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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO6 Gene

protein-coding   GIFtS: 53
GCID: GC01P011724

F-box protein 6

(Previous name: F-box only protein 6 )
 Explore 1 disease affiliated with
FBXO6 via our new
 Human Malady Compendium 
Biological research products
for FBXO6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
F-Box Protein 61 2     F-Box Only Protein 61 2
FBG21 2 3 5     F-Box Protein That Recognizes Sugar Chains 22 3
FBX61 2 3 5     F-Box/G-Domain Protein 22 3
FBS21 2 3     F-Box Protein FBG22
Fbx6b1 2     F-Box Protein Fbx62

External Ids:    HGNC: 135851   Entrez Gene: 262702   Ensembl: ENSG000001166637   OMIM: 6056475   UniProtKB: Q9NRD13   

Export aliases for FBXO6 gene to outside databases

Previous GC identifers: GC01P011685 GC01P011567 GC01P011333 GC01P011433 GC01P011658 GC01P010879


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO6:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs
class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in
the control of the cell cycle. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1
Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes.
Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing
and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their
ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with
not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA
damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its
ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate
as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA
replication

Gene Wiki entry for FBXO6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO6 gene promoter:
         Max1   Elk-1   Olf-1   Pax-2   AP-4   Pax-2a   Nkx2-5   PPAR-alpha   Pax-3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

FBXO6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P011724:  view genomic region     (about GC identifiers)

Start:
11,724,150 bp from pter      End:
11,734,411 bp from pter
Size:
10,262 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1 (See protein sequence)
Recommended Name: F-box only protein 6  
Size: 293 amino acids; 33933 Da
Subunit: Interacts with VCP (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with
CHEK1 and CUL1
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAF04470.1; Type=Erroneous initiation; Sequence=CAI20215.1; Type=Erroneous gene model
prediction;
Secondary accessions: B1AK42 B2RC88 Q9UKT3

Explore the universe of human proteins at neXtProt for FBXO6: NX_Q9NRD1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRD1

  • FBXO6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060908.1  
    ENSEMBL proteins: 
     ENSP00000365944   ENSP00000388781  
    Reactome Protein details: Q9NRD1
    Human Recombinant Protein Products: 
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    Novus Biologicals FBXO6 Protein
    Novus Biologicals FBXO6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FBXO6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19716789
    GO:0019005SCF ubiquitin ligase complex IDA19716789


    FBXO6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FBXO6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007397 F-box-assoc_dom
     IPR008979 Galactose-bd-like
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9NRD1

    ProtoNet protein and cluster: Q9NRD1

    1 Blocks protein family: IPB007397 F-box associated region

    UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 FBA (F-box associated) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1
    Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes.
    Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing
    and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their
    ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with
    not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA
    damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its
    ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate
    as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA
    replication

    miRNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding ISS--
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI19716789
    GO:0030246carbohydrate binding IEA--


    FBXO6 for ontologies           About GeneDecksing


    11 GenomeRNAi human phenotypes for FBXO6:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased cilium length after   Increased G1 DNA content 
     Increased cell death HMECs cel  Increased cell size  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Polyubiquitination of substrate0.75
    Class I MHC mediated antigen processing & presentation0.83
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding1.00
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Immune System
    Immune System1.00
    Adaptive Immune System0.59
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum1.00
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/9        Reactome Pathways for FBXO6 (see all 9)
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Antigen processing: Ubiquitination & Proteasome degradation
    Metabolism of proteins
    Polyubiquitination of substrate


    1         Kegg Pathway  (Kegg details for FBXO6):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1
    Pathway: Protein modification; protein ubiquitination


    FBXO6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for FBXO6 (Q9NRD12, 3 ENSP000003659444) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136162, 3, ENSP000003268044MINT-8399502 I2D: score=1 STRING: ENSP00000326804
    RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    SKP1P632083, ENSP000002314874I2D: score=3 STRING: ENSP00000231487
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint TAS19716789
    GO:0006281DNA repair TAS19716789
    GO:0006508proteolysis TAS10531035
    GO:0006516glycoprotein catabolic process IEA--
    GO:0006986response to unfolded protein IEA--


    FBXO6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO6
    Search CenterWatch for drugs/clinical trials and news about FBXO6 / FBX6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO6 gene: 
    NM_018438.5  

    Unigene Cluster for FBXO6:

    F-box protein 6
    Hs.464419  [show with all ESTs]
    Unigene Representative Sequence: NM_018438
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376753(uc001aso.3) ENST00000474239 ENST00000449067

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    hsa-miR-3116 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFBXO6 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO6

    Additional cDNA sequence: 

    AF129536.1 AF233223.1 AK314989.1 BC020880.1 

    3 DOTS entries:

    DT.108367  DT.121407587  DT.97763652 

    24/49 AceView cDNA sequences (see all 49):

    BQ185942 BE384888 BU521777 BU631452 BQ019301 BQ679204 AF233223 BU616015 
    BC020880 AW070815 BI160729 AI341548 BU185709 BX400452 BG339115 CA423571 
    AA167629 CA423504 BQ184245 CD364787 NM_018438 BM564022 AI984856 BU149504 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGTGGGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FBXO6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO6

    SOURCE GeneReport for Unigene cluster: Hs.464419
        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO6: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO6 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FBXO61 F-box protein 6 64.66(n)
    59.84(a)
      419494  XM_417649.3  XP_417649.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    56(a)
    37(a)
    many ↔ many
    many ↔ many
    AAWZ02039643(2317-7689)
    GL343881.1(121545-128618)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1735701 zgc:173570 50.2(n)
    44.58(a)
      570101  NM_001111202.1  NP_001104672.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    30(a)
    1 → many
    GroupUn.464(7518-8665)


    ENSEMBL Gene Tree for FBXO6 (if available)
    TreeFam Gene Tree for FBXO6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO6 gene
    FBXO272  FBXO442  FBXO22  NCCRP12  
    4 SIMAP similar genes for FBXO6 using alignment to 2 protein entries:     FBX6_HUMAN (see all proteins):
    FBXO44    FBXO2    FBXO27    FBXO17

    FBXO6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 NCBI SNPs in FBXO6 are shown (see all 268    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875304721,2
    --11722202(+) CCCCAC/TCCCAC 5 -- ut31 us2k10--------
    rs1921140651,2
    --11722588(+) GGGGTG/TTGTGG 5 -- us2k1 ut310--------
    rs1428163101,2
    --11722687(+) CTTTAC/TGGACA 5 -- ut31 us2k10--------
    rs31258151,2
    C,F,A,H,--11722688(-) ATGTCC/TGTAAA 5 -- us2k1 ut3120Minor allele frequency- T:0.14NS EA NA WA 2526
    rs1461507051,2
    --11722742(+) GGTGCA/GTGATA 5 -- us2k1 ut310--------
    rs1401612221,2
    --11722843(+) GGGAGC/TGGTTT 5 -- ut31 us2k10--------
    rs1851237741,2
    --11722952(+) AAGGTC/TGTTGC 5 -- ut31 us2k10--------
    rs1147779771,2
    --11722981(+) CACCAT/CGATTG 5 -- us2k1 ut311Minor allele frequency- C:0.01NA 120
    rs716470051,2
    C,F--11723015(+) TCTTTC/TTTTTT 5 -- us2k1 ut313Minor allele frequency- T:0.50NA 6
    rs1880645221,2
    --11723234(+) GTGGTC/TTCAAT 5 -- us2k1 ut310--------

    HapMap Linkage Disequilibrium report for FBXO6 (11724150 - 11734411 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FBXO6: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FBXO6 for disorders           About GeneDecksing

    OMIM gene information: 605647    OMIM disorders: --

    1 disease for FBXO6:    About MalaCards
    gastric cancer


    Export disorders for FBXO6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO6 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with FBXO6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2, 3, 9 Ilyin G.P.... Guguen-Guillouzo C. (2000)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    3. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2, 9 Glenn K.A.... Paulson H.L. (2008)
    4. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. (PubMed id 19716789)1, 2 Zhang Y.-W.... Hunter T. (2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 9 Ilyin G.P....Guguen-Guillouzo C. (2002)
    8. SPPS: a sequence-based method for predicting probabili ty of protein-protein interaction partners. (PubMed id 22292078)1 Liu X....Zhang J. (2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    10. Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26270 HGNC: 13585 AceView: FBXO6 Ensembl:ENSG00000116663 euGenes: HUgn26270
    ECgene: FBXO6 Kegg: 26270 H-InvDB: FBXO6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO6 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_821

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO6 gene:
    Search GeneIP for patents involving FBXO6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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