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Aliases for FBXO9 Gene

Aliases for FBXO9 Gene

  • F-Box Protein 9 2 3 5
  • Renal Carcinoma Antigen NY-REN-57 3 4
  • Cross-Immune Reaction Antigen 1 3 4
  • VCIA1 3 4
  • FBX9 3 4
  • F-Box Only Protein 9 2
  • F-Box Protein Fbx9 3
  • DJ341E18.2 3
  • NY-REN-57 3

External Ids for FBXO9 Gene

Previous GeneCards Identifiers for FBXO9 Gene

  • GC06P052931
  • GC06P052976
  • GC06P052916
  • GC06P052761

Summaries for FBXO9 Gene

Entrez Gene Summary for FBXO9 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO9 Gene

FBXO9 (F-Box Protein 9) is a Protein Coding gene. Diseases associated with FBXO9 include Multiple Myeloma and Epilepsy, Generalized, With Febrile Seizures Plus, Type 5. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO9 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Gene Wiki entry for FBXO9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO9 Gene

Genomics for FBXO9 Gene

Regulatory Elements for FBXO9 Gene

Enhancers for FBXO9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO9 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO9 Gene

Chromosome:
6
Start:
53,051,991 bp from pter
End:
53,100,873 bp from pter
Size:
48,883 bases
Orientation:
Plus strand

Genomic View for FBXO9 Gene

Genes around FBXO9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO9 Gene

Proteins for FBXO9 Gene

  • Protein details for FBXO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK97-FBX9_HUMAN
    Recommended name:
    F-box only protein 9
    Protein Accession:
    Q9UK97
    Secondary Accessions:
    • A6NFW3
    • B3KMM6
    • O75986
    • Q59EH8
    • Q6PKH7
    • Q9NT57
    • Q9Y593

    Protein attributes for FBXO9 Gene

    Size:
    447 amino acids
    Molecular mass:
    52329 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
    Miscellaneous:
    • Overexpressed in multiple myeloma leading to constitutive activation of the PI(3)K/mTORC2/Akt pathway to promote survival.

    Alternative splice isoforms for FBXO9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO9 Gene

Proteomics data for FBXO9 Gene at MOPED

Post-translational modifications for FBXO9 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXO9 Gene

Domains & Families for FBXO9 Gene

Gene Families for FBXO9 Gene

Protein Domains for FBXO9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK97

UniProtKB/Swiss-Prot:

FBX9_HUMAN :
  • Contains 1 F-box domain.
  • Contains 1 TPR repeat.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with FBXO9: view

Function for FBXO9 Gene

Molecular function for FBXO9 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
genes like me logo Genes that share phenotypes with FBXO9: view

Animal Models for FBXO9 Gene

MGI Knock Outs for FBXO9:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO9 Gene

Localization for FBXO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO9 Gene COMPARTMENTS Subcellular localization image for FBXO9 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 23263282
genes like me logo Genes that share ontologies with FBXO9: view

Pathways & Interactions for FBXO9 Gene

SuperPathways for FBXO9 Gene

No Data Available

UniProtKB/Swiss-Prot Q9UK97-FBX9_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for FBXO9 Gene

Gene Ontology (GO) - Biological Process for FBXO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 23263282
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with FBXO9: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO9 Gene

Drugs & Compounds for FBXO9 Gene

No Compound Related Data Available

Transcripts for FBXO9 Gene

Unigene Clusters for FBXO9 Gene

F-box protein 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - -
SP2:
SP3: -
SP4: -
SP5:
SP6:

Relevant External Links for FBXO9 Gene

GeneLoc Exon Structure for
FBXO9
ECgene alternative splicing isoforms for
FBXO9

Expression for FBXO9 Gene

mRNA expression in normal human tissues for FBXO9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO9 Gene

This gene is overexpressed in Urinary Bladder (47.4) and CD8 Tcells (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO9 Gene



SOURCE GeneReport for Unigene cluster for FBXO9 Gene Hs.216653

genes like me logo Genes that share expression patterns with FBXO9: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXO9 Gene

Orthologs for FBXO9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXO9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO9 35
  • 90.44 (n)
  • 94.04 (a)
FBXO9 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO9 35
  • 94.56 (n)
  • 95.63 (a)
FBXO9 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo9 35
  • 87.92 (n)
  • 91.51 (a)
Fbxo9 16
Fbxo9 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO9 35
  • 99.62 (n)
  • 99.77 (a)
FBXO9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo9 35
  • 89.89 (n)
  • 92.41 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO9 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves FBXO9 35
  • 79.57 (n)
  • 85.02 (a)
FBXO9 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO9 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo9 35
  • 74.92 (n)
  • 74.76 (a)
MGC75727 35
African clawed frog
(Xenopus laevis)
Amphibia fbxo9-prov 35
zebrafish
(Danio rerio)
Actinopterygii fbxo9 35
  • 67.7 (n)
  • 70.24 (a)
wufc79g12 35
fbxo9 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.856 35
fruit fly
(Drosophila melanogaster)
Insecta CG5961 37
  • 35 (a)
CG5961 35
  • 45.95 (n)
  • 38.83 (a)
CG5961 36
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006784 35
  • 49.4 (n)
  • 41.45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRT3 36
  • 23 (a)
OneToOne
HRT3 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for FBXO9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO9 Gene

ENSEMBL:
Gene Tree for FBXO9 (if available)
TreeFam:
Gene Tree for FBXO9 (if available)

Paralogs for FBXO9 Gene

No data available for Paralogs for FBXO9 Gene

Variants for FBXO9 Gene

Sequence variations from dbSNP and Humsavar for FBXO9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1016764 -- 53,096,388(+) AATTC(C/T)GAGAG intron-variant
rs1127834 -- 53,097,928(+) TGTGT(A/G)TATAT utr-variant-3-prime
rs1127835 -- 53,097,932(+) tatat(A/G)tatat utr-variant-3-prime
rs1127836 -- 53,097,934(+) tatat(A/G)tatat utr-variant-3-prime
rs1127838 -- 53,097,938(+) tatat(A/G)tatat utr-variant-3-prime

Variation tolerance for FBXO9 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FBXO9 Gene

Disorders for FBXO9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FBXO9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multiple myeloma
  • plasma cell neoplasm
epilepsy, generalized, with febrile seizures plus, type 5
  • epilepsy, idiopathic generalized, 10
- elite association - COSMIC cancer census association via MalaCards
Search FBXO9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FBXO9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO9
genes like me logo Genes that share disorders with FBXO9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO9 Gene

Publications for FBXO9 Gene

  1. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 67
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for FBXO9 Gene

Sources for FBXO9 Gene

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