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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO7 Gene

protein-coding   GIFtS: 52
GCID: GC22P032870

F-box protein 7

(Previous name: F-box only protein 7 )
 Explore 17 diseases affiliated with
FBXO7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FBXO7    

Aliases
for FBXO7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
F-Box Protein 71 2     FBX2 5
FBX71 2 3 5     PKPS2 5
PARK151 2 5     Fbx1
F-Box Only Protein 71 2     FBX072

External Ids:    HGNC: 135861   Entrez Gene: 257932   Ensembl: ENSG000001002257   OMIM: 6056485   UniProtKB: Q9Y3I13   

Export aliases for FBXO7 gene to outside databases

Previous GC identifers: GC22P029566 GC22P031195 GC22P015827


Summaries
for FBXO7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FBXO7:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs
class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene
have been identified with the full-length natures of only some variants being determined. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: FBX7_HUMAN, Q9Y3I1
Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5

Gene Wiki entry for FBXO7


Genomic Views
for FBXO7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO7 gene promoter:
         GATA-3   Olf-1   CUTL1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBXO7 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12-q13   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q11.2-qter

FBXO7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO7 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P032870:  view genomic region     (about GC identifiers)

Start:
 32,870,663 bp from pter      End:
 32,894,818 bp from pter
Size:
 24,156 bases      Orientation:
 plus strand

Proteins
for FBXO7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FBX7_HUMAN, Q9Y3I1 (See protein sequence)
Recommended Name: F-box only protein 7  
Size: 522 amino acids; 58503 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1
and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and
promotes its interaction with D-type cyclin
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAF04471.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DNB3 B4DWX5 Q5TGC4 Q5TI86 Q96HM6 Q9UF21 Q9UKT2
Alternative splicing: 3 isoforms:  Q9Y3I1-1   Q9Y3I1-2   Q9Y3I1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO7: NX_Q9Y3I1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y3I1

    • FBXO7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028196.1  NP_001244919.1  NP_036311.3  

    ENSEMBL proteins: 
     ENSP00000266087   ENSP00000406155   ENSP00000395823   ENSP00000388547   ENSP00000380571  
     ENSP00000404388   ENSP00000371490  

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    Uscn Proteins for FBXO7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS10531035
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043234protein complex IDA--


    FBXO7 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FBXO7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FBXO7 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001810 F-box_dom_cyclin-like
     IPR021625 Inhibitor_PI31

    Graphical View of Domain Structure for InterPro Entry Q9Y3I1

    ProtoNet protein and cluster: Q9Y3I1

    UniProtKB/Swiss-Prot: FBX7_HUMAN, Q9Y3I1
    Similarity: Contains 1 F-box domain


    Function
    for FBXO7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FBX7_HUMAN, Q9Y3I1
    Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding IPI--


    FBXO7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FBXO7:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fbxo7):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 

    FBXO7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FBXO7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: FBX7_HUMAN, Q9Y3I1
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXO7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/21 Interacting proteins for FBXO7 (Q9Y3I11, 2, 3 ENSP000002660874) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 3, ENSP000002314874EBI-1161222,EBI-307486 I2D: score=6 STRING: ENSP00000231487
    CUL1Q136163, ENSP000003268044I2D: score=4 STRING: ENSP00000326804
    RBBP6Q7Z6E93, ENSP000003178724I2D: score=2 STRING: ENSP00000317872
    DLGAP5Q153983, ENSP000002471914I2D: score=1 STRING: ENSP00000247191
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS10531035
    GO:0008219cell death IEA--
    GO:0016567protein ubiquitination ----
    GO:0031647regulation of protein stability IDA15145941


    FBXO7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FBXO7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO7
    Search CenterWatch for drugs/clinical trials and news about FBXO7 / FBX7 

    Transcripts
    for FBXO7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FBXO7 gene (3 alternative transcripts): 
    NM_001033024.1  NM_001257990.1  NM_012179.3  

    Unigene Cluster for FBXO7:

    F-box protein 7
    Hs.5912  [show with all ESTs]
    Unigene Representative Sequence: AK054739
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266087(uc003amq.3) ENST00000420700 ENST00000425028 ENST00000492535(uc003amp.1 uc003amv.3)
    ENST00000452138 ENST00000397426(uc003amu.3) ENST00000444207 ENST00000465418
    ENST00000484607 ENST00000382058(uc003amt.3)

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF129537.1 AF233225.1 AK054739.1 AK226087.1 AK291972.1 AK297841.1 AK301716.1 AL050254.1 
    BC008361.1 CR456491.1 DQ655988.2 DQ655989.2 DQ655990.2 

    24/37 DOTS entries (see all 37):

    DT.40276194  DT.100865003  DT.95341739  DT.100803679  DT.100653761  DT.95252313  DT.97862901  DT.100862372 
    DT.92469537  DT.100842986  DT.100862896  DT.120635006  DT.40225298  DT.92469482  DT.100653759  DT.95341863 
    DT.100638649  DT.95253953  DT.100645063  DT.100767149  DT.100852230  DT.120634965  DT.120634969  DT.100686937 

    24/773 AceView cDNA sequences (see all 773):

    BM792258 AV726304 CR456491 BQ029380 AA127064 AA429862 BM662010 CR617506 
    BE044637 BX362053 AA176961 CR595323 AA346450 AA781668 AI633400 CR625215 
    AI151013 BQ718090 AA358426 BG939154 CD674068 F01557 AW189287 AA382962 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO7 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11
    SP1:                          -     -     -     -     -                                               -                                       
    SP2:                                                  -                                               -                                       
    SP3:                                                  -     -     -                                   -                                       
    SP4:                                                                                                  -     -     -                           
    SP5:                                                  -     -     -     -     -     -     -           -                                       


    ECgene alternative splicing isoforms for FBXO7

    Expression
    for FBXO7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATTGATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FBXO7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO7

    SOURCE GeneReport for Unigene cluster: Hs.5912
        SABiosciences Expression via Pathway-Focused PCR Array including FBXO7: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for FBXO7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FBXO7 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fbxo71 , 5 F-box protein 71, 5 79.65(n)1
    73.32(a)1    		   10 (41.91 cM)5
    697541  NM_153195.21  NP_694875.21 
     860219725 
    chicken
    (Gallus gallus)    		 Aves FBXO71 F-box protein 7 69.29(n)
    64.23(a)    		   418063  NM_001012537.2  NP_001012555.2 
    lizard
    (Anolis carolinensis)    		 Reptilia FBXO76
    		 --
    		 61(a)
    		 1 ↔ 1
    		 5(19933485-19950024)
    zebrafish
    (Danio rerio)    		 Actinopterygii fbxo71 F-box protein 7 50.64(n)
    44.28(a)    		   558097  NM_001025499.1  NP_001020670.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G703606
    AT1G237706
    (see all 3)    		 F-box domain-containing protein
    (see all 3)    		 22(a)
    20(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 1(26508778-26509325)
    1(8405214-8406266)


    ENSEMBL Gene Tree for FBXO7 (if available)
    TreeFam Gene Tree for FBXO7 (if available) 

    Paralogs
    for FBXO7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for FBXO7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/566 NCBI SNPs in FBXO7 are shown (see all 566)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs717991101,2
    		C,F,pathogenic32889256(+) ATCTGC/G/TGTGAT 9 R G C mis13CA NA 6150
    rs2019740721,2
    		C,--32868852(+) ATAAT-/AATAA 
                AATAA     		1 -- us2k10--------
    rs2006054661,2
    		C,--32868855(+) ATAAT-/AAAATAA 1 -- us2k10--------
    rs96069601,2
    		C,A,--32869011(+) GATCAC/TGCCAC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs2021369381,2
    		--32869056(+) TCTCA-/AACAACAA 1 -- us2k10--------
    rs59985101,2
    		C,A,--32869073(+) AACAAA/CAAAAA 1 -- us2k12Minor allele frequency- C:0.28NA 122
    rs1825742301,2
    		--32869155(+) TGTTCC/GGTGTA 1 -- us2k10--------
    rs1164117201,2
    		C,--32869183(+) CTGGCA/GAGTAT 1 -- us2k10--------
    rs59985111,2
    		C,F,H,--32869211(+) taaaaA/Gtggcc 1 -- us2k17Minor allele frequency- G:0.09NS WA 1062
    rs1927887871,2
    		--32869484(+) GGCAGG/TATGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXO7 (32870663 - 32894818 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FBXO7: --
    Human Gene Mutation Database (HGMD): FBXO7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO7
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO7

    Disorders / Diseases
    for FBXO7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FBXO7 for disorders           About GeneDecksing

    OMIM gene information: 605648   
    OMIM disorders: 260300  
    UniProtKB/Swiss-Prot: FBX7_HUMAN, Q9Y3I1
  • Defects in FBXO7 are the cause of Parkinson disease type 15 (PARK15) [MIM:260300]; also known as
    • parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs.
    Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower
    limbs, and hyperreflexia

    17 diseases for FBXO7:    About MalaCards
    parkinson disease 15, autosomal recessive    fuchs' endothelial dystrophy    irregular astigmatism    vertebrobasilar insufficiency
    panophthalmitis    corneal edema    parkinson's disease    amblyopia
    hematopoiesis    astigmatism    keratopathy    tremor
    keratoconus    keratitis    spasticity    hepatocellular carcinoma
    carcinoma

    7 diseases from the University of Copenhagen DISEASES database for FBXO7:
    Corneal edema     Keratoconus     Keratopathy     Panophthalmitis
    Keratitis     Irregular astigmatism     Corneal dystrophy
    Human Genome Epidemiology (HuGE) Navigator: FBXO7 (1 document)

    Export disorders for FBXO7 gene to outside databases

    Publications
    for FBXO7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO7 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with FBXO7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B- phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. (PubMed id 15145941)1, 2, 9 Hsu J.-M.... Huang C.-Y.F. (2004)
    3. FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome. (PubMed id 19038853)1, 3 Di Fonzo A....Bonifati V. (2008)
    4. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. (PubMed id 16510124)1, 2 Chang Y.F.... Yuo C.Y. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. (PubMed id 12527899)1, 2 Tsou A.-P.... Chou C.-K. (2003)
    9. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)
    10. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)

    External Searches for FBXO7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FBXO7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25793 HGNC: 13586 AceView: FBXO7 Ensembl:ENSG00000100225 euGenes: HUgn25793
    ECgene: FBXO7 H-InvDB: FBXO7

    Other Databases showing FBXO7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FBXO7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FBXO7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FBXO7 gene:
    Search GeneIP for patents involving FBXO7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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