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Aliases for FBXW11 Gene

Aliases for FBXW11 Gene

  • F-Box And WD Repeat Domain Containing 11 2 3 5
  • F-Box And WD Repeats Protein Beta-TrCP2 3 4
  • F-Box/WD Repeat-Containing Protein 1B 3 4
  • F-Box And WD-40 Domain Protein 1B 2 3
  • F-Box And WD-40 Domain Protein 11 2 3
  • Homologous To Slimb Protein 3 4
  • FBXW1B 3 4
  • BTRCP2 3 4
  • FBW1B 3 4
  • Hos 3 4
  • Beta-Transducin Repeat-Containing Protein 2 3
  • F-Box Protein Fbw1b 3
  • KIAA0696 4
  • BTRC2 3
  • Fbw11 3

External Ids for FBXW11 Gene

Previous HGNC Symbols for FBXW11 Gene

  • FBXW1B

Previous GeneCards Identifiers for FBXW11 Gene

  • GC05M171270
  • GC05M171221
  • GC05M166384
  • GC05M171288

Summaries for FBXW11 Gene

Entrez Gene Summary for FBXW11 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW11 Gene

FBXW11 (F-Box And WD Repeat Domain Containing 11) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and protein dimerization activity. An important paralog of this gene is TRAF7.

UniProtKB/Swiss-Prot for FBXW11 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Gene Wiki entry for FBXW11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW11 Gene

Genomics for FBXW11 Gene

Regulatory Elements for FBXW11 Gene

Promoters for FBXW11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXW11 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXW11 Gene

Chromosome:
5
Start:
171,861,549 bp from pter
End:
172,006,873 bp from pter
Size:
145,325 bases
Orientation:
Minus strand

Genomic View for FBXW11 Gene

Genes around FBXW11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW11 Gene

Proteins for FBXW11 Gene

  • Protein details for FBXW11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKB1-FBW1B_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 11
    Protein Accession:
    Q9UKB1
    Secondary Accessions:
    • B2RC98
    • Q9P2S8
    • Q9P2S9
    • Q9Y4C6

    Protein attributes for FBXW11 Gene

    Size:
    542 amino acids
    Molecular mass:
    62091 Da
    Quaternary structure:
    • Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer. Interacts with BTRC, BST2, PER1, RCAN1 and USP47. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1, PER1 and PER2; the interaction requires the phosphorylation of the two serine residues in the substrates destruction motif D-S-G-X(2,3,4)-S. Interacts with TRIM21. Interacts with PER3. Interacts with phosphorylated ubiquitination substrate CEP68 (PubMed:25503564).
    SequenceCaution:
    • Sequence=BAA31671.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW11 Gene

Proteomics data for FBXW11 Gene at MOPED

Post-translational modifications for FBXW11 Gene

  • Ubiquitination at Lys 179
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FBXW11 Gene

Domains & Families for FBXW11 Gene

Suggested Antigen Peptide Sequences for FBXW11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKB1

UniProtKB/Swiss-Prot:

FBW1B_HUMAN :
  • The N-terminal D domain mediates homodimerization.
  • Contains 7 WD repeats.
Domain:
  • The N-terminal D domain mediates homodimerization.
  • Contains 1 F-box domain.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FBXW11: view

Function for FBXW11 Gene

Molecular function for FBXW11 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
UniProtKB/Swiss-Prot Induction:
Expression is negatively regulated by Wnt/beta-catenin pathway.
genes like me logo Genes that share phenotypes with FBXW11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXW11 Gene

Localization for FBXW11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXW11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXW11 Gene COMPARTMENTS Subcellular localization image for FBXW11 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXW11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 16880511
genes like me logo Genes that share ontologies with FBXW11: view

Pathways & Interactions for FBXW11 Gene

SuperPathways for FBXW11 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 CDK-mediated phosphorylation and removal of Cdc6
3 Cell cycle Role of SCF complex in cell cycle regulation
4 Immune System
5 Interleukin-3, 5 and GM-CSF signaling
genes like me logo Genes that share pathways with FBXW11: view

SIGNOR curated interactions for FBXW11 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for FBXW11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination IDA,TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FBXW11: view

Drugs & Compounds for FBXW11 Gene

No Compound Related Data Available

Transcripts for FBXW11 Gene

Unigene Clusters for FBXW11 Gene

F-box and WD repeat domain containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: - - -

Relevant External Links for FBXW11 Gene

GeneLoc Exon Structure for
FBXW11
ECgene alternative splicing isoforms for
FBXW11

Expression for FBXW11 Gene

mRNA expression in normal human tissues for FBXW11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXW11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.6), Retina (21.0), and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXW11 Gene



SOURCE GeneReport for Unigene cluster for FBXW11 Gene Hs.484138

genes like me logo Genes that share expression patterns with FBXW11: view

Protein tissue co-expression partners for FBXW11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXW11 Gene

Orthologs for FBXW11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW11 36
  • 100 (a)
OneToOne
FBXW11 35
  • 99.63 (n)
  • 99.82 (a)
cow
(Bos Taurus)
Mammalia FBXW11 36
  • 94 (a)
OneToOne
FBXW11 35
  • 93.23 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia FBXW11 36
  • 100 (a)
OneToOne
FBXW11 35
  • 96.49 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Fbxw11 16
Fbxw11 36
  • 96 (a)
OneToOne
Fbxw11 35
  • 92.31 (n)
  • 99.63 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXW11 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXW11 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXW11 36
  • 95 (a)
OneToOne
FBXW11 35
  • 84.97 (n)
  • 96.21 (a)
lizard
(Anolis carolinensis)
Reptilia FBXW11 36
  • 99 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fbxw1b 35
fbxw11b 35
  • 75.98 (n)
  • 92.71 (a)
fbxw11b 36
  • 88 (a)
OneToMany
fbxw11a 36
  • 87 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta slmb 36
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-23 36
  • 47 (a)
OneToMany
lin-23 35
  • 61.57 (n)
  • 68.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET30 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8954 36
  • 63 (a)
OneToMany
Species with no ortholog for FBXW11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FBXW11 Gene

ENSEMBL:
Gene Tree for FBXW11 (if available)
TreeFam:
Gene Tree for FBXW11 (if available)

Paralogs for FBXW11 Gene

Paralogs for FBXW11 Gene

(6) SIMAP similar genes for FBXW11 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FBXW11 Gene

genes like me logo Genes that share paralogs with FBXW11: view

Variants for FBXW11 Gene

Sequence variations from dbSNP and Humsavar for FBXW11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs861429 -- 171,886,381(-) gtcca(A/G)gtgtt intron-variant
rs863401 -- 171,902,427(+) TAAAC(C/T)CCATT intron-variant
rs1098019 -- 171,922,098(-) Cccct(C/G)cctcc intron-variant
rs702110 -- 171,861,351(-) TGAAC(C/T)TCAGG downstream-variant-500B
rs702111 -- 171,905,601(+) CCCCT(C/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW11 Gene

Variant ID Type Subtype PubMed ID
nsv328032 CNV Loss 16902084

Variation tolerance for FBXW11 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXW11 Gene

HapMap Linkage Disequilibrium report
FBXW11
Human Gene Mutation Database (HGMD)
FBXW11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW11 Gene

Disorders for FBXW11 Gene

Relevant External Links for FBXW11

Genetic Association Database (GAD)
FBXW11
Human Genome Epidemiology (HuGE) Navigator
FBXW11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXW11

No disorders were found for FBXW11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW11 Gene

Publications for FBXW11 Gene

  1. Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1. (PMID: 10694485) Koike J. … Katoh M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 67
  2. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (PMID: 15070733) Watanabe N. … Osada H. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  3. HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. (PMID: 10321728) Fuchs S.Y. … Ronai Z. (Oncogene 1999) 3 23
  4. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3
  5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3

Products for FBXW11 Gene

Sources for FBXW11 Gene

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