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Aliases for FBXO9 Gene

Aliases for FBXO9 Gene

  • F-Box Protein 9 2 3
  • FBX9 3 4 6
  • Renal Carcinoma Antigen NY-REN-57 3 4
  • Cross-Immune Reaction Antigen 1 3 4
  • F-Box Only Protein 9 2 3
  • VCIA1 3 4
  • F-Box Protein Fbx9 3
  • DJ341E18.2 3
  • NY-REN-57 3

External Ids for FBXO9 Gene

Summaries for FBXO9 Gene

Entrez Gene Summary for FBXO9 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO9 Gene

FBXO9 (F-Box Protein 9) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO9 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Gene Wiki entry for FBXO9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO9 Gene

Genomics for FBXO9 Gene

Genomic Location for FBXO9 Gene

Start:
53,051,991 bp from pter
End:
53,100,873 bp from pter
Size:
48,883 bases
Orientation:
Plus strand

Genomic View for FBXO9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO9 Gene

Regulatory Elements for FBXO9 Gene

Proteins for FBXO9 Gene

  • Protein details for FBXO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK97-FBX9_HUMAN
    Recommended name:
    F-box only protein 9
    Protein Accession:
    Q9UK97
    Secondary Accessions:
    • A6NFW3
    • B3KMM6
    • O75986
    • Q59EH8
    • Q6PKH7
    • Q9NT57
    • Q9Y593

    Protein attributes for FBXO9 Gene

    Size:
    447 amino acids
    Molecular mass:
    52329 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
    Miscellaneous:
    • Overexpressed in multiple myeloma leading to constitutive activation of the PI(3)K/mTORC2/Akt pathway to promote survival.

    Alternative splice isoforms for FBXO9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO9 Gene

Proteomics data for FBXO9 Gene at MOPED

Post-translational modifications for FBXO9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys115

No data available for DME Specific Peptides for FBXO9 Gene

Domains for FBXO9 Gene

Gene Families for FBXO9 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK97

UniProtKB/Swiss-Prot:

FBX9_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q9UK97
Similarity:
  • Contains 1 TPR repeat.:
    • Q9UK97
genes like me logo Genes that share domains with FBXO9: view

Function for FBXO9 Gene

Molecular function for FBXO9 Gene

UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Gene Ontology (GO) - Molecular Function for FBXO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IPI 23263282
genes like me logo Genes that share ontologies with FBXO9: view
genes like me logo Genes that share phenotypes with FBXO9: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO9 Gene

Localization for FBXO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO9 Gene COMPARTMENTS Subcellular localization image for FBXO9 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005737 cytoplasm IDA 23263282
GO:0019005 SCF ubiquitin ligase complex IDA 23263282
genes like me logo Genes that share ontologies with FBXO9: view

Pathways for FBXO9 Gene

SuperPathways for FBXO9 Gene

No Data Available

UniProtKB/Swiss-Prot Q9UK97-FBX9_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for FBXO9 Gene

Gene Ontology (GO) - Biological Process for FBXO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 23263282
GO:0032006 regulation of TOR signaling IMP 23263282
GO:0045087 innate immune response IEA --
GO:0045444 fat cell differentiation IEA --
genes like me logo Genes that share ontologies with FBXO9: view

No data available for Pathways by source for FBXO9 Gene

Transcripts for FBXO9 Gene

Unigene Clusters for FBXO9 Gene

F-box protein 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - -
SP2:
SP3: -
SP4: -
SP5:
SP6:

Relevant External Links for FBXO9 Gene

GeneLoc Exon Structure for
FBXO9
ECgene alternative splicing isoforms for
FBXO9

Expression for FBXO9 Gene

mRNA expression in normal human tissues for FBXO9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO9 Gene

SOURCE GeneReport for Unigene cluster for FBXO9 Gene Hs.216653

genes like me logo Genes that share expressions with FBXO9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO9 Gene

Orthologs for FBXO9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXO9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO9 35
  • 99.62 (n)
  • 99.77 (a)
FBXO9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO9 35
  • 90.44 (n)
  • 94.04 (a)
FBXO9 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO9 35
  • 94.56 (n)
  • 95.63 (a)
FBXO9 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo9 35
  • 87.92 (n)
  • 91.51 (a)
Fbxo9 16
Fbxo9 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO9 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxo9 35
  • 89.89 (n)
  • 92.41 (a)
chicken
(Gallus gallus)
Aves FBXO9 35
  • 79.57 (n)
  • 85.02 (a)
FBXO9 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO9 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fbxo9-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo9 35
  • 74.92 (n)
  • 74.76 (a)
MGC75727 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.856 35
zebrafish
(Danio rerio)
Actinopterygii fbxo9 35
  • 67.7 (n)
  • 70.24 (a)
fbxo9 36
  • 69 (a)
OneToOne
wufc79g12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006784 35
  • 49.4 (n)
  • 41.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5961 35
  • 45.95 (n)
  • 38.83 (a)
CG5961 36
  • 35 (a)
OneToOne
CG5961 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRT3 36
  • 23 (a)
OneToOne
HRT3 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for FBXO9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO9 Gene

ENSEMBL:
Gene Tree for FBXO9 (if available)
TreeFam:
Gene Tree for FBXO9 (if available)

Paralogs for FBXO9 Gene

No data available for Paralogs for FBXO9 Gene

Variants for FBXO9 Gene

Sequence variations from dbSNP and Humsavar for FBXO9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2876 -- 53,098,273(+) GCATA(A/G)TGTTT utr-variant-3-prime
rs149366 -- 53,077,229(-) ccaaa(A/G)tgctg intron-variant
rs149409 -- 53,077,322(-) taatt(G/T)tttgt intron-variant
rs149593 -- 53,077,384(-) gccat(A/T)ctcct intron-variant
rs149594 -- 53,077,244(-) gcccg(A/C)ctcgg intron-variant

Relevant External Links for FBXO9 Gene

HapMap Linkage Disequilibrium report
FBXO9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO9 Gene

Disorders for FBXO9 Gene

No disorders were found for FBXO9 Gene.

No data available for UniProtKB/Swiss-Prot for FBXO9 Gene

Publications for FBXO9 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4
  3. SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. (PMID: 23263282) Fernandez-Saiz V. … Bassermann F. (Nat. Cell Biol. 2013) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FBXO9 Gene

Sources for FBXO9 Gene

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