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Aliases for FBXO45 Gene

Aliases for FBXO45 Gene

  • F-Box Protein 45 2 3
  • Fbx45 3 4 6
  • F-Box Only Protein 45 3 4
  • HFbxo45 3 4
  • F-Box/SPRY Domain-Containing Protein 1 3

External Ids for FBXO45 Gene

Summaries for FBXO45 Gene

Entrez Gene Summary for FBXO45 Gene

  • Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]

GeneCards Summary for FBXO45 Gene

FBXO45 (F-Box Protein 45) is a Protein Coding gene. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot for FBXO45 Gene

  • Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO45 Gene

Genomics for FBXO45 Gene

Genomic Location for FBXO45 Gene

Start:
196,568,611 bp from pter
End:
196,589,059 bp from pter
Size:
20,449 bases
Orientation:
Plus strand

Genomic View for FBXO45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO45 Gene

Regulatory Elements for FBXO45 Gene

Proteins for FBXO45 Gene

  • Protein details for FBXO45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C2W1-FBSP1_HUMAN
    Recommended name:
    F-box/SPRY domain-containing protein 1
    Protein Accession:
    P0C2W1
    Secondary Accessions:
    • A6NF90
    • D3DXB5

    Protein attributes for FBXO45 Gene

    Size:
    286 amino acids
    Molecular mass:
    30633 Da
    Quaternary structure:
    • Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein) complex (By similarity). Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to TP73 ubiquitination and degradation by proteasome. Interacts (via SRY domain) with UNC13A; leading to degradation of UNC13A by the proteasome (By similarity).

neXtProt entry for FBXO45 Gene

Proteomics data for FBXO45 Gene at MOPED

Post-translational modifications for FBXO45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO45 Gene

Domains for FBXO45 Gene

Gene Families for FBXO45 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO45 Gene

UniProtKB/Swiss-Prot:

FBSP1_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • P0C2W1
  • Contains 1 F-box domain.:
    • P0C2W1
Family:
  • Belongs to the FBXO45/Fsn family.:
    • P0C2W1
genes like me logo Genes that share domains with FBXO45: view

Function for FBXO45 Gene

Molecular function for FBXO45 Gene

UniProtKB/Swiss-Prot Function: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.
UniProtKB/Swiss-Prot Induction: Down-regulated in response to DNA-damage.

Gene Ontology (GO) - Molecular Function for FBXO45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19581926
genes like me logo Genes that share ontologies with FBXO45: view
genes like me logo Genes that share phenotypes with FBXO45: view

Animal Models for FBXO45 Gene

MGI Knock Outs for FBXO45:

miRNA for FBXO45 Gene

miRTarBase miRNAs that target FBXO45

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FBXO45 Gene

Localization for FBXO45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO45 Gene

Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO45 Gene COMPARTMENTS Subcellular localization image for FBXO45 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
GO:0042734 presynaptic membrane IEA --
GO:0045202 synapse --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with FBXO45: view

Pathways for FBXO45 Gene

SuperPathways for FBXO45 Gene

No Data Available

UniProtKB/Swiss-Prot P0C2W1-FBSP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 19581926
GO:0016567 protein ubiquitination ISS --
GO:0021799 cerebral cortex radially oriented cell migration IEA --
GO:0021800 cerebral cortex tangential migration IEA --
genes like me logo Genes that share ontologies with FBXO45: view

No data available for Pathways by source for FBXO45 Gene

Transcripts for FBXO45 Gene

mRNA/cDNA for FBXO45 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO45 Gene

F-box protein 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO45 Gene

No ASD Table

Relevant External Links for FBXO45 Gene

GeneLoc Exon Structure for
FBXO45
ECgene alternative splicing isoforms for
FBXO45

Expression for FBXO45 Gene

mRNA expression in normal human tissues for FBXO45 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO45 Gene

SOURCE GeneReport for Unigene cluster for FBXO45 Gene Hs.169815

genes like me logo Genes that share expressions with FBXO45: view

Orthologs for FBXO45 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO45 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO45 36
  • 96.39 (n)
  • 99.2 (a)
FBXO45 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO45 36
  • 95.18 (n)
  • 97.19 (a)
FBXO45 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo45 36
  • 93.44 (n)
  • 99.2 (a)
Fbxo45 16
Fbxo45 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO45 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo45 36
  • 93.46 (n)
  • 99.02 (a)
chicken
(Gallus gallus)
Aves FBXO45 36
  • 82.73 (n)
  • 94.38 (a)
FBXO45 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO45 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia 3g27-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo45 36
  • 78.57 (n)
  • 90.31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14037 36
zebrafish
(Danio rerio)
Actinopterygii fbxo45 36
  • 74.73 (n)
  • 87.1 (a)
fbxo45 37
  • 78 (a)
OneToOne
zgc65875 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012460 36
  • 61.13 (n)
  • 66.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fsn 36
  • 66.53 (n)
  • 71.6 (a)
Fsn 37
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fsn-1 36
  • 52.69 (n)
  • 56.05 (a)
fsn-1 37
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.980 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6685 37
  • 61 (a)
OneToOne
Species with no ortholog for FBXO45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO45 Gene

ENSEMBL:
Gene Tree for FBXO45 (if available)
TreeFam:
Gene Tree for FBXO45 (if available)

Paralogs for FBXO45 Gene

Paralogs for FBXO45 Gene

Selected SIMAP similar genes for FBXO45 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXO45: view

Variants for FBXO45 Gene

Sequence variations from dbSNP and Humsavar for FBXO45 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs923065 -- 196,582,001(+) CTCAG(A/G)GATTT intron-variant
rs923066 -- 196,582,010(+) ttggg(A/C)agtta intron-variant
rs1872353 -- 196,586,080(+) TGAAA(C/T)TATAT utr-variant-3-prime
rs2014220 -- 196,585,253(+) TCTAA(A/G)AAAGT utr-variant-3-prime
rs2341337 -- 196,582,865(-) TCACC(A/T)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO45 Gene

Variant ID Type Subtype PubMed ID
dgv5375n71 CNV Gain 21882294
nsv829828 CNV Loss 17160897

Relevant External Links for FBXO45 Gene

HapMap Linkage Disequilibrium report
FBXO45
Human Gene Mutation Database (HGMD)
FBXO45

Disorders for FBXO45 Gene

Relevant External Links for FBXO45

Human Genome Epidemiology (HuGE) Navigator
FBXO45
genes like me logo Genes that share disorders with FBXO45: view

No data available for UniProtKB/Swiss-Prot for FBXO45 Gene

Publications for FBXO45 Gene

  1. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. (PMID: 19581926) Peschiaroli A. … Melino G. (Oncogene 2009) 3 4
  2. Characterization of estrogen-induced F-box protein FBXO45. (PMID: 16012741) Yoshida K. (Oncol. Rep. 2005) 3 23
  3. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4
  4. Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. (PMID: 19398581) Saiga T. … Nakayama K.I. (Mol. Cell. Biol. 2009) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for FBXO45 Gene

Sources for FBXO45 Gene

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