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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FBXO5 Gene

protein-coding GIFtS: 55
GCID: GC06M153291

F-box protein 5

(Previous name: F-box only protein 5 )

Explore 3 diseases affiliated with
FBXO5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
F-Box Protein 5¹ ²		F-Box Only Protein 5¹ ²
EMI1¹ ² ³ ⁵		Early Mitotic Inhibitor 1² ³
FBX5¹ ² ³ ⁵		F-Box Protein Fbx5²
Fbxo31¹ ²

External Ids:	HGNC: 13584¹	Entrez Gene: 26271²	Ensembl: ENSG00000112029⁷	OMIM: 606013⁵	UniProtKB: Q9UKT4³

Export aliases for FBXO5 gene to outside databases

Previous GC identifers: GC06M152852 GC06M153186 GC06M153322 GC06M153383 GC06M153333 GC06M150854

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO5:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,

the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs

(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3

classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different

protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs

class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that

interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding

different isoforms have been identified. (provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: FBX5_HUMAN, Q9UKT4

Function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC).

Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to

inhibit substrate-binding

Gene Wiki entry for FBXO5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FBXO5 gene promoter:
Tal-1 p53 COUP HNF-3beta HNF-4alpha1 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBXO5 promoter sequence

Search SABiosciences Chromatin IP Primers for FBXO5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q25-q26

FBXO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO5 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M153291: view genomic region (about GC identifiers)

Start:	153,291,658 bp from pter	End:	153,304,740 bp from pter
Size:	13,083 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBX5_HUMAN, Q9UKT4 (See protein sequence)

Recommended Name: F-box only protein 5

Size: 447 amino acids; 50146 Da

Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with BTRC, FZR1/CDH1 and

the N-terminal substrate-binding domain of CDC20. Also interacts with EVI5 which blocks its phosphorylation by PLK1

and prevents its subsequent binding to BTRC and degradation

Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate

manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the

cell, particularly at the spindle

Developmental stage: Accumulates in late G1 phase, levels rise during S phase and drop in early mitosis

Secondary accessions: B3KNX5 Q5TF47 Q8WV29 Q9UGC8

Alternative splicing: 2 isoforms: Q9UKT4-1 Q9UKT4-2

Explore the universe of human proteins at neXtProt for FBXO5: NX_Q9UKT4

Post-translational modifications:

Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated

proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for

the activation of APC in late mitosis and subsequent mitotic progression¹

Ubiquitinated by the by the SCF(BTRC) complex following phosphorylation by PLK1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UKT4

FBXO5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001135994.1 NP_036309.1

ENSEMBL proteins:

ENSP00000229758 ENSP00000356210

Reactome Protein details: Q9UKT4
Human Recombinant Protein Products:

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	Uscn Proteins for FBXO5

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	11988738
GO:0005819	spindle	IDA	15469984

FBXO5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FBXO5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FBXO5 for domains About GeneDecksing

1 InterPro domain/family:

IPR001810 F-box_dom_cyclin-like

Graphical View of Domain Structure for InterPro Entry Q9UKT4

ProtoNet protein and cluster: Q9UKT4

UniProtKB/Swiss-Prot: FBX5_HUMAN, Q9UKT4

Domain: The C-terminal region is required for inhibition of APC activity

Similarity: Contains 1 F-box domain

Similarity: Contains 1 IBR-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FBX5_HUMAN, Q9UKT4

Function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC).

Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to

inhibit substrate-binding

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FBXO5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO5
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO5:
		hsa-miR-433 hsa-miR-590-3p
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO5

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18662541
GO:0019901	protein kinase binding	IPI	15148369
GO:0046872	metal ion binding	IEA	--

FBXO5 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for FBXO5:

Cell cycle / mitosis defect	Cell division defect	Decreased viability of wild-ty	Increased 8N DNA content
Increased cell death in HCC-19	Increased cell number in G2M,

Animal Models:
Mouse knock-out Fbxo5^tm1Dlim for FBXO5
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fbxo5):

cellular

embryogenesis

mortality/aging

FBXO5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

SCF-mediated degradation of Emi1	0.87	Regulation of mitotic cell cycle	0.58
SCF-beta-TrCP mediated degradation of Emi1	0.87	APC/C-mediated degradation of cell cycle proteins	0.58
Regulation of APC/C activators between G1/S and early anaphase	0.62

M Phase

	M Phase	1.00			Mitotic Metaphase and Anaphase	0.85
	Mitotic M-M/G1 phases	0.88

G1/S-Specific Transcription

	G1/S-Specific Transcription	1.00			E2F mediated regulation of DNA replication	0.45
	Activation of E2F target genes at G1/S	1.00

Cell cycle_Role of SCF complex in cell cycle regulation

Cell cycle_Role of SCF complex in cell cycle regulation

1.00

Cell cycle Role of SCF complex in cell cycle regulation

0.98

G1/S Transition

G1/S Transition

1.00

Mitotic G1-G1/S phases

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FBXO5

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Role of SCF complex in cell cycle regulation

2 GeneGo (Thomson Reuters) Pathways for FBXO5

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Role of SCF complex in cell cycle regulation

1 BioSystems Pathway for FBXO5

PLK1 signaling events

5/17 Reactome Pathways for FBXO5 (see all 17)

	SCF-beta-TrCP mediated degradation of Emi1
	SCF-mediated degradation of Emi1
	Mitotic G1-G1/S phases
	Cell Cycle
	M Phase

1 Kegg Pathway (Kegg details for FBXO5):

Oocyte meiosis

FBXO5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FBXO5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for FBXO5 (Q9UKT4^{1, 2, 3} ENSP00000229758⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKP1	P63208²^,³, ENSP00000231487⁴	MINT-4789761 I2D: score=4 STRING: ENSP00000231487
EVI5	O60447¹^,³, ENSP00000359356⁴	EBI-852298,EBI-852291 I2D: score=3 STRING: ENSP00000359356
CDC27	P30260¹^,³	EBI-852298,EBI-994813 I2D: score=1
BTRC	Q9Y297³, ENSP00000359206⁴	I2D: score=2 STRING: ENSP00000359206
FZR1	Q9UM11³, ENSP00000378529⁴	I2D: score=2 STRING: ENSP00000378529

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	TAS	--
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000089	mitotic metaphase	IEA	--
GO:0000278	mitotic cell cycle	TAS	--

FBXO5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FBXO5
Search CenterWatch for drugs/clinical trials and news about FBXO5 / FBX5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FBXO5 gene (2 alternative transcripts):

NM_001142522.1 NM_012177.3

Unigene Cluster for FBXO5:

F-box protein 5

Hs.520506 [show with all ESTs]

Unigene Representative Sequence: NM_001142522

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000477822 ENST00000229758(uc003qpg.3) ENST00000367241(uc003qph.3)

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		hsa-miR-433 hsa-miR-590-3p
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Additional cDNA sequence:

AF129535.1 AJ420499.1 AK026197.1 AK055221.1 AK314456.1 AY079515.1 BC018905.1

6 DOTS entries:

DT.95268454 DT.40251444 DT.92424884 DT.95268452 DT.100692634 DT.92424883

24/102 AceView cDNA sequences (see all 102):

CN482454 AL711051 AA954828 AA287101 BQ230276 BC018905 AI810690 AA737163

BM675277 AJ420499 NM_012177 AA721465 BQ934154 AI354876 CB990565 AA283166

AA262860 BE349323 BM970324 AA283003 AA772464 AA806014 BX446009 AA811976

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FBXO5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATATTTC

About this image

FBXO5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FBXO5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO5

SOURCE GeneReport for Unigene cluster: Hs.520506

SABiosciences Expression via Pathway-Focused PCR Array including FBXO5:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FBXO5 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FBXO5¹	F-box protein 5	62.09(n) 50.38(a)		421642 XM_419681.3 XP_419681.3
lizard (Anolis carolinensis)	Reptilia	FBXO5⁶	--	47(a)	1 ↔ 1	1(215824475-215827958)
zebrafish (Danio rerio)	Actinopterygii	fbxo5¹	F-box protein 5	46.37(n) 34.71(a)		445392 NM_001003869.1 NP_001003869.1

ENSEMBL Gene Tree for FBXO5 (if available)
TreeFam Gene Tree for FBXO5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FBXO5 gene

FBXO43²

FBXO5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9397573^1,2	C,F,A,H,	--	153291277(+)	`GCACAA/CATGTT`	2	--	ds500¹		8		NS EA NA	664
rs9397574^1,2	C,F,A,H,	--	153291356(+)	`GTGCTA/TTTTAA`	2	--	ds500¹		7		NS EA NA	650
rs9371273^1,2	C,F,A,H,	--	153291428(+)	`TATGGT/CCTTCC`	2	--	ds500¹		16		NS EA NA WA CSA	795
rs151296702^1,2		--	153291578(+)	`ATTCAA/GTGCCT`	2	--	ds500¹		0	--	--	--	--
rs9371656^1,2	C,F,H,	--	153291593(+)	`ACAAAT/CGCAGT`	2	--	ds500¹		18		NS EA WA NA CSA	1989
rs71556270^1,2	C,F,	--	153291593(+)	`CAAACAAAT/- GCAGT`	2	--	ds500¹		2		NA CSA	4
rs1712^1,2	C,F,A,H,	--	153291865(+)	`GACAAC/TACATT`	2	--	ut3¹		34		NS NA EA CSA WA	3031
rs76686834^1,2	C,F,	--	153291883(+)	`CTCCAG/AAAGTT`	2	--	ut3¹		1		NA	120
rs1713^1,2	C,F,O,A,H,	--	153291923(+)	`AGGAAC/TATAAA`	2	--	ut3¹		22		NS MN NA EA CSA WA	1227
rs79257289^1,2	C,	--	153291986(+)	`TAAAAT/CTGCAT`	2	--	ut3¹		2		WA	120

HapMap Linkage Disequilibrium report for FBXO5 (153291658 - 153304740 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FBXO5
3 CNVs: 94116 81659 94117
1 Indel: 69624

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO5

DNA2.0 Custom Variant and Variant Library Synthesis for FBXO5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FBXO5 for disorders           About GeneDecksing

OMIM gene information: 606013    OMIM disorders: --

3 diseases for FBXO5:    About MalaCards

tetraploidy breast cancer carcinoma

Human Genome Epidemiology (HuGE) Navigator: FBXO5 (2 documents)

Export disorders for FBXO5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FBXO5 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with FBXO5)

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Identification of a family of human F-box proteins. (PubMed id 10531035)^{1, 2, 3} Cenciarelli C....Pagano M. (1999)
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (PubMed id 15148369)^{1, 2, 9} Moshe Y.... Hershko A. (2004)
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). (PubMed id 11988738)^{1, 2, 9} Hsu J.Y.... Jackson P.K. (2002)
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. (PubMed id 16439210)^{1, 2} Eldridge A.G.... Jackson P.K. (2006)
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. (PubMed id 16921029)^{1, 2} Miller J.J.... Jackson P.K. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1. (PubMed id 15469984)^{1, 2} Hansen D.V.... Jackson P.K. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. (PubMed id 12791267)^{1, 2} Margottin-Goguet F....Jackson P.K. (2003)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26271	HGNC: 13584	AceView: FBXO5	Ensembl:ENSG00000112029	euGenes: HUgn26271
ECgene: FBXO5	Kegg: 26271	H-InvDB: FBXO5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FBXO5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FBXO5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FBXO5 gene:
Search GeneIP for patents involving FBXO5

GeneCards and IP:
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