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Aliases for FBXO5 Gene

Aliases for FBXO5 Gene

  • F-Box Protein 5 2 3
  • EMI1 3 4 6
  • FBX5 3 4 6
  • Early Mitotic Inhibitor 1 3 4
  • F-Box Only Protein 5 2 3
  • F-Box Protein Fbx5 3
  • Fbxo31 3

External Ids for FBXO5 Gene

Previous GeneCards Identifiers for FBXO5 Gene

  • GC06M152852
  • GC06M153186
  • GC06M153322
  • GC06M153383
  • GC06M153333
  • GC06M153291
  • GC06M150854

Summaries for FBXO5 Gene

Entrez Gene Summary for FBXO5 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

GeneCards Summary for FBXO5 Gene

FBXO5 (F-Box Protein 5) is a Protein Coding gene. Diseases associated with FBXO5 include tetraploidy. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is FBXO43.

UniProtKB/Swiss-Prot for FBXO5 Gene

  • Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

Gene Wiki entry for FBXO5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO5 Gene

Genomics for FBXO5 Gene

Regulatory Elements for FBXO5 Gene

Genomic Location for FBXO5 Gene

152,970,519 bp from pter
152,983,605 bp from pter
13,087 bases
Minus strand

Genomic View for FBXO5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO5 Gene

Proteins for FBXO5 Gene

  • Protein details for FBXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 5
    Protein Accession:
    Secondary Accessions:
    • B3KNX5
    • Q5TF47
    • Q8WV29
    • Q9UGC8

    Protein attributes for FBXO5 Gene

    447 amino acids
    Molecular mass:
    50146 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with BTRC, FZR1/CDH1 and the N-terminal substrate-binding domain of CDC20. Also interacts with EVI5 which blocks its phosphorylation by PLK1 and prevents its subsequent binding to BTRC and degradation.

    Three dimensional structures from OCA and Proteopedia for FBXO5 Gene

    Alternative splice isoforms for FBXO5 Gene


neXtProt entry for FBXO5 Gene

Proteomics data for FBXO5 Gene at MOPED

Post-translational modifications for FBXO5 Gene

  • Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression
  • Ubiquitinated by the by the SCF(BTRC) complex following phosphorylation by PLK1
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO5 Gene

Domains for FBXO5 Gene

Gene Families for FBXO5 Gene

  • FBXO :F-boxes / "other"

Protein Domains for FBXO5 Gene


Suggested Antigen Peptide Sequences for FBXO5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UKT4
  • The C-terminal region is required for inhibition of APC activity
  • Contains 1 F-box domain.
  • Contains 1 IBR-type zinc finger.
genes like me logo Genes that share domains with FBXO5: view

Function for FBXO5 Gene

Molecular function for FBXO5 Gene

UniProtKB/Swiss-Prot Function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

Gene Ontology (GO) - Molecular Function for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11988738
GO:0019901 protein kinase binding IPI 15148369
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FBXO5: view
genes like me logo Genes that share phenotypes with FBXO5: view

Animal Models for FBXO5 Gene

MGI Knock Outs for FBXO5:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FBXO5 Gene

Localization for FBXO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle.

Subcellular locations from

Jensen Localization Image for FBXO5 Gene COMPARTMENTS Subcellular localization image for FBXO5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11988738
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11988738
GO:0005819 spindle IDA 15469984
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO5: view

Pathways for FBXO5 Gene

genes like me logo Genes that share pathways with FBXO5: view

Pathways by source for FBXO5 Gene

1 KEGG pathway for FBXO5 Gene

Gene Ontology (GO) - Biological Process for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001556 oocyte maturation IEA --
GO:0007057 spindle assembly involved in female meiosis I IEA --
genes like me logo Genes that share ontologies with FBXO5: view

Transcripts for FBXO5 Gene

Unigene Clusters for FBXO5 Gene

F-box protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO5 Gene

No ASD Table

Relevant External Links for FBXO5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO5 Gene

mRNA expression in normal human tissues for FBXO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO5 Gene

SOURCE GeneReport for Unigene cluster for FBXO5 Gene Hs.520506

genes like me logo Genes that share expressions with FBXO5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO5 Gene

Orthologs for FBXO5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO5 35
  • 99.78 (n)
  • 99.33 (a)
FBXO5 36
  • 99 (a)
(Bos Taurus)
Mammalia FBXO5 36
  • 81 (a)
(Canis familiaris)
Mammalia FBXO5 35
  • 86.67 (n)
  • 81.35 (a)
FBXO5 36
  • 82 (a)
(Mus musculus)
Mammalia Fbxo5 35
  • 75.69 (n)
  • 67.22 (a)
Fbxo5 16
Fbxo5 36
  • 67 (a)
(Monodelphis domestica)
Mammalia FBXO5 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
-- 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Fbxo5 35
  • 73.78 (n)
  • 65.47 (a)
(Gallus gallus)
Aves FBXO5 35
  • 62.17 (n)
  • 50.38 (a)
FBXO5 36
  • 46 (a)
(Anolis carolinensis)
Reptilia FBXO5 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo5 35
  • 56.31 (n)
  • 45.03 (a)
(Danio rerio)
Actinopterygii fbxo5 35
  • 46.37 (n)
  • 34.71 (a)
fbxo5 36
  • 30 (a)
Species with no ortholog for FBXO5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO5 Gene

Gene Tree for FBXO5 (if available)
Gene Tree for FBXO5 (if available)

Paralogs for FBXO5 Gene

Paralogs for FBXO5 Gene

genes like me logo Genes that share paralogs with FBXO5: view

Variants for FBXO5 Gene

Sequence variations from dbSNP and Humsavar for FBXO5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1712 -- 152,970,730(+) GACAA(C/T)ACATT utr-variant-3-prime
rs1713 -- 152,970,788(+) AGGAA(C/T)ATAAA utr-variant-3-prime
rs1009899 -- 152,977,310(+) GTATA(C/T)AGCAT intron-variant
rs1009900 -- 152,977,371(+) AACCA(C/T)TTTTT intron-variant
rs1997960 -- 152,971,577(+) ATGCA(G/T)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO5 Gene

Variant ID Type Subtype PubMed ID
esv24301 CNV Gain 19812545

Relevant External Links for FBXO5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO5 Gene

Disorders for FBXO5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FBXO5 Gene including...

Search for FBXO5 Gene in MalaCards »

Relevant External Links for FBXO5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FBXO5: view

No data available for UniProtKB/Swiss-Prot for FBXO5 Gene

Publications for FBXO5 Gene

  1. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). (PMID: 11988738) Hsu J.Y. … Jackson P.K. (Nat. Cell Biol. 2002) 3 4 23
  2. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (PMID: 15148369) Moshe Y. … Hershko A. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  3. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  4. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  5. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. (PMID: 16921029) Miller J.J. … Jackson P.K. (Genes Dev. 2006) 3 4

Products for FBXO5 Gene

  • Addgene plasmids for FBXO5

Sources for FBXO5 Gene

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