FBXW11 Gene
protein-coding GIFtS: 61
GCID: GC05M171288
|
|
F-box and WD repeat domain containing 11(Previous names: F-box and WD-40 domain protein 1B, F-box and WD-40 domain...)
(Previous symbol: FBXW1B)
| |
Aliases
for FBXW11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And WD Repeat Domain Containing 111 2 | | Homologous To Slimb Protein2 3 | | BTRCP21 2 3 5 | | FBW1B2 3 | | FBXW1B1 2 3 5 | | F-Box And WD Repeats Protein Beta-TrCP22 3 | | BTRC21 2 5 | | F-Box/WD Repeat-Containing Protein 1B2 3 | | Fbw111 2 | | Fbw1b1 | | Hos1 2 | | Beta-Transducin Repeat-Containing Protein 22 | | F-Box And WD-40 Domain Protein 111 2 | | F-Box Protein Fbw1b2 | | F-Box And WD-40 Domain Protein 1B1 2 | | F-Box/WD Repeat-Containing Protein 112 | | KIAA06961 3 | | HOS3 |
Export aliases for FBXW11 gene to outside databasesPrevious GC identifers: GC05M171270 GC05M171221 GC05M166384 |
Summaries
for FBXW11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXW11:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbwsclass and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and itsalternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FBW1B_HUMAN, Q9UKB1Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and bindsto phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates in Wntsignaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associatedNFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination ofIFNAR1. Targets phosphorylation-dependent degradation of beta-catenin. Involved in the oxidative stress-induced aubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cellsprogressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in thecontrol of the clock-dependent transcription via degradation of PER1 and phosphorylated PER2. Is target of humanimmunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize itsantiviral action
Gene Wiki entry for FBXW11
|
Genomic Views
for FBXW11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXW11 gene promoter:
HFH-3 c-Fos AP-1 FOXL1 YY1 C/EBPalpha FOXO1a c-Jun En-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXW11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.1 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35.1FBXW11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M171288: view genomic region
(about GC identifiers)
Start:
|
171,288,553 bp from pter |
End:
|
171,433,877 bp from pter |
Size:
|
145,325 bases |
Orientation:
|
minus strand |
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Proteins
for FBXW11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBW1B_HUMAN, Q9UKB1 (See
protein sequence)Recommended Name: F-box/WD repeat-containing protein 11 Size: 542 amino acids; 62091 Da
Subunit: Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer. Interactswith BTRC, BST2, PER1, RCAN1 and USP47. Interacts with phosphorylated ubiquitination substrate PER2 (By similarity).Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction requires thephosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. Interacts withTRIM21
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=BAA31671.1; Type=Erroneous initiation;
Secondary accessions: B2RC98 Q9P2S8 Q9P2S9 Q9Y4C6Alternative splicing: 3 isoforms: Q9UKB1-1 Q9UKB1-2 Q9UKB1-3 Explore the universe of human proteins at neXtProt for FBXW11: NX_Q9UKB1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKB1
FBXW11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_036432.2 NP_387448.2 NP_387449.2
ENSEMBL proteins: ENSP00000296933 ENSP00000265094 ENSP00000377391 ENSP00000430104 ENSP00000427777 ENSP00000428753 ENSP00000431100 ENSP00000429818 ENSP00000444929 Reactome Protein details: Q9UKB1
Human Recombinant Protein Products for FBXW11:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
FBXW11 for ontologies About GeneDecksing
FBXW11 Antibody Products:
Assay Products for FBXW11: |
Protein
Domains /
Families
for FBXW11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXW11 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9UKB1ProtoNet protein and cluster: Q9UKB1 UniProtKB/Swiss-Prot: FBW1B_HUMAN, Q9UKB1Domain: The N-terminal D domain mediates homodimerization (By similarity)Similarity: Contains 1 F-box domainSimilarity: Contains 7 WD repeats |
Function
for FBXW11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FBW1B_HUMAN, Q9UKB1Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and bindsto phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates in Wntsignaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associatedNFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination ofIFNAR1. Targets phosphorylation-dependent degradation of beta-catenin. Involved in the oxidative stress-induced aubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cellsprogressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in thecontrol of the clock-dependent transcription via degradation of PER1 and phosphorylated PER2. Is target of humanimmunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize itsantiviral actionInduction: Expression is negatively regulated by Wnt/beta-catenin pathway Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FBXW11 for ontologies About GeneDecksing
Phenotypes:
10 GenomeRNAi human phenotypes for FBXW11:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW11 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW11 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FBXW11 (NM_033645) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW11 |
|
Pathways & Interactions
for FBXW11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Cell cycle_Role of SCF complex in cell cycle regulation | | | 3 | Immune response_MIF-JAB1 signaling | | | 4 | Immune System | | | 5 | Signaling by the B Cell Receptor (BCR) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for FBXW11
5  GeneGo (Thomson Reuters) Pathways for FBXW11
5/6  BioSystems Pathways for FBXW11 (see all 6)
5/9 
Reactome Pathways for FBXW11 (see all 9)
5/6 
Kegg Pathways (Kegg details for FBXW11) (see all 6):
FBXW11 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXW11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/96 Interacting proteins for FBXW11 (Q9UKB11, 2, 3 ENSP000002650944) via UniProtKB, MINT, STRING, and/or I2D (see all 96)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SKP1 | P632081, 2, 3, ENSP000002314874 | EBI-355189,EBI-307486 MINT-16849 I2D:
score=6 STRING: ENSP00000231487 | | CUL1 | Q136162, 3, ENSP000003268044 | MINT-49908 MINT-13778 I2D:
score=6 STRING: ENSP00000326804 | | BTRC | Q9Y2972, 3, ENSP000003592064 | MINT-16173 I2D:
score=5 STRING: ENSP00000359206 | | CDC25A | P303042, 3, ENSP000003037064 | MINT-49907 I2D:
score=4 STRING: ENSP00000303706 | | MDM2 | Q009871, 3, ENSP000004172814 | EBI-355189,EBI-389668 I2D:
score=2 STRING: ENSP00000417281 |
About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
FBXW11 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXW11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXW11
Search CenterWatch for drugs/clinical trials and news about FBXW11 / FBW1B
|
Transcripts
for FBXW11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXW11 gene (3 alternative transcripts): NM_012300.2 NM_033644.2 NM_033645.2 Unigene Cluster for FBXW11: F-box and WD repeat domain containing 11 Hs.484138 [show with all ESTs]Unigene Representative Sequence: NM_01230013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296933(uc011dey.1 uc003mbm.1 uc003mbl.1 uc003mbn.1)
ENST00000265094 ENST00000393802 ENST00000523843 ENST00000518106 ENST00000522376
ENST00000522891 ENST00000519693 ENST00000517395 ENST00000520376 ENST00000518752
ENST00000522507 ENST00000425623
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW11 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW11 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FBXW11 (NM_033645) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW11 |
Additional cDNA sequence: AB014596.1 AB033279.1 AB033280.1 AB033281.1 AF176022.1 AK294956.1 AK314999.1 BC026213.1 13 DOTS entries: DT.445329 DT.100779611 DT.444317 DT.99961381 DT.100680183 DT.100684060 DT.95171734 DT.100692698 DT.100833162 DT.40255826 DT.65284313 DT.91767147 DT.91954513 24/209 AceView cDNA sequences (see all 209): AI936301 NM_033645 NM_012300 BE302878 AL531016 BI088274 AI275639 AL040744 AL041305 BM548877 BC026213 BE644899 AA334083 AI369254 AI200411 AI092703 AI491791 AB033281 AI692187 AA723923 AA740346 AI192967 AI567220 BM542586
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW11 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXW11
|
Expression
for FBXW11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXW11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGCTTTGT
About this image
See FBXW11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXW11
SOURCE GeneReport for Unigene cluster: Hs.484138
SABiosciences Expression via Pathway-Focused PCR Arrays including FBXW11:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXW11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW11 |
Orthologs
for FBXW11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXW11 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FBXW111 |
F-box and WD repeat domain containing 11 |
84.97(n)
96.21(a) |
|
416181 NM_001039262.1 NP_001034351.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FBXW116 |
-- |
91(a) |
1 ↔ 1 |
1(130851296-130886471) |
zebrafish
(Danio rerio) |
Actinopterygii |
fbxw1b2 |
F-box and WD-40 domain protein 1B |
77.83(n) |
|
334373 BC045356.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
slmb6 |
supernumerary limbs |
76(a) |
1 → many |
3R(16944974-16953207) |
worm
(Caenorhabditis elegans) |
Secernentea |
lin-231 |
Protein LIN-23 |
61.63(n)
68.27(a) |
|
174058 NM_062884.4 NP_495285.1 |
ENSEMBL Gene Tree for FBXW11 (if available)
TreeFam Gene Tree for FBXW11 (if available) |
Paralogs
for FBXW11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXW11 gene
- FBXW72 TRAF72 BTRC2 FBXW22 ZNF1062 WDR862
6 SIMAP similar genes for FBXW11 using alignment to 5 protein entries: FBW1B_HUMAN (see all proteins):DKFZp781N011 BTRC WSB1 FBXW7 POC1B WDR83
FBXW11 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FBXW11
PGOHUM00000244107 PGOHUM00000239065
|
Genomic Variants
for FBXW11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXW11 (171288553 - 171433877 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FBXW11
1 CNV: 6466
Human Gene Mutation Database (HGMD): FBXW11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW11 |
|
Disorders
/ Diseases
for FBXW11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXW11 for disorders About GeneDecksing
OMIM gene information: 605651
OMIM disorders: --
8  diseases for FBXW11: About MalaCardsvesicoureteral reflux holoprosencephaly wilms tumor polydactyly
shigellosis immunodeficiency melanoma neuronitis
Human Genome Epidemiology (HuGE) Navigator: FBXW11 (1 document)
Export disorders for FBXW11 gene to outside databases
|
Publications
for FBXW11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXW11 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with FBXW11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1. (PubMed id 10694485)1, 2, 3 Koike J....Katoh M. (2000)
- Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
- HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. (PubMed id 10321728)1, 2, 9 Fuchs S.Y.... Ronai Z. (1999)
- The ubiquitin-specific protease USP47 is a novel beta -TRCP interactor regulating cell survival. (PubMed id 19966869)1, 2 Peschiaroli A....Melino G. (2010)
- Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase. (PubMed id 18575781)1, 2 Asada S....Kishi T. (2008)
- Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. (PubMed id 16880511)1, 2 Sabile A....Krek W. (2006)
- SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. (PubMed id 15917222)1, 2 Shirogane T....Harper J.W. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. (PubMed id 14603323)1, 2 Busino L.... Draetta G.F. (2003)
- SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. (PubMed id 14532120)1, 2 Kumar K.G....Fuchs S.Y. (2003)
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External Searches for FBXW11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing FBXW11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing FBXW11 gene
(According to HUGE)
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Specialized Databases showing FBXW11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FBXW11 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FBXW11 gene:
Search GeneIP for patents involving FBXW11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FBXW11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FBXW11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXW11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW11 | | | OriGene Protein Over-expression Lysate for FBXW11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBXW11 | | OriGene 3'-UTR Clone for FBXW11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FBXW11 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXW11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXW11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW11 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW11 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW11 |
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