Aliases for FBXW10 Gene
External Ids for FBXW10 Gene
Previous HGNC Symbols for FBXW10 Gene
Previous GeneCards Identifiers for FBXW10 Gene
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXW10 Gene
FBXW10 (F-Box And WD Repeat Domain Containing 10) is a Protein Coding gene. Diseases associated with FBXW10 include Hereditary Neuropathies. Among its related pathways are Chaperonin-mediated protein folding and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CDRT1.
UniProtKB/Swiss-Prot for FBXW10 Gene
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.