Aliases for FBXW2 Gene
External Ids for FBXW2 Gene
Previous GeneCards Identifiers for FBXW2 Gene
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXW2 Gene
FBXW2 (F-Box And WD Repeat Domain Containing 2) is a Protein Coding gene. Diseases associated with FBXW2 include Intestinal Botulism and Wound Botulism. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXW7.
UniProtKB/Swiss-Prot for FBXW2 Gene
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.