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Aliases for FBXW12 Gene

Aliases for FBXW12 Gene

  • F-Box And WD Repeat Domain Containing 12 2 3 5
  • F-Box Only Protein 35 2 3 4
  • F-Box And WD-40 Domain-Containing Protein 12 3 4
  • F-Box And WD-40 Domain Protein 12 2 3
  • FBXO35 3 4
  • FBXO12 3 4
  • FBW12 3 4
  • F-Box- And WD40-Repeat-Containing Protein 3
  • F-Box/WD Repeat-Containing Protein 12 3

External Ids for FBXW12 Gene

Previous HGNC Symbols for FBXW12 Gene

  • FBXO35

Previous GeneCards Identifiers for FBXW12 Gene

  • GC03P048388

Summaries for FBXW12 Gene

Entrez Gene Summary for FBXW12 Gene

  • Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW12 Gene

FBXW12 (F-Box And WD Repeat Domain Containing 12) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for FBXW12 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXW12 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW12 Gene

Genomics for FBXW12 Gene

GeneHancer (GH) Regulatory Elements for FBXW12 Gene

Promoters and enhancers for FBXW12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I048372 Enhancer 0.5 ENCODE 550.8 +1.0 987 0.8 ZNF316 HLF IKZF1 MAFK EMSY FBXW12 TMA7 RN7SL321P
GH03I048373 Promoter 0.5 EPDnew 550.8 +0.1 110 0.1 FBXW12 RN7SL321P
GH03I048551 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +187.1 187095 15.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PFKFB4 UCN2 TMA7 NME6 QRICH1 ATRIP USP19 ZNF589 WDR6 TMEM89
GH03I048424 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.9 +58.5 58452 12.1 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 PLXNB1 LOC105377077 TMA7 SHISA5 FBXW12 NME6 SPINK8 CDC25A RNU7-128P NDUFB1P1
GH03I048464 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +97.9 97914 11.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SHISA5 TREX1 TMA7 ATRIP NME6 QRICH1 USP19 MRPS18AP1 TMEM89 RHOA-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXW12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXW12 gene promoter:

Genomic Locations for FBXW12 Gene

Genomic Locations for FBXW12 Gene
29,085 bases
Plus strand

Genomic View for FBXW12 Gene

Genes around FBXW12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW12 Gene

Proteins for FBXW12 Gene

  • Protein details for FBXW12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/WD repeat-containing protein 12
    Protein Accession:
    Secondary Accessions:
    • E9PG36
    • Q494Y9
    • Q494Z0

    Protein attributes for FBXW12 Gene

    464 amino acids
    Molecular mass:
    53056 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXW12 Gene


neXtProt entry for FBXW12 Gene

Post-translational modifications for FBXW12 Gene

No Post-translational modifications

Other Protein References for FBXW12 Gene

No data available for DME Specific Peptides for FBXW12 Gene

Domains & Families for FBXW12 Gene

Gene Families for FBXW12 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for FBXW12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXW12: view

No data available for UniProtKB/Swiss-Prot for FBXW12 Gene

Function for FBXW12 Gene

Molecular function for FBXW12 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXW12 Gene

Gene Ontology (GO) - Molecular Function for FBXW12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXW12: view
genes like me logo Genes that share phenotypes with FBXW12: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW12 Gene

Localization for FBXW12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW12 gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FBXW12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXW12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXW12 Gene

Pathways & Interactions for FBXW12 Gene

genes like me logo Genes that share pathways with FBXW12: view

Interacting Proteins for FBXW12 Gene

Gene Ontology (GO) - Biological Process for FBXW12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXW12: view

No data available for SIGNOR curated interactions for FBXW12 Gene

Drugs & Compounds for FBXW12 Gene

No Compound Related Data Available

Transcripts for FBXW12 Gene

mRNA/cDNA for FBXW12 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXW12 Gene

F-box and WD repeat domain containing 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for FBXW12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXW12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXW12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW12 Gene

This gene is overexpressed in Pancreas (x18.4).

Protein differential expression in normal tissues from HIPED for FBXW12 Gene

This gene is overexpressed in Monocytes (40.0) and Adrenal (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXW12 Gene

Protein tissue co-expression partners for FBXW12 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXW12 Gene:


SOURCE GeneReport for Unigene cluster for FBXW12 Gene:


mRNA Expression by UniProt/SwissProt for FBXW12 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for FBXW12 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with FBXW12: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW12 Gene

Orthologs for FBXW12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXW12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXW12 33 34
  • 99.24 (n)
(Canis familiaris)
Mammalia FBXW12 33 34
  • 74.96 (n)
(Rattus norvegicus)
Mammalia Fbxw12 33
  • 59.5 (n)
(Mus musculus)
Mammalia Fbxw25 34
  • 43 (a)
Fbxw20 34
  • 41 (a)
Fbxw22 34
  • 41 (a)
Fbxw26 34
  • 41 (a)
Fbxw13 34
  • 40 (a)
Fbxw16 34
  • 40 (a)
Fbxw18 34
  • 40 (a)
Fbxw19 34
  • 40 (a)
Fbxw24 34
  • 40 (a)
Fbxw14 34
  • 39 (a)
Fbxw21 34
  • 39 (a)
Fbxw28 34
  • 39 (a)
Fbxw15 34
  • 37 (a)
(Monodelphis domestica)
Mammalia FBXW12 34
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia FBXW12 34
  • 35 (a)
(Bos Taurus)
Mammalia FBXW12 34
  • 34 (a)
(Anolis carolinensis)
Reptilia FBXW12 34
  • 33 (a)
(Danio rerio)
Actinopterygii FBXW12 34
  • 29 (a)
Species where no ortholog for FBXW12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW12 Gene

Gene Tree for FBXW12 (if available)
Gene Tree for FBXW12 (if available)

Paralogs for FBXW12 Gene Pseudogenes for FBXW12 Gene

genes like me logo Genes that share paralogs with FBXW12: view

No data available for Paralogs for FBXW12 Gene

Variants for FBXW12 Gene

Sequence variations from dbSNP and Humsavar for FBXW12 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000033582 -- 48,380,690(+) T/C intron_variant
rs1000089258 -- 48,388,822(+) C/G intron_variant
rs1000284416 -- 48,374,019(+) T/C intron_variant
rs1000284554 -- 48,372,032(+) A/C upstream_transcript_variant
rs1000378133 -- 48,394,148(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW12 Gene

Variant ID Type Subtype PubMed ID
esv3596107 CNV loss 21293372
nsv590242 CNV loss 21841781
nsv834683 CNV gain 17160897
nsv834684 CNV gain 17160897

Variation tolerance for FBXW12 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXW12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW12 Gene

Disorders for FBXW12 Gene

Additional Disease Information for FBXW12

No disorders were found for FBXW12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW12 Gene

Publications for FBXW12 Gene

  1. cDNA cloning and expression analysis of a novel human F-box domain containing gene. (PMID: 15040455) Zeng L … Mao Y (Molecular biology reports 2004) 2 3 4 58
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  3. The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor. (PMID: 26171402) Franz J … Weathington NM (Journal of immunology research 2015) 3 58
  4. FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer. (PMID: 26617728) De La Chesnaye E … Ojeda SR (International journal of clinical and experimental pathology 2015) 3 58
  5. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. (PMID: 19028597) Ebstein F … Kloetzel PM (The international journal of biochemistry & cell biology 2009) 3 58

Products for FBXW12 Gene

Sources for FBXW12 Gene

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