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Aliases for FBXO6 Gene

Aliases for FBXO6 Gene

  • F-Box Protein 6 2 3
  • FBG2 3 4 6
  • FBX6 3 4 6
  • F-Box Protein That Recognizes Sugar Chains 2 3 4
  • F-Box/G-Domain Protein 2 3 4
  • F-Box Only Protein 6 2 3
  • FBS2 3 4
  • F-Box Protein FBG2 3
  • F-Box Protein Fbx6 3
  • Fbx6b 3

External Ids for FBXO6 Gene

Summaries for FBXO6 Gene

Entrez Gene Summary for FBXO6 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO6 Gene

FBXO6 (F-Box Protein 6) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include ubiquitin-protein transferase activity and glycoprotein binding. An important paralog of this gene is NCCRP1.

UniProtKB/Swiss-Prot for FBXO6 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on Ser-345), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Gene Wiki entry for FBXO6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO6 Gene

Genomics for FBXO6 Gene

Genomic Location for FBXO6 Gene

Start:
11,664,093 bp from pter
End:
11,674,354 bp from pter
Size:
10,262 bases
Orientation:
Plus strand

Genomic View for FBXO6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO6 Gene

Regulatory Elements for FBXO6 Gene

Proteins for FBXO6 Gene

  • Protein details for FBXO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD1-FBX6_HUMAN
    Recommended name:
    F-box only protein 6
    Protein Accession:
    Q9NRD1
    Secondary Accessions:
    • B1AK42
    • B2RC88
    • Q9UKT3

    Protein attributes for FBXO6 Gene

    Size:
    293 amino acids
    Molecular mass:
    33933 Da
    Quaternary structure:
    • Interacts with VCP (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with CHEK1 and CUL1.
    SequenceCaution:
    • Sequence=AAF04470.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20215.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FBXO6 Gene

Proteomics data for FBXO6 Gene at MOPED

Post-translational modifications for FBXO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO6 Gene

Domains for FBXO6 Gene

Gene Families for FBXO6 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO6 Gene

Suggested Antigen Peptide Sequences for FBXO6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRD1

UniProtKB/Swiss-Prot:

FBX6_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q9NRD1
  • Contains 1 FBA (F-box associated) domain.:
    • Q9NRD1
genes like me logo Genes that share domains with FBXO6: view

Function for FBXO6 Gene

Molecular function for FBXO6 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on Ser-345), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Gene Ontology (GO) - Molecular Function for FBXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding ISS --
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 19716789
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with FBXO6: view
genes like me logo Genes that share phenotypes with FBXO6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO6 Gene

Localization for FBXO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO6 Gene COMPARTMENTS Subcellular localization image for FBXO6 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19716789
GO:0019005 SCF ubiquitin ligase complex IDA 19716789
genes like me logo Genes that share ontologies with FBXO6: view

Pathways for FBXO6 Gene

genes like me logo Genes that share pathways with FBXO6: view

UniProtKB/Swiss-Prot Q9NRD1-FBX6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint TAS 19716789
GO:0006281 DNA repair TAS 19716789
GO:0006508 proteolysis TAS 10531035
GO:0006516 glycoprotein catabolic process IEA --
GO:0006986 response to unfolded protein IEA --
genes like me logo Genes that share ontologies with FBXO6: view

Transcripts for FBXO6 Gene

Unigene Clusters for FBXO6 Gene

F-box protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO6 Gene

No ASD Table

Relevant External Links for FBXO6 Gene

GeneLoc Exon Structure for
FBXO6
ECgene alternative splicing isoforms for
FBXO6

Expression for FBXO6 Gene

mRNA expression in normal human tissues for FBXO6 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO6 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO6 Gene

SOURCE GeneReport for Unigene cluster for FBXO6 Gene Hs.464419

genes like me logo Genes that share expressions with FBXO6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FBXO6 Gene

Orthologs for FBXO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO6 35
  • 99.43 (n)
  • 99.32 (a)
FBXO6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO6 35
  • 84.97 (n)
  • 80.68 (a)
FBXO6 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO6 35
  • 84.4 (n)
  • 80.85 (a)
FBXO6 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo6 35
  • 78.75 (n)
  • 75.19 (a)
Fbxo6 16
Fbxo6 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxo6 35
  • 79.72 (n)
  • 77.95 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 55 (a)
OneToMany
FBXO6 35
  • 63.4 (n)
  • 58.11 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo6 35
  • 54.39 (n)
  • 52.63 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo44 36
  • 36 (a)
ManyToMany
si:dkey-147f3.4 36
  • 28 (a)
ManyToMany
si:dkey-147f3.4 36
  • 35 (a)
ManyToMany
si:dkey-147f3.8 36
  • 23 (a)
ManyToMany
si:rp71-1k13.6 36
  • 35 (a)
ManyToMany
zgc:100832 36
  • 42 (a)
ManyToMany
zgc:114081 36
  • 31 (a)
ManyToMany
zgc:114174 36
  • 32 (a)
ManyToMany
zgc:153722 36
  • 38 (a)
ManyToMany
zgc:173570 35
  • 50.2 (n)
  • 44.58 (a)
zgc:173570 36
  • 39 (a)
ManyToMany
zgc:175088 36
  • 44 (a)
ManyToMany
Species with no ortholog for FBXO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO6 Gene

ENSEMBL:
Gene Tree for FBXO6 (if available)
TreeFam:
Gene Tree for FBXO6 (if available)

Paralogs for FBXO6 Gene

Paralogs for FBXO6 Gene

Selected SIMAP similar genes for FBXO6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXO6: view

Variants for FBXO6 Gene

Sequence variations from dbSNP and Humsavar for FBXO6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs744115 -- 11,671,120(+) CAGCC(A/C/G)CAGAG intron-variant
rs747862 -- 11,673,018(-) CCTCA(A/G)AAATC intron-variant
rs747863 -- 11,672,875(-) GCTCA(A/G)CCCAG intron-variant
rs1076964 -- 11,671,754(-) CCAGT(A/G)CAGGA intron-variant
rs1985120 -- 11,667,863(+) cgagg(C/T)gggcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO6 Gene

Variant ID Type Subtype PubMed ID
nsv832758 CNV Loss 17160897
dgv139n71 CNV Loss 21882294
nsv871014 CNV Gain 21882294
nsv871850 CNV Loss 21882294

Relevant External Links for FBXO6 Gene

HapMap Linkage Disequilibrium report
FBXO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO6 Gene

Disorders for FBXO6 Gene

No disorders were found for FBXO6 Gene.

No data available for UniProtKB/Swiss-Prot for FBXO6 Gene

Publications for FBXO6 Gene

  1. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PMID: 10945468) Ilyin G.P. … Guguen-Guillouzo C. (Genomics 2000) 2 3 4 23
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 4 23
  3. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  4. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 23
  5. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. (PMID: 19716789) Zhang Y.-W. … Hunter T. (Mol. Cell 2009) 3 4

Products for FBXO6 Gene

Sources for FBXO6 Gene

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