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Aliases for FBXO45 Gene

Aliases for FBXO45 Gene

  • F-Box Protein 45 2 3 5
  • F-Box Only Protein 45 3 4
  • HFbxo45 3 4
  • Fbx45 3 4

External Ids for FBXO45 Gene

Previous GeneCards Identifiers for FBXO45 Gene

  • GC00U915701
  • GC03P197784
  • GC03P196295
  • GC03P193593

Summaries for FBXO45 Gene

Entrez Gene Summary for FBXO45 Gene

  • Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]

GeneCards Summary for FBXO45 Gene

FBXO45 (F-Box Protein 45) is a Protein Coding gene. Diseases associated with FBXO45 include chromosome 3q29 microduplication syndrome. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot for FBXO45 Gene

  • Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO45 Gene

Genomics for FBXO45 Gene

Regulatory Elements for FBXO45 Gene

Promoters for FBXO45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO45 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO45 Gene

Chromosome:
3
Start:
196,568,611 bp from pter
End:
196,589,059 bp from pter
Size:
20,449 bases
Orientation:
Plus strand

Genomic View for FBXO45 Gene

Genes around FBXO45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO45 Gene

Proteins for FBXO45 Gene

  • Protein details for FBXO45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C2W1-FBSP1_HUMAN
    Recommended name:
    F-box/SPRY domain-containing protein 1
    Protein Accession:
    P0C2W1
    Secondary Accessions:
    • A6NF90
    • D3DXB5

    Protein attributes for FBXO45 Gene

    Size:
    286 amino acids
    Molecular mass:
    30633 Da
    Quaternary structure:
    • Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein) complex (By similarity). Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to TP73 ubiquitination and degradation by proteasome. Interacts (via SRY domain) with UNC13A; leading to degradation of UNC13A by the proteasome (By similarity).

neXtProt entry for FBXO45 Gene

Proteomics data for FBXO45 Gene at MOPED

Post-translational modifications for FBXO45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO45 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXO45

No data available for DME Specific Peptides for FBXO45 Gene

Domains & Families for FBXO45 Gene

Gene Families for FBXO45 Gene

Protein Domains for FBXO45 Gene

Suggested Antigen Peptide Sequences for FBXO45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C2W1

UniProtKB/Swiss-Prot:

FBSP1_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the FBXO45/Fsn family.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 F-box domain.
Family:
  • Belongs to the FBXO45/Fsn family.
genes like me logo Genes that share domains with FBXO45: view

Function for FBXO45 Gene

Molecular function for FBXO45 Gene

UniProtKB/Swiss-Prot Function:
Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to DNA-damage.
genes like me logo Genes that share phenotypes with FBXO45: view

Animal Models for FBXO45 Gene

MGI Knock Outs for FBXO45:

Animal Model Products

miRNA for FBXO45 Gene

miRTarBase miRNAs that target FBXO45

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO45 Gene

Localization for FBXO45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO45 Gene

Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO45 Gene COMPARTMENTS Subcellular localization image for FBXO45 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 2
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FBXO45 Gene

Pathways & Interactions for FBXO45 Gene

SuperPathways for FBXO45 Gene

No Data Available

UniProtKB/Swiss-Prot P0C2W1-FBSP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXO45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0016567 protein ubiquitination IEA,ISS --
GO:0021800 cerebral cortex tangential migration IEA --
GO:0021960 anterior commissure morphogenesis IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA,ISS --
genes like me logo Genes that share ontologies with FBXO45: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO45 Gene

Drugs & Compounds for FBXO45 Gene

No Compound Related Data Available

Transcripts for FBXO45 Gene

mRNA/cDNA for FBXO45 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO45 Gene

F-box protein 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO45 Gene

No ASD Table

Relevant External Links for FBXO45 Gene

GeneLoc Exon Structure for
FBXO45
ECgene alternative splicing isoforms for
FBXO45

Expression for FBXO45 Gene

mRNA expression in normal human tissues for FBXO45 Gene

Protein differential expression in normal tissues from HIPED for FBXO45 Gene

This gene is overexpressed in Pancreatic juice (52.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO45 Gene



SOURCE GeneReport for Unigene cluster for FBXO45 Gene Hs.169815

genes like me logo Genes that share expression patterns with FBXO45: view

Protein tissue co-expression partners for FBXO45 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO45 Gene

Orthologs for FBXO45 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO45 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO45 36
  • 97 (a)
OneToOne
FBXO45 35
  • 96.39 (n)
  • 99.2 (a)
dog
(Canis familiaris)
Mammalia FBXO45 35
  • 95.18 (n)
  • 97.19 (a)
FBXO45 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo45 36
  • 95 (a)
OneToOne
Fbxo45 16
Fbxo45 35
  • 93.44 (n)
  • 99.2 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO45 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo45 35
  • 93.46 (n)
  • 99.02 (a)
chicken
(Gallus gallus)
Aves FBXO45 35
  • 82.73 (n)
  • 94.38 (a)
FBXO45 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO45 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia 3g27-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo45 35
  • 78.57 (n)
  • 90.31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14037 35
zebrafish
(Danio rerio)
Actinopterygii fbxo45 36
  • 78 (a)
OneToOne
fbxo45 35
  • 74.73 (n)
  • 87.1 (a)
zgc65875 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012460 35
  • 61.13 (n)
  • 66.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fsn 36
  • 69 (a)
OneToOne
Fsn 35
  • 66.53 (n)
  • 71.6 (a)
worm
(Caenorhabditis elegans)
Secernentea fsn-1 35
  • 52.69 (n)
  • 56.05 (a)
fsn-1 36
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.980 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6685 36
  • 61 (a)
OneToOne
Species with no ortholog for FBXO45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO45 Gene

ENSEMBL:
Gene Tree for FBXO45 (if available)
TreeFam:
Gene Tree for FBXO45 (if available)

Paralogs for FBXO45 Gene

Paralogs for FBXO45 Gene

(3) SIMAP similar genes for FBXO45 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXO45: view

Variants for FBXO45 Gene

Sequence variations from dbSNP and Humsavar for FBXO45 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs923065 -- 196,582,001(+) CTCAG(A/G)GATTT intron-variant
rs923066 -- 196,582,010(+) ttggg(A/C)agtta intron-variant
rs6763065 -- 196,587,160(+) TACTA(C/T)GGTCT utr-variant-3-prime
rs6791472 -- 196,580,572(+) cacct(A/G)ccttg intron-variant
rs6583322 -- 196,576,790(+) ATTGT(A/G)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO45 Gene

Variant ID Type Subtype PubMed ID
dgv5375n71 CNV Gain 21882294
nsv829828 CNV Loss 17160897

Variation tolerance for FBXO45 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO45 Gene

HapMap Linkage Disequilibrium report
FBXO45
Human Gene Mutation Database (HGMD)
FBXO45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO45 Gene

Disorders for FBXO45 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO45 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 3q29 microduplication syndrome
  • 3q29 microduplication
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXO45

Human Genome Epidemiology (HuGE) Navigator
FBXO45
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO45
genes like me logo Genes that share disorders with FBXO45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO45 Gene

Publications for FBXO45 Gene

  1. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. (PMID: 19581926) Peschiaroli A. … Melino G. (Oncogene 2009) 3 4 67
  2. Characterization of estrogen-induced F-box protein FBXO45. (PMID: 16012741) Yoshida K. (Oncol. Rep. 2005) 3 23
  3. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  4. Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation. (PMID: 25143387) Chung F.Z. … Elenitoba-Johnson K.S. (J. Biol. Chem. 2014) 3
  5. Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival. (PMID: 24992930) Chen X. … Elenitoba-Johnson K.S. (Cell Death Differ. 2014) 3

Products for FBXO45 Gene

Sources for FBXO45 Gene

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