FBXO46 Gene
protein-coding GIFtS: 43
GCID: GC19M046213
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F-box protein 46(Previous name: F-box only protein 34-like )
(Previous symbol: FBXO34L)
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Aliases
for FBXO46 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box Protein 461 2 | | F-Box Only Protein 34-Like1 3 | | FBXO34L1 2 3 | | FBX463 5 | | 20D7-FC41 2 | | F-Box Only Protein 462 | | Fbx461 2 | | |
Export aliases for FBXO46 gene to outside databasesPrevious GC identifers: GC19M050906 GC19M042642 |
Summaries
for FBXO46 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXO46:
Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FBX46_HUMAN, Q6PJ61Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
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Genomic Views
for FBXO46 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXO46 gene promoter:
STAT1 Pax-5 AML1a RREB-1 STAT1beta CUTL1 Arnt STAT1alpha GATA-1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO46
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO46 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.3FBXO46 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M046213: view genomic region
(about GC identifiers)
Start:
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46,213,887 bp from pter |
End:
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46,234,162 bp from pter |
Size:
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20,276 bases |
Orientation:
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minus strand |
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Proteins
for FBXO46 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBX46_HUMAN, Q6PJ61 (See
protein sequence)Recommended Name: F-box only protein 46 Size: 603 amino acids; 64631 Da
Subunit: Interacts with SKP1 and CUL1 (By similarity)
Caution: The region from 1 to 163 was deduced from the genomic sequence and ESTs by similarity to the mouse sequence
Sequence caution: Sequence=AAH21978.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH21978.1; Type=Erroneous termination; Positions=604; Note=Translated as stop;Explore the universe of human proteins at neXtProt for FBXO46: NX_Q6PJ61
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PJ61
FBXO46 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073938.1
ENSEMBL proteins: ENSP00000410007 ENSP00000468336 ENSP00000465591
Human Recombinant Protein Products:
FBXO46 Antibody Products:
Assay Products for FBXO46: |
Protein
Domains /
Families
for FBXO46 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO46 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6PJ61ProtoNet protein and cluster: Q6PJ61 UniProtKB/Swiss-Prot: FBX46_HUMAN, Q6PJ61Similarity: Contains 1 F-box domain |
Function
for FBXO46 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBX46_HUMAN, Q6PJ61Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO46 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO46 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
FBXO46 for ontologies About GeneDecksing
|
Pathways & Interactions
for FBXO46 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO46
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FBXO46 (Q6PJ611, 3 ENSP000004100074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FBXO46 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXO46
Search CenterWatch for drugs/clinical trials and news about FBXO46 / FBX46
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Transcripts
for FBXO46 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXO46 gene: NM_001080469.1 Unigene Cluster for FBXO46: F-box protein 46 Hs.128702 [show with all ESTs]Unigene Representative Sequence: NM_0010804693 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317683(uc002pcy.3 uc002pcz.3) ENST00000586899 ENST00000591686
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO46 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO46 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXO46 (NM_001080469) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO46 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO46 |
Additional cDNA sequence: BC008046.2 BC013570.1 BC021978.2 BC046245.1 Y10936.1 2 DOTS entries: DT.99990265 DT.86851596 24/103 AceView cDNA sequences (see all 103): BF514588 BQ068066 BC013570 CA946698 AL042641 BF514261 AA035310 AA035309 BE880418 BF514285 AI341533 CR594072 BE674624 AW236767 AW301578 BM978032 BF116252 AW513922 AA809890 AI912656 BX102002 BE349580 AL042642 AI273288
GeneLoc Exon Structure
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Expression
for FBXO46 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO46 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTTTAAG
About this image
See FBXO46 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO46
SOURCE GeneReport for Unigene cluster: Hs.128702
SABiosciences Custom PCR Arrays for FBXO46
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO46
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO46 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO46 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO46 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO46 |
Orthologs
for FBXO46 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FBXO46 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for FBXO46 (if available)
TreeFam Gene Tree for FBXO46 (if available) |
Paralogs
for FBXO46 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXO46 gene
- FBXO342
FBXO46 for paralogs About GeneDecksing
|
Genomic Variants
for FBXO46 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXO46 (46213887 - 46234162 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FBXO46
1 Indel: 73387 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO46 |
|
Disorders
/ Diseases
for FBXO46 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXO46 for disorders About GeneDecksing
OMIM gene information: 609117
OMIM disorders: --
1  disease for FBXO46: About MalaCardsmyotonic dystrophy
Export disorders for FBXO46 gene to outside databases
|
Publications
for FBXO46 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO46 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FBXO46) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat. (PubMed id 9585442)1, 3 Alwazzan M.... Brook J.D. (1998)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (2009)
- A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. (PubMed id 18247557)1 Jones J....Huang L. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
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External Searches for FBXO46 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FBXO46 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO46 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXO46 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXO46 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FBXO46 gene:
Search GeneIP for patents involving FBXO46
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXO46 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO46 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO46 |
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