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Aliases for FBXW12 Gene

Aliases for FBXW12 Gene

  • F-Box And WD Repeat Domain Containing 12 2 3 5
  • F-Box Only Protein 35 2 3 4
  • F-Box And WD-40 Domain-Containing Protein 12 3 4
  • F-Box And WD-40 Domain Protein 12 2 3
  • FBXO35 3 4
  • FBXO12 3 4
  • FBW12 3 4
  • F-Box- And WD40-Repeat-Containing Protein 3

External Ids for FBXW12 Gene

Previous HGNC Symbols for FBXW12 Gene

  • FBXO35

Previous GeneCards Identifiers for FBXW12 Gene

  • GC03P048388

Summaries for FBXW12 Gene

Entrez Gene Summary for FBXW12 Gene

  • Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW12 Gene

FBXW12 (F-Box And WD Repeat Domain Containing 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXW12 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW12 Gene

Genomics for FBXW12 Gene

Regulatory Elements for FBXW12 Gene

Enhancers for FBXW12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXW12 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXW12 Gene

48,372,175 bp from pter
48,401,259 bp from pter
29,085 bases
Plus strand

Genomic View for FBXW12 Gene

Genes around FBXW12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW12 Gene

Proteins for FBXW12 Gene

  • Protein details for FBXW12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/WD repeat-containing protein 12
    Protein Accession:
    Secondary Accessions:
    • E9PG36
    • Q494Y9
    • Q494Z0

    Protein attributes for FBXW12 Gene

    464 amino acids
    Molecular mass:
    53056 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXW12 Gene


neXtProt entry for FBXW12 Gene

Proteomics data for FBXW12 Gene at MOPED

Post-translational modifications for FBXW12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW12 Gene

No data available for DME Specific Peptides for FBXW12 Gene

Domains & Families for FBXW12 Gene

Protein Domains for FBXW12 Gene

Suggested Antigen Peptide Sequences for FBXW12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 5 WD repeats.
  • Contains 1 F-box domain.
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with FBXW12: view

Function for FBXW12 Gene

Molecular function for FBXW12 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXW12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW12 Gene

Localization for FBXW12 Gene

Subcellular locations from

Jensen Localization Image for FBXW12 Gene COMPARTMENTS Subcellular localization image for FBXW12 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXW12 Gene

Pathways & Interactions for FBXW12 Gene

SuperPathways for FBXW12 Gene

No Data Available

Interacting Proteins for FBXW12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000296438 for FBXW12 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FBXW12 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXW12 Gene

Drugs & Compounds for FBXW12 Gene

No Compound Related Data Available

Transcripts for FBXW12 Gene

mRNA/cDNA for FBXW12 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXW12 Gene

F-box and WD repeat domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for FBXW12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXW12 Gene

mRNA expression in normal human tissues for FBXW12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW12 Gene

This gene is overexpressed in Pancreas (x18.4).

Protein differential expression in normal tissues from HIPED for FBXW12 Gene

This gene is overexpressed in Monocytes (40.0) and Adrenal (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXW12 Gene

SOURCE GeneReport for Unigene cluster for FBXW12 Gene Hs.288793

mRNA Expression by UniProt/SwissProt for FBXW12 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with FBXW12: view

Protein tissue co-expression partners for FBXW12 Gene

Primer Products

Orthologs for FBXW12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXW12 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FBXW12 35
  • 74.96 (n)
  • 58.23 (a)
FBXW12 36
  • 57 (a)
(Pan troglodytes)
Mammalia FBXW12 35
  • 99.24 (n)
  • 99.09 (a)
FBXW12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxw12 35
  • 59.5 (n)
  • 43.02 (a)
(Bos Taurus)
Mammalia FBXW12 36
  • 34 (a)
(Monodelphis domestica)
Mammalia FBXW12 36
  • 36 (a)
(Mus musculus)
Mammalia Fbxw13 36
  • 40 (a)
Fbxw14 36
  • 39 (a)
Fbxw15 36
  • 37 (a)
Fbxw16 36
  • 40 (a)
Fbxw18 36
  • 40 (a)
Fbxw19 36
  • 40 (a)
Fbxw20 36
  • 41 (a)
Fbxw21 36
  • 39 (a)
Fbxw22 36
  • 41 (a)
Fbxw24 36
  • 40 (a)
Fbxw25 36
  • 43 (a)
Fbxw26 36
  • 41 (a)
Fbxw28 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia FBXW12 36
  • 35 (a)
(Anolis carolinensis)
Reptilia FBXW12 36
  • 33 (a)
(Danio rerio)
Actinopterygii FBXW12 36
  • 29 (a)
Species with no ortholog for FBXW12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW12 Gene

Gene Tree for FBXW12 (if available)
Gene Tree for FBXW12 (if available)

Paralogs for FBXW12 Gene Pseudogenes for FBXW12 Gene

genes like me logo Genes that share paralogs with FBXW12: view

No data available for Paralogs for FBXW12 Gene

Variants for FBXW12 Gene

Sequence variations from dbSNP and Humsavar for FBXW12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17080138 - 48,372,784(+) ATTGC(C/T)TGACT intron-variant, reference, missense
rs6442117 - 48,378,407(+) TGGAT(C/T)GGAAA intron-variant, reference, missense
rs6784322 - 48,380,745(+) CAGTG(A/T)TCCTC reference, missense
rs725309 -- 48,377,218(-) gtgat(C/T)atcat intron-variant
rs725310 -- 48,377,081(-) ccatt(A/G)tagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW12 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV Gain 17160897
nsv834684 CNV Gain 17160897

Variation tolerance for FBXW12 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXW12 Gene

Disorders for FBXW12 Gene

Relevant External Links for FBXW12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXW12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW12 Gene

Publications for FBXW12 Gene

  1. cDNA cloning and expression analysis of a novel human F-box domain containing gene. (PMID: 15040455) Zeng L. … Mao Y. (Mol. Biol. Rep. 2004) 2 3 4 67
  2. The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor. (PMID: 26171402) Franz J. … Weathington N.M. (J Immunol Res 2015) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FBXW12 Gene

Sources for FBXW12 Gene