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FBXO46 Gene

protein-coding   GIFtS: 41
GCID: GC19M046213

F-Box Protein 46

(Previous name: F-box only protein 34-like)
(Previous symbol: FBXO34L)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 461 2     20D7-FC42
FBXO34L1 2 3     Fbx462
F-Box Only Protein 34-Like1 3     F-Box Only Protein 462
FBX463 5     

External Ids:    HGNC: 250691   Entrez Gene: 234032   Ensembl: ENSG000001770517   OMIM: 6091175   UniProtKB: Q6PJ613   

Export aliases for FBXO46 gene to outside databases

Previous GC identifers: GC19M050906 GC19M042642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO46 Gene:
Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXO46 Gene:
FBXO46 (F-box protein 46) is a protein-coding gene. Diseases associated with FBXO46 include myotonic dystrophy. An important paralog of this gene is FBXO34.

UniProtKB/Swiss-Prot: FBX46_HUMAN, Q6PJ61
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO46 gene promoter:
         STAT1   Pax-5   AML1a   RREB-1   STAT1beta   CUTL1   Arnt   STAT1alpha   GATA-1   c-Myb   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FBXO46

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO46


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

FBXO46 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO46 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046213:  view genomic region     (about GC identifiers)

Start:
46,213,887 bp from pter      End:
46,234,162 bp from pter
Size:
20,276 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FBX46_HUMAN, Q6PJ61 (See protein sequence)
Recommended Name: F-box only protein 46  
Size: 603 amino acids; 64631 Da
Subunit: Interacts with SKP1 and CUL1 (By similarity)
Caution: The region from 1 to 163 was deduced from the genomic sequence and ESTs by similarity to the mouse
sequence
Sequence caution: Sequence=AAH21978.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH21978.1; Type=Erroneous termination; Positions=604; Note=Translated as stop;

Explore the universe of human proteins at neXtProt for FBXO46: NX_Q6PJ61

Explore proteomics data for FBXO46 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO46 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073938.1  
    ENSEMBL proteins: 
     ENSP00000410007   ENSP00000468336   ENSP00000465591  

    FBXO46 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FBXO46
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    Novus Biologicals FBXO46 Protein
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    Cloud-Clone Corp. Proteins for FBXO46

    FBXO46 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for FBXO46

    FBXO46 Assay Products:

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    Cloud-Clone Corp. ELISAs for FBXO46
    Cloud-Clone Corp. CLIAs for FBXO46


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q6PJ61

    ProtoNet protein and cluster: Q6PJ61

    UniProtKB/Swiss-Prot: FBX46_HUMAN, Q6PJ61
    Similarity: Contains 1 F-box domain


    FBXO46 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX46_HUMAN, Q6PJ61
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19159283
         
    FBXO46 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO46
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO46
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FBXO46 (see all 19):
    hsa-miR-185* hsa-miR-513a-5p hsa-miR-340 hsa-miR-520a-5p hsa-miR-3190 hsa-miR-342-5p hsa-miR-22 hsa-miR-2114
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO46

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FBXO46

    Clone
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    GenScript: all cDNA clones in your preferred vector: FBXO46 (NM_001080469)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO46
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO46

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO46


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO46
    Interactions:

        Search GeneGlobe Interaction Network for FBXO46

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FBXO46 (Q6PJ611, 3 ENSP000004100074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 3, ENSP000002314874EBI-2322982,EBI-307486 I2D: score=1 STRING: ENSP00000231487
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO46 (FBX46)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FBXO46 gene: 
    NM_001080469.1  

    Unigene Cluster for FBXO46:

    F-box protein 46
    Hs.128702  [show with all ESTs]
    Unigene Representative Sequence: NM_001080469
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317683(uc002pcy.3 uc002pcz.3) ENST00000586899 ENST00000591686

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXO46 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO46 (see all 19):
    hsa-miR-185* hsa-miR-513a-5p hsa-miR-340 hsa-miR-520a-5p hsa-miR-3190 hsa-miR-342-5p hsa-miR-22 hsa-miR-2114
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXO46
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO46
    Clone
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    OriGene clones in human, mouse for FBXO46 (see all 7)
    OriGene ORF clones in mouse, rat for FBXO46
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO46 (NM_001080469)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO46
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO46
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO46
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO46
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO46
      QuantiFast Probe-based Assays in human, mouse, rat FBXO46

    Additional mRNA sequence: 

    BC008046.2 BC013570.1 BC021978.2 BC046245.1 Y10936.1 

    2 DOTS entries:

    DT.99990265  DT.86851596 

    Selected AceView cDNA sequences (see all 103):

    BM978032 BF514285 BF116252 BC013570 AA035309 BF514588 BE674624 AA035310 
    AI341533 BE880418 CR594072 AL042641 BF514261 BQ068066 CA946698 AA809890 
    AW513922 AW236767 AW301578 BE884228 BU728511 BF448391 CB961159 AW196280 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO46 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTTTAAG
    FBXO46 Expression
    About this image

    FBXO46 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO46 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128702
        Custom PCR Arrays for FBXO46
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO46
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO46

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO46 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo461 , 5 F-box protein 461, 5 83.59(n)1
    91.37(a)1
      7 (9.46 cM)5
    2438671  NM_175530.31  NP_780739.11 
     191198595 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO466
    F-box protein 46
    57(a)
    1 ↔ 1
    AAWZ02037989(1972-3984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.129662 Xenopus laevis transcribed sequence with weak similarity more 73.98(n)    BJ097782.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-114g7.41 si:dkey-114g7.4 59.18(n)
    55.96(a)
      562515  NM_001082831.1  NP_001076300.1 


    ENSEMBL Gene Tree for FBXO46 (if available)
    TreeFam Gene Tree for FBXO46 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO46 gene
    FBXO342  

    FBXO46 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO46 (see all 437)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs621117311,2
    C--46213416(+) GAGGCG/AGAGCT 1 -- ds50015Minor allele frequency- A:0.11NA WA CSA 9
    rs762421661,2
    C,F--46213538(+) ACCTGT/CAGAAA 1 -- ds50011Minor allele frequency- C:0.38EA 120
    rs346741601,2
    C,F--46213550(+) CCCAGC/TTGCTT 1 -- ds50017Minor allele frequency- T:0.05NA WA CSA 248
    rs575436331,2
    C,F--46213552(+) CAGCTG/TCTTGG 1 -- ds50015Minor allele frequency- T:0.14NA WA CSA EA 246
    rs1870797961,2
    --46213600(+) TGCTGC/TAGTGA 1 -- ds50010--------
    rs713387961,2
    C--46213684(+) AAAAA-/A/AA  
            
    TCTTG
    1 -- ds50011NA 2
    rs1914686921,2
    --46213782(+) CTAGGA/GATCCC 1 -- ds50010--------
    rs1442092741,2
    --46213859(+) CTTCAC/TAACAC 1 -- ds50010--------
    rs1465335491,2
    C--46213917(+) GACCAA/GTTCAA 1 -- ut310--------
    rs1409345051,2
    --46213994(+) AAACAA/GAGAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXO46 (46213887 - 46234162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FBXO46:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3954n71CNV Loss21882294
    dgv3955n71CNV Loss21882294
    esv22434CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO46
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO46

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609117    OMIM disorders: --

    1 disease for FBXO46:    
    About MalaCards
    myotonic dystrophy


    FBXO46 for disorders           About GeneDecksing


    Export disorders for FBXO46 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO46 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with FBXO46)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat. (PubMed id 9585442)1, 3 Alwazzan M.... Brook J.D. (Mamm. Genome 1998)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (PLoS ONE 2013)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (J. Proteome Res. 2009)
    9. A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. (PubMed id 18247557)1 Jones J....Huang L. (J. Proteome Res. 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23403 HGNC: 25069 AceView: FBXO46 Ensembl:ENSG00000177051 euGenes: HUgn23403
    ECgene: FBXO46 H-InvDB: FBXO46

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO46 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO46 gene:
    Search GeneIP for patents involving FBXO46

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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