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Aliases for FBXW12 Gene

Aliases for FBXW12 Gene

  • F-Box And WD Repeat Domain Containing 12 2 3
  • F-Box Only Protein 35 2 3 4
  • FBXO35 3 4 6
  • FBXO12 3 4 6
  • FBW12 3 4 6
  • F-Box And WD-40 Domain-Containing Protein 12 3 4
  • F-Box And WD-40 Domain Protein 12 2 3
  • F-Box- And WD40-Repeat-Containing Protein 3
  • F-Box/WD Repeat-Containing Protein 12 3

External Ids for FBXW12 Gene

Previous HGNC Symbols for FBXW12 Gene

  • FBXO35

Previous GeneCards Identifiers for FBXW12 Gene

  • GC03P048388

Summaries for FBXW12 Gene

Entrez Gene Summary for FBXW12 Gene

  • Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW12 Gene

FBXW12 (F-Box And WD Repeat Domain Containing 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXW12 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW12 Gene

Genomics for FBXW12 Gene

Regulatory Elements for FBXW12 Gene

Genomic Location for FBXW12 Gene

Start:
48,372,219 bp from pter
End:
48,401,259 bp from pter
Size:
29,041 bases
Orientation:
Plus strand

Genomic View for FBXW12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXW12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW12 Gene

Proteins for FBXW12 Gene

  • Protein details for FBXW12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6X9E4-FBW12_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 12
    Protein Accession:
    Q6X9E4
    Secondary Accessions:
    • E9PG36
    • Q494Y9
    • Q494Z0

    Protein attributes for FBXW12 Gene

    Size:
    464 amino acids
    Molecular mass:
    53056 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXW12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW12 Gene

Proteomics data for FBXW12 Gene at MOPED

Post-translational modifications for FBXW12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW12 Gene

No data available for DME Specific Peptides for FBXW12 Gene

Domains for FBXW12 Gene

Gene Families for FBXW12 Gene

HGNC:
  • FBXW :F-boxes / WD-40 domains
  • WDR :WD repeat domain containing

Protein Domains for FBXW12 Gene

Suggested Antigen Peptide Sequences for FBXW12 Gene

Graphical View of Domain Structure for InterPro Entry

Q6X9E4

UniProtKB/Swiss-Prot:

FBW12_HUMAN :
  • Q6X9E4
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with FBXW12: view

Function for FBXW12 Gene

Molecular function for FBXW12 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXW12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXW12: view

Phenotypes for FBXW12 Gene

GenomeRNAi human phenotypes for FBXW12:
genes like me logo Genes that share phenotypes with FBXW12: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXW12 Gene

Localization for FBXW12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXW12 Gene COMPARTMENTS Subcellular localization image for FBXW12 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXW12 Gene

Pathways for FBXW12 Gene

SuperPathways for FBXW12 Gene

No Data Available

Interacting Proteins for FBXW12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296438%0d%0a9606.ENSP00000231487%0d%0a
Selected Interacting proteins: ENSP00000296438 for FBXW12 Gene via STRING

Symbol External ID(s) Details
SKP1

Gene Ontology (GO) - Biological Process for FBXW12 Gene

None

No data available for Pathways by source for FBXW12 Gene

Transcripts for FBXW12 Gene

mRNA/cDNA for FBXW12 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXW12 Gene

F-box and WD repeat domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for FBXW12 Gene

GeneLoc Exon Structure for
FBXW12
ECgene alternative splicing isoforms for
FBXW12

Expression for FBXW12 Gene

mRNA expression in normal human tissues for FBXW12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW12 Gene

This gene is overexpressed in Pancreas (18.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXW12 Gene

SOURCE GeneReport for Unigene cluster for FBXW12 Gene Hs.288793

mRNA Expression by UniProt/SwissProt for FBXW12 Gene

Q6X9E4-FBW12_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with FBXW12: view

Orthologs for FBXW12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXW12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW12 35
  • 99.24 (n)
  • 99.09 (a)
FBXW12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXW12 36
  • 34 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXW12 35
  • 74.96 (n)
  • 58.23 (a)
FBXW12 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxw13 36
  • 40 (a)
OneToMany
Fbxw14 36
  • 39 (a)
OneToMany
Fbxw15 36
  • 37 (a)
OneToMany
Fbxw16 36
  • 40 (a)
OneToMany
Fbxw18 36
  • 40 (a)
OneToMany
Fbxw19 36
  • 40 (a)
OneToMany
Fbxw20 36
  • 41 (a)
OneToMany
Fbxw21 36
  • 39 (a)
OneToMany
Fbxw22 36
  • 41 (a)
OneToMany
Fbxw23 16
Fbxw24 36
  • 40 (a)
OneToMany
Fbxw25 36
  • 43 (a)
OneToMany
Fbxw26 36
  • 41 (a)
OneToMany
Fbxw28 36
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FBXW12 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXW12 36
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxw12 35
  • 59.5 (n)
  • 43.02 (a)
lizard
(Anolis carolinensis)
Reptilia FBXW12 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FBXW12 36
  • 29 (a)
OneToOne
Species with no ortholog for FBXW12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW12 Gene

ENSEMBL:
Gene Tree for FBXW12 (if available)
TreeFam:
Gene Tree for FBXW12 (if available)

Paralogs for FBXW12 Gene

Pseudogenes.org Pseudogenes for FBXW12 Gene

genes like me logo Genes that share paralogs with FBXW12: view

No data available for Paralogs for FBXW12 Gene

Variants for FBXW12 Gene

Sequence variations from dbSNP and Humsavar for FBXW12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs725309 -- 48,377,218(-) gtgat(C/T)atcat intron-variant
rs725310 -- 48,377,081(-) ccatt(A/G)tagta intron-variant
rs898225 -- 48,371,689(+) AAGAA(G/T)GGTTG upstream-variant-2KB
rs1141758 -- 48,380,108(+) gcctg(A/G)gcaac intron-variant
rs1459242 -- 48,372,047(+) AACAC(C/T)CAGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXW12 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897
nsv834684 CNV Gain 17160897

Relevant External Links for FBXW12 Gene

HapMap Linkage Disequilibrium report
FBXW12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW12 Gene

Disorders for FBXW12 Gene

No disorders were found for FBXW12 Gene.

No data available for UniProtKB/Swiss-Prot for FBXW12 Gene

Publications for FBXW12 Gene

  1. cDNA cloning and expression analysis of a novel human F-box domain containing gene. (PMID: 15040455) Zeng L. … Mao Y. (Mol. Biol. Rep. 2004) 2 3 4
  2. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FBXW12 Gene

Sources for FBXW12 Gene

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