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FBXO6 Gene(Protein Coding)

F-Box Protein 6

GCID:
GC01P011664
GIFtS:
50
Genes Participants
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Aliases for FBXO6 Gene

Aliases for FBXO6 Gene

  • F-Box Protein 6 2 3 5
  • F-Box Protein That Recognizes Sugar Chains 2 3 4
  • F-Box/G-Domain Protein 2 3 4
  • F-Box Only Protein 6 2 3
  • FBG2 3 4
  • FBS2 3 4
  • FBX6 3 4
  • F-Box Protein FBG2 3
  • F-Box Protein Fbx6 3
  • Fbx6b 3

External Ids for FBXO6 Gene

Previous GeneCards Identifiers for FBXO6 Gene

  • GC01P011685
  • GC01P011567
  • GC01P011333
  • GC01P011433
  • GC01P011658
  • GC01P011724
  • GC01P010879

Summaries for FBXO6 Gene

Entrez Gene Summary for FBXO6 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO6 Gene

FBXO6 (F-Box Protein 6) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System. GO annotations related to this gene include ubiquitin-protein transferase activity and glycoprotein binding. An important paralog of this gene is FBXO2.

UniProtKB/Swiss-Prot for FBXO6 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on Ser-345), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Gene Wiki entry for FBXO6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO6 Gene

Genomics for FBXO6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBXO6 Gene

Enhancers for FBXO6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G011676 1.1 dbSUPER 13.6 +13.0 12973 1.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 FOS FBXO6 PIR43631 DRAXIN
GH01G011663 1 ENCODE 14.7 +0.4 432 1.8 HDGF ATF1 AGO1 SIN3A ARID4B ZNF48 CBX5 ZNF143 REST ZNF592 FBXO6 FBXO44 MIIP PIR43631
GH01G011680 1.4 ENCODE dbSUPER 8.4 +17.9 17880 3.4 AGO1 ARID4B SIN3A YY1 ZNF143 KLF13 SP3 SP5 REST ZNF592 MAD2L2 FBXO6 DRAXIN PIR43631
GH01G011670 1.1 ENCODE 8.8 +7.3 7330 2.4 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B YY1 ZNF766 KLF13 SP5 MAD2L2 DRAXIN FBXO6 PIR43631
GH01G011978 2 FANTOM5 Ensembl ENCODE dbSUPER 3.2 +318.6 318639 8.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 ZNF143 MCM3 SP3 MFN2 MIIP TNFRSF1B PLOD1 KIAA2013 RNU5E-4P RNU5E-1 NPPB EXOSC10 MTHFR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO6 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000001419 507 1201 HDGF ATF1 AGO1 SIN3A ARID4B ZNF48 CBX5 ZNF143 REST ZNF592

Transcription factor binding sites by QIAGEN in the FBXO6 gene promoter:

Genomic Location for FBXO6 Gene

Chromosome:
1
Start:
11,664,093 bp from pter
End:
11,674,354 bp from pter
Size:
10,262 bases
Orientation:
Plus strand

Genomic View for FBXO6 Gene

Genes around FBXO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO6 Gene

Proteins for FBXO6 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for FBXO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD1-FBX6_HUMAN
    Recommended name:
    F-box only protein 6
    Protein Accession:
    Q9NRD1
    Secondary Accessions:
    • B1AK42
    • B2RC88
    • Q9UKT3

    Protein attributes for FBXO6 Gene

    Size:
    293 amino acids
    Molecular mass:
    33933 Da
    Quaternary structure:
    • Interacts with VCP (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with CHEK1 and CUL1.
    SequenceCaution:
    • Sequence=AAF04470.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20215.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FBXO6 Gene

Protein Expression for FBXO6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO6 Gene

Domains & Families for FBXO6 Gene

Gene Families for FBXO6 Gene

HGNC:

Protein Domains for FBXO6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO6: view

No data available for UniProtKB/Swiss-Prot for FBXO6 Gene

Function for FBXO6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBXO6 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on Ser-345), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Gene Ontology (GO) - Molecular Function for FBXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA,ISS --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 19716789
GO:0030246 carbohydrate binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with FBXO6: view
genes like me logo Genes that share phenotypes with FBXO6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO6 Gene

Localization for FBXO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO6 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19716789
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 19716789
GO:0044322 endoplasmic reticulum quality control compartment IEA --
genes like me logo Genes that share ontologies with FBXO6: view

Pathways & Interactions for FBXO6 Gene

genes like me logo Genes that share pathways with FBXO6: view

UniProtKB/Swiss-Prot Q9NRD1-FBX6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint TAS 19716789
GO:0000209 protein polyubiquitination TAS --
GO:0006281 DNA repair TAS 19716789
GO:0006508 proteolysis TAS 10531035
GO:0006516 glycoprotein catabolic process IEA --
genes like me logo Genes that share ontologies with FBXO6: view

No data available for SIGNOR curated interactions for FBXO6 Gene

Drugs & Compounds for FBXO6 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for FBXO6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBXO6 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(49) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO6 Gene

F-box protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO6 Gene

No ASD Table

Relevant External Links for FBXO6 Gene

GeneLoc Exon Structure for
FBXO6
ECgene alternative splicing isoforms for
FBXO6

Expression for FBXO6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO6 Gene

mRNA expression in normal human tissues for FBXO6 Gene
mRNA expression by GTEx for FBXO6 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO6 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for FBXO6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.0), NK cells (9.5), and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO6 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXO6 Gene:

FBXO6

SOURCE GeneReport for Unigene cluster for FBXO6 Gene:

Hs.464419

Evidence on tissue expression from TISSUES for FBXO6 Gene

  • Kidney(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with FBXO6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO6 Gene

Orthologs for FBXO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBXO6 34 35
  • 99.43 (n)
cow
(Bos Taurus)
 Mammalia FBXO6 34 35
  • 84.97 (n)
dog
(Canis familiaris)
 Mammalia FBXO6 34 35
  • 84.4 (n)
rat
(Rattus norvegicus)
 Mammalia Fbxo6 34
  • 79.72 (n)
mouse
(Mus musculus)
 Mammalia Fbxo6 34 16 35
  • 78.75 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 66 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 62 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves FBXO6 34
  • 63.4 (n)
-- 35
  • 55 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 48 (a)
 ManyToMany
-- 35
  • 36 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo6 34
  • 54.39 (n)
zebrafish
(Danio rerio)
 Actinopterygii zgc:173570 34 35
  • 50.2 (n)
zgc:175088 35
  • 44 (a)
 ManyToMany
zgc:100832 35
  • 42 (a)
 ManyToMany
zgc:153722 35
  • 38 (a)
 ManyToMany
fbxo44 35
  • 36 (a)
 ManyToMany
si:rp71-1k13.6 35
  • 35 (a)
 ManyToMany
zgc:114174 35
  • 32 (a)
 ManyToMany
zgc:114081 35
  • 31 (a)
 ManyToMany
si:dkey-147f3.4 35 35
  • 28 (a)
 ManyToMany
si:dkey-147f3.8 35
  • 23 (a)
 ManyToMany
Species where no ortholog for FBXO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO6 Gene

ENSEMBL:
Gene Tree for FBXO6 (if available)
TreeFam:
Gene Tree for FBXO6 (if available)

Paralogs for FBXO6 Gene

Paralogs for FBXO6 Gene

(3) SIMAP similar genes for FBXO6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXO6: view

Variants for FBXO6 Gene

Sequence variations from dbSNP and Humsavar for FBXO6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000097533 -- 11,663,779(+) GCCTC(C/T)GGAGG downstream-variant-500B, upstream-variant-2KB
rs1000360701 -- 11,673,952(+) CCCCG(C/G)TTCAA utr-variant-3-prime
rs1000531437 -- 11,664,097(+) AAGGA(A/G)CTAGT upstream-variant-2KB, utr-variant-5-prime
rs1001269221 -- 11,663,455(+) AGGAT(-/CAC)CACCC downstream-variant-500B, upstream-variant-2KB
rs1001430674 -- 11,668,274(+) TAAAA(A/C)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO6 Gene

Variant ID Type Subtype PubMed ID
esv3585225 CNV loss 21293372
nsv545416 CNV loss 21841781
nsv832758 CNV loss 17160897

Variation tolerance for FBXO6 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO6 Gene

Disorders for FBXO6 Gene

Relevant External Links for FBXO6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO6

No disorders were found for FBXO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO6 Gene

Publications for FBXO6 Gene

  1. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PMID: 10945468) Ilyin G.P. … Guguen-Guillouzo C. (Genomics 2000) 2 3 4 22 64
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 4 22 64
  3. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  4. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. (PMID: 19716789) Zhang Y.-W. … Hunter T. (Mol. Cell 2009) 3 4 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

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Sources for FBXO6 Gene

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