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Aliases for FBXO46 Gene

Aliases for FBXO46 Gene

  • F-Box Protein 46 2 3 5
  • F-Box Only Protein 34-Like 2 4
  • FBXO34L 3 4
  • Fbx46 3 4
  • 20D7-FC4 3

External Ids for FBXO46 Gene

Previous HGNC Symbols for FBXO46 Gene

  • FBXO34L

Previous GeneCards Identifiers for FBXO46 Gene

  • GC19M050906
  • GC19M046213
  • GC19M042642

Summaries for FBXO46 Gene

Entrez Gene Summary for FBXO46 Gene

  • Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO46 Gene

FBXO46 (F-Box Protein 46) is a Protein Coding gene. An important paralog of this gene is FBXO34.

UniProtKB/Swiss-Prot for FBXO46 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO46 Gene

Genomics for FBXO46 Gene

Regulatory Elements for FBXO46 Gene

Promoters for FBXO46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO46 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO46 Gene

Chromosome:
19
Start:
45,710,629 bp from pter
End:
45,730,904 bp from pter
Size:
20,276 bases
Orientation:
Minus strand

Genomic View for FBXO46 Gene

Genes around FBXO46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO46 Gene

Proteins for FBXO46 Gene

  • Protein details for FBXO46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJ61-FBX46_HUMAN
    Recommended name:
    F-box only protein 46
    Protein Accession:
    Q6PJ61

    Protein attributes for FBXO46 Gene

    Size:
    603 amino acids
    Molecular mass:
    64631 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH21978.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21978.1; Type=Erroneous termination; Positions=604; Note=Translated as stop.; Evidence={ECO:0000305};

neXtProt entry for FBXO46 Gene

Proteomics data for FBXO46 Gene at MOPED

Post-translational modifications for FBXO46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO46 Gene

Domains & Families for FBXO46 Gene

Gene Families for FBXO46 Gene

Protein Domains for FBXO46 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PJ61

UniProtKB/Swiss-Prot:

FBX46_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO46: view

Function for FBXO46 Gene

Molecular function for FBXO46 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes for FBXO46 Gene

genes like me logo Genes that share phenotypes with FBXO46: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO46 Gene

Localization for FBXO46 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO46 Gene COMPARTMENTS Subcellular localization image for FBXO46 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO46 Gene

Pathways & Interactions for FBXO46 Gene

SuperPathways for FBXO46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO46 Gene

Drugs & Compounds for FBXO46 Gene

No Compound Related Data Available

Transcripts for FBXO46 Gene

mRNA/cDNA for FBXO46 Gene

Unigene Clusters for FBXO46 Gene

F-box protein 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO46 Gene

No ASD Table

Relevant External Links for FBXO46 Gene

GeneLoc Exon Structure for
FBXO46
ECgene alternative splicing isoforms for
FBXO46

Expression for FBXO46 Gene

mRNA expression in normal human tissues for FBXO46 Gene

Protein differential expression in normal tissues from HIPED for FBXO46 Gene

This gene is overexpressed in Fetal Liver (31.9) and Blymphocyte (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO46 Gene



SOURCE GeneReport for Unigene cluster for FBXO46 Gene Hs.128702

genes like me logo Genes that share expression patterns with FBXO46: view

Protein tissue co-expression partners for FBXO46 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO46 Gene

Orthologs for FBXO46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO46 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO46 35
  • 88.68 (n)
  • 94.59 (a)
dog
(Canis familiaris)
Mammalia FBXO46 35
  • 88.89 (n)
  • 96.02 (a)
FBXO46 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo46 35
  • 83.59 (n)
  • 91.37 (a)
Fbxo46 16
Fbxo46 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO46 35
  • 98.59 (n)
  • 98.35 (a)
FBXO46 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo46 35
  • 84.26 (n)
  • 90.86 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO46 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO46 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12966 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-114g7.4 35
  • 59.18 (n)
  • 55.96 (a)
FBXO46 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10603 36
  • 17 (a)
OneToMany
Species with no ortholog for FBXO46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO46 Gene

ENSEMBL:
Gene Tree for FBXO46 (if available)
TreeFam:
Gene Tree for FBXO46 (if available)

Paralogs for FBXO46 Gene

Paralogs for FBXO46 Gene

genes like me logo Genes that share paralogs with FBXO46: view

Variants for FBXO46 Gene

Sequence variations from dbSNP and Humsavar for FBXO46 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs15361 -- 45,710,747(-) ttttt(G/T)tttgt utr-variant-3-prime
rs1055217 -- 45,711,577(-) GGCAG(C/G)ATTGA utr-variant-3-prime
rs1055220 -- 45,711,039(-) AGGGG(A/G)GCAGA utr-variant-3-prime
rs3837965 -- 45,711,033(+) TTTTT(G/T)TCTGC utr-variant-3-prime
rs3760842 -- 45,713,768(+) TTTGA(A/G)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO46 Gene

Variant ID Type Subtype PubMed ID
dgv3954n71 CNV Loss 21882294
dgv3955n71 CNV Loss 21882294
esv22434 CNV Loss 19812545

Variation tolerance for FBXO46 Gene

Residual Variation Intolerance Score: 9.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO46 Gene

HapMap Linkage Disequilibrium report
FBXO46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO46 Gene

Disorders for FBXO46 Gene

Relevant External Links for FBXO46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO46

No disorders were found for FBXO46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO46 Gene

Publications for FBXO46 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat. (PMID: 9585442) Alwazzan M. … Brook J.D. (Mamm. Genome 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. (PMID: 23319600) Jeong Y.T. … Pagano M. (J. Cell Biol. 2013) 3
  5. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PMID: 23658844) Lockwood W.W. … Beverly L.J. (PLoS ONE 2013) 3

Products for FBXO46 Gene

Sources for FBXO46 Gene

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