Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXW10 Gene

Aliases for FBXW10 Gene

  • F-Box And WD Repeat Domain Containing 10 2 3 5
  • F-Box And WD-40 Domain Protein 10 2 3
  • F-Box And WD-40 Domain-Containing Protein 10 4
  • F-Box/WD Repeat-Containing Protein 10 3
  • Chromosome 17 Open Reading Frame 1A 2
  • Ubiquitin Ligase Specificity Factor 3
  • Ubiquitin Ligase-Specificity Factor 4
  • Testicular Tissue Protein Li 69 3
  • SM25H2 3
  • SM2SH2 3
  • Fbw10 3
  • HREP 3

External Ids for FBXW10 Gene

Previous HGNC Symbols for FBXW10 Gene

  • C17orf1
  • C17orf1A

Previous GeneCards Identifiers for FBXW10 Gene

  • GC17P018589
  • GC17P018647
  • GC17P018230
  • GC17P018747

Summaries for FBXW10 Gene

Entrez Gene Summary for FBXW10 Gene

  • Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW10 Gene

FBXW10 (F-Box And WD Repeat Domain Containing 10) is a Protein Coding gene. Diseases associated with FBXW10 include Hereditary Neuropathies. Among its related pathways are Immune System and Chaperonin-mediated protein folding. An important paralog of this gene is CDRT1.

UniProtKB/Swiss-Prot for FBXW10 Gene

  • Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.

Gene Wiki entry for FBXW10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW10 Gene

Genomics for FBXW10 Gene

Regulatory Elements for FBXW10 Gene

Enhancers for FBXW10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F018744 0.9 Ensembl ENCODE 8.7 +5.5 5547 3.3 GATAD2A TFE3 SAP130 FOXA3 ZFP64 CHD7 RARA RAD51 NR2F6 KDM6A TVP23B FBXW10 SHMT1 SMCR8
GH17F018697 0.9 ENCODE 8.6 -42.2 -42237 1.1 HDAC1 ZNF133 ZNF76 ARID4B SIN3A DMAP1 ZNF2 ZBTB40 SCRT2 ZNF143 MFAP4 TVP23B TRIM16L FBXW10 ENSG00000264885 ZNF286B
GH17F018339 0.4 FANTOM5 1.8 -400.8 -400775 0.1 POLR2A FBXW10 SHMT1 GC17M018331 MIR6778
GH17F018718 0.6 ENCODE 0.3 -20.9 -20876 2.5 RFX1 TEAD4 DPF2 EBF1 ZIC2 GLIS1 SCRT2 FOS TVP23B SMCR8 ENSG00000265693 FBXW10
GH17F018751 0.4 Ensembl 0.4 +10.9 10878 0.2 SPI1 FBXW10 TVP23B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXW10 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXW10 Gene

18,740,223 bp from pter
18,779,349 bp from pter
39,127 bases
Plus strand

Genomic View for FBXW10 Gene

Genes around FBXW10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW10 Gene

Proteins for FBXW10 Gene

  • Protein details for FBXW10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/WD repeat-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • C9JRY8
    • C9JZD7
    • Q8TC00
    • Q9H0F0

    Protein attributes for FBXW10 Gene

    1052 amino acids
    Molecular mass:
    119846 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FBXW10 Gene


neXtProt entry for FBXW10 Gene

Post-translational modifications for FBXW10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXW10 Gene

Domains & Families for FBXW10 Gene

Suggested Antigen Peptide Sequences for FBXW10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 7 WD repeats.
  • Contains 1 F-box domain.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FBXW10: view

Function for FBXW10 Gene

Molecular function for FBXW10 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
UniProtKB/Swiss-Prot Induction:
By disease-causing laminin A mutants also inducing CBX5 and CBX1 proteasomal degradation.
genes like me logo Genes that share phenotypes with FBXW10: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW10 Gene

Localization for FBXW10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW10 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXW10 Gene

Pathways & Interactions for FBXW10 Gene

genes like me logo Genes that share pathways with FBXW10: view

Interacting Proteins for FBXW10 Gene

Selected Interacting proteins: Q5XX13-FBW10_HUMAN for FBXW10 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FBXW10 Gene


No data available for SIGNOR curated interactions for FBXW10 Gene

Transcripts for FBXW10 Gene

Unigene Clusters for FBXW10 Gene

F-box and WD repeat domain containing 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW10 Gene

No ASD Table

Relevant External Links for FBXW10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXW10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXW10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW10 Gene

This gene is overexpressed in Testis (x19.8).

Protein differential expression in normal tissues from HIPED for FBXW10 Gene

This gene is overexpressed in NK cells (43.8), Breast (15.1), and Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXW10 Gene

Protein tissue co-expression partners for FBXW10 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXW10 Gene:


SOURCE GeneReport for Unigene cluster for FBXW10 Gene:

genes like me logo Genes that share expression patterns with FBXW10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXW10 Gene

Orthologs for FBXW10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXW10 35
  • 98 (a)
(Canis familiaris)
Mammalia FBXW10 34
  • 83.35 (n)
-- 35
  • 76 (a)
-- 35
  • 11 (a)
(Mus musculus)
Mammalia Fbxw10 34 16 35
  • 79.1 (n)
(Rattus norvegicus)
Mammalia Fbxw10 34
  • 78.7 (n)
(Bos Taurus)
Mammalia FBXW10 34
  • 78.66 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
(Gallus gallus)
Aves -- 35
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw10 34
  • 55.41 (n)
(Danio rerio)
Actinopterygii LOC563998 34
  • 52.79 (n)
fbxw10 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP46 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2090 35
  • 8 (a)
Species where no ortholog for FBXW10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW10 Gene

Gene Tree for FBXW10 (if available)
Gene Tree for FBXW10 (if available)

Paralogs for FBXW10 Gene

(2) SIMAP similar genes for FBXW10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXW10: view

Variants for FBXW10 Gene

Sequence variations from dbSNP and Humsavar for FBXW10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10153280 -- 18,766,504(+) CCACC(C/T)GTATT intron-variant
rs1024657 -- 18,779,192(+) AAAAG(C/T)CAGCA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1026259 -- 18,778,600(+) TTAGC(A/G)CCCTG intron-variant, downstream-variant-500B, reference, missense
rs1026261 -- 18,778,850(+) TAGAG(C/T)CCAGT intron-variant, downstream-variant-500B, reference, missense
rs10580273 -- 18,749,375(+) CTACT(-/AA)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW10 Gene

Variant ID Type Subtype PubMed ID
nsv960431 CNV duplication 23825009
nsv962279 CNV duplication 23825009
nsv9504 CNV gain+loss 18304495
nsv833389 CNV gain 17160897
nsv523721 CNV gain 19592680
nsv499818 OTHER inversion 21111241
nsv1131302 CNV deletion 24896259
nsv1123098 CNV deletion 24896259
nsv1063354 CNV gain 25217958
nsv1057803 CNV loss 25217958
nsv1055999 CNV gain 25217958
dgv564e214 CNV gain 21293372

Variation tolerance for FBXW10 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.06; 97.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXW10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW10 Gene

Disorders for FBXW10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXW10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hereditary neuropathies
  • neuropathy - hereditary
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXW10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FBXW10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXW10 Gene

Publications for FBXW10 Gene

  1. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PMID: 20498703) Chaturvedi P. … Parnaik V.K. (PLoS ONE 2010) 3 4 64
  2. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. (PMID: 23899520) Feng Z. … Lianwen Z. (Biochem. Biophys. Res. Commun. 2013) 3 64

Products for FBXW10 Gene

Sources for FBXW10 Gene

Loading form....