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Aliases for FBXO47 Gene

Aliases for FBXO47 Gene

  • F-Box Protein 47 2 3

External Ids for FBXO47 Gene

Summaries for FBXO47 Gene

GeneCards Summary for FBXO47 Gene

FBXO47 (F-Box Protein 47) is a Protein Coding gene. Diseases associated with FBXO47 include renal cell carcinoma.

UniProtKB/Swiss-Prot for FBXO47 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO47 Gene

Genomics for FBXO47 Gene

Genomic Location for FBXO47 Gene

Start:
38,936,432 bp from pter
End:
38,967,402 bp from pter
Size:
30,971 bases
Orientation:
Minus strand

Genomic View for FBXO47 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO47 Gene

Regulatory Elements for FBXO47 Gene

Proteins for FBXO47 Gene

  • Protein details for FBXO47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MNV8-FBX47_HUMAN
    Recommended name:
    F-box only protein 47
    Protein Accession:
    Q5MNV8
    Secondary Accessions:
    • B2RTZ4

    Protein attributes for FBXO47 Gene

    Size:
    452 amino acids
    Molecular mass:
    51968 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

neXtProt entry for FBXO47 Gene

Proteomics data for FBXO47 Gene at MOPED

Post-translational modifications for FBXO47 Gene

No Post-translational modifications

Other Protein References for FBXO47 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO47 Gene

Domains for FBXO47 Gene

Gene Families for FBXO47 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO47 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FBX47_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q5MNV8
genes like me logo Genes that share domains with FBXO47: view

Function for FBXO47 Gene

Molecular function for FBXO47 Gene

UniProtKB/Swiss-Prot Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Ontology (GO) - Molecular Function for FBXO47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXO47: view

Phenotypes for FBXO47 Gene

MGI mutant phenotypes for FBXO47:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FBXO47: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO47 Gene

Localization for FBXO47 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO47 Gene COMPARTMENTS Subcellular localization image for FBXO47 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FBXO47 Gene

Pathways for FBXO47 Gene

SuperPathways for FBXO47 Gene

No Data Available

Interacting Proteins for FBXO47 Gene

Gene Ontology (GO) - Biological Process for FBXO47 Gene

None

No data available for Pathways by source for FBXO47 Gene

Transcripts for FBXO47 Gene

mRNA/cDNA for FBXO47 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO47 Gene

F-box protein 47:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO47 Gene

No ASD Table

Relevant External Links for FBXO47 Gene

GeneLoc Exon Structure for
FBXO47
ECgene alternative splicing isoforms for
FBXO47

Expression for FBXO47 Gene

mRNA expression in normal human tissues for FBXO47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO47 Gene

This gene is overexpressed in Testis (43.3).

SOURCE GeneReport for Unigene cluster for FBXO47 Gene Hs.549536

mRNA Expression by UniProt/SwissProt for FBXO47 Gene

Q5MNV8-FBX47_HUMAN
Tissue specificity: Widely expressed, with highest levels in kidney, liver and pancreas. Down-regulated in tumors.
genes like me logo Genes that share expressions with FBXO47: view

Orthologs for FBXO47 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO47 36
  • 99.34 (n)
  • 99.34 (a)
FBXO47 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO47 36
  • 90.2 (n)
  • 87.44 (a)
FBXO47 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO47 36
  • 91.8 (n)
  • 91.35 (a)
FBXO47 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo47 36
  • 86.53 (n)
  • 83.48 (a)
Fbxo47 16
Fbxo47 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO47 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO47 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo47 36
  • 83.67 (n)
  • 80.22 (a)
chicken
(Gallus gallus)
Aves FBXO47 36
  • 74.19 (n)
  • 74.12 (a)
FBXO47 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO47 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo47 36
  • 62.86 (n)
  • 61.42 (a)
Species with no ortholog for FBXO47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO47 Gene

ENSEMBL:
Gene Tree for FBXO47 (if available)
TreeFam:
Gene Tree for FBXO47 (if available)

Paralogs for FBXO47 Gene

No data available for Paralogs for FBXO47 Gene

Variants for FBXO47 Gene

Sequence variations from dbSNP and Humsavar for FBXO47 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs594415 -- 38,936,990(-) GGCAG(A/C)CTCAA utr-variant-3-prime
rs1262618 -- 38,950,918(-) CAAAA(A/G)AAATA intron-variant
rs1270620 -- 38,948,331(-) ggagg(C/T)tgaga intron-variant
rs1639928 -- 38,959,563(-) tcact(C/G/T)tgttg intron-variant
rs1639929 -- 38,954,689(-) TCTCA(A/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO47 Gene

Variant ID Type Subtype PubMed ID
esv2669787 CNV Deletion 23128226
esv1193917 CNV Insertion 17803354

Relevant External Links for FBXO47 Gene

HapMap Linkage Disequilibrium report
FBXO47

Disorders for FBXO47 Gene

(1) MalaCards Diseases for FBXO47 Gene

Search for FBXO47 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FBXO47 Gene

genes like me logo Genes that share disorders with FBXO47: view

No data available for UniProtKB/Swiss-Prot for FBXO47 Gene

Publications for FBXO47 Gene

  1. Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma. (PMID: 15723337) Simon-Kayser B. … Bezieau S. (Genes Chromosomes Cancer 2005) 2 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for FBXO47 Gene

Sources for FBXO47 Gene

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