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FBXW11 Gene

protein-coding   GIFtS: 64
GCID: GC05M171288

F-Box And WD Repeat Domain Containing 11

(Previous names: F-box and WD-40 domain protein 1B, F-box and WD-40 domain...)
(Previous symbol: FBXW1B)
  Search for FBXW11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And WD Repeat Domain Containing 111 2     BTRC22 5
FBXW1B1 2 3 5     Fbw112
BTRCP22 3 5     Hos2
F-Box And WD-40 Domain Protein 111 2     Beta-Transducin Repeat-Containing Protein 22
F-Box And WD-40 Domain Protein 1B1 2     F-Box Protein Fbw1b2
Homologous To Slimb Protein2 3     F-Box/WD Repeat-Containing Protein 112
FBW1B2 3     HOS3
F-Box And WD Repeats Protein Beta-TrCP22 3     KIAA06963
F-Box/WD Repeat-Containing Protein 1B2 3     

External Ids:    HGNC: 136071   Entrez Gene: 232912   Ensembl: ENSG000000728037   OMIM: 6056515   UniProtKB: Q9UKB13   

Export aliases for FBXW11 gene to outside databases

Previous GC identifers: GC05M171270 GC05M171221 GC05M166384


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXW11 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene
contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the
presence/absence of two alternate exons. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXW11 Gene:
FBXW11 (F-box and WD repeat domain containing 11) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and protein dimerization activity. An important paralog of this gene is FBXW7.

UniProtKB/Swiss-Prot: FBW1B_HUMAN, Q9UKB1
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates
in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the
associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the
ubiquitination of IFNAR1. Targets phosphorylation-dependent degradation of beta-catenin. Involved in the
oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by
ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint.
Has an essential role in the control of the clock-dependent transcription via degradation of PER1 and
phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and
deplete BST2 from cells and antagonize its antiviral action

Gene Wiki entry for FBXW11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXW11 gene promoter:
         HFH-3   c-Fos   AP-1   FOXL1   YY1   C/EBPalpha   FOXO1a   c-Jun   En-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXW11 promoter sequence
   Search Chromatin IP Primers for FBXW11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXW11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

FBXW11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW11 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M171288:  view genomic region     (about GC identifiers)

Start:
171,288,553 bp from pter      End:
171,433,877 bp from pter
Size:
145,325 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBW1B_HUMAN, Q9UKB1 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 11  
Size: 542 amino acids; 62091 Da
Subunit: Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer.
Interacts with BTRC, BST2, PER1, RCAN1 and USP47. Interacts with phosphorylated ubiquitination substrate PER2 (By
similarity). Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction
requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S.
Interacts with TRIM21
Sequence caution: Sequence=BAA31671.1; Type=Erroneous initiation;
Secondary accessions: B2RC98 Q9P2S8 Q9P2S9 Q9Y4C6
Alternative splicing: 3 isoforms:  Q9UKB1-1   Q9UKB1-2   Q9UKB1-3   

Explore the universe of human proteins at neXtProt for FBXW11: NX_Q9UKB1

Explore proteomics data for FBXW11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys179
  • Modification sites at PhosphoSitePlus

  • See FBXW11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_036432.2  NP_387448.2  NP_387449.2  

    ENSEMBL proteins: 
     ENSP00000296933   ENSP00000265094   ENSP00000377391   ENSP00000430104   ENSP00000427777  
     ENSP00000428753   ENSP00000431100   ENSP00000429818   ENSP00000444929  
    Reactome Protein details: Q9UKB1

    FBXW11 Human Recombinant Protein Products:

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    Novus Biologicals FBXW11 Proteins
    Novus Biologicals FBXW11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXW11

     
    Search eBioscience for Proteins for FBXW11 

    FBXW11 Antibody Products:

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    Cloud-Clone Corp. ELISAs for FBXW11
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    Search eBioscience for ELISAs for FBXW11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR021977 Beta-TrCP_D
     IPR019775 WD40_repeat_CS
     IPR001810 F-box_dom
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep

    Graphical View of Domain Structure for InterPro Entry Q9UKB1

    ProtoNet protein and cluster: Q9UKB1

    UniProtKB/Swiss-Prot: FBW1B_HUMAN, Q9UKB1
    Domain: The N-terminal D domain mediates homodimerization (By similarity)
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 WD repeats


    Find genes that share domains with FBXW11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBW1B_HUMAN, Q9UKB1
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
    and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates
    in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the
    associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the
    ubiquitination of IFNAR1. Targets phosphorylation-dependent degradation of beta-catenin. Involved in the
    oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by
    ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint.
    Has an essential role in the control of the clock-dependent transcription via degradation of PER1 and
    phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and
    deplete BST2 from cells and antagonize its antiviral action
    Induction: Expression is negatively regulated by Wnt/beta-catenin pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI14532120
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with FBXW11           About GenesLikeMe


    Phenotypes:
         10 GenomeRNAi human phenotypes for FBXW11:
     Decreased Tat-dependent transc  Decreased Wnt reporter activit  Decreased p24 protein expressi  Decreased viability of wild-ty 
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel  Increased circadian period len 
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXW11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXW11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXW11

    miRNA
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    miRTarBase miRNAs that target FBXW11:
    hsa-mir-16-5p (MIRT051087), hsa-mir-148b-3p (MIRT019282), hsa-mir-450a-5p (MIRT042396)

    Block miRNA regulation of human, mouse, rat FBXW11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXW11 (see all 86):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-519a hsa-miR-1244 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidFBXW11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXW11
    Predesigned siRNA for gene silencing in human, mouse, rat FBXW11

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): FBXW11 (NM_033645)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW11
    Addgene plasmids for FBXW11 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBW1B_HUMAN, Q9UKB1: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with FBXW11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXW11 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Regulation of PLK1 Activity at G2/M Transition
    Regulation of PLK1 Activity at G2/M Transition0.77
    Mitotic G2-G2/M phases0.69
    G2/M Transition0.70
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79
    5Cell cycle Regulation of G1 S transition part 1
    Cell cycle Regulation of G1 S transition part 1 0.39
    Cell cycle Role of SCF complex in cell cycle regulation0.39


    Find genes that share SuperPaths with FBXW11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 GeneGo (Thomson Reuters) Pathways for FBXW11
        Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Proteolysis Putative ubiquitin pathway
    Cell cycle Role of SCF complex in cell cycle regulation
    Immune response MIF-JAB1 signaling

    Selected BioSystems Pathways for FBXW11 (see all 6)
        TNF-alpha/NF-kB Signaling Pathway
    mTOR signaling pathway
    PLK1 signaling events
    Canonical Wnt signaling pathway
    Hedgehog signaling events mediated by Gli proteins

    3 Reactome Pathways for FBXW11
        Antigen processing: Ubiquitination & Proteasome degradation
    Regulation of PLK1 Activity at G2/M Transition
    Activation of NF-kappaB in B cells


    Selected Kegg Pathways  (Kegg details for FBXW11) (see all 7):
        Oocyte meiosis
    Ubiquitin mediated proteolysis
    Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXW11: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXW11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXW11 (Q9UKB11, 2, 3 ENSP000002650944) via UniProtKB, MINT, STRING, and/or I2D (see all 133)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 2, 3, ENSP000002314874EBI-355189,EBI-307486 MINT-16849 I2D: score=6 STRING: ENSP00000231487
    CUL1Q136162, 3, ENSP000003268044MINT-49908 MINT-13778 I2D: score=6 STRING: ENSP00000326804
    BTRCQ9Y2972, 3, ENSP000003592064MINT-16173 I2D: score=5 STRING: ENSP00000359206
    CDC25AP303042, 3, ENSP000003037064MINT-49907 I2D: score=4 STRING: ENSP00000303706
    MDM2Q009871, 3, ENSP000004172814EBI-355189,EBI-389668 I2D: score=2 STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination IDA--
    GO:0000278mitotic cell cycle TAS--
    GO:0006470protein dephosphorylation ISS--
    GO:0007049cell cycle ----

    Find genes that share ontologies with FBXW11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXW11 (FBW1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXW11 gene (3 alternative transcripts): 
    NM_012300.2  NM_033644.2  NM_033645.2  

    Unigene Cluster for FBXW11:

    F-box and WD repeat domain containing 11
    Hs.484138  [show with all ESTs]
    Unigene Representative Sequence: NM_012300
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296933(uc011dey.1 uc003mbm.1 uc003mbl.1 uc003mbn.1)
    ENST00000265094 ENST00000393802 ENST00000523843 ENST00000518106 ENST00000522376
    ENST00000522891 ENST00000519693 ENST00000517395 ENST00000520376 ENST00000518752
    ENST00000522507 ENST00000425623
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FBXW11 (see all 86):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-519a hsa-miR-1244 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidFBXW11 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): FBXW11 (NM_033645)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW11
    Addgene plasmids for FBXW11 
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXW11
      QuantiFast Probe-based Assays in human, mouse, rat FBXW11

    Additional mRNA sequence: 

    AB014596.1 AB033279.1 AB033280.1 AB033281.1 AF176022.1 AK294956.1 AK314999.1 BC026213.1 

    13 DOTS entries:

    DT.445329  DT.100779611  DT.444317  DT.99961381  DT.100680183  DT.100684060  DT.95171734  DT.100692698 
    DT.100833162  DT.40255826  DT.65284313  DT.91767147  DT.91954513 

    Selected AceView cDNA sequences (see all 209):

    NM_033644 AI423662 AA421686 AI369254 AI275639 AI567220 BM542586 AA482138 
    AB033279 AA889994 AW291572 AA705250 AA485949 AL040744 BI088274 BC026213 
    AW515834 NM_012300 CB178697 AB014596 AW270924 AF176022 AI092703 BM548877 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXW11 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                -     -                       -                                                                                       
    SP2:                                -           -                 -                                                                                       
    SP3:                                -     -     -                 -                                                                                       
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for FBXW11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXW11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCTTTGT
    FBXW11 Expression
    About this image


    FBXW11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Limb (Muscoskeletal System)
             Limb Bud
    FBXW11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXW11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484138
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXW11: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXW11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw111 , 5 F-box and WD-40 domain protein 111, 5 92.31(n)1
    99.63(a)1
      11 (19.02 cM)5
    1035831  NM_134015.31  NP_598776.11 
     326427245 
    chicken
    (Gallus gallus)
    Aves FBXW111 F-box and WD repeat domain containing 11 84.97(n)
    96.21(a)
      416181  NM_001039262.1  NP_001034351.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXW116
    F-box and WD repeat domain containing 11
    99(a)
    1 ↔ 1
    1(130846527-130884848)
    zebrafish
    (Danio rerio)
    Actinopterygii fbxw1b2 F-box and WD-40 domain protein 1B 77.83(n)   334373  BC045356.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta slmb6
    supernumerary limbs
    76(a)
    1 → many
    3R(16944974-16953207)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-231 lin-23 61.57(n)
    68.12(a)
      174058  NM_062884.5  NP_495285.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MET306
    F-box protein containing five copies of the WD40 m...
    22(a)
    1 → many
    IX(268651-270573) YIL046W


    ENSEMBL Gene Tree for FBXW11 (if available)
    TreeFam Gene Tree for FBXW11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXW11 gene
    FBXW72  TRAF72  BTRC2  FBXW22  WDR862  ZNF1062  
    6 SIMAP similar genes for FBXW11 using alignment to 5 protein entries:     FBW1B_HUMAN (see all proteins):
    DKFZp781N011    BTRC    WSB1    FBXW7    POC1B    WDR83

    Find genes that share paralogs with FBXW11           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FBXW11
    PGOHUM00000244107 PGOHUM00000239065


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXW11 (see all 2538)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs586533671,2
    C--171289436(+) GCCCAG/-GGGCC 3 -- ut311Minor allele frequency- -:0.00NA 2
    rs113490451,2
    C--171298350(+) CGCCC-/CAGGCA 3 -- int10--------
    rs2013006931,2
    C--171306543(+) GGCTGG/TACTAT 3 -- int10--------
    rs346635501,2
    C--171309711(+) TTTTTT/-ACTGA 3 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs767507301,2
    C--171311087(+) TTTGC-/TTTTGG 3 -- int10--------
    rs1119915341,2
    C,F--171313400(+) GAAGGG/AGAACA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs58732901,2
    C--171317492(+) AAAAAA/-CTCTC 3 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs114517621,2
    C--171321032(+) GCTCTC/-CCGCT 3 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs105584581,2
    C--171321693(+) AGGTC-/TTTTTTT 3 -- int12Minor allele frequency- TT:0.00NA CSA 4
    rs672367161,2
    C--171326703(-) TTTGAA/-TGGGA 3 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for FBXW11 (171288553 - 171433877 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FBXW11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv328032CNV Loss16902084

    Human Gene Mutation Database (HGMD): FBXW11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXW11
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXW11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605651    OMIM disorders: --


    Find genes that share disorders with FBXW11           About GenesLikeMe

    Genetic Association Database (GAD): FBXW11
    Human Genome Epidemiology (HuGE) Navigator: FBXW11 (1 document)

    Export disorders for FBXW11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXW11 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with FBXW11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1. (PubMed id 10694485)1, 2, 3 Koike J....Katoh M. (Biochem. Biophys. Res. Commun. 2000)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    3. HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. (PubMed id 10321728)1, 2, 9 Fuchs S.Y.... Ronai Z. (Oncogene 1999)
    4. The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. (PubMed id 19966869)1, 2 Peschiaroli A.... Melino G. (Oncogene 2010)
    5. Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta- TrCP ubiquitin ligase. (PubMed id 18575781)1, 2 Asada S.... Kishi T. (Int. J. Mol. Med. 2008)
    6. Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. (PubMed id 16880511)1, 2 Sabile A....Krek W. (Mol. Cell. Biol. 2006)
    7. SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. (PubMed id 15917222)1, 2 Shirogane T.... Harper J.W. (J. Biol. Chem. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. (PubMed id 14603323)1, 2 Busino L.... Draetta G.F. (Nature 2003)
    10. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. (PubMed id 14532120)1, 2 Kumar K.G....Fuchs S.Y. (EMBO J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23291 HGNC: 13607 AceView: FBXW11 Ensembl:ENSG00000072803 euGenes: HUgn23291
    ECgene: FBXW11 Kegg: 23291 H-InvDB: FBXW11

    (According to HUGE)
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    HUGE: KIAA0696

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXW11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXW11 gene:
    Search GeneIP for patents involving FBXW11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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