Aliases for FBXO47 Gene
External Ids for FBXO47 Gene
- HGNC: 31969
- Entrez Gene: 494188
- Ensembl: ENSG00000204952
- OMIM: 609498
- UniProtKB: Q5MNV8
Previous GeneCards Identifiers for FBXO47 Gene
- GC17U900551
- GC17M034346
- GC17M037092
- GC17M032887
Summaries for FBXO47 Gene
GeneCards Summary for FBXO47 Gene
FBXO47 (F-Box Protein 47) is a Protein Coding gene. Diseases associated with FBXO47 include Renal Cell Carcinoma, Papillary.
UniProtKB/Swiss-Prot for FBXO47 Gene
-
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO47 Gene
Genomics for FBXO47 Gene
Regulatory Elements for FBXO47 Gene
Enhancers for FBXO47 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO47 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FBXO47 Gene
- Chromosome:
- 17
- Start:
- 38,936,278 bp from pter
- End:
- 38,967,486 bp from pter
- Size:
- 31,209 bases
- Orientation:
- Minus strand
Genomic View for FBXO47 Gene
Genes around FBXO47 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12|17q12 by Entrez Gene
- 17q12 by HGNC
FBXO47 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO47 Gene
Proteins for FBXO47 Gene
-
Protein details for FBXO47 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5MNV8-FBX47_HUMAN
- Recommended name:
- F-box only protein 47
- Protein Accession:
- Q5MNV8
- B2RTZ4
Protein attributes for FBXO47 Gene
- Size:
- 452 amino acids
- Molecular mass:
- 51968 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Post-translational modifications for FBXO47 Gene
Other Protein References for FBXO47 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for FBXO47
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Protein Products
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- antibodies-online Proteins for FBXO47: See all 4
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- Search GeneTex for Proteins for FBXO47
-
Abcam proteins for FBXO47
Assay Products
- antibodies-online Kits for FBXO47: See all 15
No data available for DME Specific Peptides for FBXO47 Gene
Domains & Families for FBXO47 Gene
Gene Families for FBXO47 Gene
- HGNC:
Suggested Antigen Peptide Sequences for FBXO47 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO47 Gene
Function for FBXO47 Gene
Molecular function for FBXO47 Gene
- UniProtKB/Swiss-Prot Function:
- Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Phenotypes for FBXO47 Gene
- MGI mutant phenotypes for FBXO47:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXO47:
Animal Models for FBXO47 Gene
- MGI Knock Outs for FBXO47:
-
- Fbxo47 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO47 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for FBXO47
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO47
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miRNA for FBXO47 Gene
- miRTarBase miRNAs that target FBXO47
-
- hsa-mir-642a-5p (MIRT537402)
- hsa-mir-4420 (MIRT537403)
- hsa-mir-452-3p (MIRT537404)
- hsa-mir-181b-3p (MIRT537405)
- hsa-mir-181b-2-3p (MIRT537406)
- hsa-mir-1304-3p (MIRT537407)
- hsa-mir-2276-5p (MIRT537408)
- hsa-mir-6892-3p (MIRT537409)
- hsa-mir-2114-5p (MIRT537410)
- hsa-mir-4724-3p (MIRT537411)
- hsa-mir-1252-5p (MIRT537412)
- hsa-mir-654-3p (MIRT537413)
- hsa-mir-1277-5p (MIRT537414)
- hsa-mir-651-3p (MIRT537415)
- hsa-mir-186-5p (MIRT537416)
- hsa-mir-3133 (MIRT537417)
- hsa-mir-335-3p (MIRT613839)
- hsa-mir-1305 (MIRT613840)
- hsa-mir-874-3p (MIRT613841)
- hsa-mir-3157-3p (MIRT613842)
- hsa-mir-6886-3p (MIRT623947)
- hsa-mir-938 (MIRT623948)
- hsa-mir-6778-3p (MIRT631459)
- hsa-mir-1976 (MIRT631460)
- hsa-mir-3653-5p (MIRT631461)
- hsa-mir-150-5p (MIRT631462)
- hsa-mir-6747-3p (MIRT631463)
- hsa-mir-6727-3p (MIRT631464)
- hsa-mir-4722-3p (MIRT631465)
- hsa-mir-4661-5p (MIRT631466)
- hsa-mir-4279 (MIRT639302)
- hsa-mir-5571-5p (MIRT639303)
- hsa-mir-498 (MIRT668368)
- hsa-mir-23b-5p (MIRT668369)
- hsa-mir-23a-5p (MIRT668370)
- hsa-mir-6506-5p (MIRT668371)
- hsa-mir-619-5p (MIRT668372)
- hsa-mir-6742-3p (MIRT668373)
- hsa-mir-5089-5p (MIRT671584)
- hsa-mir-6504-3p (MIRT671585)
miRNA Products
- Search ViGene Biosciences for FBXO47
Inhibitory RNA Products
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-
Horizon Cell Lines for FBXO47
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO47 Gene
Localization for FBXO47 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO47 Gene
Transcripts for FBXO47 Gene
mRNA/cDNA for FBXO47 Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXO47 Gene
- F-box protein 47:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FBXO47
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO47
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miRNA Products
- Search ViGene Biosciences for FBXO47
Inhibitory RNA Products
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Expression for FBXO47 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
-
Gonad
- XX Germ Cells Ovigerous Cord
mRNA differential expression in normal tissues according to GTEx for FBXO47 Gene
This gene is overexpressed in Testis (x43.3).
NURSA nuclear receptor signaling pathways regulating expression of FBXO47 Gene:
FBXO47SOURCE GeneReport for Unigene cluster for FBXO47 Gene:
Hs.549536mRNA Expression by UniProt/SwissProt for FBXO47 Gene:
Q5MNV8-FBX47_HUMAN
Tissue specificity:
Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.
Primer Products
-
OriGene qPCR primer pairs for FBXO47
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO47 Gene
Orthologs for FBXO47 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO47 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXO47 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO47 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo47 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO47 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fbxo47 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO47 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO47 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FBXO47 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo47 34 |
|
- Species where no ortholog for FBXO47 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FBXO47 Gene
No data available for Paralogs for FBXO47 Gene
Variants for FBXO47 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000032577 | -- | 38,960,693(+) | GTGGC(A/G)TGACC | intron-variant | |
| rs1000058289 | -- | 38,941,660(+) | TATGT(A/G)TGTGT | intron-variant | |
| rs1000097458 | -- | 38,962,377(+) | TTGGG(A/C)GGCCA | intron-variant | |
| rs1000297715 | -- | 38,941,396(+) | AACTC(C/G)TGACC | intron-variant | |
| rs1000315983 | -- | 38,955,152(+) | GGAGG(C/T)CGAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1193917 | CNV | insertion | 17803354 |
| esv2669787 | CNV | deletion | 23128226 |
| esv3640533 | CNV | loss | 21293372 |
| nsv1071382 | CNV | deletion | 25765185 |
| nsv1146669 | OTHER | inversion | 26484159 |
Residual Variation Intolerance Score:
92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.04;
50.35% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO47 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO47
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO47 Gene
Disorders for FBXO47 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| renal cell carcinoma, papillary |
|
|
Search FBXO47 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FBXO47
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXO47
No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO47 Gene
Publications for FBXO47 Gene
- Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma. (PMID: 15723337) Simon-Kayser B. … Bezieau S. (Genes Chromosomes Cancer 2005) 2 3 4 64
- Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
Products for FBXO47 Gene
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO47 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer