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Aliases for FBXW10 Gene

Aliases for FBXW10 Gene

  • F-Box And WD Repeat Domain Containing 10 2 3
  • F-Box And WD-40 Domain Protein 10 2 3
  • F-Box And WD-40 Domain-Containing Protein 10 4
  • F-Box/WD Repeat-Containing Protein 10 3
  • Chromosome 17 Open Reading Frame 1A 2
  • Ubiquitin Ligase Specificity Factor 3
  • Ubiquitin Ligase-Specificity Factor 4
  • SM25H2 3
  • SM2SH2 3
  • Fbw10 3
  • HREP 3

External Ids for FBXW10 Gene

Previous Symbols for FBXW10 Gene

  • C17orf1
  • C17orf1A

Summaries for FBXW10 Gene

Entrez Gene Summary for FBXW10 Gene

  • Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW10 Gene

FBXW10 (F-Box And WD Repeat Domain Containing 10) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. An important paralog of this gene is PLRG1.

UniProtKB/Swiss-Prot for FBXW10 Gene

  • Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.

Gene Wiki entry for FBXW10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXW10 Gene

Genomics for FBXW10 Gene

Genomic Location for FBXW10 Gene

Start:
18,744,013 bp from pter
End:
18,779,349 bp from pter
Size:
35,337 bases
Orientation:
Plus strand

Genomic View for FBXW10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXW10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW10 Gene

Regulatory Elements for FBXW10 Gene

Proteins for FBXW10 Gene

  • Protein details for FBXW10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XX13-FBW10_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 10
    Protein Accession:
    Q5XX13
    Secondary Accessions:
    • C9JRY8
    • C9JZD7
    • Q8TC00
    • Q9H0F0

    Protein attributes for FBXW10 Gene

    Size:
    1052 amino acids
    Molecular mass:
    119846 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FBXW10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW10 Gene

Proteomics data for FBXW10 Gene at MOPED

Post-translational modifications for FBXW10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXW10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXW10 Gene

Domains for FBXW10 Gene

Gene Families for FBXW10 Gene

HGNC:
  • WDR :WD repeat domain containing
  • FBXW :F-boxes / WD-40 domains

UniProtKB/Swiss-Prot:

FBW10_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q5XX13
Similarity:
  • Contains 7 WD repeats.:
    • Q5XX13
genes like me logo Genes that share domains with FBXW10: view

Function for FBXW10 Gene

Molecular function for FBXW10 Gene

UniProtKB/Swiss-Prot Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
UniProtKB/Swiss-Prot Induction: By disease-causing laminin A mutants also inducing CBX5 and CBX1 proteasomal degradation.

Gene Ontology (GO) - Molecular Function for FBXW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXW10: view
genes like me logo Genes that share phenotypes with FBXW10: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXW10 Gene

Localization for FBXW10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXW10 Gene COMPARTMENTS Subcellular localization image for FBXW10 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FBXW10 Gene

Pathways for FBXW10 Gene

genes like me logo Genes that share pathways with FBXW10: view

Interacting Proteins for FBXW10 Gene

Gene Ontology (GO) - Biological Process for FBXW10 Gene

None

Transcripts for FBXW10 Gene

Unigene Clusters for FBXW10 Gene

F-box and WD repeat domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW10 Gene

No ASD Table

Relevant External Links for FBXW10 Gene

GeneLoc Exon Structure for
FBXW10
ECgene alternative splicing isoforms for
FBXW10

Expression for FBXW10 Gene

mRNA expression in normal human tissues for FBXW10 Gene

mRNA differential expression in normal tissues according to GTEx for FBXW10 Gene

This gene is overexpressed in Testis (19.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FBXW10 Gene

SOURCE GeneReport for Unigene cluster for FBXW10 Gene Hs.592128

genes like me logo Genes that share expressions with FBXW10: view

Orthologs for FBXW10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW10 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXW10 36
  • 78.66 (n)
  • 73.28 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 11 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
FBXW10 36
  • 83.35 (n)
  • 77.93 (a)
mouse
(Mus musculus)
Mammalia Fbxw10 36
  • 79.1 (n)
  • 72.46 (a)
Fbxw10 16
Fbxw10 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxw10 36
  • 78.7 (n)
  • 72.52 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxw10 36
  • 55.41 (n)
  • 46.03 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxw10 37
  • 26 (a)
OneToMany
LOC563998 36
  • 52.79 (n)
  • 41.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP46 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2090 37
  • 8 (a)
OneToMany
Species with no ortholog for FBXW10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXW10 Gene

ENSEMBL:
Gene Tree for FBXW10 (if available)
TreeFam:
Gene Tree for FBXW10 (if available)

Paralogs for FBXW10 Gene

Paralogs for FBXW10 Gene

Selected SIMAP similar genes for FBXW10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXW10: view

Variants for FBXW10 Gene

Sequence variations from dbSNP and Humsavar for FBXW10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs960608 -- 18,756,650(+) TGTAA(C/T)CCAGC intron-variant
rs1318979 -- 18,779,086(+) TGAAC(A/G)CTGAG reference, missense, nc-transcript-variant
rs3032059 -- 18,761,962(-) aaaag(A/T)aaaag intron-variant
rs3826384 -- 18,756,277(-) GTTTA(A/G)GGCTG intron-variant
rs4244595 -- 18,774,016(+) AGATC(A/G)GCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXW10 Gene

Variant ID Type Subtype PubMed ID
nsv9504 CNV Gain+Loss 18304495
nsv907782 CNV Gain 21882294
nsv499818 OTHER Inversion 21111241
nsv833389 CNV Gain 17160897
nsv523721 CNV Gain 19592680
esv2715725 CNV Deletion 23290073

Relevant External Links for FBXW10 Gene

HapMap Linkage Disequilibrium report
FBXW10

Disorders for FBXW10 Gene

No disorders were found for FBXW10 Gene.

No data available for UniProtKB/Swiss-Prot for FBXW10 Gene

Publications for FBXW10 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4
  3. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PMID: 20498703) Chaturvedi P. … Parnaik V.K. (PLoS ONE 2010) 3 4
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. (PMID: 23899520) Feng Z. … Lianwen Z. (Biochem. Biophys. Res. Commun. 2013) 3

Products for FBXW10 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FBXW10
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FBXW10
    • Block miRNA regulation of FBXW10 using miScript Target Protectors
    • antibodies-online peptides for FBXW10
    • antibodies-online antibodies for FBXW10
    • antibodies-online kits for FBXW10

    Sources for FBXW10 Gene

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