FBXO45 Gene
protein-coding GIFtS: 46
GCID: GC03P196295
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|
F-box protein 45
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Aliases for FBXO45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| F-Box Protein 451 2 | | Fbx451 2 | | F-Box Only Protein 452 3 | | HFbxo451 | | FBX453 5 | | F-Box/SPRY Domain-Containing Protein 12 |
Export aliases for FBXO45 gene to outside databasesPrevious GC identifers: GC00U915701 GC03P197784 GC03P193593 |
Summaries for FBXO45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for FBXO45: Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (summary by Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM,Jan 2011) UniProtKB/Swiss-Prot: FBSP1_HUMAN, P0C2W1Function: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axonpathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at matureneurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (Bysimilarity). Specifically recognizes TP73, promoting its ubiquitination and degradation
|
Genomic Views for FBXO45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXO45 gene promoter: Pax-5 AML1a SREBP-1c STAT5A GATA-1 SREBP-1b AREB6 SREBP-1a Pax-4a Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO45
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO45 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29FBXO45 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P196295: view genomic region
(about GC identifiers)
Start:
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196,295,482 bp from pter |
End:
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196,315,930 bp from pter |
Size:
|
20,449 bases |
Orientation:
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plus strand |
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Proteins for FBXO45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: FBSP1_HUMAN, P0C2W1 (See
protein sequence)Recommended Name: F-box/SPRY domain-containing protein 1 Size: 286 amino acids; 30633 Da
Subunit: Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein)complex (By similarity). Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to TP73 ubiquitinationand degradation by proteasome. Interacts (via SRY domain) with UNC13A; leading to degradation of UNC13A by theproteasome (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse,presynaptic cell membrane (By similarity)
Secondary accessions: A6NF90 D3DXB5Explore the universe of human proteins at neXtProt for FBXO45: NX_P0C2W1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C2W1 FBXO45 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_001099043.1 ENSEMBL proteins: ENSP00000389868 ENSP00000310332 Human Recombinant Protein Products for FBXO45:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
FBXO45 for ontologies About GeneDecksing
FBXO45 Antibody Products: Assay Products for FBXO45: |
Protein
Domains / Families for FBXO45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO45 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0C2W1ProtoNet protein and cluster: P0C2W1 UniProtKB/Swiss-Prot: FBSP1_HUMAN, P0C2W1Similarity: Belongs to the FBXO45/Fsn familySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 F-box domain |
Function for FBXO45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: FBSP1_HUMAN, P0C2W1Function: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axonpathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at matureneurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (Bysimilarity). Specifically recognizes TP73, promoting its ubiquitination and degradationInduction: Down-regulated in response to DNA-damage Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FBXO45 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for FBXO45: 7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fbxo45):
FBXO45 for phenotypes About GeneDecksing
Animal Models: Mouse knock-out Fbxo45tm1Kei for FBXO45
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO45 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO45 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO45 |
|
Pathways & Interactions for FBXO45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: FBSP1_HUMAN, P0C2W1Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO45
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
 5/6 Interacting proteins for FBXO45 (P0C2W13 ENSP000003103324) via UniProtKB, MINT, STRING, and/or I2D (see all 6) About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006974 | response to DNA damage stimulus |
IDA | 19581926 | | GO:0007399 | nervous system development |
IEA | -- | | GO:0016567 | protein ubiquitination |
ISS | -- | | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
IDA | 19581926 | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
ISS | -- |
FBXO45 for ontologies About GeneDecksing
|
Drugs & Compounds for FBXO45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FBXO45 Search CenterWatch for drugs/clinical trials and news about FBXO45 / FBSP1 
|
Transcripts for FBXO45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FBXO45 gene: NM_001105573.1 Unigene Cluster for FBXO45: F-box protein 45 Hs.169815 [show with all ESTs]Unigene Representative Sequence: NM_0011055732 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000440469 ENST00000311630(uc010iai.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO45 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO45 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXO45 (NM_001105573) | |  | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK025697.1 6 DOTS entries: DT.95191844 DT.100740749 DT.106582 DT.120905800 DT.445275 DT.97773304 24/139 AceView cDNA sequences (see all 139): AA301250 AI335755 AI435795 BU521386 BQ422364 AA287417 BU620966 AA977754 BU754391 BQ188291 BF590021 AI637773 BM758584 BQ027632 CD677723 AI656790 CA445163 BQ007088 AA670305 AI653095 BU619599 BF477808 BF057293 CF140200 GeneLoc Exon Structure
|
Expression for FBXO45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO45 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CAGATGTGGA
 About this image See FBXO45 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBXO45
SOURCE GeneReport for Unigene cluster: Hs.169815 SABiosciences Custom PCR Arrays for FBXO45
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO45 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FBXO45 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO45 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO45 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO45 |
Orthologs for FBXO45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXO45 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
FBXO451 |
F-box protein 45 |
78.77(n) 88.61(a) |
  |
770111 XM_001232840.2 XP_001232841.2 |
lizard (Anolis carolinensis) |
Reptilia |
FBXO456 |
-- |
92(a) |
1 ↔ 1 |
3(30755274-30760878) |
African clawed frog (Xenopus laevis) |
Amphibia |
3g27-prov2 |
cyclin-like F-box and SPla/RYanodine receptor SPRY more |
80.69(n) |
  |
BC044070.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc658752 |
hypothetical protein MGC65875 |
76.11(n) |
  |
393567 BC056756.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Fsn1 |
CG4643-PA |
66.53(n) 71.6(a) |
  |
36460 NM_137005.1 NP_610849.1 |
worm (Caenorhabditis elegans) |
Secernentea |
fsn-11 |
Protein FSN-1 |
52.32(n) 55.38(a) |
  |
175667 NM_065645.4 NP_498046.1 |
ENSEMBL Gene Tree for FBXO45 (if available) TreeFam Gene Tree for FBXO45 (if available)  |
Paralogs for FBXO45 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FBXO45 gene
- SPSB22 SPSB12 SPSB42
3 SIMAP similar genes for FBXO45 using alignment to 2 protein entries: FBSP1_HUMAN (see all proteins):SPSB4 SPSB2 SPSB1
FBXO45 for paralogs About GeneDecksing
|
Genomic Variants for FBXO45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXO45 (196295482 - 196315930 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for FBXO45 1 CNV: 4368 2 Inversions: 37243 0568  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO45 |
|
Disorders
/ Diseases for FBXO45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXO45 for disorders About GeneDecksing
OMIM gene information: 609112
OMIM disorders: --
1 disease for FBXO45: About MalaCardsneuronitis Human Genome Epidemiology (HuGE) Navigator: FBXO45 (1 document) Export disorders for FBXO45 gene to outside databases
|
Publications for FBXO45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO45 gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with FBXO45) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The F-box protein FBXO45 promotes the proteasome-depe ndent degradation of p73. (PubMed id 19581926)1, 2 Peschiaroli A....Melino G. (2009)
- Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1, 2 Jin J....Harper J.W. (2004)
- Characterization of estrogen-induced F-box protein FBXO45. (PubMed id 16012741)1, 9 Yoshida K. (2005)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. (PubMed id 19398581)1 Saiga T....Nakayama K.I. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for FBXO45 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FBXO45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXO45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FBXO45 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXO45 gene: Search GeneIP for patents involving FBXO45
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FBXO45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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