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Aliases for FBXO5 Gene

Aliases for FBXO5 Gene

  • F-Box Protein 5 2 3 5
  • Early Mitotic Inhibitor 1 3 4
  • EMI1 3 4
  • FBX5 3 4
  • F-Box Only Protein 5 2
  • F-Box Protein Fbx5 3
  • Fbxo31 3

External Ids for FBXO5 Gene

Previous GeneCards Identifiers for FBXO5 Gene

  • GC06M152852
  • GC06M153186
  • GC06M153322
  • GC06M153383
  • GC06M153333
  • GC06M153291
  • GC06M150854

Summaries for FBXO5 Gene

Entrez Gene Summary for FBXO5 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

GeneCards Summary for FBXO5 Gene

FBXO5 (F-Box Protein 5) is a Protein Coding gene. Diseases associated with FBXO5 include tetraploidy. Among its related pathways are Cell Cycle, Mitotic and Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is FBXO43.

UniProtKB/Swiss-Prot for FBXO5 Gene

  • Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

Gene Wiki entry for FBXO5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO5 Gene

Genomics for FBXO5 Gene

Regulatory Elements for FBXO5 Gene

Promoters for FBXO5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO5 Gene

Chromosome:
6
Start:
152,970,519 bp from pter
End:
152,983,605 bp from pter
Size:
13,087 bases
Orientation:
Minus strand

Genomic View for FBXO5 Gene

Genes around FBXO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO5 Gene

Proteins for FBXO5 Gene

  • Protein details for FBXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT4-FBX5_HUMAN
    Recommended name:
    F-box only protein 5
    Protein Accession:
    Q9UKT4
    Secondary Accessions:
    • B3KNX5
    • Q5TF47
    • Q8WV29
    • Q9UGC8

    Protein attributes for FBXO5 Gene

    Size:
    447 amino acids
    Molecular mass:
    50146 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with BTRC, FZR1/CDH1 and the N-terminal substrate-binding domain of CDC20. Also interacts with EVI5 which blocks its phosphorylation by PLK1 and prevents its subsequent binding to BTRC and degradation.

    Three dimensional structures from OCA and Proteopedia for FBXO5 Gene

    Alternative splice isoforms for FBXO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO5 Gene

Proteomics data for FBXO5 Gene at MOPED

Post-translational modifications for FBXO5 Gene

  • Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression.
  • Ubiquitinated by the by the SCF(BTRC) complex following phosphorylation by PLK1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FBXO5 Gene

Domains & Families for FBXO5 Gene

Gene Families for FBXO5 Gene

Protein Domains for FBXO5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKT4

UniProtKB/Swiss-Prot:

FBX5_HUMAN :
  • The C-terminal region is required for inhibition of APC activity.
  • Contains 1 IBR-type zinc finger.
Domain:
  • The C-terminal region is required for inhibition of APC activity.
  • Contains 1 F-box domain.
Similarity:
  • Contains 1 IBR-type zinc finger.
genes like me logo Genes that share domains with FBXO5: view

Function for FBXO5 Gene

Molecular function for FBXO5 Gene

UniProtKB/Swiss-Prot Function:
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
genes like me logo Genes that share phenotypes with FBXO5: view

Animal Models for FBXO5 Gene

MGI Knock Outs for FBXO5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO5 Gene

Localization for FBXO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO5 Gene COMPARTMENTS Subcellular localization image for FBXO5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11988738
GO:0005819 spindle IDA 15469984
genes like me logo Genes that share ontologies with FBXO5: view

Pathways & Interactions for FBXO5 Gene

genes like me logo Genes that share pathways with FBXO5: view

Pathways by source for FBXO5 Gene

SIGNOR curated interactions for FBXO5 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001556 oocyte maturation IEA --
GO:0007057 spindle assembly involved in female meiosis I IEA --
GO:0007088 regulation of mitotic nuclear division IBA --
genes like me logo Genes that share ontologies with FBXO5: view

Drugs & Compounds for FBXO5 Gene

No Compound Related Data Available

Transcripts for FBXO5 Gene

Unigene Clusters for FBXO5 Gene

F-box protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO5 Gene

No ASD Table

Relevant External Links for FBXO5 Gene

GeneLoc Exon Structure for
FBXO5
ECgene alternative splicing isoforms for
FBXO5

Expression for FBXO5 Gene

mRNA expression in normal human tissues for FBXO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO5 Gene



SOURCE GeneReport for Unigene cluster for FBXO5 Gene Hs.520506

genes like me logo Genes that share expression patterns with FBXO5: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXO5 Gene

Orthologs for FBXO5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO5 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FBXO5 35
  • 86.67 (n)
  • 81.35 (a)
FBXO5 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo5 35
  • 75.69 (n)
  • 67.22 (a)
Fbxo5 16
Fbxo5 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO5 35
  • 99.78 (n)
  • 99.33 (a)
FBXO5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo5 35
  • 73.78 (n)
  • 65.47 (a)
cow
(Bos Taurus)
Mammalia FBXO5 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO5 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves FBXO5 35
  • 62.17 (n)
  • 50.38 (a)
FBXO5 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO5 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo5 35
  • 56.31 (n)
  • 45.03 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo5 35
  • 46.37 (n)
  • 34.71 (a)
fbxo5 36
  • 30 (a)
OneToOne
Species with no ortholog for FBXO5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO5 Gene

ENSEMBL:
Gene Tree for FBXO5 (if available)
TreeFam:
Gene Tree for FBXO5 (if available)

Paralogs for FBXO5 Gene

Paralogs for FBXO5 Gene

genes like me logo Genes that share paralogs with FBXO5: view

Variants for FBXO5 Gene

Sequence variations from dbSNP and Humsavar for FBXO5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2073260 - 152,975,406(+) AAGTT(C/G)TACAA reference, missense
rs7763565 - 152,975,235(+) CAGGA(A/G)GCTAC reference, missense
rs1712 -- 152,970,730(+) GACAA(C/T)ACATT utr-variant-3-prime
rs1713 -- 152,970,788(+) AGGAA(C/T)ATAAA utr-variant-3-prime
rs1009899 -- 152,977,310(+) GTATA(C/T)AGCAT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXO5 Gene

Variant ID Type Subtype PubMed ID
esv24301 CNV Gain 19812545

Variation tolerance for FBXO5 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO5 Gene

HapMap Linkage Disequilibrium report
FBXO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO5 Gene

Disorders for FBXO5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
tetraploidy
  • tetraploidy syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FBXO5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FBXO5

Genetic Association Database (GAD)
FBXO5
Human Genome Epidemiology (HuGE) Navigator
FBXO5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO5
genes like me logo Genes that share disorders with FBXO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO5 Gene

Publications for FBXO5 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 67
  2. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (PMID: 15148369) Moshe Y. … Hershko A. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  3. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). (PMID: 11988738) Hsu J.Y. … Jackson P.K. (Nat. Cell Biol. 2002) 3 23
  4. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 3 23
  5. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3

Products for FBXO5 Gene

Sources for FBXO5 Gene

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