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Aliases for FBXW10 Gene

Aliases for FBXW10 Gene

  • F-Box And WD Repeat Domain Containing 10 2 3
  • F-Box And WD-40 Domain Protein 10 2 3
  • F-Box And WD-40 Domain-Containing Protein 10 4
  • Chromosome 17 Open Reading Frame 1A 2
  • Ubiquitin Ligase Specificity Factor 3
  • Ubiquitin Ligase-Specificity Factor 4
  • SM25H2 3
  • SM2SH2 3
  • Fbw10 3
  • HREP 3

External Ids for FBXW10 Gene

Previous HGNC Symbols for FBXW10 Gene

  • C17orf1
  • C17orf1A

Previous GeneCards Identifiers for FBXW10 Gene

  • GC17P018589
  • GC17P018647
  • GC17P018230
  • GC17P018747

Summaries for FBXW10 Gene

Entrez Gene Summary for FBXW10 Gene

  • Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW10 Gene

FBXW10 (F-Box And WD Repeat Domain Containing 10) is a Protein Coding gene. Diseases associated with FBXW10 include hereditary neuropathies. Among its related pathways are Transport to the Golgi and subsequent modification and Protein folding. An important paralog of this gene is PLRG1.

UniProtKB/Swiss-Prot for FBXW10 Gene

  • Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.

Gene Wiki entry for FBXW10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW10 Gene

Genomics for FBXW10 Gene

Regulatory Elements for FBXW10 Gene

Genomic Location for FBXW10 Gene

Chromosome:
17
Start:
18,740,223 bp from pter
End:
18,779,349 bp from pter
Size:
39,127 bases
Orientation:
Plus strand

Genomic View for FBXW10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXW10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW10 Gene

Proteins for FBXW10 Gene

  • Protein details for FBXW10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XX13-FBW10_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 10
    Protein Accession:
    Q5XX13
    Secondary Accessions:
    • C9JRY8
    • C9JZD7
    • Q8TC00
    • Q9H0F0

    Protein attributes for FBXW10 Gene

    Size:
    1052 amino acids
    Molecular mass:
    119846 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FBXW10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW10 Gene

Proteomics data for FBXW10 Gene at MOPED

Post-translational modifications for FBXW10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW10 Gene

No data available for DME Specific Peptides for FBXW10 Gene

Domains & Families for FBXW10 Gene

Suggested Antigen Peptide Sequences for FBXW10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XX13

UniProtKB/Swiss-Prot:

FBW10_HUMAN :
  • Contains 1 F-box domain.
  • Contains 7 WD repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FBXW10: view

Function for FBXW10 Gene

Molecular function for FBXW10 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
UniProtKB/Swiss-Prot Induction:
By disease-causing laminin A mutants also inducing CBX5 and CBX1 proteasomal degradation.

Gene Ontology (GO) - Molecular Function for FBXW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXW10: view
genes like me logo Genes that share phenotypes with FBXW10: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXW10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW10 Gene

Localization for FBXW10 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FBXW10 Gene

Pathways & Interactions for FBXW10 Gene

genes like me logo Genes that share pathways with FBXW10: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for FBXW10 Gene

Gene Ontology (GO) - Biological Process for FBXW10 Gene

None

No data available for SIGNOR curated interactions for FBXW10 Gene

Drugs & Compounds for FBXW10 Gene

No Compound Related Data Available

Transcripts for FBXW10 Gene

Unigene Clusters for FBXW10 Gene

F-box and WD repeat domain containing 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXW10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW10 Gene

No ASD Table

Relevant External Links for FBXW10 Gene

GeneLoc Exon Structure for
FBXW10
ECgene alternative splicing isoforms for
FBXW10

Expression for FBXW10 Gene

mRNA expression in normal human tissues for FBXW10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW10 Gene

This gene is overexpressed in Testis (x19.8).

Protein differential expression in normal tissues from HIPED for FBXW10 Gene

This gene is overexpressed in NK cells (43.8), Breast (15.1), and Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXW10 Gene



SOURCE GeneReport for Unigene cluster for FBXW10 Gene Hs.592128

genes like me logo Genes that share expression patterns with FBXW10: view

Protein tissue co-expression partners for FBXW10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FBXW10 Gene

Orthologs for FBXW10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXW10 35
  • 78.66 (n)
  • 73.28 (a)
dog
(Canis familiaris)
Mammalia FBXW10 35
  • 83.35 (n)
  • 77.93 (a)
-- 36
  • 11 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fbxw10 35
  • 79.1 (n)
  • 72.46 (a)
Fbxw10 16
Fbxw10 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxw10 35
  • 78.7 (n)
  • 72.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FBXW10 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw10 35
  • 55.41 (n)
  • 46.03 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563998 35
  • 52.79 (n)
  • 41.63 (a)
fbxw10 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP46 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2090 36
  • 8 (a)
OneToMany
Species with no ortholog for FBXW10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW10 Gene

ENSEMBL:
Gene Tree for FBXW10 (if available)
TreeFam:
Gene Tree for FBXW10 (if available)

Paralogs for FBXW10 Gene

Paralogs for FBXW10 Gene

(2) SIMAP similar genes for FBXW10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXW10: view

Variants for FBXW10 Gene

Sequence variations from dbSNP and Humsavar for FBXW10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs960608 -- 18,756,650(+) TGTAA(C/T)CCAGC intron-variant
rs1026259 - 18,778,600(+) TTAGC(A/G)CCCTG missense, reference, intron-variant, downstream-variant-500B
rs1318979 -- 18,779,086(+) TGAAC(A/G)CTGAG reference, missense, nc-transcript-variant
rs2123375 -- 18,741,366(-) GACTC(A/G)GGAAA intron-variant
rs2323786 -- 18,741,087(-) ACACT(G/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW10 Gene

Variant ID Type Subtype PubMed ID
nsv9504 CNV Gain+Loss 18304495
nsv907782 CNV Gain 21882294
nsv499818 OTHER Inversion 21111241
nsv833389 CNV Gain 17160897
nsv523721 CNV Gain 19592680
esv2715725 CNV Deletion 23290073

Variation tolerance for FBXW10 Gene

Residual Variation Intolerance Score: 96.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.06; 97.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXW10 Gene

HapMap Linkage Disequilibrium report
FBXW10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW10 Gene

Disorders for FBXW10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXW10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hereditary neuropathies
  • neuropathy - hereditary
- elite association

Relevant External Links for FBXW10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXW10
genes like me logo Genes that share disorders with FBXW10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXW10 Gene

Publications for FBXW10 Gene

  1. Negative regulation of axis formation and Wnt signaling in Xenopus embryos by the F-box/WD40 protein beta TrCP. (PMID: 10096067) Lagna G. … Hemmati-Brivanlou A. (Mech. Dev. 1999) 23 67
  2. Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat. (PMID: 9787083) Kennerson M.L. … Nicholson G.A. (Genomics 1998) 2 67
  3. Single test for two hereditary neuropathies, CMT1A and HNPP. (PMID: 7586531) Kennerson M.L. … Nicholson G.A. (Clin. Chem. 1995) 2 67
  4. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. (PMID: 23899520) Feng Z. … Lianwen Z. (Biochem. Biophys. Res. Commun. 2013) 67
  5. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PMID: 20498703) Chaturvedi P. … Parnaik V.K. (PLoS ONE 2010) 67

Products for FBXW10 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FBXW10
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FBXW10
    • Block miRNA regulation of FBXW10 using miScript Target Protectors

    Sources for FBXW10 Gene

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