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Aliases for FBXO8 Gene

Aliases for FBXO8 Gene

  • F-Box Protein 8 2 3 5
  • F-Box/SEC7 Protein FBS 3 4
  • F-Box Only Protein 8 2 3
  • FBX8 3 4
  • FBS 3 4
  • F-Box Protein Fbx8 3
  • DC10 3

External Ids for FBXO8 Gene

Previous GeneCards Identifiers for FBXO8 Gene

  • GC04M176077
  • GC04M175695
  • GC04M175742
  • GC04M175853
  • GC04M175532
  • GC04M175394
  • GC04M175157
  • GC04M170904

Summaries for FBXO8 Gene

Entrez Gene Summary for FBXO8 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO8 Gene

FBXO8 (F-Box Protein 8) is a Protein Coding gene. Among its related pathways are Arf6 signaling events. GO annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is IQSEC2.

UniProtKB/Swiss-Prot for FBXO8 Gene

  • May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO8 Gene

Genomics for FBXO8 Gene

Regulatory Elements for FBXO8 Gene

Enhancers for FBXO8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F173369 1.1 ENCODE 20 +913.2 913160 4.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FBXO8 CEP44 HMGB2 LOC105377538 HAND2 SCRG1 HAND2-AS1 LOC105377540 LOC101928383
GH04F173414 1.6 FANTOM5 Ensembl ENCODE 13.2 +868.1 868064 3.2 HDGF PKNOX1 ARNT YBX1 ZNF2 ZNF207 MCM3 NCOA1 REST TBX21 CEP44 FBXO8 SAP30 RPL5P11 LOC101928383
GH04F174681 1.3 FANTOM5 ENCODE 13.3 -397.6 -397593 1.2 PKNOX1 ATF1 ARNT CREB3L1 ELK1 GATA2 FOS JUNB NCOA1 REST CEP44 FBXO8 HPGD GC04P174661 GC04M174697
GH04F174217 1.3 FANTOM5 Ensembl ENCODE 10.8 +66.2 66170 1.8 PKNOX1 RNF2 SUZ12 TEAD4 CBX2 RAD21 ZFHX2 CBX8 GLIS2 ZNF692 CEP44 FBXO8 LOC101928509 ENSG00000251213
GH04F173366 0.9 Ensembl ENCODE 9.1 +916.6 916599 1.6 JUN CEBPB JUNB TBX21 ARID1B JUND SCRT2 HMBOX1 CREM PRDM1 HMGB2 LOC105377538 SCRG1 RNU6-1096P CEP44 FBXO8 SAP30 GC04P173358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO8 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FBXO8 Gene

174,236,658 bp from pter
174,284,264 bp from pter
47,607 bases
Minus strand

Genomic View for FBXO8 Gene

Genes around FBXO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO8 Gene

Proteins for FBXO8 Gene

  • Protein details for FBXO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 8
    Protein Accession:
    Secondary Accessions:
    • B2RB40
    • D3DP41
    • G5E9Z0
    • Q6UWN4
    • Q8IWE1
    • Q9NRP5
    • Q9UKC4

    Protein attributes for FBXO8 Gene

    319 amino acids
    Molecular mass:
    37068 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF04517.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO8 Gene


neXtProt entry for FBXO8 Gene

Post-translational modifications for FBXO8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO8 Gene

No data available for DME Specific Peptides for FBXO8 Gene

Domains & Families for FBXO8 Gene

Gene Families for FBXO8 Gene

Protein Domains for FBXO8 Gene

Suggested Antigen Peptide Sequences for FBXO8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
  • Contains 1 SEC7 domain.
genes like me logo Genes that share domains with FBXO8: view

Function for FBXO8 Gene

Molecular function for FBXO8 Gene

UniProtKB/Swiss-Prot Function:
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).

Gene Ontology (GO) - Molecular Function for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005086 ARF guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with FBXO8: view
genes like me logo Genes that share phenotypes with FBXO8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO8 Gene

Localization for FBXO8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO8 gene
Compartment Confidence
nucleus 3
cytosol 3
peroxisome 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10945468
genes like me logo Genes that share ontologies with FBXO8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO8 Gene

Pathways & Interactions for FBXO8 Gene

SuperPathways for FBXO8 Gene

SuperPathway Contained pathways
1 Arf6 signaling events
genes like me logo Genes that share pathways with FBXO8: view

Pathways by source for FBXO8 Gene

1 BioSystems pathway for FBXO8 Gene

Gene Ontology (GO) - Biological Process for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10945468
GO:0032012 regulation of ARF protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with FBXO8: view

No data available for SIGNOR curated interactions for FBXO8 Gene

Drugs & Compounds for FBXO8 Gene

(1) Drugs for FBXO8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with FBXO8: view

Transcripts for FBXO8 Gene

Unigene Clusters for FBXO8 Gene

F-box protein 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP3: - -
SP5: - - -

Relevant External Links for FBXO8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO8 Gene

Protein differential expression in normal tissues from HIPED for FBXO8 Gene

This gene is overexpressed in Bone (54.8) and Breast (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO8 Gene

Protein tissue co-expression partners for FBXO8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO8 Gene:


SOURCE GeneReport for Unigene cluster for FBXO8 Gene:

genes like me logo Genes that share expression patterns with FBXO8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO8 Gene

Orthologs for FBXO8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO8 34 35
  • 99.58 (n)
(Canis familiaris)
Mammalia FBXO8 34 35
  • 95.19 (n)
(Bos Taurus)
Mammalia FBXO8 34 35
  • 93.31 (n)
(Mus musculus)
Mammalia Fbxo8 34 16 35
  • 92.16 (n)
(Rattus norvegicus)
Mammalia Fbxo8 34
  • 91.85 (n)
(Monodelphis domestica)
Mammalia FBXO8 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO8 35
  • 74 (a)
(Gallus gallus)
Aves FBXO8 34 35
  • 86.42 (n)
(Anolis carolinensis)
Reptilia FBXO8 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo8 34
  • 76.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18650 34
(Danio rerio)
Actinopterygii fbxo8 34 35
  • 70.55 (n)
(Caenorhabditis elegans)
Secernentea M02B7.5 35
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8763 35
  • 51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.713 34
Species where no ortholog for FBXO8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO8 Gene

Gene Tree for FBXO8 (if available)
Gene Tree for FBXO8 (if available)

Paralogs for FBXO8 Gene

(2) SIMAP similar genes for FBXO8 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FBXO8: view

Variants for FBXO8 Gene

Sequence variations from dbSNP and Humsavar for FBXO8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036157 A breast cancer sample
rs10026413 -- 174,237,717(+) AAATA(C/T)AGAGT intron-variant
rs10434410 -- 174,253,734(+) TGCTC(C/G)TGTGA intron-variant
rs1050092 -- 174,237,061(-) AAATA(A/C)CATGT utr-variant-3-prime
rs10520275 -- 174,261,426(+) TGGTT(C/G)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO8 Gene

Variant ID Type Subtype PubMed ID
nsv596234 CNV gain 21841781
nsv480020 CNV novel sequence insertion 20440878
nsv479066 CNV novel sequence insertion 20440878
esv2728766 CNV deletion 23290073
esv2123340 CNV deletion 18987734

Variation tolerance for FBXO8 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO8 Gene

Disorders for FBXO8 Gene

Relevant External Links for FBXO8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO8 Gene

Publications for FBXO8 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for FBXO8 Gene

Sources for FBXO8 Gene

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