Start:
- 120,751,978 bp from pter
- End:
- 120,793,462 bp from pter
- Size:
- 41,485 bases
- Orientation:
- Minus strand
Genomic View for FBXW2 Gene
Genes around FBXW2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q33.2 by Ensembl
- 9q33.2 by Entrez Gene
- 9q33.2 by HGNC
FBXW2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXW2 Gene
Proteins for FBXW2 Gene
-
Protein details for FBXW2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKT8-FBXW2_HUMAN
- Recommended name:
- F-box/WD repeat-containing protein 2
- Protein Accession:
- Q9UKT8
- B3KRL8
- Q4VXH2
- Q7Z4V6
- Q8WV51
- Q9HA09
- Q9UKA3
Protein attributes for FBXW2 Gene
- Size:
- 454 amino acids
- Molecular mass:
- 51512 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
- SequenceCaution:
-
- Sequence=AAF04465.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAF13226.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97276.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97280.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305};
Protein Expression for FBXW2 Gene
Post-translational modifications for FBXW2 Gene
Other Protein References for FBXW2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXW2
- Invitrogen Antibodies for FBXW2
- antibodies-online Antibodies for FBXW2: See all 40
- GeneTex FBXW2 antibody for FBXW2
- GeneTex Edar antibody for FBXW2
Protein Products
-
OriGene Purified Proteins for FBXW2
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXW2
- Origene Custom Protein Services for FBXW2
- antibodies-online Proteins for FBXW2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXW2
-
ProSci Proteins for FBXW2
Assay Products
- antibodies-online Kits for FBXW2: See all 15
No data available for DME Specific Peptides for FBXW2 Gene
Domains & Families for FBXW2 Gene
Gene Families for FBXW2 Gene
Protein Domains for FBXW2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXW2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXW2 Gene
Function for FBXW2 Gene
Molecular function for FBXW2 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS,EXP | -- |
| GO:0005515 | protein binding | IPI | 11238952 |
Phenotypes for FBXW2 Gene
- GenomeRNAi human phenotypes for FBXW2:
-
- Decreased viability
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased POU5F1-GFP protein expression
- Increased G1 DNA content
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased influenza A/WSN/33 replication
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXW2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW2 gene
- Search ViGene Biosciences for FBXW2
CRISPR Products
-
OriGene CRISPR knockouts for FBXW2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXW2
- GenScript: Design CRISPR guide RNA sequences for FBXW2
miRNA for FBXW2 Gene
- miRTarBase miRNAs that target FBXW2
-
- hsa-mir-215-5p (MIRT024395)
- hsa-mir-192-5p (MIRT026356)
- hsa-mir-484 (MIRT041688)
- hsa-mir-106b-5p (MIRT044308)
- hsa-mir-222-3p (MIRT046735)
- hsa-let-7b-5p (MIRT052115)
- hsa-let-7a-5p (MIRT052421)
- hsa-mir-218-5p (MIRT440650)
- hsa-mir-6513-5p (MIRT523704)
- hsa-mir-887-5p (MIRT523705)
- hsa-mir-3913-5p (MIRT523706)
- hsa-mir-3122 (MIRT523707)
- hsa-mir-450a-1-3p (MIRT523708)
- hsa-mir-6780a-5p (MIRT523709)
- hsa-mir-6779-5p (MIRT523710)
- hsa-mir-3689c (MIRT523711)
- hsa-mir-3689b-3p (MIRT523712)
- hsa-mir-3689a-3p (MIRT523713)
- hsa-mir-30b-3p (MIRT523714)
- hsa-mir-1273h-5p (MIRT523715)
- hsa-mir-6788-5p (MIRT523716)
- hsa-mir-30c-2-3p (MIRT523717)
- hsa-mir-30c-1-3p (MIRT523718)
- hsa-mir-6866-5p (MIRT523719)
- hsa-mir-4451 (MIRT523720)
- hsa-mir-6799-5p (MIRT523721)
- hsa-mir-6883-5p (MIRT523722)
- hsa-mir-6785-5p (MIRT523723)
- hsa-mir-4728-5p (MIRT523724)
- hsa-mir-149-3p (MIRT523725)
- hsa-mir-7106-5p (MIRT523726)
- hsa-mir-98-5p (MIRT523727)
- hsa-mir-4500 (MIRT523728)
- hsa-mir-4458 (MIRT523729)
- hsa-let-7i-5p (MIRT523730)
- hsa-let-7g-5p (MIRT523731)
- hsa-let-7f-5p (MIRT523732)
- hsa-let-7e-5p (MIRT523733)
- hsa-let-7d-5p (MIRT523734)
- hsa-let-7c-5p (MIRT523735)
- hsa-mir-6087 (MIRT523736)
- hsa-mir-7112-5p (MIRT523737)
- hsa-mir-589-3p (MIRT523738)
- hsa-mir-6831-5p (MIRT523739)
- hsa-mir-3927-3p (MIRT523740)
- hsa-mir-1273e (MIRT624914)
- hsa-mir-7160-5p (MIRT624915)
- hsa-mir-4722-5p (MIRT624916)
- hsa-mir-6086 (MIRT624917)
- hsa-mir-377-5p (MIRT624918)
- hsa-mir-655-5p (MIRT624919)
- hsa-mir-6884-5p (MIRT624920)
- hsa-mir-485-5p (MIRT624921)
- hsa-mir-1827 (MIRT624922)
- hsa-mir-7162-3p (MIRT624923)
- hsa-mir-4649-3p (MIRT624924)
- hsa-mir-6840-3p (MIRT624925)
- hsa-mir-665 (MIRT624926)
- hsa-mir-4459 (MIRT624927)
- hsa-mir-4768-3p (MIRT624928)
- hsa-mir-4478 (MIRT624929)
- hsa-mir-4419b (MIRT624930)
- hsa-mir-3929 (MIRT624931)
- hsa-mir-940 (MIRT624932)
- hsa-mir-6893-5p (MIRT624933)
- hsa-mir-6808-5p (MIRT624934)
- hsa-mir-4695-5p (MIRT624935)
miRNA Products
- Search ViGene Biosciences for FBXW2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXW2
- Browse OriGene Inhibitory RNA Products For FBXW2
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW2 gene
Clone Products
-
OriGene ORF clones in human for FBXW2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FBXW2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FBXW2
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXW2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXW2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXW2 Gene
Localization for FBXW2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| peroxisome | 2 |
| plasma membrane | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXW2 Gene
Pathways & Interactions for FBXW2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Chaperonin-mediated protein folding |
.94
|
|
| 3 | Wnt Signaling Pathway and Pluripotency | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Metabolism of proteins | ||
Pathways by source for FBXW2 Gene
2 BioSystems pathways for FBXW2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0006464 | cellular protein modification process | TAS | 10531035 |
| GO:0006508 | proteolysis | TAS | 10531035 |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXW2 Gene
Transcripts for FBXW2 Gene
mRNA/cDNA for FBXW2 Gene
- (9) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (315) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXW2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXW2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXW2
- GenScript: Design CRISPR guide RNA sequences for FBXW2
miRNA Products
- Search ViGene Biosciences for FBXW2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXW2
- Browse OriGene Inhibitory RNA Products For FBXW2
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW2 gene
Clone Products
-
OriGene ORF clones in human for FBXW2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FBXW2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | · | 3g | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
Expression for FBXW2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (17.2), Testis (10.1), Breast (8.3), Salivary gland (8.1), Blymphocyte (7.0), and Prostate (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXW2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXW2 Gene:
FBXW2SOURCE GeneReport for Unigene cluster for FBXW2 Gene:
Hs.494985Evidence on tissue expression from TISSUES for FBXW2 Gene
- Nervous system(4.8)
- Lung(4.4)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXW2
-
OriGene qPCR primer pairs for FBXW2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW2 Gene
Orthologs for FBXW2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXW2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXW2 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXW2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Fbxw2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxw2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXW2 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | FBXW2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXW2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxw2 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | fbxw2-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxw2 34 35 |
|
||
| Dr.7935 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2865 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MET30 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7775 35 |
|
ManyToMany |
- Species where no ortholog for FBXW2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXW2 Gene
Paralogs for FBXW2 Gene
(3) SIMAP similar genes for FBXW2 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for FBXW2 Gene
Variants for FBXW2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000019735 | -- | 120,781,690(+) | CACAC(A/G)TATAT | intron-variant | |
| rs1000062259 | -- | 120,767,659(+) | AGTGA(A/G)TAAGA | intron-variant | |
| rs1000132193 | -- | 120,766,419(+) | CATGT(G/T)CAAGG | intron-variant | |
| rs1000201372 | -- | 120,785,241(+) | CTGGG(A/C)TCACA | intron-variant | |
| rs1000266940 | -- | 120,762,911(+) | AAGAG(C/T)GGCTG | utr-variant-3-prime |
Residual Variation Intolerance Score:
36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.45;
9.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXW2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXW2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW2 Gene
Disorders for FBXW2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| intestinal botulism |
|
|
| wound botulism |
|
|
| infant botulism |
|
|
| miller-dieker lissencephaly syndrome |
|
|
Search FBXW2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FBXW2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXW2
No data available for UniProtKB/Swiss-Prot and Genatlas for FBXW2 Gene
Publications for FBXW2 Gene
- Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 2 3 22 64
- Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
- Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PMID: 18703417) Chiang M.H. … Chen H. (Biol. Reprod. 2008) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 3 4 64
Products for FBXW2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FBXW2
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXW2
- Origene Custom Protein Services for FBXW2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXW2
- Browse OriGene Inhibitory RNA Products For FBXW2
- OriGene qPCR primer pairs and template standards for FBXW2
- OriGene qPCR primer pairs for FBXW2
- OriGene CRISPR knockouts for FBXW2
- OriGene ORF clones in human for FBXW2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FBXW2
- GenScript: Next-day shipping cDNA ORF clone for FBXW2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FBXW2
- GenScript Custom Assay Services for FBXW2
- GenScript Custom overexpressing Cell Line Services for FBXW2
- GenScript: Design CRISPR guide RNA sequences for FBXW2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FBXW2
- Sino Biological Human cDNA Clone for FBXW2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FBXW2
- Novus Biologicals proteins and lysates for FBXW2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FBXW2: See all 40
- antibodies-online Kits for FBXW2: See all 15
- antibodies-online Proteins for FBXW2: See all 5
- Search antibodies-online for peptides
- GeneTex Edar antibody for FBXW2
- GeneTex FBXW2 antibody for FBXW2
- Search GeneTex for Proteins for FBXW2
- ViGene Biosciences adenoviral particle packaged cDNA for FBXW2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBXW2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FBXW2 gene
- Search ViGene Biosciences for FBXW2
- Search Santa Cruz Biotechnology (SCBT) for FBXW2 Antibodies
- Search Santa Cruz Biotechnology (SCBT) for FBXW2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FBXW2
- Search for FBXW2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for FBXW2
- Horizon Cell Lines for FBXW2
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXW2
- VectorBuilder custom plasmid, inducible vectors for FBXW2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXW2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXW2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer