FBXO6 Gene
protein-coding GIFtS: 53
GCID: GC01P011724
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F-box protein 6(Previous name: F-box only protein 6 )
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Aliases for FBXO6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| F-Box Protein 61 2 | | F-Box Only Protein 61 2 | | FBG21 2 3 5 | | F-Box Protein That Recognizes Sugar Chains 22 3 | | FBX61 2 3 5 | | F-Box/G-Domain Protein 22 3 | | FBS21 2 3 | | F-Box Protein FBG22 | | Fbx6b1 2 | | F-Box Protein Fbx62 |
Export aliases for FBXO6 gene to outside databasesPrevious GC identifers: GC01P011685 GC01P011567 GC01P011333 GC01P011433 GC01P011658 GC01P010879 |
Summaries for FBXO6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for FBXO6: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxsclass, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved inthe control of the cell cycle. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes.Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizingand binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting theirubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified withnot only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNAdamage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting itsubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulateas cells progress through S phase, or when replication forks encounter transient impediments during normal DNAreplication Gene Wiki entry for FBXO6
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Genomic Views for FBXO6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXO6 gene promoter: Max1 Elk-1 Olf-1 Pax-2 AP-4 Pax-2a Nkx2-5 PPAR-alpha Pax-3 ARP-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO6 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22FBXO6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P011724: view genomic region
(about GC identifiers)
Start:
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11,724,150 bp from pter |
End:
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11,734,411 bp from pter |
Size:
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10,262 bases |
Orientation:
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plus strand |
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Proteins for FBXO6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1 (See
protein sequence)Recommended Name: F-box only protein 6 Size: 293 amino acids; 33933 Da
Subunit: Interacts with VCP (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts withCHEK1 and CUL1
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAF04470.1; Type=Erroneous initiation; Sequence=CAI20215.1; Type=Erroneous gene modelprediction;
Secondary accessions: B1AK42 B2RC88 Q9UKT3Explore the universe of human proteins at neXtProt for FBXO6: NX_Q9NRD1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRD1 FBXO6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060908.1 ENSEMBL proteins: ENSP00000365944 ENSP00000388781 Reactome Protein details: Q9NRD1 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FBXO6 for ontologies About GeneDecksing
FBXO6 Antibody Products: Assay Products for FBXO6: |
Protein
Domains / Families for FBXO6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRD1ProtoNet protein and cluster: Q9NRD1 1 Blocks protein family: IPB007397 F-box associated region
UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1Similarity: Contains 1 F-box domainSimilarity: Contains 1 FBA (F-box associated) domain |
Function for FBXO6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes.Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizingand binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting theirubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified withnot only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNAdamage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting itsubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulateas cells progress through S phase, or when replication forks encounter transient impediments during normal DNAreplication
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO6 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO6 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXO6 (NM_018438) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO6  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO6 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
FBXO6 for ontologies About GeneDecksing
11 GenomeRNAi human phenotypes for FBXO6:
|
Pathways & Interactions for FBXO6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Chaperonin-mediated protein folding | | | 3 | Immune System | | | 4 | Protein processing in endoplasmic reticulum | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
5/9
Reactome Pathways for FBXO6 (see all 9)
1
Kegg Pathway (Kegg details for FBXO6): UniProtKB/Swiss-Prot: FBX6_HUMAN, Q9NRD1Pathway: Protein modification; protein ubiquitination
FBXO6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/28 Interacting proteins for FBXO6 (Q9NRD12, 3 ENSP000003659444) via UniProtKB, MINT, STRING, and/or I2D (see all 28) About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
FBXO6 for ontologies About GeneDecksing
|
Drugs & Compounds for FBXO6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FBXO6 Search CenterWatch for drugs/clinical trials and news about FBXO6 / FBX6 
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Transcripts for FBXO6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FBXO6 gene: NM_018438.5 Unigene Cluster for FBXO6: F-box protein 6 Hs.464419 [show with all ESTs]Unigene Representative Sequence: NM_0184383 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376753(uc001aso.3) ENST00000474239 ENST00000449067
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO6 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO6 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXO6 (NM_018438) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO6  |
Additional cDNA sequence: AF129536.1 AF233223.1 AK314989.1 BC020880.1 3 DOTS entries: DT.108367 DT.121407587 DT.97763652 24/49 AceView cDNA sequences (see all 49): BQ185942 BE384888 BU521777 BU631452 BQ019301 BQ679204 AF233223 BU616015 BC020880 AW070815 BI160729 AI341548 BU185709 BX400452 BG339115 CA423571 AA167629 CA423504 BQ184245 CD364787 NM_018438 BM564022 AI984856 BU149504 GeneLoc Exon Structure
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Expression for FBXO6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGGTGGGCAG
About this image See FBXO6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBXO6
SOURCE GeneReport for Unigene cluster: Hs.464419 SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO6:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO6 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO6 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO6 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO6 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO6 |
Orthologs for FBXO6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXO6 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for FBXO6 (if available) TreeFam Gene Tree for FBXO6 (if available)  |
Paralogs for FBXO6 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FBXO6 gene
- FBXO272 FBXO442 FBXO22 NCCRP12
4 SIMAP similar genes for FBXO6 using alignment to 2 protein entries: FBX6_HUMAN (see all proteins):FBXO44 FBXO2 FBXO27 FBXO17
FBXO6 for paralogs About GeneDecksing
|
Genomic Variants for FBXO6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXO6 (11724150 - 11734411 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FBXO6: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO6 |
|
Disorders
/ Diseases for FBXO6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXO6 for disorders About GeneDecksing
OMIM gene information: 605647
OMIM disorders: --
1 disease for FBXO6: About MalaCardsgastric cancer Export disorders for FBXO6 gene to outside databases
|
Publications for FBXO6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO6 gene, integrated from 9 sources (see all 23): (articles sorted by number of sources associating them with FBXO6) | |  | Utopia: connect your pdf to the dynamic world of online information |
- cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2, 3, 9 Ilyin G.P.... Guguen-Guillouzo C. (2000)
- Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2, 9 Glenn K.A.... Paulson H.L. (2008)
- The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. (PubMed id 19716789)1, 2 Zhang Y.-W.... Hunter T. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 9 Ilyin G.P....Guguen-Guillouzo C. (2002)
- SPPS: a sequence-based method for predicting probabili ty of protein-protein interaction partners. (PubMed id 22292078)1 Liu X....Zhang J. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
|
External Searches for FBXO6 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FBXO6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXO6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FBXO6 | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_821 |
|
| | |
About This Section
| Patent Information for FBXO6 gene: Search GeneIP for patents involving FBXO6
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FBXO6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | Search Tocris compounds for FBXO6 |
| |  |  |  |  | | | | |
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 | | FBXO6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO6 |
|  |  |  | | | ThermoFisher Antibodies for FBXO6 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO6 |
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