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Aliases for FBXO47 Gene

Aliases for FBXO47 Gene

  • F-Box Protein 47 2 3 5

External Ids for FBXO47 Gene

Previous GeneCards Identifiers for FBXO47 Gene

  • GC17U900551
  • GC17M034346
  • GC17M037092
  • GC17M032887

Summaries for FBXO47 Gene

GeneCards Summary for FBXO47 Gene

FBXO47 (F-Box Protein 47) is a Protein Coding gene. Diseases associated with FBXO47 include renal cell carcinoma, papillary.

UniProtKB/Swiss-Prot for FBXO47 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO47 Gene

Genomics for FBXO47 Gene

Regulatory Elements for FBXO47 Gene

Promoters for FBXO47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO47 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO47 Gene

Chromosome:
17
Start:
38,936,278 bp from pter
End:
38,967,486 bp from pter
Size:
31,209 bases
Orientation:
Minus strand

Genomic View for FBXO47 Gene

Genes around FBXO47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO47 Gene

Proteins for FBXO47 Gene

  • Protein details for FBXO47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MNV8-FBX47_HUMAN
    Recommended name:
    F-box only protein 47
    Protein Accession:
    Q5MNV8
    Secondary Accessions:
    • B2RTZ4

    Protein attributes for FBXO47 Gene

    Size:
    452 amino acids
    Molecular mass:
    51968 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

neXtProt entry for FBXO47 Gene

Proteomics data for FBXO47 Gene at MOPED

Post-translational modifications for FBXO47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO47 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXO47

No data available for DME Specific Peptides for FBXO47 Gene

Domains & Families for FBXO47 Gene

Gene Families for FBXO47 Gene

Protein Domains for FBXO47 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MNV8

UniProtKB/Swiss-Prot:

FBX47_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO47: view

Function for FBXO47 Gene

Molecular function for FBXO47 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
genes like me logo Genes that share phenotypes with FBXO47: view

Animal Models for FBXO47 Gene

MGI Knock Outs for FBXO47:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO47 Gene

Localization for FBXO47 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO47 Gene COMPARTMENTS Subcellular localization image for FBXO47 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO47 Gene

Pathways & Interactions for FBXO47 Gene

SuperPathways for FBXO47 Gene

No Data Available

Interacting Proteins for FBXO47 Gene

Gene Ontology (GO) - Biological Process for FBXO47 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO47 Gene

Drugs & Compounds for FBXO47 Gene

No Compound Related Data Available

Transcripts for FBXO47 Gene

mRNA/cDNA for FBXO47 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO47 Gene

F-box protein 47:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO47 Gene

No ASD Table

Relevant External Links for FBXO47 Gene

GeneLoc Exon Structure for
FBXO47
ECgene alternative splicing isoforms for
FBXO47

Expression for FBXO47 Gene

mRNA expression in normal human tissues for FBXO47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO47 Gene

This gene is overexpressed in Testis (x43.3).

SOURCE GeneReport for Unigene cluster for FBXO47 Gene Hs.549536

mRNA Expression by UniProt/SwissProt for FBXO47 Gene

Q5MNV8-FBX47_HUMAN
Tissue specificity: Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.
genes like me logo Genes that share expression patterns with FBXO47: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FBXO47 Gene

Orthologs for FBXO47 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO47 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO47 35
  • 90.2 (n)
  • 87.44 (a)
FBXO47 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO47 35
  • 91.8 (n)
  • 91.35 (a)
FBXO47 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo47 35
  • 86.53 (n)
  • 83.48 (a)
Fbxo47 16
Fbxo47 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO47 35
  • 99.34 (n)
  • 99.34 (a)
FBXO47 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo47 35
  • 83.67 (n)
  • 80.22 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO47 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO47 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO47 35
  • 74.19 (n)
  • 74.12 (a)
FBXO47 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO47 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo47 35
  • 62.86 (n)
  • 61.42 (a)
Species with no ortholog for FBXO47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO47 Gene

ENSEMBL:
Gene Tree for FBXO47 (if available)
TreeFam:
Gene Tree for FBXO47 (if available)

Paralogs for FBXO47 Gene

No data available for Paralogs for FBXO47 Gene

Variants for FBXO47 Gene

Sequence variations from dbSNP and Humsavar for FBXO47 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9906595 - 38,945,127(+) GTTTT(C/T)GGGCA reference, missense
rs1733798 -- 38,968,820(+) tttga(A/G)acaga upstream-variant-2KB
rs1733799 -- 38,968,969(+) tagca(A/G)agatg upstream-variant-2KB
rs1733802 -- 38,959,553(-) gccca(A/G)actgg intron-variant
rs1733803 -- 38,937,879(-) catcc(C/T)ggcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO47 Gene

Variant ID Type Subtype PubMed ID
esv2669787 CNV Deletion 23128226
esv1193917 CNV Insertion 17803354

Variation tolerance for FBXO47 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO47 Gene

HapMap Linkage Disequilibrium report
FBXO47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO47 Gene

Disorders for FBXO47 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO47 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXO47

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO47
genes like me logo Genes that share disorders with FBXO47: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO47 Gene

Publications for FBXO47 Gene

  1. Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma. (PMID: 15723337) Simon-Kayser B. … Bezieau S. (Genes Chromosomes Cancer 2005) 2 3 4 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FBXO47 Gene

Sources for FBXO47 Gene

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