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Aliases for FBXO8 Gene

Aliases for FBXO8 Gene

  • F-Box Protein 8 2 3 5
  • F-Box/SEC7 Protein FBS 3 4
  • FBX8 3 4
  • FBS 3 4
  • F-Box Only Protein 8 2
  • F-Box Protein Fbx8 3
  • DC10 3

External Ids for FBXO8 Gene

Previous GeneCards Identifiers for FBXO8 Gene

  • GC04M176077
  • GC04M175695
  • GC04M175742
  • GC04M175853
  • GC04M175532
  • GC04M175394
  • GC04M175157
  • GC04M170904

Summaries for FBXO8 Gene

Entrez Gene Summary for FBXO8 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO8 Gene

FBXO8 (F-Box Protein 8) is a Protein Coding gene. Diseases associated with FBXO8 include Patent Foramen Ovale. Among its related pathways are Arf6 signaling events. GO annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465.

UniProtKB/Swiss-Prot for FBXO8 Gene

  • May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO8 Gene

Genomics for FBXO8 Gene

Regulatory Elements for FBXO8 Gene

Enhancers for FBXO8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO8 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO8 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO8 Gene

174,236,658 bp from pter
174,284,264 bp from pter
47,607 bases
Minus strand

Genomic View for FBXO8 Gene

Genes around FBXO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO8 Gene

Proteins for FBXO8 Gene

  • Protein details for FBXO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 8
    Protein Accession:
    Secondary Accessions:
    • B2RB40
    • D3DP41
    • G5E9Z0
    • Q6UWN4
    • Q8IWE1
    • Q9NRP5
    • Q9UKC4

    Protein attributes for FBXO8 Gene

    319 amino acids
    Molecular mass:
    37068 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF04517.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO8 Gene


neXtProt entry for FBXO8 Gene

Proteomics data for FBXO8 Gene at MOPED

Post-translational modifications for FBXO8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO8 Gene

No data available for DME Specific Peptides for FBXO8 Gene

Domains & Families for FBXO8 Gene

Gene Families for FBXO8 Gene

Protein Domains for FBXO8 Gene

Suggested Antigen Peptide Sequences for FBXO8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
  • Contains 1 SEC7 domain.
genes like me logo Genes that share domains with FBXO8: view

Function for FBXO8 Gene

Molecular function for FBXO8 Gene

UniProtKB/Swiss-Prot Function:
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).

Gene Ontology (GO) - Molecular Function for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with FBXO8: view
genes like me logo Genes that share phenotypes with FBXO8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO8 Gene

Localization for FBXO8 Gene

Subcellular locations from

Jensen Localization Image for FBXO8 Gene COMPARTMENTS Subcellular localization image for FBXO8 gene
Compartment Confidence
cytosol 3
nucleus 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO8 Gene

Pathways & Interactions for FBXO8 Gene

SuperPathways for FBXO8 Gene

Superpath Contained pathways
1 Arf6 signaling events
genes like me logo Genes that share pathways with FBXO8: view

Pathways by source for FBXO8 Gene

1 BioSystems pathway for FBXO8 Gene

Gene Ontology (GO) - Biological Process for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with FBXO8: view

No data available for SIGNOR curated interactions for FBXO8 Gene

Drugs & Compounds for FBXO8 Gene

(1) Drugs for FBXO8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with FBXO8: view

Transcripts for FBXO8 Gene

Unigene Clusters for FBXO8 Gene

F-box protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP3: - -
SP5: - - -

Relevant External Links for FBXO8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO8 Gene

mRNA expression in normal human tissues for FBXO8 Gene

Protein differential expression in normal tissues from HIPED for FBXO8 Gene

This gene is overexpressed in Bone (54.8) and Breast (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO8 Gene

SOURCE GeneReport for Unigene cluster for FBXO8 Gene Hs.76917

genes like me logo Genes that share expression patterns with FBXO8: view

Protein tissue co-expression partners for FBXO8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO8 Gene

Orthologs for FBXO8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO8 35
  • 93.31 (n)
  • 97.18 (a)
FBXO8 36
  • 97 (a)
(Canis familiaris)
Mammalia FBXO8 35
  • 95.19 (n)
  • 97.81 (a)
FBXO8 36
  • 97 (a)
(Mus musculus)
Mammalia Fbxo8 35
  • 92.16 (n)
  • 95.92 (a)
Fbxo8 16
Fbxo8 36
  • 96 (a)
(Pan troglodytes)
Mammalia FBXO8 35
  • 99.58 (n)
  • 100 (a)
FBXO8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo8 35
  • 91.85 (n)
  • 95.92 (a)
(Monodelphis domestica)
Mammalia FBXO8 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO8 36
  • 74 (a)
(Gallus gallus)
Aves FBXO8 35
  • 86.42 (n)
  • 95.92 (a)
FBXO8 36
  • 96 (a)
(Anolis carolinensis)
Reptilia FBXO8 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo8 35
  • 76.27 (n)
  • 82.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18650 35
(Danio rerio)
Actinopterygii fbxo8 35
  • 70.55 (n)
  • 81.13 (a)
fbxo8 36
  • 79 (a)
(Caenorhabditis elegans)
Secernentea M02B7.5 36
  • 10 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.713 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8763 36
  • 51 (a)
Species with no ortholog for FBXO8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO8 Gene

Gene Tree for FBXO8 (if available)
Gene Tree for FBXO8 (if available)

Paralogs for FBXO8 Gene

(2) SIMAP similar genes for FBXO8 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FBXO8: view

Variants for FBXO8 Gene

Sequence variations from dbSNP and Humsavar for FBXO8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036157 A breast cancer sample
rs17857220 - 174,262,940(+) ATGTC(A/C)ATGCC nc-transcript-variant, reference, missense
rs17854000 - 174,241,209(+) AAAGT(A/G)GTTCA nc-transcript-variant, reference, missense
rs14278 -- 174,237,261(-) TTTCT(A/G)TTTTA utr-variant-3-prime
rs980900 -- 174,246,545(-) TTGTA(A/C)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO8 Gene

Variant ID Type Subtype PubMed ID
nsv881449 CNV Gain 21882294
esv2728766 CNV Deletion 23290073
esv2123340 CNV Deletion 18987734

Variation tolerance for FBXO8 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO8 Gene

Disorders for FBXO8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
patent foramen ovale
  • atrial septal defect within oval fossa
- elite association - COSMIC cancer census association via MalaCards
Search FBXO8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FBXO8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FBXO8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO8 Gene

Publications for FBXO8 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 67
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. Significance of FBX8 in progression of gastric cancer. (PMID: 25801334) Wu P. … Liang L. (Exp. Mol. Pathol. 2015) 3
  5. Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma. (PMID: 25550853) Yu Y. … Zhao G. (Int J Clin Exp Pathol 2014) 3

Products for FBXO8 Gene

Sources for FBXO8 Gene