FBXW10 Gene
protein-coding GIFtS: 48
GCID: GC17P018647
|
|
F-box and WD repeat domain containing 10(Previous names: chromosome 17 open reading frame 1A, F-box and WD-40 domain...)
(Previous symbols: C17orf1, C17orf1A)
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Aliases
for FBXW10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And WD Repeat Domain Containing 101 2 | | Chromosome 17 Open Reading Frame 1A1 | | Fbw101 2 | | SM25H22 | | HREP1 2 | | F-Box/WD Repeat-Containing Protein 102 | | SM2SH21 2 | | Ubiquitin Ligase Specificity Factor2 | | F-Box And WD-40 Domain Protein 101 2 | | F-Box And WD-40 Domain-Containing Protein 103 | | C17orf11 | | Ubiquitin Ligase-Specificity Factor3 | | C17orf1A1 | | |
Export aliases for FBXW10 gene to outside databasesPrevious GC identifers: GC17P018589 GC17P018230 |
Summaries
for FBXW10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXW10:
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FBW10_HUMAN, Q5XX13Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leadingto degradation of CBX5 and CBX1
Gene Wiki entry for FBXW10
|
Genomic Views
for FBXW10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXW10 gene promoter:
COUP-TF1 COUP-TF COUP FOXO1a MyoD HNF-4alpha2 HNF-4alpha1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXW10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p12 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11FBXW10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P018647: view genomic region
(about GC identifiers)
Start:
|
18,647,326 bp from pter |
End:
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18,682,662 bp from pter |
Size:
|
35,337 bases |
Orientation:
|
plus strand |
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Proteins
for FBXW10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBW10_HUMAN, Q5XX13 (See
protein sequence)Recommended Name: F-box/WD repeat-containing protein 10 Size: 1052 amino acids; 119846 Da
Secondary accessions: C9JRY8 C9JZD7 Q8TC00 Q9H0F0Alternative splicing: 4 isoforms: Q5XX13-1 Q5XX13-2 Q5XX13-3 Q5XX13-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FBXW10: NX_Q5XX13
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5XX13
FBXW10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001254514.1 NP_001254515.1
ENSEMBL proteins: ENSP00000379025 ENSP00000310382 ENSP00000463552 ENSP00000306937 ENSP00000379026 Reactome Protein details: Q5XX13
Human Recombinant Protein Products:
FBXW10 Antibody Products:
Assay Products for FBXW10: |
Protein
Domains /
Families
for FBXW10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXW10 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5XX13ProtoNet protein and cluster: Q5XX13 UniProtKB/Swiss-Prot: FBW10_HUMAN, Q5XX13Similarity: Contains 1 F-box domainSimilarity: Contains 7 WD repeats |
Function
for FBXW10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBW10_HUMAN, Q5XX13Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leadingto degradation of CBX5 and CBX1Induction: By disease-causing laminin A mutants also inducing CBX5 and CBX1 proteasomal degradation
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW10 |
4 GenomeRNAi human phenotypes for FBXW10:
|
Pathways & Interactions
for FBXW10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chaperonin-mediated protein folding | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for FBXW10
FBXW10 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXW10
|
Drugs & Compounds
for FBXW10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXW10
Search CenterWatch for drugs/clinical trials and news about FBXW10 / FBW10
|
Transcripts
for FBXW10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXW10 gene (3 alternative transcripts): NM_031456.3 NM_001267585.1 NM_001267586.1 Unigene Cluster for FBXW10: F-box and WD repeat domain containing 10 Hs.592128 [show with all ESTs]Unigene Representative Sequence: NR_0519886 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395665 ENST00000308799(uc002gul.3) ENST00000574478 ENST00000301938
ENST00000573605 ENST00000395667(uc002guj.3 uc002guk.3 uc010cqh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXW10 (NM_031456) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW10 |
Additional cDNA sequence: AK310383.1 AL136822.1 AY729024.1 NR_051988.1 7 DOTS entries: DT.99958727 DT.100743137 DT.120937583 DT.100689099 DT.40122744 DT.40273190 DT.91647682 24 AceView cDNA sequences: BI828401 BV183782 BP369886 NM_031456 BQ774415 BC028364 BV183779 BV179399 BV172996 BV167161 BV174334 BV167160 BG724426 AL136822 BV167162 AV721196 AI809214 BF979266 BI461612 BG721464 AA634374 BF979797 BU568777 BE502292
GeneLoc Exon Structure
|
Expression
for FBXW10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXW10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCAGGAAG
About this image
See FBXW10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXW10
SOURCE GeneReport for Unigene cluster: Hs.592128
SABiosciences Expression via Pathway-Focused PCR Arrays including FBXW10:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW10
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW10 |
Orthologs
for FBXW10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FBXW10 gene from 5/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fbxw105 |
F-box and WD-40 domain protein 10 |
-- |
|
11 (38.78 cM) 62847069 |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
39(a) |
1 → many |
18(2194666-2204960) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
39(a) |
1 → many |
2(106145494-106169139) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX711433.12 |
-- |
74.72(n) |
|
BX711433.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CR752650.16 |
-- |
30(a) |
1 → many |
12(37125613-37134954) |
ENSEMBL Gene Tree for FBXW10 (if available)
TreeFam Gene Tree for FBXW10 (if available) |
Paralogs
for FBXW10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXW10 gene
- ENSG000002515372 ENSG000001814642 CDRT12
2 SIMAP similar genes for FBXW10 using alignment to 2 protein entries: FBW10_HUMAN (see all proteins):CDRT1 GNB5
FBXW10 for paralogs About GeneDecksing
|
Genomic Variants
for FBXW10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXW10 (18647326 - 18682662 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FBXW10
2 CNVs: 4993 30808 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW10 |
|
Disorders
/ Diseases
for FBXW10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXW10 for disorders About GeneDecksing
OMIM gene information: 611679
OMIM disorders: --
2  diseases for FBXW10: About MalaCardshereditary neuropathies neuropathy
Export disorders for FBXW10 gene to outside databases
|
Publications
for FBXW10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXW10 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FBXW10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1, 2 Chaturvedi P. and Parnaik V.K. (2010)
- Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1, 2 Jin J....Harper J.W. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat. (PubMed id 9787083)3 Kennerson M.L.... Nicholson G.A. (1998)
- Single test for two hereditary neuropathies, CMT1A an d HNPP. (PubMed id 7586531)3 Kennerson M.L....Nicholson G.A. (1995)
|
External Searches for FBXW10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXW10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXW10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXW10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXW10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXW10 gene:
Search GeneIP for patents involving FBXW10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXW10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | FBXW10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW10 |
|  |  |  | | | | ThermoFisher Antibody for FBXW10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW10 |
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