Aliases for FBXW12 Gene
Aliases for FBXW12 Gene
External Ids for FBXW12 Gene
- HGNC: 20729
- Entrez Gene: 285231
- Ensembl: ENSG00000164049
- OMIM: 609075
- UniProtKB: Q6X9E4
Previous HGNC Symbols for FBXW12 Gene
- FBXO35
Previous GeneCards Identifiers for FBXW12 Gene
- GC03P048388
Summaries for FBXW12 Gene
-
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXW12 Gene
FBXW12 (F-Box And WD Repeat Domain Containing 12) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot for FBXW12 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW12 Gene
Genomics for FBXW12 Gene
Regulatory Elements for FBXW12 Gene
Enhancers for FBXW12 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXW12 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXW12 gene promoter:
Regulatory Element Products
Genomic Location for FBXW12 Gene
- Chromosome:
- 3
- Start:
- 48,372,175 bp from pter
- End:
- 48,401,259 bp from pter
- Size:
- 29,085 bases
- Orientation:
- Plus strand
Genomic View for FBXW12 Gene
Genes around FBXW12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by Ensembl
- 3p21.31 by Entrez Gene
- 3p21.31 by HGNC
FBXW12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXW12 Gene
Proteins for FBXW12 Gene
-
Protein details for FBXW12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6X9E4-FBW12_HUMAN
- Recommended name:
- F-box/WD repeat-containing protein 12
- Protein Accession:
- Q6X9E4
- E9PG36
- Q494Y9
- Q494Z0
Protein attributes for FBXW12 Gene
- Size:
- 464 amino acids
- Molecular mass:
- 53056 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
Protein Expression for FBXW12 Gene
Post-translational modifications for FBXW12 Gene
Other Protein References for FBXW12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXW12
- Novus Biologicals Antibodies for FBXW12
- Invitrogen Antibodies for FBXW12
- antibodies-online Antibodies for FBXW12: See all 40
- Search GeneTex for Antibodies for FBXW12
Protein Products
-
OriGene Purified Proteins for FBXW12
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXW12
- Origene Custom Protein Services for FBXW12
- Search GeneTex for Proteins for FBXW12
Assay Products
No data available for DME Specific Peptides for FBXW12 Gene
Domains & Families for FBXW12 Gene
Gene Families for FBXW12 Gene
Protein Domains for FBXW12 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXW12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXW12 Gene
Function for FBXW12 Gene
Molecular function for FBXW12 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
Phenotypes for FBXW12 Gene
- GenomeRNAi human phenotypes for FBXW12:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXW12 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for FBXW12
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXW12
- GenScript: Design CRISPR guide RNA sequences for FBXW12
miRNA Products
- Search ViGene Biosciences for FBXW12
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXW12
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW12 gene
Cell Line Products
-
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-
ViGene Biosciences adenoviral particle packaged cDNA for FBXW12 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW12 Gene
Localization for FBXW12 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXW12 Gene
Pathways & Interactions for FBXW12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXW12 Gene
4 Reactome pathways for FBXW12 Gene
Interacting Proteins for FBXW12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXW12 Gene
Transcripts for FBXW12 Gene
mRNA/cDNA for FBXW12 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXW12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXW12
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXW12
- GenScript: Design CRISPR guide RNA sequences for FBXW12
miRNA Products
- Search ViGene Biosciences for FBXW12
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXW12 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - |
Expression for FBXW12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
mRNA differential expression in normal tissues according to GTEx for FBXW12 Gene
This gene is overexpressed in Pancreas (x18.4).
This gene is overexpressed in Monocytes (40.0) and Adrenal (28.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXW12 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXW12 Gene:
FBXW12SOURCE GeneReport for Unigene cluster for FBXW12 Gene:
Hs.288793mRNA Expression by UniProt/SwissProt for FBXW12 Gene:
Q6X9E4-FBW12_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for FBXW12 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXW12
-
OriGene qPCR primer pairs for FBXW12
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW12 Gene
Orthologs for FBXW12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXW12 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXW12 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxw12 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxw25 35 |
|
OneToMany | |
| Fbxw20 35 |
|
OneToMany | |||
| Fbxw22 35 |
|
OneToMany | |||
| Fbxw26 35 |
|
OneToMany | |||
| Fbxw13 35 |
|
OneToMany | |||
| Fbxw16 35 |
|
OneToMany | |||
| Fbxw18 35 |
|
OneToMany | |||
| Fbxw19 35 |
|
OneToMany | |||
| Fbxw24 35 |
|
OneToMany | |||
| Fbxw14 35 |
|
OneToMany | |||
| Fbxw21 35 |
|
OneToMany | |||
| Fbxw28 35 |
|
OneToMany | |||
| Fbxw15 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | FBXW12 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXW12 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FBXW12 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FBXW12 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | FBXW12 35 |
|
OneToOne |
- Species where no ortholog for FBXW12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXW12 Gene
Pseudogenes.org Pseudogenes for FBXW12 Gene
No data available for Paralogs for FBXW12 Gene
Variants for FBXW12 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033582 | -- | 48,380,690(+) | TGCGA(C/T)GCTCT | intron-variant | |
| rs1000089258 | -- | 48,388,822(+) | TCGGG(C/G)TAATT | intron-variant | |
| rs1000284416 | -- | 48,374,019(+) | GAAAC(C/T)CTAAA | intron-variant | |
| rs1000284554 | -- | 48,372,032(+) | TTTTG(A/C)GAGGA | upstream-variant-2KB | |
| rs1000378133 | -- | 48,394,148(+) | GAGGC(C/T)AAGTT | intron-variant |
Residual Variation Intolerance Score:
56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.75;
57.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXW12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXW12
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW12 Gene
Disorders for FBXW12 Gene
Relevant External Links for FBXW12
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXW12
No disorders were found for FBXW12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW12 Gene
Publications for FBXW12 Gene
- cDNA cloning and expression analysis of a novel human F-box domain containing gene. (PMID: 15040455) Zeng L. … Mao Y. (Mol. Biol. Rep. 2004) 2 3 4 64
- The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor. (PMID: 26171402) Franz J. … Weathington N.M. (J Immunol Res 2015) 3 64
- FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer. (PMID: 26617728) De La Chesnaye E. … Ojeda S.R. (Int J Clin Exp Pathol 2015) 3 64
- Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. (PMID: 19028597) Ebstein F. … Kloetzel P.-M. (Int. J. Biochem. Cell Biol. 2009) 3 64
- The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
Products for FBXW12 Gene
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- Custom Antibody ServicesOriGene Antibodies for FBXW12
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- Novus Biologicals Antibodies for FBXW12
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- Mammalian expression: PiggyBac
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXW12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer