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FBXO9 Gene

protein-coding   GIFtS: 51
GCID: GC06P052916

F-Box Protein 9

(Previous name: F-box only protein 9)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 91 2     VCIA12 3
FBX92 3 5     NY-REN-572
F-Box Only Protein 91 2     dJ341E18.22
Cross-Immune Reaction Antigen 12 3     F-Box Protein Fbx92
Renal Carcinoma Antigen NY-REN-572 3     

External Ids:    HGNC: 135881   Entrez Gene: 262682   Ensembl: ENSG000001121467   OMIM: 6090915   UniProtKB: Q9UK973   

Export aliases for FBXO9 gene to outside databases

Previous GC identifers: GC06P052931 GC06P052976 GC06P053037 GC06P052761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO9 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants
diverging at the 5' terminus. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO9 Gene:
FBXO9 (F-box protein 9) is a protein-coding gene. Diseases associated with FBXO9 include juvenile myoclonic epilepsy, and multiple myeloma. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: FBX9_HUMAN, Q9UK97
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent
manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2
when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In
contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2
complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is
activated due to the relief of feedback inhibition by mTORC1

Gene Wiki entry for FBXO9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO9 gene promoter:
         SRY   STAT5A   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXO9 promoter sequence
   Search Chromatin IP Primers for FBXO9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3-p11.2   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.3-p11.2

FBXO9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P052916:  view genomic region     (about GC identifiers)

Start:
52,916,789 bp from pter      End:
52,965,671 bp from pter
Size:
48,883 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FBX9_HUMAN, Q9UK97 (See protein sequence)
Recommended Name: F-box only protein 9  
Size: 447 amino acids; 52329 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1,
RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2
Miscellaneous: Overexpressed in multiple myeloma leading to constitutive activation of the PI(3)K/mTORC2/Akt
pathway to promote survival (PubMed:23263282)
Secondary accessions: A6NFW3 B3KMM6 O75986 Q59EH8 Q6PKH7 Q9NT57 Q9Y593
Alternative splicing: 3 isoforms:  Q9UK97-1   Q9UK97-2   Q9UK97-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO9: NX_Q9UK97

Explore proteomics data for FBXO9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115
  • Modification sites at PhosphoSitePlus

  • See FBXO9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_036479.1  NP_258441.1  NP_258442.2  

    ENSEMBL proteins: 
     ENSP00000417154   ENSP00000418858   ENSP00000359977   ENSP00000326968   ENSP00000420536  
     ENSP00000244426   ENSP00000477487   ENSP00000417349  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UK97

    ProtoNet protein and cluster: Q9UK97

    UniProtKB/Swiss-Prot: FBX9_HUMAN, Q9UK97
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 TPR repeat


    FBXO9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX9_HUMAN, Q9UK97
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent
    manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2
    when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In
    contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2
    complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is
    activated due to the relief of feedback inhibition by mTORC1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI--
         
    FBXO9 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FBXO9:
     Increased cell death HMECs cel  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         1 MGI phenotypic allele for Fbxo9 (no phenotypes)

    FBXO9 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO9
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO9
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    Selected qRT-PCR Assays for microRNAs that regulate FBXO9 (see all 32):
    hsa-miR-607 hsa-miR-188-5p hsa-miR-578 hsa-miR-488 hsa-miR-301a hsa-miR-4330 hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidFBXO9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO9

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    GenScript: all cDNA clones in your preferred vector (see all 3): FBXO9 (NM_012347)
    Sino Biological Human cDNA Clone for FBXO9
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX9_HUMAN, Q9UK97: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005737cytoplasm IDA--
    GO:0019005SCF ubiquitin ligase complex IDA--

    FBXO9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: FBX9_HUMAN, Q9UK97
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO9: 

              Parkinson's Disease in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for FBXO9 (Q9UK973 ENSP000002444264) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SKP1P632083, ENSP000002314874I2D: score=1 STRING: ENSP00000231487
    CDC42P609533I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA--
    GO:0032006regulation of TOR signaling IMP--

    FBXO9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO9 (FBX9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FBXO9 gene (3 alternative transcripts): 
    NM_012347.4  NM_033480.2  NM_033481.3  

    Unigene Cluster for FBXO9:

    F-box protein 9
    Hs.216653  [show with all ESTs]
    Unigene Representative Sequence: NM_033480
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459845 ENST00000498744 ENST00000370939 ENST00000461222 ENST00000323557
    ENST00000473337 ENST00000244426(uc021zao.1 uc021zap.1 uc021zaq.1 uc021zar.1 uc021zas.1)
    ENST00000468481 ENST00000480463 ENST00000484812 ENST00000474457 ENST00000484436
    ENST00000473318

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FBXO9 (see all 32):
    hsa-miR-607 hsa-miR-188-5p hsa-miR-578 hsa-miR-488 hsa-miR-301a hsa-miR-4330 hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidFBXO9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO9
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): FBXO9 (NM_012347)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO9
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO9
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO9
      QuantiFast Probe-based Assays in human, mouse, rat FBXO9

    Additional mRNA sequence: 

    AB209833.1 AF174597.1 AF176704.1 AK021559.1 AK056771.1 AL137520.1 AY858798.1 BC000650.2 
    BC024973.2 

    18 DOTS entries:

    DT.318072  DT.204308  DT.100791348  DT.100791349  DT.91735525  DT.87016693  DT.318076  DT.107964 
    DT.95185634  DT.91981631  DT.100773327  DT.40233503  DT.121319731  DT.95185754  DT.95243940  DT.40260503 
    DT.40271184  DT.97863134 

    Selected AceView cDNA sequences (see all 291):

    CD557350 AW952485 AI278540 AA211485 H97012 CB122411 BE677881 AI670733 
    BM977302 AI380926 AA579574 AA767424 BE772335 AU117691 AA953618 AA827171 
    CA771192 AA576177 AK021559 BM693676 NM_033481 BF197353 CA943590 BC000650 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXO9 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:        -                                                     -           -                 -                     
    SP2:                                                                                                                  
    SP3:                                                              -                                                   
    SP4:                                                                                            -                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for FBXO9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATAGTGTT
    FBXO9 Expression
    About this image

    FBXO9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.216653
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO9: 
              Parkinson's Disease in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FBXO9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXO9 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo91 , 5 f-box protein 91, 5 87.92(n)1
    91.51(a)1
      9 (43.53 cM)5
    715381  NM_023605.21  NP_076094.21 
     780814995 
    chicken
    (Gallus gallus)
    Aves FBXO91 F-box protein 9 79.57(n)
    85.02(a)
      421895  NM_001006414.1  NP_001006414.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO96
    F-box protein 9
    85(a)
    1 ↔ 1
    1(151626696-151658789)
    African clawed frog
    (Xenopus laevis)
    Amphibia fbxo9-prov2 F-box only protein 9 75.29(n)    BC054961.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc79g122 wufc79g12 74.29(n)   325469  BC063957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59611 , 3 CG59611 35(a)3
    45.95(n)1
    38.83(a)1
      87B113
    415411  NM_141949.31  NP_650206.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRT3(YLR097C)4 Putative SCF-ubiquitin ligase F-box protein, based more   --   12(337265-336231) 850786  NP_013198.1 


    ENSEMBL Gene Tree for FBXO9 (if available)
    TreeFam Gene Tree for FBXO9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO9 (see all 623)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495664871,2
    C--52928787(+) AGGAGA/GCTGAG 2 -- us2k10--------
    rs1443685091,2
    --52928838(+) TAGCCG/TAGATG 2 -- us2k10--------
    rs1393513641,2
    --52928946(+) CTTCAC/TTCTCT 2 -- us2k10--------
    rs132057841,2
    C--52928952(+) TCTCTC/TGCTCT 2 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1822126221,2
    --52928969(+) TCCCTC/TAGCAC 2 -- us2k10--------
    rs1432062981,2
    --52928983(+) CACCTC/TCATTT 2 -- us2k10--------
    rs114016391,2
    C--52929010(+) TTTTTT/-GAGAC 2 -- us2k1 trp31Minor allele frequency- -:0.00CSA 2
    rs1475203191,2
    --52929135(+) ACTGGG/TATTAC 2 -- us2k10--------
    rs1395408541,2
    --52929202(+) ACCATA/GTTGGT 2 -- us2k10--------
    rs1871787711,2
    --52929297(+) CCAGCC/GGATAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXO9 (52916789 - 52965671 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FBXO9: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO9
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609091    OMIM disorders: --

    6 diseases for FBXO9:    
    About MalaCards
    juvenile myoclonic epilepsy    multiple myeloma    myeloma    renal cell carcinoma
    parkinson's disease    malaria


    FBXO9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for FBXO9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO9 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with FBXO9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. (PubMed id 23263282)2 Fernandez-Saiz V....Bassermann F. (Nat. Cell Biol. 2013)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26268 HGNC: 13588 AceView: FBXO9 Ensembl:ENSG00000112146 euGenes: HUgn26268
    ECgene: FBXO9 H-InvDB: FBXO9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FBXO9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FBXO9 gene:
    Search GeneIP for patents involving FBXO9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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