Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXW10 Gene

protein-coding   GIFtS: 50
GCID: GC17P018647

F-Box And WD Repeat Domain Containing 10

(Previous names: chromosome 17 open reading frame 1A, F-box and WD-40 domain...)
(Previous symbols: C17orf1, C17orf1A)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box And WD Repeat Domain Containing 101 2     SM25H22
F-Box And WD-40 Domain Protein 101 2     SM2SH22
C17orf11     F-Box/WD Repeat-Containing Protein 102
C17orf1A1     Ubiquitin Ligase Specificity Factor2
Chromosome 17 Open Reading Frame 1A1     F-Box And WD-40 Domain-Containing Protein 103
Fbw102     Ubiquitin Ligase-Specificity Factor3
HREP2     

External Ids:    HGNC: 12111   Entrez Gene: 105172   Ensembl: ENSG000001719317   OMIM: 6116795   UniProtKB: Q5XX133   

Export aliases for FBXW10 gene to outside databases

Previous GC identifers: GC17P018589 GC17P018230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXW10 Gene:
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXW10 Gene:
FBXW10 (F-box and WD repeat domain containing 10) is a protein-coding gene. An important paralog of this gene is ENSG00000181464.

UniProtKB/Swiss-Prot: FBW10_HUMAN, Q5XX13
Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase
complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Overexpression is leading to degradation of CBX5 and CBX1

Gene Wiki entry for FBXW10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXW10 gene promoter:
         COUP-TF1   COUP-TF   COUP   FOXO1a   MyoD   HNF-4alpha2   HNF-4alpha1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXW10 promoter sequence
   Search Chromatin IP Primers for FBXW10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXW10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11

FBXW10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXW10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P018647:  view genomic region     (about GC identifiers)

Start:
18,647,326 bp from pter      End:
18,682,662 bp from pter
Size:
35,337 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBW10_HUMAN, Q5XX13 (See protein sequence)
Recommended Name: F-box/WD repeat-containing protein 10  
Size: 1052 amino acids; 119846 Da
Secondary accessions: C9JRY8 C9JZD7 Q8TC00 Q9H0F0
Alternative splicing: 4 isoforms:  Q5XX13-1   Q5XX13-2   Q5XX13-3   Q5XX13-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXW10: NX_Q5XX13

Explore proteomics data for FBXW10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXW10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254514.1  NP_001254515.1  

    ENSEMBL proteins: 
     ENSP00000379025   ENSP00000310382   ENSP00000463552   ENSP00000306937   ENSP00000379026  
    Reactome Protein details: Q5XX13

    FBXW10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FBXW10
    GenScript Custom Purified and Recombinant Proteins Services for FBXW10
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXW10

     
    Search eBioscience for Proteins for FBXW10 

    FBXW10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FBXW10
    Novus Biologicals FBXW10 Antibodies
    Abcam antibodies for FBXW10
    Cloud-Clone Corp. Antibodies for FBXW10
    ThermoFisher Antibody for FBXW10
    LSBio Antibodies in human, mouse, rat for FBXW10

    FBXW10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXW10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXW10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXW10
    Cloud-Clone Corp. CLIAs for FBXW10
    Search eBioscience for ELISAs for FBXW10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FBXW: F-boxes / WD-40 domains
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001810 F-box_dom
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q5XX13

    ProtoNet protein and cluster: Q5XX13

    UniProtKB/Swiss-Prot: FBW10_HUMAN, Q5XX13
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 WD repeats


    Find genes that share domains with FBXW10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBW10_HUMAN, Q5XX13
    Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase
    complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Overexpression is leading to degradation of CBX5 and CBX1
    Induction: By disease-causing laminin A mutants also inducing CBX5 and CBX1 proteasomal degradation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FBXW10           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FBXW10:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXW10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXW10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXW10

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FBXW10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FBXW10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXW10
    Predesigned siRNA for gene silencing in human, mouse, rat FBXW10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXW10

    Clone
    Products:
         
    OriGene clones in human, mouse for FBXW10 (see all 2)
    OriGene ORF clones in mouse, rat for FBXW10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW10 (NM_031456)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXW10
    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXW10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FBXW10 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with FBXW10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FBXW10
        Association of TriC/CCT with target proteins during biosynthesis


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXW10: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FBXW10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FBXW10 (ENSP000003790264) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC6ENSP000002097284STRING: ENSP00000209728
    PSMD8ENSP000002150714STRING: ENSP00000215071
    PSMD2ENSP000003101294STRING: ENSP00000310129
    ATP6V1AENSP000002733984STRING: ENSP00000273398
    DDI1ENSP000003028054STRING: ENSP00000302805
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXW10 (FBW10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FBXW10 gene (3 alternative transcripts): 
    NM_031456.3  NM_001267585.1  NM_001267586.1  

    Unigene Cluster for FBXW10:

    F-box and WD repeat domain containing 10
    Hs.592128  [show with all ESTs]
    Unigene Representative Sequence: NR_051988
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395665 ENST00000308799(uc002gul.3) ENST00000574478 ENST00000301938
    ENST00000573605 ENST00000395667(uc002guj.3 uc002guk.3 uc010cqh.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXW10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FBXW10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXW10
    Predesigned siRNA for gene silencing in human, mouse, rat FBXW10
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXW10 (see all 2)
    OriGene ORF clones in mouse, rat for FBXW10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXW10 (NM_031456)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXW10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXW10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXW10
      QuantiTect SYBR Green Assays in human, mouse, rat FBXW10
      QuantiFast Probe-based Assays in human, mouse, rat FBXW10

    Additional mRNA sequence: 

    AK310383.1 AL136822.1 AY729024.1 NR_051988.1 

    7 DOTS entries:

    DT.99958727  DT.100743137  DT.120937583  DT.100689099  DT.40122744  DT.40273190  DT.91647682 

    24 AceView cDNA sequences:

    BI828401 BV183779 BV183782 BG724426 BQ774415 BV174334 BV167162 BP369886 
    AL136822 BV179399 BV172996 NM_031456 BC028364 BV167161 BV167160 AV721196 
    AI809214 BI461612 BF979266 AA634374 BG721464 BF979797 BE502292 BU568777 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FBXW10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCAGGAAG
    FBXW10 Expression
    About this image

    FBXW10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXW10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592128
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXW10: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXW10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXW10
    QuantiTect SYBR Green Assays in human, mouse, rat FBXW10
    QuantiFast Probe-based Assays in human, mouse, rat FBXW10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXW10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxw101 , 5 F-box and WD-40 domain protein 101, 5 79.1(n)1
    72.46(a)1
      11 (38.78 cM)5
    2139801  NM_001033669.21  NP_001028841.21 
     628470695 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    32(a)
    1 → many
    18(2210821-2221821)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    2(106145348-106170865)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX711433.12   -- 74.72(n)    BX711433.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5639981 F-box/WD repeat-containing protein 10-like 52.79(n)
    41.63(a)
      563998  XM_687357.4  XP_692449.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP466
    Member of the NineTeen Complex (NTC) that contains...
    17(a)
    1 → many
    XVI(266180-267535) YPL151C


    ENSEMBL Gene Tree for FBXW10 (if available)
    TreeFam Gene Tree for FBXW10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FBXW10 gene
    ENSG000001814642  CDRT12  PLRG12  KATNB12  
    2 SIMAP similar genes for FBXW10 using alignment to 2 protein entries:     FBW10_HUMAN (see all proteins):
    CDRT1    GNB5

    Find genes that share paralogs with FBXW10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FBXW10 (see all 778)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs284968161,2
    --18645326(+) CTGGAA/GCTACA 3 -- us2k10--------
    rs283870121,2
    --18645328(+) GGAACC/TACAGG 3 -- us2k10--------
    rs620737431,2
    C--18646827(+) GTTGCT/CTGCTC 3 -- us2k12Minor allele frequency- C:0.25NA WA 4
    rs1833542321,2
    --18646832(+) CTGCTC/TGAGAC 3 -- us2k10--------
    rs1490117711,2
    --18646937(+) GCTGCC/TCAATA 3 -- us2k10--------
    rs1510374231,2
    C--18647096(+) AGCCAC/GTTTGT 3 -- us2k10--------
    rs1502301581,2
    C--18647463(+) CACAAC/TTGGGG 3 -- ut51 nc-transcript-variant0--------
    rs1861195181,2
    C--18647523(+) CAAGTA/G/TCGCAG 6 -- ut51 nc-transcript-variant0--------
    rs1164836571,2
    C--18647539(+) AAATGA/GACTGG 3 -- ut51 nc-transcript-variant0--------
    rs745027781,2
    C,F--18647625(+) TTCCAA/TCCCTC 5 N I mis12Minor allele frequency- T:0.41NA EU 5779

    HapMap Linkage Disequilibrium report for FBXW10 (18647326 - 18682662 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FBXW10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715725CNV Deletion23290073
    nsv833389CNV Gain17160897
    nsv523721CNV Gain19592680
    nsv907782CNV Gain21882294
    nsv9504CNV Gain+Loss18304495
    nsv499818OTHER Inversion21111241

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXW10
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXW10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611679    OMIM disorders: --


    Find genes that share disorders with FBXW10           About GenesLikeMe


    Export disorders for FBXW10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FBXW10 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with FBXW10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1, 2 Chaturvedi P. and Parnaik V.K. (PLoS ONE 2010)
    2. Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1, 2 Jin J....Harper J.W. (Genes Dev. 2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    4. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. (PubMed id 23899520)1 Feng Z....Lianwen Z. (Biochem. Biophys. Res. Commun. 2013)
    5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat. (PubMed id 9787083)3 Kennerson M.L.... Nicholson G.A. (Genomics 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10517 HGNC: 1211 AceView: FBXW10 Ensembl:ENSG00000171931 euGenes: HUgn10517
    ECgene: FBXW10 H-InvDB: FBXW10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FBXW10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FBXW10 gene:
    Search GeneIP for patents involving FBXW10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXW10  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXW10  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXW10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXW10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXW10   OriGene Custom Protein Services for FBXW10  

     
     
     Block miRNA regulation of human, mouse, rat FBXW10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXW10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXW10 Predesigned siRNA for gene silencing in human, mouse, rat FBXW10
     QuantiFast Probe-based Assays in human, mouse, rat FBXW10 QuantiTect SYBR Green Assays in human, mouse, rat FBXW10
     PCR Arrays including human, mouse, rat FBXW10 Search Chromatin IP Primers for FBXW10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXW10  GeneGlobe Interaction Network for FBXW10
     Regulatory tfbs in FBXW10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FBXW10 GenScript cDNA clones with any tag delivered in your preferred vector for FBXW10
     GenScript Custom Assay Services for FBXW10 GenScript Custom overexpressing Cell Line Services for FBXW10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FBXW10 (FBW10)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FBXW10 antibodies
     Antibodies for FBXW10
     See all of Abcam's Antibodies, Kits and Proteins for FBXW10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FBXW10
     Antibodies for FBXW10
     ELISAs for FBXW10
     CLIAs for FBXW10



     Browse ESI BIO Cell Lines and PureStem Progenitors for FBXW10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FBXW10
     SwitchGear Promoter luciferase reporter plasmids for FBXW10
     ThermoFisher Antibody for FBXW10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXW10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXW10
     LSBio Antibodies in human, mouse, rat for FBXW10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FBXW10
      Search eBioscience for proteins for FBXW10
      Search eBioscience for elisas for FBXW10
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXW10 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4