Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXW12 Gene

Aliases for FBXW12 Gene

  • F-Box And WD Repeat Domain Containing 12 2 3 5
  • F-Box Only Protein 35 2 3 4
  • F-Box And WD-40 Domain-Containing Protein 12 3 4
  • F-Box And WD-40 Domain Protein 12 2 3
  • FBXO35 3 4
  • FBXO12 3 4
  • FBW12 3 4
  • F-Box- And WD40-Repeat-Containing Protein 3
  • F-Box/WD Repeat-Containing Protein 12 3

External Ids for FBXW12 Gene

Previous HGNC Symbols for FBXW12 Gene

  • FBXO35

Previous GeneCards Identifiers for FBXW12 Gene

  • GC03P048388

Summaries for FBXW12 Gene

Entrez Gene Summary for FBXW12 Gene

  • Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW12 Gene

FBXW12 (F-Box And WD Repeat Domain Containing 12) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for FBXW12 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW12 Gene

Genomics for FBXW12 Gene

Regulatory Elements for FBXW12 Gene

Enhancers for FBXW12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G048551 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +187.1 187096 15.4 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 TMA7 WDR6 COL7A1 ATRIP ENSG00000244380 CCDC51 FBXW12 NME6 CDC25A NDUFB1P1
GH03G048424 1.7 Ensembl ENCODE dbSUPER 10.9 +58.5 58453 12.1 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TMA7 SHISA5 FBXW12 NME6 SPINK8 CDC25A RNU7-128P NDUFB1P1 TREX1 LAMB2
GH03G048464 1.4 ENCODE dbSUPER 10.5 +97.9 97914 11.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 WRNIP1 SIN3A ARID4B DMAP1 TMA7 ATRIP SHISA5 ENSG00000223343 ENSG00000244380 CCDC51 PLXNB1 COL7A1 PFKFB4 UCN2
GH03G048401 1.2 Ensembl ENCODE dbSUPER 11.6 +30.3 30296 1.7 PAF1 JUN BHLHE40 USF2 MAX MNT FOSL1 JUND POLR2A ZNF600 SHISA5 PLXNB1 FBXW12 TMA7 CCDC51 ATRIP NME6 ENSG00000244380 SPINK8 RN7SL321P
GH03G048232 1.2 Ensembl ENCODE 11 -139.5 -139484 1.0 ARID4B ZNF2 ZNF207 ZNF143 DEK REST ZNF623 ZNF518A KAT8 SMARCA4 CDC25A FBXW12 NME6 NDUFB1P1 RNU7-128P ZNF589 CAMP GC03M048234
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXW12 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXW12 Gene

Chromosome:
3
Start:
48,372,175 bp from pter
End:
48,401,259 bp from pter
Size:
29,085 bases
Orientation:
Plus strand

Genomic View for FBXW12 Gene

Genes around FBXW12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW12 Gene

Proteins for FBXW12 Gene

  • Protein details for FBXW12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6X9E4-FBW12_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 12
    Protein Accession:
    Q6X9E4
    Secondary Accessions:
    • E9PG36
    • Q494Y9
    • Q494Z0

    Protein attributes for FBXW12 Gene

    Size:
    464 amino acids
    Molecular mass:
    53056 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXW12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW12 Gene

Post-translational modifications for FBXW12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW12 Gene

No data available for DME Specific Peptides for FBXW12 Gene

Domains & Families for FBXW12 Gene

Protein Domains for FBXW12 Gene

Suggested Antigen Peptide Sequences for FBXW12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXW12: view

No data available for UniProtKB/Swiss-Prot for FBXW12 Gene

Function for FBXW12 Gene

Molecular function for FBXW12 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXW12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXW12: view
genes like me logo Genes that share phenotypes with FBXW12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW12 Gene

Localization for FBXW12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW12 gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FBXW12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXW12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXW12 Gene

Pathways & Interactions for FBXW12 Gene

genes like me logo Genes that share pathways with FBXW12: view

Interacting Proteins for FBXW12 Gene

Gene Ontology (GO) - Biological Process for FBXW12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXW12: view

No data available for SIGNOR curated interactions for FBXW12 Gene

Drugs & Compounds for FBXW12 Gene

No Compound Related Data Available

Transcripts for FBXW12 Gene

mRNA/cDNA for FBXW12 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXW12 Gene

F-box and WD repeat domain containing 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for FBXW12 Gene

GeneLoc Exon Structure for
FBXW12
ECgene alternative splicing isoforms for
FBXW12

Expression for FBXW12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXW12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW12 Gene

This gene is overexpressed in Pancreas (x18.4).

Protein differential expression in normal tissues from HIPED for FBXW12 Gene

This gene is overexpressed in Monocytes (40.0) and Adrenal (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXW12 Gene



Protein tissue co-expression partners for FBXW12 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXW12 Gene:

FBXW12

SOURCE GeneReport for Unigene cluster for FBXW12 Gene:

Hs.288793

mRNA Expression by UniProt/SwissProt for FBXW12 Gene:

Q6X9E4-FBW12_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for FBXW12 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with FBXW12: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW12 Gene

Orthologs for FBXW12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXW12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW12 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia FBXW12 34 35
  • 74.96 (n)
rat
(Rattus norvegicus)
Mammalia Fbxw12 34
  • 59.5 (n)
mouse
(Mus musculus)
Mammalia Fbxw25 35
  • 43 (a)
OneToMany
Fbxw20 35
  • 41 (a)
OneToMany
Fbxw22 35
  • 41 (a)
OneToMany
Fbxw26 35
  • 41 (a)
OneToMany
Fbxw13 35
  • 40 (a)
OneToMany
Fbxw16 35
  • 40 (a)
OneToMany
Fbxw18 35
  • 40 (a)
OneToMany
Fbxw19 35
  • 40 (a)
OneToMany
Fbxw24 35
  • 40 (a)
OneToMany
Fbxw14 35
  • 39 (a)
OneToMany
Fbxw21 35
  • 39 (a)
OneToMany
Fbxw28 35
  • 39 (a)
OneToMany
Fbxw15 35
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FBXW12 35
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXW12 35
  • 35 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXW12 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXW12 35
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FBXW12 35
  • 29 (a)
OneToOne
Species where no ortholog for FBXW12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW12 Gene

ENSEMBL:
Gene Tree for FBXW12 (if available)
TreeFam:
Gene Tree for FBXW12 (if available)

Paralogs for FBXW12 Gene

Pseudogenes.org Pseudogenes for FBXW12 Gene

genes like me logo Genes that share paralogs with FBXW12: view

No data available for Paralogs for FBXW12 Gene

Variants for FBXW12 Gene

Sequence variations from dbSNP and Humsavar for FBXW12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000033582 -- 48,380,690(+) TGCGA(C/T)GCTCT intron-variant
rs1000089258 -- 48,388,822(+) TCGGG(C/G)TAATT intron-variant
rs1000284416 -- 48,374,019(+) GAAAC(C/T)CTAAA intron-variant
rs1000284554 -- 48,372,032(+) TTTTG(A/C)GAGGA upstream-variant-2KB
rs1000378133 -- 48,394,148(+) GAGGC(C/T)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW12 Gene

Variant ID Type Subtype PubMed ID
esv3596107 CNV loss 21293372
nsv590242 CNV loss 21841781
nsv834683 CNV gain 17160897
nsv834684 CNV gain 17160897

Variation tolerance for FBXW12 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXW12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXW12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW12 Gene

Disorders for FBXW12 Gene

Relevant External Links for FBXW12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXW12

No disorders were found for FBXW12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW12 Gene

Publications for FBXW12 Gene

  1. cDNA cloning and expression analysis of a novel human F-box domain containing gene. (PMID: 15040455) Zeng L. … Mao Y. (Mol. Biol. Rep. 2004) 2 3 4 64
  2. The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor. (PMID: 26171402) Franz J. … Weathington N.M. (J Immunol Res 2015) 3 64
  3. FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer. (PMID: 26617728) De La Chesnaye E. … Ojeda S.R. (Int J Clin Exp Pathol 2015) 3 64
  4. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. (PMID: 19028597) Ebstein F. … Kloetzel P.-M. (Int. J. Biochem. Cell Biol. 2009) 3 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64

Products for FBXW12 Gene

Sources for FBXW12 Gene

Content
Loading form....