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Aliases for FBXW2 Gene

Aliases for FBXW2 Gene

  • F-Box And WD Repeat Domain Containing 2 2 3 5
  • F-Box And WD-40 Domain-Containing Protein 2 3 4
  • F-Box And WD-40 Domain Protein 2 2 3
  • Fwd2 3 4
  • FBW2 3 4
  • F-Box/WD Repeat-Containing Protein 2 3
  • Protein MD6 4
  • Md6 3

External Ids for FBXW2 Gene

Previous GeneCards Identifiers for FBXW2 Gene

  • GC09M114631
  • GC09M115160
  • GC09M116980
  • GC09M118902
  • GC09M120606
  • GC09M122566
  • GC09M123514
  • GC09M093137

Summaries for FBXW2 Gene

Entrez Gene Summary for FBXW2 Gene

  • F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW2 Gene

FBXW2 (F-Box And WD Repeat Domain Containing 2) is a Protein Coding gene. Diseases associated with FBXW2 include Intestinal Botulism and Wound Botulism. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXW7.

UniProtKB/Swiss-Prot for FBXW2 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Wiki entry for FBXW2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW2 Gene

Genomics for FBXW2 Gene

Regulatory Elements for FBXW2 Gene

Enhancers for FBXW2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FBXW2 on UCSC Golden Path with GeneCards custom track

Promoters for FBXW2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FBXW2 Gene

120,751,978 bp from pter
120,793,462 bp from pter
41,485 bases
Minus strand

Genomic View for FBXW2 Gene

Genes around FBXW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW2 Gene

Proteins for FBXW2 Gene

  • Protein details for FBXW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/WD repeat-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KRL8
    • Q4VXH2
    • Q7Z4V6
    • Q8WV51
    • Q9HA09
    • Q9UKA3

    Protein attributes for FBXW2 Gene

    454 amino acids
    Molecular mass:
    51512 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=AAF04465.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAF13226.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97276.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97280.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW2 Gene


neXtProt entry for FBXW2 Gene

Post-translational modifications for FBXW2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXW2 Gene

Domains & Families for FBXW2 Gene

Suggested Antigen Peptide Sequences for FBXW2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 7 WD repeats.
  • Contains 1 F-box domain.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FBXW2: view

Function for FBXW2 Gene

Molecular function for FBXW2 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding IPI 11238952
genes like me logo Genes that share ontologies with FBXW2: view
genes like me logo Genes that share phenotypes with FBXW2: view

Animal Model Products

CRISPR Products

miRNA for FBXW2 Gene

miRTarBase miRNAs that target FBXW2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXW2 Gene

Localization for FBXW2 Gene

Subcellular locations from

Jensen Localization Image for FBXW2 Gene COMPARTMENTS Subcellular localization image for FBXW2 gene
Compartment Confidence
cytosol 2
peroxisome 2
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXW2 Gene

Pathways & Interactions for FBXW2 Gene

genes like me logo Genes that share pathways with FBXW2: view

Gene Ontology (GO) - Biological Process for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10531035
GO:0006508 proteolysis TAS 10531035
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXW2: view

No data available for SIGNOR curated interactions for FBXW2 Gene

Drugs & Compounds for FBXW2 Gene

No Compound Related Data Available

Transcripts for FBXW2 Gene

Unigene Clusters for FBXW2 Gene

F-box and WD repeat domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP11: -

Relevant External Links for FBXW2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXW2 Gene

mRNA expression in normal human tissues for FBXW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXW2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.2), Testis (10.1), Breast (8.3), Salivary gland (8.1), Blymphocyte (7.0), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXW2 Gene

Protein tissue co-expression partners for FBXW2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXW2 Gene:


SOURCE GeneReport for Unigene cluster for FBXW2 Gene:

genes like me logo Genes that share expression patterns with FBXW2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXW2 Gene

Orthologs for FBXW2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXW2 34
  • 95.15 (n)
  • 99.56 (a)
FBXW2 35
  • 100 (a)
(Canis familiaris)
Mammalia FBXW2 34
  • 96.55 (n)
  • 100 (a)
FBXW2 35
  • 100 (a)
(Mus musculus)
Mammalia Fbxw2 34
  • 95.81 (n)
  • 98.68 (a)
Fbxw2 16
Fbxw2 35
  • 98 (a)
(Pan troglodytes)
Mammalia FBXW2 34
  • 99.71 (n)
  • 100 (a)
FBXW2 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxw2 34
  • 95.23 (n)
  • 98.68 (a)
(Monodelphis domestica)
Mammalia FBXW2 35
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 9 (a)
-- 35
  • 92 (a)
-- 35
  • 96 (a)
(Gallus gallus)
Aves FBXW2 34
  • 84.65 (n)
  • 93.83 (a)
FBXW2 35
  • 94 (a)
(Anolis carolinensis)
Reptilia FBXW2 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw2 34
  • 78.34 (n)
  • 88.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia fbxw2-prov 34
(Danio rerio)
Actinopterygii Dr.7935 34
fbxw2 34
  • 71.81 (n)
  • 79.52 (a)
fbxw2 35
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2865 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET30 35
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7775 35
  • 19 (a)
Species where no ortholog for FBXW2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW2 Gene

Gene Tree for FBXW2 (if available)
Gene Tree for FBXW2 (if available)

Paralogs for FBXW2 Gene

(3) SIMAP similar genes for FBXW2 Gene using alignment to 3 proteins: Pseudogenes for FBXW2 Gene

genes like me logo Genes that share paralogs with FBXW2: view

Variants for FBXW2 Gene

Sequence variations from dbSNP and Humsavar for FBXW2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs382400 -- 120,791,402(-) agtgg(C/G)tgaat intron-variant
rs384995 -- 120,785,938(-) gggtt(A/C/T)gagtc intron-variant
rs730804 -- 120,761,096(+) TCCAC(C/T)GGAGG utr-variant-3-prime
rs117212564 -- 120,789,107(+) AGACA(C/T)TATCA intron-variant
rs117219809 -- 120,767,121(+) ACTGG(C/G)CAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW2 Gene

Variant ID Type Subtype PubMed ID
nsv517321 CNV loss 19592680
nsv526071 CNV loss 19592680
nsv7434 OTHER inversion 18451855
nsv950935 CNV duplication 24416366

Variation tolerance for FBXW2 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXW2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW2 Gene

Disorders for FBXW2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FBXW2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intestinal botulism
  • intestinal colonization botulism
wound botulism
  • cutaneous infectious botulism
infant botulism
  • infant intestinal botulism
foodborne botulism
  • intoxication botulism
miller-dieker lissencephaly syndrome
  • mds
- elite association - COSMIC cancer census association via MalaCards
Search FBXW2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FBXW2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FBXW2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXW2 Gene

Publications for FBXW2 Gene

  1. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 2 3 22 65
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 65
  3. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PMID: 18703417) Chiang M.H. … Chen H. (Biol. Reprod. 2008) 3 22 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 3 4 65

Products for FBXW2 Gene

Sources for FBXW2 Gene

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