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FBXO5 Gene(Protein Coding)

F-Box Protein 5

GCID:
GC06M152970
GIFtS:
51
Genes Participants
UDN Logo

Aliases for FBXO5 Gene

Aliases for FBXO5 Gene

  • F-Box Protein 5 2 3 5
  • Early Mitotic Inhibitor 1 3 4
  • F-Box Only Protein 5 2 3
  • EMI1 3 4
  • FBX5 3 4
  • F-Box Protein Fbx5 3
  • Fbxo31 3

External Ids for FBXO5 Gene

Previous GeneCards Identifiers for FBXO5 Gene

  • GC06M152852
  • GC06M153186
  • GC06M153322
  • GC06M153383
  • GC06M153333
  • GC06M153291
  • GC06M150854

Summaries for FBXO5 Gene

Entrez Gene Summary for FBXO5 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

GeneCards Summary for FBXO5 Gene

FBXO5 (F-Box Protein 5) is a Protein Coding gene. Among its related pathways are PLK1 signaling events and Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is FBXO43.

UniProtKB/Swiss-Prot for FBXO5 Gene

  • Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

Gene Wiki entry for FBXO5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO5 Gene

Genomics for FBXO5 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBXO5 Gene

Enhancers for FBXO5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G152980 1.1 ENCODE 21.8 +0.5 514 5.7 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 MTRF1L FBXO5 RPL27AP6 ENSG00000227627 ENSG00000220745
GH06G152099 1.1 Ensembl ENCODE 13.2 +883.3 883324 1.4 ZFP64 KLF17 GATA2 EGR1 FOS EGR2 ZNF202 ZNF680 ZNF654 ZBTB11 HSPA8P15 FBXO5 PIR34901 GC06P152365
GH06G152093 1.3 Ensembl ENCODE 10.9 +887.5 887530 4.5 PKNOX1 ARNT FEZF1 GATA2 ZNF143 FOS SP3 TSHZ1 ZNF662 ZNF610 FBXO5 ZBTB2 PIR34901 GC06P152365
GH06G152458 0.9 ENCODE 10.9 +524.6 524630 1.4 MLX INSM2 FEZF1 ZNF366 ZSCAN5C SCRT2 ZNF350 EGR2 SP3 CEBPB FBXO5 RNA5SP223 ENSG00000226193 SYNE1 GC06P152451 NANOGP11
GH06G152049 0.6 ENCODE 12.2 +933.1 933055 1.3 NFIC NFIB ZNF530 PCBP1 ZNF300 ZNF843 PRDM1 FBXO5 ENSG00000233823 HSPA8P15 PIR34901 GC06P152365
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO5 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000205457 705 3801 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1

Transcription factor binding sites by QIAGEN in the FBXO5 gene promoter:

Genomic Location for FBXO5 Gene

Chromosome:
6
Start:
152,970,519 bp from pter
End:
152,983,605 bp from pter
Size:
13,087 bases
Orientation:
Minus strand

Genomic View for FBXO5 Gene

Genes around FBXO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO5 Gene

Proteins for FBXO5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FBXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT4-FBX5_HUMAN
    Recommended name:
    F-box only protein 5
    Protein Accession:
    Q9UKT4
    Secondary Accessions:
    • B3KNX5
    • Q5TF47
    • Q8WV29
    • Q9UGC8

    Protein attributes for FBXO5 Gene

    Size:
    447 amino acids
    Molecular mass:
    50146 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with BTRC, FZR1/CDH1 and the N-terminal substrate-binding domain of CDC20. Also interacts with EVI5 which blocks its phosphorylation by PLK1 and prevents its subsequent binding to BTRC and degradation.

    Three dimensional structures from OCA and Proteopedia for FBXO5 Gene

    Alternative splice isoforms for FBXO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO5 Gene

Protein Expression for FBXO5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO5 Gene

  • Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression.
  • Ubiquitinated by the by the SCF(BTRC) complex following phosphorylation by PLK1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO5 Gene

Domains & Families for FBXO5 Gene

Gene Families for FBXO5 Gene

HGNC:

Protein Domains for FBXO5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKT4

UniProtKB/Swiss-Prot:

FBX5_HUMAN :
  • The C-terminal region is required for inhibition of APC activity.
Domain:
  • The C-terminal region is required for inhibition of APC activity.
genes like me logo Genes that share domains with FBXO5: view

Function for FBXO5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBXO5 Gene

UniProtKB/Swiss-Prot Function:
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

Gene Ontology (GO) - Molecular Function for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11988738
GO:0019901 protein kinase binding IPI 15148369
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FBXO5: view
genes like me logo Genes that share phenotypes with FBXO5: view

Animal Models for FBXO5 Gene

MGI Knock Outs for FBXO5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO5 Gene

Localization for FBXO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11988738
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 11988738
GO:0005819 spindle IDA,IEA 15469984
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO5: view

Pathways & Interactions for FBXO5 Gene

genes like me logo Genes that share pathways with FBXO5: view

Pathways by source for FBXO5 Gene

1 BioSystems pathway for FBXO5 Gene
1 KEGG pathway for FBXO5 Gene

SIGNOR curated interactions for FBXO5 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0001556 oocyte maturation IEA --
GO:0007049 cell cycle IEA --
GO:0007057 spindle assembly involved in female meiosis I IEA --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with FBXO5: view

Drugs & Compounds for FBXO5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FBXO5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBXO5 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(102) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO5 Gene

F-box protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO5 Gene

No ASD Table

Relevant External Links for FBXO5 Gene

GeneLoc Exon Structure for
FBXO5
ECgene alternative splicing isoforms for
FBXO5

Expression for FBXO5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO5 Gene

mRNA expression in normal human tissues for FBXO5 Gene
mRNA expression by BioGPS for FBXO5 GenemRNA expression by GTEx for FBXO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO5 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXO5 Gene:

FBXO5

SOURCE GeneReport for Unigene cluster for FBXO5 Gene:

Hs.520506
genes like me logo Genes that share expression patterns with FBXO5: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO5 Gene

Orthologs for FBXO5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBXO5 34 35
  • 99.78 (n)
dog
(Canis familiaris)
 Mammalia FBXO5 34 35
  • 86.67 (n)
cow
(Bos Taurus)
 Mammalia FBXO5 35
  • 81 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fbxo5 34 16 35
  • 75.69 (n)
rat
(Rattus norvegicus)
 Mammalia Fbxo5 34
  • 73.78 (n)
oppossum
(Monodelphis domestica)
 Mammalia FBXO5 35
  • 64 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 55 (a)
 OneToMany
-- 35
  • 50 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves FBXO5 34 35
  • 62.17 (n)
lizard
(Anolis carolinensis)
 Reptilia FBXO5 35
  • 46 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo5 34
  • 56.31 (n)
zebrafish
(Danio rerio)
 Actinopterygii fbxo5 34 35
  • 46.37 (n)
Species where no ortholog for FBXO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO5 Gene

ENSEMBL:
Gene Tree for FBXO5 (if available)
TreeFam:
Gene Tree for FBXO5 (if available)

Paralogs for FBXO5 Gene

Paralogs for FBXO5 Gene

genes like me logo Genes that share paralogs with FBXO5: view

Variants for FBXO5 Gene

Sequence variations from dbSNP and Humsavar for FBXO5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000530212 -- 152,985,100(+) CAATA(C/G)GTTAG upstream-variant-2KB
rs1000583458 -- 152,979,244(+) TCCAG(A/G)ATACA intron-variant
rs1000770116 -- 152,972,556(+) GATTA(G/T)GTAAG intron-variant
rs1000859209 -- 152,984,815(+) GGCAA(G/T)GCAGG upstream-variant-2KB
rs1000936503 -- 152,971,707(+) AAAAT(A/T)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO5 Gene

Variant ID Type Subtype PubMed ID
esv24301 CNV gain 19812545
nsv1150330 CNV insertion 26484159

Variation tolerance for FBXO5 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO5 Gene

Disorders for FBXO5 Gene

Relevant External Links for FBXO5

Genetic Association Database (GAD)
FBXO5
Human Genome Epidemiology (HuGE) Navigator
FBXO5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO5

No disorders were found for FBXO5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO5 Gene

Publications for FBXO5 Gene

  1. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (PMID: 15148369) Moshe Y. … Hershko A. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64
  2. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). (PMID: 11988738) Hsu J.Y. … Jackson P.K. (Nat. Cell Biol. 2002) 3 4 22 64
  3. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  4. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei S.F. … Deng H.W. (J. Bone Miner. Res. 2011) 3 46 64
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64

Products for FBXO5 Gene

  • Addgene plasmids for FBXO5

Sources for FBXO5 Gene

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