Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXO8 Gene

protein-coding   GIFtS: 50
GCID: GC04M175157

F-Box Protein 8

(Previous name: F-box only protein 8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box Protein 81 2
FBS2 3 5
FBX82 3 5
F-Box Only Protein 81 2
F-Box/SEC7 Protein FBS2 3
F-Box Protein Fbx82

External Ids:    HGNC: 135871   Entrez Gene: 262692   Ensembl: ENSG000001641177   OMIM: 6056495   UniProtKB: Q9NRD03   

Export aliases for FBXO8 gene to outside databases

Previous GC identifers: GC04M176077 GC04M175695 GC04M175742 GC04M175853 GC04M175532 GC04M175394 GC04M170904


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXO8 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant
similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein
may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor)
activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO8 Gene:
FBXO8 (F-box protein 8) is a protein-coding gene. Diseases associated with FBXO8 include breast and colorectal cancer, and colorectal cancer. GO annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: FBX8_HUMAN, Q9NRD0
Function: May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of
GDP with GTP (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO8 gene promoter:
         NCX/Ncx   HTF   LUN-1   Cdc5   MZF-1   AREB6   RORalpha1   POU2F1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXO8 promoter sequence
   Search Chromatin IP Primers for FBXO8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q34.1

FBXO8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M175157:  view genomic region     (about GC identifiers)

Start:
175,157,809 bp from pter      End:
175,205,415 bp from pter
Size:
47,607 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBX8_HUMAN, Q9NRD0 (See protein sequence)
Recommended Name: F-box only protein 8  
Size: 319 amino acids; 37068 Da
Sequence caution: Sequence=AAF04517.1; Type=Erroneous initiation;
Secondary accessions: B2RB40 D3DP41 Q6UWN4 Q9NRP5 Q9UKC4

Explore the universe of human proteins at neXtProt for FBXO8: NX_Q9NRD0

Explore proteomics data for FBXO8 at MOPED


See FBXO8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036312.2  
ENSEMBL proteins: 
 ENSP00000377280   ENSP00000422905   ENSP00000427313   ENSP00000427506  

FBXO8 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for FBXO8
OriGene Custom MassSpec
OriGene Custom Protein Services for FBXO8
GenScript Custom Purified and Recombinant Proteins Services for FBXO8
Novus Biologicals FBXO8 Proteins
Novus Biologicals FBXO8 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for FBXO8

FBXO8 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for FBXO8
Novus Biologicals FBXO8 Antibodies
Abcam antibodies for FBXO8
Cloud-Clone Corp. Antibodies for FBXO8
ThermoFisher Antibody for FBXO8
LSBio Antibodies in human, mouse, rat for FBXO8

FBXO8 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for FBXO8
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for FBXO8
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for FBXO8
Cloud-Clone Corp. CLIAs for FBXO8


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
FBXO: F-boxes / "other"

3 InterPro protein domains:
 IPR023394 Sec7_alpha_orthog
 IPR001810 F-box_dom
 IPR000904 Sec7_dom

Graphical View of Domain Structure for InterPro Entry Q9NRD0

ProtoNet protein and cluster: Q9NRD0

1 Blocks protein domain: IPB000904 SEC7-like domain

UniProtKB/Swiss-Prot: FBX8_HUMAN, Q9NRD0
Similarity: Contains 1 F-box domain
Similarity: Contains 1 SEC7 domain


FBXO8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FBX8_HUMAN, Q9NRD0
Function: May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of
GDP with GTP (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
GO:0005515protein binding ----
     
FBXO8 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO8

miRNA
Products:
    
miRTarBase miRNAs that target FBXO8:
hsa-mir-375 (MIRT019812), hsa-mir-19b-3p (MIRT031200)

Block miRNA regulation of human, mouse, rat FBXO8 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FBXO8 (see all 11):
hsa-miR-3163 hsa-miR-4328 hsa-miR-634 hsa-miR-561 hsa-miR-216b hsa-miR-218 hsa-miR-223 hsa-miR-544
SwitchGear 3'UTR luciferase reporter plasmidFBXO8 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for FBXO8
Predesigned siRNA for gene silencing in human, mouse, rat FBXO8

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for FBXO8

Clone
Products:
     
OriGene clones in human, mouse for FBXO8 (see all 8)
OriGene ORF clones in mouse, rat for FBXO8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FBXO8 (NM_012180)
Sino Biological Human cDNA Clone for FBXO8
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO8

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for FBXO8
Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO8 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
endoplasmic reticulum1
mitochondrion1
peroxisome1
plasma membrane1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000151ubiquitin ligase complex NAS10945468
GO:0005634nucleus IBA--
GO:0005802NOT trans-Golgi network IBA--
GO:0030054cell junction IBA--

FBXO8 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for FBXO8 About    
See pathways by source

SuperPathContained pathways About
1Arf6 signaling events
Arf6 signaling events


1 BioSystems Pathway for FBXO8
    Arf6 signaling events



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO8
Interactions:

    Search GeneGlobe Interaction Network for FBXO8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for FBXO8 (Q9NRD03 ENSP000003772804) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
InteractantInteraction Details
GeneCardExternal ID(s)
SKP1P632083, ENSP000002314874I2D: score=3 STRING: ENSP00000231487
CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
MYCENSP000003672074STRING: ENSP00000367207
About this table

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006511ubiquitin-dependent protein catabolic process NAS10945468
GO:0016192NOT vesicle-mediated transport IBA--
GO:0030036actin cytoskeleton organization IBA--
GO:0032012regulation of ARF protein signal transduction IEA--
GO:0043087regulation of GTPase activity IBA--

FBXO8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FBXO8 (FBX8)

1 HMDB Compound for FBXO8    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine triphosphate5'-GTP (see all 10)86-01-1--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for FBXO8 gene: 
NM_012180.2  

Unigene Cluster for FBXO8:

F-box protein 8
Hs.76917  [show with all ESTs]
Unigene Representative Sequence: NM_012180
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000393674(uc003itp.3 uc003itq.3) ENST00000503293 ENST00000515664
ENST00000513696
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat FBXO8 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FBXO8 (see all 11):
hsa-miR-3163 hsa-miR-4328 hsa-miR-634 hsa-miR-561 hsa-miR-216b hsa-miR-218 hsa-miR-223 hsa-miR-544
SwitchGear 3'UTR luciferase reporter plasmidFBXO8 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FBXO8
Predesigned siRNA for gene silencing in human, mouse, rat FBXO8
Clone
Products:
     
OriGene clones in human, mouse for FBXO8 (see all 8)
OriGene ORF clones in mouse, rat for FBXO8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FBXO8 (NM_012180)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO8
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FBXO8
OriGene qSTAR qPCR primer pairs in human, mouse for FBXO8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO8
  QuantiTect SYBR Green Assays in human, mouse, rat FBXO8
  QuantiFast Probe-based Assays in human, mouse, rat FBXO8

Additional mRNA sequence: 

AF115514.1 AF174596.1 AF201932.1 AF233224.1 AK026319.1 AK123740.1 AK314483.1 AY358721.1 
BC014679.2 BC014903.1 BC040456.1 

9 DOTS entries:

DT.453294  DT.100793143  DT.100766227  DT.95200782  DT.100028146  DT.121271481  DT.92439080  DT.95156583 
DT.100793140 

Selected AceView cDNA sequences (see all 217):

BM920167 AL556594 AW772304 AY358721 BI827173 NM_012180 AA933777 AW516309 
CR621638 BI791572 AK026319 BC014903 BM920781 CD108902 BU627340 AI472064 
AI148083 CR617381 BM021360 BQ023292 CR603561 BI225297 BG200344 BM314469 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO8    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1:                                            -     -                                 
SP2:                                                                                    
SP3:                                            -     -                                 
SP4:                                                                                    
SP5:                                      -     -     -                                 


ECgene alternative splicing isoforms for FBXO8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

FBXO8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FBXO8 Expression
About this image

FBXO8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FBXO8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.76917
    Custom PCR Arrays for FBXO8
Primer
Products:
OriGene qPCR primer pairs and template standards for FBXO8
OriGene qSTAR qPCR primer pairs in human, mouse for FBXO8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO8
QuantiTect SYBR Green Assays in human, mouse, rat FBXO8
QuantiFast Probe-based Assays in human, mouse, rat FBXO8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for FBXO8 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fbxo81 , 5 F-box protein 81, 5 92.16(n)1
95.92(a)1
  8 (29.70 cM)5
507531  NM_015791.31  NP_056606.21 
 565510905 
chicken
(Gallus gallus)
Aves FBXO81 F-box protein 8 86.42(n)
95.92(a)
  422565  NM_001006446.1  NP_001006446.1 
lizard
(Anolis carolinensis)
Reptilia FBXO86
F-box protein 8
94(a)
1 ↔ 1
3(144007652-144020238)
African clawed frog
(Xenopus laevis)
Amphibia Xl.186502 Xenopus laevis transcribed sequence with strong similarity more 82.61(n)    BI443365.1 
zebrafish
(Danio rerio)
Actinopterygii fbxo81 F-box protein 8 70.55(n)
81.13(a)
  678549  NM_001040307.1  NP_001035397.1 
worm
(Caenorhabditis elegans)
Secernentea M02B7.56
Protein M02B7.5 (M02B7.5) mRNA, complete cds
10(a)
1 ↔ 1
IV(3807666-3819323) WBGene00019726


ENSEMBL Gene Tree for FBXO8 (if available)
TreeFam Gene Tree for FBXO8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for FBXO8 gene
CYTH32  IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  IQSEC12  IQSEC22  
CYTH42  CYTH12  
2 SIMAP similar genes for FBXO8 using alignment to 6 protein entries:     FBX8_HUMAN (see all proteins):
MST051    FBXO11

FBXO8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for FBXO8 (see all 764)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0361574
A breast cancer sample4--see VAR_0361572 L I mis40--------
rs1820648231,2
--175157389(+) TCCCTC/TCTCTA 1 -- ds50010--------
rs730094811,2
C--175157546(+) ATATAC/TTTCAT 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs1400772231,2
C--175157574(+) GCAGA-/TTTTTT 1 -- ds50010--------
rs2021942781,2
C--175157580(+) TTTTT-/A/TCTTCT 1 -- ds50010--------
rs1395283531,2
C--175157614(+) GTGAGA/CGCAGG 1 -- ds50010--------
rs1877631921,2
--175157637(+) TACCTC/TGCACA 1 -- ds50010--------
rs1924757091,2
--175157651(+) TTAACA/GCATGT 1 -- ds50010--------
rs173571201,2
C,F,H--175157743(+) TGAACG/AGGGAT 1 -- ds500122Minor allele frequency- A:0.29NA NS EA WA CSA 2362
rs754389051,2
C--175157944(+) TCAAAA/TTATAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for FBXO8 (175157809 - 175205415 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FBXO8:    About this table    
Variant IDTypeSubtypePubMed ID
esv2728766CNV Deletion23290073
esv2123340CNV Deletion18987734
nsv881449CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FBXO8
DNA2.0 Custom Variant and Variant Library Synthesis for FBXO8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 605649    OMIM disorders: --

2 diseases for FBXO8:    
About MalaCards
breast and colorectal cancer    colorectal cancer


FBXO8 for disorders           About GeneDecksing

Genetic Association Database (GAD): FBXO8
Human Genome Epidemiology (HuGE) Navigator: FBXO8 (1 document)

Export disorders for FBXO8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for FBXO8 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with FBXO8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
  2. Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1, 4 Cronin S....Hardiman O. (Eur. J. Hum. Genet. 2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  6. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (Genomics 2000)
  7. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
  8. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
  9. c-Myc stimulates cell invasion by inhibiting FBX8 function. (PubMed id 20848231)1 Cho H.J....Kim H. (Mol. Cells 2010)
  10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 26269 HGNC: 13587 AceView: FBXO8 Ensembl:ENSG00000164117 euGenes: HUgn26269
ECgene: FBXO8 H-InvDB: FBXO8

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for FBXO8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for FBXO8 gene:
Search GeneIP for patents involving FBXO8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXO8  
 OriGene qPCR primer pairs and template standards for FBXO8   OriGene Protein Over-expression Lysate for FBXO8  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXO8  
 OriGene qSTAR qPCR primer pairs in human, mouse for FBXO8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for FBXO8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for FBXO8   OriGene Custom Protein Services for FBXO8  

 
 
 Block miRNA regulation of human, mouse, rat FBXO8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXO8
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO8 Predesigned siRNA for gene silencing in human, mouse, rat FBXO8
 QuantiFast Probe-based Assays in human, mouse, rat FBXO8 QuantiTect SYBR Green Assays in human, mouse, rat FBXO8
 Custom PCR Arrays for FBXO8 Search Chromatin IP Primers for FBXO8
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO8  Search GeneGlobe Interaction Network for FBXO8
 Regulatory tfbs in FBXO8 promoter
 GenScript Custom Purified and Recombinant Proteins Services for FBXO8 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO8
 GenScript Custom Assay Services for FBXO8 GenScript Custom overexpressing Cell Line Services for FBXO8
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for FBXO8 (FBX8)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for FBXO8
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 FBXO8 antibodies
 FBXO8 proteins
 FBXO8 lysates
 Antibodies for FBXO8
 See all of Abcam's Antibodies, Kits and Proteins for FBXO8
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for FBXO8
 Antibodies for FBXO8
 ELISAs for FBXO8
 CLIAs for FBXO8



 Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO8
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO8
 SwitchGear 3'UTR luciferase reporter plasmids for FBXO8
 SwitchGear Promoter luciferase reporter plasmids for FBXO8
 ThermoFisher Antibody for FBXO8
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO8
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO8
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO8
 LSBio Antibodies in human, mouse, rat for FBXO8
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      FBXO8 gene at Home site.
Version: 3.12.166 28 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4