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Aliases for FBXO47 Gene

Aliases for FBXO47 Gene

  • F-Box Protein 47 2 3 5

External Ids for FBXO47 Gene

Previous GeneCards Identifiers for FBXO47 Gene

  • GC17U900551
  • GC17M034346
  • GC17M037092
  • GC17M032887

Summaries for FBXO47 Gene

GeneCards Summary for FBXO47 Gene

FBXO47 (F-Box Protein 47) is a Protein Coding gene. Diseases associated with FBXO47 include Renal Cell Carcinoma, Papillary, 1.

UniProtKB/Swiss-Prot for FBXO47 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Additional gene information for FBXO47 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO47 Gene

Genomics for FBXO47 Gene

GeneHancer (GH) Regulatory Elements for FBXO47 Gene

Promoters and enhancers for FBXO47 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I038966 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 -0.1 -116 1.5 CTCF RXRA TAF1 MAX REST RAD21 YY1 SP1 ATF3 POLR2A FBXO47 GC17P039017
GH17I038740 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +224.9 224931 3.6 KLF1 PKNOX1 FOXA2 NFIB ZSCAN4 BMI1 ZIC2 ZNF48 ZNF121 GLIS2 C17orf98 PCGF2 MLLT6 FBXO47 PIP4K2B SOCS7 PSMB3 CISD3 LOC100287808 GC17M038732
GH17I038925 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.8 +41.4 41399 2.1 HDAC1 PKNOX1 ARNT ZBTB40 TCF12 ZNF766 ETV6 ATF7 IKZF2 RUNX3 LINC00672 ENSG00000266588 FBXO47 C17orf98 PIP4K2B CWC25 GC17M038934
GH17I038920 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +45.3 45261 3.1 ZFP64 SIN3A ZNF213 PAF1 ZNF202 ZNF654 ZBTB11 ZC3H11A REST ZNF623 ENSG00000265784 MED1 CDK12 SNORA21 LOC105371762 RPL23 FBXO47 C17orf98 CWC25 PIP4K2B
GH17I039013 Enhancer 1.2 Ensembl ENCODE 11.4 -48.3 -48291 3.6 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 FOS ATF7 CAVIN1 TSHZ1 GC17M039013 MED1 CDK12 SNORA21 LOC105371762 FBXO47 RPL23 ARL5C STARD3 CACNB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO47 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO47 gene promoter:

Genomic Locations for FBXO47 Gene

Genomic Locations for FBXO47 Gene
chr17:38,936,278-38,967,486
(GRCh38/hg38)
Size:
31,209 bases
Orientation:
Minus strand
chr17:37,092,685-37,123,655
(GRCh37/hg19)

Genomic View for FBXO47 Gene

Genes around FBXO47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO47 Gene

Proteins for FBXO47 Gene

  • Protein details for FBXO47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MNV8-FBX47_HUMAN
    Recommended name:
    F-box only protein 47
    Protein Accession:
    Q5MNV8
    Secondary Accessions:
    • B2RTZ4

    Protein attributes for FBXO47 Gene

    Size:
    452 amino acids
    Molecular mass:
    51968 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

neXtProt entry for FBXO47 Gene

Post-translational modifications for FBXO47 Gene

No Post-translational modifications

Other Protein References for FBXO47 Gene

No data available for DME Specific Peptides for FBXO47 Gene

Domains & Families for FBXO47 Gene

Gene Families for FBXO47 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO47 Gene

Suggested Antigen Peptide Sequences for FBXO47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO47: view

No data available for UniProtKB/Swiss-Prot for FBXO47 Gene

Function for FBXO47 Gene

Molecular function for FBXO47 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Phenotypes From GWAS Catalog for FBXO47 Gene

genes like me logo Genes that share phenotypes with FBXO47: view

Animal Models for FBXO47 Gene

MGI Knock Outs for FBXO47:

Animal Model Products

CRISPR Products

miRNA for FBXO47 Gene

miRTarBase miRNAs that target FBXO47

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO47 Gene

Localization for FBXO47 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO47 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FBXO47 Gene

Pathways & Interactions for FBXO47 Gene

SuperPathways for FBXO47 Gene

No Data Available

Interacting Proteins for FBXO47 Gene

Gene Ontology (GO) - Biological Process for FBXO47 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO47 Gene

Drugs & Compounds for FBXO47 Gene

No Compound Related Data Available

Transcripts for FBXO47 Gene

mRNA/cDNA for FBXO47 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO47 Gene

F-box protein 47:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO47 Gene

No ASD Table

Relevant External Links for FBXO47 Gene

GeneLoc Exon Structure for
FBXO47
ECgene alternative splicing isoforms for
FBXO47

Expression for FBXO47 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO47 Gene

This gene is overexpressed in Testis (x43.3).

NURSA nuclear receptor signaling pathways regulating expression of FBXO47 Gene:

FBXO47

SOURCE GeneReport for Unigene cluster for FBXO47 Gene:

Hs.549536

mRNA Expression by UniProt/SwissProt for FBXO47 Gene:

Q5MNV8-FBX47_HUMAN
Tissue specificity: Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.
genes like me logo Genes that share expression patterns with FBXO47: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO47 Gene

Orthologs for FBXO47 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO47 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia FBXO47 33 34
  • 91.8 (n)
cow
(Bos Taurus)
Mammalia FBXO47 33 34
  • 90.2 (n)
mouse
(Mus musculus)
Mammalia Fbxo47 33 16 34
  • 86.53 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO47 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo47 33
  • 83.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO47 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO47 33 34
  • 74.19 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO47 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo47 33
  • 62.86 (n)
Species where no ortholog for FBXO47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO47 Gene

ENSEMBL:
Gene Tree for FBXO47 (if available)
TreeFam:
Gene Tree for FBXO47 (if available)

Paralogs for FBXO47 Gene

No data available for Paralogs for FBXO47 Gene

Variants for FBXO47 Gene

Sequence variations from dbSNP and Humsavar for FBXO47 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000032577 -- 38,960,693(-) G/A intron_variant
rs1000058289 -- 38,941,660(-) A/G intron_variant
rs1000097458 -- 38,962,377(-) A/C intron_variant
rs1000297715 -- 38,941,396(-) C/G intron_variant
rs1000315983 -- 38,955,152(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO47 Gene

Variant ID Type Subtype PubMed ID
esv1193917 CNV insertion 17803354
esv2669787 CNV deletion 23128226
esv3640533 CNV loss 21293372
nsv1071382 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159

Variation tolerance for FBXO47 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO47 Gene

Disorders for FBXO47 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO47 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary, 1
  • rccp1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FBXO47

genes like me logo Genes that share disorders with FBXO47: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO47 Gene

Publications for FBXO47 Gene

  1. Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma. (PMID: 15723337) Simon-Kayser B … Bezieau S (Genes, chromosomes & cancer 2005) 2 3 4 58
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for FBXO47 Gene

Sources for FBXO47 Gene

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