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Aliases for FBXW12 Gene

Aliases for FBXW12 Gene

  • F-Box And WD Repeat Domain Containing 12 2 3 5
  • F-Box Only Protein 35 2 3 4
  • F-Box And WD-40 Domain-Containing Protein 12 3 4
  • F-Box And WD-40 Domain Protein 12 2 3
  • FBXO35 3 4
  • FBXO12 3 4
  • FBW12 3 4
  • F-Box- And WD40-Repeat-Containing Protein 3
  • F-Box/WD Repeat-Containing Protein 12 3

External Ids for FBXW12 Gene

Previous HGNC Symbols for FBXW12 Gene

  • FBXO35

Previous GeneCards Identifiers for FBXW12 Gene

  • GC03P048388

Summaries for FBXW12 Gene

Entrez Gene Summary for FBXW12 Gene

  • Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW12 Gene

FBXW12 (F-Box And WD Repeat Domain Containing 12) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for FBXW12 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW12 Gene

Genomics for FBXW12 Gene

Regulatory Elements for FBXW12 Gene

Enhancers for FBXW12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F048551 1.5 FANTOM5 ENCODE 10.3 +187.1 187096 15.4 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 TMA7 WDR6 NICN1 FCF1P2 COL7A1 MIR711 ATRIP ENSG00000244380 CCDC51 FBXW12
GH03F048232 1.2 Ensembl ENCODE 11 -139.3 -139285 1.4 ARID4B ZNF2 ZNF207 ZNF143 DEK REST ZNF518A ZNF623 KAT8 SMARCA4 CDC25A FBXW12 NME6 RNU7-128P NDUFB1P1 ZNF589 MRPS18AP1 CAMP GC03M048234
GH03F048464 1.2 ENCODE 10.5 +97.9 97914 11.4 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TMA7 ATRIP SHISA5 ENSG00000223343 ENSG00000244380 CCDC51 PLXNB1 MIR711 COL7A1 PFKFB4
GH03F048235 1.1 Ensembl ENCODE 11 -135.5 -135474 1.8 ELF3 PKNOX1 ZNF133 FEZF1 THRB RARA SCRT2 THAP11 ZEB2 ZNF341 CDC25A FBXW12 NDUFB1P1 RNU7-128P PLXNB1 NME6 CCDC51 TMA7 ATRIP ENSG00000244380
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXW12 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXW12 Gene

48,372,175 bp from pter
48,401,259 bp from pter
29,085 bases
Plus strand

Genomic View for FBXW12 Gene

Genes around FBXW12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW12 Gene

Proteins for FBXW12 Gene

  • Protein details for FBXW12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/WD repeat-containing protein 12
    Protein Accession:
    Secondary Accessions:
    • E9PG36
    • Q494Y9
    • Q494Z0

    Protein attributes for FBXW12 Gene

    464 amino acids
    Molecular mass:
    53056 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXW12 Gene


neXtProt entry for FBXW12 Gene

Post-translational modifications for FBXW12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW12 Gene

No data available for DME Specific Peptides for FBXW12 Gene

Domains & Families for FBXW12 Gene

Protein Domains for FBXW12 Gene

Suggested Antigen Peptide Sequences for FBXW12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 5 WD repeats.
  • Contains 1 F-box domain.
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with FBXW12: view

Function for FBXW12 Gene

Molecular function for FBXW12 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXW12: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW12 Gene

Localization for FBXW12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW12 gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXW12 Gene

Pathways & Interactions for FBXW12 Gene

genes like me logo Genes that share pathways with FBXW12: view

Interacting Proteins for FBXW12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000296438 Q6X9E4-FBW12_HUMAN for FBXW12 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FBXW12 Gene


No data available for SIGNOR curated interactions for FBXW12 Gene

Transcripts for FBXW12 Gene

mRNA/cDNA for FBXW12 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXW12 Gene

F-box and WD repeat domain containing 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for FBXW12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXW12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXW12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW12 Gene

This gene is overexpressed in Pancreas (x18.4).

Protein differential expression in normal tissues from HIPED for FBXW12 Gene

This gene is overexpressed in Monocytes (40.0) and Adrenal (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXW12 Gene

Protein tissue co-expression partners for FBXW12 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXW12 Gene:


SOURCE GeneReport for Unigene cluster for FBXW12 Gene:


mRNA Expression by UniProt/SwissProt for FBXW12 Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with FBXW12: view

Primer Products

Orthologs for FBXW12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXW12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXW12 34 35
  • 99.24 (n)
(Canis familiaris)
Mammalia FBXW12 34 35
  • 74.96 (n)
(Rattus norvegicus)
Mammalia Fbxw12 34
  • 59.5 (n)
(Mus musculus)
Mammalia Fbxw25 35
  • 43 (a)
Fbxw20 35
  • 41 (a)
Fbxw22 35
  • 41 (a)
Fbxw26 35
  • 41 (a)
Fbxw13 35
  • 40 (a)
Fbxw16 35
  • 40 (a)
Fbxw18 35
  • 40 (a)
Fbxw19 35
  • 40 (a)
Fbxw24 35
  • 40 (a)
Fbxw14 35
  • 39 (a)
Fbxw21 35
  • 39 (a)
Fbxw28 35
  • 39 (a)
Fbxw15 35
  • 37 (a)
(Monodelphis domestica)
Mammalia FBXW12 35
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia FBXW12 35
  • 35 (a)
(Bos Taurus)
Mammalia FBXW12 35
  • 34 (a)
(Anolis carolinensis)
Reptilia FBXW12 35
  • 33 (a)
(Danio rerio)
Actinopterygii FBXW12 35
  • 29 (a)
Species where no ortholog for FBXW12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW12 Gene

Gene Tree for FBXW12 (if available)
Gene Tree for FBXW12 (if available)

Paralogs for FBXW12 Gene Pseudogenes for FBXW12 Gene

genes like me logo Genes that share paralogs with FBXW12: view

No data available for Paralogs for FBXW12 Gene

Variants for FBXW12 Gene

Sequence variations from dbSNP and Humsavar for FBXW12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10565492 -- 48,371,182(+) TTTGC(-/CT)CTTTC upstream-variant-2KB
rs111279174 -- 48,381,825(+) CTGGC(C/T)TCCTG reference, missense
rs111283111 -- 48,394,291(+) CTCTA(A/C)TCATC intron-variant
rs111284235 -- 48,385,125(+) TCCCC(-/CT)CTCTC intron-variant
rs111391561 -- 48,393,452(+) ACCTG(C/G)GCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW12 Gene

Variant ID Type Subtype PubMed ID
esv3596107 CNV loss 21293372
nsv590242 CNV loss 21841781
nsv834683 CNV gain 17160897
nsv834684 CNV gain 17160897

Variation tolerance for FBXW12 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXW12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW12 Gene

Disorders for FBXW12 Gene

Relevant External Links for FBXW12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXW12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW12 Gene

Publications for FBXW12 Gene

  1. cDNA cloning and expression analysis of a novel human F-box domain containing gene. (PMID: 15040455) Zeng L. … Mao Y. (Mol. Biol. Rep. 2004) 2 3 4 64
  2. FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer. (PMID: 26617728) De La Chesnaye E. … Ojeda S.R. (Int J Clin Exp Pathol 2015) 3 64
  3. The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor. (PMID: 26171402) Franz J. … Weathington N.M. (J Immunol Res 2015) 3 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for FBXW12 Gene

Sources for FBXW12 Gene

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