Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXO5 Gene

protein-coding   GIFtS: 60
GCID: GC06M153291

F-Box Protein 5

(Previous name: F-box only protein 5)
  See FBXO5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box Protein 51 2     Early Mitotic Inhibitor 12 3
EMI12 3 5     Fbxo312
FBX52 3 5     F-Box Protein Fbx52
F-Box Only Protein 51 2     

External Ids:    HGNC: 135841   Entrez Gene: 262712   Ensembl: ENSG000001120297   OMIM: 6060135   UniProtKB: Q9UKT43   

Export aliases for FBXO5 gene to outside databases

Previous GC identifers: GC06M152852 GC06M153186 GC06M153322 GC06M153383 GC06M153333 GC06M150854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXO5 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which
is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively
spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Dec 2008)

GeneCards Summary for FBXO5 Gene:
FBXO5 (F-box protein 5) is a protein-coding gene. Diseases associated with FBXO5 include tetraploidy. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is FBXO43.

UniProtKB/Swiss-Prot: FBX5_HUMAN, Q9UKT4
Function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome
(APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the
APC to inhibit substrate-binding

Gene Wiki entry for FBXO5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO5 gene promoter:
         Tal-1   p53   COUP   HNF-3beta   HNF-4alpha1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO5 promoter sequence
   Search Chromatin IP Primers for FBXO5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25-q26

FBXO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M153291:  view genomic region     (about GC identifiers)

Start:
153,291,658 bp from pter      End:
153,304,740 bp from pter
Size:
13,083 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBX5_HUMAN, Q9UKT4 (See protein sequence)
Recommended Name: F-box only protein 5  
Size: 447 amino acids; 50146 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with BTRC, FZR1/CDH1
and the N-terminal substrate-binding domain of CDC20. Also interacts with EVI5 which blocks its phosphorylation
by PLK1 and prevents its subsequent binding to BTRC and degradation
Developmental stage: Accumulates in late G1 phase, levels rise during S phase and drop in early mitosis
1 PDB 3D structure from and Proteopedia for FBXO5:
2M6N (3D)    
Secondary accessions: B3KNX5 Q5TF47 Q8WV29 Q9UGC8
Alternative splicing: 2 isoforms:  Q9UKT4-1   Q9UKT4-2   

Explore the universe of human proteins at neXtProt for FBXO5: NX_Q9UKT4

Explore proteomics data for FBXO5 at MOPED

Post-translational modifications: 

  • Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through
    ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This
    degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression1
  • Ubiquitinated by the by the SCF(BTRC) complex following phosphorylation by PLK11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135994.1  NP_036309.1  

    ENSEMBL proteins: 
     ENSP00000229758   ENSP00000356210  
    Reactome Protein details: Q9UKT4

    FBXO5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FBXO5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FBXO5
    GenScript Custom Purified and Recombinant Proteins Services for FBXO5
    Novus Biologicals FBXO5 Proteins
    Novus Biologicals FBXO5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO5

     
    Search eBioscience for Proteins for FBXO5 

     
    antibodies-online proteins for FBXO5 (4 products) 

     
    antibodies-online peptides for FBXO5

    FBXO5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FBXO5
    OriGene Custom Antibody Services for FBXO5
    Novus Biologicals FBXO5 Antibodies
    Abcam antibodies for FBXO5
    Cloud-Clone Corp. Antibodies for FBXO5
    ThermoFisher Antibodies for FBXO5
    antibodies-online antibodies for FBXO5 (17 products) 

    FBXO5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXO5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXO5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXO5
    Cloud-Clone Corp. CLIAs for FBXO5
    Search eBioscience for ELISAs for FBXO5 
    antibodies-online kits for FBXO5 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKT4

    ProtoNet protein and cluster: Q9UKT4

    UniProtKB/Swiss-Prot: FBX5_HUMAN, Q9UKT4
    Domain: The C-terminal region is required for inhibition of APC activity
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 IBR-type zinc finger


    Find genes that share domains with FBXO5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX5_HUMAN, Q9UKT4
    Function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome
    (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the
    APC to inhibit substrate-binding

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11988738
    GO:0019901protein kinase binding IPI15148369
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with FBXO5           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for FBXO5:
     Cell cycle / mitosis defect  Cell division defect  Decreased viability of wild-ty  Increased 8N DNA content 
     Increased cell death in HCC-19  Increased cell number in G2M,  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fbxo5):
     cellular  embryogenesis  mortality/aging 

    Find genes that share phenotypes with FBXO5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fbxo5tm1Dlim for FBXO5

       genOway: Develop your customized and physiologically relevant rodent model for FBXO5

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXO5:
    hsa-mir-26b-5p (MIRT030275), hsa-mir-192-5p (MIRT026894), hsa-mir-215-5p (MIRT024627), hsa-mir-193b-3p (MIRT016524), hsa-mir-151a-3p (MIRT019510)

    Block miRNA regulation of human, mouse, rat FBXO5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FBXO5:
    hsa-miR-433 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO5
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXO5

    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO5 (see all 12)
    OriGene ORF clones in mouse, rat for FBXO5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO5 (NM_012177)
    Sino Biological Human cDNA Clone for FBXO5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO5
    Addgene plasmids for FBXO5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXO5
    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO5

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14029) for FBXO5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FBX5_HUMAN, Q9UKT4: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a
    punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes
    throughout the cell, particularly at the spindle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    mitochondrion3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA11988738
    GO:0005819spindle IDA15469984

    Find genes that share ontologies with FBXO5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FBXO5 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1PLK1 signaling events
    Mitotic Metaphase/Anaphase Transition0.00
    PLK1 signaling events
    Phosphorylation of Emi10.00
    2CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Regulation of mitotic cell cycle0.94
    Regulation of APC/C activators between G1/S and early anaphase0.94
    SCF-beta-TrCP mediated degradation of Emi10.91
    3E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    G1/S-Specific Transcription0.00
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Mitotic Metaphase and Anaphase
    Mitotic Metaphase and Anaphase0.93


    Find genes that share SuperPaths with FBXO5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for FBXO5
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of SCF complex in cell cycle regulation

    1 BioSystems Pathway for FBXO5
        PLK1 signaling events


    Selected Reactome Pathways for FBXO5 (see all 6)
        SCF-beta-TrCP mediated degradation of Emi1
    Regulation of APC/C activators between G1/S and early anaphase
    Phosphorylation of Emi1
    Mitotic Metaphase/Anaphase Transition
    E2F mediated regulation of DNA replication


    1 Kegg Pathway  (Kegg details for FBXO5):
        Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO5: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FBXO5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXO5 (Q9UKT41, 2, 3 ENSP000002297584) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632082, 3, ENSP000002314874MINT-4789761 I2D: score=4 STRING: ENSP00000231487
    EVI5O604471, 3, ENSP000003593564EBI-852298,EBI-852291 I2D: score=3 STRING: ENSP00000359356
    CDC27P302601, 3EBI-852298,EBI-994813 I2D: score=1 
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    FZR1Q9UM113, ENSP000003785294I2D: score=2 STRING: ENSP00000378529
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001556oocyte maturation IEA--
    GO:0007057spindle assembly involved in female meiosis I IEA--

    Find genes that share ontologies with FBXO5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO5 (FBX5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FBXO5 gene (2 alternative transcripts): 
    NM_001142522.1  NM_012177.3  

    Unigene Cluster for FBXO5:

    F-box protein 5
    Hs.520506  [show with all ESTs]
    Unigene Representative Sequence: NM_001142522
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477822 ENST00000229758(uc003qpg.3) ENST00000367241(uc003qph.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXO5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FBXO5:
    hsa-miR-433 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXO5
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO5
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO5 (see all 12)
    OriGene ORF clones in mouse, rat for FBXO5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO5 (NM_012177)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO5
    Addgene plasmids for FBXO5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXO5
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO5
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO5
      QuantiFast Probe-based Assays in human, mouse, rat FBXO5
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14029) for FBXO5 

    Additional mRNA sequence: 

    AF129535.1 AJ420499.1 AK026197.1 AK055221.1 AK314456.1 AY079515.1 BC018905.1 

    6 DOTS entries:

    DT.95268454  DT.40251444  DT.92424884  DT.95268452  DT.100692634  DT.92424883 

    Selected AceView cDNA sequences (see all 102):

    BE349323 AA737163 BQ934154 BC018905 AJ420499 BM675277 AA811976 AA721465 
    AA283003 AA262860 BX446009 BM970324 AI354876 AA954828 CN482454 AA287101 
    AA283166 AL711051 BQ230276 CB990565 AA806014 NM_012177 AY079515 AI810690 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FBXO5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATATTTC
    FBXO5 Expression
    About this image


    FBXO5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    FBXO5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520506
        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO5: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXO5
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO5
    QuantiTect SYBR Green Assays in human, mouse, rat FBXO5
    QuantiFast Probe-based Assays in human, mouse, rat FBXO5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo51 , 5 F-box protein 51, 5 75.69(n)1
    67.22(a)1
      10 (1.91 cM)5
    671411  NM_025995.21  NP_080271.21 
     57991605 
    chicken
    (Gallus gallus)
    Aves FBXO51 F-box protein 5 62.17(n)
    50.38(a)
      421642  XM_419681.4  XP_419681.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO56
    F-box protein 5
    46(a)
    1 ↔ 1
    1(215824440-215828694)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo51 F-box protein 5 56.31(n)
    45.03(a)
      733555  NM_001044469.1  NP_001037934.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo51 F-box protein 5 46.37(n)
    34.71(a)
      445392  NM_001003869.1  NP_001003869.1 


    ENSEMBL Gene Tree for FBXO5 (if available)
    TreeFam Gene Tree for FBXO5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FBXO5 gene
    FBXO432  

    Find genes that share paralogs with FBXO5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FBXO5 (see all 293)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs93975731,2
    C,F,A,H--153291277(+) GCACAA/CATGTT 2 -- ds50018Minor allele frequency- C:0.14NS EA NA 664
    rs93975741,2
    C,F,A,H--153291356(+) GTGCTA/TTTTAA 2 -- ds50017Minor allele frequency- T:0.13NS EA NA 650
    rs93712731,2
    C,F,A,H--153291428(+) TATGGT/CCTTCC 2 -- ds500116Minor allele frequency- C:0.25NS EA NA WA CSA 795
    rs1512967021,2
    C--153291578(+) ATTCAA/GTGCCT 2 -- ds50010--------
    rs1401438161,2
    C--153291587(+) TTCAC-/AAA   
      A
    /ACAA
    ACAAA
    2 -- ds50010--------
    rs93716561,2
    C,F,H--153291593(+) ACAAAT/CGCAGT 2 -- ds500118Minor allele frequency- C:0.45NS EA WA NA CSA 1989
    rs715562701,2
    C,F--153291593(+) CAAACAAAT/-  
            
    GCAGT
    2 -- ds50012Minor allele frequency- -:0.50NA CSA 4
    rs666103031,2
    C--153291594(+) AAACG-/AAAT  
            
    CAGTC
    2 -- ds50010--------
    rs17121,2
    C,F,A,H--153291865(+) GACAAC/TACATT 2 -- ut3134Minor allele frequency- T:0.22NS NA EA CSA WA 3031
    rs766868341,2
    C,F--153291883(+) CTCCAG/AAAGTT 2 -- ut311Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for FBXO5 (153291658 - 153304740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FBXO5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24301CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO5
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606013    OMIM disorders: --

    1 disease for FBXO5:    
    About MalaCards
    tetraploidy


    Find genes that share disorders with FBXO5           About GenesLikeMe

    Genetic Association Database (GAD): FBXO5
    Human Genome Epidemiology (HuGE) Navigator: FBXO5 (2 documents)

    Export disorders for FBXO5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FBXO5 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with FBXO5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (PubMed id 15148369)1, 2, 9 Moshe Y.... Hershko A. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). (PubMed id 11988738)1, 2, 9 Hsu J.Y.... Jackson P.K. (Nat. Cell Biol. 2002)
    4. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PubMed id 20641033)1, 4 Lei S.F....Deng H.W. (J. Bone Miner. Res. 2011)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. (PubMed id 16439210)1, 2 Eldridge A.G.... Jackson P.K. (Cell 2006)
    7. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. (PubMed id 16921029)1, 2 Miller J.J.... Jackson P.K. (Genes Dev. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1. (PubMed id 15469984)1, 2 Hansen D.V.... Jackson P.K. (Mol. Biol. Cell 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26271 HGNC: 13584 AceView: FBXO5 Ensembl:ENSG00000112029 euGenes: HUgn26271
    ECgene: FBXO5 Kegg: 26271 H-InvDB: FBXO5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FBXO5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FBXO5 gene:
    Search GeneIP for patents involving FBXO5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FBXO5   OriGene RNAi products in human, mouse, rat for FBXO5  
     OriGene qPCR primer pairs and template standards for FBXO5   OriGene Protein Over-expression Lysate for FBXO5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXO5  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXO5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXO5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXO5   OriGene Custom Protein Services for FBXO5  

     
     
     Block miRNA regulation of human, mouse, rat FBXO5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXO5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO5 Predesigned siRNA for gene silencing in human, mouse, rat FBXO5
     QuantiFast Probe-based Assays in human, mouse, rat FBXO5 QuantiTect SYBR Green Assays in human, mouse, rat FBXO5
     PCR Arrays including human, mouse, rat FBXO5 Search Chromatin IP Primers for FBXO5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO5  GeneGlobe Interaction Network for FBXO5
     Regulatory tfbs in FBXO5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FBXO5 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO5
     GenScript Custom Assay Services for FBXO5 GenScript Custom overexpressing Cell Line Services for FBXO5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FBXO5 (FBX5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FBXO5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FBXO5 antibodies
     FBXO5 proteins
     FBXO5 lysates
     Antibodies for FBXO5
     See all of Abcam's Antibodies, Kits and Proteins for FBXO5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FBXO5
     Antibodies for FBXO5
     ELISAs for FBXO5
     CLIAs for FBXO5



     Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO5
     SwitchGear 3'UTR luciferase reporter plasmids for FBXO5
     SwitchGear Promoter luciferase reporter plasmids for FBXO5
     ThermoFisher Antibodies for FBXO5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO5
     Browse compounds at ApexBio
     Addgene plasmids for FBXO5
      Search eBioscience for proteins for FBXO5
      Search eBioscience for elisas for FBXO5
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FBXO5
     antibodies-online antibodies for FBXO5 (17 products)
     antibodies-online kits for FBXO5 (16 products)
     antibodies-online peptides for FBXO5
     antibodies-online proteins for FBXO5 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXO5 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4